Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.NOR-(Zfp106-Il1a)/Lt    (Changed: 17-FEB-06 ) NOD.NOR-(Zfp106-Il1a)    (Changed: 17-FEB-05 ) NOD.NOR-(Sh3bp3-Il1a)    (Changed: 15-DEC-04 ) NOD.NOR-(Zfp106-Il1a)    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/ShiLt Donor Strain NOR/Lt H2 Haplotype g7 Generation N21F37p (26-FEB-06) Generation Definitions   Donating Investigator Edward Leiter,   The Jackson Laboratory

Appearance
albino, pink eyed
Related Genotype: A/A Tyr^c/Tyr^c

Description
At 30 weeks of age, incidence of diabetes among both male and female NOD.NOR-Zfp106-Il1a (Idd13^r, Il1a^NOR)mice was significantly lower than in NOD/Lt mice, but in females was significantly higher than in NOD.NOR-D2Mit490-D2Mit144 (Idd13^r, Il1a^NOR),which carries a larger NOR/Lt-derived segment of Chr 2. At 30 weeks, 56% of female NOD.NOR-Zfp106-Il1a (Idd13^r, Il1a^NOR)mice had developed IDDM, compared to 100% of female NOD/Lt mice. By one year, IDDM incidence in females and males of the former strain had reached 62% and 25%, respectively, of that in control NOD/Lt mice. Thus, NOD.NOR-Zfp106-Il1a (Idd13^r, Il1a^NOR)retains the NOR allele(s) for "at least one, but not the complete set" of genes comprising the complex Idd13IDDM susceptibility/resistance locus.

Development
Mice of a congenic strain (at N12) carrying a defined segment of Chr 2 that included the IDDM resistant allele of NOR/Lt at the insulin dependent diabetes susceptibility locus Idd13 were further backcrossed to NOD/Lt. At backcross generation N21, the truncated NOR-derived segment of Chr 2 was fixed to homozygosity in each of three lines by sib mating. NOD.NOR-Zfp106-Il1a (Idd13^r , Il1a^NOR) carries a 6 cM interval of Chr 2 from NOR/Lt extending from Zfp106/H3a through Il1a that includes part, but not all, of the complex insulin dependent diabetes susceptibility/resistance locus Idd13. (Serreze et al. (1998) refer to this strain as NOD.H3a-Il1^NOR .)

Control Information

	Control
	001976 NOD/ShiLtJ	(approximate)
Considerations for Choosing Controls

Related Strains

Strains carrying   Idd13^NOR/Lt allele

002346	NOD.NOR-(D2Mit490-Ada)/LtJ
003051	NOD.NOR-(Il1a-Pcna)/LtJ

View Strains carrying   Idd13^NOR/Lt     (2 strains)

Strains carrying other alleles of Idd13

003064	B6.NOD-(D2Mit274-D2Mit343)/J
002346	NOD.NOR-(D2Mit490-Ada)/LtJ
003051	NOD.NOR-(Il1a-Pcna)/LtJ
002347	NOR.NOD-(Il1-Ada)/LtJ

View Strains carrying other alleles of Idd13     (4 strains)

Strains carrying other alleles of Il1a

003051

NOD.NOR-(Il1a-Pcna)/LtJ

View Strains carrying other alleles of Il1a     (1 strain)

Strains carrying other alleles of Zfp106

000422	B10.LP-H3b H13b/(36NS)Sn
000421	B10.LP-H3b/Sn

View Strains carrying other alleles of Zfp106     (2 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
      NOD/ShiLtJ Non-MHC Congenics

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Idd13NOR/Lt
Allele Name		NOR/Lt
Allele Type		QTL
Strain of Origin		NOR/Lt
Gene Symbol and Name		Idd13, insulin dependent diabetes susceptibility 13
Chromosome		2
Molecular Note		This allele confers resistance to insulin dependent diabetes compared to NOD/Lt. [MGI Ref ID J:20685]
Gene Symbol and Name		Il1a, interleukin 1 alpha
Chromosome		2
Gene Common Name(s)		IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1; Il-1a;
Gene Symbol and Name		Zfp106, zinc finger protein 106
Chromosome		2
Gene Common Name(s)		Cd-1; H3a; SH3-domain binding protein 3; SH3BP3; Sh3bp3; ZNF474; histocompatibility 3a, CTL stimulating; sirm;

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Serreze DV; Bridgett M; Chapman HD; Chen E; Richard SD; Leiter EH. 1998. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 160(3):1472-8. [PubMed: 9570569]  [MGI Ref ID J:44130]

Serreze DV; Prochazka M; Reifsnyder PC; Bridgett MM; Leiter EH. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180(4):1553-8. [PubMed: 7931087]  [MGI Ref ID J:20685]

Idd13^NOR/Lt related

Serreze DV; Bridgett M; Chapman HD; Chen E; Richard SD; Leiter EH. 1998. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 160(3):1472-8. [PubMed: 9570569]  [MGI Ref ID J:44130]

Serreze DV; Prochazka M; Reifsnyder PC; Bridgett MM; Leiter EH. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180(4):1553-8. [PubMed: 7931087]  [MGI Ref ID J:20685]

Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice. J Immunol 177(10):7033-41. [PubMed: 17082619]  [MGI Ref ID J:114754]

Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12):1313-23. [PubMed: 17982459]  [MGI Ref ID J:127760]

Zekavat G; Mozaffari R; Arias VJ; Rostami SY; Badkerhanian A; Tenner AJ; Nichols KE; Naji A; Noorchashm H. 2010. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics 62(6):397-407. [PubMed: 20387063]  [MGI Ref ID J:160373]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Type 1 Diabetes Repository collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	001976 NOD/ShiLtJ	(approximate)
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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