Strain Name: |
STOCK Myo7ash1-7J/J |
|---|---|
Stock Number: |
002919 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Myo7a; Myo7ash1-7J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Chemically Induced Mutation Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Stock Species laboratory mouse Generation F30N1F14p (10-APR-05) Appearance
black, tremors
Related Genotype: a/a Myo7ash1-7J/Myo7ash1-7J
black, unaffected
Related Genotype: a/a Myo7ash1-7J/+ or a/a ?/+Strain Description
Myo7ash1-7J homozygotes exhibit circling behavior, a slight head tilt and side-to-side head bob. They develop progressive hearing loss, becoming totally deaf by 60 days of age. Heterozygotes are normal. (Samples et al., 2000). Mutations of the human ortholog of Myo7a, MYO7A, have been characterized in pedigrees of patients having Usher syndrome type 1 (USH1), an autosomal recessive disorder characterized by profound deafness, vestibular dysfunction and progressive retinitis pigmentosa (Weil et al., 1995; Weston et al., 1996; Adato et al., 1997; Levy et al., 1997; Liu et al., 1998; Espinos et al., 1998; Cuevas et al., 1998, 1999; Janecke et al., 1999). MYO7A mutations have also been identified in patients with autosomal dominant non-syndromic deafness (Liu et al., 1997) and autosomal recessive isolated deafness (Liu et al., 1997; Weil et al., 1997).Strain Development
A male B10.D2-H2dm1/Eg treated with 30 mg of 1-ethyl-1-nitrosourea (ENU) was bred with a female C57BL/6J-H2bm3/Eg and the offspring were sibling mated. A circling phenotype was identified in subsequent progeny that were homozygous for the H2bm3 allele. This mutation was shown to be an allele of Myo7a and was backcrossed once to C57BL/6J before being subsequently maintained by sibling mating.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Myo7ash1-7J | ||
|---|---|---|---|
| Allele Name | shaker 1, 7 Jackson | ||
| Strain of Origin | B10.D2-H2dm1/Eg | ||
| Gene Symbol and Name | Myo7a, myosin VIIa | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | DFNA11; DFNB2; MYOVIIA; MYU7A; Myo7; NSRD2; USH1B; myosin VII; neuroscience mutagenesis facility, 371; nmf371; sh-1; sh1; shaker 1; | ||
| Molecular Note | This ENU-induced mutation was shown to be an allele of Myo7a. | ||
Control Information
| Allele | Control | |
|---|---|---|
| Myo7ash1-7J | Untyped from the colony | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Myo7a
003184 B6.Cg-Myo7ash1-8J/J 005468 C57BL/6J-Myo7ash1-11J/J 000619 FS/EiJ 000271 SH1/LeJ View Strains carrying other alleles of Myo7a (4 strains)
Research Applications
This mouse can be used to support research in many areas including:Myo7ash1-7J related
Mouse/Human Gene Homologs
Usher syndrome, type IB (deafness, neurosensory, autosomal recessive, 2, and deafness, autosomal dominant nonsyndromic sensorineural, 11)
Neurobiology Research
Tremor Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | STOCK Myo7ash1-7J/J |
| Stock Number: | 002919 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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