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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names STOCK Tg(balancer1)2Cgn/J (Changed: 06-MAR-06 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation +N2
Generation DefinitionsDonating Investigator Klaus Rajewsky, Max-Delbruck-Ctr. for Molecular Medicine Description
These transgenic mice carry the Cre recombinase gene under the control of the rat nestin promoter. When crossed with a strain carrying a gene flanked by loxP sites, partial deletion of the loxP-flanked allele occurs before embryonic day 10.5 and is detectable in all adult organs examined including germ line cells. Because of the partial deletion, these balancer1 cre transgenic mice, as well as the balancer2 cre transgenic mice (Stock No. 002859), may be used to generate mosaic mice consisting of cells that are either wildtype or mutant for the gene of interest. The proportion of cells that carry the mutant allele varies between tissues and between individual mice. In cases where deletion of a particular gene is lethal, the generation of mosaic mice using these strains can bypass lethality in some mosaic individuals. The balancer2 line induces more variable deletion of loxP-flanked genes than the balancer1 line.Development
The transgene contains the gene for Cre recombinase under the control of the rat nestin promoter and second intron enhancer. The "SLNE4c" construct was used. B6CBAF2 embryos were injected. This strain was submitted on a mixed C57BL/6, CBA, BALB/c, 129 background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Nes
002859 STOCK Tg(Nes-cre)2Wme/J View Strains carrying other alleles of Nes (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Reproductive Biology Research
Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Nes-cre)1Wme | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Werner Muller | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Bal1 cre; Nestin-Cre; SLNE4c; Tg(balancer1)2Cgn; TgN(balancer1)1Cgn; TgN(balancer1)2Cgn; bal1; balancer1; | ||
| Mutation Made By | Ulrich Betz, Business Group Pharma/Research | ||
| Strain of Origin | (C57BL/6 x CBA)F2 | ||
| Site of Expression | induces variable mosaicism/partial deletion of loxP-flanked alleles before embryonic day 10.5 and in all adult organs (including germline), producing mosaic mice consisting of cells that are either wildtype or mutant for the gene of interest | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Nes, nestin, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Nes-cre)1Wme, transgene insertion 1, Werner Muller | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(balancer1)2Cgn; TgN(balancer1)1Cgn; TgN(balancer1)2Cgn; bal1; balancer1; | ||
| Driver Note | Nes | ||
| General Note | Mice carrying this "balancer 1" transgene show less variability and instability in their generation of mosaics than do transgenic mice carrying the "balancer 2" transgene. | ||
| Molecular Note | The transgenic construct contained a nestin promoter followed by cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included upstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of cre in transgenic mice. Variable mosaicism/partial deletion of loxP-flanked alleles occurs before embryonic day 10.5, and it is detectable in all adult organs examined including germ line cells. [MGI Ref ID J:67926] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Betz UA; Vosshenrich CA; Rajewsky K; Muller W. 1996. Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr Biol 6(10):1307-16. [PubMed: 8939573] [MGI Ref ID J:67926]
Additional References
Alonzi T; Middleton G; Wyatt S; Buchman V; Betz UA; Muller W; Musiani P; Poli V; Davies AM. 2001. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci 18(3):270-82. [PubMed: 11591128] [MGI Ref ID J:86898]
Hallonet M; Kaestner KH; Martin-Parras L; Sasaki H; Betz UA; Ang SL. 2002. Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants. Dev Biol 243(1):20-33. [PubMed: 11846474] [MGI Ref ID J:75055]
Tg(Nes-cre)1Wme relatedAlonzi T; Middleton G; Wyatt S; Buchman V; Betz UA; Muller W; Musiani P; Poli V; Davies AM. 2001. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci 18(3):270-82. [PubMed: 11591128] [MGI Ref ID J:86898]
Arenkiel BR; Klein ME; Davison IG; Katz LC; Ehlers MD. 2008. Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat Methods 5(4):299-302. [PubMed: 18327266] [MGI Ref ID J:136582]
Baranes K; Raz-Prag D; Nitzan A; Galron R; Ashery-Padan R; Rotenstreich Y; Assaf Y; Shiloh Y; Wang ZQ; Barzilai A; Solomon AS. 2009. Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp Neurol 218(1):24-32. [PubMed: 19345213] [MGI Ref ID J:150471]
Behrens A; Haigh J; Mechta-Grigoriou F; Nagy A; Yaniv M; Wagner EF. 2003. Impaired intervertebral disc formation in the absence of Jun. Development 130(1):103-9. [PubMed: 12441295] [MGI Ref ID J:80022]
Ben-Haim N; Lu C; Guzman-Ayala M; Pescatore L; Mesnard D; Bischofberger M; Naef F; Robertson EJ; Constam DB. 2006. The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell 11(3):313-23. [PubMed: 16950123] [MGI Ref ID J:112799]
Betz UA; Bloch W; van den Broek M; Yoshida K; Taga T; Kishimoto T; Addicks K; Rajewsky K; Muller W. 1998. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med 188(10):1955-65. [PubMed: 9815272] [MGI Ref ID J:67677]
Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. [PubMed: 20362536] [MGI Ref ID J:158953]
Bourteele S; Oesterle K; Weinzierl AO; Paxian S; Riemann M; Schmid RM; Planz O. 2007. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Cell Microbiol 9(9):2202-17. [PubMed: 17573907] [MGI Ref ID J:148571]
Chi MN; Auriol J; Jegou B; Kontoyiannis DL; Turner JM; de Rooij DG; Morello D. 2011. The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Mol Biol Cell 22(16):2875-2885. [PubMed: 21737689] [MGI Ref ID J:175695]
Ciraolo E; Iezzi M; Marone R; Marengo S; Curcio C; Costa C; Azzolino O; Gonella C; Rubinetto C; Wu H; Dastru W; Martin EL; Silengo L; Altruda F; Turco E; Lanzetti L; Musiani P; Ruckle T; Rommel C; Backer JM; Forni G; Wymann MP; Hirsch E. 2008. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal 1(36):ra3. [PubMed: 18780892] [MGI Ref ID J:152332]
Collins BJ; Deak M; Murray-Tait V; Storey KG; Alessi DR. 2005. In vivo role of the phosphate groove of PDK1 defined by knockin mutation. J Cell Sci 118(Pt 21):5023-34. [PubMed: 16219676] [MGI Ref ID J:102388]
Dar I; Yosha G; Elfassy R; Galron R; Wang ZQ; Shiloh Y; Barzilai A. 2011. Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum. J Biol Chem 286(17):15361-76. [PubMed: 21300797] [MGI Ref ID J:172097]
Ducommun S; Wang HY; Sakamoto K; MacKintosh C; Chen S. 2012. Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. Am J Physiol Endocrinol Metab 302(9):E1036-43. [PubMed: 22318952] [MGI Ref ID J:186867]
Forni PE; Scuoppo C; Imayoshi I; Taulli R; Dastru W; Sala V; Betz UA; Muzzi P; Martinuzzi D; Vercelli AE; Kageyama R; Ponzetto C. 2006. High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 26(37):9593-602. [PubMed: 16971543] [MGI Ref ID J:112466]
Frappart PO; Tong WM; Demuth I; Radovanovic I; Herceg Z; Aguzzi A; Digweed M; Wang ZQ. 2005. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 11(6):538-44. [PubMed: 15821748] [MGI Ref ID J:98316]
Friedman LG; Lachenmayer ML; Wang J; He L; Poulose SM; Komatsu M; Holstein GR; Yue Z. 2012. Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of alpha-Synuclein and LRRK2 in the Brain. J Neurosci 32(22):7585-93. [PubMed: 22649237] [MGI Ref ID J:184970]
Fritzsch B; Dillard M; Lavado A; Harvey NL; Jahan I. 2010. Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS One 5(2):e9377. [PubMed: 20186345] [MGI Ref ID J:157908]
Hallonet M; Kaestner KH; Martin-Parras L; Sasaki H; Betz UA; Ang SL. 2002. Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants. Dev Biol 243(1):20-33. [PubMed: 11846474] [MGI Ref ID J:75055]
Inta I; Paxian S; Maegele I; Zhang W; Pizzi M; Spano P; Sarnico I; Muhammad S; Herrmann O; Inta D; Baumann B; Liou HC; Schmid RM; Schwaninger M. 2006. Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. J Neurosci 26(50):12896-903. [PubMed: 17167080] [MGI Ref ID J:144659]
Koike M; Shibata M; Tadakoshi M; Gotoh K; Komatsu M; Waguri S; Kawahara N; Kuida K; Nagata S; Kominami E; Tanaka K; Uchiyama Y. 2008. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172(2):454-69. [PubMed: 18187572] [MGI Ref ID J:131320]
Komatsu M; Waguri S; Chiba T; Murata S; Iwata J; Tanida I; Ueno T; Koike M; Uchiyama Y; Kominami E; Tanaka K. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441(7095):880-4. [PubMed: 16625205] [MGI Ref ID J:110051]
Komatsu M; Waguri S; Koike M; Sou YS; Ueno T; Hara T; Mizushima N; Iwata J; Ezaki J; Murata S; Hamazaki J; Nishito Y; Iemura S; Natsume T; Yanagawa T; Uwayama J; Warabi E; Yoshida H; Ishii T; Kobayashi A; Yamamoto M; Yue Z; Uchiyama Y; Kominami E; TanakaK. 2007. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6):1149-63. [PubMed: 18083104] [MGI Ref ID J:130839]
Lange A; Wickstrom SA; Jakobson M; Zent R; Sainio K; Fassler R. 2009. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461(7266):1002-6. [PubMed: 19829382] [MGI Ref ID J:154054]
Lavado A; Lagutin OV; Chow LM; Baker SJ; Oliver G. 2010. Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol 8(8):. [PubMed: 20808958] [MGI Ref ID J:166777]
Lavado A; Oliver G. 2011. Six3 is required for ependymal cell maturation. Development 138(24):5291-300. [PubMed: 22071110] [MGI Ref ID J:178674]
Lu Z; Marcelin G; Bauzon F; Wang H; Fu H; Dun SL; Zhao H; Li X; Jo YH; Wardlaw S; Dun N; Chua S Jr; Zhu L. 2013. pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J 32(6):844-57. [PubMed: 23403926] [MGI Ref ID J:195318]
Ma X; Takeda K; Singh A; Yu ZX; Zerfas P; Blount A; Liu C; Towbin JA; Schneider MD; Adelstein RS; Wei Q. 2009. Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice. Circ Res 105(11):1102-9. [PubMed: 19815823] [MGI Ref ID J:170148]
Marino G; Fernandez AF; Cabrera S; Lundberg YW; Cabanillas R; Rodriguez F; Salvador-Montoliu N; Vega JA; Germana A; Fueyo A; Freije JM; Lopez-Otin C. 2010. Autophagy is essential for mouse sense of balance. J Clin Invest 120(7):2331-44. [PubMed: 20577052] [MGI Ref ID J:163712]
Milosevic J; Maisel M; Wegner F; Leuchtenberger J; Wenger RH; Gerlach M; Storch A; Schwarz J. 2007. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci 27(2):412-21. [PubMed: 17215402] [MGI Ref ID J:117302]
Okada S; Nakamura M; Katoh H; Miyao T; Shimazaki T; Ishii K; Yamane J; Yoshimura A; Iwamoto Y; Toyama Y; Okano H. 2006. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12(7):829-34. [PubMed: 16783372] [MGI Ref ID J:111976]
Olsan EE; Mukherjee S; Wulkersdorfer B; Shillingford JM; Giovannone AJ; Todorov G; Song X; Pei Y; Weimbs T. 2011. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A 108(44):18067-72. [PubMed: 22025716] [MGI Ref ID J:180251]
Pearce LR; Sommer EM; Sakamoto K; Wullschleger S; Alessi DR. 2011. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J 436(1):169-79. [PubMed: 21413931] [MGI Ref ID J:172256]
Shillingford JM; Murcia NS; Larson CH; Low SH; Hedgepeth R; Brown N; Flask CA; Novick AC; Goldfarb DA; Kramer-Zucker A; Walz G; Piontek KB; Germino GG; Weimbs T. 2006. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A 103(14):5466-71. [PubMed: 16567633] [MGI Ref ID J:108293]
Sklyarova T; Bonne S; D'Hooge P; Denecker G; Goossens S; De Rycke R; Borgonie G; Bosl M; van Roy F; van Hengel J. 2008. Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol 128(6):1375-85. [PubMed: 18079750] [MGI Ref ID J:136451]
Song MR; Shirasaki R; Cai CL; Ruiz EC; Evans SM; Lee SK; Pfaff SL. 2006. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development 133(24):4945-55. [PubMed: 17119020] [MGI Ref ID J:119655]
Song MR; Sun Y; Bryson A; Gill GN; Evans SM; Pfaff SL. 2009. Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development 136(17):2923-32. [PubMed: 19666821] [MGI Ref ID J:152175]
Souabni A; Jochum W; Busslinger M. 2007. Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood 109(1):281-9. [PubMed: 16968900] [MGI Ref ID J:118111]
Talbot JJ; Shillingford JM; Vasanth S; Doerr N; Mukherjee S; Kinter MT; Watnick T; Weimbs T. 2011. Polycystin-1 regulates STAT activity by a dual mechanism. Proc Natl Acad Sci U S A 108(19):7985-90. [PubMed: 21518865] [MGI Ref ID J:172196]
Wang HY; Ducommun S; Quan C; Xie B; Li M; Wasserman DH; Sakamoto K; Mackintosh C; Chen S. 2013. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J 449(2):479-89. [PubMed: 23078342] [MGI Ref ID J:194026]
Yamamoto N; Tanigaki K; Han H; Hiai H; Honjo T. 2003. Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells. Curr Biol 13(4):333-8. [PubMed: 12593800] [MGI Ref ID J:82337]
Yamasaki T; Kawasaki H; Arakawa S; Shimizu K; Shimizu S; Reiner O; Okano H; Nishina S; Azuma N; Penninger JM; Katada T; Nishina H. 2011. Stress-Activated Protein Kinase MKK7 Regulates Axon Elongation in the Developing Cerebral Cortex. J Neurosci 31(46):16872-16883. [PubMed: 22090513] [MGI Ref ID J:177905]
Yang YG; Frappart PO; Frappart L; Wang ZQ; Tong WM. 2006. A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. DNA Repair (Amst) 5(8):885-93. [PubMed: 16790366] [MGI Ref ID J:112192]
Zhang N; Fu Z; Linke S; Chicher J; Gorman JJ; Visk D; Haddad GG; Poellinger L; Peet DJ; Powell F; Johnson RS. 2010. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 11(5):364-78. [PubMed: 20399150] [MGI Ref ID J:160941]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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