Strain Name:

B6NTac.Cg-H2-Ab1tm1Gru Tg(Ab1TL)1Gru/J

Stock Number:


Order this mouse


Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/6Tac-H2-Ab1tm1Gru Tg(Ab1TL)1Gru/J    (Changed: 19-OCT-07 )
Type Congenic; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse

Hemizygous transgenic mice expressing only truncated class II A beta molecules lacking the 13 membrane distal residues were generated to address the role of class II cytoplasmic domains in physiological, non-transformed APC and in vivo immune responses. CD4+ T cell development and immune responses to conventional protein antigens, parasitic infections and skin grafts were indistinguishable between control and transgenic mice in vivo. However, in vitro, APC from transgenic mice poorly stimulate T cell hybridomas and wild-type in vivo-primed T cells. Class II-mediated induction of B7-1 expression and homotypic aggregation were not diminished in transgenic B cells, suggesting that both cAMP and tyrosine kinase signaling pathways remain intact despite truncation of the A beta cytoplasmic domain.

Control Information

   Wild-type from the colony
   000664 C57BL/6J (approximate)
  Considerations for Choosing Controls

Related Strains

View Strains carrying   H2-Ab1tm1Gru     (7 strains)

View Strains carrying other alleles of H2-Ab1     (9 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Celiac Disease, Susceptibility to, 1; CELIAC1   (HLA-DQB1)
Creutzfeldt-Jakob Disease; CJD   (HLA-DQB1)
Multiple Sclerosis, Susceptibility To; MS   (HLA-DQB1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

H2-Ab1tm1Gru/H2-Ab1tm1Gru Tg(Ab1TL)1Gru/0

        B6.Cg-H2-Ab1tm1Gru Tg(Ab1TL)1Gru
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell differentiation
    • CD4+ T cell development is normal in these mice   (MGI Ref ID J:91341)
  • abnormal macrophage antigen presentation
    • peritoneal macrophages have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide   (MGI Ref ID J:91341)
  • immune system phenotype
  • abnormal CD4-positive T cell differentiation
    • CD4+ T cell development is normal in these mice   (MGI Ref ID J:91341)
  • abnormal professional antigen presenting cell physiology
    • splenic APC have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide   (MGI Ref ID J:91341)
    • LPS-induced blasts and peritoneal macrophages are also poor stimulators   (MGI Ref ID J:91341)
    • these splenic APC are also poor stimulators for freshly isolated T cells collected from immunized mice   (MGI Ref ID J:91341)
    • chemically fixed APC are also poor stimulators to T cell hybridomas when cognate peptide is loaded under neutral pH conditions   (MGI Ref ID J:91341)
    • however, chemically fixed APC are excellent stimulators when cognate peptide is loaded under acidic (pH 5) conditions   (MGI Ref ID J:91341)
    • abnormal macrophage antigen presentation
      • peritoneal macrophages have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide   (MGI Ref ID J:91341)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

H2-Ab1tm1Gru related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol H2-Ab1tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) Abbeta-; Ab1tm1Gru; Abb-; Abbtm1; Abeta-; Abetab-; C2-; H2-Ab1-; H2-Ab1tm1Glm; I-Ab-; I-Abetab-; IAb-; IAbeta-; MHC class II-; MHC-II-deficient; [KO]Abb; mII-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name H2-Ab1, histocompatibility 2, class II antigen A, beta 1
Chromosome 17
Gene Common Name(s) A beta; AI845868; Abeta; Bb; CELIAC1; H-2Ab; H2-Ab; HLA-DQB; I-Ab; I-Abeta; I-region-associated antigen 2; IAb; IDDM1; Ia-2; Ia2; RT1.B; Rmcs1; expressed sequence AI845868; histocompatibility 2, class II antigen A, beta; response to metastatic cancers 1;
General Note Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)
Molecular Note A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. [MGI Ref ID J:74418]
Allele Symbol Tg(Ab1TL)1Gru
Allele Name transgene insertion 1, Michael J Grusby
Allele Type Transgenic (Inserted expressed sequence)
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of OriginC57BL/6
Expressed Gene H2-Ab1, histocompatibility 2, class II antigen A, beta 1, mouse, laboratory
Promoter H2-Ab1, histocompatibility 2, class II antigen A, beta 1, mouse, laboratory
Molecular Note This beta chain transgene expresses a truncated class II A beta molecules that lack the 13 membrane distal residues. Transgene expression was detected on B cells and stimulated macrophages, with the expression on B cells being about a log unit higher than endogenous expression. Immunoprecipitation of B cell lysates confirmed a truncated I-Abeta chain was being expressed. [MGI Ref ID J:91341]


Genotyping Information

Genotyping Protocols

H2-Ab1tm1Grualternate2, Separated PCR
Tg(Ab1TL)1Gru, Pyrosequencing
Tg(Ab1TL)1Gru, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Smiley ST; Laufer TM; Lo D; Glimcher LH; Grusby MJ. 1995. Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation. Int Immunol 7(4):665-77. [PubMed: 7547694]  [MGI Ref ID J:91341]

Additional References

H2-Ab1tm1Gru related

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Archambault AS; Carrero JA; Barnett LG; McGee NG; Sim J; Wright JO; Raabe T; Chen P; Ding H; Allenspach EJ; Dragatsis I; Laufer TM; Wu GF. 2013. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol 191(2):545-50. [PubMed: 23772037]  [MGI Ref ID J:204951]

Arias DA; McCarty N; Lu L; Maldonado RA; Shinohara ML; Cantor H. 2010. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A 107(6):2556-61. [PubMed: 20133794]  [MGI Ref ID J:157540]

Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011]  [MGI Ref ID J:88200]

Asada A; Zhao Y; Kondo S; Iwata M. 1998. Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation. J Biol Chem 273(43):28392-8. [PubMed: 9774466]  [MGI Ref ID J:115241]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Avci FY; Li X; Tsuji M; Kasper DL. 2011. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12):1602-9. [PubMed: 22101769]  [MGI Ref ID J:179822]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bansal-Pakala P; Halteman BS; Cheng MH; Croft M. 2004. Costimulation of CD8 T cell responses by OX40. J Immunol 172(8):4821-5. [PubMed: 15067059]  [MGI Ref ID J:89135]

Barnett LG; Simkins HM; Barnett BE; Korn LL; Johnson AL; Wherry EJ; Wu GF; Laufer TM. 2014. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J Immunol 192(8):3607-17. [PubMed: 24646739]  [MGI Ref ID J:209996]

Belz GT; Stevenson PG; Castrucci MR; Altman JD; Doherty PC. 2000. Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice. Proc Natl Acad Sci U S A 97(6):2725-30. [PubMed: 10694575]  [MGI Ref ID J:76987]

Belz GT; Wodarz D; Diaz G; Nowak MA; Doherty PC. 2002. Compromised Influenza Virus-Specific CD8(+)-T-Cell Memory in CD4(+)-T-Cell-Deficient Mice. J Virol 76(23):12388-93. [PubMed: 12414983]  [MGI Ref ID J:80033]

Benlagha K; Wei DG; Veiga J; Teyton L; Bendelac A. 2005. Characterization of the early stages of thymic NKT cell development. J Exp Med 202(4):485-92. [PubMed: 16087715]  [MGI Ref ID J:100557]

Bertram EM; Tafuri A; Shahinian A; Chan VS; Hunziker L; Recher M; Ohashi PS; Mak TW; Watts TH. 2002. Role of ICOS versus CD28 in antiviral immunity. Eur J Immunol 32(12):3376-85. [PubMed: 12432568]  [MGI Ref ID J:80851]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Beutner U; McLellan B; Kraus E; Huber BT. 1996. Lack of MMTV superantigen presentation in MHC class II-deficient mice. Cell Immunol 168(2):141-7. [PubMed: 8640859]  [MGI Ref ID J:110738]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Blache C; Adriouch S; Calbo S; Drouot L; Dulauroy S; Arnoult C; Le Corre S; Six A; Seman M; Boyer O. 2009. Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells. J Immunol 183(7):4182-6. [PubMed: 19767568]  [MGI Ref ID J:152754]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Borowski AB; Boesteanu AC; Mueller YM; Carafides C; Topham DJ; Altman JD; Jennings SR; Katsikis PD. 2007. Memory CD8+ T cells require CD28 costimulation. J Immunol 179(10):6494-503. [PubMed: 17982038]  [MGI Ref ID J:153868]

Boucheron N; Tschismarov R; Goeschl L; Moser MA; Lagger S; Sakaguchi S; Winter M; Lenz F; Vitko D; Breitwieser FP; Muller L; Hassan H; Bennett KL; Colinge J; Schreiner W; Egawa T; Taniuchi I; Matthias P; Seiser C; Ellmeier W. 2014. CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol 15(5):439-48. [PubMed: 24681565]  [MGI Ref ID J:209977]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

Brodeur JF; Li S; Damlaj O; Dave VP. 2009. Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon. Int Immunol 21(12):1317-27. [PubMed: 19819936]  [MGI Ref ID J:155472]

Broussard C; Fleischecker C; Horai R; Chetana M; Venegas AM; Sharp LL; Hedrick SM; Fowlkes BJ; Schwartzberg PL. 2006. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25(1):93-104. [PubMed: 16860760]  [MGI Ref ID J:113409]

Broxmeyer HE; Cooper S; Hangoc G; Chang CH. 2006. Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins. Exp Hematol 34(8):1078-84. [PubMed: 16863914]  [MGI Ref ID J:111903]

Byram SC; Carson MJ; DeBoy CA; Serpe CJ; Sanders VM; Jones KJ. 2004. CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation. J Neurosci 24(18):4333-9. [PubMed: 15128847]  [MGI Ref ID J:109784]

Byrom B; Barbet AF; Obwolo M; Mahan SM. 2000. CD8(+) T cell knockout mice are less susceptible to Cowdria ruminantium infection than athymic, CD4(+) T cell knockout, and normal C57BL/6 mice. Vet Parasitol 93(2):159-72. [PubMed: 11035234]  [MGI Ref ID J:106232]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci U S A 108(4):1561-6. [PubMed: 21220322]  [MGI Ref ID J:168246]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci U S A 108(4):1567-72. [PubMed: 21220309]  [MGI Ref ID J:168247]

Chakkalath HR; Theodos CM; Markowitz JS; Grusby MJ; Glimcher LH; Titus RG. 1995. Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis 171(5):1302-8. [PubMed: 7751707]  [MGI Ref ID J:113036]

Chamoto K; Wakita D; Narita Y; Zhang Y; Noguchi D; Ohnishi H; Iguchi T; Sakai T; Ikeda H; Nishimura T. 2006. An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy. Cancer Res 66(3):1809-17. [PubMed: 16452242]  [MGI Ref ID J:106666]

Chapes SK; Beharka AA. 1998. Salmonella infections in the absence of the major histocompatibility complex II. J Leukoc Biol 63(3):297-304. [PubMed: 9500516]  [MGI Ref ID J:119805]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chen W; Bennink JR; Morton PA; Yewdell JW. 2002. Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus. J Virol 76(20):10332-7. [PubMed: 12239309]  [MGI Ref ID J:126981]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

Cho KW; Morris DL; DelProposto JL; Geletka L; Zamarron B; Martinez-Santibanez G; Meyer KA; Singer K; O'Rourke RW; Lumeng CN. 2014. An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation. Cell Rep 9(2):605-17. [PubMed: 25310975]  [MGI Ref ID J:218539]

Chong MM; Simpson N; Ciofani M; Chen G; Collins A; Littman DR. 2010. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev 24(7):659-69. [PubMed: 20360383]  [MGI Ref ID J:158962]

Christensen JP; Cardin RD; Branum KC; Doherty PC. 1999. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell- deficient mice is mediated by IFN-gamma. Proc Natl Acad Sci U S A 96(9):5135-40. [PubMed: 10220431]  [MGI Ref ID J:54884]

Chu KK; Tippayawat P; Walker NJ; Harding SV; Atkins HS; Maillere B; Bancroft GJ; Lertmemongkolchai G; Altmann DM. 2011. CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. Eur J Immunol 41(1):107-15. [PubMed: 21182082]  [MGI Ref ID J:174658]

Clarke RL; Thiemann S; Refaeli Y; Werlen G; Potter TA. 2009. A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction. Eur J Immunol 39(6):1619-31. [PubMed: 19449311]  [MGI Ref ID J:149450]

Clausen BE; Waldburger JM; Schwenk F; Barras E; Mach B; Rajewsky K; Forster I; Reith W. 1998. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8(2):143-55. [PubMed: 9491996]  [MGI Ref ID J:67941]

Coles MC; Raulet DH. 1994. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9. [PubMed: 8006596]  [MGI Ref ID J:110734]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Crump AL; Grusby MJ; Glimcher LH; Cantor H. 1993. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A 90(22):10739-43. [PubMed: 7902569]  [MGI Ref ID J:111327]

Dave VP; Allman D; Keefe R; Hardy RR; Kappes DJ. 1998. HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A 95(14):8187-92. [PubMed: 9653162]  [MGI Ref ID J:48734]

Derrick SC; Evering TH; Sambandamurthy VK; Jalapathy KV; Hsu T; Chen B; Chen M; Russell RG; Junqueira-Kipnis AP; Orme IM; Porcelli SA; Jacobs WR Jr; Morris SL. 2007. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology 120(2):192-206. [PubMed: 17076705]  [MGI Ref ID J:122314]

Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258]  [MGI Ref ID J:172460]

Drutman SB; Trombetta ES. 2010. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol 185(4):2140-6. [PubMed: 20644175]  [MGI Ref ID J:162616]

Duffner UA; Maeda Y; Cooke KR; Reddy P; Ordemann R; Liu C; Ferrara JL; Teshima T. 2004. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol 172(12):7393-8. [PubMed: 15187116]  [MGI Ref ID J:90834]

Dutta M; Kraus ZJ; Gomez-Rodriguez J; Hwang SH; Cannons JL; Cheng J; Lee SY; Wiest DL; Wakeland EK; Schwartzberg PL. 2013. A role for ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol 190(5):2121-8. [PubMed: 23355739]  [MGI Ref ID J:193308]

Dutta M; Schwartzberg PL. 2012. Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108. J Immunol 188(7):3031-41. [PubMed: 22393150]  [MGI Ref ID J:183088]

Egawa T; Littman DR. 2008. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol 9(10):1131-9. [PubMed: 18776905]  [MGI Ref ID J:141144]

Egawa T; Tillman RE; Naoe Y; Taniuchi I; Littman DR. 2007. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 204(8):1945-57. [PubMed: 17646406]  [MGI Ref ID J:125959]

Ehst BD; Ingulli E; Jenkins MK. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3(11):1355-62. [PubMed: 14525595]  [MGI Ref ID J:91742]

Elliot JF. 2006. Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell-Personal Communication MGI Direct Data Submission :.  [MGI Ref ID J:113509]

Elliott JF; Liu J; Yuan ZN; Bautista-Lopez N; Wallbank SL; Suzuki K; Rayner D; Nation P; Robertson MA; Liu G; Kavanagh KM. 2003. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. Proc Natl Acad Sci U S A 100(23):13447-52. [PubMed: 14570980]  [MGI Ref ID J:86540]

Erman B; Alag AS; Dahle O; van Laethem F; Sarafova SD; Guinter TI; Sharrow SO; Grinberg A; Love PE; Singer A. 2006. Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. J Immunol 177(10):6613-25. [PubMed: 17082573]  [MGI Ref ID J:126026]

Erman B; Guinter TI; Singer A. 2004. Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation. J Exp Med 199(12):1719-24. [PubMed: 15210747]  [MGI Ref ID J:120401]

Fan L; Busser BW; Lifsted TQ; Lo D; Laufer TM. 2003. Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Natl Acad Sci U S A 100(6):3386-91. [PubMed: 12629221]  [MGI Ref ID J:82725]

Farr AR; Wu W; Choi B; Cavalcoli JD; Laouar Y. 2014. CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells. Proc Natl Acad Sci U S A 111(35):12841-6. [PubMed: 25143585]  [MGI Ref ID J:216401]

Felio K; Nguyen H; Dascher CC; Choi HJ; Li S; Zimmer MI; Colmone A; Moody DB; Brenner MB; Wang CR. 2009. CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. J Exp Med 206(11):2497-509. [PubMed: 19808251]  [MGI Ref ID J:154072]

Felix NJ; Brickey WJ; Griffiths R; Zhang J; Van Kaer L; Coffman T; Ting JP. 2000. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med 192(1):31-40. [PubMed: 10880524]  [MGI Ref ID J:63144]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. [PubMed: 10477611]  [MGI Ref ID J:119171]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

Fowlkes BJ; Robey EA. 2002. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J Immunol 169(4):1817-21. [PubMed: 12165504]  [MGI Ref ID J:120208]

Franco A; Tilly DA; Gramaglia I; Croft M; Cipolla L; Meldal M; Grey HM. 2000. Epitope affinity for MHC class I determines helper requirement for CTL priming. Nat Immunol 1(2):145-50. [PubMed: 11248807]  [MGI Ref ID J:118393]

Fyfe AI; Qiao JH; Lusis AJ. 1994. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 94(6):2516-20. [PubMed: 7989611]  [MGI Ref ID J:22138]

Galeazzi F; Lovato P; Blennerhassett PA; Haapala EM; Vallance BA; Collins SM. 2001. Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages. Am J Physiol Gastrointest Liver Physiol 281(1):G151-8. [PubMed: 11408267]  [MGI Ref ID J:107859]

Gallo EM; Winslow MM; Cante-Barrett K; Radermacher AN; Ho L; McGinnis L; Iritani B; Neilson JR; Crabtree GR. 2007. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature 450(7170):731-5. [PubMed: 18046413]  [MGI Ref ID J:130376]

Ganta RR; Cheng C; Wilkerson MJ; Chapes SK. 2004. Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice. Infect Immun 72(1):159-67. [PubMed: 14688093]  [MGI Ref ID J:87828]

Gebe JA; Yue BB; Unrath KA; Falk BA; Nepom GT. 2009. Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol 183(1):59-65. [PubMed: 19535636]  [MGI Ref ID J:150114]

Giese NA; Giese T; Morse HC 3rd. 1994. Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells. J Virol 68(9):5819-24. [PubMed: 7914549]  [MGI Ref ID J:19619]

Goldman KP; Park CS; Kim M; Matzinger P; Anderson CC. 2005. Thymic cortical epithelium induces self tolerance. Eur J Immunol 35(3):709-17. [PubMed: 15719367]  [MGI Ref ID J:96619]

Goncalves LA; Rodrigues-Duarte L; Rodo J; Vieira de Moraes L; Marques I; Penha-Goncalves C. 2013. TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Proc Natl Acad Sci U S A 110(48):19531-6. [PubMed: 24218563]  [MGI Ref ID J:202965]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Goto Y; Panea C; Nakato G; Cebula A; Lee C; Diez MG; Laufer TM; Ignatowicz L; Ivanov II. 2014. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40(4):594-607. [PubMed: 24684957]  [MGI Ref ID J:209969]

Gourley TS; Patel DR; Nickerson K; Hong SC; Chang CH. 2002. Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator. J Immunol 168(9):4414-9. [PubMed: 11970984]  [MGI Ref ID J:112146]

Greidinger EL; Zang Y; Jaimes K; Hogenmiller S; Nassiri M; Bejarano P; Barber GN; Hoffman RW. 2006. A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen. Arthritis Rheum 54(2):661-9. [PubMed: 16453294]  [MGI Ref ID J:136511]

Greidinger EL; Zang YJ; Jaimes K; Martinez L; Nassiri M; Hoffman RW. 2008. CD4(+) T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease. J Immunol 180(12):8444-54. [PubMed: 18523312]  [MGI Ref ID J:137131]

Grusby MJ; Auchincloss H Jr; Lee R; Johnson RS; Spencer JP; Zijlstra M; Jaenisch R; Papaioannou VE; Glimcher LH. 1993. Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci U S A 90(9):3913-7. [PubMed: 8483910]  [MGI Ref ID J:4743]

Grusby MJ; Johnson RS; Papaioannou VE; Glimcher LH. 1991. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253(5026):1417-20. [PubMed: 1910207]  [MGI Ref ID J:74418]

Hacker H; Chi L; Rehg JE; Redecke V. 2012. NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKalpha activation. J Immunol 188(9):4602-10. [PubMed: 22474019]  [MGI Ref ID J:188443]

Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. [PubMed: 12626535]  [MGI Ref ID J:126301]

Haks MC; Lefebvre JM; Lauritsen JP; Carleton M; Rhodes M; Miyazaki T; Kappes DJ; Wiest DL. 2005. Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity 22(5):595-606. [PubMed: 15894277]  [MGI Ref ID J:99103]

Hamilton SE; Wolkers MC; Schoenberger SP; Jameson SC. 2006. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol 7(5):475-81. [PubMed: 16604076]  [MGI Ref ID J:112558]

Han WG; Schuurhuis DH; Fu N; Camps M; van Duivenvoorde LM; Louis-Plence P; Franken KL; Huizinga TW; Melief CJ; Toes RE; Ossendorp F. 2009. DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg. Eur J Immunol 39(7):1765-1773. [PubMed: 19544486]  [MGI Ref ID J:150274]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933]  [MGI Ref ID J:140189]

Havari E; Lennon-Dumenil AM; Klein L; Neely D; Taylor JA; McInerney MF; Wucherpfennig KW; Lipes MA. 2004. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol 173(2):787-96. [PubMed: 15240665]  [MGI Ref ID J:91915]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

He X; Park K; Wang H; He X; Zhang Y; Hua X; Li Y; Kappes DJ. 2008. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28(3):346-58. [PubMed: 18342007]  [MGI Ref ID J:132996]

Hennion-Tscheltzoff O; Leboeuf D; Gauthier SD; Dupuis M; Assouline B; Gregoire A; Thiant S; Guimond M. 2013. TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy. Blood 121(23):4684-93. [PubMed: 23613523]  [MGI Ref ID J:198956]

Hervas-Stubbs S; Olivier A; Boisgerault F; Thieblemont N; Leclerc C. 2007. TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood 109(12):5318-26. [PubMed: 17339421]  [MGI Ref ID J:145420]

Hill JA; Bell DA; Brintnell W; Yue D; Wehrli B; Jevnikar AM; Lee DM; Hueber W; Robinson WH; Cairns E. 2008. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med 205(4):967-79. [PubMed: 18391064]  [MGI Ref ID J:133967]

Hinterberger M; Aichinger M; da Costa OP; Voehringer D; Hoffmann R; Klein L. 2010. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol 11(6):512-9. [PubMed: 20431619]  [MGI Ref ID J:160615]

Ho LH; Uehara T; Chen CC; Kubagawa H; Cooper MD. 1999. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci U S A 96(26):15086-90. [PubMed: 10611342]  [MGI Ref ID J:119839]

Honey K; Nakagawa T; Peters C; Rudensky A. 2002. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med 195(10):1349-58. [PubMed: 12021314]  [MGI Ref ID J:112070]

Horikawa M; Weimer ET; DiLillo DJ; Venturi GM; Spolski R; Leonard WJ; Heise MT; Tedder TF. 2013. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol 190(3):1158-68. [PubMed: 23275601]  [MGI Ref ID J:193035]

Hou S; Mo XY; Hyland L; Doherty PC. 1995. Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J Virol 69(3):1429-34. [PubMed: 7853474]  [MGI Ref ID J:111487]

Hsiao FC; Lin M; Tai A; Chen G; Huber BT. 2006. Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells. J Immunol 177(4):2056-60. [PubMed: 16887963]  [MGI Ref ID J:138376]

Hu HM; Winter H; Ma J; Croft M; Urba WJ; Fox BA. 2002. CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells. J Immunol 169(9):4897-904. [PubMed: 12391201]  [MGI Ref ID J:118780]

Hu HM; Winter H; Urba WJ; Fox BA. 2000. Divergent roles for CD4+ T cells in the priming and effector/memory phases of adoptive immunotherapy. J Immunol 165(8):4246-53. [PubMed: 11035058]  [MGI Ref ID J:119198]

Huang F; Kitaura Y; Jang I; Naramura M; Kole HH; Liu L; Qin H; Schlissel MS; Gu H. 2006. Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Immunity 25(4):571-81. [PubMed: 17045823]  [MGI Ref ID J:114877]

Humphreys IR; Loewendorf A; de Trez C; Schneider K; Benedict CA; Munks MW; Ware CF; Croft M. 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism. J Immunol 179(4):2195-202. [PubMed: 17675479]  [MGI Ref ID J:151228]

Ignatowicz L; Kappler J; Marrack P. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84(4):521-9. [PubMed: 8598039]  [MGI Ref ID J:58036]

Itano A; Salmon P; Kioussis D; Tolaini M; Corbella P; Robey E. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med 183(3):731-41. [PubMed: 8642277]  [MGI Ref ID J:90254]

Ito K; Bian HJ; Molina M; Han J; Magram J; Saar E; Belunis C; Bolin DR; Arceo R; Campbell R; Falcioni F; Vidovic D; Hammer J; Nagy ZA. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med 183(6):2635-44. [PubMed: 8676084]  [MGI Ref ID J:109908]

Jevnikar AM; Grusby MJ; Glimcher LH. 1994. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med 179(4):1137-43. [PubMed: 7908320]  [MGI Ref ID J:17444]

Johnston PF; Gerding DN; Knight KL. 2014. Protection from Clostridium difficile infection in CD4 T Cell- and polymeric immunoglobulin receptor-deficient mice. Infect Immun 82(2):522-31. [PubMed: 24478068]  [MGI Ref ID J:209815]

Jones-Mason ME; Zhao X; Kappes D; Lasorella A; Iavarone A; Zhuang Y. 2012. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348-61. [PubMed: 22425249]  [MGI Ref ID J:187334]

Jun JE; Yang M; Chen H; Chakraborty AK; Roose JP. 2013. Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS. Mol Cell Biol 33(12):2470-84. [PubMed: 23589333]  [MGI Ref ID J:204491]

Kawamoto N; Ohnishi H; Kondo N; Strominger JL. 2013. The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers. Int Immunol 25(1):53-65. [PubMed: 22968996]  [MGI Ref ID J:197126]

Keefe R; Dave V; Allman D; Wiest D; Kappes DJ. 1999. Regulation of lineage commitment distinct from positive selection. Science 286(5442):1149-53. [PubMed: 10550051]  [MGI Ref ID J:124533]

Kemball CC; Pack CD; Guay HM; Li ZN; Steinhauer DA; Szomolanyi-Tsuda E; Lukacher AE. 2007. The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. J Immunol 179(2):1113-21. [PubMed: 17617604]  [MGI Ref ID J:149396]

Kim EY; Battaile JT; Patel AC; You Y; Agapov E; Grayson MH; Benoit LA; Byers DE; Alevy Y; Tucker J; Swanson S; Tidwell R; Tyner JW; Morton JD; Castro M; Polineni D; Patterson GA; Schwendener RA; Allard JD; Peltz G; Holtzman MJ. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14(6):633-40. [PubMed: 18488036]  [MGI Ref ID J:136947]

Kim JS; Smith-Garvin JE; Koretzky GA; Jordan MS. 2011. The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells. J Exp Med 208(11):2201-7. [PubMed: 21948082]  [MGI Ref ID J:178875]

Kim KD; Zhao J; Auh S; Yang X; Du P; Tang H; Fu YX. 2007. Adaptive immune cells temper initial innate responses. Nat Med 13(10):1248-52. [PubMed: 17891146]  [MGI Ref ID J:129989]

Kish DD; Gorbachev AV; Fairchild RL. 2007. Regulatory function of CD4+CD25+ T cells from Class II MHC-deficient mice in contact hypersensitivity responses. J Leukoc Biol 82(1):85-92. [PubMed: 17412917]  [MGI Ref ID J:122667]

Kovalovsky D; Yu Y; Dose M; Emmanouilidou A; Konstantinou T; Germar K; Aghajani K; Guo Z; Mandal M; Gounari F. 2009. Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol 183(6):3873-84. [PubMed: 19717519]  [MGI Ref ID J:152395]

Koyama M; Hashimoto D; Aoyama K; Matsuoka K; Karube K; Niiro H; Harada M; Tanimoto M; Akashi K; Teshima T. 2009. Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood 113(9):2088-95. [PubMed: 19144988]  [MGI Ref ID J:146164]

Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276]  [MGI Ref ID J:119348]

Kuwano Y; Prazma CM; Yazawa N; Watanabe R; Ishiura N; Kumanogoh A; Okochi H; Tamaki K; Fujimoto M; Tedder TF. 2007. CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. Int Immunol 19(8):977-92. [PubMed: 17804692]  [MGI Ref ID J:124890]

Laky K; Fowlkes BJ. 2007. Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med 204(9):2115-29. [PubMed: 17698590]  [MGI Ref ID J:126088]

Lawson VJ; Weston K; Maurice D. 2010. Early growth response 2 regulates the survival of thymocytes during positive selection. Eur J Immunol 40(1):232-41. [PubMed: 19877014]  [MGI Ref ID J:155694]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee HK; Mattei LM; Steinberg BE; Alberts P; Lee YH; Chervonsky A; Mizushima N; Grinstein S; Iwasaki A. 2010. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 32(2):227-39. [PubMed: 20171125]  [MGI Ref ID J:157911]

Lemessurier K; Hacker H; Tuomanen E; Redecke V. 2010. Inhibition of T Cells Provides Protection against Early Invasive Pneumococcal Disease. Infect Immun 78(12):5287-94. [PubMed: 20855509]  [MGI Ref ID J:165973]

Lemos MP; Esquivel F; Scott P; Laufer TM. 2004. MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major. J Exp Med 199(5):725-30. [PubMed: 14993255]  [MGI Ref ID J:123991]

Lesage S; Steff AM; Philippoussis F; Page M; Trop S; Mateo V ; Hugo P. 1997. CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway. J Immunol 159(10):4762-71. [PubMed: 9366400]  [MGI Ref ID J:44075]

Lesourne R; Uehara S; Lee J; Song KD; Li L; Pinkhasov J; Zhang Y; Weng NP; Wildt KF; Wang L; Bosselut R; Love PE. 2009. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol 10(8):840-7. [PubMed: 19597498]  [MGI Ref ID J:151075]

Li W; Sofi MH; Yeh N; Sehra S; McCarthy BP; Patel DR; Brutkiewicz RR; Kaplan MH; Chang CH. 2007. Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med 204(9):2145-57. [PubMed: 17724129]  [MGI Ref ID J:126084]

Lin JS; Yang CW; Wang DW; Wu-Hsieh BA. 2005. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J Immunol 174(10):6282-91. [PubMed: 15879127]  [MGI Ref ID J:109987]

Linette GP; Grusby MJ; Hedrick SM; Hansen TH; Glimcher LH; Korsmeyer SJ. 1994. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1(3):197-205. [PubMed: 7889408]  [MGI Ref ID J:81144]

Liu H; Andreansky S; Diaz G; Hogg T; Doherty PC. 2002. Reduced Functional Capacity of CD8(+) T Cells Expanded by Post-Exposure Vaccination of gamma-Herpesvirus-Infected CD4-Deficient Mice. J Immunol 168(7):3477-83. [PubMed: 11907108]  [MGI Ref ID J:75576]

Liu J; Purdy LE; Rabinovitch S; Jevnikar AM; Elliott JF. 1999. Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. Diabetes 48(3):469-77. [PubMed: 10078545]  [MGI Ref ID J:87013]

Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105(11):1623-30. [PubMed: 10841521]  [MGI Ref ID J:62762]

Lund FE; Hollifield M; Schuer K; Lines JL; Randall TD; Garvy BA. 2006. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol 176(10):6147-54. [PubMed: 16670323]  [MGI Ref ID J:131763]

Maeda M; Shadeo A; MacFadyen AM; Takei F. 2004. CD1d-independent NKT cells in beta 2-microglobulin-deficient mice have hybrid phenotype and function of NK and T cells. J Immunol 172(10):6115-22. [PubMed: 15128797]  [MGI Ref ID J:132824]

Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996]  [MGI Ref ID J:107458]

Malley R; Srivastava A; Lipsitch M; Thompson CM; Watkins C; Tzianabos A; Anderson PW. 2006. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect Immun 74(4):2187-95. [PubMed: 16552049]  [MGI Ref ID J:107408]

Malley R; Trzcinski K; Srivastava A; Thompson CM; Anderson PW; Lipsitch M. 2005. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A 102(13):4848-53. [PubMed: 15781870]  [MGI Ref ID J:97363]

Mathewson N; Toubai T; Kapeles S; Sun Y; Oravecz-Wilson K; Tamaki H; Wang Y; Hou G; Sun Y; Reddy P. 2013. Neddylation plays an important role in the regulation of murine and human dendritic cell function. Blood 122(12):2062-73. [PubMed: 23863900]  [MGI Ref ID J:202233]

Matte CC; Liu J; Cormier J; Anderson BE; Athanasiadis I; Jain D; McNiff J; Shlomchik WD. 2004. Donor APCs are required for maximal GVHD but not for GVL. Nat Med 10(9):987-92. [PubMed: 15286785]  [MGI Ref ID J:92850]

Matte-Martone C; Liu J; Jain D; McNiff J; Shlomchik WD. 2008. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 111(7):3884-92. [PubMed: 18223170]  [MGI Ref ID J:133502]

Matza D; Lantner F; Bogoch Y; Flaishon L; Hershkoviz R; Shachar I. 2002. Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity. Proc Natl Acad Sci U S A 99(5):3018-23. [PubMed: 11867743]  [MGI Ref ID J:126904]

McCarthy MK; Levine RE; Procario MC; McDonnell PJ; Zhu L; Mancuso P; Crofford LJ; Aronoff DM; Weinberg JB. 2013. Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. PLoS One 8(10):e77628. [PubMed: 24147040]  [MGI Ref ID J:209103]

McGargill MA; Sharp LL; Bui JD; Hedrick SM; Calbo S. 2005. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol 175(2):656-64. [PubMed: 16002660]  [MGI Ref ID J:100674]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Melencio L; McKallip RJ; Guan H; Ramakrishnan R; Jain R; Nagarkatti PS; Nagarkatti M. 2006. Role of CD4+CD25+ T regulatory cells in IL-2-induced vascular leak. Int Immunol 18(10):1461-71. [PubMed: 16914509]  [MGI Ref ID J:112839]

Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647]  [MGI Ref ID J:110542]

Messaoudi I; Warner J; Nikolich-Zugich D; Fischer M; Nikolich-Zugich J. 2006. Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J Immunol 176(1):301-8. [PubMed: 16365422]  [MGI Ref ID J:126270]

Mizoguchi A; Mizoguchi E; Takedatsu H; Blumberg RS; Bhan AK. 2002. Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation. Immunity 16(2):219-30. [PubMed: 11869683]  [MGI Ref ID J:74718]

Mollo SB; Zajac AJ; Harrington LE. 2013. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol 191(12):6052-9. [PubMed: 24218454]  [MGI Ref ID J:207134]

Moran AE; Holzapfel KL; Xing Y; Cunningham NR; Maltzman JS; Punt J; Hogquist KA. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 208(6):1279-89. [PubMed: 21606508]  [MGI Ref ID J:172415]

Morris SC; Coffman RL; Finkelman FD. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells. J Immunol 160(7):3299-304. [PubMed: 9531287]  [MGI Ref ID J:111652]

Mukherjee R; Zhang Z; Zhong R; Yin ZQ; Roopenian DC; Jevnikar AM. 1996. Lupus nephritis in the absence of renal major histocompatibility complex class I and class II molecules. J Am Soc Nephrol 7(11):2445-52. [PubMed: 8959638]  [MGI Ref ID J:39693]

Muroi S; Naoe Y; Miyamoto C; Akiyama K; Ikawa T; Masuda K; Kawamoto H; Taniuchi I. 2008. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 9(10):1113-21. [PubMed: 18776907]  [MGI Ref ID J:141142]

Nagaraj S; Nelson A; Youn JI; Cheng P; Quiceno D; Gabrilovich DI. 2012. Antigen-Specific CD4+ T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC Class II Signaling. Cancer Res 72(4):928-38. [PubMed: 22237629]  [MGI Ref ID J:181201]

Nakabayashi T; Letterio JJ; Geiser AG; Kong L; Ogawa N; Zhao W ; Koike T ; Fernandes G ; Dang H ; Talal N. 1997. Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice. J Immunol 158(11):5527-35. [PubMed: 9164977]  [MGI Ref ID J:40637]

Ngai P; McCormick S; Small C; Zhang X; Zganiacz A; Aoki N; Xing Z. 2007. Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection. Infect Immun 75(5):2244-52. [PubMed: 17307945]  [MGI Ref ID J:121875]

Nishimura H; Washizu J; Naiki Y; Hara T; Fukui Y; Sasazuki T; Yoshikai Y. 1999. MHC class II-dependent NK1.1+ gammadelta T cells are induced in mice by Salmonella infection. J Immunol 162(3):1573-81. [PubMed: 9973415]  [MGI Ref ID J:124759]

Niu N; Laufer T; Homer RJ; Cohn L. 2009. Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. J Immunol 183(3):1523-7. [PubMed: 19596982]  [MGI Ref ID J:151587]

Noorchashm H; Lieu YK; Noorchashm N; Rostami SY; Greeley SA; Schlachterman A; Song HK; Noto LE; Jevnikar AM; Barker CF; Naji A. 1999. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol 163(2):743-50. [PubMed: 10395666]  [MGI Ref ID J:56160]

Olasz EB; Roh J; Yee CL; Arita K; Akiyama M; Shimizu H; Vogel JC; Yancey KB. 2007. Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice. J Invest Dermatol 127(12):2807-17. [PubMed: 17657247]  [MGI Ref ID J:127328]

Oliveira-dos-Santos AJ; Penninger JM; Rieker-Geley T; Matsumoto G; Mak TM; Wick G. 1998. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol 28(9):2882-92. [PubMed: 9754575]  [MGI Ref ID J:49877]

Pacholczyk R; Kern J; Singh N; Iwashima M; Kraj P; Ignatowicz L. 2007. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 27(3):493-504. [PubMed: 17869133]  [MGI Ref ID J:125322]

Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. [PubMed: 20118929]  [MGI Ref ID J:158504]

Park SH; Roark JH; Bendelac A. 1998. Tissue-specific recognition of mouse CD1 molecules. J Immunol 160(7):3128-34. [PubMed: 9531267]  [MGI Ref ID J:46614]

Pearce EL; Shedlock DJ; Shen H. 2004. Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice. J Immunol 173(4):2494-9. [PubMed: 15294964]  [MGI Ref ID J:92690]

Persaud SP; Parker CR; Lo WL; Weber KS; Allen PM. 2014. Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol 15(3):266-74. [PubMed: 24487322]  [MGI Ref ID J:209799]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Pobezinsky LA; Angelov GS; Tai X; Jeurling S; Van Laethem F; Feigenbaum L; Park JH; Singer A. 2012. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 13(6):569-78. [PubMed: 22544394]  [MGI Ref ID J:186451]

Polakos NK; Cornejo JC; Murray DA; Wright KO; Treanor JJ; Crispe IN; Topham DJ; Pierce RH. 2006. Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection. Am J Pathol 168(4):1169-78; quiz 1404-5. [PubMed: 16565492]  [MGI Ref ID J:107338]

Pope C; Kim SK; Marzo A; Masopust D; Williams K; Jiang J; Shen H; Lefrancois L. 2001. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol 166(5):3402-9. [PubMed: 11207297]  [MGI Ref ID J:126476]

Procopio DO; Almeida IC; Torrecilhas AC; Cardoso JE; Teyton L; Travassos LR; Bendelac A; Gazzinelli RT. 2002. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway. J Immunol 169(7):3926-33. [PubMed: 12244192]  [MGI Ref ID J:120405]

Purton JF; Tan JT; Rubinstein MP; Kim DM; Sprent J; Surh CD. 2007. Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 204(4):951-61. [PubMed: 17420265]  [MGI Ref ID J:125743]

Qian S; Fu F; Li Y; Gao L; Lu L; Noyola H; Rao AS; Thomson AW; Fung JJ. 1995. Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization. Immunology 85(1):82-7. [PubMed: 7635525]  [MGI Ref ID J:25162]

Raffegerst SH; Hoelzlwimmer G; Kunder S; Mysliwietz J; Quintanilla-Martinez L; Schendel DJ. 2009. Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice. PLoS One 4(12):e8539. [PubMed: 20046882]  [MGI Ref ID J:155936]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Ruby CE; Redmond WL; Haley D; Weinberg AD. 2007. Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses. Eur J Immunol 37(1):157-66. [PubMed: 17183611]  [MGI Ref ID J:117051]

Ruggiero L; Connor MP; Chen J; Langen R; Finnemann SC. 2012. Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Proc Natl Acad Sci U S A 109(21):8145-8. [PubMed: 22566632]  [MGI Ref ID J:184772]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Sacks JA; Bevan MJ. 2008. TRAIL Deficiency Does Not Rescue Impaired CD8+ T Cell Memory Generated in the Absence of CD4+ T Cell Help. J Immunol 180(7):4570-6. [PubMed: 18354179]  [MGI Ref ID J:132990]

Sakaguchi S; Hombauer M; Bilic I; Naoe Y; Schebesta A; Taniuchi I; Ellmeier W. 2010. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol 11(5):442-8. [PubMed: 20383150]  [MGI Ref ID J:158947]

Sakoda Y; Hashimoto D; Asakura S; Takeuchi K; Harada M; Tanimoto M; Teshima T. 2007. Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood 109(4):1756-64. [PubMed: 17032915]  [MGI Ref ID J:144463]

Sato T; Ohno S; Hayashi T; Sato C; Kohu K; Satake M; Habu S. 2005. Dual functions of runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity 22(3):317-28. [PubMed: 15780989]  [MGI Ref ID J:97028]

Savage AK; Constantinides MG; Bendelac A. 2011. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol 186(10):5801-6. [PubMed: 21478405]  [MGI Ref ID J:173090]

Schmidt D; Verdaguer J; Averill N; Santamaria P. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186(7):1059-75. [PubMed: 9314555]  [MGI Ref ID J:108768]

Serwold T; Hochedlinger K; Swindle J; Hedgpeth J; Jaenisch R; Weissman IL. 2010. T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci U S A 107(44):18939-43. [PubMed: 20956329]  [MGI Ref ID J:166157]

Setoguchi R; Tachibana M; Naoe Y; Muroi S; Akiyama K; Tezuka C; Okuda T; Taniuchi I. 2008. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319(5864):822-5. [PubMed: 18258917]  [MGI Ref ID J:131081]

Shedlock DJ; Whitmire JK; Tan J; MacDonald AS; Ahmed R; Shen H. 2003. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol 170(4):2053-63. [PubMed: 12574376]  [MGI Ref ID J:126911]

Shin JS; Ebersold M; Pypaert M; Delamarre L; Hartley A; Mellman I. 2006. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature 444(7115):115-8. [PubMed: 17051151]  [MGI Ref ID J:115629]

Simmons KB; Wubeshet M; Ames KT; McMahan CJ; Hale JS; Fink PJ. 2012. Modulation of TCRbeta surface expression during TCR revision. Cell Immunol 272(2):124-9. [PubMed: 22138498]  [MGI Ref ID J:181373]

Sofi MH; Liu Z; Zhu L; Yu Q; Kaplan MH; Chang CH. 2010. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol 47(6):1262-8. [PubMed: 20080304]  [MGI Ref ID J:158374]

Sofi MH; Qiao Y; Ansel KM; Kubo M; Chang CH. 2011. Induction and Maintenance of IL-4 Expression Are Regulated Differently by the 3' Enhancer in CD4 T Cells. J Immunol 186(5):2792-9. [PubMed: 21282512]  [MGI Ref ID J:169377]

Sohn SJ; Forbush KA; Pan XC; Perlmutter RM. 2001. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes. J Immunol 166(4):2209-17. [PubMed: 11160274]  [MGI Ref ID J:126139]

Srinivasan A; Salazar-Gonzalez RM; Jarcho M; Sandau MM; Lefrancois L; McSorley SJ. 2007. Innate immune activation of CD4 T cells in salmonella-infected mice is dependent on IL-18. J Immunol 178(10):6342-9. [PubMed: 17475863]  [MGI Ref ID J:146116]

Stephen TL; Tikhonova A; Riberdy JM; Laufer TM. 2009. The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol 183(9):5554-62. [PubMed: 19843939]  [MGI Ref ID J:156798]

Stephen TL; Wilson BS; Laufer TM. 2012. Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. Proc Natl Acad Sci U S A 109(19):7415-20. [PubMed: 22529380]  [MGI Ref ID J:184812]

Stephens GL; Andersson J; Shevach EM. 2007. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol 178(11):6901-11. [PubMed: 17513739]  [MGI Ref ID J:147842]

Stevenson PG; Belz GT; Altman JD; Doherty PC. 1998. Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice. Proc Natl Acad Sci U S A 95(26):15565-70. [PubMed: 9861009]  [MGI Ref ID J:120034]

Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. [PubMed: 12625509]  [MGI Ref ID J:82325]

Stojakovic M; Salazar-Fontana LI; Tatari-Calderone Z; Badovinac VP; Santori FR; Kovalovsky D; Sant'Angelo D; Harty JT; Vukmanovic S. 2008. Adaptable TCR avidity thresholds for negative selection. J Immunol 181(10):6770-8. [PubMed: 18981094]  [MGI Ref ID J:140950]

Strutt TM; McKinstry KK; Dibble JP; Winchell C; Kuang Y; Curtis JD; Huston G; Dutton RW; Swain SL. 2010. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16(5):558-64, 1p following 564. [PubMed: 20436484]  [MGI Ref ID J:160609]

Su HC; Cousens LP; Fast LD; Slifka MK; Bungiro RD; Ahmed R; Biron CA. 1998. CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J Immunol 160(10):5007-17. [PubMed: 9590250]  [MGI Ref ID J:111005]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sun J; Dodd H; Moser EK; Sharma R; Braciale TJ. 2011. CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34. [PubMed: 21297642]  [MGI Ref ID J:170347]

Sun JC; Bevan MJ. 2004. Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J Immunol 172(6):3385-9. [PubMed: 15004136]  [MGI Ref ID J:88609]

Sun JC; Williams MA; Bevan MJ. 2004. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 5(9):927-33. [PubMed: 15300249]  [MGI Ref ID J:92169]

Suzuki H; Punt JA; Granger LG; Singer A. 1995. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2(4):413-25. [PubMed: 7719943]  [MGI Ref ID J:189417]

Swee LK; Bosco N; Malissen B; Ceredig R; Rolink A. 2009. Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 113(25):6277-87. [PubMed: 19211508]  [MGI Ref ID J:150095]

Szabo P; Zhao K; Kirman I; Le Maoult J; Dyall R; Cruikshank W; Weksler ME. 1998. Maturation of B cell precursors is impaired in thymic-deprived nude and old mice. J Immunol 161(5):2248-53. [PubMed: 9725218]  [MGI Ref ID J:118431]

Szymczak WA; Deepe GS Jr. 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection. Infect Immun 78(5):2125-37. [PubMed: 20194586]  [MGI Ref ID J:159184]

Takahama Y; Suzuki H; Katz KS; Grusby MJ; Singer A. 1994. Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC. Nature 371(6492):67-70. [PubMed: 7915400]  [MGI Ref ID J:113006]

Tan YX; Manz BN; Freedman TS; Zhang C; Shokat KM; Weiss A. 2014. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol 15(2):186-94. [PubMed: 24317039]  [MGI Ref ID J:208674]

Tanaka Y; Koido S; Xia J; Ohana M; Liu C; Cote GM; Sawyer DB; Calderwood S; Gong J. 2004. Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. J Immunol 172(12):7848-58. [PubMed: 15187169]  [MGI Ref ID J:90828]

Taylor DK; Walsh PT; LaRosa DF; Zhang J; Burchill MA; Farrar MA; Turka LA. 2006. Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol 177(4):2216-23. [PubMed: 16887981]  [MGI Ref ID J:138395]

Taylor JA; Havari E; McInerney MF; Bronson R; Wucherpfennig KW; Lipes MA. 2004. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol 172(4):2651-8. [PubMed: 14764740]  [MGI Ref ID J:88055]

Terauchi M; Li JY; Bedi B; Baek KH; Tawfeek H; Galley S; Gilbert L; Nanes MS; Zayzafoon M; Guldberg R; Lamar DL; Singer MA; Lane TF; Kronenberg HM; Weitzmann MN; Pacifici R. 2009. T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10(3):229-40. [PubMed: 19723499]  [MGI Ref ID J:152384]

Tomura M; Yu WG; Ahn HJ; Yamashita M; Yang YF; Ono S; Hamaoka T; Kawano T; Taniguchi M; Koezuka Y; Fujiwara H. 1999. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol 163(1):93-101. [PubMed: 10384104]  [MGI Ref ID J:119894]

Toubai T; Tawara I; Sun Y; Liu C; Nieves E; Evers R; Friedman T; Korngold R; Reddy P. 2012. Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells. Blood 119(16):3844-53. [PubMed: 22101894]  [MGI Ref ID J:183822]

Tremblay M; Tremblay CS; Herblot S; Aplan PD; Hebert J; Perreault C; Hoang T. 2010. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev 24(11):1093-105. [PubMed: 20516195]  [MGI Ref ID J:160814]

Tripp RA; Sarawar SR; Doherty PC. 1995. Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene. J Immunol 155(6):2955-9. [PubMed: 7673713]  [MGI Ref ID J:28583]

Trivedi S; Zang Y; Culpepper S; Rosenbaum E; Fernandez I; Martinez L; Hoffman RW; Greidinger EL. 2010. T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. Clin Immunol 137(2):281-7. [PubMed: 20797908]  [MGI Ref ID J:168439]

Tyznik AJ; Sun JC; Bevan MJ. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 199(4):559-65. [PubMed: 14769854]  [MGI Ref ID J:90469]

Vallance BA; Hewlett BR; Snider DP; Collins SM. 1998. T cell-mediated exocrine pancreatic damage in major histocompatibility complex class II-deficient mice. Gastroenterology 115(4):978-87. [PubMed: 9753501]  [MGI Ref ID J:50988]

Viret C; He X; Janeway CA Jr. 2000. On the self-referential nature of naive MHC class II-restricted T cells. J Immunol 165(11):6183-92. [PubMed: 11086052]  [MGI Ref ID J:119230]

Walseng E; Furuta K; Bosch B; Weih KA; Matsuki Y; Bakke O; Ishido S; Roche PA. 2010. Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. Proc Natl Acad Sci U S A 107(47):20465-70. [PubMed: 21059907]  [MGI Ref ID J:166595]

Wang D; Claus CL; Vaccarelli G; Braunstein M; Schmitt TM; Zuniga-Pflucker JC; Rothenberg EV; Anderson MK. 2006. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors. J Immunol 177(1):109-19. [PubMed: 16785505]  [MGI Ref ID J:134406]

Wang D; Zheng M; Lei L; Ji J; Yao Y; Qiu Y; Ma L; Lou J; Ouyang C; Zhang X; He Y; Chi J; Wang L; Kuang Y; Wang J; Cao X; Lu L. 2012. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8. [PubMed: 22561606]  [MGI Ref ID J:186446]

Wang JC; Livingstone AM. 2003. Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo. J Immunol 171(12):6339-43. [PubMed: 14662830]  [MGI Ref ID J:118459]

Watte CM; Nakamura T; Lau CH; Ortaldo JR; Stein-Streilein J. 2008. Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J Leukoc Biol 83(4):928-35. [PubMed: 18192489]  [MGI Ref ID J:134192]

Weber SE; Tian H; Pirofski LA. 2011. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol 186(1):432-42. [PubMed: 21135172]  [MGI Ref ID J:168003]

Wei DG; Curran SA; Savage PB; Teyton L; Bendelac A. 2006. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med 203(5):1197-207. [PubMed: 16651387]  [MGI Ref ID J:124137]

Wen L; Chen NY; Tang J; Sherwin R; Wong FS. 2001. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J Clin Invest 107(7):871-80. [PubMed: 11285306]  [MGI Ref ID J:68641]

Wen L; Wong FS; Tang J; Chen NY; Altieri M; David C; Flavell R; Sherwin R. 2000. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med 191(1):97-104. [PubMed: 10620608]  [MGI Ref ID J:59245]

White AJ; Withers DR; Parnell SM; Scott HS; Finke D; Lane PJ; Jenkinson EJ; Anderson G. 2008. Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol 38(4):942-7. [PubMed: 18350550]  [MGI Ref ID J:133775]

Wijayalath W; Majji S; Kleschenko Y; Pow-Sang L; Brumeanu TD; Villasante EF; Vasta GR; Fernandez-Robledo JA; Casares S. 2014. Humanized HLA-DR4 mice fed with the protozoan pathogen of oysters Perkinsus marinus (Dermo) do not develop noticeable pathology but elicit systemic immunity. PLoS One 9(1):e87435. [PubMed: 24498105]  [MGI Ref ID J:212680]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Wills-Karp M; Rani R; Dienger K; Lewkowich I; Fox JG; Perkins C; Lewis L; Finkelman FD; Smith DE; Bryce PJ; Kurt-Jones EA; Wang TC; Sivaprasad U; Hershey GK; Herbert DR. 2012. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med 209(3):607-22. [PubMed: 22329990]  [MGI Ref ID J:182513]

Xu R; Johnson AJ; Liggitt D; Bevan MJ. 2004. Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol 172(10):6265-71. [PubMed: 15128815]  [MGI Ref ID J:89851]

Yamada A; Chandraker A; Laufer TM; Gerth AJ; Sayegh MH; Auchincloss H Jr. 2001. Cutting edge: recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade. J Immunol 167(10):5522-6. [PubMed: 11698419]  [MGI Ref ID J:72677]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269]  [MGI Ref ID J:149301]

Yarovinsky F; Kanzler H; Hieny S; Coffman RL; Sher A. 2006. Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity 25(4):655-64. [PubMed: 17000122]  [MGI Ref ID J:114880]

Yasutomo K; Lucas B; Germain RN. 2000. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. J Immunol 165(6):3015-22. [PubMed: 10975810]  [MGI Ref ID J:120154]

Yee CS; Yao Y; Li P; Klemsz MJ; Blum JS; Chang CH. 2004. Cathepsin E: a novel target for regulation by class II transactivator. J Immunol 172(9):5528-34. [PubMed: 15100295]  [MGI Ref ID J:89650]

Yee CS; Yao Y; Xu Q; McCarthy B; Sun-Lin D; Tone M; Waldmann H; Chang CH. 2005. Enhanced production of IL-10 by dendritic cells deficient in CIITA. J Immunol 174(3):1222-9. [PubMed: 15661876]  [MGI Ref ID J:96421]

Yin X; Ladi E; Chan SW; Li O; Killeen N; Kappes DJ; Robey EA. 2007. CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. J Immunol 179(11):7358-64. [PubMed: 18025179]  [MGI Ref ID J:154818]

Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. [PubMed: 15494484]  [MGI Ref ID J:132809]

Zhang X; Munegowda MA; Yuan J; Wei Y; Xiang J. 2010. Optimal TLR9 signal converts tolerogenic CD4-8- DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses. J Leukoc Biol 88(2):393-403. [PubMed: 20466823]  [MGI Ref ID J:163943]

Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR. 2001. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet 29(3):332-6. [PubMed: 11687799]  [MGI Ref ID J:130559]

van Meerwijk JP; O'Connell EM; Germain RN. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J Immunol 154(12):6314-23. [PubMed: 7759870]  [MGI Ref ID J:110813]

van Niel G; Wubbolts R; Ten Broeke T; Buschow SI; Ossendorp FA; Melief CJ; Raposo G; van Balkom BW; Stoorvogel W. 2006. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity 25(6):885-94. [PubMed: 17174123]  [MGI Ref ID J:116754]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

van Weel V; Toes RE; Seghers L; Deckers MM; de Vries MR; Eilers PH; Sipkens J; Schepers A; Eefting D; van Hinsbergh VW; van Bockel JH; Quax PH. 2007. Natural killer cells and CD4+ T-cells modulate collateral artery development. Arterioscler Thromb Vasc Biol 27(11):2310-8. [PubMed: 17717295]  [MGI Ref ID J:134875]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThe strain is homozygous for the class II H2-Ab1tm1Gru targeted mutation and hemizygous for the beta chain transgenic (AbT1). Breeder pairs are supplied as a wildtype for the transgene x hemizgyous male or female.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3435.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4465.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

   Wild-type from the colony
   000664 C57BL/6J (approximate)
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.