Strain Name:

C.B6-Klra8Cmv1-r/UwaJ

Stock Number:

002936

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Other products are available, see Purchasing Information for Cryopreserved Embryos

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain C57BL/6

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
This BALB/c congenic carries C57BL/6 alleles for loci in the natural killer cell gene complex (NKC) on mouse chromosome 6. The region contains Klra (formerly Ly49), Klrb1 (formerly Ly55) and Klra8. This strain is useful in tumor models involving NK cell regulation and the expression of NK1.1 on BALB/c background. It plays a role in elucidating the contribution of the NKC region in controlling infectious agents.

Development
Made from donor strain C57BL/6 and recipient strain BALB/c. At each generation mice used in next backcross were screened for Cmvlr allele. After 10 generations of backcrossing, brother x sister matings were initiated to generate homozygous individuals. Representative mice from the colony maintained by Scalzo at University of Western Australia were sent to his collaborator Yokoyama at Washington University in St. Louis. The Yokoyama colony is the source of TJL mice.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Klra8Cmv1-r allele
025661   C.Cg-Klrk1tm1Dhr Klra8Cmv1-r/DhrJ
View Strains carrying   Klra8Cmv1-r     (1 strain)

Strains carrying other alleles of Klra8
008633   B6.BXD8-Klra8Cmv1-del/WumJ
000084   BXD8/TyJ
View Strains carrying other alleles of Klra8     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Klra8Cmv1-r/Klra8Cmv1-r

        C.B6-Klra8Cmv1-r
  • mortality/aging
  • increased susceptibility to infection induced morbidity/mortality
    • about 40% of mice die within 10 days of infection with the P. berghei parasite compared to less than 15% lethality for BALB/c mice and 100% lethality for C57BL/6 mice   (MGI Ref ID J:97203)
  • immune system phenotype
  • decreased IgG level
    • total and parasite specific IgG levels are significantly less thanin BALB/c controls starting one week after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG1 level
      • parasite specific IgG1 levels are significantly less than BALB/c controls starting one week after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG2a level
      • parasite specific levels are significantly less than BALB/c controls between 3 and 10 days after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG2b level
      • parasite specific levelsof IgG2b are significantly less than in BALB/c controls starting one week after infection with P. berghei with 8-fold differences occurring two weeks after infection   (MGI Ref ID J:97203)
    • decreased IgG3 level
      • parasite specific IgG3 levels are significantly less than BALB/c controls starting 10 days after infection with P. berghei   (MGI Ref ID J:97203)
  • decreased interleukin-4 secretion
    • splenocytes from malaria-infected mice produce much less IL-4 upon encounter with parasite antigens compared to BALB/c controls   (MGI Ref ID J:97203)
  • decreased susceptibility to viral infection
    • mice have a 1000-fold lower viral titer in the spleen three days after CMV infection compared to BALB/c controls   (MGI Ref ID J:79093)
    • this resistance to CMV infection is similar to what is observed in C57BL/6 mice   (MGI Ref ID J:79093)
    • mice have low titers of murine cytomegalovirus (CMV) in their spleens 2 to 6 days after infection compared to control BALB/c mice that have 1000-fold higher titers   (MGI Ref ID J:22486)
    • this resistance is mediated by natural killer (NK) cells as demonstrated by a lack of resistance to CMV when NK cells are depleted by antibody treatment   (MGI Ref ID J:22486)
  • increased IgM level
    • both parasite specific and total levels of IgM remain elevated 8-14 days after infection with P. berghei while IgM levels decrease in BALB/c controls   (MGI Ref ID J:97203)
  • increased circulating interferon-gamma level
    • circulating IFN-gamma levels are significantly higher 3, 5, and 7 days after P. berghei infection compared to BALB/c control mice   (MGI Ref ID J:97203)
  • increased susceptibility to infection induced morbidity/mortality
    • about 40% of mice die within 10 days of infection with the P. berghei parasite compared to less than 15% lethality for BALB/c mice and 100% lethality for C57BL/6 mice   (MGI Ref ID J:97203)
  • increased susceptibility to parasitic infection
    • mice have more severe vascular occlusion in the brain caused by parasitized erythrocytes and macrophages than in control BALB/c mice seven days after infection   (MGI Ref ID J:97203)
    • pulmonary edema is more severe 7-10 days after P. berghei infection than in BALB/c control   (MGI Ref ID J:97203)
    • hemoglobin levels drop at a faster rate than in BALB/c controls after infection with P. berghei, reaching a level that is 20% of normal two weeks after infection   (MGI Ref ID J:97203)
  • homeostasis/metabolism phenotype
  • decreased transforming growth factor level
    • TGF-beta levels are slightly lower than BALB/c controls two weeks after P. berghei infection   (MGI Ref ID J:97203)
  • increased circulating interferon-gamma level
    • circulating IFN-gamma levels are significantly higher 3, 5, and 7 days after P. berghei infection compared to BALB/c control mice   (MGI Ref ID J:97203)
  • hematopoietic system phenotype
  • decreased IgG level
    • total and parasite specific IgG levels are significantly less thanin BALB/c controls starting one week after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG1 level
      • parasite specific IgG1 levels are significantly less than BALB/c controls starting one week after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG2a level
      • parasite specific levels are significantly less than BALB/c controls between 3 and 10 days after infection with P. berghei   (MGI Ref ID J:97203)
    • decreased IgG2b level
      • parasite specific levelsof IgG2b are significantly less than in BALB/c controls starting one week after infection with P. berghei with 8-fold differences occurring two weeks after infection   (MGI Ref ID J:97203)
    • decreased IgG3 level
      • parasite specific IgG3 levels are significantly less than BALB/c controls starting 10 days after infection with P. berghei   (MGI Ref ID J:97203)
  • increased IgM level
    • both parasite specific and total levels of IgM remain elevated 8-14 days after infection with P. berghei while IgM levels decrease in BALB/c controls   (MGI Ref ID J:97203)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Klra8Cmv1-r related

Research Tools
Immunology, Inflammation and Autoimmunity Research
      congenic for CMV1 and NK cell gene complex region

Virology Research
Linkage Testing Stock

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Klra8Cmv1-r
Allele Name cytomegalovirus resistance 1, resistant
Allele Type Not Applicable
Common Name(s) Cmv1r;
Strain of OriginC57BL/6
Gene Symbol and Name Klra8, killer cell lectin-like receptor, subfamily A, member 8
Chromosome 6
Gene Common Name(s) Cmv-1; Cmv1; Ly49h; Ly49i6; Ly49u129; cytomegalovirus resistance 1; lymphocyte antigen 49 complex, locus H;
Molecular Note Mapping experiments confirmed that the C57BL/6 strain contained the Klra8 gene, and expression of Klra8 correlated with the resistant phenotype. [MGI Ref ID J:79093]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Scalzo AA; Lyons PA; Fitzgerald NA; Forbes CA; Shellam GR. 1995. The BALB.B6-Cmv1r mouse: a strain congenic for Cmv1 and the NK gene complex. Immunogenetics 41(2-3):148-51. [PubMed: 7806288]  [MGI Ref ID J:22486]

Additional References

Lundberg P; Welander P; Openshaw H; Nalbandian C; Edwards C; Moldawer L; Cantin E. 2003. A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice. J Virol 77(21):11661-73. [PubMed: 14557652]  [MGI Ref ID J:86189]

Scalzo AA; Fitzgerald NA; Wallace CR; Gibbons AE; Smart YC; Burton RC; Shellam GR. 1992. The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol 149(2):581-9. [PubMed: 1378069]  [MGI Ref ID J:1426]

Klra8Cmv1-r related

Andrews DM; Estcourt MJ; Andoniou CE; Wikstrom ME; Khong A; Voigt V; Fleming P; Tabarias H; Hill GR; van der Most RG; Scalzo AA; Smyth MJ; Degli-Esposti MA. 2010. Innate immunity defines the capacity of antiviral T cells to limit persistent infection. J Exp Med 207(6):1333-43. [PubMed: 20513749]  [MGI Ref ID J:163415]

Brown MG; Dokun AO; Heusel JW; Smith HR; Beckman DL; Blattenberger EA; Dubbelde CE; Stone LR; Scalzo AA; Yokoyama WM. 2001. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292(5518):934-7. [PubMed: 11340207]  [MGI Ref ID J:131208]

Dickgreber N; Farrand KJ; van Panhuys N; Knight DA; McKee SJ; Chong ML; Miranda-Hernandez S; Baxter AG; Locksley RM; Le Gros G; Hermans IF. 2012. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol 92(5):999-1009. [PubMed: 22941735]  [MGI Ref ID J:190015]

Hansen DS; Evans KJ; D'Ombrain MC; Bernard NJ; Sexton AC; Buckingham L; Scalzo AA; Schofield L. 2005. The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA. Infect Immun 73(4):2288-97. [PubMed: 15784573]  [MGI Ref ID J:97203]

Hansen DS; Siomos MA; Buckingham L; Scalzo AA; Schofield L. 2003. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18(3):391-402. [PubMed: 12648456]  [MGI Ref ID J:82493]

Iizuka K; Scalzo AA; Xian H; Yokoyama WM. 2008. Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol 180(5):3260-7. [PubMed: 18292550]  [MGI Ref ID J:131556]

Lee SH; Girard S; Macina D; Busa M; Zafer A; Belouchi A; Gros P; Vidal SM. 2001. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet 28(1):42-5. [PubMed: 11326273]  [MGI Ref ID J:79093]

Lee SH; Gitas J; Zafer A; Lepage P; Hudson TJ; Belouchi A; Vidal SM. 2001. Haplotype mapping indicates two independent origins for the Cmv1s susceptibility allele to cytomegalovirus infection and refines its localization within the Ly49 cluster. Immunogenetics 53(6):501-5. [PubMed: 11685461]  [MGI Ref ID J:72437]

Lee SH; Zafer A; de Repentigny Y; Kothary R; Tremblay ML; Gros P; Duplay P; Webb JR; Vidal SM. 2003. Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med 197(4):515-26. [PubMed: 12591908]  [MGI Ref ID J:81966]

Robbins SH; Bessou G; Cornillon A; Zucchini N; Rupp B; Ruzsics Z; Sacher T; Tomasello E; Vivier E; Koszinowski UH; Dalod M. 2007. Natural killer cells promote early CD8 T cell responses against cytomegalovirus. PLoS Pathog 3(8):e123. [PubMed: 17722980]  [MGI Ref ID J:162724]

Saito TI; Li HW; Sykes M. 2010. Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. J Immunol 185(4):2099-105. [PubMed: 20631307]  [MGI Ref ID J:162553]

Scalzo AA; Fitzgerald NA; Simmons A; La Vista AB; Shellam GR. 1990. Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen. J Exp Med 171(5):1469-83. [PubMed: 2159050]  [MGI Ref ID J:10460]

Scalzo AA; Manzur M; Forbes CA; Brown MG; Shellam GR. 2005. NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations. Immunol Cell Biol 83(2):144-9. [PubMed: 15748210]  [MGI Ref ID J:96887]

Scalzo AA; Wheat R; Dubbelde C; Stone L; Clark P; Du Y; Dong N; Stoll J; Yokoyama WM; Brown MG. 2003. Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus. Immunogenetics 55(6):370-8. [PubMed: 12920489]  [MGI Ref ID J:86300]

Sheppard S; Triulzi C; Ardolino M; Serna D; Zhang L; Raulet DH; Guerra N. 2013. Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire. Blood 121(25):5025-33. [PubMed: 23649470]  [MGI Ref ID J:198931]

Taherzadeh Z; VanBavel E; de Vos J; Matlung HL; van Montfrans G; Brewster LM; Seghers L; Quax PH; Bakker EN. 2010. Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex. Am J Physiol Heart Circ Physiol 298(4):H1273-82. [PubMed: 20154263]  [MGI Ref ID J:158596]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)