Strain Name:

FVB.129S2(B6)-Trp53tm1Tyj/J

Stock Number:

002899

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain FVB/NJ
Donor Strain 129S2 via D3 ES cell line
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
albino
Related Genotype: Tyrc/Tyrc

Description
Mice homozygous for the Trp53tm1Tyj mutation show no visible phenotype but most develop tumors (principally lymphomas and sarcomas) at 3-6 months of age. Heterozygous mice develop tumors at about 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome, a form of familial breast cancer with mutations in TRP53. Homozygous mice may produce a litter before succumbing to tumors.

Development
The Trp53tm1Tyj mutant strain was developed in the laboratory of Dr. Tyler Jacks at the Center for Cancer Research at the Massachusetts Institute of Technology. The 129-derived D3 ES cell line was used. The FVB/J strain was produced by backcrossing the Trp53tm1Tyj mutation 5 times to FVB/J mice.

Control Information

  Control
   Wild-type from the colony
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Trp53tm1Tyj     (7 strains)

View Strains carrying other alleles of Trp53     (20 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Li-Fraumeni Syndrome 1; LFS1
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Adrenocortical Carcinoma, Hereditary; ADCC   (TP53)
Basal Cell Carcinoma, Susceptibility to, 7; BCC7   (TP53)
Breast Cancer   (TP53)
Colorectal Cancer; CRC   (TP53)
Glioma Susceptibility 1; GLM1   (TP53)
Hepatocellular Carcinoma   (TP53)
Nasopharyngeal Carcinoma   (TP53)
Osteogenic Sarcoma   (TP53)
Pancreatic Cancer   (TP53)
Papilloma of Choroid Plexus; CPP   (TP53)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Trp53tm1Tyj/Trp53+

        involves: 129S2/SvPas * C57BL/6
  • mortality/aging
  • premature death
    • 28% of mutants die by 17 months of age due to tumors   (MGI Ref ID J:17728)
    • heterozygous mutants die between 150 to 750 days after birth   (MGI Ref ID J:95318)
  • tumorigenesis
  • altered tumor morphology
    • tumors show loss of heterozygosity for Trp53   (MGI Ref ID J:17728)
  • increased tumor incidence
    • age of onset 9 months   (MGI Ref ID J:17728)
    • increased adenoma incidence
      • 5.9% incidence   (MGI Ref ID J:72391)
    • increased carcinoma incidence
      • 35% incidence of carcinomas   (MGI Ref ID J:72391)
      • 2.9% incidence of pancreatic adenocarcinomas   (MGI Ref ID J:72391)
      • 12% of heterozygous mutants developed carcinomas, which are rare in homozygotes   (MGI Ref ID J:95318)
      • increased adenocarcinoma incidence
        • 18% incidence   (MGI Ref ID J:72391)
        • increased lung adenocarcinoma incidence
          • 12% incidence   (MGI Ref ID J:72391)
        • increased mammary adenocarcinoma incidence
          • 2.9% incidence   (MGI Ref ID J:72391)
      • increased squamous cell carcinoma incidence
        • 18% incidence of ear squamous cell carcinoma   (MGI Ref ID J:72391)
    • increased lymphoma incidence
      • 32% incidence   (MGI Ref ID J:72391)
      • 25% of mutants exhibit lymphomas   (MGI Ref ID J:17728)
      • 32% of heterozygous mutants developed lymphomas   (MGI Ref ID J:95318)
      • increased histiocytic sarcoma incidence
        • 15% incidence   (MGI Ref ID J:72391)
    • increased pancreas tumor incidence
      • 2.9% incidence of pancreatic adenocarcinomas   (MGI Ref ID J:72391)
    • increased sarcoma incidence
      • 56% incidence of sarcomas   (MGI Ref ID J:72391)
      • 2.9% incidence of undifferentiated sarcomas   (MGI Ref ID J:72391)
      • 57% of mutants exhibit sarcomas   (MGI Ref ID J:17728)
      • 56% of heterozygous mutants developed sarcomas   (MGI Ref ID J:95318)
      • increased fibrosarcoma incidence   (MGI Ref ID J:17728)
      • increased hemangiosarcoma incidence   (MGI Ref ID J:17728)
        • 8.8% incidence   (MGI Ref ID J:72391)
      • increased histiocytic sarcoma incidence
        • 15% incidence   (MGI Ref ID J:72391)
      • increased leiomyosarcoma incidence   (MGI Ref ID J:17728)
      • increased osteosarcoma incidence   (MGI Ref ID J:17728)
        • 29% incidence   (MGI Ref ID J:72391)
      • increased rhabdomyosarcoma incidence   (MGI Ref ID J:17728)
  • digestive/alimentary phenotype
  • gastric polyps
    • 2.9% incidence of stomach polyps   (MGI Ref ID J:72391)
  • intestine polyps
    • 2.9% incidence of small intestinal polyps   (MGI Ref ID J:72391)

Trp53tm1Tyj/Trp53+

        involves: 129/Sv * C57BL/6
  • mortality/aging
  • premature death
    • less than 5% of mice live past two years due to cancerous tumors   (MGI Ref ID J:135509)
  • tumorigenesis
  • increased tumor incidence
    • over 95% of mice have tumors by 2 years of age   (MGI Ref ID J:135509)
    • increased leukemia incidence
      • is observed in 2.6% of mice by 24 months of age   (MGI Ref ID J:135509)
    • increased lymphoma incidence
      • is observed in 18.4% of mice by 24 months of age   (MGI Ref ID J:135509)

Trp53tm1Tyj/Trp53+

        involves: 129S2/SvPas
  • mortality/aging
  • premature death
    • mean life span is 15.4 months   (MGI Ref ID J:95316)
  • tumorigenesis
  • increased tumor incidence
    • 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes   (MGI Ref ID J:95316)
    • increased carcinoma incidence
      • 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma   (MGI Ref ID J:95316)
    • increased incidence of tumors by chemical induction
      • 12 of 45 mice treated with 2-AAF develop urinary bladder tumors   (MGI Ref ID J:170769)
    • increased urinary system tumor incidence
      • 12 of 45 mice treated with 2-AAF develop urinary bladder tumors   (MGI Ref ID J:170769)
  • cellular phenotype
  • decreased thymocyte apoptosis
    • in response to irradiation   (MGI Ref ID J:158953)
  • increased cell proliferation
    • a larger fraction of MEFs are in S phase compared to wild-type mice   (MGI Ref ID J:95316)
  • hematopoietic system phenotype
  • abnormal hematopoietic system physiology
    • hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice   (MGI Ref ID J:158953)
    • however, no competitive advantage is observed over similarly treated Cdkn2atm2.1Rdp cells in irradiation chimera experiments   (MGI Ref ID J:158953)
    • decreased thymocyte apoptosis
      • in response to irradiation   (MGI Ref ID J:158953)
  • immune system phenotype
  • decreased thymocyte apoptosis
    • in response to irradiation   (MGI Ref ID J:158953)
  • homeostasis/metabolism phenotype
  • increased incidence of tumors by chemical induction
    • 12 of 45 mice treated with 2-AAF develop urinary bladder tumors   (MGI Ref ID J:170769)
  • endocrine/exocrine gland phenotype
  • decreased thymocyte apoptosis
    • in response to irradiation   (MGI Ref ID J:158953)

Trp53tm1Tyj/Trp53+

        involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
  • mortality/aging
  • decreased survivor rate
    • 50% survival at 63 weeks   (MGI Ref ID J:109193)

Trp53tm1Tyj/Trp53+

        involves: 129S2/SvPas * BALB/cJ * C57BL/6
  • tumorigenesis
  • abnormal tumor incidence
    • 42.8% of mice (6 of 14) develop thymic lymphomas after exposure to ionizing radiation   (MGI Ref ID J:191827)

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas * C57BL/6
  • mortality/aging
  • partial preweaning lethality
    • 16.6% rather than the expected 25% of mutants are observed at weaning, indicating partial lethality either during embryogenesis or after birth but before weaning   (MGI Ref ID J:17728)
  • premature death
    • average life span 160 days   (MGI Ref ID J:72391)
    • most die by 6 months of age   (MGI Ref ID J:17728)
    • homozygous mutants die between ~50 to 250 days after birth   (MGI Ref ID J:95318)
    • 90% succumb to tumors and die by 7 months of age   (MGI Ref ID J:87501)
  • tumorigenesis
  • increased tumor incidence   (MGI Ref ID J:72391)
    • predominantly lymphomas with sarcomas and teratomas   (MGI Ref ID J:17728)
    • increased carcinoma incidence
      • 3.3% incidence   (MGI Ref ID J:72391)
      • increased squamous cell carcinoma incidence
        • 3.3% incidence of stomach squamous cell carcinoma   (MGI Ref ID J:72391)
    • increased hemangioma incidence
      • 3.3% incidence   (MGI Ref ID J:72391)
    • increased lymphoma incidence
      • 70% incidence   (MGI Ref ID J:72391)
      • 71% of mice develop lymphoma, usually affecting the thymus   (MGI Ref ID J:17728)
      • 56% of homozygous nulls developed lymphomas   (MGI Ref ID J:95318)
      • increased T cell derived lymphoma incidence
        • most lymphomas are thymic lymphomas   (MGI Ref ID J:17728)
        • 75% of observed tumors are thymic lymphomas   (MGI Ref ID J:87501)
    • increased sarcoma incidence   (MGI Ref ID J:17728)
      • 50% incidence   (MGI Ref ID J:72391)
      • 40% of homozygous nulls developed sarcomas   (MGI Ref ID J:95318)
      • increased fibrosarcoma incidence
        • 13% incidence   (MGI Ref ID J:72391)
      • increased hemangiosarcoma incidence   (MGI Ref ID J:17728)
        • 20% incidence   (MGI Ref ID J:72391)
      • increased osteosarcoma incidence   (MGI Ref ID J:17728)
        • 13% incidence   (MGI Ref ID J:72391)
      • increased rhabdomyosarcoma incidence   (MGI Ref ID J:17728)
    • increased teratoma incidence   (MGI Ref ID J:17728)
  • cellular phenotype
  • abnormal apoptosis   (MGI Ref ID J:87501)
  • aneuploidy   (MGI Ref ID J:87501)
  • decreased cell proliferation
    • in mouse embryonic fibroblasts treated with UV irradiation   (MGI Ref ID J:170976)
  • decreased cellular sensitivity to gamma-irradiation
    • irradiated E13.5 heterozygous embryos showed no evidence of apoptosis in the hypothalamus compared to wildtype and heterozygotes that showed a high number of apoptotic cells   (MGI Ref ID J:95318)
  • decreased cellular sensitivity to ultraviolet irradiation
    • in mouse embryonic fibroblasts   (MGI Ref ID J:170976)
  • increased cell proliferation
    • MEFs initially did not show any significant differences in growth rate but by day 4, grew more rapidly than wildtype or heterozygous MEFs   (MGI Ref ID J:95318)
  • digestive/alimentary phenotype
  • colon polyps
    • 6.7% incidence   (MGI Ref ID J:72391)
  • gastric polyps
    • 3.3% incidence of stomach polyps   (MGI Ref ID J:72391)

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas
  • mortality/aging
  • partial prenatal lethality
    • a slight decrease is seen in the number of females born   (MGI Ref ID J:95316)
  • premature death
    • mean life span is 4.4 months   (MGI Ref ID J:95316)
    • majority of mice (82%) die before 9 months of age, or are euthanized due to occurrence of obvious tumor mass   (MGI Ref ID J:132597)
    • animals die by about 26 weeks   (MGI Ref ID J:88120)
  • nervous system phenotype
  • abnormal neuron differentiation
    • GNPs from mutants show ~50% levels of proliferation compared to Cdkn2c, Trp53-double null cells after 3 days in culture and levels of cells incorporating BrdU are still less in single mutants in tests where cells are stimulated with Shh after culture   (MGI Ref ID J:102702)
  • tumorigenesis
  • increased tumor incidence
    • 32% have multiple tumors   (MGI Ref ID J:95316)
    • increased T cell derived lymphoma incidence
      • 66% of homozygotes display hematological malignancies, primarily T cell lymphomas   (MGI Ref ID J:95316)
      • mice start to develop T cell malignancies at 14-16 weeks   (MGI Ref ID J:88120)
    • increased hemangiosarcoma incidence
      • the incidence of hemangiosarcomas is 32% compared to 62% in Trp53tm1Tyj/Trp53tm2.1Tyj mice   (MGI Ref ID J:95316)
    • increased medulloblastoma incidence
      • 13/19 (68%) of animals receiving 4 Gy radiation at P5 or 6 develop cerebellar tumors   (MGI Ref ID J:102702)
  • cellular phenotype
  • abnormal cell cycle checkpoint function
    • gamma-irradiation fails to produce an increase in the relative number of cells in G1 compared to S phase   (MGI Ref ID J:77907)
    • mouse embryonic fibroblasts exposed to radiation fail to arrest at the G1/S transition unlike similarly treated wild-type cells   (MGI Ref ID J:126920)
  • abnormal neuron differentiation
    • GNPs from mutants show ~50% levels of proliferation compared to Cdkn2c, Trp53-double null cells after 3 days in culture and levels of cells incorporating BrdU are still less in single mutants in tests where cells are stimulated with Shh after culture   (MGI Ref ID J:102702)
  • decreased T cell apoptosis
    • thymocytes are essentially resistant to Trp53-mediated apoptosis   (MGI Ref ID J:109354)
    • decreased thymocyte apoptosis
      • rare following exposure to ionizing radiation   (MGI Ref ID J:126920)
      • in response to irradiation   (MGI Ref ID J:158953)
      • in irradiated thymocytes   (MGI Ref ID J:195018)
  • decreased cellular sensitivity to ultraviolet irradiation
    • reduced sensitivity to UV-induced cell death in MEFs compared to wild-type cells   (MGI Ref ID J:77907)
  • decreased splenocyte apoptosis
    • in irradiated spleen cells   (MGI Ref ID J:195018)
  • increased cell proliferation
  • polyploidy
    • after irradiation with UVC light, MEFs from null mice show higher levels of polyploidy than Trp53tm2Xu homozygotes   (MGI Ref ID J:109354)
  • immune system phenotype
  • decreased T cell apoptosis
    • thymocytes are essentially resistant to Trp53-mediated apoptosis   (MGI Ref ID J:109354)
    • decreased thymocyte apoptosis
      • rare following exposure to ionizing radiation   (MGI Ref ID J:126920)
      • in response to irradiation   (MGI Ref ID J:158953)
      • in irradiated thymocytes   (MGI Ref ID J:195018)
  • decreased splenocyte apoptosis
    • in irradiated spleen cells   (MGI Ref ID J:195018)
  • cardiovascular system phenotype
  • abnormal cardiovascular system physiology
    • better systolic function than control   (MGI Ref ID J:120332)
  • cardiac hypertrophy
    • increased hypertrophy as a result of transverse aortic restriction   (MGI Ref ID J:120332)
  • increased angiogenesis
    • increased number of microvessels form 2 weeks after transverse aortic constriction   (MGI Ref ID J:120332)
  • hematopoietic system phenotype
  • decreased T cell apoptosis
    • thymocytes are essentially resistant to Trp53-mediated apoptosis   (MGI Ref ID J:109354)
    • decreased thymocyte apoptosis
      • rare following exposure to ionizing radiation   (MGI Ref ID J:126920)
      • in response to irradiation   (MGI Ref ID J:158953)
      • in irradiated thymocytes   (MGI Ref ID J:195018)
  • decreased splenocyte apoptosis
    • in irradiated spleen cells   (MGI Ref ID J:195018)
  • endocrine/exocrine gland phenotype
  • decreased thymocyte apoptosis
    • rare following exposure to ionizing radiation   (MGI Ref ID J:126920)
    • in response to irradiation   (MGI Ref ID J:158953)
    • in irradiated thymocytes   (MGI Ref ID J:195018)

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas * BALB/c
  • cellular phenotype
  • increased cellular sensitivity to ionizing radiation
    • at P10, pattern and extent of oocyte loss in ovaries of mutants after exposure to 0.45 Gy radiation on P5 is similar to wild-type and much more sever than Trp63tm2Fmc mutants   (MGI Ref ID J:116176)

Trp53tm1Tyj/Trp53tm1Tyj

        129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
  • mortality/aging
  • premature death
    • mice become moribund from lymphoma involving various tissues within >30 weeks; mice with aggressive lymphoma have a mean survival time of 18 weeks   (MGI Ref ID J:102483)
  • tumorigenesis
  • increased lymphoma incidence
    • mice develop lymphomas   (MGI Ref ID J:102483)
  • increased teratoma incidence
    • median survival time of mice with teratomas is 7 weeks   (MGI Ref ID J:102483)
    • no mice living beyond median survival age show extratesticular teratomas   (MGI Ref ID J:102483)
    • increased testicular teratoma incidence   (MGI Ref ID J:102483)
  • digestive/alimentary phenotype
  • intestinal ulcer
    • after 7 days of dextran sodium sulfate treatment, mice develop large ulcers in the colon   (MGI Ref ID J:102483)
  • growth/size/body phenotype
  • weight loss
    • with DSS treatment, double mutants have an average weight of 14% of body weight   (MGI Ref ID J:102483)

Trp53tm1Tyj/Trp53tm1Tyj

        129-Trp53tm1Tyj/J
  • cardiovascular system phenotype
  • abnormal retinal vasculature morphology
    • abnormally dilated peripheral retinal blood vessels, with some mice exhibiting thin blood vessels extending from the optic nerve head toward the lens, but few reach the lens surface   (MGI Ref ID J:55873)
  • vision/eye phenotype
  • abnormal retinal vasculature morphology
    • abnormally dilated peripheral retinal blood vessels, with some mice exhibiting thin blood vessels extending from the optic nerve head toward the lens, but few reach the lens surface   (MGI Ref ID J:55873)

Trp53tm1Tyj/Trp53tm1Tyj

        B6.129S2-Trp53tm1Tyj/J
  • cardiovascular system phenotype
  • abnormal retinal vasculature morphology
    • abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes   (MGI Ref ID J:55873)
    • abnormally dilated peripheral retinal blood vessels   (MGI Ref ID J:55873)
  • vision/eye phenotype
  • abnormal posterior eye segment morphology
    • on the C57BL/6J background aberrant ocular phenotypes are observed as early as 14 days of age   (MGI Ref ID J:55873)
    • abnormal ocular fundus morphology
      • pigmented or nonpigmented fibrous retrolental tissue is commonly found in homozygotes on the C57BL/6J background   (MGI Ref ID J:55873)
      • abnormal retina morphology
        • retinal folds are found in some homozygotes on the C57BL/6J background   (MGI Ref ID J:55873)
        • abnormal retinal vasculature morphology
          • abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes   (MGI Ref ID J:55873)
          • abnormally dilated peripheral retinal blood vessels   (MGI Ref ID J:55873)
    • abnormal optic nerve morphology
      • the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds   (MGI Ref ID J:55873)
      • optic nerve degeneration
        • degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background   (MGI Ref ID J:55873)
      • optic nerve hypoplasia
        • bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background   (MGI Ref ID J:55873)
    • opacity of vitreous body
      • fine snowflake-like vitreal opacities can be found on the C57BL/6J background by 21 days of age and may result from the accumulation of fibrous and vascular debris in the vitreous   (MGI Ref ID J:55873)
  • nervous system phenotype
  • abnormal optic nerve morphology
    • the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds   (MGI Ref ID J:55873)
    • optic nerve degeneration
      • degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background   (MGI Ref ID J:55873)
    • optic nerve hypoplasia
      • bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background   (MGI Ref ID J:55873)

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas * FVB/N
  • cellular phenotype
  • decreased cellular sensitivity to ionizing radiation
    • following ionizing radiation treatment, hair follicles do not exhibit apoptosis unlike in similarly treated wild-type mice   (MGI Ref ID J:114161)
    • following ionizing radiation treatment, arrested cell growth in the epidermis is partially abrogated compared to in similarly treated wild-type mice   (MGI Ref ID J:114161)
  • integument phenotype
  • decreased sensitivity to skin irradiation
    • following ionizing radiation treatment, arrested cell growth in the epidermis is partially abrogated compared to in similarly treated wild-type mice   (MGI Ref ID J:114161)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Trp53tm1Tyj related

Apoptosis Research
Endogenous Regulators

Cancer Research
Increased Tumor Incidence
      Lymphomas
      Other Tissues/Organs
      Other Tissues/Organs: osteosarcoma
Toxicology
Tumor Suppressor Genes

Immunology, Inflammation and Autoimmunity Research
Intracellular Signaling Molecules

Research Tools
Toxicology Research
      B and T cell deficiency, xenograft transplant host
      drug/compound testing

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Trp53tm1Tyj
Allele Name targeted mutation 1, Tyler Jacks
Allele Type Targeted (Null/Knockout)
Common Name(s) Trp53-; Trp53KO; p53-; p53delta; p53null; p53KO;
Mutation Made ByDr. Tyler Jacks,   Massachusetts Institute of Technology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Trp53, transformation related protein 53
Chromosome 11
Gene Common Name(s) BCC7; LFS1; P53; p44;
General Note This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in amouse model, resulting in a similar gene product (J:27363).
Phenotypic Similarity to Human Syndrome: Glioblastoma Multiforme (J:149662)
Phenotypic Similarity to Human Syndrome: Astrocytoma (J:64364 and J:134611)
Phenotypic Similarity to Human Syndrome: activated B-cell diffuse large-cell lymphoma in mice hemizygous for Tg(Ly6e-MALT1)#Isg and homozygous for this allele (ABC-DLBCL, J:185590)
Molecular Note A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6. [MGI Ref ID J:17728]

Genotyping

Genotyping Information

Genotyping Protocols

Trp53tm1Tyj, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Jacks T; Remington L; Williams BO; Schmitt EM; Halachmi S; Bronson RT; Weinberg RA. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4(1):1-7. [PubMed: 7922305]  [MGI Ref ID J:17728]

Additional References

Cheng J; Huang H; Pak J; Shapiro E; Sun TT; Cordon-Cardo C; Waldman FM; Wu XR. 2003. Allelic Loss of p53 Gene Is Associated with Genesis and Maintenance, but not Invasion, of Mouse Carcinoma in Situ of the Bladder. Cancer Res 63(1):179-85. [PubMed: 12517796]  [MGI Ref ID J:81056]

Lowe SW; Schmitt EM; Smith SW; Osborne BA; Jacks T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes [see comments] Nature 362(6423):847-9. [PubMed: 8479522]  [MGI Ref ID J:16022]

Sah VP; Attardi LD; Mulligan GJ; Williams BO; Bronson RT; Jacks T. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10(2):175-80. [PubMed: 7663512]  [MGI Ref ID J:23197]

Trp53tm1Tyj related

Aarabi S; Bhatt KA; Shi Y; Paterno J; Chang EI; Loh SA; Holmes JW; Longaker MT; Yee H; Gurtner GC. 2007. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 21(12):3250-61. [PubMed: 17504973]  [MGI Ref ID J:143834]

Ablamunits V; Cohen Y; Brazee IB; Gaetz HP; Vinson C; Klebanov S. 2006. Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice. Cancer Res 66(17):8897-902. [PubMed: 16951207]  [MGI Ref ID J:112412]

Aggarwal P; Lessie MD; Lin DI; Pontano L; Gladden AB; Nuskey B; Goradia A; Wasik MA; Klein-Szanto AJ; Rustgi AK; Bassing CH; Diehl JA. 2007. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev 21(22):2908-22. [PubMed: 18006686]  [MGI Ref ID J:127316]

Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747]  [MGI Ref ID J:112935]

Ahkter S; Richie CT; Zhang N; Behringer RR; Zhu C; Legerski RJ. 2005. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol 25(22):10071-8. [PubMed: 16260620]  [MGI Ref ID J:102381]

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Zeng Q; Oakley B. 1999. p53 and Bax: putative death factors in taste cell turnover. J Comp Neurol 413(1):168-80. [PubMed: 10464378]  [MGI Ref ID J:57477]

Zhang J; Cho SJ; Shu L; Yan W; Guerrero T; Kent M; Skorupski K; Chen H; Chen X. 2011. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev 25(14):1528-43. [PubMed: 21764855]  [MGI Ref ID J:174192]

Zhang J; Schweers B; Dyer MA. 2004. The first knockout mouse model of retinoblastoma. Cell Cycle 3(7):952-9. [PubMed: 15190215]  [MGI Ref ID J:103618]

Zhang L; Anglesio MS; O'sullivan M; Zhang F; Yang G; Sarao R; Nghiem MP; Cronin S; Hara H; Melnyk N; Li L; Wada T; Liu PP; Farrar J; Arceci RJ; Sorensen PH; Penninger JM. 2007. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med 13(9):1060-1069. [PubMed: 17694067]  [MGI Ref ID J:125183]

Zhang L; Reynolds TL; Shan X; Desiderio S. 2011. Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34(2):163-74. [PubMed: 21349429]  [MGI Ref ID J:168974]

Zhang M; Behbod F; Atkinson RL; Landis MD; Kittrell F; Edwards D; Medina D; Tsimelzon A; Hilsenbeck S; Green JE; Michalowska AM; Rosen JM. 2008. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68(12):4674-82. [PubMed: 18559513]  [MGI Ref ID J:138898]

Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G. 2012. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J Pathol 228(3):416-28. [PubMed: 22821713]  [MGI Ref ID J:188490]

Zhang S; Zheng M; Kibe R; Huang Y; Marrero L; Warren S; Zieske AW; Iwakuma T; Kolls JK; Cui Y. 2011. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J 25(7):2387-98. [PubMed: 21471252]  [MGI Ref ID J:174321]

Zhang X; Podsypanina K; Huang S; Mohsin SK; Chamness GC; Hatsell S; Cowin P; Schiff R; Li Y. 2005. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene 24(26):4220-31. [PubMed: 15824740]  [MGI Ref ID J:99546]

Zhao F; Obermann S; von Wasielewski R; Haile L; Manns MP; Korangy F; Greten TF. 2009. Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. Immunology 128(1):141-9. [PubMed: 19689743]  [MGI Ref ID J:162293]

Zheng S; El-Naggar AK; Kim ES; Kurie JM; Lozano G. 2007. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 26(48):6896-904. [PubMed: 17486075]  [MGI Ref ID J:129627]

Zhou S; Gu L; He J; Zhang H; Zhou M. 2011. MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia. Mol Cell Biol 31(24):4928-37. [PubMed: 21986500]  [MGI Ref ID J:178311]

Zhu F; Dolle ME; Berton TR; Kuiper RV; Capps C; Espejo A; McArthur MJ; Bedford MT; van Steeg H; de Vries A; Johnson DG. 2010. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res 70(14):5851-9. [PubMed: 20587514]  [MGI Ref ID J:162466]

Zhu M; Weiss RS. 2007. Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell 18(3):1044-55. [PubMed: 17215515]  [MGI Ref ID J:123894]

Zhu Y; Guignard F; Zhao D; Liu L; Burns DK; Mason RP; Messing A; Parada LF. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8(2):119-30. [PubMed: 16098465]  [MGI Ref ID J:101868]

Zhuang J; Wang PY; Huang X; Chen X; Kang JG; Hwang PM. 2013. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A 110(43):17356-61. [PubMed: 24101517]  [MGI Ref ID J:201969]

Zindy F; Nilsson LM; Nguyen L; Meunier C; Smeyne RJ; Rehg JE; Eberhart C; Sherr CJ; Roussel MF. 2003. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 63(17):5420-7. [PubMed: 14500377]  [MGI Ref ID J:85515]

Zou X; Cong F; Coutts M; Cattoretti G; Goff SP; Calame K. 2000. p53 deficiency increases transformation by v-Abl and rescues the ability of a C-terminally truncated v-Abl mutant To induce pre-B lymphoma In vivo Mol Cell Biol 20(2):628-33. [PubMed: 10611241]  [MGI Ref ID J:59574]

Zou Y; Niu W; Qin S; Downes M; Burns DK; Zhang CL. 2012. The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol 32(23):4811-20. [PubMed: 23028043]  [MGI Ref ID J:192734]

Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76(4):1649-56. [PubMed: 18268032]  [MGI Ref ID J:133523]

Zwolinska AK; Heagle Whiting A; Beekman C; Sedivy JM; Marine JC. 2012. Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency. Oncogene 31(28):3311-21. [PubMed: 22081066]  [MGI Ref ID J:186119]

de Stanchina E; McCurrach ME; Zindy F; Shieh SY; Ferbeyre G; Samuelson AV; Prives C; Roussel MF; Sherr CJ; Lowe SW. 1998. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 12(15):2434-42. [PubMed: 9694807]  [MGI Ref ID J:115135]

ter Brugge PJ; Ta VB; de Bruijn MJ; Keijzers G; Maas A; van Gent DC; Hendriks RW. 2009. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 114(1):119-27. [PubMed: 19332766]  [MGI Ref ID J:150315]

van Kesteren PC; Beems RB; Luijten M; Robinson J; de Vries A; van Steeg H. 2009. DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance? Carcinogenesis 30(3):538-43. [PubMed: 19136475]  [MGI Ref ID J:146183]

van Kesteren PC; Zwart PE; Pennings JL; Gottschalk WH; Kleinjans JC; van Delft JH; van Steeg H; Luijten M. 2011. Deregulation of Cancer-Related Pathways in Primary Hepatocytes Derived from DNA Repair-Deficient Xpa-/-p53+/- Mice upon Exposure to Benzo[a]pyrene. Toxicol Sci 123(1):123-32. [PubMed: 21715664]  [MGI Ref ID J:175079]

van Kranen HJ; Westerman A; Berg RJ; Kram N; van Kreijl CF; Wester PW; de Gruijl FR. 2005. Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice. Mutat Res 571(1-2):81-90. [PubMed: 15748640]  [MGI Ref ID J:96767]

van Kreijl CF; McAnulty PA; Beems RB; Vynckier A; van Steeg H; Fransson-Steen R; Alden CL; Forster R; van der Laan JW; Vandenberghe J. 2001. Xpa and Xpa/p53+/- knockout mice: overview of available data. Toxicol Pathol 29 Suppl:117-27. [PubMed: 11695547]  [MGI Ref ID J:73024]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Notice to customers in Canada.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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