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| Mice homozygous for Jak3tm1Ljb have blocked B cell development at pre-B resulting in a significant decrease in peripheral IgM+ B cells. Proliferative responses to mitogenic signals are defective and Il2 receptor signaling is blocked. The overall phenotype results in a severely immunocompromised mouse. | |||||||||||||||
- Description
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Description
Strain Information
Former Names B6.129S4-Jak3tm1Ljb (Changed: 15-DEC-04 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N?F?+18N1F23 (11-MAR-13)
Generation DefinitionsDonating Investigator Dr. Leslie Berg, University of Massachusetts Medical Scho Appearance
black
Related Genotype: a/aDescription
Mice homozygous for the Jak3tm1Ljb mutation are viable and fertile. B cell development is blocked at pre-B resulting in a significant decrease in peripheral IgM+ B cells. The thymus is small but T cell development is relatively normal. There are increased numbers of CD4+ Cd8- cells in some homozygotes. Proliferative responses to mitogenic signals are defective and Il2 receptor signaling is blocked. The overall phenotype results in a severely immunocompromised mouse.
Control Information
| Control | ||
|---|---|---|
| 101045 B6129SF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
Phenotype
Phenotype Information
View Related Disease (OMIM) Terms
Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative (JAK3)
assigned by genotype
Jak3tm1Ljb/Jak3tm1Ljb
involves: 129S4/SvJae * C57BL/6
- immune system phenotype
- abnormal B cell morphology (MGI Ref ID J:29722)
- arrested B cell differentiation
- decreased immature B cell number
- decreased mature B cell number
- abnormal immune system physiology (MGI Ref ID J:29722)
- abnormal leukocyte physiology
- abnormal lymphocyte physiology
- abnormal T cell activation
- decreased T cell proliferation
- mitogen-induced thymocyte and splenic T cell proliferation responses are significantly reduced compared to wild-type cells (MGI Ref ID J:29722)
- decreased IgG level
- abnormal response to infection
- the LPS-induced proliferation response of spleen cells is significantly reduced (MGI Ref ID J:29722)
- abnormal splenic cell ratio
- spleens contain an increased percentage of Thy1- CD45R- Mac1- cells (MGI Ref ID J:29722)
- small Peyer's patches
- Peyer's patches are almost undetectable (MGI Ref ID J:29722)
- small lymph nodes
- peripheral lymph nodes are nearly undetectable (MGI Ref ID J:29722)
- small thymus (MGI Ref ID J:29722)
- spleen hypoplasia
- total spleen cell numbers range from 10 to 500% of wild-type controls (MGI Ref ID J:29722)
- hematopoietic system phenotype
- abnormal B cell morphology (MGI Ref ID J:29722)
- arrested B cell differentiation
- decreased immature B cell number
- decreased mature B cell number
- abnormal T cell activation
- decreased T cell proliferation
- mitogen-induced thymocyte and splenic T cell proliferation responses are significantly reduced compared to wild-type cells (MGI Ref ID J:29722)
- abnormal splenic cell ratio
- spleens contain an increased percentage of Thy1- CD45R- Mac1- cells (MGI Ref ID J:29722)
- small thymus (MGI Ref ID J:29722)
- spleen hypoplasia
- total spleen cell numbers range from 10 to 500% of wild-type controls (MGI Ref ID J:29722)
- cellular phenotype
- abnormal T cell activation
- decreased T cell proliferation
- mitogen-induced thymocyte and splenic T cell proliferation responses are significantly reduced compared to wild-type cells (MGI Ref ID J:29722)
- arrested B cell differentiation
- decreased immature B cell number
Jak3tm1Ljb/Jak3tm1Ljb
B6;129S4-Jak3tm1Ljb/J
- immune system phenotype
- abnormal dendritic cell morphology (MGI Ref ID J:123902)
- abnormal dendritic cell differentiation
- decreased myeloid dendritic cell number
- abnormal dendritic cell physiology
- in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis (MGI Ref ID J:123902)
- bone marrow-derived dendritic cells overproduce IL12 and IL10 (MGI Ref ID J:123902)
- when bone marrow-derived dendritic cells are used in an adoptive transfer model the proportion of IFNG-producing cells is increased compared to when wild-type cells are used (MGI Ref ID J:123902)
- abnormal splenic cell ratio
- reduced numbers of splenocytes (MGI Ref ID J:123902)
- decrease in the proportion and absolute number of CD11c+ dendritic, CD4+, and CD8+ cells in the spleen (MGI Ref ID J:123902)
- however, the frequency plasmacytoid dendritic cells is not significantly different from wild-type controls (MGI Ref ID J:123902)
- decreased CD4-positive T cell number
- decrease in the proportion and absolute number of CD4+ cells in the spleen (MGI Ref ID J:123902)
- decreased CD8-positive T cell number
- decrease in the proportion and absolute number of CD8+ cells in the spleen (MGI Ref ID J:123902)
- hematopoietic system phenotype
- abnormal dendritic cell morphology (MGI Ref ID J:123902)
- abnormal dendritic cell differentiation
- decreased myeloid dendritic cell number
- abnormal splenic cell ratio
- reduced numbers of splenocytes (MGI Ref ID J:123902)
- decrease in the proportion and absolute number of CD11c+ dendritic, CD4+, and CD8+ cells in the spleen (MGI Ref ID J:123902)
- however, the frequency plasmacytoid dendritic cells is not significantly different from wild-type controls (MGI Ref ID J:123902)
- decreased CD4-positive T cell number
- decrease in the proportion and absolute number of CD4+ cells in the spleen (MGI Ref ID J:123902)
- decreased CD8-positive T cell number
- decrease in the proportion and absolute number of CD8+ cells in the spleen (MGI Ref ID J:123902)
- cellular phenotype
- abnormal dendritic cell differentiation
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Jak3tm1Ljb/Jak3+
involves: 129S4/SvJae
- immune system phenotype
- abnormal leukocyte morphology
- slight increase in the number of cells classified as myeloid or premonocytic (MGI Ref ID J:56629)
- decreased lymphocyte cell number
- increased leukocyte cell number
- hematopoietic system phenotype
- abnormal leukocyte morphology
- slight increase in the number of cells classified as myeloid or premonocytic (MGI Ref ID J:56629)
- decreased lymphocyte cell number
- increased leukocyte cell number
Jak3tm1Ljb/Jak3tm1Ljb
involves: 129S4/SvJae
- immune system phenotype
- abnormal T cell physiology
- abnormal leukocyte morphology
- large increase in the number of cells classified as myeloid or premonocytic (MGI Ref ID J:56629)
- abnormal T cell differentiation
- the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (MGI Ref ID J:64861)
- both pro-T and pre-T cells have increased CD25 expression (MGI Ref ID J:64861)
- about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (MGI Ref ID J:64861)
- intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (MGI Ref ID J:64861)
- most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (MGI Ref ID J:64861)
- from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (MGI Ref ID J:64861)
- however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (MGI Ref ID J:64861)
- abnormal T cell activation
- decreased lymphocyte cell number
- absent B cells (MGI Ref ID J:128694)
- decreased thymocyte number
- in adult mice, there is about a 20-fold reduction in thymocyte numbers (MGI Ref ID J:64861)
- at E14 - E15, thymocytes are virtually undetectable (MGI Ref ID J:64861)
- at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (MGI Ref ID J:64861)
- despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (MGI Ref ID J:64861)
- increased leukocyte cell number
- abnormal myelopoiesis
- increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (MGI Ref ID J:56629)
- abnormal spleen morphology
- the general architecture of the spleen is severely disrupted (MGI Ref ID J:56629)
- abnormal spleen white pulp morphology
- enlarged spleen
- abnormal thymus cell ratio
- increase in the ratio of CD4+ to CD8+ cells (MGI Ref ID J:128694)
- absent lymph nodes (MGI Ref ID J:128694)
- chronic inflammation
- widespread infiltration of the lungs, kidneys, and liver with mononuclear cells (MGI Ref ID J:56629)
- thymus hypoplasia (MGI Ref ID J:128694)
- hematopoietic system phenotype
- abnormal erythropoiesis
- slight decrease in the number of erythroid progenitors in the bone marrow (MGI Ref ID J:56629)
- abnormal leukocyte morphology
- large increase in the number of cells classified as myeloid or premonocytic (MGI Ref ID J:56629)
- abnormal T cell differentiation
- the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (MGI Ref ID J:64861)
- both pro-T and pre-T cells have increased CD25 expression (MGI Ref ID J:64861)
- about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (MGI Ref ID J:64861)
- intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (MGI Ref ID J:64861)
- most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (MGI Ref ID J:64861)
- from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (MGI Ref ID J:64861)
- however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (MGI Ref ID J:64861)
- abnormal T cell activation
- decreased lymphocyte cell number
- absent B cells (MGI Ref ID J:128694)
- decreased thymocyte number
- in adult mice, there is about a 20-fold reduction in thymocyte numbers (MGI Ref ID J:64861)
- at E14 - E15, thymocytes are virtually undetectable (MGI Ref ID J:64861)
- at E14 only about 200 Thy+ cells are present in the thymus compared to around 20,000 in age-matched heterozygous littermates (MGI Ref ID J:64861)
- despite the deficit in progenitors, the rate of thymocyte expansion between E14 and E18 and differentiation of thymic progenitors into pro-T cells are similar to that of heterozygous littermates (MGI Ref ID J:64861)
- increased leukocyte cell number
- abnormal myelopoiesis
- increase in the number of myeloid progenitor cells in the peripheral blood and bone marrow (MGI Ref ID J:56629)
- abnormal spleen morphology
- the general architecture of the spleen is severely disrupted (MGI Ref ID J:56629)
- abnormal spleen white pulp morphology
- enlarged spleen
- abnormal thymus cell ratio
- increase in the ratio of CD4+ to CD8+ cells (MGI Ref ID J:128694)
- thymus hypoplasia (MGI Ref ID J:128694)
- cellular phenotype
- abnormal T cell differentiation
- the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found (MGI Ref ID J:64861)
- both pro-T and pre-T cells have increased CD25 expression (MGI Ref ID J:64861)
- about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 (MGI Ref ID J:64861)
- intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells (MGI Ref ID J:64861)
- most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage (MGI Ref ID J:64861)
- from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates (MGI Ref ID J:64861)
- however, by E18 T cell maturation in homozygous mice has caught up to that of their heterozygous littermates (MGI Ref ID J:64861)
- abnormal T cell activation
Jak3tm1Ljb related
Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
B, T, and NK cell deficiency
Intracellular Signaling Molecules
Mouse/Human Gene Homologs
severe combined immunodeficiency disease, autosomal recessive, T-negative/ B-positive type
Research Tools
Cancer Research
B, T, and NK cell deficiency, xenograft/transplant host
Immunology and Inflammation Research
B cell deficiency
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Jak3tm1Ljb | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Leslie J Berg | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | Jak-3-; Jak3-; | ||
| Mutation Made By | Dr. Leslie Berg, University of Massachusetts Medical Scho | ||
| Strain of Origin | 129S4/SvJae | ||
| ES Cell Line Name | J1 | ||
| ES Cell Line Strain | 129S4/SvJae | ||
| Gene Symbol and Name | Jak3, Janus kinase 3 | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK; RATJAK3; wil; willow; | ||
| Molecular Note | A neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. [MGI Ref ID J:29722] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Jak3tm1Ljb, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Thomis DC; Gurniak CB; Tivol E; Sharpe AH; Berg LJ. 1995. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270(5237):794-7. [PubMed: 7481767] [MGI Ref ID J:29722]
Additional References
Antov A; Yang L; Vig M; Baltimore D; Van Parijs L. 2003. Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance. J Immunol 171(7):3435-41. [PubMed: 14500638] [MGI Ref ID J:85631]
Soldevila G; Licona I; Salgado A; Ramirez M; Chavez R; Garcia-Zepeda E. 2004. Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology 112(2):191-200. [PubMed: 15147562] [MGI Ref ID J:90510]
Jak3tm1Ljb relatedBaird AM; Lucas JA; Berg LJ. 2000. A profound deficiency in thymic progenitor cells in mice lacking Jak3 J Immunol 165(7):3680-8. [PubMed: 11034372] [MGI Ref ID J:64861]
Bell BD; Kitajima M; Larson RP; Stoklasek TA; Dang K; Sakamoto K; Wagner KU; Reizis B; Hennighausen L; Ziegler SF. 2013. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14(4):364-71. [PubMed: 23435120] [MGI Ref ID J:194747]
Bongfen SE; Rodrigue-Gervais IG; Berghout J; Torre S; Cingolani P; Wiltshire SA; Leiva-Torres GA; Letourneau L; Sladek R; Blanchette M; Lathrop M; Behr MA; Gruenheid S; Vidal SM; Saleh M; Gros P. 2012. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS One 7(2):e31012. [PubMed: 22363534] [MGI Ref ID J:185217]
Dillon SR; Schlissel MS. 2002. Partial restoration of B cell development in Jak-3(-/-) mice achieved by co-expression of IgH and E(mu)-myc transgenes. Int Immunol 14(8):893-904. [PubMed: 12147626] [MGI Ref ID J:78457]
Garcia-Zepeda EA; Licona-Limon I; Jimenez-Solomon MF; Soldevila G. 2007. Janus kinase 3-deficient T lymphocytes have an intrinsic defect in CCR7-mediated homing to peripheral lymphoid organs. Immunology 122(2):247-60. [PubMed: 17521370] [MGI Ref ID J:125641]
Gozalo-Sanmillan S; McNally JM; Lin MY; Chambers CA; Berg LJ. 2001. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J Immunol 166(2):727-30. [PubMed: 11145642] [MGI Ref ID J:127073]
Grossman WJ; Verbsky JW; Yang L; Berg LJ; Fields LE; Chaplin DD; Ratner L. 1999. Dysregulated myelopoiesis in mice lacking Jak3. Blood 94(3):932-9. [PubMed: 10419884] [MGI Ref ID J:56629]
Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. [PubMed: 18852293] [MGI Ref ID J:141103]
Lange C; Thiersch M; Samardzija M; Burgi S; Joly S; Grimm C. 2010. LIF-dependent JAK3 activation is not essential for retinal degeneration. J Neurochem 113(5):1210-20. [PubMed: 20345762] [MGI Ref ID J:161419]
Li L; Xia Y; Nguyen A; Lai YH; Feng L; Mosmann TR; Lo D. 1999. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol 162(5):2477-87. [PubMed: 10072486] [MGI Ref ID J:112256]
Lv N; Kim EK; Song MY; Choi HN; Moon WS; Park SJ; Park JW; Kwon KB; Park BH. 2009. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res 315(12):2064-71. [PubMed: 19414010] [MGI Ref ID J:150450]
Mayack SR; Berg LJ. 2006. Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. J Immunol 176(4):2059-63. [PubMed: 16455959] [MGI Ref ID J:129213]
Rivas-Caicedo A; Soldevila G; Fortoul TI; Castell-Rodriguez A; Flores-Romo L; Garcia-Zepeda EA. 2009. Jak3 is involved in dendritic cell maturation and CCR7-dependent migration. PLoS One 4(9):e7066. [PubMed: 19759904] [MGI Ref ID J:153621]
Rochman Y; Kashyap M; Robinson GW; Sakamoto K; Gomez-Rodriguez J; Wagner KU; Leonard WJ. 2010. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A 107(45):19455-60. [PubMed: 20974963] [MGI Ref ID J:167374]
Schulteis RD; Chu H; Dai X; Chen Y; Edwards B; Haribhai D; Williams CB; Malarkannan S; Hessner MJ; Glisic-Milosavljevic S; Jana S; Kerschen EJ; Ghosh S; Wang D; Kwitek AE; Lernmark A; Gorski J; Weiler H. 2008. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood 112(13):4905-14. [PubMed: 18796632] [MGI Ref ID J:143620]
Shi M; Lin TH; Appell KC; Berg LJ. 2009. Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals. J Immunol 183(7):4493-501. [PubMed: 19734221] [MGI Ref ID J:152788]
Shi M; Lin TH; Appell KC; Berg LJ. 2008. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28(6):763-73. [PubMed: 18549798] [MGI Ref ID J:137735]
Soldevila G; Licona I; Salgado A; Ramirez M; Chavez R; Garcia-Zepeda E. 2004. Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology 112(2):191-200. [PubMed: 15147562] [MGI Ref ID J:90510]
Thomis DC; Berg LJ. 1997. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med 185(2):197-206. [PubMed: 9016869] [MGI Ref ID J:128694]
Thomis DC; Lee W; Berg LJ. 1997. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J Immunol 159(10):4708-19. [PubMed: 9366394] [MGI Ref ID J:43961]
Verbsky JW; Randolph DA; Shornick LP; Chaplin DD. 2002. Nonhematopoietic Expression of Janus Kinase 3 Is Required for Efficient Recruitment of Th2 Lymphocytes and Eosinophils in OVA-Induced Airway Inflammation. J Immunol 168(5):2475-82. [PubMed: 11859141] [MGI Ref ID J:74723]
Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106(9):3227-33. [PubMed: 16020505] [MGI Ref ID J:123902]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Breeding & Husbandry Colony is currently maintained homozygote x homozygote. Expected coat color from breeding is black or agouti. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $177.00 Female or Male Homozygous for Jak3tm1Ljb
Price per Pair (US dollars $) Pair Genotype $354.00 Homozygous for Jak3tm1Ljb x Homozygous for Jak3tm1Ljb Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $230.10 Female or Male Homozygous for Jak3tm1Ljb
Price per Pair (US dollars $) Pair Genotype $460.20 Homozygous for Jak3tm1Ljb x Homozygous for Jak3tm1Ljb Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 101045 B6129SF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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