Strain Name: |
B6.129-Tnfrsf1atm1Mak/J |
|---|---|
Stock Number: |
002818 |
Availability: | Level 4 |
General Terms and Conditions |
| Former Name |
Tnfr1 (Changed: 15-DEC-04
) |
| Genes & Alleles | Tnfrsf1a; Tnfrsf1atm1Mak; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain C57BL/6 Donor Strain 129S2 via D3 ES cell line Donating Investigator Tak Mak, University Health Network/Un of Toronto Generation N13F?+24 (20-DEC-06) Appearance
black
Related Genotype: a/aStrain Description
Mice homozygous for the Tnfrsf1atm1Mak targeted mutation (formerly Tnfr1tm1Mak) have normal thymocyte development, lymphocyte populations and clonal deletion of potentially self-reactive T cells. TNF signaling is largely abolished, with no TNF induction of NF-kB. Homozygous mutant mice are resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin but succumb to L. monocytogenes infection. TNFRSF1an may also protect against atherosclerotic lesion development in mice fed an atherogenic diet.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tnfrsf1atm1Mak | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Tak Mak | ||
| Common Name(s) | TNF-R1-; TNF-alphaRI-; TNFR-; TNFR1-; TNFR1/p55-; TNFRp55-; Tnfrsf1atm1Mak; Tnfrsf1a-; | ||
| Mutation Made By | Tak Mak, University Health Network/Un of Toronto | ||
| Strain of Origin | 129S2/SvPas | ||
| ES Cell Line Name | D3 | ||
| ES Cell Line Strain | 129S2/SvPas | ||
| Gene Symbol and Name | Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | CD120a; FPF; MGC19588; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR1; TNFR55; TNFR60; TNFRI; TNFRp55; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; | ||
| Molecular Note | A neomycin cassette was inserted at position 535 of the coding sequence. A radioligand binding assay demonstrated that no functional protein was present on the cell surface of splenocytes derived from homozygous mice. [MGI Ref ID J:29283] [MGI Ref ID J:4753] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Tnfrsf1atm1Mak | 000664 C57BL/6J | |
| Considerations for Choosing Controls | ||
Genotyping Protocols
Tnfrsf1atm1Mak
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying other alleles of Tnfrsf1a
003244 B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J 003243 B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J 003242 C57BL/6-Tnfrsf1atm1Imx/J View Strains carrying other alleles of Tnfrsf1a (3 strains)
Additional Web Information
Congenic Nomenclature
Genetic Quality Control Annual Report
Animal Health Reports
Room Number AX8
Research Applications
This mouse can be used to support research in many areas including:Tnfrsf1atm1Mak related
Apoptosis Research
Death Receptors
Cancer Research
Growth Factors/Receptors/Cytokines
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Inflammation
References
Selected Reference(s)
Additional ReferencesPfeffer K; Matsuyama T; Kundig TM; Wakeham A; Kishihara K; Shahinian A; Wiegmann K; Ohashi PS; Kronke M; Mak TW. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73(3):457-67. [PubMed: 8387893] [MGI Ref ID J:4753]
Price and Supply Information
| Strain Name: | B6.129-Tnfrsf1atm1Mak/J |
| Stock Number: | 002818 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
|---|---|
| Supply Notes |
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
For additional Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form