Strain Name:

B6;129S1-Il1r1tm1Roml/J

Stock Number:

003018

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Mice homozygous for Il1r1tm1Roml exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta. IL1 receptor type I deficient mice have a reduced delayed type hypersensitivity response and are highly susceptible to infection by Listeria monocytogenes.

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+F29 (19-MAY-11)
Generation Definitions
 
Donating InvestigatorDr. Mark A. Labow,   Novartis Corporation

Appearance
white-bellied agouti
Related Genotype: Aw/?

black
Related Genotype: a/a

Description
Mice homozygous for the Il1r1tm1Roml targeted mutation exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta. IL1 receptor type I deficient mice have a reduced delayed type hypersensitivity response and are highly susceptible to infection by Listeria monocytogenes.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il1r1tm1Roml allele
005078   NOD.Cg-Il1r1tm1Roml/HetJ
View Strains carrying   Il1r1tm1Roml     (1 strain)

Strains carrying other alleles of Il1r1
003245   B6.129S7-Il1r1tm1Imx/J
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
View Strains carrying other alleles of Il1r1     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il1r1tm1Roml/Il1r1tm1Roml

        involves: 129S1/Sv * C57BL/6
  • immune system phenotype
  • abnormal circulating serum amyloid protein level
    • reduced levels of serum amyloid protein and serum amyloid A after turpentine injection   (MGI Ref ID J:42373)
  • decreased circulating interleukin-6 level
    • mice have reduced circulating levels of IL-6 after turpentine injection   (MGI Ref ID J:42373)
  • decreased interleukin-6 secretion
    • fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta   (MGI Ref ID J:42373)
  • decreased susceptibility to type IV hypersensitivity reaction
    • 50% reduction in paw swelling one day after injection in paw with methylated BSA   (MGI Ref ID J:42373)
  • increased susceptibility to bacterial infection
    • 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates   (MGI Ref ID J:42373)
  • homeostasis/metabolism phenotype
  • abnormal circulating serum amyloid protein level
    • reduced levels of serum amyloid protein and serum amyloid A after turpentine injection   (MGI Ref ID J:42373)
  • decreased circulating interleukin-6 level
    • mice have reduced circulating levels of IL-6 after turpentine injection   (MGI Ref ID J:42373)
  • impaired febrile response
    • IL-1beta injection fails to increase body temperature   (MGI Ref ID J:42373)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Il1r1tm1Roml/Il1r1tm1Roml

        C.Cg-Il1r1tm1Roml
  • immune system phenotype
  • decreased T cell number
    • in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented   (MGI Ref ID J:82863)
  • decreased T cell proliferation
    • proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures   (MGI Ref ID J:82863)
  • decreased eosinophil cell number
    • cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals   (MGI Ref ID J:82863)
  • decreased immunoglobulin level
    • after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum   (MGI Ref ID J:82863)
  • hematopoietic system phenotype
  • decreased T cell number
    • in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented   (MGI Ref ID J:82863)
  • decreased T cell proliferation
    • proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures   (MGI Ref ID J:82863)
  • decreased eosinophil cell number
    • cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals   (MGI Ref ID J:82863)
  • decreased immunoglobulin level
    • after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum   (MGI Ref ID J:82863)

Il1r1tm1Roml/Il1r1tm1Roml

        involves: 129S1/Sv * BALB/c
  • immune system phenotype
  • impaired neutrophil chemotaxis
    • following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired   (MGI Ref ID J:124226)
  • cellular phenotype
  • impaired neutrophil chemotaxis
    • following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired   (MGI Ref ID J:124226)
  • homeostasis/metabolism phenotype
  • decreased incidence of tumors by chemical induction
    • mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice   (MGI Ref ID J:191239)
  • tumorigenesis
  • decreased incidence of tumors by chemical induction
    • mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice   (MGI Ref ID J:191239)
  • hematopoietic system phenotype
  • impaired neutrophil chemotaxis
    • following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired   (MGI Ref ID J:124226)

Il1r1tm1Roml/Il1r1tm1Roml

        involves: 129S1/Sv
  • immune system phenotype
  • decreased neutrophil cell number
    • in the skin of IMQ-treated mice   (MGI Ref ID J:193548)
  • decreased susceptibility to induced arthritis
    • do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days   (MGI Ref ID J:120707)
  • skeleton phenotype
  • decreased susceptibility to induced arthritis
    • do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days   (MGI Ref ID J:120707)
  • integument phenotype
  • *normal* integument phenotype
    • mice have normal skin   (MGI Ref ID J:126327)
  • hematopoietic system phenotype
  • decreased neutrophil cell number
    • in the skin of IMQ-treated mice   (MGI Ref ID J:193548)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • IMQ-treated mice develop psoriasis as in wild-type mice   (MGI Ref ID J:193548)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il1r1tm1Roml related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il1r1tm1Roml
Allele Name targeted mutation 1, Mark A Labow
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-1RI-deficient; IL-1RI-; IL-1rKO;
Mutation Made ByDr. Mark Labow,   Novartis Corporation
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Il1r1, interleukin 1 receptor, type I
Chromosome 1
Gene Common Name(s) CD121A; D2S1473; IL-1 receptor alpha chain; IL-1R-alpha; IL-iR; IL1R; IL1RA; Il1r-1; P80;
Molecular Note A neomycin resistance cassette replaced an ~ 1 kb region of the DNA and included one exon of the gene, which encodes the signal peptide and contains a possible ATG initiation codon. [MGI Ref ID J:42373]

Genotyping

Genotyping Information

Genotyping Protocols

Il1r1tm1Roml,

Separated MCA


Il1r1tm1Roml, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Labow M; Shuster D; Zetterstrom M; Nunes P; Terry R; Cullinan EB ; Bartfai T ; Solorzano C ; Moldawer LL ; Chizzonite R ; McIntyre KW. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol 159(5):2452-61. [PubMed: 9278338]  [MGI Ref ID J:42373]

Additional References

Goshen I; Yirmiya R; Iverfeldt K; Weidenfeld J. 2003. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion. Endocrinology 144(10):4453-8. [PubMed: 12960098]  [MGI Ref ID J:85770]

Graves DT; Nooh N; Gillen T; Davey M; Patel S; Cottrell D; Amar S. 2001. Il-1 plays a critical role in oral, but not dermal, wound healing. J Immunol 167(9):5316-20. [PubMed: 11673547]  [MGI Ref ID J:72674]

Il1r1tm1Roml related

Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. [PubMed: 17339472]  [MGI Ref ID J:144277]

Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 185(3):1794-803. [PubMed: 20585036]  [MGI Ref ID J:162467]

Avital A; Goshen I; Kamsler A; Segal M; Iverfeldt K; Richter-Levin G; Yirmiya R. 2003. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13(7):826-34. [PubMed: 14620878]  [MGI Ref ID J:180427]

Bajayo A; Bar A; Denes A; Bachar M; Kram V; Attar-Namdar M; Zallone A; Kovacs KJ; Yirmiya R; Bab I. 2012. Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A 109(38):15455-60. [PubMed: 22949675]  [MGI Ref ID J:190149]

Bajayo A; Goshen I; Feldman S; Csernus V; Iverfeldt K; Shohami E; Yirmiya R; Bab I. 2005. Central IL-1 receptor signaling regulates bone growth and mass. Proc Natl Acad Sci U S A 102(36):12956-61. [PubMed: 16126903]  [MGI Ref ID J:101424]

Barbosa FL; Lin M; Santhiago MR; Singh V; Agrawal V; Wilson SE. 2012. Interleukin-1 receptor role in the viability of corneal myofibroblasts. Exp Eye Res 96(1):65-9. [PubMed: 22251454]  [MGI Ref ID J:196771]

Belisle SE; Tisoncik JR; Korth MJ; Carter VS; Proll SC; Swayne DE; Pantin-Jackwood M; Tumpey TM; Katze MG. 2010. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 84(24):12576-88. [PubMed: 20926563]  [MGI Ref ID J:166538]

Bellocchio S; Montagnoli C; Bozza S; Gaziano R; Rossi G; Mambula SS; Vecchi A; Mantovani A; Levitz SM; Romani L. 2004. The contribution of the toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172(5):3059-69. [PubMed: 14978111]  [MGI Ref ID J:88227]

Bertin-Maghit S; Pang D; O'Sullivan B; Best S; Duggan E; Paul S; Thomas H; Kay TW; Harrison LC; Steptoe R; Thomas R. 2011. Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes 60(1):248-57. [PubMed: 20980463]  [MGI Ref ID J:170298]

Blumberg H; Dinh H; Trueblood ES; Pretorius J; Kugler D; Weng N; Kanaly ST; Towne JE; Willis CR; Kuechle MK; Sims JE; Peschon JJ. 2007. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med 204(11):2603-14. [PubMed: 17908936]  [MGI Ref ID J:126327]

Blyszczuk P; Kania G; Dieterle T; Marty RR; Valaperti A; Berthonneche C; Pedrazzini T; Berger CT; Dirnhofer S; Matter CM; Penninger JM; Luscher TF; Eriksson U. 2009. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res 105(9):912-20. [PubMed: 19762681]  [MGI Ref ID J:169954]

Bozza S; Zelante T; Moretti S; Bonifazi P; Deluca A; D'Angelo C; Giovannini G; Garlanda C; Boon L; Bistoni F; Puccetti P; Mantovani A; Romani L. 2008. Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection. J Immunol 180(6):4022-31. [PubMed: 18322211]  [MGI Ref ID J:132934]

Brydges SD; Broderick L; McGeough MD; Pena CA; Mueller JL; Hoffman HM. 2013. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest :. [PubMed: 24084736]  [MGI Ref ID J:203992]

Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000]  [MGI Ref ID J:150054]

Bujak M; Dobaczewski M; Chatila K; Mendoza LH; Li N; Reddy A; Frangogiannis NG. 2008. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 173(1):57-67. [PubMed: 18535174]  [MGI Ref ID J:137121]

Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells. J Immunol 186(9):5468-77. [PubMed: 21421852]  [MGI Ref ID J:172752]

Chae JJ; Cho YH; Lee GS; Cheng J; Liu PP; Feigenbaum L; Katz SI; Kastner DL. 2011. Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1beta Activation and Severe Autoinflammation in Mice. Immunity 34(5):755-68. [PubMed: 21600797]  [MGI Ref ID J:172117]

Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. [PubMed: 18931327]  [MGI Ref ID J:159269]

Cohen PE; Pollard JW. 1998. Normal sexual function in male mice lacking a functional type I interleukin-1 (IL-1) receptor. Endocrinology 139(2):815-8. [PubMed: 9449661]  [MGI Ref ID J:109008]

Conforti-Andreoni C; Spreafico R; Qian HL; Riteau N; Ryffel B; Ricciardi-Castagnoli P; Mortellaro A. 2011. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol 187(11):5842-50. [PubMed: 22058415]  [MGI Ref ID J:179683]

Couillin I; Vasseur V; Charron S; Gasse P; Tavernier M; Guillet J; Lagente V; Fick L; Jacobs M; Coelho FR; Moser R; Ryffel B. 2009. IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol 183(12):8195-202. [PubMed: 20007584]  [MGI Ref ID J:157458]

Court N; Vasseur V; Vacher R; Fremond C; Shebzukhov Y; Yeremeev VV; Maillet I; Nedospasov SA; Gordon S; Fallon PG; Suzuki H; Ryffel B; Quesniaux VF. 2010. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol 184(12):7057-70. [PubMed: 20488784]  [MGI Ref ID J:161134]

Deckert M; Virna S; Sakowicz-Burkiewicz M; Lutjen S; Soltek S; Bluethmann H; Schluter D. 2007. Interleukin-1 receptor type 1 is essential for control of cerebral but not systemic listeriosis. Am J Pathol 170(3):990-1002. [PubMed: 17322383]  [MGI Ref ID J:118657]

Descamps D; Le Gars M; Balloy V; Barbier D; Maschalidi S; Tohme M; Chignard M; Ramphal R; Manoury B; Sallenave JM. 2012. Toll-like receptor 5 (TLR5), IL-1beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. Proc Natl Acad Sci U S A 109(5):1619-24. [PubMed: 22307620]  [MGI Ref ID J:182039]

Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31(1):110-21. [PubMed: 19576795]  [MGI Ref ID J:151628]

Doisne JM; Soulard V; Becourt C; Amniai L; Henrot P; Havenar-Daughton C; Blanchet C; Zitvogel L; Ryffel B; Cavaillon JM; Marie JC; Couillin I; Benlagha K. 2011. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol 186(2):662-6. [PubMed: 21169541]  [MGI Ref ID J:168762]

Dostert C; Guarda G; Romero JF; Menu P; Gross O; Tardivel A; Suva ML; Stehle JC; Kopf M; Stamenkovic I; Corradin G; Tschopp J. 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 4(8):e6510. [PubMed: 19652710]  [MGI Ref ID J:152483]

Doz E; Noulin N; Boichot E; Guenon I; Fick L; Le Bert M; Lagente V; Ryffel B; Schnyder B; Quesniaux VF; Couillin I. 2008. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 180(2):1169-78. [PubMed: 18178857]  [MGI Ref ID J:130941]

Drennan MB; Stijlemans B; Van den Abbeele J; Quesniaux VJ; Barkhuizen M; Brombacher F; De Baetselier P; Ryffel B; Magez S. 2005. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol 175(4):2501-9. [PubMed: 16081822]  [MGI Ref ID J:107495]

Drexler SK; Bonsignore L; Masin M; Tardivel A; Jackstadt R; Hermeking H; Schneider P; Gross O; Tschopp J; Yazdi AS. 2012. Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A 109(45):18384-9. [PubMed: 23090995]  [MGI Ref ID J:191239]

Embry CA; Franchi L; Nunez G; Mitchell TC. 2011. Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A. Sci Signal 4(171):ra28. [PubMed: 21540455]  [MGI Ref ID J:185335]

Engler H; Bailey MT; Engler A; Stiner-Jones LM; Quan N; Sheridan JF. 2008. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology 33(1):108-17. [PubMed: 18037570]  [MGI Ref ID J:140079]

Eriksson U; Kurrer MO; Sonderegger I; Iezzi G; Tafuri A; Hunziker L; Suzuki S; Bachmaier K; Bingisser RM; Penninger JM; Kopf M. 2003. Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med 197(3):323-31. [PubMed: 12566416]  [MGI Ref ID J:124689]

Fejer G; Wegner MD; Gyory I; Cohen I; Engelhard P; Voronov E; Manke T; Ruzsics Z; Dolken L; Prazeres da Costa O; Branzk N; Huber M; Prasse A; Schneider R; Apte RN; Galanos C; Freudenberg MA. 2013. Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci U S A 110(24):E2191-8. [PubMed: 23708119]  [MGI Ref ID J:197404]

Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. [PubMed: 23995233]  [MGI Ref ID J:208219]

Fremond CM; Togbe D; Doz E; Rose S; Vasseur V; Maillet I; Jacobs M; Ryffel B; Quesniaux VF. 2007. IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 179(2):1178-89. [PubMed: 17617611]  [MGI Ref ID J:149392]

Gasse P; Mary C; Guenon I; Noulin N; Charron S; Schnyder-Candrian S; Schnyder B; Akira S; Quesniaux VF; Lagente V; Ryffel B; Couillin I. 2007. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117(12):3786-99. [PubMed: 17992263]  [MGI Ref ID J:130776]

Gasse P; Riteau N; Charron S; Girre S; Fick L; Petrilli V; Tschopp J; Lagente V; Quesniaux VF; Ryffel B; Couillin I. 2009. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 179(10):903-13. [PubMed: 19218193]  [MGI Ref ID J:164986]

Gomes MT; Campos PC; Oliveira FS; Corsetti PP; Bortoluci KR; Cunha LD; Zamboni DS; Oliveira SC. 2013. Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection. J Immunol 190(7):3629-38. [PubMed: 23460746]  [MGI Ref ID J:194921]

Goshen I; Avital A; Kreisel T; Licht T; Segal M; Yirmiya R. 2009. Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement. J Neurosci 29(11):3395-403. [PubMed: 19295146]  [MGI Ref ID J:147047]

Goshen I; Kreisel T; Ben-Menachem-Zidon O; Licht T; Weidenfeld J; Ben-Hur T; Yirmiya R. 2008. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13(7):717-28. [PubMed: 17700577]  [MGI Ref ID J:151068]

Goshen I; Kreisel T; Ounallah-Saad H; Renbaum P; Zalzstein Y; Ben-Hur T; Levy-Lahad E; Yirmiya R. 2007. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32(8-10):1106-15. [PubMed: 17976923]  [MGI Ref ID J:140080]

Goshen I; Yirmiya R; Iverfeldt K; Weidenfeld J. 2003. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion. Endocrinology 144(10):4453-8. [PubMed: 12960098]  [MGI Ref ID J:85770]

Graves DT; Nooh N; Gillen T; Davey M; Patel S; Cottrell D; Amar S. 2001. Il-1 plays a critical role in oral, but not dermal, wound healing. J Immunol 167(9):5316-20. [PubMed: 11673547]  [MGI Ref ID J:72674]

Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. [PubMed: 21349431]  [MGI Ref ID J:168972]

Harry GJ; Funk JA; Lefebvre d'Hellencourt C; McPherson CA; Aoyama M. 2008. The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. Brain Res 1194:8-20. [PubMed: 18191113]  [MGI Ref ID J:131904]

Jaillon S; Moalli F; Ragnarsdottir B; Bonavita E; Puthia M; Riva F; Barbati E; Nebuloni M; Cvetko Krajinovic L; Markotic A; Valentino S; Doni A; Tartari S; Graziani G; Montanelli A; Delneste Y; Svanborg C; Garlanda C; Mantovani A. 2014. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity 40(4):621-32. [PubMed: 24745336]  [MGI Ref ID J:209948]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Josephs MD; Solorzano CC; Taylor M; Rosenberg JJ; Topping D; Abouhamze A; Mackay SL; Hirsch E; Hirsh D; Labow M; Moldawer LL. 2000. Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra. Am J Physiol Regul Integr Comp Physiol 278(4):R824-30. [PubMed: 10749768]  [MGI Ref ID J:61600]

Jung C; Meinzer U; Montcuquet N; Thachil E; Chateau D; Thiebaut R; Roy M; Alnabhani Z; Berrebi D; Dussaillant M; Pedruzzi E; Thenet S; Cerf-Bensussan N; Hugot JP; Barreau F. 2012. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest 122(6):2239-51. [PubMed: 22565313]  [MGI Ref ID J:190499]

Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. [PubMed: 12133972]  [MGI Ref ID J:120707]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Leibundgut-Landmann S; Weidner K; Hilbi H; Oxenius A. 2011. Nonhematopoietic cells are key players in innate control of bacterial airway infection. J Immunol 186(5):3130-7. [PubMed: 21270399]  [MGI Ref ID J:169394]

Lucey EC; Keane J; Kuang PP; Snider GL; Goldstein RH. 2002. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest 82(1):79-85. [PubMed: 11796828]  [MGI Ref ID J:126680]

Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 108(16):6567-72. [PubMed: 21464320]  [MGI Ref ID J:171365]

Martinon F; Petrilli V; Mayor A; Tardivel A; Tschopp J. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440(7081):237-41. [PubMed: 16407889]  [MGI Ref ID J:124226]

Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. [PubMed: 23219391]  [MGI Ref ID J:191055]

Mayer-Barber KD; Barber DL; Shenderov K; White SD; Wilson MS; Cheever A; Kugler D; Hieny S; Caspar P; Nunez G; Schlueter D; Flavell RA; Sutterwala FS; Sher A. 2010. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 184(7):3326-30. [PubMed: 20200276]  [MGI Ref ID J:160077]

McCandless EE; Budde M; Lees JR; Dorsey D; Lyng E; Klein RS. 2009. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. J Immunol 183(1):613-20. [PubMed: 19535637]  [MGI Ref ID J:150113]

McGeough MD; Pena CA; Mueller JL; Pociask DA; Broderick L; Hoffman HM; Brydges SD. 2012. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol 189(6):2707-11. [PubMed: 22904305]  [MGI Ref ID J:189914]

McKenzie MD; Dudek NL; Mariana L; Chong MM; Trapani JA; Kay TW; Thomas HE. 2006. Perforin and Fas induced by IFN{gamma} and TNF{alpha} mediate beta cell death by OT-I CTL. Int Immunol 18(6):837-46. [PubMed: 16574667]  [MGI Ref ID J:109099]

McKenzie MD; Jamieson E; Jansen ES; Scott CL; Huang DC; Bouillet P; Allison J; Kay TW; Strasser A; Thomas HE. 2010. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59(3):644-52. [PubMed: 19959756]  [MGI Ref ID J:164154]

Mizgerd JP; Lupa MM; Hjoberg J; Vallone JC; Warren HB; Butler JP; Silverman ES. 2004. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am J Physiol Lung Cell Mol Physiol 286(6):L1302-10. [PubMed: 14966082]  [MGI Ref ID J:108146]

Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. [PubMed: 21170303]  [MGI Ref ID J:168096]

Moreland JG; Fuhrman RM; Wohlford-Lenane CL; Quinn TJ; Benda E; Pruessner JA; Schwartz DA. 2001. TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol 280(1):L173-80. [PubMed: 11133507]  [MGI Ref ID J:107839]

Noursadeghi M; Bickerstaff MC; Herbert J; Moyes D; Cohen J; Pepys MB. 2002. Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection. J Immunol 169(2):913-9. [PubMed: 12097396]  [MGI Ref ID J:123857]

Qian J; Zhu L; Li Q; Belevych N; Chen Q; Zhao F; Herness S; Quan N. 2012. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109(30):12189-94. [PubMed: 22778412]  [MGI Ref ID J:186478]

Quinton LJ; Jones MR; Robson BE; Mizgerd JP. 2009. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun 77(6):2417-26. [PubMed: 19289507]  [MGI Ref ID J:149372]

Raivich G; Liu ZQ; Kloss CU; Labow M; Bluethmann H; Bohatschek M. 2002. Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse. Exp Neurol 178(2):186-93. [PubMed: 12504878]  [MGI Ref ID J:118490]

Rectenwald JE; Moldawer LL; Huber TS; Seeger JM; Ozaki CK. 2000. Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 102(14):1697-702. [PubMed: 11015350]  [MGI Ref ID J:130541]

Reiniger N; Lee MM; Coleman FT; Ray C; Golan DE; Pier GB. 2007. Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun 75(4):1598-608. [PubMed: 17283089]  [MGI Ref ID J:119764]

Rosenzweig HL; Galster KT; Planck SR; Rosenbaum JT. 2009. NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci 50(4):1746-53. [PubMed: 19074813]  [MGI Ref ID J:146667]

Salio M; Chimenti S; De Angelis N; Molla F; Maina V; Nebuloni M; Pasqualini F; Latini R; Garlanda C; Mantovani A. 2008. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation 117(8):1055-64. [PubMed: 18268142]  [MGI Ref ID J:148653]

Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. [PubMed: 17122101]  [MGI Ref ID J:123100]

Satoskar AR; Okano M; Connaughton S; Raisanen-Sokolwski A; David JR; Labow M. 1998. Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice. Eur J Immunol 28(7):2066-74. [PubMed: 9692874]  [MGI Ref ID J:83038]

Saxena A; Chen W; Su Y; Rai V; Uche OU; Li N; Frangogiannis NG. 2013. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol 191(9):4838-48. [PubMed: 24078695]  [MGI Ref ID J:206237]

Schmitz N; Kurrer M; Bachmann MF; Kopf M. 2005. Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79(10):6441-8. [PubMed: 15858027]  [MGI Ref ID J:98377]

Schmitz N; Kurrer M; Kopf M. 2003. The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur J Immunol 33(4):991-1000. [PubMed: 12672065]  [MGI Ref ID J:82863]

Schultz J; Schwarz A; Neidhold S; Burwinkel M; Riemer C; Simon D; Kopf M; Otto M; Baier M. 2004. Role of interleukin-1 in prion disease-associated astrocyte activation. Am J Pathol 165(2):671-8. [PubMed: 15277240]  [MGI Ref ID J:91520]

Sporri R; Joller N; Albers U; Hilbi H; Oxenius A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol 176(10):6162-71. [PubMed: 16670325]  [MGI Ref ID J:131762]

Sutton C; Brereton C; Keogh B; Mills KH; Lavelle EC. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203(7):1685-91. [PubMed: 16818675]  [MGI Ref ID J:124398]

Szretter KJ; Gangappa S; Lu X; Smith C; Shieh WJ; Zaki SR; Sambhara S; Tumpey TM; Katz JM. 2007. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol 81(6):2736-44. [PubMed: 17182684]  [MGI Ref ID J:153325]

Thomas HE; Irawaty W; Darwiche R; Brodnicki TC; Santamaria P; Allison J; Kay TW. 2004. IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse. Diabetes 53(1):113-121. [PubMed: 14693705]  [MGI Ref ID J:87251]

Timoshanko JR; Kitching AR; Iwakura Y; Holdsworth SR; Tipping PG. 2004. Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol 164(6):1967-77. [PubMed: 15161633]  [MGI Ref ID J:91098]

Tortola L; Rosenwald E; Abel B; Blumberg H; Schafer M; Coyle AJ; Renauld JC; Werner S; Kisielow J; Kopf M. 2012. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122(11):3965-76. [PubMed: 23064362]  [MGI Ref ID J:193548]

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Wolf G; Gabay E; Tal M; Yirmiya R; Shavit Y. 2006. Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120(3):315-24. [PubMed: 16426759]  [MGI Ref ID J:112801]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Il1r1tm1Roml  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Il1r1tm1Roml x Homozygous for Il1r1tm1Roml  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Il1r1tm1Roml  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Il1r1tm1Roml x Homozygous for Il1r1tm1Roml  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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