Strain Name:

FVB.129S2(B6)-Ccnd1tm1Wbg/J

Stock Number:

002935

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain FVB/NJ
Donor Strain B6;129S-Ccnd1tm1Wbg (129S2 derived D3 ES cell line)
 
Donating Investigator The Jackson Laboratory,  

Appearance
albino
Related Genotype: Tyrc/Tyrc

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Description
Mice homozygous for the targeted mutation develop to term but show growth retardation that is most pronounced by three weeks of age. The majority of mutant mice die early in life, often within the first month. Survivors continue to show lower than average weight and increased mortality. Mammary gland epithelial duct development is normal in virgin mutant mice. Mutant females that survive to adulthood are fertile, but mammary glands of pregnant mice show a dramatic impairment in the expansion of alveolar lobes and mice are unable to lactate. Steroid hormone levels are normal, and there is no apparent defect in estrogen receptor number, suggesting that cyclin D1 deficiency has an effect on the target tissue directly. Mutant mice demonstrate a neurological abnormality evidenced by limb retraction when lifted by their tails. The most severely affected animals remain in a clasped, flexed position for a few seconds after they have been returned to their cage. Retinal abnormalities include a dramatic reduction in cell numbers in all cell layers of the neural retina. This is due to the severely reduced ability of mutant retinal cell precursors to proliferate during embryonic development. The thickness of the inner plexiform layer is also reduced. The cells within the retina respond properly to light.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A 3700 bp EagI fragment of the mouse cyclin D1 gene, (5' to the first coding exon) was used in the targeting vector, and electoporated into D3 ES cells. Cyclin D1 heterozygous ES cells ere injected into C57BL/6 embryos, and the resulting chimeras were bred to B6 mice. The resulting cyclin D1 heterozygotes were bred to produce homozygous mice. The targeting vector deletes coding portions of exons I-III of the cyclin D1 gene and replaces them with the neomycin resistance gene. (Mam. Gland DB)

Control Information

  Control
   Wild-type from the colony
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ccnd1tm1Wbg allele
002537   B6;129S2-Ccnd1tm1Wbg/J
View Strains carrying   Ccnd1tm1Wbg     (1 strain)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
001547   C3Sn.Cg-Cm/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying   Pde6brd1     (74 strains)

Strains carrying other alleles of Ccnd1
005143   C3.B6-Tg(Fabp1-Ccnd1)4Rdb/J
004834   C57BL/6-Tg(Fabp1-Ccnd1)4Rdb/J
View Strains carrying other alleles of Ccnd1     (2 strains)

View Strains carrying other alleles of Pde6b     (10 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:105045)
    • about 25% die during the first month of life
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:105045)
    • by the third week of life, mutants were approximately 1/2 of the size of wildtype
  • vision/eye phenotype
  • abnormal eye electrophysiology (MGI Ref ID J:95994)
    • reduced amplitudes of the a- and b-waves in retinas in response to a pulse of light, with a-waves corresponding to 15% of those seen in wildtype
    • retinas respond to light with electroretinographic potentials corresponding to about 10% of those seen in wild-type
  • retina hypoplasia (MGI Ref ID J:105045)
    • all cell layers (outer nuclear, inner nuclear, and ganglion cell layers) of the retina were hypoplastic
  • endocrine/exocrine gland phenotype
  • abnormal lactation (MGI Ref ID J:95994)
    • unable to breast-feed pups due to abnormal mammary tissue development
  • abnormal mammary gland growth during pregnancy (MGI Ref ID J:95994)
    • underdeveloped mammary epithelial tree at the end of pregnancy
  • reproductive system phenotype
  • abnormal lactation (MGI Ref ID J:95994)
    • unable to breast-feed pups due to abnormal mammary tissue development
  • abnormal mammary gland growth during pregnancy (MGI Ref ID J:95994)
    • underdeveloped mammary epithelial tree at the end of pregnancy
  • behavior/neurological phenotype
  • limb grasping (MGI Ref ID J:95994)
    • when lifted by tails, responded by rapidly retracting their limbs

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas * C57BL/6
  • reproductive system phenotype
  • abnormal mammary gland growth during pregnancy (MGI Ref ID J:55690)
    • mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy
  • vision/eye phenotype
  • abnormal eye electrophysiology (MGI Ref ID J:55690)
    • have an essentially flat electroretinographic readout following light exposure
  • retina hypoplasia (MGI Ref ID J:55690)
    • hypoplastic and disorganized retina
  • behavior/neurological phenotype
  • limb grasping (MGI Ref ID J:55690)
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:55690)
    • about 2 fold smaller than wild-type littermates at 3 weeks of age
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland growth during pregnancy (MGI Ref ID J:55690)
    • mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ccnd1tm1Wbg related

Cancer Research
Genes Regulating Growth and Proliferation
Other

Cell Biology Research
Cell Cycle Regulation
Genes Regulating Growth and Proliferation

Developmental Biology Research
Eye Defects
Growth Defects
Postnatal Mortality

Sensorineural Research
Eye Defects

Pde6brd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Ccnd1tm1Wbg
Allele Name targeted mutation 1, Robert Weinberg
Allele Type Targeted (knock-out)
Common Name(s) CD1-; cyclin D1-;
Mutation Made By Robert Weinberg,   Massachusetts Institute of Technology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Ccnd1, cyclin D1
Chromosome 7
Gene Common Name(s) AI327039; BCL1; Cyl-1; D11S287E; PRAD1; U21B31; bcl-1; cD1; expressed sequence AI327039;
Molecular Note A genomic fragment containing part of exon 1, exon 2 and exon 3 was replaced with a neomycin selection cassette. The deleted sequences encode the cyclin box domain thought to be required for protein activity. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no stable protein was made from this allele. [MGI Ref ID J:28419]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;

Genotyping

Genotyping Information

Genotyping Protocols

Ccndtm1Wbg, Separated PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Sicinski P; Donaher JL; Parker SB; Li T; Fazeli A; Gardner H; Haslam SZ; Bronson RT; Elledge SJ; Weinberg RA. 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82(4):621-30. [PubMed: 7664341]  [MGI Ref ID J:28419]

Additional References

Bagui TK; Jackson RJ; Agrawal D; Pledger WJ. 2000. Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1) Mol Cell Biol 20(23):8748-57. [PubMed: 11073976]  [MGI Ref ID J:65789]

Ccnd1tm1Wbg related

Carthon BC; Neumann CA; Das M; Pawlyk B; Li T; Geng Y; Sicinski P. 2005. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol 25(3):1081-8. [PubMed: 15657434]  [MGI Ref ID J:95994]

Chen B; Pollard JW. 2003. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol 17(7):1368-81. [PubMed: 12649329]  [MGI Ref ID J:84144]

Chen Z; Duan RS; Zhu Y; Folkesson R; Albanese C; Winblad B; Zhu J. 2005. Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice. J Neurochem 92(5):1281-4. [PubMed: 15715677]  [MGI Ref ID J:96799]

Ciemerych MA; Kenney AM; Sicinska E; Kalaszczynska I; Bronson RT; Rowitch DH; Gardner H; Sicinski P. 2002. Development of mice expressing a single D-type cyclin. Genes Dev 16(24):3277-89. [PubMed: 12502747]  [MGI Ref ID J:80994]

Ciemerych MA; Yu Q; Szczepanska K; Sicinski P. 2008. CDK4 activity in mouse embryos expressing a single D-type cyclin. Int J Dev Biol 52(2-3):299-305. [PubMed: 18311721]  [MGI Ref ID J:131845]

Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. [PubMed: 16582912]  [MGI Ref ID J:112393]

Frech MS; Torre KM; Robinson GW; Furth PA. 2008. Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis. Oncogene 27(22):3186-93. [PubMed: 18071314]  [MGI Ref ID J:135609]

Fu M; Rao M; Bouras T; Wang C; Wu K; Zhang X; Li Z; Yao TP; Pestell RG. 2005. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 280(17):16934-41. [PubMed: 15713663]  [MGI Ref ID J:98783]

Geng Y; Whoriskey W; Park MY; Bronson RT; Medema RH; Li T; Weinberg RA; Sicinski P. 1999. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97(6):767-77. [PubMed: 10380928]  [MGI Ref ID J:55690]

Geng Y; Yu Q; Sicinska E; Das M; Bronson RT; Sicinski P. 2001. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A 98(1):194-9. [PubMed: 11134518]  [MGI Ref ID J:66707]

Glickstein SB; Monaghan JA; Koeller HB; Jones TK; Ross ME. 2009. Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci 29(30):9614-24. [PubMed: 19641124]  [MGI Ref ID J:151321]

Glickstein SB; Moore H; Slowinska B; Racchumi J; Suh M; Chuhma N; Ross ME. 2007. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development 134(22):4083-93. [PubMed: 17965053]  [MGI Ref ID J:127074]

Hulit J; Wang C; Li Z; Albanese C; Rao M; Di Vizio D; Shah S; Byers SW; Mahmood R; Augenlicht LH; Russell R; Pestell RG. 2004. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. (Erratum: v 25(1):523) Mol Cell Biol 24(17):7598-611. [PubMed: 15314168]  [MGI Ref ID J:92787]

Kim HA; Pomeroy SL; Whoriskey W; Pawlitzky I; Benowitz LI; Sicinski P; Stiles CD; Roberts TM. 2000. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron 26(2):405-16. [PubMed: 10839359]  [MGI Ref ID J:62564]

Kim NS; Kim HJ; Koo BK; Kwon MC; Kim YW; Cho Y; Yokota Y; Penninger JM; Kong YY. 2006. Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol 26(3):1002-13. [PubMed: 16428453]  [MGI Ref ID J:105570]

Kowalczyk A; Filipkowski RK; Rylski M; Wilczynski GM; Konopacki FA; Jaworski J; Ciemerych MA; Sicinski P; Kaczmarek L. 2004. The critical role of cyclin D2 in adult neurogenesis. J Cell Biol 167(2):209-13. [PubMed: 15504908]  [MGI Ref ID J:93310]

Kushner JA; Ciemerych MA; Sicinska E; Wartschow LM; Teta M; Long SY; Sicinski P; White MF. 2005. Cyclins D2 and D1 Are Essential for Postnatal Pancreatic {beta}-Cell Growth. Mol Cell Biol 25(9):3752-62. [PubMed: 15831479]  [MGI Ref ID J:97628]

Landis MW; Pawlyk BS; Li T; Sicinski P; Hinds PW. 2006. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9(1):13-22. [PubMed: 16413468]  [MGI Ref ID J:105045]

Li Z; Jiao X; Wang C; Ju X; Lu Y; Yuan L; Lisanti MP; Katiyar S; Pestell RG. 2006. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 66(20):9986-94. [PubMed: 17047061]  [MGI Ref ID J:114959]

Li Z; Wang C; Jiao X; Lu Y; Fu M; Quong AA; Dye C; Yang J; Dai M; Ju X; Zhang X; Li A; Burbelo P; Stanley ER; Pestell RG. 2006. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 26(11):4240-56. [PubMed: 16705174]  [MGI Ref ID J:109620]

Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579]  [MGI Ref ID J:49399]

Pogoriler J; Millen K; Utset M; Du W. 2006. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development 133(19):3929-37. [PubMed: 16943274]  [MGI Ref ID J:115956]

Rowlands TM; Pechenkina IV; Hatsell SJ; Pestell RG; Cowin P. 2003. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci U S A 100(20):11400-5. [PubMed: 13679587]  [MGI Ref ID J:85819]

Sicinska E; Lee YM; Gits J; Shigematsu H; Yu Q; Rebel VI; Geng Y; Marshall CJ; Akashi K; Dorfman DM; Touw IP; Sicinski P. 2006. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol Cell Biol 26(21):8052-60. [PubMed: 16954383]  [MGI Ref ID J:114672]

Takahashi M; Kojima M; Nakajima K; Suzuki-Migishima R; Takeuchi T. 2007. Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol 303(2):549-60. [PubMed: 17189626]  [MGI Ref ID J:119194]

Tong W; Pollard JW. 2001. Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice. Mol Cell Biol 21(4):1319-28. [PubMed: 11158317]  [MGI Ref ID J:67129]

Tsikitis M; Zhang Z; Edelman W; Zagzag D; Kalpana GV. 2005. Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A 102(34):12129-34. [PubMed: 16099835]  [MGI Ref ID J:101185]

Wang C; Li Z; Lu Y; Du R; Katiyar S; Yang J; Fu M; Leader JE; Quong A; Novikoff PM; Pestell RG. 2006. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 103(31):11567-72. [PubMed: 16864783]  [MGI Ref ID J:111799]

Wang C; Pattabiraman N; Zhou JN; Fu M; Sakamaki T; Albanese C; Li Z; Wu K; Hulit J; Neumeister P; Novikoff PM; Brownlee M; Scherer PE; Jones JG; Whitney KD; Donehower LA; Harris EL; Rohan T; Johns DC; Pestell RG. 2003. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 23(17):6159-73. [PubMed: 12917338]  [MGI Ref ID J:85044]

Yang DP; Zhang DP; Mak KS; Bonder DE; Pomeroy SL; Kim HA. 2008. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci 38(1):80-8. [PubMed: 18374600]  [MGI Ref ID J:136917]

Yu Q; Geng Y; Sicinski P. 2001. Specific protection against breast cancers by cyclin D1 ablation. Nature 411(6841):1017-21. [PubMed: 11429595]  [MGI Ref ID J:70276]

Zhang M; Xie R; Hou W; Wang B; Shen R; Wang X; Wang Q; Zhu T; Jonason JH; Chen D. 2009. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 122(Pt 9):1382-9. [PubMed: 19351720]  [MGI Ref ID J:150499]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, heterozygous mice can be bred with FVB/NJ. Expected coat color from breeding:Albino.
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • This strain is included in the Induced Mutant Resource Colony collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Control Information

  Control
   Wild-type from the colony
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(3.12)