Strain Name:

C57BL/6-Itgb7tm1Cgn/J

Stock Number:

002965

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Availability:

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Use Restrictions Apply, see Terms of Use
Mice homozygous for Itgb7tm1Cgn show impaired formation of gut-associated lymphoid tissue (GALT). These mice may be useful for studies lymphocyte migration and homing in inflammatory and colitis related pathology.

Description

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+F3136 (27-DEC-13)
Generation Definitions
 
Donating Investigator Klaus Rajewsky,   Max-Delbruck-Ctr. for Molecular Medicine

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Itgb7tm1Cgn targeted mutation have a marked hypoplasia of the gut-associated lymphoid tissue (GALT). This deficit is apparently due to the failure of Itgb7-deficient lymphocytes to arrest and adhere in the GALT. Beta7 integrin deficient mice also fail to mount a normal intestinal IgA response to ovalbumin and cholera toxin, and they show less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine.

Development
The Itgb7tm1Cgn targted mutation was made by Norbert Wagner in the laboratory of Dr. Klaus Rajewsky at the University of Cologne. The targeting construct was designed to replace part of exon 12 as well as exons 13 and 14 of the Itgb7 gene with a vector containing the neo resistance gene. The C57BL/6-derived B6III ES cell line was used.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Itgb7tm1Cgn allele
004944   NOD.B6-Itgb7tm1Cgn/2LtJ
004943   NOD.Cg-Selltm1Tft Itgb7tm1Cgn/LtJ
View Strains carrying   Itgb7tm1Cgn     (2 strains)

Strains carrying other alleles of Itgb7
007707   C57BL/6-Itgb7tm1Mshi/J
View Strains carrying other alleles of Itgb7     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Itgb7tm1Cgn/Itgb7tm1Cgn

        involves: C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • eosinophilic response to DSS treatment is normal   (MGI Ref ID J:111227)
    • abnormal immune system morphology   (MGI Ref ID J:34306)
      • abnormal gut-associated lymphoid tissue morphology
        • mice exhibit hypoplasia of gut-associated lymphoid tissue   (MGI Ref ID J:34306)
        • abnormal Peyer's patch follicle morphology
          • rudimentary follicles do not disrupt the contour of the intestinal wall   (MGI Ref ID J:34306)
        • small Peyer's patches
          • microscopically, Peyer's patches are reduced to 10 to 20% of wild-type despite having an increased bacterial load compared to wild-type mice   (MGI Ref ID J:34306)
          • the cellularity of Peyer's patches is reduced   (MGI Ref ID J:34306)
          • however, the number of Peyer's patches is normal   (MGI Ref ID J:34306)
      • abnormal uterine NK cell morphology
        • uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)   (MGI Ref ID J:44813)
        • increased uterine NK cell number
          • a slight increase in uterine NK cells of 144% is present in the decidua basalis   (MGI Ref ID J:44813)
      • decreased B cell number
        • the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold   (MGI Ref ID J:34306)
        • number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice   (MGI Ref ID J:34306)
      • decreased CD4-positive, alpha beta T cell number
        • the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice   (MGI Ref ID J:34306)
      • decreased eosinophil cell number
        • 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice   (MGI Ref ID J:62733)
      • decreased mast cell number
        • mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice   (MGI Ref ID J:62733)
    • abnormal immune system physiology   (MGI Ref ID J:34306)
      • abnormal leukocyte tethering or rolling
        • leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice   (MGI Ref ID J:34306)
        • leukocyte rolling and adhesion are defective   (MGI Ref ID J:34306)
      • abnormal lymphocyte physiology
        • lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice   (MGI Ref ID J:34306)
      • abnormal response to infection
        • worm expulsion is impaired (delayed) in null mice   (MGI Ref ID J:62733)
        • when primed mesenteric lymph node cells are transferred into infected wild-type mice, recipients receiving wild-type cells show significantly enhanced worm expulsion compared to those receiving Itgb7-deficient MLN cells   (MGI Ref ID J:62733)
        • when wild-type or null primed mesenteric lymph node cells are transferred into knockout recipients which are infected 1 day later, there is no protective effect conferred by wild-type cells compared to Itgb7-deficient cells   (MGI Ref ID J:62733)
        • increased susceptibility to parasitic infection   (MGI Ref ID J:90262)
  • reproductive system phenotype
  • abnormal myometrium morphology
    • while a typical metrial gland is not observed at E10, mice possess thickened myometrium with some PAS-reactive uterine NK cells   (MGI Ref ID J:44813)
    • at E14 implantation sites are poorly organized, a metrial gland develops but contains more smooth muscle fibers and fewer uterine NK cells than in wild-type mice   (MGI Ref ID J:44813)
  • abnormal uterine NK cell morphology
    • uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)   (MGI Ref ID J:44813)
    • increased uterine NK cell number
      • a slight increase in uterine NK cells of 144% is present in the decidua basalis   (MGI Ref ID J:44813)
  • embryogenesis phenotype
  • abnormal uterine NK cell morphology
    • uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)   (MGI Ref ID J:44813)
    • increased uterine NK cell number
      • a slight increase in uterine NK cells of 144% is present in the decidua basalis   (MGI Ref ID J:44813)
  • increased trophoblast giant cell number
    • trophoblast giant cells are increased in number compared to in wild-type mice   (MGI Ref ID J:44813)
  • hematopoietic system phenotype
  • abnormal leukocyte tethering or rolling
    • leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice   (MGI Ref ID J:34306)
    • leukocyte rolling and adhesion are defective   (MGI Ref ID J:34306)
  • abnormal lymphocyte physiology
    • lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice   (MGI Ref ID J:34306)
  • abnormal uterine NK cell morphology
    • uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)   (MGI Ref ID J:44813)
    • increased uterine NK cell number
      • a slight increase in uterine NK cells of 144% is present in the decidua basalis   (MGI Ref ID J:44813)
  • decreased B cell number
    • the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold   (MGI Ref ID J:34306)
    • number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice   (MGI Ref ID J:34306)
  • decreased CD4-positive, alpha beta T cell number
    • the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice   (MGI Ref ID J:34306)
  • decreased eosinophil cell number
    • 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice   (MGI Ref ID J:62733)
  • decreased mast cell number
    • mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice   (MGI Ref ID J:62733)
  • cellular phenotype
  • abnormal leukocyte tethering or rolling
    • leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice   (MGI Ref ID J:34306)
    • leukocyte rolling and adhesion are defective   (MGI Ref ID J:34306)

Itgb7tm1Cgn/Itgb7tm1Cgn

        C57BL/6-Itgb7tm1Cgn/J
  • immune system phenotype
  • abnormal leukocyte migration
    • labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts   (MGI Ref ID J:127413)
  • colitis
    • only a mild form of colitis develops when nażve CD4 T cells from these mice are transferred to immunocompromised mice as opposed to the robust colitis that occurs when the T cells come from wild-type mice   (MGI Ref ID J:127413)
    • the number of transferred T cells found in the large intestine is reduced by two-thirds   (MGI Ref ID J:127413)
  • digestive/alimentary phenotype
  • colitis
    • only a mild form of colitis develops when nażve CD4 T cells from these mice are transferred to immunocompromised mice as opposed to the robust colitis that occurs when the T cells come from wild-type mice   (MGI Ref ID J:127413)
    • the number of transferred T cells found in the large intestine is reduced by two-thirds   (MGI Ref ID J:127413)
  • cellular phenotype
  • abnormal leukocyte migration
    • labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts   (MGI Ref ID J:127413)
  • hematopoietic system phenotype
  • abnormal leukocyte migration
    • labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts   (MGI Ref ID J:127413)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Itgb7tm1Cgn related

Cell Biology Research
Defects in Cell Adhesion Molecules

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Lymphoid Tissue Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Itgb7tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) Itgbtm1Ctg; beta7-;
Mutation Made By Norbert Wagner,   University of Cologne
Strain of OriginC57BL/6J
ES Cell Line NameBL/6-III
ES Cell Line StrainC57BL/6J
Gene Symbol and Name Itgb7, integrin beta 7
Chromosome 15
Molecular Note A neomycin resistance cassette replaced part of exon 12 and all of exons 13 and 14, which encode the transmembrane and part of the extracellular domains. [MGI Ref ID J:34306]

Genotyping

Genotyping Information

Genotyping Protocols

Itgb7tm1Cgn, High Resolution Melting
Itgb7tm1Cgn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wagner N; Lohler J; Kunkel EJ; Ley K; Leung E; Krissansen G; Rajewsky K; Muller W. 1996. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature 382(6589):366-70. [PubMed: 8684468]  [MGI Ref ID J:34306]

Additional References

Itgb7tm1Cgn related

Abonia JP; Hallgren J; Jones T; Shi T; Xu Y; Koni P; Flavell RA; Boyce JA; Austen KF; Gurish MF. 2006. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 108(5):1588-94. [PubMed: 16670268]  [MGI Ref ID J:138072]

Agnello D; Denimal D; Lavaux A; Blondeau-Germe L; Lu B; Gerard NP; Gerard C; Pothier P. 2013. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol 190(9):4836-47. [PubMed: 23547118]  [MGI Ref ID J:195497]

Apostolaki M; Manoloukos M; Roulis M; Wurbel MA; Muller W; Papadakis KA; Kontoyiannis DL; Malissen B; Kollias G. 2008. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology 134(7):2025-35. [PubMed: 18439426]  [MGI Ref ID J:136667]

Artis D; Humphreys NE; Potten CS; Wagner N; Muller W; McDermott JR; Grencis RK; Else KJ. 2000. Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection Eur J Immunol 30(6):1656-64. [PubMed: 10898502]  [MGI Ref ID J:62733]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Collins CB; Ho J; Wilson TE; Wermers JD; Tlaxca JL; Lawrence MB; Solga M; Lannigan J; Rivera-Nieves J. 2008. CD44 deficiency attenuates chronic murine ileitis. Gastroenterology 135(6):1993-2002. [PubMed: 18854186]  [MGI Ref ID J:145626]

Croy BA; Ashkar AA; Foster RA; DiSanto JP; Magram J; Carson D; Gendler SJ; Grusby MJ; Wagner N; Muller W; Guimond MJ. 1997. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy J Reprod Immunol 35(2):111-33. [PubMed: 9421796]  [MGI Ref ID J:44813]

Czarneski J; Berguer P; Bekinschtein P; Kim DC; Hakimpour P; Wagner N; Nepomnaschy I; Piazzon I; Ross SR. 2002. Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes. Eur J Immunol 32(4):945-56. [PubMed: 11920560]  [MGI Ref ID J:76001]

DeNucci CC; Pagan AJ; Mitchell JS; Shimizu Y. 2010. Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit. J Immunol 184(5):2458-67. [PubMed: 20118278]  [MGI Ref ID J:159655]

Denucci CC; Shimizu Y. 2011. {beta}1 Integrin Is Critical for the Maintenance of Antigen-Specific CD4 T Cells in the Bone Marrow but Not Long-Term Immunological Memory. J Immunol 186(7):4019-26. [PubMed: 21357540]  [MGI Ref ID J:170691]

Dutt S; Ermann J; Tseng D; Liu YP; George TI; Fathman CG; Strober S. 2005. L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood 106(12):4009-15. [PubMed: 16105972]  [MGI Ref ID J:124067]

Fernekorn U; Butcher EC; Behrends J; Hartz S; Kruse A. 2004. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol 34(12):3423-33. [PubMed: 15484189]  [MGI Ref ID J:94597]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Ghosh S; Chackerian AA; Parker CM; Ballantyne CM; Behar SM. 2006. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol 176(8):4914-22. [PubMed: 16585587]  [MGI Ref ID J:131154]

Gorfu G; Rivera-Nieves J; Hoang S; Abbott DW; Arbenz-Smith K; Azar DW; Pizarro TT; Cominelli F; McDuffie M; Ley K. 2010. Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. J Immunol 185(9):5561-8. [PubMed: 20926792]  [MGI Ref ID J:165177]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hadis U; Wahl B; Schulz O; Hardtke-Wolenski M; Schippers A; Wagner N; Muller W; Sparwasser T; Forster R; Pabst O. 2011. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity 34(2):237-46. [PubMed: 21333554]  [MGI Ref ID J:168976]

Ho J; Kurtz CC; Naganuma M; Ernst PB; Cominelli F; Rivera-Nieves J. 2008. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol 180(4):2573-80. [PubMed: 18250468]  [MGI Ref ID J:131978]

Karsten CM; Behrends J; Wagner AK; Fuchs F; Figge J; Schmudde I; Hellberg L; Kruse A. 2009. DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells. Eur J Immunol 39(8):2203-14. [PubMed: 19593769]  [MGI Ref ID J:151694]

Kuklin NA; Rott L; Feng N; Conner ME; Wagner N; Muller W; Greenberg HB. 2001. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha(4)beta(7) integrin expression but does not require IgA antibody production. J Immunol 166(3):1894-902. [PubMed: 11160237]  [MGI Ref ID J:67098]

Kunkel EJ; Ramos CL; Steeber DA; Muller W; Wagner N; Tedder TF; Ley K. 1998. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J Immunol 161(5):2449-56. [PubMed: 9725243]  [MGI Ref ID J:112049]

Lammermann T; Bader BL; Monkley SJ; Worbs T; Wedlich-Soldner R; Hirsch K; Keller M; Forster R; Critchley DR; Fassler R; Sixt M. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453(7191):51-5. [PubMed: 18451854]  [MGI Ref ID J:134784]

Mancassola R; Lacroix-Lamande S; Barrier M; Naciri M; Salmon H; Laurent F. 2004. Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection. Infect Immun 72(6):3634-7. [PubMed: 15155674]  [MGI Ref ID J:90262]

Park EJ; Mora JR; Carman CV; Chen J; Sasaki Y; Cheng G; von Andrian UH; Shimaoka M. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest 117(9):2526-38. [PubMed: 17786243]  [MGI Ref ID J:127413]

Quast T; Tappertzhofen B; Schild C; Grell J; Czeloth N; Forster R; Alon R; Fraemohs L; Dreck K; Weber C; Lammermann T; Sixt M; Kolanus W. 2009. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 113(23):5801-10. [PubMed: 19346499]  [MGI Ref ID J:149500]

Schippers A; Kochut A; Pabst O; Frischmann U; Clahsen T; Tenbrock K; Muller W; Wagner N. 2012. beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses. Clin Immunol 144(2):87-97. [PubMed: 22710445]  [MGI Ref ID J:188011]

Steeber DA; Tang ML; Zhang XQ; Muller W; Wagner N; Tedder TF. 1998. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol 161(12):6638-47. [PubMed: 9862692]  [MGI Ref ID J:112112]

Sydora BC; Wagner N; Lohler J; Yakoub G; Kronenberg M; Muller W; Aranda R. 2002. beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. Clin Exp Immunol 129(1):35-42. [PubMed: 12100020]  [MGI Ref ID J:115570]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Wagner N; Lohler J; Tedder TF; Rajewsky K; Muller W; Steeber DA. 1998. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol 28(11):3832-9. [PubMed: 9842926]  [MGI Ref ID J:114211]

Waldman E; Lu SX; Hubbard VM; Kochman AA; Eng JM; Terwey TH; Muriglan SJ; Kim TD; Heller G; Murphy GF; Liu C; Alpdogan O; van den Brink MR. 2006. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood 107(4):1703-11. [PubMed: 16291587]  [MGI Ref ID J:129395]

Wang C; Kang SG; HogenEsch H; Love PE; Kim CH. 2010. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol 184(10):5519-26. [PubMed: 20400707]  [MGI Ref ID J:160990]

Wang C; McDonough JS; McDonald KG; Huang C; Newberry RD. 2008. Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation. J Immunol 181(6):4052-61. [PubMed: 18768861]  [MGI Ref ID J:139096]

Yamada D; Kadono T; Masui Y; Yanaba K; Sato S. 2014. beta7 Integrin controls mast cell recruitment, whereas alphaE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. J Immunol 192(9):4112-21. [PubMed: 24670804]  [MGI Ref ID J:209980]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Itgb7tm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Itgb7tm1Cgn x Homozygous for Itgb7tm1Cgn  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Itgb7tm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Itgb7tm1Cgn x Homozygous for Itgb7tm1Cgn  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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