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Strain Name:

C.C3-Tlr4Lps-d/J

Stock Number:

002930

Availability:

Level 4


Link to main datasheet for 002930

Additional References

 

Abel B; Thieblemont N; Quesniaux VJ; Brown N; Mpagi J; Miyake K; Bihl F; Ryffel B. 2002. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 169(6):3155-62. [PubMed: 12218133]  [MGI Ref ID J:78959]

Andonegui G; Bonder CS; Green F; Mullaly SC; Zbytnuik L; Raharjo E; Kubes P. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 111(7):1011-20. [PubMed: 12671050]  [MGI Ref ID J:82623]

Andonegui G; Goyert SM; Kubes P. 2002. Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol 169(4):2111-9. [PubMed: 12165539]  [MGI Ref ID J:120701]

Andonegui G; Kerfoot SM; McNagny K; Ebbert KV; Patel KD; Kubes P. 2005. Platelets express functional Toll-like receptor-4. Blood 106(7):2417-23. [PubMed: 15961512]  [MGI Ref ID J:119375]

Apte RN; Ascher O; Pluznik DH. 1977. Relationship between lipopolysaccharide-induced serum colony stimulating factor and interferon in regulation of murine granulopoiesis Exp Hematol 5(Suppl 2):12 (Abstr.).  [MGI Ref ID J:30692]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Babcock AA; Wirenfeldt M; Holm T; Nielsen HH; Dissing-Olesen L; Toft-Hansen H; Millward JM; Landmann R; Rivest S; Finsen B; Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49):12826-37. [PubMed: 17151286]  [MGI Ref ID J:116760]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barber SA; Perera PY; Vogel SN. 1995. Defective ceramide response in C3H/HeJ (Lpsd) macrophages. J Immunol 155(5):2303-5. [PubMed: 7650365]  [MGI Ref ID J:28193]

Barrett TJ; Potter ME; Strockbine NA. 1990. Evidence for participation of the macrophage in Shiga-like toxin II-induced lethality in mice. Microb Pathog 9(2):95-103. [PubMed: 2277589]  [MGI Ref ID J:25812]

Barsness KA; Arcaroli J; Harken AH; Abraham E; Banerjee A; Reznikov L; McIntyre RC. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287(3):R592-9. [PubMed: 15072965]  [MGI Ref ID J:95788]

Basu S; Kang TJ; Chen WH; Fenton MJ; Baillie L; Hibbs S; Cross AS. 2007. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 75(5):2351-8. [PubMed: 17339355]  [MGI Ref ID J:121885]

Bauer AK; Dixon D; DeGraff LM; Cho HY; Walker CR; Malkinson AM; Kleeberger SR. 2005. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. [PubMed: 16333033]  [MGI Ref ID J:104658]

Baumgarten G; Knuefermann P; Nozaki N; Sivasubramanian N; Mann DL; Vallejo JG. 2001. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183(11):1617-24. [PubMed: 11343210]  [MGI Ref ID J:120520]

Berguer PM; Mundinano J; Piazzon I; Goldbaum FA. 2006. A polymeric bacterial protein activates dendritic cells via TLR4. J Immunol 176(4):2366-72. [PubMed: 16455994]  [MGI Ref ID J:129193]

Braedel S; Radsak M; Einsele H; Latge JP; Michan A; Loeffler J; Haddad Z; Grigoleit U; Schild H; Hebart H. 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125(3):392-9. [PubMed: 15086422]  [MGI Ref ID J:89264]

Branger J; Knapp S; Weijer S; Leemans JC; Pater JM; Speelman P; Florquin S; van der Poll T. 2004. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72(2):788-94. [PubMed: 14742522]  [MGI Ref ID J:87807]

Campos MA; Rosinha GM; Almeida IC; Salgueiro XS; Jarvis BW; Splitter GA; Qureshi N; Bruna-Romero O; Gazzinelli RT; Oliveira SC. 2004. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 72(1):176-86. [PubMed: 14688095]  [MGI Ref ID J:87836]

Cao CX; Yang QW; Lv FL; Cui J; Fu HB; Wang JZ. 2007. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 353(2):509-14. [PubMed: 17188246]  [MGI Ref ID J:117223]

Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. [PubMed: 17372179]  [MGI Ref ID J:133065]

Cenedeze MA; Goncalves GM; Feitoza CQ; Wang PM; Damiao MJ; Bertocchi AP; Pacheco-Silva A; Camara NO. 2007. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11. [PubMed: 17362743]  [MGI Ref ID J:124472]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chung YW; Choi JH; Oh TY; Eun CS; Han DS. 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol 151(1):182-9. [PubMed: 18005362]  [MGI Ref ID J:130145]

Cole BC; Mu HH; Pennock ND; Hasebe A; Chan FV; Washburn LR; Peltier MR. 2005. Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun 73(9):6039-47. [PubMed: 16113324]  [MGI Ref ID J:100413]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Coutinho A; Moller G; Gronowicz E. 1975. Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides. J Exp Med 142(1):253-8. [PubMed: 1097575]  [MGI Ref ID J:5557]

Cunningham PN; Wang Y; Guo R; He G; Quigg RJ. 2004. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172(4):2629-35. [PubMed: 14764737]  [MGI Ref ID J:88059]

Curran CS; Demick KP; Mansfield JM. 2006. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242(1):23-30. [PubMed: 17034774]  [MGI Ref ID J:116741]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

Da Costa CU; Wantia N; Kirschning CJ; Busch DH; Rodriguez N; Wagner H; Miethke T. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34(10):2874. [PubMed: 15368304]  [MGI Ref ID J:92331]

Dabbagh K; Dahl ME; Stepick-Biek P; Lewis DB. 2002. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524-30. [PubMed: 11970998]  [MGI Ref ID J:113992]

De Filippo K; Henderson RB; Laschinger M; Hogg N. 2008. Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways. J Immunol 180(6):4308-15. [PubMed: 18322244]  [MGI Ref ID J:132950]

Dear JW; Yasuda H; Hu X; Hieny S; Yuen PS; Hewitt SM; Sher A; Star RA. 2006. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69(5):832-6. [PubMed: 16518342]  [MGI Ref ID J:136506]

Dumont F; Barrois R. 1976. Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha) 12(3):145-50. [PubMed: 1086804]  [MGI Ref ID J:5721]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726]  [MGI Ref ID J:88878]

Eisenbarth SC; Zhadkevich A; Ranney P; Herrick CA; Bottomly K. 2004. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 172(7):4527-34. [PubMed: 15034070]  [MGI Ref ID J:88724]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353]  [MGI Ref ID J:83020]

Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016]  [MGI Ref ID J:120023]

Frink M; Hsieh YC; Thobe BM; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 44(10):2625-30. [PubMed: 17239439]  [MGI Ref ID J:118691]

Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. [PubMed: 11748204]  [MGI Ref ID J:74569]

Geisel RE; Sakamoto K; Russell DG; Rhoades ER. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174(8):5007-15. [PubMed: 15814731]  [MGI Ref ID J:98152]

Georgel P; Jiang Z; Kunz S; Janssen E; Mols J; Hoebe K; Bahram S; Oldstone MB; Beutler B. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2):304-13. [PubMed: 17292937]  [MGI Ref ID J:124488]

Glickstein LJ; Coburn JL. 2006. Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. Am J Trop Med Hyg 75(5):964-7. [PubMed: 17123997]  [MGI Ref ID J:135947]

Glode LM; Rosenstreich DL. 1976. Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles. J Immunol 117(6):2061-6. [PubMed: 792337]  [MGI Ref ID J:5724]

Goodridge HS; Marshall FA; Else KJ; Houston KM; Egan C; Al-Riyami L; Liew FY; Harnett W; Harnett MM. 2005. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol 174(1):284-93. [PubMed: 15611251]  [MGI Ref ID J:95856]

Grobner S; Schulz S; Soldanova I; Gunst DS; Waibel M; Wesselborg S; Borgmann S; Autenrieth IB. 2007. Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells. Infect Immun 75(1):512-7. [PubMed: 17074859]  [MGI Ref ID J:116649]

Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. [PubMed: 15967420]  [MGI Ref ID J:106358]

Hasegawa T; Matsuguchi T; Noda K; Tanaka K; Kumamoto S; Shoyama Y; Yoshikai Y. 2002. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2(4):579-89. [PubMed: 11962736]  [MGI Ref ID J:76114]

Herter S; Osterloh P; Hilf N; Rechtsteiner G; Hohfeld J; Rammensee HG; Schild H. 2005. Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol 175(2):891-8. [PubMed: 16002687]  [MGI Ref ID J:100719]

Higgins SC; Lavelle EC; McCann C; Keogh B; McNeela E; Byrne P; O'Gorman B; Jarnicki A; McGuirk P; Mills KH. 2003. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 171(6):3119-27. [PubMed: 12960338]  [MGI Ref ID J:85389]

Hogan MM; Yancey KB; Vogel SN. 1989. Role of C5a in the induction of tumoricidal activity in C3H/HeJ (Lpsd) and C3H/OuJ (Lpsn) macrophages. J Leukoc Biol 46(6):565-70. [PubMed: 2509612]  [MGI Ref ID J:24638]

Hollestelle SC; De Vries MR; Van Keulen JK; Schoneveld AH; Vink A; Strijder CF; Van Middelaar BJ; Pasterkamp G; Quax PH; De Kleijn DP. 2004. Toll-like receptor 4 is involved in outward arterial remodeling. Circulation 109(3):393-8. [PubMed: 14699006]  [MGI Ref ID J:101995]

Hollingsworth JW; Whitehead G; Berman KG; Tekippe EM; Gilmour MI; Larkin JE; Quackenbush J; Schwartz DA. 2007. Genetic basis of murine antibacterial defense to streptococcal lung infection. Immunogenetics 59(9):713-24. [PubMed: 17701033]  [MGI Ref ID J:125210]

Hoshino K; Takeuchi O; Kawai T; Sanjo H; Ogawa T; Takeda Y; Takeda K; Akira S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162(7):3749-52. [PubMed: 10201887]  [MGI Ref ID J:53519]

Hsieh YC; Frink M; Thobe BM; Hsu JT; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. 17beta-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage. Mol Immunol 44(9):2165-72. [PubMed: 17182102]  [MGI Ref ID J:117916]

Huang X; Du W; McClellan SA; Barrett RP; Hazlett LD. 2006. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 47(11):4910-6. [PubMed: 17065506]  [MGI Ref ID J:123090]

Ito Y; Kawamura I; Kohda C; Tsuchiya K; Nomura T; Mitsuyama M. 2005. Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands. Int Immunol 17(12):1597-606. [PubMed: 16291660]  [MGI Ref ID J:103653]

Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. [PubMed: 15322203]  [MGI Ref ID J:92712]

Jeyaseelan S; Chu HW; Young SK; Freeman MW; Worthen GS. 2005. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 73(3):1754-63. [PubMed: 15731076]  [MGI Ref ID J:96680]

John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. [PubMed: 16034104]  [MGI Ref ID J:107284]

Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. [PubMed: 17267571]  [MGI Ref ID J:117904]

Johnson GB; Riggs BL; Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18(11):1282-4. [PubMed: 15208271]  [MGI Ref ID J:118467]

Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. [PubMed: 12730691]  [MGI Ref ID J:83088]

Jung DY; Lee H; Jung BY; Ock J; Lee MS; Lee WH; Suk K. 2005. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 174(10):6467-76. [PubMed: 15879150]  [MGI Ref ID J:99051]

Jung YW; Schoeb TR; Weaver CT; Chaplin DD. 2006. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168(5):1425-34. [PubMed: 16651610]  [MGI Ref ID J:108686]

Katz J; Zhang P; Martin M; Vogel SN; Michalek SM. 2006. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun 74(5):2809-16. [PubMed: 16622218]  [MGI Ref ID J:108092]

Kerepesi LA; Leon O; Lustigman S; Abraham D. 2005. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun 73(12):8291-7. [PubMed: 16299326]  [MGI Ref ID J:104303]

Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. [PubMed: 16622187]  [MGI Ref ID J:108095]

Kigerl KA; Lai W; Rivest S; Hart RP; Satoskar AR; Popovich PG. 2007. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102(1):37-50. [PubMed: 17403033]  [MGI Ref ID J:122597]

Kin NW; Sanders VM. 2006. CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol 176(11):6727-35. [PubMed: 16709832]  [MGI Ref ID J:131798]

Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. [PubMed: 16301658]  [MGI Ref ID J:122156]

Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. [PubMed: 11159012]  [MGI Ref ID J:108671]

Koedel U; Angele B; Rupprecht T; Wagner H; Roggenkamp A; Pfister HW; Kirschning CJ. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170(1):438-44. [PubMed: 12496429]  [MGI Ref ID J:127283]

Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD. 2008. Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem 283(18):12546-54. [PubMed: 18332137]  [MGI Ref ID J:136838]

Kozak W; Wrotek S; Kozak A. 2006. Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB. Am J Physiol Regul Integr Comp Physiol 290(4):R871-80. [PubMed: 16293680]  [MGI Ref ID J:115760]

Lange S; Delbro DS; Jennische E; Mattsby-Baltzer I. 1996. The role of the Lps gene in experimental ulcerative colitis in mice. APMIS 104(11):823-33. [PubMed: 8982246]  [MGI Ref ID J:37271]

Lee EK; Kang SM; Paik DJ; Kim JM; Youn J. 2005. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Int Immunol 17(3):325-33. [PubMed: 15684036]  [MGI Ref ID J:96356]

Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. [PubMed: 16024722]  [MGI Ref ID J:115440]

Lehnardt S; Henneke P; Lien E; Kasper DL; Volpe JJ; Bechmann I; Nitsch R; Weber JR; Golenbock DT; Vartanian T. 2006. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177(1):583-92. [PubMed: 16785556]  [MGI Ref ID J:134437]

Lehnardt S; Lachance C; Patrizi S; Lefebvre S; Follett PL; Jensen FE; Rosenberg PA; Volpe JJ; Vartanian T. 2002. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22(7):2478-86. [PubMed: 11923412]  [MGI Ref ID J:109244]

Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949]  [MGI Ref ID J:40708]

Li H; Nookala S; Bina XR; Bina JE; Re F. 2006. Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J Leukoc Biol 80(4):766-73. [PubMed: 16895974]  [MGI Ref ID J:113031]

Li Q; Cherayil BJ. 2004. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Biochem Biophys Res Commun 325(1):91-6. [PubMed: 15522205]  [MGI Ref ID J:93526]

Mahieu T; Park JM; Revets H; Pasche B; Lengeling A; Staelens J; Wullaert A; Vanlaere I; Hochepied T; van Roy F; Karin M; Libert C. 2006. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 103(7):2292-7. [PubMed: 16455798]  [MGI Ref ID J:106066]

Malley R; Henneke P; Morse SC; Cieslewicz MJ; Lipsitch M; Thompson CM; Kurt-Jones E; Paton JC; Wessels MR; Golenbock DT. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100(4):1966-71. [PubMed: 12569171]  [MGI Ref ID J:81975]

Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. [PubMed: 15501798]  [MGI Ref ID J:93263]

Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. [PubMed: 14976600]  [MGI Ref ID J:88587]

Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. [PubMed: 16299309]  [MGI Ref ID J:104298]

McCartney-Francis N; Jin W; Wahl SM. 2004. Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 172(6):3814-21. [PubMed: 15004187]  [MGI Ref ID J:88604]

Medoff BD; Wain JC; Seung E; Jackobek R; Means TK; Ginns LC; Farber JM; Luster AD. 2006. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol 176(11):7087-95. [PubMed: 16709871]  [MGI Ref ID J:131767]

Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. [PubMed: 15514106]  [MGI Ref ID J:96316]

Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901]  [MGI Ref ID J:91775]

Moeller GR; Terry L; Snyderman R. 1978. The inflammatory response and resistance to endotoxin in mice. J Immunol 120(1):116-23. [PubMed: 627714]  [MGI Ref ID J:5936]

Mollen KP; Levy RM; Prince JM; Hoffman RA; Scott MJ; Kaczorowski DJ; Vallabhaneni R; Vodovotz Y; Billiar TR. 2008. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol 83(1):80-8. [PubMed: 17925504]  [MGI Ref ID J:130089]

Mortaz E; Redegeld FA; Nijkamp FP; Wong HR; Engels F. 2006. Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway. Exp Hematol 34(1):8-18. [PubMed: 16413386]  [MGI Ref ID J:104576]

Mottillo EP; Shen XJ; Granneman JG. 2007. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab 293(5):E1188-97. [PubMed: 17711991]  [MGI Ref ID J:126761]

Mu HH; Sawitzke AD; Cole BC. 2001. Presence of Lps(d) mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis. Infect Immun 69(6):3837-44. [PubMed: 11349049]  [MGI Ref ID J:69541]

Mueller M; Postius S; Thimm JG; Gueinzius K; Muehldorfer I; Hermann C. 2004. Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology 209(8):599-608. [PubMed: 15638128]  [MGI Ref ID J:101915]

Neal MD; Leaphart C; Levy R; Prince J; Billiar TR; Watkins S; Li J; Cetin S; Ford H; Schreiber A; Hackam DJ. 2006. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176(5):3070-9. [PubMed: 16493066]  [MGI Ref ID J:129416]

Netea MG; Van Der Graaf CA; Vonk AG; Verschueren I; Van Der Meer JW; Kullberg BJ. 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 185(10):1483-9. [PubMed: 11992285]  [MGI Ref ID J:126008]

Nishikubo K; Imanaka-Yoshida K; Tamaki S; Hiroe M; Yoshida T; Adachi Y; Yasutomi Y. 2007. Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis. J Autoimmun 29(2-3):146-53. [PubMed: 17698322]  [MGI Ref ID J:125182]

Nolte MA; Leibundgut-Landmann S; Joffre O; Reis e Sousa C. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 204(6):1487-501. [PubMed: 17548522]  [MGI Ref ID J:125853]

O'Brien AD; Weinstein DA; Soliman MY; Rosenstreich DL. 1985. Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice. J Immunol 134(5):2820-3. [PubMed: 3884708]  [MGI Ref ID J:7783]

Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y. 2006. Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice. Gut 55(1):105-13. [PubMed: 16118350]  [MGI Ref ID J:135830]

Ohashi K; Burkart V; Flohe S; Kolb H. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164(2):558-61. [PubMed: 10623794]  [MGI Ref ID J:59296]

Oliveira AC; Peixoto JR; de Arruda LB; Campos MA; Gazzinelli RT; Golenbock DT; Akira S; Previato JO; Mendonca-Previato L; Nobrega A; Bellio M. 2004. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 173(9):5688-96. [PubMed: 15494520]  [MGI Ref ID J:93767]

Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. [PubMed: 14970116]  [MGI Ref ID J:102150]

Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. [PubMed: 14978090]  [MGI Ref ID J:88229]

Patole PS; Schubert S; Hildinger K; Khandoga S; Khandoga A; Segerer S; Henger A; Kretzler M; Werner M; Krombach F; Schlondorff D; Anders HJ. 2005. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68(6):2582-7. [PubMed: 16316333]  [MGI Ref ID J:116903]

Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V. 2006. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107(9):3727-32. [PubMed: 16391018]  [MGI Ref ID J:132558]

Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. [PubMed: 9851930]  [MGI Ref ID J:51522]

Prince LS; Okoh VO; Moninger TO; Matalon S. 2004. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 287(5):L999-1006. [PubMed: 15475494]  [MGI Ref ID J:98217]

Qureshi ST; Gros P; Malo D. 1999. The Lps locus: genetic regulation of host responses to bacterial lipopolysaccharide Inflamm Res 48(12):613-20. [PubMed: 10669111]  [MGI Ref ID J:60495]

Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. [PubMed: 9989976]  [MGI Ref ID J:53343]

Rafi A; Nagarkatti M; Nagarkatti PS. 1997. Hyaluronate-CD44 interactions can induce murine B-cell activation. Blood 89(8):2901-8. [PubMed: 9108410]  [MGI Ref ID J:39824]

Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126]  [MGI Ref ID J:122735]

Reiling N; Holscher C; Fehrenbach A; Kroger S; Kirschning CJ; Goyert S; Ehlers S. 2002. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169(7):3480-4. [PubMed: 12244136]  [MGI Ref ID J:120386]

Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. [PubMed: 17389381]  [MGI Ref ID J:120373]

Rodriguez N; Wantia N; Fend F; Durr S; Wagner H; Miethke T. 2006. Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur J Immunol 36(5):1145-55. [PubMed: 16609927]  [MGI Ref ID J:114778]

Ruckdeschel K; Pfaffinger G; Haase R; Sing A; Weighardt H; Hacker G; Holzmann B; Heesemann J. 2004. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 173(5):3320-8. [PubMed: 15322195]  [MGI Ref ID J:92674]

Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. [PubMed: 16284241]  [MGI Ref ID J:108441]

Schaefer L; Babelova A; Kiss E; Hausser HJ; Baliova M; Krzyzankova M; Marsche G; Young MF; Mihalik D; Gotte M; Malle E; Schaefer RM; Grone HJ. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115(8):2223-2233. [PubMed: 16025156]  [MGI Ref ID J:100228]

Schilling JD; Mulvey MA; Vincent CD; Lorenz RG; Hultgren SJ. 2001. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol 166(2):1148-55. [PubMed: 11145696]  [MGI Ref ID J:66850]

Schurr JR; Young E; Byrne P; Steele C; Shellito JE; Kolls JK. 2005. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 73(1):532-45. [PubMed: 15618193]  [MGI Ref ID J:94838]

Segreti J; Gheusi G; Dantzer R; Kelley KW; Johnson RW. 1997. Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 61(6):873-8. [PubMed: 9177560]  [MGI Ref ID J:41154]

Sen G; Khan AQ; Chen Q; Snapper CM. 2005. In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands. J Immunol 175(5):3084-91. [PubMed: 16116197]  [MGI Ref ID J:113209]

Shen XD; Ke B; Zhai Y; Gao F; Busuttil RW; Cheng G; Kupiec-Weglinski JW. 2005. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5(8):1793-800. [PubMed: 15996225]  [MGI Ref ID J:114368]

Silver K; Ferry H; Crockford T; Cornall RJ. 2006. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol 36(6):1404-12. [PubMed: 16703567]  [MGI Ref ID J:115059]

Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. [PubMed: 11801671]  [MGI Ref ID J:127288]

Skidmore BJ; Chiller JM; Weigle WO; Riblet R; Watson J. 1976. Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med 143(1):143-50. [PubMed: 1244416]  [MGI Ref ID J:5593]

Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. [PubMed: 18300366]  [MGI Ref ID J:131552]

Spiller S; Dreher S; Meng G; Grabiec A; Thomas W; Hartung T; Pfeffer K; Hochrein H; Brade H; Bessler W; Wagner H; Kirschning CJ. 2007. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282(18):13190-8. [PubMed: 17353199]  [MGI Ref ID J:121930]

Steiner AA; Chakravarty S; Rudaya AY; Herkenham M; Romanovsky AA. 2006. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107(10):4000-2. [PubMed: 16403908]  [MGI Ref ID J:132740]

Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. [PubMed: 12625509]  [MGI Ref ID J:82325]

Suganami T; Mieda T; Itoh M; Shimoda Y; Kamei Y; Ogawa Y. 2007. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354(1):45-9. [PubMed: 17210129]  [MGI Ref ID J:117843]

Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479]  [MGI Ref ID J:35601]

Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. [PubMed: 359704]  [MGI Ref ID J:6043]

Takakuwa T; Knopf HP; Sing A; Carsetti R; Galanos C; Freudenberg MA. 1996. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol 26(11):2686-92. [PubMed: 8921956]  [MGI Ref ID J:36452]

Tang SC; Arumugam TV; Xu X; Cheng A; Mughal MR; Jo DG; Lathia JD; Siler DA; Chigurupati S; Ouyang X; Magnus T; Camandola S; Mattson MP. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104(34):13798-803. [PubMed: 17693552]  [MGI Ref ID J:124100]

Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. [PubMed: 15809417]  [MGI Ref ID J:97819]

Tavener SA; Long EM; Robbins SM; McRae KM; Van Remmen H; Kubes P. 2004. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95(7):700-7. [PubMed: 15358664]  [MGI Ref ID J:101491]

Taylor KR; Yamasaki K; Radek KA; Di Nardo A; Goodarzi H; Golenbock D; Beutler B; Gallo RL. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 282(25):18265-75. [PubMed: 17400552]  [MGI Ref ID J:123387]

Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. [PubMed: 12234819]  [MGI Ref ID J:108049]

Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. [PubMed: 17519423]  [MGI Ref ID J:126488]

Tsung A; Hoffman RA; Izuishi K; Critchlow ND; Nakao A; Chan MH; Lotze MT; Geller DA; Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 175(11):7661-8. [PubMed: 16301676]  [MGI Ref ID J:122164]

Tsung A; Klune JR; Zhang X; Jeyabalan G; Cao Z; Peng X; Stolz DB; Geller DA; Rosengart MR; Billiar TR. 2007. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204(12):2913-23. [PubMed: 17984303]  [MGI Ref ID J:128522]

Tsung A; Sahai R; Tanaka H; Nakao A; Fink MP; Lotze MT; Yang H; Li J; Tracey KJ; Geller DA; Billiar TR. 2005. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201(7):1135-43. [PubMed: 15795240]  [MGI Ref ID J:98036]

Tsung A; Zheng N; Jeyabalan G; Izuishi K; Klune JR; Geller DA; Lotze MT; Lu L; Billiar TR. 2007. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 81(1):119-28. [PubMed: 17062605]  [MGI Ref ID J:117230]

Vazquez-Torres A; Vallance BA; Bergman MA; Finlay BB; Cookson BT; Jones-Carson J; Fang FC. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol 172(10):6202-8. [PubMed: 15128808]  [MGI Ref ID J:89854]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. [PubMed: 10229796]  [MGI Ref ID J:54987]

Vogel SN; Wax JS; Perera PY; Padlan C; Potter M; Mock BA. 1994. Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene. Infect Immun 62(10):4454-9. [PubMed: 7927709]  [MGI Ref ID J:20449]

Vogl T; Tenbrock K; Ludwig S; Leukert N; Ehrhardt C; van Zoelen MA; Nacken W; Foell D; van der Poll T; Sorg C; Roth J. 2007. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-9. [PubMed: 17767165]  [MGI Ref ID J:125179]

Wang MJ; Jeng KC; Shih PC. 2000. Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice Cell Immunol 204(2):88-95. [PubMed: 11069716]  [MGI Ref ID J:65822]

Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. [PubMed: 11777976]  [MGI Ref ID J:73739]

Wang ZY; Yang D; Chen Q; Leifer CA; Segal DM; Su SB; Caspi RR; Howard ZO; Oppenheim JJ. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34(8):1115-24. [PubMed: 16863919]  [MGI Ref ID J:111901]

Warger T; Hilf N; Rechtsteiner G; Haselmayer P; Carrick DM; Jonuleit H; von Landenberg P; Rammensee HG; Nicchitta CV; Radsak MP; Schild H. 2006. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281(32):22545-53. [PubMed: 16754684]  [MGI Ref ID J:116459]

Watson J; Largen M; McAdam KP. 1978. Genetic control of endotoxic responses in mice. J Exp Med 147(1):39-49. [PubMed: 342667]  [MGI Ref ID J:5938]

Weighardt H; Kaiser-Moore S; Vabulas RM; Kirschning CJ; Wagner H; Holzmann B. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169(6):2823-7. [PubMed: 12218091]  [MGI Ref ID J:120435]

Whitaker SM; Colmenares M; Pestana KG; McMahon-Pratt D. 2008. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun 76(5):2149-56. [PubMed: 18299340]  [MGI Ref ID J:134478]

Wong PM; Kang A; Chen H; Yuan Q; Fan P; Sultzer BM; Kan YW; Chung SW. 1999. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc Natl Acad Sci U S A 96(20):11543-8. [PubMed: 10500213]  [MGI Ref ID J:57938]

Woods JP; Frelinger JA; Warrack G; Cannon JG. 1988. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56(8):1950-5. [PubMed: 3397181]  [MGI Ref ID J:27288]

Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. [PubMed: 10770809]  [MGI Ref ID J:61722]

Yang R; Murillo FM; Delannoy MJ; Blosser RL; Yutzy WH th; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2005. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174(12):7912-9. [PubMed: 15944297]  [MGI Ref ID J:100870]

Yang X; Murthy V; Schultz K; Tatro JB; Fitzgerald KA; Beasley D. 2006. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 291(5):H2334-43. [PubMed: 16782847]  [MGI Ref ID J:116310]

Yohe HC; O'Hara KA; Hunt JA; Kitzmiller TJ; Wood SG; Bement JL; Bement WJ; Szakacs JG; Wrighton SA; Jacobs JM; Kostrubsky V; Sinclair PR; Sinclair JF. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290(6):G1269-79. [PubMed: 16439473]  [MGI Ref ID J:111091]

Yoshida S; Goto Y; Miyamoto H; Fujio H; Mizuguchi Y. 1991. Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4(1):51-6. [PubMed: 1815711]  [MGI Ref ID J:657]

Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. [PubMed: 18199559]  [MGI Ref ID J:131415]

Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. [PubMed: 15485838]  [MGI Ref ID J:95155]

Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. [PubMed: 17053835]  [MGI Ref ID J:114985]

Zhang Y; Woodruff M; Zhang Y; Miao J; Hanley G; Stuart C; Zeng X; Prabhakar S; Moorman J; Zhao B; Yin D. 2008. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22. [PubMed: 18192029]  [MGI Ref ID J:131903]

Zhou Q; Desta T; Fenton M; Graves DT; Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun 73(2):935-43. [PubMed: 15664935]  [MGI Ref ID J:95773]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

 

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