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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names NOD.NOR-(Il1a-Pcna)/Lt (Changed: 17-FEB-06 ) NOD.NOR-(Il1a-Pcna) (Changed: 17-FEB-05 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/ShiLt Donor Strain NOR/Lt H2 Haplotype g7 Generation N21F29p (12-FEB-06)
Generation DefinitionsDonating Investigator Edward Leiter, The Jackson Laboratory Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcDescription
At 30 weeks of age, incidence of diabetes among both male and female NOD.NOR-Il1a-Pcna (Idd13r, Il1aNOR)mice was significantly lower (for females, 62% vs.100%) than in NOD/Lt mice, but in females was significantly higher (62% vs.16%) than in NOD.NOR-D2Mit490-D2Mit144 (Idd13r, Il1aNOR),which carries a larger NOR/Lt-derived segment of Chr 2. By 46 weeks, IDDM incidence in females and males of the former strain had reached 75% and 12%, respectively, of that in control NOD/Lt mice. Thus, NOD.NOR-Il1a-Pcna (Idd13r, Il1aNOR)retains the NOR allele(s) for "at least one, but not the complete set" of genes comprising the complex Idd13IDDM susceptibility/resistance locus.Development
Mice of a congenic strain (at N12) carrying a defined segment of Chr 2 that included the IDDM resistant allele of NOR/Lt at the insulin dependent diabetes susceptibility locus Idd13 were further backcrossed to NOD/Lt. At backcross generation N21, the truncated NOR-derived segment of Chr 2 was fixed to homozygosity in each of three lines by sib mating. NOD.NOR-Il1a-Pcna (Idd13r , Il1aNOR) carries a 1.2 cM interval of Chr 2 from NOR/Lt extending from Il1a through Pcna that includes part, but not all, of the complex insulin dependent diabetes susceptibility/resistance locus Idd13. (Serreze et al. (1998) refer to this strain as NOD.Il1-PcnaNOR .)
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Idd13NOR/Lt allele
002346 NOD.NOR-(D2Mit490-Ada)/LtJ 003050 NOD.NOR-(Zfp106-Il1a)/LtJ View Strains carrying Idd13NOR/Lt (2 strains)
003064 B6.NOD-(D2Mit274-D2Mit343)/J 002346 NOD.NOR-(D2Mit490-Ada)/LtJ 003050 NOD.NOR-(Zfp106-Il1a)/LtJ 002347 NOR.NOD-(Il1-Ada)/LtJ
003050 NOD.NOR-(Zfp106-Il1a)/LtJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ Non-MHC Congenics
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | Il1a, interleukin 1 alpha | ||
|---|---|---|---|
| Chromosome | 2 | ||
| Gene Common Name(s) | IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1; Il-1a; | ||
| Gene Symbol and Name | Pcna, proliferating cell nuclear antigen | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | PCNAR; Pcna/cyclin; | ||
| Allele Symbol | Idd13NOR/Lt | ||
| Allele Name | NOR/Lt | ||
| Allele Type | QTL | ||
| Strain of Origin | NOR/Lt | ||
| Gene Symbol and Name | Idd13, insulin dependent diabetes susceptibility 13 | ||
| Chromosome | 2 | ||
References
References provided by MGI
Additional References
Serreze DV; Bridgett M; Chapman HD; Chen E; Richard SD; Leiter EH. 1998. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 160(3):1472-8. [PubMed: 9570569] [MGI Ref ID J:44130]
Serreze DV; Prochazka M; Reifsnyder PC; Bridgett MM; Leiter EH. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180(4):1553-8. [PubMed: 7931087] [MGI Ref ID J:20685]
Idd13NOR/Lt relatedSerreze DV; Bridgett M; Chapman HD; Chen E; Richard SD; Leiter EH. 1998. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 160(3):1472-8. [PubMed: 9570569] [MGI Ref ID J:44130]
Serreze DV; Prochazka M; Reifsnyder PC; Bridgett MM; Leiter EH. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180(4):1553-8. [PubMed: 7931087] [MGI Ref ID J:20685]
Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice. J Immunol 177(10):7033-41. [PubMed: 17082619] [MGI Ref ID J:114754]
Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12):1313-23. [PubMed: 17982459] [MGI Ref ID J:127760]
Zekavat G; Mozaffari R; Arias VJ; Rostami SY; Badkerhanian A; Tenner AJ; Nichols KE; Naji A; Noorchashm H. 2010. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics 62(6):397-407. [PubMed: 20387063] [MGI Ref ID J:160373]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Type 1 Diabetes Repository collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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