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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain FVB/NJ Donor Strain B6;129S-Ccnd1tm1Wbg (129S2 derived D3 ES cell line) Donating Investigator The Jackson Laboratory, Appearance
albino
Related Genotype: Tyrc/TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Description
Mice homozygous for the targeted mutation develop to term but show growth retardation that is most pronounced by three weeks of age. The majority of mutant mice die early in life, often within the first month. Survivors continue to show lower than average weight and increased mortality. Mammary gland epithelial duct development is normal in virgin mutant mice. Mutant females that survive to adulthood are fertile, but mammary glands of pregnant mice show a dramatic impairment in the expansion of alveolar lobes and mice are unable to lactate. Steroid hormone levels are normal, and there is no apparent defect in estrogen receptor number, suggesting that cyclin D1 deficiency has an effect on the target tissue directly. Mutant mice demonstrate a neurological abnormality evidenced by limb retraction when lifted by their tails. The most severely affected animals remain in a clasped, flexed position for a few seconds after they have been returned to their cage. Retinal abnormalities include a dramatic reduction in cell numbers in all cell layers of the neural retina. This is due to the severely reduced ability of mutant retinal cell precursors to proliferate during embryonic development. The thickness of the inner plexiform layer is also reduced. The cells within the retina respond properly to light.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A 3700 bp EagI fragment of the mouse cyclin D1 gene, (5' to the first coding exon) was used in the targeting vector, and electoporated into D3 ES cells. Cyclin D1 heterozygous ES cells ere injected into C57BL/6 embryos, and the resulting chimeras were bred to B6 mice. The resulting cyclin D1 heterozygotes were bred to produce homozygous mice. The targeting vector deletes coding portions of exons I-III of the cyclin D1 gene and replaces them with the neomycin resistance gene. (Mam. Gland DB)
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Ccnd1tm1Wbg allele
002537 B6;129S2-Ccnd1tm1Wbg/J View Strains carrying Ccnd1tm1Wbg (1 strain)
005143 C3.B6-Tg(Fabp1-Ccnd1)4Rdb/J 004834 C57BL/6-Tg(Fabp1-Ccnd1)4Rdb/J
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Ccnd1tm1Wbg/Ccnd1tm1Wbg
involves: 129S2/SvPas
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:105045)
- about 25% die during the first month of life
- growth/size phenotype
- postnatal growth retardation (MGI Ref ID J:105045)
- by the third week of life, mutants were approximately 1/2 of the size of wildtype
- vision/eye phenotype
- abnormal eye electrophysiology (MGI Ref ID J:95994)
- reduced amplitudes of the a- and b-waves in retinas in response to a pulse of light, with a-waves corresponding to 15% of those seen in wildtype
- retinas respond to light with electroretinographic potentials corresponding to about 10% of those seen in wild-type
- retina hypoplasia (MGI Ref ID J:105045)
- all cell layers (outer nuclear, inner nuclear, and ganglion cell layers) of the retina were hypoplastic
- endocrine/exocrine gland phenotype
- abnormal lactation (MGI Ref ID J:95994)
- unable to breast-feed pups due to abnormal mammary tissue development
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:95994)
- underdeveloped mammary epithelial tree at the end of pregnancy
- reproductive system phenotype
- abnormal lactation (MGI Ref ID J:95994)
- unable to breast-feed pups due to abnormal mammary tissue development
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:95994)
- underdeveloped mammary epithelial tree at the end of pregnancy
- behavior/neurological phenotype
- limb grasping (MGI Ref ID J:95994)
- when lifted by tails, responded by rapidly retracting their limbs
Ccnd1tm1Wbg/Ccnd1tm1Wbg
involves: 129S2/SvPas * C57BL/6
- reproductive system phenotype
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:55690)
- mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy
- vision/eye phenotype
- abnormal eye electrophysiology (MGI Ref ID J:55690)
- have an essentially flat electroretinographic readout following light exposure
- retina hypoplasia (MGI Ref ID J:55690)
- hypoplastic and disorganized retina
- behavior/neurological phenotype
- limb grasping (MGI Ref ID J:55690)
- growth/size phenotype
- postnatal growth retardation (MGI Ref ID J:55690)
- about 2 fold smaller than wild-type littermates at 3 weeks of age
- endocrine/exocrine gland phenotype
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:55690)
- mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy
This mouse can be used to support research in many areas including:Ccnd1tm1Wbg related
Pde6brd1 relatedCancer Research
Genes Regulating Growth and Proliferation
Other
Cell Biology Research
Cell Cycle Regulation
Genes Regulating Growth and Proliferation
Developmental Biology Research
Eye Defects
Growth Defects
Postnatal Mortality
Sensorineural Research
Eye Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Ccnd1tm1Wbg | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Robert Weinberg | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | CD1-; cyclin D1-; | ||
| Mutation Made By | Robert Weinberg, Massachusetts Institute of Technology | ||
| Strain of Origin | 129S2/SvPas | ||
| ES Cell Line Name | D3 | ||
| ES Cell Line Strain | 129S2/SvPas | ||
| Gene Symbol and Name | Ccnd1, cyclin D1 | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | AI327039; BCL1; Cyl-1; D11S287E; PRAD1; U21B31; bcl-1; cD1; expressed sequence AI327039; | ||
| Molecular Note | A genomic fragment containing part of exon 1, exon 2 and exon 3 was replaced with a neomycin selection cassette. The deleted sequences encode the cyclin box domain thought to be required for protein activity. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no stable protein was made from this allele. [MGI Ref ID J:28419] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Ccndtm1Wbg, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Sicinski P; Donaher JL; Parker SB; Li T; Fazeli A; Gardner H; Haslam SZ; Bronson RT; Elledge SJ; Weinberg RA. 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82(4):621-30. [PubMed: 7664341] [MGI Ref ID J:28419]
Additional References
Bagui TK; Jackson RJ; Agrawal D; Pledger WJ. 2000. Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1) Mol Cell Biol 20(23):8748-57. [PubMed: 11073976] [MGI Ref ID J:65789]
Ccnd1tm1Wbg relatedCarthon BC; Neumann CA; Das M; Pawlyk B; Li T; Geng Y; Sicinski P. 2005. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol 25(3):1081-8. [PubMed: 15657434] [MGI Ref ID J:95994]
Chen B; Pollard JW. 2003. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol 17(7):1368-81. [PubMed: 12649329] [MGI Ref ID J:84144]
Chen Z; Duan RS; Zhu Y; Folkesson R; Albanese C; Winblad B; Zhu J. 2005. Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice. J Neurochem 92(5):1281-4. [PubMed: 15715677] [MGI Ref ID J:96799]
Ciemerych MA; Kenney AM; Sicinska E; Kalaszczynska I; Bronson RT; Rowitch DH; Gardner H; Sicinski P. 2002. Development of mice expressing a single D-type cyclin. Genes Dev 16(24):3277-89. [PubMed: 12502747] [MGI Ref ID J:80994]
Ciemerych MA; Yu Q; Szczepanska K; Sicinski P. 2008. CDK4 activity in mouse embryos expressing a single D-type cyclin. Int J Dev Biol 52(2-3):299-305. [PubMed: 18311721] [MGI Ref ID J:131845]
Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. [PubMed: 16582912] [MGI Ref ID J:112393]
Frech MS; Torre KM; Robinson GW; Furth PA. 2008. Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis. Oncogene 27(22):3186-93. [PubMed: 18071314] [MGI Ref ID J:135609]
Fu M; Rao M; Bouras T; Wang C; Wu K; Zhang X; Li Z; Yao TP; Pestell RG. 2005. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 280(17):16934-41. [PubMed: 15713663] [MGI Ref ID J:98783]
Geng Y; Whoriskey W; Park MY; Bronson RT; Medema RH; Li T; Weinberg RA; Sicinski P. 1999. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97(6):767-77. [PubMed: 10380928] [MGI Ref ID J:55690]
Geng Y; Yu Q; Sicinska E; Das M; Bronson RT; Sicinski P. 2001. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A 98(1):194-9. [PubMed: 11134518] [MGI Ref ID J:66707]
Glickstein SB; Monaghan JA; Koeller HB; Jones TK; Ross ME. 2009. Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci 29(30):9614-24. [PubMed: 19641124] [MGI Ref ID J:151321]
Glickstein SB; Moore H; Slowinska B; Racchumi J; Suh M; Chuhma N; Ross ME. 2007. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development 134(22):4083-93. [PubMed: 17965053] [MGI Ref ID J:127074]
Hulit J; Wang C; Li Z; Albanese C; Rao M; Di Vizio D; Shah S; Byers SW; Mahmood R; Augenlicht LH; Russell R; Pestell RG. 2004. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. (Erratum: v 25(1):523) Mol Cell Biol 24(17):7598-611. [PubMed: 15314168] [MGI Ref ID J:92787]
Kim HA; Pomeroy SL; Whoriskey W; Pawlitzky I; Benowitz LI; Sicinski P; Stiles CD; Roberts TM. 2000. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron 26(2):405-16. [PubMed: 10839359] [MGI Ref ID J:62564]
Kim NS; Kim HJ; Koo BK; Kwon MC; Kim YW; Cho Y; Yokota Y; Penninger JM; Kong YY. 2006. Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol 26(3):1002-13. [PubMed: 16428453] [MGI Ref ID J:105570]
Kowalczyk A; Filipkowski RK; Rylski M; Wilczynski GM; Konopacki FA; Jaworski J; Ciemerych MA; Sicinski P; Kaczmarek L. 2004. The critical role of cyclin D2 in adult neurogenesis. J Cell Biol 167(2):209-13. [PubMed: 15504908] [MGI Ref ID J:93310]
Kushner JA; Ciemerych MA; Sicinska E; Wartschow LM; Teta M; Long SY; Sicinski P; White MF. 2005. Cyclins D2 and D1 Are Essential for Postnatal Pancreatic {beta}-Cell Growth. Mol Cell Biol 25(9):3752-62. [PubMed: 15831479] [MGI Ref ID J:97628]
Landis MW; Pawlyk BS; Li T; Sicinski P; Hinds PW. 2006. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9(1):13-22. [PubMed: 16413468] [MGI Ref ID J:105045]
Li Z; Jiao X; Wang C; Ju X; Lu Y; Yuan L; Lisanti MP; Katiyar S; Pestell RG. 2006. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 66(20):9986-94. [PubMed: 17047061] [MGI Ref ID J:114959]
Li Z; Wang C; Jiao X; Lu Y; Fu M; Quong AA; Dye C; Yang J; Dai M; Ju X; Zhang X; Li A; Burbelo P; Stanley ER; Pestell RG. 2006. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 26(11):4240-56. [PubMed: 16705174] [MGI Ref ID J:109620]
Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579] [MGI Ref ID J:49399]
Pogoriler J; Millen K; Utset M; Du W. 2006. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development 133(19):3929-37. [PubMed: 16943274] [MGI Ref ID J:115956]
Rowlands TM; Pechenkina IV; Hatsell SJ; Pestell RG; Cowin P. 2003. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci U S A 100(20):11400-5. [PubMed: 13679587] [MGI Ref ID J:85819]
Sicinska E; Lee YM; Gits J; Shigematsu H; Yu Q; Rebel VI; Geng Y; Marshall CJ; Akashi K; Dorfman DM; Touw IP; Sicinski P. 2006. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol Cell Biol 26(21):8052-60. [PubMed: 16954383] [MGI Ref ID J:114672]
Takahashi M; Kojima M; Nakajima K; Suzuki-Migishima R; Takeuchi T. 2007. Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol 303(2):549-60. [PubMed: 17189626] [MGI Ref ID J:119194]
Tong W; Pollard JW. 2001. Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice. Mol Cell Biol 21(4):1319-28. [PubMed: 11158317] [MGI Ref ID J:67129]
Tsikitis M; Zhang Z; Edelman W; Zagzag D; Kalpana GV. 2005. Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A 102(34):12129-34. [PubMed: 16099835] [MGI Ref ID J:101185]
Wang C; Li Z; Lu Y; Du R; Katiyar S; Yang J; Fu M; Leader JE; Quong A; Novikoff PM; Pestell RG. 2006. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 103(31):11567-72. [PubMed: 16864783] [MGI Ref ID J:111799]
Wang C; Pattabiraman N; Zhou JN; Fu M; Sakamaki T; Albanese C; Li Z; Wu K; Hulit J; Neumeister P; Novikoff PM; Brownlee M; Scherer PE; Jones JG; Whitney KD; Donehower LA; Harris EL; Rohan T; Johns DC; Pestell RG. 2003. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 23(17):6159-73. [PubMed: 12917338] [MGI Ref ID J:85044]
Yang DP; Zhang DP; Mak KS; Bonder DE; Pomeroy SL; Kim HA. 2008. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci 38(1):80-8. [PubMed: 18374600] [MGI Ref ID J:136917]
Yu Q; Geng Y; Sicinski P. 2001. Specific protection against breast cancers by cyclin D1 ablation. Nature 411(6841):1017-21. [PubMed: 11429595] [MGI Ref ID J:70276]
Zhang M; Xie R; Hou W; Wang B; Shen R; Wang X; Wang Q; Zhu T; Jonason JH; Chen D. 2009. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 122(Pt 9):1382-9. [PubMed: 19351720] [MGI Ref ID J:150499]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, heterozygous mice can be bred with FVB/NJ. Expected coat color from breeding:Albino. Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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| Important Note | |
| This strain is homozygous for the retinal degeneration allele Pde6brd1. | |
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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