Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names CNCr.129P2-Tnfrsf5tm1Kik/J    (Changed: 30-SEP-05 ) Cd40    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain BALB/cAnNcr Donor Strain 129P2 via E14-1 ES cell line Generation ?+F1p (03-JUL-05) Generation Definitions   Donating Investigator Hitoshi Kikutani,   Osaka University

Appearance
albino
Related Genotype: Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c

Description
Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.

Control Information

	Control
	See control note:	The Jackson Laboratory does not have the BALB/cAnNcr substrain. BALB/cByJ mice(Stock No. 001026) are the most closely related substrain and may be used as a control although we have not tested histocompatibility between the two strains.
	001026 BALB/cByJ
Considerations for Choosing Controls

Related Strains

Strains carrying   Cd40^tm1Kik allele

002928

B6.129P2-Cd40tm1Kik/J

View Strains carrying   Cd40^tm1Kik     (1 strain)

Strains carrying other alleles of Cd40

002928

B6.129P2-Cd40tm1Kik/J

View Strains carrying other alleles of Cd40     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Cd40^tm1Kik/Cd40^tm1Kik

        B6.129P2-Cd40^tm1Kik/J

• hematopoietic system phenotype
• *normal* hematopoietic system phenotype
  • normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles   (MGI Ref ID J:75152)
• immune system phenotype
• abnormal dendritic cell physiology
  • impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7   (MGI Ref ID J:86998)
  • impaired priming of IFN-gamma producing T cells   (MGI Ref ID J:86998)
• increased susceptibility to bacterial infection
  • increased susceptibility to aerosol Mycobacterium tuberculosis infection   (MGI Ref ID J:86998)
  • increased bacterial loads in lung and spleen   (MGI Ref ID J:86998)
  • 40% of infected mice moribund 3 - 4 weeks postinfection   (MGI Ref ID J:86998)

Cd40^tm1Kik/Cd40^tm1Kik

        involves: 129P2/OlaHsd * C57BL/6

• hematopoietic system phenotype
• absent spleen germinal center
  • failed to form   (MGI Ref ID J:25007)
• decreased neutrophil cell number
  • in non-SPF facilities compared to wild-type controls   (MGI Ref ID J:25007)
• immune system phenotype
• *normal* immune system phenotype
  • normal numbers and ratios of T and B cells   (MGI Ref ID J:25007)
• • abnormal humoral immune response   (MGI Ref ID J:25007)
  • • decreased immunoglobulin level
      • reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
      • response to thymus-independent (TI) antigens was in tact   (MGI Ref ID J:25007)
    • • decreased IgA level
        • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
      • decreased IgE level
        • reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • decreased serum concentrations in unimmunized mice   (MGI Ref ID J:25007)
      • decreased IgG1 level
        • reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • decreased serum concentrations of IgG1 in unimmunized mice   (MGI Ref ID J:25007)
      • decreased IgG2a level
        • reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • decreased serum concentrations of IgG2a in unimmunized mice   (MGI Ref ID J:25007)
      • decreased IgG2b level
        • reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • decreased serum concentrations of IgG2b in unimmunized mice   (MGI Ref ID J:25007)
      • decreased IgG3 level
        • reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin   (MGI Ref ID J:25007)
        • IgG3 serum concentrations in unimmunized mice are not decreased   (MGI Ref ID J:25007)
  • absent spleen germinal center
    • failed to form   (MGI Ref ID J:25007)
  • decreased neutrophil cell number
    • in non-SPF facilities compared to wild-type controls   (MGI Ref ID J:25007)
  • decreased susceptibility to type II hypersensitivity reaction
    • in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis   (MGI Ref ID J:61673)
    • deposition of IgG and complement in glomeruli not observed   (MGI Ref ID J:61673)
    • glomeruli almost normal   (MGI Ref ID J:61673)
    • fibrin deposition in glomeruli not observed   (MGI Ref ID J:61673)
    • failure to induce proteinuria   (MGI Ref ID J:61673)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Sensorineural Research
Nociception

Cd40^tm1Kik related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Cd40tm1Kik
Allele Name		targeted mutation 1, Hitoshi Kikutani
Allele Type		Targeted (knock-out)
Common Name(s)		CD40 Ko; CD40-; CD40KO; Tnfrsf5-; Tnfrsf5tm1Kik;
Mutation Made By		Hitoshi Kikutani,   Osaka University
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14.1
ES Cell Line Strain		129P2/OlaHsd
Gene Symbol and Name		Cd40, CD40 antigen
Chromosome		2
Gene Common Name(s)		AI326936; Bp50; CDW40; TNFRSF5; Tnfrsf5; expressed sequence AI326936; p50; tumor necrosis factor receptor superfamily, member 5;
Molecular Note		A neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed. [MGI Ref ID J:25007]

Genotyping

Genotyping Information

Genotyping Protocols

Cd40^tm1Kik, Separated PCR

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Kawabe T; Naka T; Yoshida K; Tanaka T; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T; Kikutani H. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1(3):167-78. [PubMed: 7534202]  [MGI Ref ID J:25007]

Additional References

Montfort MJ; Bouwer HG; Wagner CR; Hinrichs DJ. 2004. The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40. J Immunol 173(6):4084-90. [PubMed: 15356158]  [MGI Ref ID J:92749]

Ruedl C; Bachmann MF; Kopf M. 2000. The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur J Immunol 30(7):2056-64. [PubMed: 10940895]  [MGI Ref ID J:63646]

Cd40^tm1Kik related

Aiba Y; Yamazaki T; Okada T; Gotoh K; Sanjo H; Ogata M; Kurosaki T. 2006. BANK negatively regulates Akt activation and subsequent B cell responses. Immunity 24(3):259-68. [PubMed: 16546095]  [MGI Ref ID J:113321]

Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340-8. [PubMed: 16081804]  [MGI Ref ID J:107507]

Akiyama T; Shimo Y; Yanai H; Qin J; Ohshima D; Maruyama Y; Asaumi Y; Kitazawa J; Takayanagi H; Penninger JM; Matsumoto M; Nitta T; Takahama Y; Inoue J. 2008. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29(3):423-37. [PubMed: 18799149]  [MGI Ref ID J:139649]

Anderson BE; McNiff JM; Jain D; Blazar BR; Shlomchik WD; Shlomchik MJ. 2005. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105(5):2227-34. [PubMed: 15522961]  [MGI Ref ID J:98140]

Andre P; Prasad KS; Denis CV; He M; Papalia JM; Hynes RO; Phillips DR; Wagner DD. 2002. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med 8(3):247-52. [PubMed: 11875495]  [MGI Ref ID J:75152]

Bachmann MF; Schwarz K; Wolint P; Meijerink E; Martin S; Manolova V; Oxenius A. 2004. Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells. J Immunol 173(4):2217-21. [PubMed: 15294930]  [MGI Ref ID J:92734]

Bachmann MF; Wong BR; Josien R; Steinman RM; Oxenius A; Choi Y. 1999. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med 189(7):1025-31. [PubMed: 10190893]  [MGI Ref ID J:111460]

Bergthorsdottir S; Gallagher A; Jainandunsing S; Cockayne D; Sutton J; Leanderson T; Gray D. 2001. Signals that initiate somatic hypermutation of B cells in vitro. J Immunol 166(4):2228-34. [PubMed: 11160276]  [MGI Ref ID J:127146]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Bhadra R; Gigley JP; Khan IA. 2011. Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. J Immunol 187(9):4421-5. [PubMed: 21949017]  [MGI Ref ID J:179445]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Bourgeois C; Rocha B; Tanchot C. 2002. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297(5589):2060-3. [PubMed: 12242444]  [MGI Ref ID J:127835]

Buhlmann JE; Elkin SK; Sharpe AH. 2003. A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8. [PubMed: 12759417]  [MGI Ref ID J:83454]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burocchi A; Pittoni P; Gorzanelli A; Colombo MP; Piconese S. 2011. Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells. Eur J Immunol 41(12):3615-26. [PubMed: 22229156]  [MGI Ref ID J:179655]

Calzascia T; Pellegrini M; Lin A; Garza KM; Elford AR; Shahinian A; Ohashi PS; Mak TW. 2008. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A 105(8):2999-3004. [PubMed: 18287017]  [MGI Ref ID J:132821]

Campos-Neto A; Ovendale P; Bement T; Koppi TA; Fanslow WC; Rossi MA; Alderson MR. 1998. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 160(5):2037-41. [PubMed: 9498737]  [MGI Ref ID J:123032]

Cao L; Palmer CD; Malon JT; De Leo JA. 2009. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain. Eur J Immunol 39(12):3562-9. [PubMed: 19750482]  [MGI Ref ID J:154932]

Carragher DM; Kaminski DA; Moquin A; Hartson L; Randall TD. 2008. A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus. J Immunol 181(6):4168-76. [PubMed: 18768874]  [MGI Ref ID J:139087]

Chen GH; Osterholzer JJ; Choe MY; McDonald RA; Olszewski MA; Huffnagle GB; Toews GB. 2010. Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung. Am J Pathol 177(5):2459-71. [PubMed: 20864680]  [MGI Ref ID J:166256]

Chen L; Arora M; Yarlagadda M; Oriss TB; Krishnamoorthy N; Ray A; Ray P. 2006. Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide. J Immunol 177(4):2373-83. [PubMed: 16887999]  [MGI Ref ID J:138357]

Chen L; Cheng W; Shivshankar P; Lei L; Zhang X; Wu Y; Yeh IT; Zhong G. 2009. Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice. Infect Immun 77(7):3080-9. [PubMed: 19398542]  [MGI Ref ID J:150306]

Choi YS; Kageyama R; Eto D; Escobar TC; Johnston RJ; Monticelli L; Lao C; Crotty S. 2011. ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6. Immunity 34(6):932-46. [PubMed: 21636296]  [MGI Ref ID J:174012]

Collins JT; Shi J; Burrell BE; Bishop DK; Dunnick WA. 2006. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma. J Immunol 177(8):5414-9. [PubMed: 17015727]  [MGI Ref ID J:139436]

Crawford A; Macleod M; Schumacher T; Corlett L; Gray D. 2006. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 176(6):3498-506. [PubMed: 16517718]  [MGI Ref ID J:129511]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

De Santo C; Salio M; Masri SH; Lee LY; Dong T; Speak AO; Porubsky S; Booth S; Veerapen N; Besra GS; Grone HJ; Platt FM; Zambon M; Cerundolo V. 2008. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest 118(12):4036-48. [PubMed: 19033672]  [MGI Ref ID J:144728]

Deenick EK; Chan A; Ma CS; Gatto D; Schwartzberg PL; Brink R; Tangye SG. 2010. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33(2):241-53. [PubMed: 20691615]  [MGI Ref ID J:163920]

DiPaolo RJ; Unanue ER. 2002. Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6. [PubMed: 12218093]  [MGI Ref ID J:120434]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390]  [MGI Ref ID J:113556]

Fang M; Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol 175(10):6829-36. [PubMed: 16272340]  [MGI Ref ID J:119697]

Fillatreau S; Gray D. 2003. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 197(2):195-206. [PubMed: 12538659]  [MGI Ref ID J:124822]

Florido M; Goncalves AS; Gomes MS; Appelberg R. 2004. CD40 is required for the optimal induction of protective immunity to Mycobacterium avium. Immunology 111(3):323-7. [PubMed: 15009433]  [MGI Ref ID J:88471]

Fuse S; Tsai CY; Molloy MJ; Allie SR; Zhang W; Yagita H; Usherwood EJ. 2009. Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1. J Immunol 182(7):4244-54. [PubMed: 19299723]  [MGI Ref ID J:147123]

Gaspal FM; McConnell FM; Kim MY; Gray D; Kosco-Vilbois MH; Raykundalia CR; Botto M; Lane PJ. 2006. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur J Immunol 36(7):1665-73. [PubMed: 16783845]  [MGI Ref ID J:115798]

Giannoni F; Shea A; Inglis C; Lee LN; Sarawar SR. 2008. CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68. J Virol 82(22):11016-22. [PubMed: 18768977]  [MGI Ref ID J:142958]

Glauert HP; Eyigor A; Tharappel JC; Cooper S; Lee EY; Spear BT. 2006. Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643. Toxicol Sci 90(2):331-6. [PubMed: 16434500]  [MGI Ref ID J:113288]

Guarda G; Dostert C; Staehli F; Cabalzar K; Castillo R; Tardivel A; Schneider P; Tschopp J. 2009. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460(7252):269-73. [PubMed: 19494813]  [MGI Ref ID J:150357]

Guiducci C; Valzasina B; Dislich H; Colombo MP. 2005. CD40/CD40L interaction regulates CD4(+)CD25(+) T reg homeostasis through dendritic cell-produced IL-2. Eur J Immunol 35(2):557-67. [PubMed: 15682445]  [MGI Ref ID J:95614]

Gupta S; Boppana R; Mishra GC; Saha B; Mitra D. 2008. Interleukin-12 is necessary for the priming of CD4+ T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology 124(4):553-61. [PubMed: 18298551]  [MGI Ref ID J:142777]

Hao S; Yuan J; Xiang J. 2007. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol 82(4):829-38. [PubMed: 17626150]  [MGI Ref ID J:125204]

Hashimoto N; Kawabe T; Imaizumi K; Hara T; Okamoto M; Kojima K; Shimokata K; Hasegawa Y. 2004. CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury. Am J Respir Cell Mol Biol 30(6):808-15. [PubMed: 14693668]  [MGI Ref ID J:99677]

Hayakawa Y; Takeda K; Yagita H; Van Kaer L; Saiki I; Okumura K. 2001. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol 166(10):6012-8. [PubMed: 11342617]  [MGI Ref ID J:110892]

Heer AK; Shamshiev A; Donda A; Uematsu S; Akira S; Kopf M; Marsland BJ. 2007. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J Immunol 178(4):2182-91. [PubMed: 17277123]  [MGI Ref ID J:143991]

Hernandez MG; Shen L; Rock KL. 2008. CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help. J Immunol 180(7):4382-90. [PubMed: 18354158]  [MGI Ref ID J:132973]

Hernandez MG; Shen L; Rock KL. 2007. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol 178(5):2844-52. [PubMed: 17312128]  [MGI Ref ID J:144111]

Higuchi T; Aiba Y; Nomura T; Matsuda J; Mochida K; Suzuki M; Kikutani H; Honjo T; Nishioka K; Tsubata T. 2002. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 168(1):9-12. [PubMed: 11751940]  [MGI Ref ID J:128824]

Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150]  [MGI Ref ID J:139648]

Hochweller K; Anderton SM. 2004. Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration. Eur J Immunol 34(4):990-8. [PubMed: 15048709]  [MGI Ref ID J:88882]

Hochweller K; Sweenie CH; Anderton SM. 2006. Circumventing tolerance at the T cell or the antigen-presenting cell surface: antibodies that ligate CD40 and OX40 have different effects. Eur J Immunol 36(2):389-96. [PubMed: 16402409]  [MGI Ref ID J:113856]

Hou H; Obregon D; Lou D; Ehrhart J; Fernandez F; Silver A; Tan J. 2008. Modulation of neuronal differentiation by CD40 isoforms. Biochem Biophys Res Commun 369(2):641-7. [PubMed: 18312851]  [MGI Ref ID J:134173]

Idoyaga J; Lubkin A; Fiorese C; Lahoud MH; Caminschi I; Huang Y; Rodriguez A; Clausen BE; Park CG; Trumpfheller C; Steinman RM. 2011. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci U S A 108(6):2384-9. [PubMed: 21262813]  [MGI Ref ID J:169105]

Inoue S; Leitner WW; Golding B; Scott D. 2006. Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15):7741-7. [PubMed: 16885377]  [MGI Ref ID J:112103]

Irla M; Hugues S; Gill J; Nitta T; Hikosaka Y; Williams IR; Hubert FX; Scott HS; Takahama Y; Hollander GA; Reith W. 2008. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29(3):451-63. [PubMed: 18799151]  [MGI Ref ID J:139647]

Ishikawa M; Vowinkel T; Stokes KY; Arumugam TV; Yilmaz G; Nanda A; Granger DN. 2005. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Circulation 111(13):1690-6. [PubMed: 15795333]  [MGI Ref ID J:108988]

Jenkins SJ; Perona-Wright G; MacDonald AS. 2008. Full development of Th2 immunity requires both innate and adaptive sources of CD154. J Immunol 180(12):8083-92. [PubMed: 18523272]  [MGI Ref ID J:137237]

Jeurissen A; Billiau AD; Moens L; Shengqiao L; Landuyt W; Wuyts G; Boon L; Waer M; Ceuppens JL; Bossuyt X. 2006. CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type. J Immunol 176(1):529-36. [PubMed: 16365447]  [MGI Ref ID J:126613]

Kastenmuller W; Gasteiger G; Subramanian N; Sparwasser T; Busch DH; Belkaid Y; Drexler I; Germain RN. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187(6):3186-97. [PubMed: 21849683]  [MGI Ref ID J:179230]

Kawamura T; Kanai T; Dohi T; Uraushihara K; Totsuka T; Iiyama R; Taneda C; Yamazaki M; Nakamura T; Higuchi T; Aiba Y; Tsubata T; Watanabe M. 2004. Ectopic CD40 ligand expression on B cells triggers intestinal inflammation. J Immunol 172(10):6388-97. [PubMed: 15128830]  [MGI Ref ID J:89855]

Khiong K; Murakami M; Kitabayashi C; Ueda N; Sawa S; Sakamoto A; Kotzin BL; Rozzo SJ; Ishihara K; Verella-Garcia M; Kappler J; Marrack P; Hirano T. 2007. Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest 117(5):1270-81. [PubMed: 17476359]  [MGI Ref ID J:122142]

Kishi Y; Aiba Y; Higuchi T; Furukawa K; Tokuhisa T; Takemori T; Tsubata T. 2010. Augmented antibody response with premature germinal center regression in CD40L transgenic mice. J Immunol 185(1):211-9. [PubMed: 20505144]  [MGI Ref ID J:161443]

Kobayashi T; Kim TS; Jacob A; Walsh MC; Kadono Y; Fuentes-Panana E; Yoshioka T; Yoshimura A; Yamamoto M; Kaisho T; Akira S; Monroe JG; Choi Y. 2009. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS ONE 4(3):e4736. [PubMed: 19270748]  [MGI Ref ID J:147371]

Koschella M; Voehringer D; Pircher H. 2004. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol 172(8):4804-11. [PubMed: 15067057]  [MGI Ref ID J:89113]

Kraus ZJ; Nakano H; Bishop GA. 2009. TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc Natl Acad Sci U S A 106(40):17140-5. [PubMed: 19805155]  [MGI Ref ID J:153675]

Kurche JS; Burchill MA; Sanchez PJ; Haluszczak C; Kedl RM. 2010. Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses. J Immunol 185(4):2106-15. [PubMed: 20639485]  [MGI Ref ID J:162543]

Kuwajima S; Sato T; Ishida K; Tada H; Tezuka H; Ohteki T. 2006. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7(7):740-6. [PubMed: 16715101]  [MGI Ref ID J:112665]

Laporte V; Ait-Ghezala G; Volmar CH; Ganey C; Ganey N; Wood M; Mullan M. 2008. CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. Brain Res 1231:132-42. [PubMed: 18606155]  [MGI Ref ID J:139872]

Lazarevic V; Myers AJ; Scanga CA; Flynn JL. 2003. CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity 19(6):823-35. [PubMed: 14670300]  [MGI Ref ID J:86998]

Lee BO; Rangel-Moreno J; Moyron-Quiroz JE; Hartson L; Makris M; Sprague F; Lund FE; Randall TD. 2005. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol 175(9):5827-38. [PubMed: 16237075]  [MGI Ref ID J:119355]

Li H; Matte-Martone C; Tan HS; Venkatesan S; McNiff J; Demetris AJ; Jain D; Lakkis F; Rothstein D; Shlomchik WD. 2011. Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells. J Immunol 186(1):230-41. [PubMed: 21098219]  [MGI Ref ID J:168013]

Li W; Buzoni-Gatel D; Debbabi H; Hu MS; Mennechet FJ; Durell BG; Noelle RJ; Kasper LH. 2002. CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice. Gastroenterology 122(3):762-73. [PubMed: 11875009]  [MGI Ref ID J:75019]

Li Y; Toraldo G; Li A; Yang X; Zhang H; Qian WP; Weitzmann MN. 2007. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood 109(9):3839-48. [PubMed: 17202317]  [MGI Ref ID J:145330]

Lievens D; Zernecke A; Seijkens T; Soehnlein O; Beckers L; Munnix IC; Wijnands E; Goossens P; van Kruchten R; Thevissen L; Boon L; Flavell RA; Noelle RJ; Gerdes N; Biessen EA; Daemen MJ; Heemskerk JW; Weber C; Lutgens E. 2010. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 116(20):4317-27. [PubMed: 20705757]  [MGI Ref ID J:166644]

Liu X; Zhan Z; Li D; Xu L; Ma F; Zhang P; Yao H; Cao X. 2011. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12(5):416-24. [PubMed: 21441935]  [MGI Ref ID J:171920]

Liu Z; Noh HS; Chen J; Kim JH; Falo LD Jr; You Z. 2008. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J Immunol 181(6):4363-70. [PubMed: 18768895]  [MGI Ref ID J:139077]

Lu Z; Yuan L; Zhou X; Sotomayor E; Levitsky HI; Pardoll DM. 2000. CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes. J Exp Med 191(3):541-50. [PubMed: 10662799]  [MGI Ref ID J:115118]

Lukin K; Cosyns M; Mitchell T; Saffry M; Hayward A. 2000. Eradication of Cryptosporidium parvum infection by mice with ovalbumin-specific T cells. Infect Immun 68(5):2663-70. [PubMed: 10768958]  [MGI Ref ID J:61705]

MacLeod M; Kwakkenbos MJ; Crawford A; Brown S; Stockinger B; Schepers K; Schumacher T; Gray D. 2006. CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. J Exp Med 203(4):897-906. [PubMed: 16549596]  [MGI Ref ID J:123754]

Mackey MF; Gunn JR; Maliszewsky C; Kikutani H; Noelle RJ; Barth RJ Jr. 1998. Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J Immunol 161(5):2094-8. [PubMed: 9725199]  [MGI Ref ID J:118387]

Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996]  [MGI Ref ID J:107458]

Martin S; Agarwal R; Murugaiyan G; Saha B. 2010. CD40 expression levels modulate regulatory T cells in Leishmania donovani infection. J Immunol 185(1):551-9. [PubMed: 20525887]  [MGI Ref ID J:161615]

Martin S; Pahari S; Sudan R; Saha B. 2010. CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions. J Immunol 184(10):5510-8. [PubMed: 20400702]  [MGI Ref ID J:160994]

Martin-Fontecha A; Baumjohann D; Guarda G; Reboldi A; Hons M; Lanzavecchia A; Sallusto F. 2008. CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med 205(11):2561-74. [PubMed: 18838544]  [MGI Ref ID J:141428]

Matsuda JL; Gapin L; Baron JL; Sidobre S; Stetson DB; Mohrs M; Locksley RM; Kronenberg M. 2003. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A 100(14):8395-400. [PubMed: 12829795]  [MGI Ref ID J:126209]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Millar DG; Garza KM; Odermatt B; Elford AR; Ono N; Li Z; Ohashi PS. 2003. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat Med 9(12):1469-76. [PubMed: 14625545]  [MGI Ref ID J:99614]

Montfort MJ; Bouwer HG; Wagner CR; Hinrichs DJ. 2004. The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40. J Immunol 173(6):4084-90. [PubMed: 15356158]  [MGI Ref ID J:92749]

Mouri Y; Yano M; Shinzawa M; Shimo Y; Hirota F; Nishikawa Y; Nii T; Kiyonari H; Abe T; Uehara H; Izumi K; Tamada K; Chen L; Penninger JM; Inoue J; Akiyama T; Matsumoto M. 2011. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol 186(9):5047-57. [PubMed: 21441458]  [MGI Ref ID J:173115]

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Murugaiyan G; Martin S; Saha B. 2007. Levels of CD40 expression on dendritic cells dictate tumour growth or regression. Clin Exp Immunol 149(1):194-202. [PubMed: 17488293]  [MGI Ref ID J:123479]

Ndhlovu LC; Ishii N; Murata K; Sato T; Sugamura K. 2001. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J Immunol 167(5):2991-9. [PubMed: 11509650]  [MGI Ref ID J:119463]

Nesbeth YC; Martinez DG; Toraya S; Scarlett UK; Cubillos-Ruiz JR; Rutkowski MR; Conejo-Garcia JR. 2010. CD4+ T cells elicit host immune responses to MHC class II- ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol 184(10):5654-62. [PubMed: 20400704]  [MGI Ref ID J:160992]

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Okuno T; Nakatsuji Y; Kumanogoh A; Koguchi K; Moriya M; Fujimura H; Kikutani H; Sakoda S. 2004. Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis. J Neurochem 91(2):404-12. [PubMed: 15447673]  [MGI Ref ID J:93256]

Osmers I; Bullard DC; Barnum SR. 2005. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J Neuroimmunol 166(1-2):193-6. [PubMed: 16005524]  [MGI Ref ID J:106363]

Ozaki ME; Coren BA; Huynh TN; Redondo DJ; Kikutani H; Webb SR. 1999. CD4+ T cell responses to CD40-deficient APCs: defects in proliferation and negative selection apply only with B cells as APCs. J Immunol 163(10):5250-6. [PubMed: 10553046]  [MGI Ref ID J:109516]

Panchanathan V; Chaudhri G; Karupiah G. 2006. Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J Virol 80(13):6333-8. [PubMed: 16775321]  [MGI Ref ID J:153332]

Pasare C; Medzhitov R. 2005. Control of B-cell responses by Toll-like receptors. Nature 438(7066):364-8. [PubMed: 16292312]  [MGI Ref ID J:102766]

Pope C; Kim SK; Marzo A; Masopust D; Williams K; Jiang J; Shen H; Lefrancois L. 2001. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol 166(5):3402-9. [PubMed: 11207297]  [MGI Ref ID J:126476]

Portillo JA; Okenka G; Reed E; Subauste A; Van Grol J; Gentil K; Komatsu M; Tanaka K; Landreth G; Levine B; Subauste CS. 2010. The CD40-autophagy pathway is needed for host protection despite IFN-Gamma-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One 5(12):e14472. [PubMed: 21217818]  [MGI Ref ID J:168250]

Prlic M; Blazar BR; Khoruts A; Zell T; Jameson SC. 2001. Homeostatic expansion occurs independently of costimulatory signals. J Immunol 167(10):5664-8. [PubMed: 11698438]  [MGI Ref ID J:118723]

Qian Y; Giltiay N; Xiao J; Wang Y; Tian J; Han S; Scott M; Carter R; Jorgensen TN; Li X. 2008. Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren's syndrome. Eur J Immunol 38(8):2219-28. [PubMed: 18624351]  [MGI Ref ID J:138560]

Qian Y; Qin J; Cui G; Naramura M; Snow EC; Ware CF; Fairchild RL; Omori SA; Rickert RC; Scott M; Kotzin BL; Li X. 2004. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity 21(4):575-87. [PubMed: 15485634]  [MGI Ref ID J:93923]

Qiao G; Lei M; Li Z; Sun Y; Minto A; Fu YX; Ying H; Quigg RJ; Zhang J. 2007. Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol 179(7):4473-9. [PubMed: 17878343]  [MGI Ref ID J:152355]

Rapetti L; Meunier S; Pontoux C; Tanchot C. 2008. CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements. J Immunol 181(1):299-308. [PubMed: 18566395]  [MGI Ref ID J:137175]

Rolink A; Melchers F; Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5(4):319-30. [PubMed: 8885865]  [MGI Ref ID J:36026]

Ruth AJ; Kitching AR; Li M; Semple TJ; Timoshanko JR; Tipping PG; Holdsworth SR. 2004. An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol 173(1):136-44. [PubMed: 15210767]  [MGI Ref ID J:90932]

Ryu SJ; Jung KM; Yoo HS; Kim TW; Kim S; Chang J; Choi EY. 2009. Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60. Blood 113(18):4273-80. [PubMed: 19139082]  [MGI Ref ID J:148435]

Schneider A; Martin-Villalba A; Weih F; Vogel J; Wirth T; Schwaninger M. 1999. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 5(5):554-9. [PubMed: 10229233]  [MGI Ref ID J:124534]

Scott MJ; Hoth JJ; Stagner MK; Gardner SA; Peyton JC; Cheadle WG. 2004. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 137(3):469-77. [PubMed: 15320895]  [MGI Ref ID J:92312]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. [PubMed: 16116224]  [MGI Ref ID J:113220]

Shibasaki M; Hashimoto K; Okamoto M; Hayashi Y; Imaizumi K; Hashimoto N; Ozaki N; Yokoi T; Takagi K; Hasegawa Y; Shimokata K; Kawabe T. 2009. Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. Am J Respir Cell Mol Biol 40(5):536-42. [PubMed: 18931325]  [MGI Ref ID J:160868]

Shimizu K; Asakura M; Fujii S. 2011. Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells. J Immunol 186(10):5927-37. [PubMed: 21460206]  [MGI Ref ID J:173107]

Sitati E; McCandless EE; Klein RS; Diamond MS. 2007. CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis. J Virol 81(18):9801-11. [PubMed: 17626103]  [MGI Ref ID J:142930]

Skok J; Poudrier J; Gray D. 1999. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol 163(8):4284-91. [PubMed: 10510367]  [MGI Ref ID J:119232]

Song Z; Jin R; Yu S; Rivet JJ; Smyth SS; Nanda A; Granger DN; Li G. 2011. CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury. PLoS One 6(8):e23239. [PubMed: 21876738]  [MGI Ref ID J:176348]

Srivastava N; Sudan R; Saha B. 2011. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J Immunol 186(10):5863-72. [PubMed: 21471446]  [MGI Ref ID J:173097]

Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 296(3):H689-97. [PubMed: 19112095]  [MGI Ref ID J:146361]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Stunz LL; Busch LK; Munroe ME; Sigmund CD; Tygrett LT; Waldschmidt TJ; Bishop GA. 2004. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity 21(2):255-66. [PubMed: 15308105]  [MGI Ref ID J:93594]

Sun JC; Bevan MJ. 2004. Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J Immunol 172(6):3385-9. [PubMed: 15004136]  [MGI Ref ID J:88609]

Takahashi H; Ebihara S; Kanda A; Kamanaka M; Sato T; Habu S; Kikutani H; Sasaki H. 2003. Increased susceptibility to airway responses in CD40-deficient mice. Clin Exp Immunol 133(1):22-9. [PubMed: 12823274]  [MGI Ref ID J:109818]

Tomura M; Yu WG; Ahn HJ; Yamashita M; Yang YF; Ono S; Hamaoka T; Kawano T; Taniguchi M; Koezuka Y; Fujiwara H. 1999. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol 163(1):93-101. [PubMed: 10384104]  [MGI Ref ID J:119894]

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Van Deusen KE; Rajapakse R; Bullock TN. 2010. CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses. J Leukoc Biol 87(3):477-85. [PubMed: 19952354]  [MGI Ref ID J:158863]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vieyra M; Leisman S; Raedler H; Kwan WH; Yang M; Strainic MG; Medof ME; Heeger PS. 2011. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol 179(2):766-74. [PubMed: 21704012]  [MGI Ref ID J:174402]

Vowinkel T; Anthoni C; Wood KC; Stokes KY; Russell J; Gray L; Bharwani S; Senninger N; Alexander JS; Krieglstein CF; Grisham MB; Granger DN. 2007. CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon. Gastroenterology 132(3):955-65. [PubMed: 17324402]  [MGI Ref ID J:128219]

Vowinkel T; Wood KC; Stokes KY; Russell J; Krieglstein CF; Granger DN. 2006. Differential expression and regulation of murine CD40 in regional vascular beds. Am J Physiol Heart Circ Physiol 290(2):H631-9. [PubMed: 16172156]  [MGI Ref ID J:106724]

Wakayama H; Hasegawa Y; Kawabe T; Hara T; Matsuo S; Mizuno M; Takai T; Kikutani H; Shimokata K. 2000. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Eur J Immunol 30(4):1182-90. [PubMed: 10760808]  [MGI Ref ID J:61673]

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Zirlik A; Maier C; Gerdes N; MacFarlane L; Soosairajah J; Bavendiek U; Ahrens I; Ernst S; Bassler N; Missiou A; Patko Z; Aikawa M; Schonbeck U; Bode C; Libby P; Peter K. 2007. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 115(12):1571-80. [PubMed: 17372166]  [MGI Ref ID J:133045]

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JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.