Strain Name:

STOCK Egfrtm1Mag/J

Stock Number:

002857

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Background Strain CD1
Donor Strain 129S2 via D3 ES cell line
 
Donating InvestigatorDr. David Threadgill,   Lineberger Cancer Center 11-129

Appearance
albino
Related Genotype: unknown

Description
Mice homozygous for the Egfrtm1Mag targeted mutation are recognizable at 2 to 3 days by curly whiskers. The first coat is waved but later coats are not; vibrissae usually remain curled and the guard hairs curved. Fertile mutant females have impaired lactation.

Development
This strain was developed in the laboratory of Dr. David Threadgill at Case Western Reserve University. The 129-derived D3 ES cell line was used.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Egfr
010575   B6;SJL-Tg(tetO-Egfr*)2-9Jek/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
006926   C57BL/6J-EgfrVel/J
018473   STOCK Egfrtm1.1Tyj/J
025184   STOCK Egfrwa2/2J
View Strains carrying other alleles of Egfr     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Inflammatory Skin and Bowel Disease, Neonatal, 2; NISBD2   (EGFR)
Lung Cancer   (EGFR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Egfrtm1Mag/Egfrtm1Mag

        involves: 129S2/SvPas * CD-1
  • mortality/aging
  • complete perinatal lethality
    • on a CD-1-enriched genetic background, homozygotes die perinatally; however, survival can be extended up to P18 upon removal of wild-type littermates   (MGI Ref ID J:26833)
  • growth/size/body phenotype
  • abnormal tongue morphology
    • mutant tongues contain reduced interspersed adipose tissue   (MGI Ref ID J:26833)
    • abnormal filiform papillae morphology
      • homozygotes display abnormal filiform papillae with reduced connective tissue   (MGI Ref ID J:26833)
    • abnormal fungiform papillae morphology
      • homozygotes show a reduction in the number of fungiform papillae   (MGI Ref ID J:26833)
      • those present at P12 appear disorganized and lack identifiable taste buds   (MGI Ref ID J:26833)
  • cachexia
    • homozygous mutant pups exhibit progressive wasting; postnatal survivors are only 30-35% the weight of wild-type littermates   (MGI Ref ID J:26833)
  • postnatal growth retardation
    • homozygous mutant pups exhibit a 15% reduction in postnatal growth, despite normal birth weights   (MGI Ref ID J:26833)
  • vision/eye phenotype
  • absent eyelids
    • at E14.5-E18.5, homozygotes fail to form eyelids   (MGI Ref ID J:26833)
  • eyelids open at birth
    • homozygotes have open eyes at birth   (MGI Ref ID J:26833)
  • digestive/alimentary phenotype
  • abnormal colon morphology
    • although normal through P12, the mutant colonic epithelium displays an aberrant glandular architecture by P18   (MGI Ref ID J:26833)
    • at P18, tall disorganized branching crypt columns are occasionally found close to short rudimentary crypt columns   (MGI Ref ID J:26833)
  • abnormal esophageal epithelium morphology
    • at P12 and P18, homozygotes display decreased BrdU labeling in the basal layer of the esophagus   (MGI Ref ID J:26833)
  • abnormal tongue morphology
    • mutant tongues contain reduced interspersed adipose tissue   (MGI Ref ID J:26833)
    • abnormal filiform papillae morphology
      • homozygotes display abnormal filiform papillae with reduced connective tissue   (MGI Ref ID J:26833)
    • abnormal fungiform papillae morphology
      • homozygotes show a reduction in the number of fungiform papillae   (MGI Ref ID J:26833)
      • those present at P12 appear disorganized and lack identifiable taste buds   (MGI Ref ID J:26833)
  • liver/biliary system phenotype
  • abnormal liver morphology
    • although normal at E17.5, mutant livers show aberrant sinusoidal anatomy and abnormal vacuolizatized nuclei by P8   (MGI Ref ID J:26833)
    • abnormal hepatocyte morphology
      • by P8, mutant livers display thickened hepatocyte cords   (MGI Ref ID J:26833)
  • renal/urinary system phenotype
  • dilated kidney collecting duct
    • homozygotes exhibit cystic dilation of collecting tubules, with a flattened instead of a cuboidal epithelial lining   (MGI Ref ID J:26833)
  • homeostasis/metabolism phenotype
  • increased blood urea nitrogen level
    • at P12, homozygotes display 75 mg/dl BUN vs 26 mg/dl in wild-type littermates; BUN reaches 288 mg/dl at P18   (MGI Ref ID J:26833)
  • increased circulating creatinine level
    • at P18, homozygotes display increased serum creatinine levels relative to wild-type littermates (2.4 mg/dl vs 0.1 mg/dl, respectively)   (MGI Ref ID J:26833)
  • nervous system phenotype
  • abnormal cerebellum external granule cell layer morphology
    • after birth, homozygotes exhibit delayed migration of the EGC layer   (MGI Ref ID J:26833)
  • abnormal cerebral cortex morphology
    • at E18.5, the mutant cerebral cortex appears relatively normal; however, neuroblast migration and cortical plate formation is impaired   (MGI Ref ID J:26833)
    • at E18.5, the mutant ventricular zone is thickened while the intermediate zone is markedly thinned in some mutants   (MGI Ref ID J:26833)
    • thin cerebral cortex
      • by P18, homozygotes display atrophy of the anterior cerebral cortex, which is reduced to a thin sheet of cells   (MGI Ref ID J:26833)
  • abnormal olfactory bulb morphology
    • at E18.5, mutant olfactory bulbs appear normal in size and cell composition; however, by P14, mitral and tufted cells are nearly absent   (MGI Ref ID J:26833)
    • at P18, homozygotes show a shorter or absent molecular layer; in contrast, glomerular structures remain unaffected   (MGI Ref ID J:26833)
  • decreased Purkinje cell number
    • at E18.5 and postnatally, the mutant cerebellar plate contains fewer Purkinje cells   (MGI Ref ID J:26833)
  • decreased brain size
    • at E18.5, homozygotes display a reduction in overall brain size; cortical regions are most affected   (MGI Ref ID J:26833)
  • small cerebellum   (MGI Ref ID J:26833)
  • respiratory system phenotype
  • abnormal lung development
    • at E18.5, 2 of 8 homozygotes show slightly immature lung histology and weaker surfactant staining possibly due to overall growth retardation   (MGI Ref ID J:26833)
  • craniofacial phenotype
  • abnormal tongue morphology
    • mutant tongues contain reduced interspersed adipose tissue   (MGI Ref ID J:26833)
    • abnormal filiform papillae morphology
      • homozygotes display abnormal filiform papillae with reduced connective tissue   (MGI Ref ID J:26833)
    • abnormal fungiform papillae morphology
      • homozygotes show a reduction in the number of fungiform papillae   (MGI Ref ID J:26833)
      • those present at P12 appear disorganized and lack identifiable taste buds   (MGI Ref ID J:26833)
  • integument phenotype
  • abnormal coat appearance
    • homozygotes have a fuzzy coat   (MGI Ref ID J:26833)
    • delayed hair appearance
      • homozygotes exhibit a delay in the appearance of emerging hair   (MGI Ref ID J:26833)
  • abnormal hair follicle development
    • by P2, homozygotes show a decline in interfollicular epidermal proliferation, reaching only 38% of the wild-type labeling index at P8   (MGI Ref ID J:26833)
  • abnormal hair follicle inner root sheath morphology
    • by P5, the mutant inner root sheath display premature hair keratinization and maturation   (MGI Ref ID J:26833)
  • abnormal hair follicle orientation
    • by P5, mutant hair follicles appear disoriented   (MGI Ref ID J:26833)
  • abnormal hair shaft morphology
    • by P5, the mutant hair shaft shows premature separation from the inner root sheath   (MGI Ref ID J:26833)
  • curly vibrissae
    • mutant whiskers are fragile and appear to curl anteriorly   (MGI Ref ID J:26833)
  • distorted hair follicle pattern
    • by P5, mutant hair follicles are abnormally placed   (MGI Ref ID J:26833)
  • wavy vibrissae
    • homozygous mutant pups display rudimentary waved whiskers   (MGI Ref ID J:26833)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Egfrtm1Mag/Egfrtm1Mag

        involves: 129S2/SvPas * CF1
  • mortality/aging
  • partial embryonic lethality between implantation and somite formation
    • on a CF1-enriched genetic background, homozygotes die before E7.5; only 2% of homozygotes are obtained at E6.5   (MGI Ref ID J:26833)
  • embryogenesis phenotype
  • abnormal inner cell mass morphology
    • at E4.5-E4.8, 6 of 32 homozygotes exhibit small, loosely arranged inner cell masses with no distinct endoderm   (MGI Ref ID J:26833)
    • at E5.1-E5.5, 13 of 61 mutant embryos are collapsed; by E6.5, 8 of 31 decidua lack an embryo and are filled with maternal blood   (MGI Ref ID J:26833)

Egfrtm1Mag/Egfrtm1Mag

        involves: 129/Sv * 129S2/SvPas
  • mortality/aging
  • complete embryonic lethality at implantation
    • homozygotes exhibit peri-implantation lethality on a CF1 background   (MGI Ref ID J:26833)
  • complete embryonic lethality during organogenesis
    • on a 129/Sv-enriched genetic background, homozygotes die at midgestation with resorbing embryos evident at E12.5-E13.5   (MGI Ref ID J:26833)
  • complete perinatal lethality
    • homozygotes exhibit perinatal lethality on a CD-1 background   (MGI Ref ID J:26833)
  • embryogenesis phenotype
  • abnormal placenta labyrinth morphology
    • at E12.5-E13.5, the labyrinthine trophoblast appears disorganized and hypoplastic   (MGI Ref ID J:26833)
    • in contrast, the organization and cell number of the trophoblast giant-cell layer is unremarkable   (MGI Ref ID J:26833)
  • decreased spongiotrophoblast size
    • at E12.5-E13.5, the mutant spongiotrophoblast is significantly reduced   (MGI Ref ID J:26833)
  • decreased trophoblast giant cell number
    • at E12.5-E13.5, the labyrinthine trophoblast cell number is reduced   (MGI Ref ID J:26833)
  • small placenta
    • at E12.5-E13.5, mutant placentas are smaller than wild-type   (MGI Ref ID J:26833)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Egfrtm1Mag related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Internal/Organ Defects
      kidney, brain, liver, GI

Endocrine Deficiency Research
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Internal/Organ Research
Kidney Defects
Liver Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Egfrtm1Mag
Allele Name targeted mutation 1, Terry Magnuson
Allele Type Targeted (Null/Knockout)
Common Name(s) EGFR-; Egfrm1Cwr; ErbB1-;
Mutation Made ByDr. Terry Magnuson,   UNC-Chapel Hill
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Egfr, epidermal growth factor receptor
Chromosome 11
Gene Common Name(s) 9030024J15Rik; AI552599; ERBB; ERBB1; ErbB-1; Erbb; Errb1; Errp; HER1; NISBD2; PIG61; RIKEN cDNA 9030024J15 gene; Wa5; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian erythroblastosis oncogene B; expressed sequence AI552599; mENA; wa-2; wa2; waved 2; waved 5;
Molecular Note A neomycin resistance cassette replaced 155 bp containing part of exon 2. Aberrant splicing of the targeted exon was detected joining exon 1 to either exon 3 or exon 5. The former splicing event creates a nonsense protein. Although the latter splicing event produes a truncated mRNA, no protein or phosphorylation activity was detectable. [MGI Ref ID J:26833]

Genotyping

Genotyping Information

Genotyping Protocols

Egfrtm1Mag, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Egfrtm1Mag related

Chen B; Bronson RT; Klaman LD; Hampton TG; Wang JF; Green PJ; Magnuson T; Douglas PS; Morgan JP; Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24(3):296-9. [PubMed: 10700187]  [MGI Ref ID J:60750]

Dackor J; Strunk KE; Wehmeyer MM; Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos. Placenta 28(11-12):1211-8. [PubMed: 17822758]  [MGI Ref ID J:141339]

Dise RS; Frey MR; Whitehead RH; Polk DB. 2008. Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 294(1):G276-85. [PubMed: 17991704]  [MGI Ref ID J:130505]

Dlugosz AA; Hansen L; Cheng C; Alexander N; Denning MF; Threadgill DW ; Magnuson T ; Coffey RJ Jr ; Yuspa SH. 1997. Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Res 57(15):3180-8. [PubMed: 9242447]  [MGI Ref ID J:42403]

El-Abaseri TB; Fuhrman J; Trempus C; Shendrik I; Tennant RW; Hansen LA. 2005. Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor. Cancer Res 65(9):3958-65. [PubMed: 15867397]  [MGI Ref ID J:98332]

El-Abaseri TB; Putta S; Hansen LA. 2006. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27(2):225-31. [PubMed: 16123117]  [MGI Ref ID J:105099]

Gallego MI; Binart N; Robinson GW; Okagaki R; Coschigano KT; Perry J; Kopchick JJ; Oka T; Kelly PA; Hennighausen L. 2001. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 229(1):163-75. [PubMed: 11133161]  [MGI Ref ID J:66900]

Hansen LA; Alexander N; Hogan ME; Sundberg JP; Dlugosz A; Threadgill DW ; Magnuson T ; Yuspa SH. 1997. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol 150(6):1959-75. [PubMed: 9176390]  [MGI Ref ID J:40807]

Hansen LA; Woodson RL 2nd; Holbus S; Strain K; Lo YC; Yuspa SH. 2000. The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors Cancer Res 60(13):3328-32. [PubMed: 10910032]  [MGI Ref ID J:63567]

Hayakawa-Yano Y; Nishida K; Fukami S; Gotoh Y; Hirano T; Nakagawa T; Shimazaki T; Okano H. 2007. Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord. Stem Cells 25(6):1410-22. [PubMed: 17332510]  [MGI Ref ID J:123565]

Jackson LF; Qiu TH; Sunnarborg SW; Chang A; Zhang C; Patterson C; Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22(11):2704-16. [PubMed: 12773386]  [MGI Ref ID J:83820]

Lee TC; Threadgill DW. 2009. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 47(2):85-92. [PubMed: 19115345]  [MGI Ref ID J:145161]

Leinster VH; Joy MT; Vuononvirta RE; Bolsover SR; Anderson PN. 2013. ErbB1 epidermal growth factor receptor is a valid target for reducing the effects of multiple inhibitors of axonal regeneration. Exp Neurol 239:82-90. [PubMed: 23022459]  [MGI Ref ID J:196995]

Lillien L; Gulacsi A. 2006. Environmental signals elicit multiple responses in dorsal telencephalic progenitors by threshold-dependent mechanisms. Cereb Cortex 16 Suppl 1:i74-81. [PubMed: 16766711]  [MGI Ref ID J:174485]

Liu B; Xia X; Zhu F; Park E; Carbajal S; Kiguchi K; DiGiovanni J; Fischer SM; Hu Y. 2008. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25. [PubMed: 18772111]  [MGI Ref ID J:141162]

Maklad A; Nicolai JR; Bichsel KJ; Evenson JE; Lee TC; Threadgill DW; Hansen LA. 2009. The EGFR is required for proper innervation to the skin. J Invest Dermatol 129(3):690-8. [PubMed: 18830272]  [MGI Ref ID J:145069]

Mascia F; Cataisson C; Lee TC; Threadgill D; Mariani V; Amerio P; Chandrasekhara C; Souto Adeva G; Girolomoni G; Yuspa SH; Pastore S. 2010. EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. J Invest Dermatol 130(3):682-93. [PubMed: 19890352]  [MGI Ref ID J:159552]

Repertinger SK; Campagnaro E; Fuhrman J; El-Abaseri T; Yuspa SH; Hansen LA. 2004. EGFR enhances early healing after cutaneous incisional wounding. J Invest Dermatol 123(5):982-9. [PubMed: 15482488]  [MGI Ref ID J:120140]

Saito K; Horiuchi K; Kimura T; Mizuno S; Yoda M; Morioka H; Akiyama H; Threadgill D; Okada Y; Toyama Y; Sato K. 2013. Conditional inactivation of TNFalpha-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS One 8(1):e54853. [PubMed: 23349978]  [MGI Ref ID J:195804]

Schneider MR; Werner S; Paus R; Wolf E. 2008. Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol 173(1):14-24. [PubMed: 18556782]  [MGI Ref ID J:137366]

Strunk KE; Amann V; Threadgill DW. 2004. Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned. Genetics 167(4):1821-32. [PubMed: 15342520]  [MGI Ref ID J:92345]

Sun H; Oakley B. 2002. Development of anterior gustatory epithelia in the palate and tongue requires epidermal growth factor receptor. Dev Biol 242(1):31-43. [PubMed: 11795938]  [MGI Ref ID J:74312]

Threadgill DW; Dlugosz AA; Hansen LA; Tennenbaum T; Lichti U; Yee D; LaMantia C; Mourton T; Herrup K; Harris RC; Barnard JA; Yuspa SH; Coffey RJ; Magnuson T. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269(5221):230-4. [PubMed: 7618084]  [MGI Ref ID J:26833]

Wiesen JF; Young P; Werb Z; Cunha GR. 1999. Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126(2):335-44. [PubMed: 9847247]  [MGI Ref ID J:51436]

Yamaoka T; Yan F; Cao H; Hobbs SS; Dise RS; Tong W; Polk DB. 2008. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 105(33):11772-7. [PubMed: 18701712]  [MGI Ref ID J:138989]

Zhang Z; Pascuet E; Hueber PA; Chu L; Bichet DG; Lee TC; Threadgill DW; Goodyer P. 2010. Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. J Am Soc Nephrol 21(4):573-8. [PubMed: 20133479]  [MGI Ref ID J:185851]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is maintained by mating heterozygous mice with normal wildtype siblings. The mutation has been put on several genetic backgrounds, each of which displays a different phenotype. It is maintained on both inbred 129 and outbred CD1 genetic backgrounds. Expected coat color from breeding:Albino

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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