Strain Name:

B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ

Stock Number:

003069

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/Lt    (Changed: 01-DEC-05 )
B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)    (Changed: 17-FEB-05 )
c1c c17    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain NOD/ShiLt
H2 Haplotypeb
 
Donating InvestigatorDr. Edward Leiter,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
This strain is doubly congenic for a 19 cM segment of Chr 17 (called c17 in the reference below) extending from D17Mit21through D17Mit10and including the major histocompatibility complex, H2,and the insulin dependent diabetes susceptibility locus Idd1and for a 44 cM segment of Chr 1 (called c1c by Yui et al.)extending from D1Mit3through Bcl2(B-cell leukemia/lymphoma 2) and including Idd5(insulin dependent diabetes susceptibility 5). No information has been published for this double congenic. However, upon histologic examination of the pancreas, a significantly higher percentage of both B6.NOD-D1Mit3-Bcl2 (Idd5)and B6.NOD-D17Mit21-D17Mit10 (H2g7, Idd1)singly congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreas of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Although male and female B6.NOD-D17Mit21-D17Mit10 (H2g7, Idd1)mice exhibited similar incidence of pancreatic infiltration, B6.NOD-D1Mit3-Bcl2 (Idd5)females developed periinsulitis at twice the frequency of males. Female NOD mice are more susceptible than males to both insulitis and diabetes.

Development
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate homozygotes for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest. As evidence suggested the existence of multiple loci on Chr 1 that affect susceptibility to IDD and/or insulitis, two congenic lines were generated carrying overlapping segments of Chr 1, each including the diabetes susceptibility locus and one insulitis susceptibility locus. The B6.NOD-D1Mit3-Bcl2 D17Mit21-D17Mit10 (Idd5; H2g7 , Idd1) double congenic strain was created by crossing mice of the singly congenic B6.NOD-D17Mit21-D17Mit10 (H2g7 , Idd1) and B6.NOD-D1Mit3-Bcl2 (Idd5) strains, then breeding to homozygosity for both congenic segments.

Related Strains

View Strains carrying   H2g7     (15 strains)

View Strains carrying   Idd1NOD/Uf     (5 strains)

View Strains carrying   Idd5NOD     (4 strains)

Strains carrying other alleles of Bcl2
003082   129S1/SvImJ-Bcl2tm1Mpin/J
018430   B6.129X1(Cg)-Bcl2tm1.1Sjk/J
003062   B6.NOD-(D1Mit3-Bcl2)/J
002265   B6;129S2-Bcl2tm1Sjk/J
008882   STOCK Bcl2tm1Irt/J
View Strains carrying other alleles of Bcl2     (5 strains)

View Strains carrying other alleles of D17Mit10     (8 strains)

View Strains carrying other alleles of D17Mit21     (7 strains)

Strains carrying other alleles of D1Mit3
003062   B6.NOD-(D1Mit3-Bcl2)/J
View Strains carrying other alleles of D1Mit3     (1 strain)

Strains carrying other alleles of H2
006500   129.NOD-(D17Mit175-H2)/J
001649   A.BY H2bc H2-T18f/SnJ-Dstncorn1/J
000140   A.BY-H2bc H2-T18f/SnJ
000472   A.CA-H2f H2-T18a/SnJ
000471   A.SW-H2s H2-T18b/SnJ
001066   A.TH-H2t2/SfDvEgMobJ
001067   A.TL-H2t1/SfDvEgMobJ
002089   AK.B6-H2b Fv1b/J
002090   AK.B6-H2b/J
001094   AK.L-H2b/1CyTyJ
001095   AK.L-H2oz2/CyJ
001096   AK.L-H2oz3/CyJ
000470   AK.M-H2m H2-T18a/nSnJ
000469   B10.A-H2a H2-T18a/SgSnJ
000468   B10.A-H2h2/(2R)SgSnJ
001150   B10.A-H2h4/(4R)SgDvEgJ
001149   B10.A-H2i3/(3R)SgDvEgJ
000467   B10.A-H2i5 H2-T18a/(5R)SgSnJ
000466   B10.AKM-H2m H2-T18a/SnJ
001954   B10.AQR-H2y1/KljMcdJ
000465   B10.BR-H2k2 H2-T18a/SgSnJ
004804   B10.BR-H2k2 H2-T18a/SgSnJJrep
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
010514   B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J
006446   B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024   B10.D1-H2q/SgJ
001163   B10.D2-H2bm23/EgJ
000462   B10.D2-H2d/n2SnJ
001164   B10.D2-H2dm1/EgJ
001151   B10.D2-H2g3/(103R)EgJ
001153   B10.D2-H2i7/(107R)EgJ
001152   B10.D2-H2ia/(106R)EgJ
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000463   B10.D2-Hc1 H2d H2-T18c/nSnJ
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
000464   B10.DA-H2qp1 H2-T18b/(80NS)SnJ
001823   B10.F-H2bp5/(14R)J
001818   B10.F-H2pb1/(13R)J
001012   B10.HTG-H2g/2CyJ
000999   B10.HTG-H2g/3CyJ
001894   B10.LG-H2ar1/J
000459   B10.M-H2f H2-T18a?/SnJ
002225   B10.M-H2f/nMob Fmn1ld-2J/J
001068   B10.M-H2f/nMobJ
000739   B10.M-H2fm2/MobJ
001154   B10.MBR-H2bq1/SxEgJ
001825   B10.P-H2kp1/(10R)SgJ
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
000458   B10.PL-H2u H2-T18a/(73NS)SnJ
000457   B10.RIII-H2r H2-T18b/(71NS)SnJ
001069   B10.RIII-H2r/(71NS)nMobJ
001760   B10.S-H2as1/(8R)/J
001953   B10.S-H2s/SgMcdJ
001817   B10.S-H2sm1/(12R)SgJ
001650   B10.S-H2t4/(9R)/J
000456   B10.SM H2v H2-T18b/(70NS)Sn-cw/J
001155   B10.T-H2y2/(6R)SgDvEgJ
000445   B10.WB-H2j H2-T18b/SnJ
000444   B10.Y-H2pa H2-T18c/SnJ
003483   B6 x B10.D1-H2q/SgJ-Nox3het-2J/J
003561   B6 x B10.PL-H2u/(73NS)Sn-Hxl/J
002995   B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J
003584   B6.129S2-H2dlAb1-Ea/J
001148   B6.AK-H2k/FlaEgJ
001895   B6.AK-H2k/J
001160   B6.C-H2bm10/KhEgJ
001161   B6.C-H2bm11/KhEgJ
000364   B6.C-H2bm2/ByJ
000369   B6.C-H2bm4/ByJ
001158   B6.C-H2bm7/KhEgJ
000360   B6.C-H2d Mdmg1BALB/cBy/aByJ
000359   B6.C-H2d/bByJ
001429   B6.C-H2g6/J
007958   B6.Cg-H2b3/FlaCmwJ
007959   B6.Cg-H2b4/FlaCmwJ
000944   B6.SJL-H2b C3c/2CyJ
000966   B6.SJL-H2s C3c/1CyJ
000945   B6.SW/1CyJ
003374   B6;129S2-H2dlAb1-Ea/J
003240   B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
002844   BALB.5R-H2i5/LilJ
001165   BALB/c-H2dm2/KhEgJ
001041   BKS.B6-H2b/J
001892   BRVR.B10-H2b/J
001893   BRVR.D2-H2d/J
002845   C.B-H2b Tg(H2-Dd)D8Gja/LilJ
001952   C.B10-H2b/LilMcdJ
001768   C3.Cg-Irs1Sml H2b/GrsrJ
000443   C3.HTG-H2g H2-T18b?/SnJ
000441   C3.JK-H2j H2-T18b/SnJ
000440   C3.LG-H2ar1/CkcCyJ
000439   C3.NB-H2p H2-T18c?/SnJ
000438   C3.SW-H2b/SnJ
000473   C3H-H2o2 C4bb/SfSnJ
001156   C57BL/6J-H2bm3/EgJ
001157   C57BL/6Kh-H2bm5/KhEgJ
000437   D1.C-H2d H2-T18c/SnJ
000436   D1.DA-H2qp1/SnJ
000435   D1.LP-H2b H2-T18b?/SnJ
000434   LP.RIII-H2r H2-T18b/SnJ
001382   LT.MA-Glo1b H2d/J
001383   LT.MA-Glo1b H2k/J
002591   NOD.B10Sn-H2b/J
026243   NOD.Cg-(D9rs4135590-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
026624   NOD.Cg-(D9rs6385855-D9rs13480186)H2k2Tg(ILK3mHEL)3Ccg Tg(TcrHEL3A9)1Mmd/SlsgJ
006935   NOD.Cg-H2b thnh/J
004447   NOD.Cg-H2h4/DilTacUmmJ
001626   NOD.NON-H2nb1/LtJ
002032   NOD.SW-H2q/J
001308   STOCK H2473a/J
003154   WLC.C-H2d/MorJ
003153   WLC.Cg-H2d Mtv2a/MorJ
View Strains carrying other alleles of H2     (118 strains)

Strains carrying other alleles of Idd1
006500   129.NOD-(D17Mit175-H2)/J
010972   B10.NOD-(rs13459151-rs13483054)/1107MrkJ
004309   NOD.ALR-(D17Mit16-D17Mit10)/LtJ
004308   NOD.ALR-(D17Mit16-H2-D)/LtJ
View Strains carrying other alleles of Idd1     (4 strains)

View Strains carrying other alleles of Idd5     (6 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity

H2g7 related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Idd5NOD related

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
      NOD/ShiLtJ MHC Congenics

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

 
Gene Symbol and Name Bcl2, B cell leukemia/lymphoma 2
Chromosome 1
Gene Common Name(s) AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik; PPP1R50; RIKEN cDNA C430015F12 gene; RIKEN cDNA D630044D05 gene; RIKEN cDNA D830018M01 gene; expressed sequence AW986256;
 
Gene Symbol and Name D1Mit3, DNA segment, Chr 1, Massachusetts Institute of Technology 3
Chromosome 1
 
Gene Symbol and Name D17Mit10, DNA segment, Chr 17, Massachusetts Institute of Technology 10
Chromosome 17
 
Gene Symbol and Name D17Mit21, DNA segment, Chr 17, Massachusetts Institute of Technology 21
Chromosome 17
 
Allele Symbol H2g7
Allele Name g7 variant
Allele Type Not Applicable
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
 
Allele Symbol Idd1NOD/Uf
Allele Name NOD/Uf
Allele Type QTL
Strain of OriginNOD/Uf
Gene Symbol and Name Idd1, insulin dependent diabetes susceptibility 1
Chromosome 17
Gene Common Name(s) Idd-1;
General Note NOD is homozygous for recessive alleles for susceptibility at all three loci, Idd1s, Idd2s, and Idd3s. The dominant alleles for non-susceptibility to IDD, Idd1r, etc., occur in the NON strain. Homozygosity for the recessive alleles at all three loci is necessary for the development of IDD.The Idd1 locus is linked to the major histocompatibility locus on Chr 17, but Idd2 is on Chr 9 (1) and Idd3 is on Chr 3 (J:8783, J:3351).

This locus is also linked to peripheral CD4 lymphocytosis.

Molecular Note This allele confers increased periinsulitis and increased CD4 lymphocytosis compared to C57BL/6. [MGI Ref ID J:33172]
 
Allele Symbol Idd5NOD
Allele Name NOD
Allele Type QTL
Strain of OriginNOD
Gene Symbol and Name Idd5, insulin dependent diabetes susceptibility 5
Chromosome 1
Gene Common Name(s) Idd-5;
Molecular Note This allele confers susceptibility to insulin dependent diabetes compared to C57BL/10. [MGI Ref ID J:71276]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Lamhamedi-Cherradi SE; Boulard O; Gonzalez C; Kassis N; Damotte D; Eloy L; Fluteau G; Levi-Strauss M; Garchon HJ. 2001. Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice. Diabetes 50(12):2874-8. [PubMed: 11723074]  [MGI Ref ID J:72900]

Yui MA; Muralidharan K; Moreno-Altamirano B; Perrin G; Chestnut K; Wakeland EK. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome 7(5):331-4. [PubMed: 8661724]  [MGI Ref ID J:33172]

H2g7 related

Auger JL; Haasken S; Steinert EM; Binstadt BA. 2012. Incomplete TCR-beta allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol 42(9):2354-62. [PubMed: 22706882]  [MGI Ref ID J:187944]

Bassi EJ; Moraes-Vieira PM; Moreira-Sa CS; Almeida DC; Vieira LM; Cunha CS; Hiyane MI; Basso AS; Pacheco-Silva A; Camara NO. 2012. Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Diabetes 61(10):2534-45. [PubMed: 22688334]  [MGI Ref ID J:208536]

Belizaire R; Unanue ER. 2009. Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A 106(41):17463-8. [PubMed: 19805168]  [MGI Ref ID J:153672]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue ER. 1996. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156(2):450-8. [PubMed: 8543793]  [MGI Ref ID J:30538]

Choisy-Rossi CM; Holl TM; Pierce MA; Chapman HD; Serreze DV. 2004. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol 173(6):3791-800. [PubMed: 15356126]  [MGI Ref ID J:167508]

Driver JP; Chen YG; Zhang W; Asrat S; Serreze DV. 2011. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 60(4):1354-9. [PubMed: 21307079]  [MGI Ref ID J:171763]

Driver JP; Scheuplein F; Chen YG; Grier AE; Wilson SB; Serreze DV. 2010. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes 59(2):423-32. [PubMed: 19903740]  [MGI Ref ID J:164162]

Ferreira C; Singh Y; Furmanski AL; Wong FS; Garden OA; Dyson J. 2009. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A 106(20):8320-5. [PubMed: 19359477]  [MGI Ref ID J:148537]

Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. [PubMed: 10449528]  [MGI Ref ID J:108724]

Fousteri G; Jasinski J; Dave A; Nakayama M; Pagni P; Lambolez F; Juntti T; Sarikonda G; Cheng Y; Croft M; Cheroutre H; Eisenbarth G; von Herrath M. 2012. Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes 61(5):1169-79. [PubMed: 22403296]  [MGI Ref ID J:196727]

Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. [PubMed: 17908938]  [MGI Ref ID J:126040]

Haasken S; Auger JL; Taylor JJ; Hobday PM; Goudy BD; Titcombe PJ; Mueller DL; Binstadt BA. 2013. Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration. J Immunol 191(3):1055-62. [PubMed: 23794629]  [MGI Ref ID J:205440]

Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066]  [MGI Ref ID J:111874]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984]  [MGI Ref ID J:7097]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509]  [MGI Ref ID J:36815]

Lee JS; Scandiuzzi L; Ray A; Wei J; Hofmeyer KA; Abadi YM; Loke P; Lin J; Yuan J; Serreze DV; Allison JP; Zang X. 2012. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 189(8):4165-74. [PubMed: 22972920]  [MGI Ref ID J:190522]

Lee MS; Mueller R; Wicker LS; Peterson LB; Sarvetnick N. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med 183(6):2663-8. [PubMed: 8676087]  [MGI Ref ID J:153576]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin.  [MGI Ref ID J:110093]

Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138]  [MGI Ref ID J:138230]

Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718]  [MGI Ref ID J:108722]

Ma YD; Park C; Zhao H; Oduro KA Jr; Tu X; Long F; Allen PM; Teitelbaum SL; Choi K. 2009. Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model. Blood 114(20):4402-10. [PubMed: 19759358]  [MGI Ref ID J:154922]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156]  [MGI Ref ID J:46553]

Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741]  [MGI Ref ID J:146982]

Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. [PubMed: 14662903]  [MGI Ref ID J:86926]

Martinez RJ; Zhang N; Thomas SR; Nandiwada SL; Jenkins MK; Binstadt BA; Mueller DL. 2012. Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol 188(1):170-81. [PubMed: 22124124]  [MGI Ref ID J:180819]

Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997]  [MGI Ref ID J:109845]

Perera J; Meng L; Meng F; Huang H. 2013. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc Natl Acad Sci U S A 110(42):17011-6. [PubMed: 24082098]  [MGI Ref ID J:202000]

Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054]  [MGI Ref ID J:14178]

Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141]  [MGI Ref ID J:33688]

Suwanai H; Wilcox MA; Mathis D; Benoist C. 2010. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A 107(20):9305-10. [PubMed: 20439722]  [MGI Ref ID J:160284]

Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 209(11):2065-77. [PubMed: 23071255]  [MGI Ref ID J:190897]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. [PubMed: 19119026]  [MGI Ref ID J:143728]

Wang JX; Bair AM; King SL; Shnayder R; Huang YF; Shieh CC; Soberman RJ; Fuhlbrigge RC; Nigrovic PA. 2012. Ly6G ligation blocks recruitment of neutrophils via a beta2-integrin-dependent mechanism. Blood 120(7):1489-98. [PubMed: 22661700]  [MGI Ref ID J:189105]

Wei J; Loke P; Zang X; Allison JP. 2011. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med 208(8):1683-94. [PubMed: 21727190]  [MGI Ref ID J:177612]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204]  [MGI Ref ID J:109830]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579]  [MGI Ref ID J:132764]

Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. [PubMed: 17267595]  [MGI Ref ID J:119749]

Idd1NOD/Uf related

Koarada S; Wu Y; Yim YS; Wakeland EW; Ridgway WM. 2004. Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics 56(5):333-7. [PubMed: 15309345]  [MGI Ref ID J:92304]

Prochazka M; Leiter EH; Serreze DV; Coleman DL. 1987. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice [published erratum appears in Science 1988 Nov 11;242(4880):945] Science 237(4812):286-9. [PubMed: 2885918]  [MGI Ref ID J:8783]

Todd JA; Aitman TJ; Cornall RJ; Ghosh S; Hall JR; Hearne CM; Knight AM; Love JM; McAleer MA; Prins JB; Rodrigues N; Lathrop M; Pressey A; DeLarato NH; Peterson LB; Wicker LS. 1991. Genetic analysis of autoimmune type 1 diabetes mellitus in mice [see comments] Nature 351(6327):542-7. [PubMed: 1675432]  [MGI Ref ID J:3351]

Yui MA; Muralidharan K; Moreno-Altamirano B; Perrin G; Chestnut K; Wakeland EK. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome 7(5):331-4. [PubMed: 8661724]  [MGI Ref ID J:33172]

Idd5NOD related

Brayer J; Lowry J; Cha S; Robinson CP; Yamachika S; Peck AB; Humphreys-Beher MG. 2000. Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol 27(8):1896-904. [PubMed: 10955330]  [MGI Ref ID J:71276]

Cornall RJ. 1993. Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus. Clin Sci (Colch) 84(3):257-62. [PubMed: 8384947]  [MGI Ref ID J:17906]

Motta V; Lejon K; Holmberg D. 2007. The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells. J Autoimmun 28(4):216-23. [PubMed: 17449224]  [MGI Ref ID J:125098]

Nguyen CQ; Kim H; Cornelius JG; Peck AB. 2007. Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. J Immunol 179(4):2318-29. [PubMed: 17675493]  [MGI Ref ID J:151221]

Nguyen CQ; Sharma A; She JX; McIndoe RA; Peck AB. 2009. Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjogren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Exp Eye Res 88(3):398-409. [PubMed: 19103199]  [MGI Ref ID J:146559]

Nguyen CQ; Yin H; Lee BH; Chiorini JA; Peck AB. 2011. IL17: potential therapeutic target in Sjogren's syndrome using adenovirus-mediated gene transfer. Lab Invest 91(1):54-62. [PubMed: 20856230]  [MGI Ref ID J:167186]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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