Strain Name:

CNCr.129P2-Cd40tm1Kik/J

Stock Number:

002927

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names CNCr.129P2-Tnfrsf5tm1Kik/J    (Changed: 30-SEP-05 )
Cd40    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/cAnNcr
Donor Strain 129P2 via E14-1 ES cell line
 
Donating InvestigatorDr. Hitoshi Kikutani,   Osaka University

Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.

Control Information

  Control
   See control note: The Jackson Laboratory does not have the BALB/cAnNcr substrain. BALB/cByJ mice(Stock No. 001026) are the most closely related substrain and may be used as a control although we have not tested histocompatibility between the two strains.
   001026 BALB/cByJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cd40tm1Kik allele
002928   B6.129P2-Cd40tm1Kik/J
View Strains carrying   Cd40tm1Kik     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Immunodeficiency with Hyper-Igm, Type 3; HIGM3   (CD40)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cd40tm1Kik/Cd40tm1Kik

        B6.129P2-Cd40tm1Kik/J
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype
    • normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles   (MGI Ref ID J:75152)
    • decreased platelet aggregation
      • reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion   (MGI Ref ID J:108988)
  • immune system phenotype
  • abnormal dendritic cell physiology
    • impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7   (MGI Ref ID J:86998)
    • impaired priming of IFN-gamma producing T cells   (MGI Ref ID J:86998)
  • increased susceptibility to bacterial infection
    • increased susceptibility to aerosol Mycobacterium tuberculosis infection   (MGI Ref ID J:86998)
    • increased bacterial loads in lung and spleen   (MGI Ref ID J:86998)
    • 40% of infected mice moribund 3 - 4 weeks postinfection   (MGI Ref ID J:86998)
  • homeostasis/metabolism phenotype
  • decreased cerebral infarction size
    • significantly reduced infarct volumes   (MGI Ref ID J:108988)
  • decreased platelet aggregation
    • reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion   (MGI Ref ID J:108988)
  • nervous system phenotype
  • decreased cerebral infarction size
    • significantly reduced infarct volumes   (MGI Ref ID J:108988)
  • skeleton phenotype
  • decreased bone mineral density
    • significantly reduced   (MGI Ref ID J:145330)
  • decreased compact bone mass
    • significantly reduced   (MGI Ref ID J:145330)
  • decreased trabecular bone mass
    • significantly reduced   (MGI Ref ID J:145330)

Cd40tm1Kik/Cd40tm1Kik

        involves: 129P2/OlaHsd * C57BL/6
  • hematopoietic system phenotype
  • absent spleen germinal center
    • failed to form   (MGI Ref ID J:25007)
  • decreased immunoglobulin level
    • reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
    • response to thymus-independent (TI) antigens was in tact   (MGI Ref ID J:25007)
    • decreased IgA level
      • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
    • decreased IgE level
      • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
    • decreased IgG1 level
      • reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • decreased serum concentrations of IgG1 in unimmunized mice   (MGI Ref ID J:25007)
    • decreased IgG2a level
      • reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • decreased serum concentrations of IgG2a in unimmunized mice   (MGI Ref ID J:25007)
    • decreased IgG2b level
      • reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • decreased serum concentrations of IgG2b in unimmunized mice   (MGI Ref ID J:25007)
    • decreased IgG3 level
      • reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • IgG3 serum concentrations in unimmunized mice are not decreased   (MGI Ref ID J:25007)
  • decreased neutrophil cell number
    • in non-SPF facilities compared to wild-type controls   (MGI Ref ID J:25007)
  • immune system phenotype
  • *normal* immune system phenotype
    • normal numbers and ratios of T and B cells   (MGI Ref ID J:25007)
    • abnormal humoral immune response   (MGI Ref ID J:25007)
      • decreased immunoglobulin level
        • reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • response to thymus-independent (TI) antigens was in tact   (MGI Ref ID J:25007)
        • decreased IgA level
          • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
        • decreased IgE level
          • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
        • decreased IgG1 level
          • reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • decreased serum concentrations of IgG1 in unimmunized mice   (MGI Ref ID J:25007)
        • decreased IgG2a level
          • reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • decreased serum concentrations of IgG2a in unimmunized mice   (MGI Ref ID J:25007)
        • decreased IgG2b level
          • reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • decreased serum concentrations of IgG2b in unimmunized mice   (MGI Ref ID J:25007)
        • decreased IgG3 level
          • reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
          • IgG3 serum concentrations in unimmunized mice are not decreased   (MGI Ref ID J:25007)
    • absent spleen germinal center
      • failed to form   (MGI Ref ID J:25007)
    • decreased neutrophil cell number
      • in non-SPF facilities compared to wild-type controls   (MGI Ref ID J:25007)
    • decreased susceptibility to type II hypersensitivity reaction
      • in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis   (MGI Ref ID J:61673)
      • deposition of IgG and complement in glomeruli not observed   (MGI Ref ID J:61673)
      • glomeruli almost normal   (MGI Ref ID J:61673)
      • fibrin deposition in glomeruli not observed   (MGI Ref ID J:61673)
      • failure to induce proteinuria   (MGI Ref ID J:61673)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Sensorineural Research
Nociception

Cd40tm1Kik related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cd40tm1Kik
Allele Name targeted mutation 1, Hitoshi Kikutani
Allele Type Targeted (Null/Knockout)
Common Name(s) CD40 Ko; CD40-; CD40KO; Tnfrsf5-; Tnfrsf5tm1Kik;
Mutation Made ByDr. Hitoshi Kikutani,   Osaka University
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Cd40, CD40 antigen
Chromosome 2
Gene Common Name(s) AI326936; Bp50; CDW40; TNFRSF5; Tnfrsf5; expressed sequence AI326936; p50; tumor necrosis factor receptor superfamily, member 5;
Molecular Note A neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed. [MGI Ref ID J:25007]

Genotyping

Genotyping Information

Genotyping Protocols

Cd40tm1Kik, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Kawabe T; Naka T; Yoshida K; Tanaka T; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T; Kikutani H. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1(3):167-78. [PubMed: 7534202]  [MGI Ref ID J:25007]

Additional References

Montfort MJ; Bouwer HG; Wagner CR; Hinrichs DJ. 2004. The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40. J Immunol 173(6):4084-90. [PubMed: 15356158]  [MGI Ref ID J:92749]

Ruedl C; Bachmann MF; Kopf M. 2000. The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur J Immunol 30(7):2056-64. [PubMed: 10940895]  [MGI Ref ID J:63646]

Cd40tm1Kik related

Aiba Y; Yamazaki T; Okada T; Gotoh K; Sanjo H; Ogata M; Kurosaki T. 2006. BANK negatively regulates Akt activation and subsequent B cell responses. Immunity 24(3):259-68. [PubMed: 16546095]  [MGI Ref ID J:113321]

Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340-8. [PubMed: 16081804]  [MGI Ref ID J:107507]

Akiyama T; Shimo Y; Yanai H; Qin J; Ohshima D; Maruyama Y; Asaumi Y; Kitazawa J; Takayanagi H; Penninger JM; Matsumoto M; Nitta T; Takahama Y; Inoue J. 2008. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29(3):423-37. [PubMed: 18799149]  [MGI Ref ID J:139649]

Anderson BE; McNiff JM; Jain D; Blazar BR; Shlomchik WD; Shlomchik MJ. 2005. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105(5):2227-34. [PubMed: 15522961]  [MGI Ref ID J:98140]

Andre P; Prasad KS; Denis CV; He M; Papalia JM; Hynes RO; Phillips DR; Wagner DD. 2002. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med 8(3):247-52. [PubMed: 11875495]  [MGI Ref ID J:75152]

Arcipowski KM; Bishop GA. 2012. TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1. J Immunol 189(11):5165-70. [PubMed: 23109728]  [MGI Ref ID J:190665]

Arcipowski KM; Stunz LL; Bishop GA. 2014. TRAF6 is a critical regulator of LMP1 functions in vivo. Int Immunol 26(3):149-58. [PubMed: 24170780]  [MGI Ref ID J:207011]

Bachmann MF; Schwarz K; Wolint P; Meijerink E; Martin S; Manolova V; Oxenius A. 2004. Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells. J Immunol 173(4):2217-21. [PubMed: 15294930]  [MGI Ref ID J:92734]

Bachmann MF; Wong BR; Josien R; Steinman RM; Oxenius A; Choi Y. 1999. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med 189(7):1025-31. [PubMed: 10190893]  [MGI Ref ID J:111460]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Bedenikovic G; Crouse J; Oxenius A. 2014. T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling. Eur J Immunol 44(1):115-26. [PubMed: 24108445]  [MGI Ref ID J:208658]

Bergthorsdottir S; Gallagher A; Jainandunsing S; Cockayne D; Sutton J; Leanderson T; Gray D. 2001. Signals that initiate somatic hypermutation of B cells in vitro. J Immunol 166(4):2228-34. [PubMed: 11160276]  [MGI Ref ID J:127146]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Bhadra R; Gigley JP; Khan IA. 2011. Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. J Immunol 187(9):4421-5. [PubMed: 21949017]  [MGI Ref ID J:179445]

Bielinska AU; Makidon PE; Janczak KW; Blanco LP; Swanson B; Smith DM; Pham T; Szabo Z; Kukowska-Latallo JF; Baker JR Jr. 2014. Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant. J Immunol 192(6):2722-33. [PubMed: 24532579]  [MGI Ref ID J:209908]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Bourgeois C; Rocha B; Tanchot C. 2002. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297(5589):2060-3. [PubMed: 12242444]  [MGI Ref ID J:127835]

Buhlmann JE; Elkin SK; Sharpe AH. 2003. A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8. [PubMed: 12759417]  [MGI Ref ID J:83454]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burocchi A; Pittoni P; Gorzanelli A; Colombo MP; Piconese S. 2011. Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells. Eur J Immunol 41(12):3615-26. [PubMed: 22229156]  [MGI Ref ID J:179655]

Calzascia T; Pellegrini M; Lin A; Garza KM; Elford AR; Shahinian A; Ohashi PS; Mak TW. 2008. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A 105(8):2999-3004. [PubMed: 18287017]  [MGI Ref ID J:132821]

Campos-Neto A; Ovendale P; Bement T; Koppi TA; Fanslow WC; Rossi MA; Alderson MR. 1998. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 160(5):2037-41. [PubMed: 9498737]  [MGI Ref ID J:123032]

Cao L; Palmer CD; Malon JT; De Leo JA. 2009. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain. Eur J Immunol 39(12):3562-9. [PubMed: 19750482]  [MGI Ref ID J:154932]

Carragher DM; Kaminski DA; Moquin A; Hartson L; Randall TD. 2008. A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus. J Immunol 181(6):4168-76. [PubMed: 18768874]  [MGI Ref ID J:139087]

Chaplin JW; Chappell CP; Clark EA. 2013. Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory. J Exp Med 210(10):2135-46. [PubMed: 24019553]  [MGI Ref ID J:204086]

Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002]  [MGI Ref ID J:191423]

Chen GH; Osterholzer JJ; Choe MY; McDonald RA; Olszewski MA; Huffnagle GB; Toews GB. 2010. Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung. Am J Pathol 177(5):2459-71. [PubMed: 20864680]  [MGI Ref ID J:166256]

Chen L; Arora M; Yarlagadda M; Oriss TB; Krishnamoorthy N; Ray A; Ray P. 2006. Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide. J Immunol 177(4):2373-83. [PubMed: 16887999]  [MGI Ref ID J:138357]

Chen L; Cheng W; Shivshankar P; Lei L; Zhang X; Wu Y; Yeh IT; Zhong G. 2009. Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice. Infect Immun 77(7):3080-9. [PubMed: 19398542]  [MGI Ref ID J:150306]

Choi YS; Kageyama R; Eto D; Escobar TC; Johnston RJ; Monticelli L; Lao C; Crotty S. 2011. ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6. Immunity 34(6):932-46. [PubMed: 21636296]  [MGI Ref ID J:174012]

Collins JT; Shi J; Burrell BE; Bishop DK; Dunnick WA. 2006. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma. J Immunol 177(8):5414-9. [PubMed: 17015727]  [MGI Ref ID J:139436]

Crawford A; Macleod M; Schumacher T; Corlett L; Gray D. 2006. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 176(6):3498-506. [PubMed: 16517718]  [MGI Ref ID J:129511]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

De Santo C; Salio M; Masri SH; Lee LY; Dong T; Speak AO; Porubsky S; Booth S; Veerapen N; Besra GS; Grone HJ; Platt FM; Zambon M; Cerundolo V. 2008. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest 118(12):4036-48. [PubMed: 19033672]  [MGI Ref ID J:144728]

Deenick EK; Chan A; Ma CS; Gatto D; Schwartzberg PL; Brink R; Tangye SG. 2010. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33(2):241-53. [PubMed: 20691615]  [MGI Ref ID J:163920]

DiPaolo RJ; Unanue ER. 2002. Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6. [PubMed: 12218093]  [MGI Ref ID J:120434]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dibra D; Cutrera JJ; Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol 188(8):3709-15. [PubMed: 22407920]  [MGI Ref ID J:184078]

Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390]  [MGI Ref ID J:113556]

Fang M; Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol 175(10):6829-36. [PubMed: 16272340]  [MGI Ref ID J:119697]

Fillatreau S; Gray D. 2003. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 197(2):195-206. [PubMed: 12538659]  [MGI Ref ID J:124822]

Florido M; Goncalves AS; Gomes MS; Appelberg R. 2004. CD40 is required for the optimal induction of protective immunity to Mycobacterium avium. Immunology 111(3):323-7. [PubMed: 15009433]  [MGI Ref ID J:88471]

Fuse S; Tsai CY; Molloy MJ; Allie SR; Zhang W; Yagita H; Usherwood EJ. 2009. Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1. J Immunol 182(7):4244-54. [PubMed: 19299723]  [MGI Ref ID J:147123]

Gaspal FM; McConnell FM; Kim MY; Gray D; Kosco-Vilbois MH; Raykundalia CR; Botto M; Lane PJ. 2006. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur J Immunol 36(7):1665-73. [PubMed: 16783845]  [MGI Ref ID J:115798]

Giannoni F; Shea A; Inglis C; Lee LN; Sarawar SR. 2008. CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68. J Virol 82(22):11016-22. [PubMed: 18768977]  [MGI Ref ID J:142958]

Glauert HP; Eyigor A; Tharappel JC; Cooper S; Lee EY; Spear BT. 2006. Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643. Toxicol Sci 90(2):331-6. [PubMed: 16434500]  [MGI Ref ID J:113288]

Guarda G; Dostert C; Staehli F; Cabalzar K; Castillo R; Tardivel A; Schneider P; Tschopp J. 2009. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460(7252):269-73. [PubMed: 19494813]  [MGI Ref ID J:150357]

Guiducci C; Valzasina B; Dislich H; Colombo MP. 2005. CD40/CD40L interaction regulates CD4(+)CD25(+) T reg homeostasis through dendritic cell-produced IL-2. Eur J Immunol 35(2):557-67. [PubMed: 15682445]  [MGI Ref ID J:95614]

Guo CA; Kogan S; Amano SU; Wang M; Dagdeviren S; Friedline RH; Aouadi M; Kim JK; Czech MP. 2013. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab 304(9):E951-63. [PubMed: 23482447]  [MGI Ref ID J:198130]

Gupta S; Boppana R; Mishra GC; Saha B; Mitra D. 2008. Interleukin-12 is necessary for the priming of CD4+ T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology 124(4):553-61. [PubMed: 18298551]  [MGI Ref ID J:142777]

Hao S; Yuan J; Xiang J. 2007. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol 82(4):829-38. [PubMed: 17626150]  [MGI Ref ID J:125204]

Hashimoto N; Kawabe T; Imaizumi K; Hara T; Okamoto M; Kojima K; Shimokata K; Hasegawa Y. 2004. CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury. Am J Respir Cell Mol Biol 30(6):808-15. [PubMed: 14693668]  [MGI Ref ID J:99677]

Hayakawa Y; Takeda K; Yagita H; Van Kaer L; Saiki I; Okumura K. 2001. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol 166(10):6012-8. [PubMed: 11342617]  [MGI Ref ID J:110892]

Heer AK; Shamshiev A; Donda A; Uematsu S; Akira S; Kopf M; Marsland BJ. 2007. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J Immunol 178(4):2182-91. [PubMed: 17277123]  [MGI Ref ID J:143991]

Hernandez MG; Shen L; Rock KL. 2008. CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help. J Immunol 180(7):4382-90. [PubMed: 18354158]  [MGI Ref ID J:132973]

Hernandez MG; Shen L; Rock KL. 2007. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol 178(5):2844-52. [PubMed: 17312128]  [MGI Ref ID J:144111]

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Skok J; Poudrier J; Gray D. 1999. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol 163(8):4284-91. [PubMed: 10510367]  [MGI Ref ID J:119232]

Song Z; Jin R; Yu S; Nanda A; Granger DN; Li G. 2012. Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions. Arterioscler Thromb Vasc Biol 32(1):50-64. [PubMed: 21998133]  [MGI Ref ID J:195981]

Song Z; Jin R; Yu S; Rivet JJ; Smyth SS; Nanda A; Granger DN; Li G. 2011. CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury. PLoS One 6(8):e23239. [PubMed: 21876738]  [MGI Ref ID J:176348]

Srivastava N; Sudan R; Saha B. 2011. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J Immunol 186(10):5863-72. [PubMed: 21471446]  [MGI Ref ID J:173097]

Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 296(3):H689-97. [PubMed: 19112095]  [MGI Ref ID J:146361]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Stunz LL; Busch LK; Munroe ME; Sigmund CD; Tygrett LT; Waldschmidt TJ; Bishop GA. 2004. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity 21(2):255-66. [PubMed: 15308105]  [MGI Ref ID J:93594]

Sudan R; Srivastava N; Pandey SP; Majumdar S; Saha B. 2012. Reciprocal regulation of protein kinase C isoforms results in differential cellular responsiveness. J Immunol 188(5):2328-37. [PubMed: 22271653]  [MGI Ref ID J:181276]

Sun JC; Bevan MJ. 2004. Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J Immunol 172(6):3385-9. [PubMed: 15004136]  [MGI Ref ID J:88609]

Takahashi H; Ebihara S; Kanda A; Kamanaka M; Sato T; Habu S; Kikutani H; Sasaki H. 2003. Increased susceptibility to airway responses in CD40-deficient mice. Clin Exp Immunol 133(1):22-9. [PubMed: 12823274]  [MGI Ref ID J:109818]

Tomura M; Yu WG; Ahn HJ; Yamashita M; Yang YF; Ono S; Hamaoka T; Kawano T; Taniguchi M; Koezuka Y; Fujiwara H. 1999. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol 163(1):93-101. [PubMed: 10384104]  [MGI Ref ID J:119894]

Tonti E; Fedeli M; Napolitano A; Iannacone M; von Andrian UH; Guidotti LG; Abrignani S; Casorati G; Dellabona P. 2012. Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help. J Immunol 188(7):3217-22. [PubMed: 22379027]  [MGI Ref ID J:183101]

Tonti E; Galli G; Malzone C; Abrignani S; Casorati G; Dellabona P. 2009. NKT-cell help to B lymphocytes can occur independently of cognate interaction. Blood 113(2):370-6. [PubMed: 18832653]  [MGI Ref ID J:144427]

Umeshappa CS; Nanjundappa RH; Xie Y; Freywald A; Xu Q; Xiang J. 2013. Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency. Immunology 138(4):298-306. [PubMed: 23113741]  [MGI Ref ID J:198091]

Van Deusen KE; Rajapakse R; Bullock TN. 2010. CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses. J Leukoc Biol 87(3):477-85. [PubMed: 19952354]  [MGI Ref ID J:158863]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vieyra M; Leisman S; Raedler H; Kwan WH; Yang M; Strainic MG; Medof ME; Heeger PS. 2011. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol 179(2):766-74. [PubMed: 21704012]  [MGI Ref ID J:174402]

Vitry MA; De Trez C; Goriely S; Dumoutier L; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun 80(12):4271-80. [PubMed: 23006848]  [MGI Ref ID J:190620]

Vowinkel T; Anthoni C; Wood KC; Stokes KY; Russell J; Gray L; Bharwani S; Senninger N; Alexander JS; Krieglstein CF; Grisham MB; Granger DN. 2007. CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon. Gastroenterology 132(3):955-65. [PubMed: 17324402]  [MGI Ref ID J:128219]

Vowinkel T; Wood KC; Stokes KY; Russell J; Krieglstein CF; Granger DN. 2006. Differential expression and regulation of murine CD40 in regional vascular beds. Am J Physiol Heart Circ Physiol 290(2):H631-9. [PubMed: 16172156]  [MGI Ref ID J:106724]

Wakayama H; Hasegawa Y; Kawabe T; Hara T; Matsuo S; Mizuno M; Takai T; Kikutani H; Shimokata K. 2000. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Eur J Immunol 30(4):1182-90. [PubMed: 10760808]  [MGI Ref ID J:61673]

Wang X; Li H; Matte-Martone C; Cui W; Li N; Tan HS; Roopenian D; Shlomchik WD. 2011. Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. Blood 118(24):6426-37. [PubMed: 21963602]  [MGI Ref ID J:179099]

White AJ; Withers DR; Parnell SM; Scott HS; Finke D; Lane PJ; Jenkinson EJ; Anderson G. 2008. Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol 38(4):942-7. [PubMed: 18350550]  [MGI Ref ID J:133775]

Wiesel M; Joller N; Ehlert AK; Crouse J; Sporri R; Bachmann MF; Oxenius A. 2010. Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses. J Immunol 185(9):5188-97. [PubMed: 20881183]  [MGI Ref ID J:165190]

Willer DO; Speck SH. 2005. Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40. J Virol 79(5):2891-9. [PubMed: 15709008]  [MGI Ref ID J:96699]

Williams JA; Zhang J; Jeon H; Nitta T; Ohigashi I; Klug D; Kruhlak MJ; Choudhury B; Sharrow SO; Granger L; Adams A; Eckhaus MA; Jenkinson SR; Richie ER; Gress RE; Takahama Y; Hodes RJ. 2014. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol 192(2):630-40. [PubMed: 24337745]  [MGI Ref ID J:207324]

Wong KL; Lew FC; MacAry PA; Kemeny DM. 2008. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol 38(8):2251-62. [PubMed: 18600823]  [MGI Ref ID J:138592]

Wuthrich M; Fisette PL; Filutowicz HI; Klein BS. 2006. Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis. J Immunol 176(9):5538-47. [PubMed: 16622023]  [MGI Ref ID J:131650]

Wykes M; MacPherson G. 2000. Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology 100(1):1-3. [PubMed: 10809952]  [MGI Ref ID J:110408]

Yacoub D; Hachem A; Theoret JF; Gillis MA; Mourad W; Merhi Y. 2010. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. Arterioscler Thromb Vasc Biol 30(12):2424-33. [PubMed: 21071692]  [MGI Ref ID J:183202]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269]  [MGI Ref ID J:149301]

Yasui T; Muraoka M; Takaoka-Shichijo Y; Ishida I; Takegahara N; Uchida J; Kumanogoh A; Suematsu S; Suzuki M; Kikutani H. 2002. Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 14(3):319-29. [PubMed: 11867568]  [MGI Ref ID J:113575]

Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Zhao Y; Wilson D; Matthews S; Yap GS. 2007. Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling. Infect Immun 75(10):4799-803. [PubMed: 17682046]  [MGI Ref ID J:125278]

Zirlik A; Maier C; Gerdes N; MacFarlane L; Soosairajah J; Bavendiek U; Ahrens I; Ernst S; Bassler N; Missiou A; Patko Z; Aikawa M; Schonbeck U; Bode C; Libby P; Peter K. 2007. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 115(12):1571-80. [PubMed: 17372166]  [MGI Ref ID J:133045]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   See control note: The Jackson Laboratory does not have the BALB/cAnNcr substrain. BALB/cByJ mice(Stock No. 001026) are the most closely related substrain and may be used as a control although we have not tested histocompatibility between the two strains.
   001026 BALB/cByJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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