Description

Strain Information

Former Names BPL/1@J    (Changed: 15-DEC-04 ) Blood Pressure Low    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype b Generation F65+35 (01-MAR-13) Generation Definitions

Appearance
misty toned gray
Related Genotype: unknown

Description
The hypertensive BPH/2 mice (Stock No. 003005) have elevated systolic blood pressures at five weeks and by 150 days differ from the BPL/1 by 60 mmHg. The BPH/2 strain has a higher heart rate, larger hearts and kidneys, and higher hematocrits than the BPL/1. It also has lower renin, aldosterone and angiotensin I levels compared to the BPL/1 and BPN/3 (Stock No. 003004). The original HBP (high blood pressures) and LBP (low blood pressure) selected lines showed a number of biochemical and physiological differences which have not been reexamined in the inbred strains. These include differences in brain catecholamines, calmodulin concentrations, heat sensitivity, alcohol preference, and longevity. The differences in longevity were striking. The hypotensive selected lines lived two to three hundred days longer, on average, than the hypertensive selected line. Biometrical genetic analysis suggested that three to five genes are responsible for the difference in blood pressure between the BPH/2 and BPL/1. A recent genome scan of an F2 from a BPH/2 x BPL/1 cross found three chromosome locations that cosegregated with blood pressure. Two of these sites were verified by candidate gene cosegregation: angiotensinogen on chromosome 8 and mouse kallikrein binding protein on chromosome 12.

Development
In 1964, a two-way selection program was initiated at the Jackson Laboratory to produce hypertensive and hypotensive mice. These colonies were moved to the University of Kansas in 1970, where the selection program continued for a total of 30 generations. The maximum divergence between the two selection lines, HBP and LBP, was 60 mmHg. Brother-sister matings followed the selection program to produce the inbred hypertensive BPH/2 and hypotensive BPL/1 strains. A non-selected control was maintained throughout the selection program; brother-sister matings from this line produced the BPN/3 normotensive strain. These three strains were returned to The Jackson Laboratory in 1997.

Control Information

	Control
	003004 BPN/3J
Considerations for Choosing Controls

Related Strains

Blood Pressure High, Low and Normal Strains

003005	BPH/2J
003004	BPN/3J

View Blood Pressure High, Low and Normal Strains     (2 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: BPL/1

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

       

• cardiovascular system phenotype
• decreased heart rate
  • BHP/2J mice have a heart rate more than 100 beats per minute faster than BPL/1J and the heart rate of BPN/3J is intermediate compared with these two related strains   (MGI Ref ID J:41893)
• decreased heart weight
  • BPL/1J mice have a decreased heart weight relative to BPH/2J and BPN/3J   (MGI Ref ID J:41893)
• decreased systemic arterial systolic blood pressure
  • systolic blood pressure of 69 +/- 1.7 mm HG at 4 to 15 weeks of age is much lower than that of normotensive BPN/3J or hypertensive BPH/2J   (MGI Ref ID J:41893)
• hematopoietic system phenotype
• decreased hematocrit
  • BPN/3J and BPL/1J mice have a lower hematocrit than BPH/2J mice   (MGI Ref ID J:41893)
• renal/urinary system phenotype
• decreased kidney weight
  • BPL/1J have lower kidney weights than BPH/2J or BPN/3J   (MGI Ref ID J:41893)
• behavior/neurological phenotype
• abnormal behavior
  • strain specific variations in intake of NaCl, KCl, CaCl2, and plain water are found between females of BPL/1J, BPH/2J, and BPN/3J inbred strains, but these differences fail to draw a correlation between hypertension and fluid or salt consumption   (MGI Ref ID J:49976)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cardiovascular Research
Hypotension

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bachmanov AA; Schlager G; Tordoff MG; Beauchamp GK. 1998. Consumption of electrolytes and quinine by mouse strains with different blood pressures. Physiol Behav 64(3):323-30. [PubMed: 9748100]  [MGI Ref ID J:49976]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Schlager G; Sides J. 1997. Characterization of hypertensive and hypotensive inbred strains of mice. Lab Anim Sci 47(3):288-92. [PubMed: 9241632]  [MGI Ref ID J:41893]

Wong C; Mahapatra NR; Chitbangonsyn S; Mahboubi P; Mahata M; Mahata SK; O'Connor DT. 2003. The angiotensin II receptor (Agtr1a): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse. Physiol Genomics 14(1):83-93. [PubMed: 12697907]  [MGI Ref ID J:86190]

Additional References

Schlager G. 1994. Biometrical genetic analysis of blood pressure level in the genetically hypertensive mouse. Clin Exp Hypertens 16(6):809-24. [PubMed: 7858561]  [MGI Ref ID J:21671]

Schlager G. 1974. Selection for blood pressure levels in mice. Genetics 76(3):537-49. [PubMed: 4833575]  [MGI Ref ID J:24609]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Special Mutant Stock Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	003004 BPN/3J
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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