Strain Name: |
FVB.129P2(B6)-Fmr1tm1Cgr/J |
|---|---|
Stock Number: |
003024 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Fmr1; Fmr1tm1Cgr; Pde6b; Pde6brd1; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Background Strain FVB/NJ Donor Strain B6,129P-Fmr1tm1Cgr (129P2 derived E14TG2a ES cell line) Donating Investigator IMR Colony, The Jackson Laboratory Generation N?+5F6p Appearance
albino
Related Genotype: Tyrc/TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Strain Description
Mice homozygous for the Fmr1tm1Cg targeted mutation show macroorchidism (enlarged testes), learning deficits, and hyperactivity. Macroorchidism in caused by an increased rate of Sertoli cell proliferation during embryogenesis which may be independent of FSH signalling. Comparison of homozygotes to wildtype littermates in hidden- and visible-platform water maze learning showed deficits in spatial learning and motor performance.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Fmr1tm1Cgr | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Ben Oostra | ||
| Common Name(s) | FMRP KO; Fmr1 KO; FraX; fmr-tm1Cgr; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Fmr1, fragile X mental retardation syndrome 1 homolog | ||
| Chromosome | X | ||
| Gene Common Name(s) | FMRP; FRAXA; Fmr-1; MGC87458; POF; POF1; | ||
| General Note | Genbank: AF179463 and AF170530 | ||
| Molecular Note | A neomycin resistance gene was inserted into exon 5. RT-PCR analysis on testis RNA derived from hemizygous male mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on extracts of testes, liver, kidneyand brain of hemizygous male mice confirmed that no stable encoded protein was made. [MGI Ref ID J:19220] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
| Allele | Control | |
|---|---|---|
| Fmr1tm1Cgr | 001800 FVB/NJ | |
| Considerations for Choosing Controls | ||
Fmr1tm1Cgr
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Strains carrying Fmr1tm1Cgr allele
003025 B6.129P2-Fmr1tm1Cgr/J 004624 FVB.129P2-Fmr1tm1Cgr/J 002700 FVB;129P-Fmr1tm1Cgr/J View Strains carrying Fmr1tm1Cgr (3 strains)
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
Strains carrying other alleles of Pde6b
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying other alleles of Pde6b (8 strains)
Congenic Nomenclature
Fmr1tm1Cgr related
Pde6brd1 relatedDevelopmental Biology Research
Internal/Organ Defects (multiple)
Mouse/Human Gene Homologs
fragile site mental retardation 1
Neurobiology Research
Behavioral and Learning Defects
Fragile X Mental Retardation Syndrome
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Selected Reference(s)
Additional ReferencesThe Dutch-Belgium Fragile X Consortium: Bakker CE; Verheij C; Willemsen R; Vanderhelm R; Oerlemans F; Vermey M; Bygrave A; Hoogeveen AT; Oostra BA; Reyniers E; Deboulle K; Dhooge R; Cras P; Vanvelzen D; Nagels G; Martin JJ; Dedyn PP; Darby JK; Willems PJ. 1994. Fmr1 knockout mice: a model to study fragile x mental retardation. The Dutch-Belgium Fragile X Consortium Cell 78(1):23-33. [PubMed: 8033209] [MGI Ref ID J:19220]
| Strain Name: | FVB.129P2(B6)-Fmr1tm1Cgr/J |
| Stock Number: | 003024 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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