Strain Name: |
CNCr.129P2-Cd40tm1Kik/J |
|---|---|
Stock Number: |
002927 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
CNCr.129P2-Tnfrsf5tm1Kik/J (Changed: 30-SEP-05
) |
|
Cd40 (Changed: 15-DEC-04
) | |
| Genes & Alleles | Cd40; Cd40tm1Kik; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Background Strain BALB/cAnNcr Donor Strain 129P2 via E14-1 ES cell line Donating Investigator Hitoshi Kikutani, Osaka University Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/TyrcStrain Description
Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Cd40tm1Kik | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Hitoshi Kikutani | ||
| Common Name(s) | CD40 Ko; CD40-; CD40KO; Tnfrsf5-; | ||
| Mutation Made By | Hitoshi Kikutani, Osaka University | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14.1 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Cd40, CD40 antigen | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AI326936; Bp50; CDW40; MGC9013; TNFRSF5; Tnfrsf5; expressed sequence AI326936; p50; tumor necrosis factor receptor superfamily, member 5; | ||
| Molecular Note | A neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed. [MGI Ref ID J:25007] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Cd40tm1Kik | 001026 BALB/cByJ | |
| The Jackson Laboratory does not have the BALB/cAnNcr substrain. BALB/cByJ mice(Stock No. 001026) are the most closely related substrain and may be used as a control although we have not tested histocompatibility between the two strains. | ||
| Considerations for Choosing Controls | ||
Genotyping Protocols
Cd40tm1Kik
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Cd40tm1Kik allele
002928 B6.129P2-Cd40tm1Kik/J View Strains carrying Cd40tm1Kik (1 strain)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Cd40tm1Kik related
Cancer Research
Growth Factors/Receptors/Cytokines
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Growth Factors/Receptors/Cytokines
References
Selected Reference(s)
Additional ReferencesKawabe T; Naka T; Yoshida K; Tanaka T; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T; Kikutani H. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1(3):167-78. [PubMed: 7534202] [MGI Ref ID J:25007]
Price and Supply Information
| Strain Name: | CNCr.129P2-Cd40tm1Kik/J |
| Stock Number: | 002927 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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