Strain Name: |
C3.BLiA Pde6b+-Krd/J |
|---|---|
Stock Number: |
002802 |
Availability: | Repository- Live |
General Terms and Conditions |
| Genes & Alleles | Krd; Pde6b; Pde6b+; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type Deletion Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Strain Mating System Hemizygote x Inbred (Female x Male) Species laboratory mouse Generation ?+F18 (28-DEC-04) Appearance
agouti
Related Genotype: A/A Krd/+
agouti, unaffected
Related Genotype: A/A +/+Important Note
This strain carries a chromosome 19 deletion that includes: Abcc2, Fgf8, Nkx2-3, Pax2, Scd1, Tlx1, Wnt8b, and Hps1ep. This congenic is homozygous for the wildtype Pde6b+ allele.Strain Description
This is a semidominant, homozygous lethal mutation.Strain Development
(C57BL/6J x C3H)F1 eggs were microinjected with an amylase/rat elastase/chloramphenicol acetyltransferase construct and the founders were bred to C57BL/6J, then to YBR (Johnson et al., 1993). This strain came to The Jackson Laboratory from Dr. Miriam Meisler at the University of Michigan in 1995 as STOCK Tg8052/C3H at N2 to C3H. At The Jackson Laboratory it was bred to C3HeB/FeJ, then one generation to BALB/cByJ. The Krd/+ F1 offspring were then mated with C3.BliA-Pde6b+ (001912) at each generation to produce the congenic C3.BLiA-Pde6b+ -Krd/+ (002802) that we currently offer. The X and Y chromosomes from C3.BliA-Pde6b+ (001912) were captured and fixed in 002802 within the first 3 backcross generations. Since 1995 the Krd/+ breeders were selected primarily by expression of the retinal degeneration phenotype. This strain has passed through only approximately 2 generations per year.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Krd | ||
|---|---|---|---|
| Allele Name | kidney and retinal defects | ||
| Common Name(s) | Tg8052; | ||
| Molecular Note | The phenotype of this mouse has been attributed to a 7 cM transgene induced deletion, Del(19)TgN8052Mm, which includes the Pax2 and Pkd2l1. The transgene inserted into a LINE element in the distal region of Chromosome 19. The Scd1 and pale ear Hps1 genesare also deleted in Del(19)TgN8052Mm mice, along with several D19Mit markers. [MGI Ref ID J:20807] [MGI Ref ID J:50327] | ||
| Allele Symbol | Pde6b+ | ||
| Allele Name | wild type | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| Allele | Control | |
|---|---|---|
| Krd | Wild-type from the colony | |
| Krd | 001912 C3A.BLiA-Pde6b+/J | |
| Considerations for Choosing Controls | ||
Deletion
005535 B6.129S7-Del(11Cops3-Zfp179)1Jrl/J 003374 B6;129S2-H2dlAb1-Ea/J 005654 B6C3-Del(16Cbr1-ORF9)1Rhr/J 004406 C3HeB/FeJ-Pou3f4del-J/J 002142 STOCK 11R30m/J 004711 STOCK Ednrbs-52Pub View Deletion (6 strains)
Strains carrying Pde6b+ allele
001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (5 strains)
Strains carrying other alleles of Pde6b
View Strains carrying other alleles of Pde6b (77 strains)
Congenic Nomenclature
Room Number A1
Krd related
Pde6b+ relatedInternal/Organ Research
Kidney Defects
Sensorineural Research
Eye Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration (wild-type)
| Strain Name: | C3.BLiA Pde6b+-Krd/J |
| Stock Number: | 002802 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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