Strain Name:

B6.D2N-Ahrd/J

Stock Number:

002921

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Availability:

Cryopreserved - Ready for recovery

Mice congenic for aryl hydrocarbon receptor (Ahr) alleles are useful in metabolic research and drug toxicity studies. Sensitivity to carcinogens often differs between the congenic and the recipient strain.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain DBA/2N
 
Donating InvestigatorDr. Alan Poland,  

Appearance
black
Related Genotype: a/a

Description
In this congenic strain, the DBA/2-derived d variant of the aryl hydrocarbon receptor gene (Ahr) was introgressed onto the C57BL/6N background. Ahrd occurs naturally in DBA/2, AKR, 129, SWR, RF, and NZB strains. Mice congenic for Ahr alleles are useful in metabolic research and drug toxicity studies. Sensitivity to carcinogens often differs between the congenic and the recipient strain.

Development
The Ahrd allele was backcrossed from DBA/2N onto C57BL/6N via a backcross-intercross breeding scheme by Dr. Daniel Nebert. At generation N13 this congenic was then transferred to Dr Alan Poland et al., who then backcrossed the Ahrd allele onto C57BL/6J, again via a backcross-intercross breeding scheme, and homozygotes at or beyond generation N17 were sent to The Jackson Laboratory in 1997 and maintained by sibling intercross. The d allele found in DBA/2 differs from the b-1 allele found in C57BL by 10 nucleotides, five of which represent amino acid changes.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ahrd allele
000690   129P3/J
000648   AKR/J
008599   B6.Cg-Del(9Cyp1a2-Cyp1a1)1Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
000652   BDP/J
000928   CAST/EiJ
000671   DBA/2J
000674   I/LnJ
000675   LG/J
000676   LP/J
000684   NZB/BlNJ
000726   RBF/DnJ
000682   RF/J
000686   SJL/J
000688   ST/bJ
000689   SWR/J
000693   WC/ReJ KitlSl/J
000933   YBR/EiJ
View Strains carrying   Ahrd     (17 strains)

Strains carrying other alleles of Ahr
000645   A/HeJ
000646   A/J
002920   B6(D2N).Spretus-Ahrb-3/J
002831   B6.129-Ahrtm1Bra/J
000130   B6.C-H17c/(HW14)ByJ
000136   B6.C-H34c/(HW22)ByJ
000370   B6.C-H38c/(HW119)ByJ
002727   B6;129-Ahrtm1Bra/J
001026   BALB/cByJ
000653   BUB/BnJ
000659   C3H/HeJ
000663   C57BL/6By
001139   C57BL/6ByJ
000664   C57BL/6J
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000926   CAROLI/EiJ
000656   CBA/J
000657   CE/J
000351   CXB1/ByJ
000352   CXB2/ByJ
000353   CXB3/ByJ
000354   CXB4/ByJ
000355   CXB5/ByJ
000356   CXB6/ByJ
000357   CXB7/ByJ
002937   D2.B6-Ahrb-1/J
000673   HRS/J
000677   MA/MyJ
000550   MOLF/EiJ
000679   P/J
000930   PERA/EiJ
000644   SEA/GnJ
000280   SF/CamEiJ
001146   SPRET/EiJ
006203   STOCK Ahrtm3.1Bra/J
View Strains carrying other alleles of Ahr     (38 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ahrd/Ahrd

        B6.D2-Ahrd
  • mortality/aging
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • unlike C57BL/6-Ahrb-1 neonates, mice are not susceptible to lethality induced by in utero exposure to cHBB   (MGI Ref ID J:113285)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • following exposure to cHBB in utero, neonates exhibit a lesser increase in volume density of hemopoietic islands in the liver compared to in C57BL/6-Ahrb-1 neonates   (MGI Ref ID J:113285)
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • unlike C57BL/6-Ahrb-1 neonates, mice are not susceptible to lethality induced by in utero exposure to cHBB   (MGI Ref ID J:113285)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ahrd/Ahrd

        DBA/2J
  • mortality/aging
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • mice are more resistant to the teratogenic effects of TCDD than Ahrb-1 homozygotes with only 30% of mice exhibiting altered palate development compared to 100% of Ahrb-1 homozygotes   (MGI Ref ID J:132380)
    • mice from mothers treated with TCDD exhibit a similar incidence of hydronephrosis as Ahrb-1 homozygotes but at a reduced severity   (MGI Ref ID J:132380)
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)

Ahrd/Ahrd

        AKR
  • mortality/aging
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects   (MGI Ref ID J:26440)

Ahrd/Ahrd

        involves: 129S1/SvImJ * C57BL/6J
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized   (MGI Ref ID J:113356)
    • however, maternal genotype of Ahrd/Ahrd improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype   (MGI Ref ID J:113356)
  • homeostasis/metabolism phenotype
  • increased physiological sensitivity to xenobiotic
    • mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized   (MGI Ref ID J:113356)
    • however, maternal genotype of Ahrd/Ahrd improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype   (MGI Ref ID J:113356)
    • increased incidence of tumors by chemical induction
      • offspring exposed to DBP in utero exhibit an increased susceptibility to developing lymphomas   (MGI Ref ID J:113356)
      • offspring exposed to DBP in utero exhibit increased rates of lung cancer (though lower than in offspring of Ahrd/Ahrd dams) and liver tumors in male mice   (MGI Ref ID J:113356)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized   (MGI Ref ID J:113356)
    • however, maternal genotype of Ahrd/Ahrd improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype   (MGI Ref ID J:113356)
  • tumorigenesis
  • increased incidence of tumors by chemical induction
    • offspring exposed to DBP in utero exhibit an increased susceptibility to developing lymphomas   (MGI Ref ID J:113356)
    • offspring exposed to DBP in utero exhibit increased rates of lung cancer (though lower than in offspring of Ahrd/Ahrd dams) and liver tumors in male mice   (MGI Ref ID J:113356)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ahrd related

Metabolism Research

Research Tools
Toxicology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ahrd
Allele Name d variant
Allele Type Not Applicable
Common Name(s) Ahd; Ahk; AhRd; Ahhn; ah; in;
Gene Symbol and Name Ahr, aryl-hydrocarbon receptor
Chromosome 12
Gene Common Name(s) Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
General Note Compared with Ahrd/Ahrd mice, Ahrb/Ahrb individuals have a high inflammatory response to cutaneous application of dimethylbenzanthracene; a high susceptibility to methylcholanthrene- and benzopyrene-induced subcutaneous sarcomas and methylcholanthrene-induced lung tumors; an increased resistance to zoxazolamine-induced paralysis, lindane toxicity, and benzo[a]pyrene-induced aplastic anemia and leukemia; a high susceptibility to acetaminophen-induced hepatic necrosis and cataract formation; and an increased susceptibility to polycyclic hydrocarbon-induced birth defects, stillbirths, resorptions, decreased body weight, ovarian primordial oocyte depletion, and spermatozoal aberrations (J:5822). The Ahrballele is associated with increases in numerous metabolites of chemical carcinogens binding to DNA nucleotides (J:12156). The effectiveness of several mutagens for Salmonella in vitro is enhanced by presence of a liver fraction from Ahrb/Ahrb> mice treated with polycyclic hydrocarbons, but not from similarly treated Ahrd/Ahr mice (J:5564). In contrast, oral doses of benzopyrene cause a high rate of leukemia in Ahrd/Ahrd but not in Ahrd/Ahrd mice, probably because the carcinogenic metabolites produced in responsive Ahrb/Ahrd mice are rapidly degraded in the intestine and excreted in the feces (J:6074).

Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains

Molecular Note This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. [MGI Ref ID J:15153] [MGI Ref ID J:17460] [MGI Ref ID J:22144]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080]  [MGI Ref ID J:22144]

Additional References

Ahrd related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. [PubMed: 4123113]  [MGI Ref ID J:84312]

Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. [PubMed: 1030186]  [MGI Ref ID J:12156]

Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. [PubMed: 18848954]  [MGI Ref ID J:143604]

Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. [PubMed: 8148872]  [MGI Ref ID J:17460]

Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. [PubMed: 16291824]  [MGI Ref ID J:113285]

Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. [PubMed: 808546]  [MGI Ref ID J:5564]

Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. [PubMed: 4110756]  [MGI Ref ID J:84250]

Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. [PubMed: 4118365]  [MGI Ref ID J:84252]

Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. [PubMed: 1658612]  [MGI Ref ID J:2134]

Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. [PubMed: 22228805]  [MGI Ref ID J:183715]

Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. [PubMed: 679184]  [MGI Ref ID J:84318]

Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. [PubMed: 22982977]  [MGI Ref ID J:192865]

Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. [PubMed: 21270426]  [MGI Ref ID J:173706]

Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A 100(10):5652-7. [PubMed: 12730383]  [MGI Ref ID J:132380]

Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York.  [MGI Ref ID J:30693]

Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. [PubMed: 4716952]  [MGI Ref ID J:84313]

Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134(1):76-89. [PubMed: 4981257]  [MGI Ref ID J:84248]

Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109]  [MGI Ref ID J:5282]

Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. Mol Pharmacol 8(6):651-66. [PubMed: 4118364]  [MGI Ref ID J:84251]

Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol 236(65):107-10. [PubMed: 4502804]  [MGI Ref ID J:84249]

Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus. Biochem Pharmacol 28(1):149-51. [PubMed: 758905]  [MGI Ref ID J:6074]

Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. [PubMed: 7095422]  [MGI Ref ID J:6809]

Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. J Biol Chem 248(1):169-78. [PubMed: 4348203]  [MGI Ref ID J:84311]

Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. [PubMed: 1091656]  [MGI Ref ID J:84317]

Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. [PubMed: 1119809]  [MGI Ref ID J:84316]

Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. Mol Pharmacol 9(5):629-6. [PubMed: 4788156]  [MGI Ref ID J:25852]

Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol 35(6):823-30. [PubMed: 2543914]  [MGI Ref ID J:27899]

Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene Proc Am Assoc Cancer Res 2:335.  [MGI Ref ID J:84245]

Poland A; Bradfield C. 1992. A brief review of the Ah locus. Tohoku J Exp Med 168(2):83-7. [PubMed: 1339107]  [MGI Ref ID J:12546]

Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251(16):4936-46. [PubMed: 956169]  [MGI Ref ID J:84247]

Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093]  [MGI Ref ID J:8895]

Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor. Mol Pharmacol 36(1):121-7. [PubMed: 2546046]  [MGI Ref ID J:126377]

Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. J Biol Chem 249(17):5599-606. [PubMed: 4370044]  [MGI Ref ID J:84314]

Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453(7191):65-71. [PubMed: 18362915]  [MGI Ref ID J:136052]

Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. [PubMed: 4413562]  [MGI Ref ID J:84315]

Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. Cancer Res 27(3):563-7. [PubMed: 6021514]  [MGI Ref ID J:84246]

Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. Cancer Res 29(8):1585-9. [PubMed: 5807232]  [MGI Ref ID J:34134]

Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. [PubMed: 6021513]  [MGI Ref ID J:26440]

Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. [PubMed: 8408082]  [MGI Ref ID J:15153]

Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochem Biophys Res Commun 376(4):775-80. [PubMed: 18814841]  [MGI Ref ID J:141523]

Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol 267(3):209-17. [PubMed: 23337360]  [MGI Ref ID J:193493]

Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207(10):2239-53. [PubMed: 20855496]  [MGI Ref ID J:165803]

Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. [PubMed: 9443932]  [MGI Ref ID J:45850]

Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125(2):345-58. [PubMed: 22086975]  [MGI Ref ID J:183662]

Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver. Toxicol Sci 129(2):372-9. [PubMed: 22696238]  [MGI Ref ID J:188164]

Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci I 10(19):1127-34. [PubMed: 5132702]  [MGI Ref ID J:5244]

Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. [PubMed: 4750810]  [MGI Ref ID J:5387]

Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet 6(2):157-68. [PubMed: 4666754]  [MGI Ref ID J:31977]

Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25:149-93. [PubMed: 405846]  [MGI Ref ID J:5822]

Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 101(47):16677-82. [PubMed: 15545609]  [MGI Ref ID J:94465]

Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'. Toxicol Sci 111(2):238-46. [PubMed: 19474220]  [MGI Ref ID J:154083]

Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis 27(10):2116-23. [PubMed: 16704990]  [MGI Ref ID J:113356]

Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 121(16):3195-204. [PubMed: 23462117]  [MGI Ref ID J:197552]

Health & husbandry

Health & Colony Maintenance Information

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Strains Requiring Specialized Phenotyping.
    At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. We will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We cannot guarantee that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. Because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 25 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Strains Requiring Specialized Phenotyping.
    At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. We will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We cannot guarantee that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. Because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 25 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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