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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6C3Fe-a/a-dep (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N37F2p Description
Mice homozygous for the {i dep} mutation can be identified at one week of age by thin, short hair. By three weeks, some mice are hairless while others develop a coat. Hair follicles are misshapen and disoriented. The coat has a matted, greasy appearance with clumps of pigment.Development
The dep mutation arose from the T tf/ tf+ stock in 1966. The stock background included an unspecified laboratory stock and approximately 50% C57BL/10Gn. In 1967 dep was crossed to C57. Although the records are not clear, it is thought that after one intercross generation, dep was crossed to CBA/Ca and then maintained as a sibling mating for 4 generations (F4). The dep mutation was then outcrossed to SEC/1 and sibling mated for 8 generations (F8). In 1971, dep was crossed to B6C3F1 a/a and maintained by an outcross/intercross strategy. In 1983, dep had been backcrossed to B6C3F1 a/a for 28 generations (N28).
Related Strains
Strains carrying a allele
View Strains carrying a (104 strains)
Phenotype
Phenotype Information
assigned by genotype
dep/dep
involves: C3HeB/FeJ * C57BL/6J
- skin/coat/nails phenotype
- abnormal coat appearance (MGI Ref ID J:20220)
- identifiable at about 1 week of age when first coat appears
- abnormal epidermal layer morphology (MGI Ref ID J:5722)
- dermal-epidermal recombination grafts of embryonic skin shows this allele acts in the epidermis
- abnormal hair follicle morphology (MGI Ref ID J:5722)
- abnormal hair follicle orientation (MGI Ref ID J:5722)
- abnormal hair growth (MGI Ref ID J:5722)
- abnormal hair cycle (MGI Ref ID J:20220)
- premature hair loss (MGI Ref ID J:20220)
- some mice are nearly hairless at 3 weeks of age; others may have a nearly normal coat
- short hair (MGI Ref ID J:5722)
- sparse hair (MGI Ref ID J:20220)
- abnormal hair medullary septa cells (MGI Ref ID J:5722)
- 20% of coat hairs show an irregular arrangement of septa or complete interruption of septa
- abnormal hair shaft melanin granules (MGI Ref ID J:20220)
- excessive accumulation and clumping of pigment in the hair
- clumps of pigment appear to be the remains of degenerating follicles
- pigmentation phenotype
- abnormal hair shaft melanin granules (MGI Ref ID J:20220)
- excessive accumulation and clumping of pigment in the hair
- clumps of pigment appear to be the remains of degenerating follicles
Genes & Alleles
Gene & Allele Information
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Allele Symbol | dep | ||
| Allele Name | depilated | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK T tf/J | ||
| Gene Symbol and Name | dep, depilated | ||
| Chromosome | 4 | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Mayer TC; Kleiman NJ; Green MC. 1976. Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics 84(1):59-65. [PubMed: 791749] [MGI Ref ID J:5722]
Rinchik EM. 1994. Molecular genetics of the brown (b)-locus region of mouse chromosome 4. II. Complementation analyses of lethal brown deletions. Genetics 137(3):855-65. [PubMed: 8088529] [MGI Ref ID J:18899]
dep relatedGreen MC. 1970. New mutant: a new recessive mutation, depilated (dep), arose in our T tf/+ tf stock in 1966. Mouse News Lett 43:31. [MGI Ref ID J:20220]
Mayer TC; Kleiman NJ; Green MC. 1976. Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics 84(1):59-65. [PubMed: 791749] [MGI Ref ID J:5722]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433] [MGI Ref ID J:43880]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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