General Terms and Conditions

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Krd/Krd

        involves: C3H/He * C57BL/6 * YBR/Ki

• lethality-prenatal/perinatal
• embryonic lethality at implantation (MGI Ref ID J:20807)
  • no homozygote embryos are present at E10.5 and the lack of resorbed embryos suggests that lethality occurs before implantation

Krd/Krd⁺

        involves: C3H/He * C57BL/6 * YBR/Ki

• lethality-postnatal
• postnatal lethality (MGI Ref ID J:20807)
  • the expected 50% transgenic offspring are observed at weaning when the founder mice are crossed with C57BL/6
  • the percentage of transgenic offspring fall in subsequent backcrosses to C57BL/6 with 35% being transgenic in the 2^nd backcross, 19% being transgenic in the 3^rd backcross, and 11% being transgenic in the 4^th
  • lethality in the backcrosses to C57BL/6 occurs in the late fetal or early postnatal stage with at least some of the mice dying from kidney aplasia
  • percentages of transgenic offspring are closer to expected rates when founder mice are crossed with C3H/HeJ mice with 46% being transgenic in the 2^nd backcross and 42% being transgenic in the 3^rd backcross
• growth/size phenotype
• postnatal slow weight gain (MGI Ref ID J:20807)
  • the growth of these mice is retarded for the first 2 months of birth being about 80% of littermate controls
  • normal weight is eventually reached
• renal/urinary system phenotype
• abnormal nephron morphology (MGI Ref ID J:20807)
  • the number of mature nephrons is smaller
• absent kidney (MGI Ref ID J:20807)
  • kidneys were absent in one stillborn pup that occurred among 24 observed births
• decreased kidney weight (MGI Ref ID J:20807)
  • kidneys with no obvious defects weigh significantly less with a mean of 4.8 mg/g bodyweight compared to 6.2 mg/g for kidneys from littermate controls
• delayed kidney development (MGI Ref ID J:20807)
  • kidneys from these mice demonstrate considerable immaturity compared with wild-type mice
  • the nephrogenic zone is attenuated and disorganized
  • the thickness of the cortical tissue is decreased due in part to less numbers of glomeruli and a smaller profile of proximal convoluted tubules
  • immature mesenchymal tissue is more prominent at the corticomedullary junction
  • these immature features are still present at a lesser degree in mice 4 days old but disappear by adulthood
• kidney cysts (MGI Ref ID J:20807)
  • unilateral kidney cysts are common in these mice
• single kidney (MGI Ref ID J:20807)
  • only one kidney is present in 13% of mice
• ureter dilation (MGI Ref ID J:20807)
  • is commonly observed
• vision/eye phenotype
• abnormal eye electrophysiology (MGI Ref ID J:20807)
  • the electroretinograms of eight mice varied from three in low normal range to three that are extremely abnormal
  • both a- and b- waves are abnormal in mice in affected mice
• abnormal retinal layer morphology (MGI Ref ID J:20807)
  • retinas of some mice are noticeably thinner than controls, with extreme hypocellularity occurring in different positions in the retina
• disorganized retinal layers (MGI Ref ID J:20807)
  • all mice contain malformations of the retina
  • these malformations differed between animals but include zones of narrowing, an excess of somota in a single nuclear layer, photoreceptor nuclei lying ectopically within the photoreceptor layer, and rosettes of photoreceptors enclosed between retinal layers
• thin retinal inner nuclear layer (MGI Ref ID J:20807)
  • the nuclear layers are thinner with fewer somata present than in controls
• thin retinal outer nuclear layer (MGI Ref ID J:20807)
  • the nuclear layers are thinner with fewer somata present than in controls