Strain Name:

B6;129P2-Fcer1gtm1Rav/J

Stock Number:

002847

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Jeffrey V. Ravetch,   Memorial Sloan Kettering Cancer Center

Appearance
pink-eyed grey
Related Genotype: Oca2p/Oca2p

black
Related Genotype: a/a

Description
Mice homozygous for the Fcer1gtm1Rav targeted mutation are viable and fertile. Immune system defects include: inability to phagocytose Ab-coated particles despite normal binding, defective NK cell-mediated Ab-dependent cytotoxicity and mast cell-mediated allergic responses. T cell development is normal. Inflammatory response to immune complexes is attentuated (lack of Arthus response). Homozygotes are completely resistant to experimental immune thrombocytopenia induced by mouse anti-platelet antibodies.

Development
A targeting vector containing a NEO cassette was used to disrupt exon 2, which created a new stop codon 239 bp downstream of the integration site. The construct was electroporated into 129P2/OlaHsd derived E14 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and maintained on the mixed B6;129P2 background.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fcer1gtm1Rav allele
017793   D1.129P2(B6)-Fcer1gtm1Rav/J
View Strains carrying   Fcer1gtm1Rav     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Fcer1gtm1Rav/Fcer1gtm1Rav

        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • the development of NK T cells is normal in these mice   (MGI Ref ID J:28282)
    • abnormal immune cell physiology   (MGI Ref ID J:39248)
      • abnormal NK cell physiology
        • antibody dependent, cell-mediated cytotoxicity almost totally lost   (MGI Ref ID J:39248)
      • abnormal dendritic cell antigen presentation
        • deficient antigen presentation by bone marrow dendritic cells   (MGI Ref ID J:83995)
      • abnormal immunoglobulin level
        • serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)   (MGI Ref ID J:78659)
        • increased IgE level
          • serum IgE response to OVA challenge of sensitized mice greater than that of controls   (MGI Ref ID J:78659)
      • abnormal mast cell physiology
        • loss of IgE and IgG2a binding   (MGI Ref ID J:39248)
        • IgG1 binding normal   (MGI Ref ID J:39248)
        • degranulation and serotonin release largely suppressed   (MGI Ref ID J:39248)
        • significantly reduced prostaglandin D2 release   (MGI Ref ID J:39248)
      • impaired macrophage phagocytosis
        • phagocytosis blocked regardless of Ig binding   (MGI Ref ID J:39248)
    • decreased susceptibility to experimental autoimmune encephalomyelitis
      • considerably reduced when induced with myelin oligodendrocyte glycoprotein   (MGI Ref ID J:126520)
      • more frequent disease remission   (MGI Ref ID J:126520)
      • completely protected against anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein   (MGI Ref ID J:126520)
      • fewer inflammatory foci in the central nervous system   (MGI Ref ID J:126520)
    • decreased susceptibility to type I hypersensitivity reaction
      • unable to mount a passive cutaneous anaphylactic response   (MGI Ref ID J:39248)
      • IgG1 dependent passive systemic anaphylaxis does not occur   (MGI Ref ID J:78659)
      • sensitized mice survive OVA challenge whereas controls die within 20 minutes   (MGI Ref ID J:78659)
  • cardiovascular system phenotype
  • decreased myocardial infarction size
    • infarct size after coronary occlusion/reperfusion is significantly reduced   (MGI Ref ID J:112819)
    • fewer platelet microthrombi and neutrophils in the capillaries of the myocardium   (MGI Ref ID J:112819)
    • occluded microthrombi in 12% of capillaries as compared to 38% in controls   (MGI Ref ID J:112819)
  • homeostasis/metabolism phenotype
  • abnormal platelet activation
    • while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets   (MGI Ref ID J:118488)
    • platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets   (MGI Ref ID J:118488)
    • platelet calcium response fluctuates and is lower than in wild-type platelets   (MGI Ref ID J:118488)
    • decreased platelet aggregation
      • reduced aggregation in response to collagen   (MGI Ref ID J:112819)
  • decreased myocardial infarction size
    • infarct size after coronary occlusion/reperfusion is significantly reduced   (MGI Ref ID J:112819)
    • fewer platelet microthrombi and neutrophils in the capillaries of the myocardium   (MGI Ref ID J:112819)
    • occluded microthrombi in 12% of capillaries as compared to 38% in controls   (MGI Ref ID J:112819)
  • decreased platelet calcium level   (MGI Ref ID J:118488)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • antibody dependent, cell-mediated cytotoxicity almost totally lost   (MGI Ref ID J:39248)
  • abnormal immunoglobulin level
    • serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)   (MGI Ref ID J:78659)
    • increased IgE level
      • serum IgE response to OVA challenge of sensitized mice greater than that of controls   (MGI Ref ID J:78659)
  • abnormal mast cell physiology
    • loss of IgE and IgG2a binding   (MGI Ref ID J:39248)
    • IgG1 binding normal   (MGI Ref ID J:39248)
    • degranulation and serotonin release largely suppressed   (MGI Ref ID J:39248)
    • significantly reduced prostaglandin D2 release   (MGI Ref ID J:39248)
  • abnormal platelet activation
    • while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets   (MGI Ref ID J:118488)
    • platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets   (MGI Ref ID J:118488)
    • platelet calcium response fluctuates and is lower than in wild-type platelets   (MGI Ref ID J:118488)
    • decreased platelet aggregation
      • reduced aggregation in response to collagen   (MGI Ref ID J:112819)
  • decreased platelet calcium level   (MGI Ref ID J:118488)
  • impaired macrophage phagocytosis
    • phagocytosis blocked regardless of Ig binding   (MGI Ref ID J:39248)
  • skeleton phenotype
  • *normal* skeleton phenotype
    • mice exhibit normal bone volume and osteoclast function   (MGI Ref ID J:89583)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fcer1gtm1Rav/Fcer1gtm1Rav

        B6.129P2-Fcer1gtm1Rav
  • immune system phenotype
  • decreased interleukin-1 beta secretion
    • by BMDCs in response to water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-10 secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-12b secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-23 secretion
    • by BMDCs stimulated by yeast form of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-6 secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased tumor necrosis factor secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)

Fcer1gtm1Rav/Fcer1gtm1Rav

        involves: 129P2/OlaHsd
  • immune system phenotype
  • increased susceptibility to parasitic infection
    • after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice   (MGI Ref ID J:163761)
    • however, transfer of bone marrow from KitW-sh homozygotes restores repletion   (MGI Ref ID J:163761)
  • hematopoietic system phenotype
  • abnormal hemoglobin
    • increased hemisphere hemoglobin content in mouse brains injected with phosphate buffered saline   (MGI Ref ID J:168556)
  • decreased platelet aggregation
    • mutants exhibit a lack of collagen-induced aggregation of platelets   (MGI Ref ID J:165893)
  • cardiovascular system phenotype
  • hematoma
    • greatly enlarged area of experimentally induced hematomas   (MGI Ref ID J:168556)
  • homeostasis/metabolism phenotype
  • decreased platelet aggregation
    • mutants exhibit a lack of collagen-induced aggregation of platelets   (MGI Ref ID J:165893)
  • skeleton phenotype
  • *normal* skeleton phenotype
    • no effect on osteoclast size and number in tibias   (MGI Ref ID J:197378)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fcer1gtm1Rav related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fcer1gtm1Rav
Allele Name targeted mutation 1, Jeffrey V Ravetch
Allele Type Targeted (knock-out)
Common Name(s) FcR gamma-; FcR-; FcRKO; FcRg-; FcRgamma-; FcRgamma-chain-; FcRgammanl; FcRgammac-; Fcepsilonrgamma-; Fcer1gtm1; Fcer1gtm1Ra; Fcerg1tm1; FcgammaR-; gamma-;
Mutation Made ByDr. Jeffrey Ravetch,   Memorial Sloan Kettering Cancer Center
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide
Chromosome 1
Gene Common Name(s) AI573376; FCRG; Fc epsilon high affinity receptor gamma; FcR-gamma; FcR[g]; FcRgamma; Fce1g; FcepsilonRI; Ly-50; expressed sequence AI573376; lymphocyte antigen 50;
Molecular Note A neomycin selection cassette was inserted into exon 2, creating a new stop codon 239 bp downstream of the integration site. RT-PCR analysis on RNA isolated from activated macrophages, mast cells and NK cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from activated macrophages, mast cells and NK cells of homozygous mice confirmed that no protein is encoded by this allele. [MGI Ref ID J:39248]

Genotyping

Genotyping Information

Genotyping Protocols

Fcer1gtm1Ravalternate1, Separated PCR
Fcer1gtm1Rav, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Takai T; Li M; Sylvestre D; Clynes R; Ravetch JV. 1994. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76(3):519-29. [PubMed: 8313472]  [MGI Ref ID J:39248]

Additional References

Clynes R; Ravetch JV. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3(1):21-6. [PubMed: 7621075]  [MGI Ref ID J:78887]

Das P; Howard V; Loosbrock N; Dickson D; Murphy MP; Golde TE. 2003. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J Neurosci 23(24):8532-8. [PubMed: 13679422]  [MGI Ref ID J:85527]

Ji H; Ohmura K; Mahmood U; Lee DM; Hofhuis FM; Boackle SA; Takahashi K; Holers VM; Walport M; Gerard C; Ezekowitz A; Carroll MC; Brenner M; Weissleder R; Verbeek JS; Duchatelle V; Degott C; Benoist C; Mathis D. 2002. Arthritis critically dependent on innate immune system players. Immunity 16(2):157-68. [PubMed: 11869678]  [MGI Ref ID J:74720]

Wipke BT; Wang Z; Nagengast W; Reichert DE; Allen PM. 2004. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol 172(12):7694-702. [PubMed: 15187152]  [MGI Ref ID J:90825]

Fcer1gtm1Rav related

Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. [PubMed: 19414806]  [MGI Ref ID J:148317]

Albanesi M; Mancardi DA; Macdonald LE; Iannascoli B; Zitvogel L; Murphy AJ; Leusen JH; Bruhns P. 2012. Cutting Edge: FcgammaRIII (CD16) and FcgammaRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma. J Immunol 189(12):5513-7. [PubMed: 23150715]  [MGI Ref ID J:190859]

Aloulou M; Ben Mkaddem S; Biarnes-Pelicot M; Boussetta T; Souchet H; Rossato E; Benhamou M; Crestani B; Zhu Z; Blank U; Launay P; Monteiro RC. 2012. IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses. Blood 119(13):3084-96. [PubMed: 22337713]  [MGI Ref ID J:182509]

Andreu P; Johansson M; Affara NI; Pucci F; Tan T; Junankar S; Korets L; Lam J; Tawfik D; Denardo DG; Naldini L; de Visser KE; De Palma M; Coussens LM. 2010. FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis. Cancer Cell 17(2):121-134. [PubMed: 20138013]  [MGI Ref ID J:157152]

Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest 119(10):2990-9. [PubMed: 19770513]  [MGI Ref ID J:154634]

Arase H; Ono S; Arase N; Park SY; Wakizaka K; Watanabe H; Ohno H; Saito T. 1995. Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. J Exp Med 182(3):891-5. [PubMed: 7650493]  [MGI Ref ID J:28282]

Aubin E; Lemieux R; Bazin R. 2010. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 115(9):1727-34. [PubMed: 19965673]  [MGI Ref ID J:157778]

Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. [PubMed: 21824820]  [MGI Ref ID J:178253]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barnes N; Gavin AL; Tan PS; Mottram P; Koentgen F; Hogarth PM. 2002. FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Immunity 16(3):379-89. [PubMed: 11911823]  [MGI Ref ID J:86281]

Barrett NA; Maekawa A; Rahman OM; Austen KF; Kanaoka Y. 2009. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 182(2):1119-28. [PubMed: 19124755]  [MGI Ref ID J:143482]

Barrow AD; Raynal N; Andersen TL; Slatter DA; Bihan D; Pugh N; Cella M; Kim T; Rho J; Negishi-Koga T; Delaisse JM; Takayanagi H; Lorenzo J; Colonna M; Farndale RW; Choi Y; Trowsdale J. 2011. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest 121(9):3505-16. [PubMed: 21841309]  [MGI Ref ID J:178250]

Baumann U; Kohl J; Tschernig T; Schwerter-Strumpf K; Verbeek JS; Schmidt RE; Gessner JE. 2000. A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. J Immunol 164(2):1065-70. [PubMed: 10623857]  [MGI Ref ID J:59290]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bergtold A; Gavhane A; D'Agati V; Madaio M; Clynes R. 2006. FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol 177(10):7287-95. [PubMed: 17082647]  [MGI Ref ID J:140615]

Bevaart L; Jansen MJ; van Vugt MJ; Verbeek JS; van de Winkel JG; Leusen JH. 2006. The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma. Cancer Res 66(3):1261-4. [PubMed: 16452176]  [MGI Ref ID J:106686]

Biburger M; Aschermann S; Schwab I; Lux A; Albert H; Danzer H; Woigk M; Dudziak D; Nimmerjahn F. 2011. Monocyte subsets responsible for immunoglobulin g-dependent effector functions in vivo. Immunity 35(6):932-44. [PubMed: 22169040]  [MGI Ref ID J:179288]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Blink SE; Fu YX. 2010. IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation. Cell Immunol 264(1):54-60. [PubMed: 20494341]  [MGI Ref ID J:162109]

Block H; Herter JM; Rossaint J; Stadtmann A; Kliche S; Lowell CA; Zarbock A. 2012. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med 209(2):407-21. [PubMed: 22291096]  [MGI Ref ID J:181695]

Boilard E; Larabee K; Shnayder R; Jacobs K; Farndale RW; Ware J; Lee DM. 2011. Platelets Participate in Synovitis via Cox-1-Dependent Synthesis of Prostacyclin Independently of Microparticle Generation. J Immunol 186(7):4361-6. [PubMed: 21357261]  [MGI Ref ID J:170699]

Boross P; van Lent PL; Martin-Ramirez J; van der Kaa J; Mulder MH; Claassens JW; van den Berg WB; Arandhara VL; Verbeek JS. 2008. Destructive Arthritis in the Absence of Both Fc{gamma}RI and Fc{gamma}RIII. J Immunol 180(7):5083-91. [PubMed: 18354234]  [MGI Ref ID J:133367]

Boule MW; Broughton C; Mackay F; Akira S; Marshak-Rothstein A; Rifkin IR. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199(12):1631-40. [PubMed: 15197227]  [MGI Ref ID J:120392]

Boyle KB; Gyori D; Sindrilaru A; Scharffetter-Kochanek K; Taylor PR; Mocsai A; Stephens LR; Hawkins PT. 2011. Class IA Phosphoinositide 3-Kinase {beta} and {delta} Regulate Neutrophil Oxidase Activation in Response to Aspergillus fumigatus Hyphae. J Immunol 186(5):2978-89. [PubMed: 21257963]  [MGI Ref ID J:169412]

Braun A; Gessner JE; Varga-Szabo D; Syed SN; Konrad S; Stegner D; Vogtle T; Schmidt RE; Nieswandt B. 2009. STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood 113(5):1097-104. [PubMed: 18941110]  [MGI Ref ID J:144644]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cascio JA; Haymaker CL; Divekar RD; Zaghouani S; Khairallah MT; Wan X; Rowland LM; Dhakal M; Chen W; Zaghouani H. 2013. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol 190(12):6004-14. [PubMed: 23686493]  [MGI Ref ID J:204839]

Castano AP; Lin SL; Surowy T; Nowlin BT; Turlapati SA; Patel T; Singh A; Li S; Lupher ML Jr; Duffield JS. 2009. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1(5):5ra13. [PubMed: 20368175]  [MGI Ref ID J:167887]

Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002]  [MGI Ref ID J:191423]

Charles JF; Humphrey MB; Zhao X; Quarles E; Nakamura MC; Aderem A; Seaman WE; Smith KD. 2008. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 76(6):2439-47. [PubMed: 18391000]  [MGI Ref ID J:136148]

Chiesa S; Mingueneau M; Fuseri N; Malissen B; Raulet DH; Malissen M; Vivier E; Tomasello E. 2006. Multiplicity and plasticity of natural killer cell signaling pathways. Blood 107(6):2364-72. [PubMed: 16291591]  [MGI Ref ID J:125723]

Chou RC; Kim ND; Sadik CD; Seung E; Lan Y; Byrne MH; Haribabu B; Iwakura Y; Luster AD. 2010. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity 33(2):266-78. [PubMed: 20727790]  [MGI Ref ID J:163913]

Chu CL; Yu YL; Shen KY; Lowell CA; Lanier LL; Hamerman JA. 2008. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol 38(1):166-73. [PubMed: 18081038]  [MGI Ref ID J:130527]

Chu N; Thomas BN; Patel SR; Buxbaum LU. 2010. IgG1 Is Pathogenic in Leishmania mexicana Infection. J Immunol 185(11):6939-46. [PubMed: 21037092]  [MGI Ref ID J:166141]

Clynes R; Calvani N; Croker BP; Richards HB. 2005. Modulation of the immune response in pristane-induced lupus by expression of activation and inhibitory Fc receptors. Clin Exp Immunol 141(2):230-7. [PubMed: 15996187]  [MGI Ref ID J:100855]

Clynes R; Ravetch JV. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3(1):21-6. [PubMed: 7621075]  [MGI Ref ID J:78887]

Clynes RA; Towers TL; Presta LG; Ravetch JV. 2000. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-6. [PubMed: 10742152]  [MGI Ref ID J:118052]

Colonna L; Catalano G; Chew C; D'Agati V; Thomas JW; Wong FS; Schmitz J; Masuda ES; Reizis B; Tarakhovsky A; Clynes R. 2010. Therapeutic targeting of Syk in autoimmune diabetes. J Immunol 185(3):1532-43. [PubMed: 20601600]  [MGI Ref ID J:162249]

Corbett AJ; Caminschi I; McKenzie BS; Brady JL; Wright MD; Mottram PL; Hogarth PM; Hodder AN; Zhan Y; Tarlinton DM; Shortman K; Lew AM. 2005. Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional 'danger'. Eur J Immunol 35(10):2815-25. [PubMed: 16143986]  [MGI Ref ID J:113495]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Coxon A; Cullere X; Knight S; Sethi S; Wakelin MW; Stavrakis G; Luscinskas FW; Mayadas TN. 2001. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 14(6):693-704. [PubMed: 11420040]  [MGI Ref ID J:78297]

Dahlin JS; Ivarsson MA; Heyman B; Hallgren J. 2011. IgE Immune Complexes Stimulate an Increase in Lung Mast Cell Progenitors in a Mouse Model of Allergic Airway Inflammation. PLoS One 6(5):e20261. [PubMed: 21625525]  [MGI Ref ID J:172579]

Das P; Howard V; Loosbrock N; Dickson D; Murphy MP; Golde TE. 2003. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J Neurosci 23(24):8532-8. [PubMed: 13679422]  [MGI Ref ID J:85527]

Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907]  [MGI Ref ID J:103998]

Denzel A; Maus UA; Rodriguez Gomez M; Moll C; Niedermeier M; Winter C; Maus R; Hollingshead S; Briles DE; Kunz-Schughart LA; Talke Y; Mack M. 2008. Basophils enhance immunological memory responses. Nat Immunol 9(7):733-42. [PubMed: 18516038]  [MGI Ref ID J:137679]

Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. [PubMed: 17475849]  [MGI Ref ID J:146123]

Devi S; Kuligowski MP; Kwan RY; Westein E; Jackson SP; Kitching AR; Hickey MJ. 2010. Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am J Pathol 177(3):1131-42. [PubMed: 20651232]  [MGI Ref ID J:163451]

DiLillo DJ; Tan GS; Palese P; Ravetch JV. 2014. Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo. Nat Med 20(2):143-51. [PubMed: 24412922]  [MGI Ref ID J:206868]

Diaz de Stahl T; Dahlstrom J; Carroll MC; Heyman B. 2003. A role for complement in feedback enhancement of antibody responses by IgG3. J Exp Med 197(9):1183-90. [PubMed: 12732659]  [MGI Ref ID J:83277]

Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 99(5):915-25. [PubMed: 9062349]  [MGI Ref ID J:78651]

Dubois C; Panicot-Dubois L; Gainor JF; Furie BC; Furie B. 2007. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest 117(4):953-60. [PubMed: 17380206]  [MGI Ref ID J:121278]

Dubois C; Panicot-Dubois L; Merrill-Skoloff G; Furie B; Furie BC. 2006. Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo. Blood 107(10):3902-6. [PubMed: 16455953]  [MGI Ref ID J:132728]

Dufour JH; Dziejman M; Liu MT; Leung JH; Lane TE; Luster AD. 2002. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 168(7):3195-204. [PubMed: 11907072]  [MGI Ref ID J:75584]

El Bakkouri K; Descamps F; De Filette M; Smet A; Festjens E; Birkett A; Van Rooijen N; Verbeek S; Fiers W; Saelens X. 2011. Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection. J Immunol 186(2):1022-31. [PubMed: 21169548]  [MGI Ref ID J:168757]

Enomoto Y; Yamanishi Y; Izawa K; Kaitani A; Takahashi M; Maehara A; Oki T; Takamatsu R; Kajikawa M; Takai T; Kitamura T; Kitaura J. 2010. Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem 285(46):35274-83. [PubMed: 20817736]  [MGI Ref ID J:166868]

Erez N; Truitt M; Olson P; Hanahan D. 2010. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell 17(2):135-147. [PubMed: 20138012]  [MGI Ref ID J:157153]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Feng P; Zhao H; Chai J; Huang L; Wang H. 2012. Expression and secretion of TNF-alpha in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS One 7(8):e43140. [PubMed: 22905218]  [MGI Ref ID J:189902]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

Geier H; Celli J. 2011. Phagocytic Receptors Dictate Phagosomal Escape and Intracellular Proliferation of Francisella tularensis. Infect Immun 79(6):2204-14. [PubMed: 21422184]  [MGI Ref ID J:171926]

Getahun A; Dahlstrom J; Wernersson S; Heyman B. 2004. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors. J Immunol 172(9):5269-76. [PubMed: 15100265]  [MGI Ref ID J:89643]

Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644-54. [PubMed: 14660741]  [MGI Ref ID J:86845]

Gjertsson I; Kleinau S; Tarkowski A. 2002. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 33(4):145-52. [PubMed: 12385742]  [MGI Ref ID J:102982]

Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209]  [MGI Ref ID J:92709]

Goerge T; Ho-Tin-Noe B; Carbo C; Benarafa C; Remold-O'Donnell E; Zhao BQ; Cifuni SM; Wagner DD. 2008. Inflammation induces hemorrhage in thrombocytopenia. Blood 111(10):4958-64. [PubMed: 18256319]  [MGI Ref ID J:135316]

Goins CL; Chappell CP; Shashidharamurthy R; Selvaraj P; Jacob J. 2010. Immune complex-mediated enhancement of secondary antibody responses. J Immunol 184(11):6293-8. [PubMed: 20439912]  [MGI Ref ID J:161221]

Graham DB; Akilesh HM; Gmyrek GB; Piccio L; Gilfillan S; Sim J; Belizaire R; Carrero JA; Wang Y; Blaufuss GS; Sandoval G; Fujikawa K; Cross AH; Russell JH; Cella M; Swat W. 2010. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood 116(17):3208-18. [PubMed: 20634378]  [MGI Ref ID J:165865]

Graham DB; Stephenson LM; Lam SK; Brim K; Lee HM; Bautista J; Gilfillan S; Akilesh S; Fujikawa K; Swat W. 2007. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med 204(12):2889-97. [PubMed: 17984307]  [MGI Ref ID J:128521]

Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. [PubMed: 11920579]  [MGI Ref ID J:115364]

Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162]  [MGI Ref ID J:125267]

Guo S; Muhlfeld AS; Wietecha TA; Peutz-Kootstra CJ; Kowalewska J; Yi K; Spencer M; Pichaiwong W; Nimmerjahn F; Hudkins KL; Alpers CE. 2009. Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. Am J Pathol 175(1):107-18. [PubMed: 19528347]  [MGI Ref ID J:150036]

Hall LR; Diaconu E; Pearlman E. 2001. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J Immunol 167(2):919-25. [PubMed: 11441099]  [MGI Ref ID J:120230]

Hamaguchi Y; Xiu Y; Komura K; Nimmerjahn F; Tedder TF. 2006. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203(3):743-53. [PubMed: 16520392]  [MGI Ref ID J:123761]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Hartwig C; Mazzega M; Constabel H; Krishnaswamy JK; Gessner JE; Braun A; Tschernig T; Behrens GM. 2010. Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation. Eur J Immunol 40(5):1284-95. [PubMed: 20148421]  [MGI Ref ID J:160960]

Haudek SB; Trial J; Xia Y; Gupta D; Pilling D; Entman ML. 2008. Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells. Proc Natl Acad Sci U S A 105(29):10179-84. [PubMed: 18632582]  [MGI Ref ID J:138327]

Heller T; Gessner JE; Schmidt RE; Klos A; Bautsch W; Kohl J. 1999. Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis. J Immunol 162(10):5657-61. [PubMed: 10229794]  [MGI Ref ID J:78298]

Herbst T; Esser J; Prati M; Kulagin M; Stettler R; Zaiss MM; Hewitson JP; Merky P; Verbeek JS; Bourquin C; Camberis M; Prout M; Maizels RM; Le Gros G; Harris NL. 2012. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A 109(37):14954-9. [PubMed: 22930820]  [MGI Ref ID J:190029]

Hirano M; Davis RS; Fine WD; Nakamura S; Shimizu K; Yagi H; Kato K; Stephan RP; Cooper MD. 2007. IgEb immune complexes activate macrophages through FcgammaRIV binding. Nat Immunol 8(7):762-71. [PubMed: 17558411]  [MGI Ref ID J:123354]

Ho LH; Uehara T; Chen CC; Kubagawa H; Cooper MD. 1999. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci U S A 96(26):15086-90. [PubMed: 10611342]  [MGI Ref ID J:119839]

Hong Y; Peng Y; Xiao H; Mi M; Munn D; He Y. 2012. Immunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization. J Immunol 188(10):4819-27. [PubMed: 22504640]  [MGI Ref ID J:188675]

Huber VC; Lynch JM; Bucher DJ; Le J; Metzger DW. 2001. Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections. J Immunol 166(12):7381-8. [PubMed: 11390489]  [MGI Ref ID J:132607]

Hughan SC; Hughes CE; McCarty OJ; Schweighoffer E; Soultanova I; Ware J; Tybulewicz VL; Watson SP. 2007. GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb Vasc Biol 27(2):422-9. [PubMed: 17110603]  [MGI Ref ID J:147937]

Imai M; Landen C; Ohta R; Cheung NK; Tomlinson S. 2005. Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer. Cancer Res 65(22):10562-8. [PubMed: 16288049]  [MGI Ref ID J:103401]

Inoue O; Suzuki-Inoue K; McCarty OJ; Moroi M; Ruggeri ZM; Kunicki TJ; Ozaki Y; Watson SP. 2006. Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood 107(4):1405-12. [PubMed: 16219796]  [MGI Ref ID J:129315]

Inoue Y; Kaifu T; Sugahara-Tobinai A; Nakamura A; Miyazaki J; Takai T. 2007. Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. J Immunol 179(2):764-74. [PubMed: 17617565]  [MGI Ref ID J:149345]

Inui M; Kikuchi Y; Aoki N; Endo S; Maeda T; Sugahara-Tobinai A; Fujimura S; Nakamura A; Kumanogoh A; Colonna M; Takai T. 2009. Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12. Proc Natl Acad Sci U S A 106(12):4816-21. [PubMed: 19251634]  [MGI Ref ID J:147155]

Ioan-Facsinay A; de Kimpe SJ; Hellwig SM; van Lent PL; Hofhuis FM; van Ojik HH; Sedlik C; da Silveira SA; Gerber J; de Jong YF; Roozendaal R; Aarden LA; van den Berg WB; Saito T; Mosser D; Amigorena S; Izui S; van Ommen GJ; van Vugt M; van de Winkel JG; Verbeek JS. 2002. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16(3):391-402. [PubMed: 11911824]  [MGI Ref ID J:83995]

Jakus Z; Nemeth T; Verbeek JS; Mocsai A. 2008. Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes. J Immunol 180(1):618-29. [PubMed: 18097064]  [MGI Ref ID J:130906]

Jakus Z; Simon E; Frommhold D; Sperandio M; Mocsai A. 2009. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med 206(3):577-93. [PubMed: 19273622]  [MGI Ref ID J:147080]

Ji H; Ohmura K; Mahmood U; Lee DM; Hofhuis FM; Boackle SA; Takahashi K; Holers VM; Walport M; Gerard C; Ezekowitz A; Carroll MC; Brenner M; Weissleder R; Verbeek JS; Duchatelle V; Degott C; Benoist C; Mathis D. 2002. Arthritis critically dependent on innate immune system players. Immunity 16(2):157-68. [PubMed: 11869678]  [MGI Ref ID J:74720]

Jobe SM; Leo L; Eastvold JS; Dickneite G; Ratliff TL; Lentz SR; Di Paola J. 2005. Role of FcRgamma and factor XIIIA in coated platelet formation. Blood 106(13):4146-51. [PubMed: 16105983]  [MGI Ref ID J:124064]

Joller N; Weber SS; Muller AJ; Sporri R; Selchow P; Sander P; Hilbi H; Oxenius A. 2010. Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. Proc Natl Acad Sci U S A 107(47):20441-6. [PubMed: 21048081]  [MGI Ref ID J:166599]

Jonsson F; Mancardi DA; Zhao W; Kita Y; Iannascoli B; Khun H; van Rooijen N; Shimizu T; Schwartz LB; Daeron M; Bruhns P. 2012. Human FcgammaRIIA induces anaphylactic and allergic reactions. Blood 119(11):2533-44. [PubMed: 22138510]  [MGI Ref ID J:182466]

Jozefowski S; Arredouani M; Sulahian T; Kobzik L. 2005. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol 175(12):8032-41. [PubMed: 16339540]  [MGI Ref ID J:122238]

Kane MM; Mosser DM. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol 166(2):1141-7. [PubMed: 11145695]  [MGI Ref ID J:66849]

Kaplan CD; O'Neill SK; Koreny T; Czipri M; Finnegan A. 2002. Development of inflammation in proteoglycan-induced arthritis is dependent on FcgammaR regulation of the cytokine/chemokine environment. J Immunol 169(10):5851-9. [PubMed: 12421967]  [MGI Ref ID J:80076]

Karsten CM; Pandey MK; Figge J; Kilchenstein R; Taylor PR; Rosas M; McDonald JU; Orr SJ; Berger M; Petzold D; Blanchard V; Winkler A; Hess C; Reid DM; Majoul IV; Strait RT; Harris NL; Kohl G; Wex E; Ludwig R; Zillikens D; Nimmerjahn F; Finkelman FD; Brown GD; Ehlers M; Kohl J. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1. Nat Med 18(9):1401-6. [PubMed: 22922409]  [MGI Ref ID J:192766]

Katayama M; Ohmura K; Yukawa N; Terao C; Hashimoto M; Yoshifuji H; Kawabata D; Fujii T; Iwakura Y; Mimori T. 2013. Neutrophils are essential as a source of IL-17 in the effector phase of arthritis. PLoS One 8(5):e62231. [PubMed: 23671588]  [MGI Ref ID J:200527]

Kato K; Kanaji T; Russell S; Kunicki TJ; Furihata K; Kanaji S; Marchese P; Reininger A; Ruggeri ZM; Ware J. 2003. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 102(5):1701-7. [PubMed: 12738669]  [MGI Ref ID J:85315]

Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood 112(4):1109-19. [PubMed: 18524992]  [MGI Ref ID J:138410]

Kim HY; Kim S; Chung DH. 2006. FcgammaRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation. J Clin Invest 116(9):2484-92. [PubMed: 16917543]  [MGI Ref ID J:114452]

Kim JH; Chung DH. 2011. CD1d-restricted IFN-gamma-secreting NKT cells promote immune complex-induced acute lung injury by regulating macrophage-inflammatory protein-1alpha production and activation of macrophages and dendritic cells. J Immunol 186(3):1432-41. [PubMed: 21191075]  [MGI Ref ID J:168903]

Kim SJ; Caton M; Wang C; Khalil M; Zhou ZJ; Hardin J; Diamond B. 2008. Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts. J Exp Med 205(10):2437-48. [PubMed: 18809711]  [MGI Ref ID J:140103]

Kima PE; Constant SL; Hannum L; Colmenares M; Lee KS; Haberman AM; Shlomchik MJ; McMahon-Pratt D. 2000. Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis. J Exp Med 191(6):1063-8. [PubMed: 10727468]  [MGI Ref ID J:124757]

Kirimanjeswara GS; Agosto LM; Kennett MJ; Bjornstad ON; Harvill ET. 2005. Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis. J Clin Invest 115(12):3594-601. [PubMed: 16294220]  [MGI Ref ID J:104702]

Kirimanjeswara GS; Golden JM; Bakshi CS; Metzger DW. 2007. Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis. J Immunol 179(1):532-9. [PubMed: 17579074]  [MGI Ref ID J:149409]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

Kitamura K; Takeda K; Koya T; Miyahara N; Kodama T; Dakhama A; Takai T; Hirano A; Tanimoto M; Harada M; Gelfand EW. 2007. Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J Immunol 178(1):480-8. [PubMed: 17182587]  [MGI Ref ID J:141923]

Kleinau S; Martinsson P; Heyman B. 2000. Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med 191(9):1611-6. [PubMed: 10790435]  [MGI Ref ID J:61920]

Koga T; Inui M; Inoue K; Kim S; Suematsu A; Kobayashi E; Iwata T; Ohnishi H; Matozaki T; Kodama T; Taniguchi T; Takayanagi H; Takai T. 2004. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428(6984):758-63. [PubMed: 15085135]  [MGI Ref ID J:146714]

Kruijsen D; Bakkers MJ; van Uden NO; Viveen MC; van der Sluis TC; Kimpen JL; Leusen JH; Coenjaerts FE; van Bleek GM. 2010. Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections. J Immunol 185(11):6489-98. [PubMed: 20971927]  [MGI Ref ID J:167565]

Kruijsen D; Einarsdottir HK; Schijf MA; Coenjaerts FE; van der Schoot EC; Vidarsson G; van Bleek GM. 2013. Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice. J Virol 87(13):7550-7. [PubMed: 23637394]  [MGI Ref ID J:198438]

Kuijpers MJ; Schulte V; Bergmeier W; Lindhout T; Brakebusch C; Offermanns S; Fassler R; Heemskerk JW; Nieswandt B. 2003. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J 17(6):685-7. [PubMed: 12586747]  [MGI Ref ID J:118488]

Kumar V; Ali SR; Konrad S; Zwirner J; Verbeek JS; Schmidt RE; Gessner JE. 2006. Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest 116(2):512-20. [PubMed: 16453025]  [MGI Ref ID J:105421]

Leo L; Di Paola J; Judd BA; Koretzky GA; Lentz SR. 2002. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood 100(8):2839-44. [PubMed: 12351393]  [MGI Ref ID J:115518]

Letourneau S; van Leeuwen EM; Krieg C; Martin C; Pantaleo G; Sprent J; Surh CD; Boyman O. 2010. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A 107(5):2171-6. [PubMed: 20133862]  [MGI Ref ID J:157531]

Li F; Ravetch JV. 2012. Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement. Proc Natl Acad Sci U S A 109(27):10966-71. [PubMed: 22723355]  [MGI Ref ID J:186418]

Li F; Ravetch JV. 2011. Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333(6045):1030-4. [PubMed: 21852502]  [MGI Ref ID J:174675]

Liang B; Workman C; Lee J; Chew C; Dale BM; Colonna L; Flores M; Li N; Schweighoffer E; Greenberg S; Tybulewicz V; Vignali D; Clynes R. 2008. Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II. J Immunol 180(9):5916-26. [PubMed: 18424711]  [MGI Ref ID J:134316]

Lira A; Kulczycki J; Slack R; Anisman H; Park DS. 2011. Involvement of the Fc{gamma} Receptor in a Chronic N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Dopaminergic Loss. J Biol Chem 286(33):28783-93. [PubMed: 21693708]  [MGI Ref ID J:175922]

Liu J; Gao BB; Clermont AC; Blair P; Chilcote TJ; Sinha S; Flaumenhaft R; Feener EP. 2011. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med 17(2):206-10. [PubMed: 21258336]  [MGI Ref ID J:168556]

Liu J; Pestina TI; Berndt MC; Jackson CW; Gartner TK. 2005. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood 106(8):2750-6. [PubMed: 15985541]  [MGI Ref ID J:119538]

Liu J; Ware J; Jackson CW; Gartner TK. 2007. FcRgamma-chain signals in the absence of glycoprotein VI. J Thromb Haemost 5(1):201-3. [PubMed: 17010148]  [MGI Ref ID J:149580]

Looney MR; Su X; Van Ziffle JA; Lowell CA; Matthay MA. 2006. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest 116(6):1615-23. [PubMed: 16710475]  [MGI Ref ID J:110368]

Lowe DB; Shearer MH; Jumper CA; Bright RK; Kennedy RC. 2007. Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases. J Virol 81(3):1313-8. [PubMed: 17108042]  [MGI Ref ID J:117823]

Lund FE; Schuer K; Hollifield M; Randall TD; Garvy BA. 2003. Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody. J Immunol 171(3):1423-30. [PubMed: 12874234]  [MGI Ref ID J:120666]

Ma G; Pan PY; Eisenstein S; Divino CM; Lowell CA; Takai T; Chen SH. 2011. Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells. Immunity 34(3):385-95. [PubMed: 21376641]  [MGI Ref ID J:170325]

Maeda K; Mehta H; Drevets DA; Coggeshall KM. 2010. IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 115(23):4699-706. [PubMed: 20351305]  [MGI Ref ID J:161550]

Maglione PJ; Xu J; Casadevall A; Chan J. 2008. Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J Immunol 180(5):3329-38. [PubMed: 18292558]  [MGI Ref ID J:131525]

Mancardi DA; Iannascoli B; Hoos S; England P; Daeron M; Bruhns P. 2008. FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest 118(11):3738-50. [PubMed: 18949059]  [MGI Ref ID J:144620]

Mancardi DA; Jonsson F; Iannascoli B; Khun H; Van Rooijen N; Huerre M; Daeron M; Bruhns P. 2011. The murine high-affinity IgG receptor Fc(gamma)RIV is sufficient for autoantibody-induced arthritis. J Immunol 186(4):1899-903. [PubMed: 21248252]  [MGI Ref ID J:169145]

Mangin P; Nonne C; Eckly A; Ohlmann P; Freund M; Nieswandt B; Cazenave JP; Gachet C; Lanza F. 2003. A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1. FEBS Lett 542(1-3):53-9. [PubMed: 12729897]  [MGI Ref ID J:118572]

Mao D; Epple H; Uthgenannt B; Novack DV; Faccio R. 2006. PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest 116(11):2869-79. [PubMed: 17053833]  [MGI Ref ID J:114607]

Martin CE; van Leeuwen EM; Im SJ; Roopenian DC; Sung YC; Surh CD. 2013. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood 121(22):4484-92. [PubMed: 23610371]  [MGI Ref ID J:198495]

Martinsson K; Hultman P. 2006. The role of Fc-receptors in murine mercury-induced systemic autoimmunity. Clin Exp Immunol 144(2):309-18. [PubMed: 16634805]  [MGI Ref ID J:108127]

Masuda A; Yoshida M; Shiomi H; Ikezawa S; Takagawa T; Tanaka H; Chinzei R; Ishida T; Morita Y; Kutsumi H; Inokuchi H; Wang S; Kobayashi K; Mizuno S; Nakamura A; Takai T; Blumberg RS; Azuma T. 2008. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun 76(4):1728-37. [PubMed: 18227164]  [MGI Ref ID J:133533]

McCall-Culbreath KD; Li Z; Zutter MM. 2008. Crosstalk between the alpha2beta1 integrin and c-met/HGF-R regulates innate immunity. Blood 111(7):3562-70. [PubMed: 18198349]  [MGI Ref ID J:133608]

McKenzie SE; Taylor SM; Malladi P; Yuhan H; Cassel DL; Chien P; Schwartz E; Schreiber AD; Surrey S; Reilly MP. 1999. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol 162(7):4311-8. [PubMed: 10201963]  [MGI Ref ID J:93244]

Miyajima I; Dombrowicz D; Martin TR; Ravetch JV; Kinet JP; Galli SJ. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 99(5):901-14. [PubMed: 9062348]  [MGI Ref ID J:78659]

Mocsai A; Abram CL; Jakus Z; Hu Y; Lanier LL; Lowell CA. 2006. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7(12):1326-33. [PubMed: 17086186]  [MGI Ref ID J:116120]

Mocsai A; Humphrey MB; Van Ziffle JA; Hu Y; Burghardt A; Spusta SC; Majumdar S; Lanier LL; Lowell CA; Nakamura MC. 2004. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A 101(16):6158-63. [PubMed: 15073337]  [MGI Ref ID J:89583]

Mohamed HA; Mosier DR; Zou LL; Siklos L; Alexianu ME; Engelhardt JI; Beers DR; Le WD; Appel SH. 2002. Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons. J Neurosci Res 69(1):110-6. [PubMed: 12111822]  [MGI Ref ID J:105030]

Mold C; Rodic-Polic B; Du Clos TW. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 168(12):6375-81. [PubMed: 12055255]  [MGI Ref ID J:123793]

Mold C; Rodriguez W; Rodic-Polic B; Du Clos TW. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol 169(12):7019-25. [PubMed: 12471137]  [MGI Ref ID J:118418]

Mukai K; Matsuoka K; Taya C; Suzuki H; Yokozeki H; Nishioka K; Hirokawa K; Etori M; Yamashita M; Kubota T; Minegishi Y; Yonekawa H; Karasuyama H. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23(2):191-202. [PubMed: 16111637]  [MGI Ref ID J:100537]

Murphy KA; Erickson JR; Johnson CS; Seiler CE; Bedi J; Hu P; Pluhar GE; Epstein AL; Ohlfest JR. 2014. CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol 192(1):224-33. [PubMed: 24293627]  [MGI Ref ID J:207088]

Nakae S; Suto H; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2005. Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A 102(18):6467-72. [PubMed: 15840716]  [MGI Ref ID J:98468]

Nakahashi C; Tahara-Hanaoka S; Totsuka N; Okoshi Y; Takai T; Ohkohchi N; Honda S; Shibuya K; Shibuya A. 2007. Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol 178(2):765-70. [PubMed: 17202337]  [MGI Ref ID J:142632]

Nakamura A; Kobayashi E; Takai T. 2004. Exacerbated graft-versus-host disease in Pirb-/- mice. Nat Immunol 5(6):623-9. [PubMed: 15146181]  [MGI Ref ID J:90629]

Nakamura A; Nukiwa T; Takai T. 2003. Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun 20(3):227-36. [PubMed: 12753808]  [MGI Ref ID J:119452]

Nakamura K; Malykhin A; Coggeshall KM. 2002. The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood 100(9):3374-82. [PubMed: 12384440]  [MGI Ref ID J:115560]

Ng HP; Burris RL; Nagarajan S. 2011. Attenuated atherosclerotic lesions in apoE-Fcgamma-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells. J Immunol 187(11):6082-93. [PubMed: 22043015]  [MGI Ref ID J:179719]

Nieswandt B; Bergmeier W; Schulte V; Rackebrandt K; Gessner JE; Zirngibl H. 2000. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem 275(31):23998-4002. [PubMed: 10825177]  [MGI Ref ID J:115335]

Nieswandt B; Brakebusch C; Bergmeier W; Schulte V; Bouvard D; Mokhtari-Nejad R; Lindhout T; Heemskerk JW; Zirngibl H; Fassler R. 2001. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J 20(9):2120-30. [PubMed: 11331578]  [MGI Ref ID J:78984]

Nigrovic PA; Binstadt BA; Monach PA; Johnsen A; Gurish M; Iwakura Y; Benoist C; Mathis D; Lee DM. 2007. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104(7):2325-30. [PubMed: 17277081]  [MGI Ref ID J:119744]

Nimmerjahn F; Anthony RM; Ravetch JV. 2007. Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. Proc Natl Acad Sci U S A 104(20):8433-7. [PubMed: 17485663]  [MGI Ref ID J:121840]

Nimmerjahn F; Bruhns P; Horiuchi K; Ravetch JV. 2005. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23(1):41-51. [PubMed: 16039578]  [MGI Ref ID J:100540]

Ochi S; Shinohara M; Sato K; Gober HJ; Koga T; Kodama T; Takai T; Miyasaka N; Takayanagi H. 2007. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc Natl Acad Sci U S A 104(27):11394-11399. [PubMed: 17592115]  [MGI Ref ID J:122820]

Oldenborg PA; Gresham HD; Lindberg FP. 2001. CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J Exp Med 193(7):855-62. [PubMed: 11283158]  [MGI Ref ID J:120547]

Onah DN; Uchiyama F; Nagakui Y; Ono M; Takai T; Nawa Y. 2000. Mucosal defense against gastrointestinal nematodes: responses of mucosal mast cells and mouse mast cell protease 1 during primary strongyloides venezuelensis infection in FcRgamma-knockout mice. Infect Immun 68(9):4968-71. [PubMed: 10948112]  [MGI Ref ID J:64075]

Otero K; Turnbull IR; Poliani PL; Vermi W; Cerutti E; Aoshi T; Tassi I; Takai T; Stanley SL; Miller M; Shaw AS; Colonna M. 2009. Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol 10(7):734-43. [PubMed: 19503107]  [MGI Ref ID J:150133]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Padigel UM; Farrell JP. 2005. Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol 174(10):6340-5. [PubMed: 15879134]  [MGI Ref ID J:99049]

Park-Min KH; Serbina NV; Yang W; Ma X; Krystal G; Neel BG; Nutt SL; Hu X; Ivashkiv LB. 2007. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity 26(1):67-78. [PubMed: 17239631]  [MGI Ref ID J:118322]

Pedotti R; DeVoss JJ; Youssef S; Mitchell D; Wedemeyer J; Madanat R; Garren H; Fontoura P; Tsai M; Galli SJ; Sobel RA; Steinman L. 2003. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Proc Natl Acad Sci U S A 100(4):1867-72. [PubMed: 12576552]  [MGI Ref ID J:126520]

Pinheiro da Silva F; Aloulou M; Skurnik D; Benhamou M; Andremont A; Velasco IT; Chiamolera M; Verbeek JS; Launay P; Monteiro RC. 2007. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med 13(11):1368-74. [PubMed: 17934470]  [MGI Ref ID J:130075]

Pozniak CD; Sengupta Ghosh A; Gogineni A; Hanson JE; Lee SH; Larson JL; Solanoy H; Bustos D; Li H; Ngu H; Jubb AM; Ayalon G; Wu J; Scearce-Levie K; Zhou Q; Weimer RM; Kirkpatrick DS; Lewcock JW. 2013. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med 210(12):2553-67. [PubMed: 24166713]  [MGI Ref ID J:207720]

Qin D; Wu J; Vora KA; Ravetch JV; Szakal AK; Manser T; Tew JG. 2000. Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response. J Immunol 164(12):6268-75. [PubMed: 10843680]  [MGI Ref ID J:112126]

Rao SP; Vora KA; Manser T. 2002. Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. J Immunol 169(4):1859-68. [PubMed: 12165510]  [MGI Ref ID J:112043]

Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. Am J Physiol Regul Integr Comp Physiol 280(4):R1037-44. [PubMed: 11247825]  [MGI Ref ID J:114295]

Renne T; Pozgajova M; Gruner S; Schuh K; Pauer HU; Burfeind P; Gailani D; Nieswandt B. 2005. Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 202(2):271-81. [PubMed: 16009717]  [MGI Ref ID J:100529]

Richter K; Oxenius A. 2013. Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcgammaR or complement. Eur J Immunol 43(9):2349-60. [PubMed: 23749374]  [MGI Ref ID J:201331]

Ritter M; Gross O; Kays S; Ruland J; Nimmerjahn F; Saijo S; Tschopp J; Layland LE; Prazeres da Costa C. 2010. Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci U S A 107(47):20459-64. [PubMed: 21059925]  [MGI Ref ID J:166590]

Rosenzweig HL; Martin TM; Planck SR; Galster K; Jann MM; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol 84(2):529-36. [PubMed: 18495787]  [MGI Ref ID J:138433]

Rosetti F; Tsuboi N; Chen K; Nishi H; Ernandez T; Sethi S; Croce K; Stavrakis G; Alcocer-Varela J; Gomez-Martin D; van Rooijen N; Kyttaris VC; Lichtman AH; Tsokos GC; Mayadas TN. 2012. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol 189(7):3714-23. [PubMed: 22933624]  [MGI Ref ID J:190352]

Rotman HL; Daly TM; Clynes R; Long CA. 1998. Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model. J Immunol 161(4):1908-12. [PubMed: 9712060]  [MGI Ref ID J:49081]

Saeki K; Satoh T; Yokozeki H. 2013. alpha(1,3) Fucosyltransferases IV and VII Are Essential for the Initial Recruitment of Basophils in Chronic Allergic Inflammation. J Invest Dermatol 133(9):2161-9. [PubMed: 23657464]  [MGI Ref ID J:200021]

Saijo S; Ikeda S; Yamabe K; Kakuta S; Ishigame H; Akitsu A; Fujikado N; Kusaka T; Kubo S; Chung SH; Komatsu R; Miura N; Adachi Y; Ohno N; Shibuya K; Yamamoto N; Kawakami K; Yamasaki S; Saito T; Akira S; Iwakura Y. 2010. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32(5):681-91. [PubMed: 20493731]  [MGI Ref ID J:160680]

Sato K; Suematsu A; Nakashima T; Takemoto-Kimura S; Aoki K; Morishita Y; Asahara H; Ohya K; Yamaguchi A; Takai T; Kodama T; Chatila TA; Bito H; Takayanagi H. 2006. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12(12):1410-6. [PubMed: 17128269]  [MGI Ref ID J:129599]

Saylor CA; Dadachova E; Casadevall A. 2010. Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors. J Immunol 184(1):336-43. [PubMed: 19949107]  [MGI Ref ID J:159001]

Schoenen H; Bodendorfer B; Hitchens K; Manzanero S; Werninghaus K; Nimmerjahn F; Agger EM; Stenger S; Andersen P; Ruland J; Brown GD; Wells C; Lang R. 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184(6):2756-60. [PubMed: 20164423]  [MGI Ref ID J:160111]

Schubert D; Maier B; Morawietz L; Krenn V; Kamradt T. 2004. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 172(7):4503-9. [PubMed: 15034067]  [MGI Ref ID J:88723]

Seeling M; Hillenhoff U; David JP; Schett G; Tuckermann J; Lux A; Nimmerjahn F. 2013. Inflammatory monocytes and Fcgamma receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice. Proc Natl Acad Sci U S A 110(26):10729-10734. [PubMed: 23754379]  [MGI Ref ID J:197378]

Shao B; Yago T; Coghill PA; Klopocki AG; Mehta-D'souza P; Schmidtke DW; Rodgers W; McEver RP. 2012. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin alphaLbeta2. J Biol Chem 287(23):19585-98. [PubMed: 22511754]  [MGI Ref ID J:186204]

Shinohara M; Koga T; Okamoto K; Sakaguchi S; Arai K; Yasuda H; Takai T; Kodama T; Morio T; Geha RS; Kitamura D; Kurosaki T; Ellmeier W; Takayanagi H. 2008. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132(5):794-806. [PubMed: 18329366]  [MGI Ref ID J:135537]

Shores EW; Ono M; Kawabe T; Sommers CL; Tran T; Lui K; Udey MC; Ravetch J; Love PE. 1998. T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma). J Exp Med 187(7):1093-101. [PubMed: 9529325]  [MGI Ref ID J:46914]

Smith CL; Arvedson TL; Cooke KS; Dickmann LJ; Forte C; Li H; Merriam KL; Perry VK; Tran L; Rottman JB; Maxwell JR. 2013. IL-22 regulates iron availability in vivo through the induction of hepcidin. J Immunol 191(4):1845-55. [PubMed: 23836059]  [MGI Ref ID J:205704]

Smith P; Dilillo DJ; Bournazos S; Li F; Ravetch JV. 2012. Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci U S A 109(16):6181-6. [PubMed: 22474370]  [MGI Ref ID J:183615]

Sotnikov I; Veremeyko T; Starossom SC; Barteneva N; Weiner HL; Ponomarev ED. 2013. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One 8(3):e58979. [PubMed: 23555611]  [MGI Ref ID J:199888]

Stein MP; Mold C; Du Clos TW. 2000. C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol 164(3):1514-20. [PubMed: 10640769]  [MGI Ref ID J:77127]

Stowell SR; Liepkalns JS; Hendrickson JE; Girard-Pierce KR; Smith NH; Arthur CM; Zimring JC. 2013. Antigen modulation confers protection to red blood cells from antibody through Fcgamma receptor ligation. J Immunol 191(10):5013-25. [PubMed: 24108700]  [MGI Ref ID J:206332]

Strait RT; Hicks W; Barasa N; Mahler A; Khodoun M; Kohl J; Stringer K; Witte D; Van Rooijen N; Susskind BM; Finkelman FD. 2011. MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice. J Exp Med 208(12):2525-44. [PubMed: 22025304]  [MGI Ref ID J:178758]

Straub T; Schweier O; Bruns M; Nimmerjahn F; Waisman A; Pircher H. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgammaR. Eur J Immunol 43(9):2338-48. [PubMed: 23749409]  [MGI Ref ID J:201330]

Suffia I; Reckling SK; Salay G; Belkaid Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol 174(9):5444-55. [PubMed: 15845457]  [MGI Ref ID J:98414]

Sumiyoshi K; Mokuno H; Iesaki T; Shimada K; Miyazaki T; Kume A; Kiyanagi T; Kuremoto K; Watanabe Y; Tada N; Daida H. 2008. Deletion of the Fc receptors gamma chain preserves endothelial function affected by hypercholesterolaemia in mice fed on a high-fat diet. Cardiovasc Res 80(3):463-70. [PubMed: 18694873]  [MGI Ref ID J:161884]

Suto H; Nakae S; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2006. Mast cell-associated TNF promotes dendritic cell migration. J Immunol 176(7):4102-12. [PubMed: 16547246]  [MGI Ref ID J:129877]

Sutterwala FS; Noel GJ; Salgame P; Mosser DM. 1998. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med 188(1):217-22. [PubMed: 9653099]  [MGI Ref ID J:111539]

Syed SN; Konrad S; Wiege K; Nieswandt B; Nimmerjahn F; Schmidt RE; Gessner JE. 2009. Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. Eur J Immunol 39(12):3343-56. [PubMed: 19795417]  [MGI Ref ID J:155482]

Sylvestre D; Clynes R; Ma M; Warren H; Carroll MC; Ravetch JV. 1996. Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med 184(6):2385-92. [PubMed: 8976192]  [MGI Ref ID J:78296]

Sylvestre DL; Ravetch JV. 1996. A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity 5(4):387-90. [PubMed: 8885871]  [MGI Ref ID J:78885]

Takaya N; Katoh Y; Iwabuchi K; Hayashi I; Konishi H; Itoh S; Okumura K; Ra C; Nagaoka I; Daida H. 2005. Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 39(6):856-64. [PubMed: 16246361]  [MGI Ref ID J:112819]

Tan PS; Gavin AL; Barnes N; Sears DW; Vremec D; Shortman K; Amigorena S; Mottram PL; Hogarth PM. 2003. Unique monoclonal antibodies define expression of Fc gamma RI on macrophages and mast cell lines and demonstrate heterogeneity among subcutaneous and other dendritic cells. J Immunol 170(5):2549-56. [PubMed: 12594281]  [MGI Ref ID J:86282]

Taylor PA; Ehrhardt MJ; Roforth MM; Swedin JM; Panoskaltsis-Mortari A; Serody JS; Blazar BR. 2007. Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients. Blood 109(3):1307-15. [PubMed: 17018854]  [MGI Ref ID J:144393]

Taylor SM; Reilly MP; Schreiber AD; Chien P; Tuckosh JR; McKenzie SE. 2000. Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor. Blood 96(13):4254-60. [PubMed: 11110699]  [MGI Ref ID J:110336]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Thomas BN; Buxbaum LU. 2008. FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions. Infect Immun 76(2):623-31. [PubMed: 18070890]  [MGI Ref ID J:130336]

Thomas-Rudolph D; Du Clos TW; Snapper CM; Mold C. 2007. C-reactive protein enhances immunity to Streptococcus pneumoniae by targeting uptake to Fc gamma R on dendritic cells. J Immunol 178(11):7283-91. [PubMed: 17513778]  [MGI Ref ID J:147830]

Tomasello E; Desmoulins PO; Chemin K; Guia S; Cremer H; Ortaldo J; Love P; Kaiserlian D; Vivier E. 2000. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13(3):355-64. [PubMed: 11021533]  [MGI Ref ID J:64764]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Triulzi C; Vertuani S; Curcio C; Antognoli A; Seibt J; Akusjarvi G; Wei WZ; Cavallo F; Kiessling R. 2010. Antibody-dependent natural killer cell-mediated cytotoxicity engendered by a kinase-inactive human HER2 adenovirus-based vaccination mediates resistance to breast tumors. Cancer Res 70(19):7431-41. [PubMed: 20823150]  [MGI Ref ID J:164428]

Ugajin T; Satoh T; Kanamori T; Aritake K; Urade Y; Yokozeki H. 2011. FcepsilonRI, but Not FcgammaR, Signals Induce Prostaglandin D2 and E2 Production from Basophils. Am J Pathol 179(2):775-82. [PubMed: 21712025]  [MGI Ref ID J:174388]

Urich E; Gutcher I; Prinz M; Becher B. 2006. Autoantibody-mediated demyelination depends on complement activation but not activatory Fc-receptors. Proc Natl Acad Sci U S A 103(49):18697-702. [PubMed: 17121989]  [MGI Ref ID J:118289]

Utomo A; Cullere X; Glogauer M; Swat W; Mayadas TN. 2006. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol 177(9):6388-97. [PubMed: 17056570]  [MGI Ref ID J:140509]

Venkatesh D; Ernandez T; Rosetti F; Batal I; Cullere X; Luscinskas FW; Zhang Y; Stavrakis G; Garcia-Cardena G; Horwitz BH; Mayadas TN. 2013. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment. Immunity 38(5):1025-37. [PubMed: 23623383]  [MGI Ref ID J:203156]

Vines CM; Potter JW; Xu Y; Geahlen RL; Costello PS; Tybulewicz VL; Lowell CA; Chang PW; Gresham HD; Willman CL. 2001. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15(4):507-19. [PubMed: 11672534]  [MGI Ref ID J:110529]

Vora KA; Ravetch JV; Manser T. 1997. Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response. J Immunol 159(5):2116-24. [PubMed: 9278297]  [MGI Ref ID J:78658]

Wada T; Ishiwata K; Koseki H; Ishikura T; Ugajin T; Ohnuma N; Obata K; Ishikawa R; Yoshikawa S; Mukai K; Kawano Y; Minegishi Y; Yokozeki H; Watanabe N; Karasuyama H. 2010. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120(8):2867-75. [PubMed: 20664169]  [MGI Ref ID J:163761]

Wakayama H; Hasegawa Y; Kawabe T; Hara T; Matsuo S; Mizuno M; Takai T; Kikutani H; Shimokata K. 2000. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Eur J Immunol 30(4):1182-90. [PubMed: 10760808]  [MGI Ref ID J:61673]

Walzer T; Blery M; Chaix J; Fuseri N; Chasson L; Robbins SH; Jaeger S; Andre P; Gauthier L; Daniel L; Chemin K; Morel Y; Dalod M; Imbert J; Pierres M; Moretta A; Romagne F; Vivier E. 2007. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A 104(9):3384-9. [PubMed: 17360655]  [MGI Ref ID J:125935]

Wang H; LeBert V; Hung CY; Galles K; Saijo S; Lin X; Cole GT; Klein BS; Wuthrich M. 2014. C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol 192(3):1107-19. [PubMed: 24391211]  [MGI Ref ID J:207298]

Watanabe M; Satoh T; Yamamoto Y; Kanai Y; Karasuyama H; Yokozeki H. 2008. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol 181(8):5653-9. [PubMed: 18832724]  [MGI Ref ID J:140755]

Weng Z; Li D; Zhang L; Chen J; Ruan C; Chen G; Gartner TK; Liu J. 2010. PTEN regulates collagen-induced platelet activation. Blood 116(14):2579-81. [PubMed: 20554973]  [MGI Ref ID J:165893]

Wermeling F; Anthony RM; Brombacher F; Ravetch JV. 2013. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A 110(33):13487-91. [PubMed: 23898202]  [MGI Ref ID J:200690]

Wernersson S; Karlsson MC; Dahlstrom J; Mattsson R; Verbeek JS; Heyman B. 1999. IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol 163(2):618-22. [PubMed: 10395649]  [MGI Ref ID J:56162]

Werninghaus K; Babiak A; Gross O; Holscher C; Dietrich H; Agger EM; Mages J; Mocsai A; Schoenen H; Finger K; Nimmerjahn F; Brown GD; Kirschning C; Heit A; Andersen P; Wagner H; Ruland J; Lang R. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med 206(1):89-97. [PubMed: 19139169]  [MGI Ref ID J:144021]

Whitmer KJ; Romball CG; Weigle WO. 1997. Induction of tolerance to human gamma-globulin in FcR gamma- and Fc gammaRII-deficient mice. J Immunol 159(2):644-9. [PubMed: 9218579]  [MGI Ref ID J:110618]

Wipke BT; Wang Z; Nagengast W; Reichert DE; Allen PM. 2004. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol 172(12):7694-702. [PubMed: 15187152]  [MGI Ref ID J:90825]

Wolniak KL; Noelle RJ; Waldschmidt TJ. 2006. Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice. J Immunol 177(4):2072-9. [PubMed: 16887965]  [MGI Ref ID J:138400]

Wu Y; Torchia J; Yao W; Lane NE; Lanier LL; Nakamura MC; Humphrey MB. 2007. Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS ONE 2(7):e586. [PubMed: 17611621]  [MGI Ref ID J:129303]

Xie X; He H; Colonna M; Seya T; Takai T; Croy BA. 2005. Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod 73(3):510-8. [PubMed: 15878887]  [MGI Ref ID J:100668]

Xing D; Hage FG; Chen YF; McCrory MA; Feng W; Skibinski GA; Majid-Hassan E; Oparil S; Szalai AJ. 2008. Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent. Am J Pathol 172(1):22-30. [PubMed: 18063701]  [MGI Ref ID J:130468]

Yago T; Shao B; Miner JJ; Yao L; Klopocki AG; Maeda K; Coggeshall KM; McEver RP. 2010. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood 116(3):485-94. [PubMed: 20299514]  [MGI Ref ID J:162825]

Yamaguchi A; Katsuyama K; Nagahama K; Takai T; Aoki I; Yamanaka S. 2004. Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. J Clin Invest 113(2):200-8. [PubMed: 14722612]  [MGI Ref ID J:87617]

Yang Z; Mosser DM; Zhang X. 2007. Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. J Immunol 178(2):1077-85. [PubMed: 17202371]  [MGI Ref ID J:142619]

Yasuda K; Muto T; Kawagoe T; Matsumoto M; Sasaki Y; Matsushita K; Taki Y; Futatsugi-Yumikura S; Tsutsui H; Ishii KJ; Yoshimoto T; Akira S; Nakanishi K. 2012. Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A 109(9):3451-6. [PubMed: 22331917]  [MGI Ref ID J:182160]

Yasuda K; Richez C; Maciaszek JW; Agrawal N; Akira S; Marshak-Rothstein A; Rifkin IR. 2007. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol 178(11):6876-85. [PubMed: 17513736]  [MGI Ref ID J:147844]

Yazawa N; Hamaguchi Y; Poe JC; Tedder TF. 2005. Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proc Natl Acad Sci U S A 102(42):15178-83. [PubMed: 16217038]  [MGI Ref ID J:103745]

Yu M; Eckart MR; Morgan AA; Mukai K; Butte AJ; Tsai M; Galli SJ. 2011. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. J Clin Invest 121(8):3133-43. [PubMed: 21737883]  [MGI Ref ID J:176170]

Zarbock A; Abram CL; Hundt M; Altman A; Lowell CA; Ley K. 2008. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med 205(10):2339-47. [PubMed: 18794338]  [MGI Ref ID J:140111]

Zhang G; Peng Y; Schoenlaub L; Elliott A; Mitchell W; Zhang Y. 2013. Formalin-inactivated Coxiella burnetii phase I vaccine-induced protection depends on B cells to produce protective IgM and IgG. Infect Immun 81(6):2112-22. [PubMed: 23545296]  [MGI Ref ID J:199523]

Zhang L; Tinkle SS. 2000. Chemical activation of innate and specific immunity in contact dermatitis. J Invest Dermatol 115(2):168-76. [PubMed: 10951232]  [MGI Ref ID J:63936]

Zhang X; Majlessi L; Deriaud E; Leclerc C; Lo-Man R. 2009. Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity 31(5):761-71. [PubMed: 19913447]  [MGI Ref ID J:155296]

Zietara N; Lyszkiewicz M; Puchalka J; Pei G; Gutierrez MG; Lienenklaus S; Hobeika E; Reth M; Martins dos Santos VA; Krueger A; Weiss S. 2013. Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A 110(6):2282-7. [PubMed: 23345431]  [MGI Ref ID J:194334]

Zou Z; Schmaier AA; Cheng L; Mericko P; Dickeson SK; Stricker TP; Santoro SA; Kahn ML. 2009. Negative regulation of activated {alpha}2 integrins during thrombopoiesis. Blood 113(25):6428-39. [PubMed: 19258597]  [MGI Ref ID J:150091]

de Haij S; Jansen JH; Boross P; Beurskens FJ; Bakema JE; Bos DL; Martens A; Verbeek JS; Parren PW; van de Winkel JG; Leusen JH. 2010. In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling. Cancer Res 70(8):3209-17. [PubMed: 20354182]  [MGI Ref ID J:158966]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)