Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names DBA/1LacJ-lahJ/+    (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N2F19p

Appearance
dilute brown, affected
Related Genotype: a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d Dsg4^lah-J/Dsg4^lah-J

dilute brown, unaffected
Related Genotype: a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d Dsg4^lah-J/+ or a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d +/+

Description
Mice homozygous for the Dsg4^lah-J mutation completely lack vibrissae and develop only very short hair that resembles peach fuzz. This is lost by a few months of age, leaving these mice bald. They are runted from birth throughout life. These mice have hyperplasia in the interfollicular epidermis that leads to thickened skin, and their skin wrinkles as they age. Transmission electron micrographs of epidermis from Dsg4^lah-J homozygotes reveals acantholysis with small, poorly formed, and dislodged desmosomes. Rather than the normal gradual transition of keratinocytes from proliferation to differentiation in the lower hair follicle, the lanceolate hair mice show a premature, abrupt switch. Above the melanogenic zone a swelling forms that subsequently is pushed out by continued growth of the hair shaft to become the distal tip of the hair. Lanceolate hair mice take their name from the resulting lance-head shape of the hair. The less severely affected homozygotes can be used for breeding. Mice homozygous for either Dsg4^lah or Dsg4^lah-J have elevated serum IgE. (Montagutelli et al., 1996; Sundberg et al., 2000; Kljuic et al., 2003.)

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Dsg4

002839

CByJ.LAH-Dsg4lah/J

View Strains carrying other alleles of Dsg4     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Dsg4^lah-J/Dsg4^lah-J

        DBA/1LacJ

• skin/coat/nails phenotype
• abnormal hair growth (MGI Ref ID J:83117)
• abnormal hair texture (MGI Ref ID J:83117)
• abnormal skin condition/ morphology (MGI Ref ID J:83117)
• touch/vibrissae phenotype
• abnormal vibrissa morphology (MGI Ref ID J:83117)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Dsg4^lah-J related

Cell Biology Research
Cell Cycle Regulation
Defects in Cell Adhesion Molecules
Genes Regulating Growth and Proliferation
Signal Transduction

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Defects in Cell Adhesion Molecules
Growth Defects
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Dsg4lah-J
Allele Name		lanceolate hair Jackson
Allele Type		Spontaneous
Strain of Origin		DBA/1LacJ
Gene Symbol and Name		Dsg4, desmoglein 4
Chromosome		18
Gene Common Name(s)		CDGF13; CDHF13; LAH; lah; lanceolate hair;
Molecular Note		A spontaneous mutant found to be allelic to lah by complementation testing. The mutation in lahJ allele was identified as a single base insertion within exon 7 at following nucleotide 746. The frameshift creates a premature termination codon resulting in an unstable mRNA product. [MGI Ref ID J:83118]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Kljuic A; Bazzi H; Sundberg JP; Martinez-Mir A; O'Shaughnessy R; Mahoney MG; Levy M; Montagutelli X; Ahmad W; Aita VM; Gordon D; Uitto J; Whiting D; Ott J; Fischer S; Gilliam TC; Jahoda CA; Morris RJ; Panteleyev AA; Nguyen VT; Christiano AM. 2003. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113(2):249-60. [PubMed: 12705872]  [MGI Ref ID J:83118]

Sundberg JP; Boggess D; Bascom C; Limberg BJ; Shultz LD; Sundberg BA; King LE Jr; Montagutelli X. 2000. Lanceolate hair-J (lahJ): a mouse model for human hair disorders. Exp Dermatol 9(3):206-18. [PubMed: 10839719]  [MGI Ref ID J:83117]

Dsg4^lah-J related

Bazzi H; Martinez-Mir A; Kljuic A; Christiano AM. 2005. Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats. J Investig Dermatol Symp Proc 10(3):222-4. [PubMed: 16382669]  [MGI Ref ID J:104686]

Kljuic A; Bazzi H; Sundberg JP; Martinez-Mir A; O'Shaughnessy R; Mahoney MG; Levy M; Montagutelli X; Ahmad W; Aita VM; Gordon D; Uitto J; Whiting D; Ott J; Fischer S; Gilliam TC; Jahoda CA; Morris RJ; Panteleyev AA; Nguyen VT; Christiano AM. 2003. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113(2):249-60. [PubMed: 12705872]  [MGI Ref ID J:83118]

Sundberg JP; Boggess D; Bascom C; Limberg BJ; Shultz LD; Sundberg BA; King LE Jr; Montagutelli X. 2000. Lanceolate hair-J (lahJ): a mouse model for human hair disorders. Exp Dermatol 9(3):206-18. [PubMed: 10839719]  [MGI Ref ID J:83117]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page. Cryorecovery - Standard. At least two mice that carry the mutation (if it is a mutant strain) will be provided. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotypes and genders are needed. IMPORTANT NOTE: The genotypes of the animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire for possible genotypes for this specific strain. Animals typically ship within 13 to 16 weeks from your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will typically ship within 25 weeks. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

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