Strain Name:

STOCK Ptch1tm1Mps/J

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Common Names: ptc-lacz;    
In this reporter targeted mutant strain a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2 of the Ptch1 (patched homolog 1) gene. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice.


Strain Information

Former Names B6;129-Ptch1tm1Mps/J    (Changed: 08-MAY-06 )
B6;129-Ptchtm1Mps/J    (Changed: 15-DEC-04 )
Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating System+/+ sibling x Heterozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+N1F18 (17-JUN-15)
Generation Definitions
Donating InvestigatorDr. Matthew Scott,   Stanford University School of Medicine

black or dilute grey
Related Genotype: a/a Myo5ad/?

Important Note
This strain is segregating the coat color allele dilute (Myo5ad). Mice can be either black or dilute grey.

Mice homozygous for the targeted mutation die during embryogenesis and are found to have open and overgrown neural tubes. Heterozygous patched mice are larger than wild-type littermates and have a low incidence of hindlimb defects. Some heterozygotes develop brain tumors beginning around 5 weeks of age. Heterozygotes express lacZ in a pattern mimicking endogenous gene expression pattern. Homozygous embryos display derepressed lacZ expression starting at embryonic day 8.0.

A targeting vector, KO1, containing sequence encoding nuclear localized beta-galactosidase (lacZ), neomycin resistance gene, mouse protamine 1 (mP1) intron, and a polyadenylation site was electroporated into 129-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric male mice were then mated to B6D2F1 females.

Control Information

   Wild-type from the colony
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Ptch1
001430   B6C3Fe a/a-Ptch1mes/J
012457   B6N.129-Ptch1tm1Hahn/J
View Strains carrying other alleles of Ptch1     (2 strains)

Additional Web Information

JAX® NOTES, Spring 2003; 489. Medulloblastoma Mouse Models.


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Basal Cell Nevus Syndrome; BCNS
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Medulloblastoma; MDB
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Basal Cell Carcinoma, Susceptibility to, 1; BCC1   (PTCH1)
Holoprosencephaly 7; HPE7   (PTCH1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


        involves: 129S1/Sv *129X1/SvJ * Swiss Webster
  • mortality/aging
  • complete embryonic lethality during organogenesis
    • no homozygous embryos are recovered at E10.5 from intercrosses of double heterozygous Gli2, Ptc mice   (MGI Ref ID J:79392)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S1/Sv * 129X1/SvJ * C57BL/6
  • mortality/aging
  • premature death
    • with increasing age (>12 months), Ptch1-heterozygous, Ptch2-sufficient mice are less healthy and die with no obvious tumor burden   (MGI Ref ID J:112118)
    • median survival of mutants that only develop medulloblastoma is 158 days   (MGI Ref ID J:205254)
  • tumorigenesis
  • increased tumor incidence
    • 14.3% of mutants develop other tumors, including hemangiosarcomas, intestinal tumors, rhabdomyosarcomas, and lymphomas   (MGI Ref ID J:205254)
    • increased gastrointestinal tumor incidence   (MGI Ref ID J:205254)
    • increased hemangiosarcoma incidence   (MGI Ref ID J:205254)
    • increased lymphoma incidence   (MGI Ref ID J:205254)
    • increased medulloblastoma incidence
      • 42.8% of mutants develop medulloblastoma   (MGI Ref ID J:205254)
      • medulloblastomas are noninvasive and exhibit histologic patterns that mimic different phenotypes seen in human medulloblastoma, including classic biphasic phenotype and anaplastic variants   (MGI Ref ID J:205254)
    • increased rhabdomyosarcoma incidence   (MGI Ref ID J:205254)
  • nervous system phenotype
  • abnormal cerebellar molecular layer
    • 1 month old cerebella show preneoplastic lesions in the outer molecular layer where progenitors within the external germinal layer previously resided, suggesting that medulloblastomas arise from granule neuron progenitors   (MGI Ref ID J:205254)


        involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
  • tumorigenesis
  • increased tumor incidence
    • soft tissue tumors   (MGI Ref ID J:42441)
    • increased medulloblastoma incidence
      • tumors arise as early as 5 weeks of age and increase in severity and frequency with age   (MGI Ref ID J:42441)
  • growth/size/body region phenotype
  • increased body size   (MGI Ref ID J:42441)
  • limbs/digits/tail phenotype
  • polydactyly
    • seen in a small fraction of heterozygotes   (MGI Ref ID J:42441)
  • syndactyly
    • seen in a small fraction of heterozygotes   (MGI Ref ID J:42441)


        involves: 129S1/Sv * 129X1/SvJ
  • tumorigenesis
  • increased medulloblastoma incidence   (MGI Ref ID J:102702)
    • low incidence in around 10% of mice   (MGI Ref ID J:114992)
    • 15-20% of mice develop medulloblastomas   (MGI Ref ID J:144811)
    • tumors consist of small round cells with little cytoplasm and clearly demarcated borders   (MGI Ref ID J:144811)
    • 100% of immunocompromised hosts receiving >200,000 tumor cells will develop medulloblastomas with a mean latency of 49 days   (MGI Ref ID J:144811)
    • tumor cells expressing CD15+ have the characteristics of cancer stem cells including high rates of proliferation and ability to propagate the disease into immunocompromised hosts   (MGI Ref ID J:144811)
  • increased rhabdomyosarcoma incidence
    • low incidence in around 10% of mice   (MGI Ref ID J:114992)
  • increased skin tumor incidence
    • mutants develop small tumor foci/buds in the skin; these epithelial invaginations arise from both the hair follicle and the interfollicular epithelium   (MGI Ref ID J:82653)
    • tumor buds appear at the first postnatal anagen stage   (MGI Ref ID J:82653)
  • integument phenotype
  • focal hair loss
    • small foci of hair loss are observed, each one in association with epithelial invaginations   (MGI Ref ID J:82653)
  • increased skin tumor incidence
    • mutants develop small tumor foci/buds in the skin; these epithelial invaginations arise from both the hair follicle and the interfollicular epithelium   (MGI Ref ID J:82653)
    • tumor buds appear at the first postnatal anagen stage   (MGI Ref ID J:82653)


        Background Not Specified
  • behavior/neurological phenotype
  • decreased grip strength   (MGI Ref ID J:165965)
  • other phenotype
  • other aberrant phenotype   (MGI Ref ID J:165965)


        involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
  • mortality/aging
  • complete embryonic lethality
    • embryos die between E9.0 and E10.5   (MGI Ref ID J:42441)
  • nervous system phenotype
  • open neural tube
    • neural tube fails to close completely and is overgrown in the head folds, hindbrain, and spinal cord   (MGI Ref ID J:42441)
  • cardiovascular system phenotype
  • abnormal heart development
    • heart is not properly formed   (MGI Ref ID J:42441)
  • embryogenesis phenotype
  • open neural tube
    • neural tube fails to close completely and is overgrown in the head folds, hindbrain, and spinal cord   (MGI Ref ID J:42441)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ptch1tm1Mps related

Cancer Research
Increased Tumor Incidence
      Other Tissues/Organs
      Other Tissues/Organs: brain
Tumor Suppressor Genes

Developmental Biology Research
Embryonic Lethality (Homozygous)
Neural Tube Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Ptch1tm1Mps
Allele Name targeted mutation 1, Matthew P Scott
Allele Type Targeted (Null/Knockout, Reporter)
Common Name(s) LacZ/Ptc; Ptc1-lacZ; Ptc1-; Ptc1lzki; PtclacZ; Ptcn; Ptch-; Ptch1-; Ptch1-lacZ; PtchKO1; PtchlacZ; ptc-; ptc-lacZ;
Mutation Made ByDr. Matthew Scott,   Stanford University School of Medicine
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Ptch1, patched homolog 1
Chromosome 13
Gene Common Name(s) A230106A15Rik; BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11; Patched 1; Ptch2; RIKEN cDNA A230106A15 gene; mes; mesenchymal dysplasia;
Molecular Note A construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice. [MGI Ref ID J:42441]


Genotyping Information

Genotyping Protocols

Ptchtm1Mps, MELT
Ptchtm1Mps, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Goodrich LV; Milenkovic L; Higgins KM; Scott MP. 1997. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277(5329):1109-13. [PubMed: 9262482]  [MGI Ref ID J:42441]

Additional References

Hamed S; LaRue H; Hovington H; Girard J; Jeannotte L; Latulippe E; Fradet Y. 2004. Accelerated induction of bladder cancer in patched heterozygous mutant mice. Cancer Res 64(6):1938-42. [PubMed: 15026327]  [MGI Ref ID J:89149]

Jeong Y; Epstein DJ. 2003. Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node. Development 130(16):3891-902. [PubMed: 12835403]  [MGI Ref ID J:84605]

Lewis MT; Ross S; Strickland PA; Sugnet CW; Jimenez E; Scott MP; Daniel CW. 1999. Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development 126(22):5181-93. [PubMed: 10529434]  [MGI Ref ID J:42408]

Makino S; Masuya H; Ishijima J; Yada Y; Shiroishi T. 2001. A Spontaneous Mouse Mutation, mesenchymal dysplasia (mes), Is Caused by a Deletion of the Most C-Terminal Cytoplasmic Domain of patched (ptc). Dev Biol 239(1):95-106. [PubMed: 11784021]  [MGI Ref ID J:72380]

Milenkovic L; Goodrich LV; Higgins KM; Scott MP. 1999. Mouse patched1 controls body size determination and limb patterning. Development 126(20):4431-40. [PubMed: 10498679]  [MGI Ref ID J:56195]

Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. [PubMed: 15305287]  [MGI Ref ID J:91723]

Ptch1tm1Mps related

Ahn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137(19):3221-31. [PubMed: 20724449]  [MGI Ref ID J:168361]

Allen BL; Tenzen T; McMahon AP. 2007. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 21(10):1244-57. [PubMed: 17504941]  [MGI Ref ID J:121553]

Aoto K; Shikata Y; Imai H; Matsumaru D; Tokunaga T; Shioda S; Yamada G; Motoyama J. 2009. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol 327(1):106-20. [PubMed: 19103193]  [MGI Ref ID J:145732]

Aoto K; Trainor PA. 2015. Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival. Hum Mol Genet 24(3):698-713. [PubMed: 25292199]  [MGI Ref ID J:218093]

Asai J; Takenaka H; Kusano KF; Ii M; Luedemann C; Curry C; Eaton E; Iwakura A; Tsutsumi Y; Hamada H; Kishimoto S; Thorne T; Kishore R; Losordo DW. 2006. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113(20):2413-24. [PubMed: 16702471]  [MGI Ref ID J:122447]

Ayrault O; Godeny MD; Dillon C; Zindy F; Fitzgerald P; Roussel MF; Beere HM. 2009. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A 106(40):17037-42. [PubMed: 19805107]  [MGI Ref ID J:153693]

Ayrault O; Zhao H; Zindy F; Qu C; Sherr CJ; Roussel MF. 2010. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res 70(13):5618-27. [PubMed: 20516124]  [MGI Ref ID J:161624]

Ayrault O; Zindy F; Rehg J; Sherr CJ; Roussel MF. 2009. Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma. Mol Cancer Res 7(1):33-40. [PubMed: 19147535]  [MGI Ref ID J:205254]

Bai CB; Auerbach W; Lee JS; Stephen D; Joyner AL. 2002. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129(20):4753-61. [PubMed: 12361967]  [MGI Ref ID J:79392]

Barakat MT; Humke EW; Scott MP. 2013. Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis 34(6):1382-92. [PubMed: 23389290]  [MGI Ref ID J:198323]

Bazzi H; Anderson KV. 2014. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A 111(15):E1491-500. [PubMed: 24706806]  [MGI Ref ID J:208632]

Becher OJ; Hambardzumyan D; Fomchenko EI; Momota H; Mainwaring L; Bleau AM; Katz AM; Edgar M; Kenney AM; Cordon-Cardo C; Blasberg RG; Holland EC. 2008. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res 68(7):2241-9. [PubMed: 18381430]  [MGI Ref ID J:133329]

Behesti H; Bhagat H; Dubuc AM; Taylor MD; Marino S. 2013. Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation. Dis Model Mech 6(1):49-63. [PubMed: 23065639]  [MGI Ref ID J:193730]

Berbari NF; Kin NW; Sharma N; Michaud EJ; Kesterson RA; Yoder BK. 2011. Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360(1):66-76. [PubMed: 21945076]  [MGI Ref ID J:178483]

Berman DM; Karhadkar SS; Hallahan AR; Pritchard JI; Eberhart CG; Watkins DN; Chen JK; Cooper MK; Taipale J; Olson JM; Beachy PA. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297(5586):1559-61. [PubMed: 12202832]  [MGI Ref ID J:79798]

Black GC; Mazerolle CJ; Wang Y; Campsall KD; Petrin D; Leonard BC; Damji KF; Evans DG; McLeod D; Wallace VA. 2003. Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development. Hum Mol Genet 12(24):3269-76. [PubMed: 14570707]  [MGI Ref ID J:129156]

Bouldin CM; Gritli-Linde A; Ahn S; Harfe BD. 2010. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A 107(12):5489-94. [PubMed: 20212115]  [MGI Ref ID J:158689]

Bren-Mattison Y; Hausburg M; Olwin BB. 2011. Growth of limb muscle is dependent on skeletal-derived Indian hedgehog. Dev Biol 356(2):486-95. [PubMed: 21683695]  [MGI Ref ID J:175458]

Briggs KJ; Corcoran-Schwartz IM; Zhang W; Harcke T; Devereux WL; Baylin SB; Eberhart CG; Watkins DN. 2008. Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev 22(6):770-85. [PubMed: 18347096]  [MGI Ref ID J:132980]

Brownell I; Guevara E; Bai CB; Loomis CA; Joyner AL. 2011. Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. Cell Stem Cell 8(5):552-65. [PubMed: 21549329]  [MGI Ref ID J:205656]

Cain JE; Islam E; Haxho F; Chen L; Bridgewater D; Nieuwenhuis E; Hui CC; Rosenblum ND. 2009. GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One 4(10):e7313. [PubMed: 19809516]  [MGI Ref ID J:154102]

Camp D; Haitian He B; Li S; Althaus IW; Holtz AM; Allen BL; Charron F; van Meyel DJ. 2014. Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development 141(20):3879-88. [PubMed: 25231763]  [MGI Ref ID J:217507]

Caparros-Martin JA; Valencia M; Reytor E; Pacheco M; Fernandez M; Perez-Aytes A; Gean E; Lapunzina P; Peters H; Goodship JA; Ruiz-Perez VL. 2012. The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. Hum Mol Genet :. [PubMed: 23026747]  [MGI Ref ID J:188176]

Caspary T; Garcia-Garcia MJ; Huangfu D; Eggenschwiler JT; Wyler MR; Rakeman AS; Alcorn HL; Anderson KV. 2002. Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol 12(18):1628-32. [PubMed: 12372258]  [MGI Ref ID J:79027]

Chamberlain CE; Jeong J; Guo C; Allen BL; McMahon AP. 2008. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 135(6):1097-106. [PubMed: 18272593]  [MGI Ref ID J:132152]

Chen MH; Wilson CW; Li YJ; Law KK; Lu CS; Gacayan R; Zhang X; Hui CC; Chuang PT. 2009. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev 23(16):1910-28. [PubMed: 19684112]  [MGI Ref ID J:151923]

Christopher KJ; Wang B; Kong Y; Weatherbee SD. 2012. Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Dev Biol 368(2):382-92. [PubMed: 22698544]  [MGI Ref ID J:186552]

Chuang PT; Kawcak T; McMahon AP. 2003. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 17(3):342-7. [PubMed: 12569124]  [MGI Ref ID J:81798]

Clark AM; Garland KK; Russell LD. 2000. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type leydig cells and normal development of peritubular cells and seminiferous tubules Biol Reprod 63(6):1825-38. [PubMed: 11090455]  [MGI Ref ID J:65900]

Colnot C; de la Fuente L; Huang S; Hu D; Lu C; St-Jacques B; Helms JA. 2005. Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132(5):1057-67. [PubMed: 15689378]  [MGI Ref ID J:97179]

Corcoran RB; Bachar Raveh T; Barakat MT; Lee EY; Scott MP. 2008. Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res 68(21):8788-95. [PubMed: 18974121]  [MGI Ref ID J:140638]

Corcoran RB; Scott MP. 2001. A mouse model for medulloblastoma and basal cell nevus syndrome. J Neurooncol 53(3):307-18. [PubMed: 11718263]  [MGI Ref ID J:73000]

Corno D; Pala M; Cominelli M; Cipelletti B; Leto K; Croci L; Barili V; Brandalise F; Melzi R; Di Gregorio A; Sergi LS; Politi LS; Piemonti L; Bulfone A; Rossi P; Rossi F; Consalez GG; Poliani PL; Galli R. 2012. Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification. Cancer Discov 2(6):554-68. [PubMed: 22628409]  [MGI Ref ID J:193066]

Corrales JD; Blaess S; Mahoney EM; Joyner AL. 2006. The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133(9):1811-21. [PubMed: 16571625]  [MGI Ref ID J:108507]

Cui C; Chatterjee B; Lozito TP; Zhang Z; Francis RJ; Yagi H; Swanhart LM; Sanker S; Francis D; Yu Q; San Agustin JT; Puligilla C; Chatterjee T; Tansey T; Liu X; Kelley MW; Spiliotis ET; Kwiatkowski AV; Tuan R; Pazour GJ; Hukriede NA; Lo CW. 2013. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol 11(11):e1001720. [PubMed: 24302887]  [MGI Ref ID J:205269]

Daane JM; Downs KM. 2011. Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis. Dev Dyn 240(9):2175-93. [PubMed: 22016185]  [MGI Ref ID J:177484]

Dakubo GD; Mazerolle CJ; Wallace VA. 2006. Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 79(3):221-7. [PubMed: 16598417]  [MGI Ref ID J:115750]

De Bortoli M; Castellino RC; Skapura DG; Shen JJ; Su JM; Russell HV; Hicks MJ; Man TK; Kim JY. 2007. Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. Eur J Cancer 43(8):1308-1317. [PubMed: 17467979]  [MGI Ref ID J:121824]

Dennis JF; Kurosaka H; Iulianella A; Pace J; Thomas N; Beckham S; Williams T; Trainor PA. 2012. Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet 8(10):e1002927. [PubMed: 23055936]  [MGI Ref ID J:190013]

DiPaola CP; Farmer JC; Manova K; Niswander LA. 2005. Molecular signaling in intervertebral disk development. J Orthop Res 23(5):1112-9. [PubMed: 15936916]  [MGI Ref ID J:103007]

Dierks C; Beigi R; Guo GR; Zirlik K; Stegert MR; Manley P; Trussell C; Schmitt-Graeff A; Landwerlin K; Veelken H; Warmuth M. 2008. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 14(3):238-49. [PubMed: 18772113]  [MGI Ref ID J:141160]

Dijkgraaf GJ; Alicke B; Weinmann L; Januario T; West K; Modrusan Z; Burdick D; Goldsmith R; Robarge K; Sutherlin D; Scales SJ; Gould SE; Yauch RL; de Sauvage FJ. 2011. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 71(2):435-44. [PubMed: 21123452]  [MGI Ref ID J:168107]

Dixit R; Ai X; Fine A. 2013. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development 140(21):4398-406. [PubMed: 24130328]  [MGI Ref ID J:204973]

Dutka T; Hallberg D; Reeves RH. 2015. Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice. Mech Dev 135:68-80. [PubMed: 25511459]  [MGI Ref ID J:217683]

Engevik AC; Feng R; Yang L; Zavros Y. 2013. The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology 154(12):4627-39. [PubMed: 24092639]  [MGI Ref ID J:204594]

Ernest S; Christensen B; Gilfix BM; Mamer OA; Hosack A; Rodier M; Colmenares C; McGrath J; Bale A; Balling R; Sankoff D; Rosenblatt DS; Nadeau JH. 2002. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome 13(5):259-67. [PubMed: 12016514]  [MGI Ref ID J:76559]

Fabian SL; Penchev RR; St-Jacques B; Rao AN; Sipila P; West KA; McMahon AP; Humphreys BD. 2012. Hedgehog-Gli Pathway Activation during Kidney Fibrosis. Am J Pathol 180(4):1441-53. [PubMed: 22342522]  [MGI Ref ID J:182155]

Faria CC; Golbourn BJ; Dubuc AM; Remke M; Diaz RJ; Agnihotri S; Luck A; Sabha N; Olsen S; Wu X; Garzia L; Ramaswamy V; Mack SC; Wang X; Leadley M; Reynaud D; Ermini L; Post M; Northcott PA; Pfister SM; Croul SE; Kool M; Korshunov A; Smith CA; Taylor MD; Rutka JT. 2015. Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res 75(1):134-46. [PubMed: 25391241]  [MGI Ref ID J:219650]

Fendrich V; Esni F; Garay MV; Feldmann G; Habbe N; Jensen JN; Dor Y; Stoffers D; Jensen J; Leach SD; Maitra A. 2008. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135(2):621-31. [PubMed: 18515092]  [MGI Ref ID J:141804]

Feng W; Choi I; Clouthier DE; Niswander L; Williams T. 2013. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis 51(10):677-89. [PubMed: 23897749]  [MGI Ref ID J:204468]

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Moshiri A; Reh TA. 2004. Persistent progenitors at the retinal margin of ptc+/- mice. J Neurosci 24(1):229-37. [PubMed: 14715955]  [MGI Ref ID J:87387]

Motoyama J; Milenkovic L; Iwama M; Shikata Y; Scott MP; Hui CC. 2003. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol 259(1):150-61. [PubMed: 12812795]  [MGI Ref ID J:84056]

Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource. 2010. Obtaining and Loading Phenotype Annotations from Europhenome Database Release :.  [MGI Ref ID J:165965]

Nielsen CM; Dymecki SM. 2010. Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol 340(2):430-7. [PubMed: 20123094]  [MGI Ref ID J:160263]

Nosavanh L; Yu DH; Jaehnig EJ; Tong Q; Shen L; Chen MH. 2015. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A 112(16):5069-74. [PubMed: 25848030]  [MGI Ref ID J:220963]

Ocbina PJ; Eggenschwiler JT; Moskowitz I; Anderson KV. 2011. Complex interactions between genes controlling trafficking in primary cilia. Nat Genet 43(6):547-53. [PubMed: 21552265]  [MGI Ref ID J:188764]

Oh S; Huang X; Liu J; Litingtung Y; Chiang C. 2009. Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Dev Biol 331(2):261-9. [PubMed: 19433083]  [MGI Ref ID J:150755]

Ohba S; Kawaguchi H; Kugimiya F; Ogasawara T; Kawamura N; Saito T; Ikeda T; Fujii K; Miyajima T; Kuramochi A; Miyashita T; Oda H; Nakamura K; Takato T; Chung UI. 2008. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14(5):689-99. [PubMed: 18477452]  [MGI Ref ID J:135169]

Oliver TG; Read TA; Kessler JD; Mehmeti A; Wells JF; Huynh TT; Lin SM; Wechsler-Reya RJ. 2005. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development 132(10):2425-39. [PubMed: 15843415]  [MGI Ref ID J:98381]

Omenetti A; Porrello A; Jung Y; Yang L; Popov Y; Choi SS; Witek RP; Alpini G; Venter J; Vandongen HM; Syn WK; Baroni GS; Benedetti A; Schuppan D; Diehl AM. 2008. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 118(10):3331-42. [PubMed: 18802480]  [MGI Ref ID J:142730]

Oro AE; Higgins K. 2003. Hair cycle regulation of Hedgehog signal reception. Dev Biol 255(2):238-48. [PubMed: 12648487]  [MGI Ref ID J:82653]

Pacheco M; Valencia M; Caparros-Martin JA; Mulero F; Goodship JA; Ruiz-Perez VL. 2012. Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base. Bone 50(1):28-41. [PubMed: 21911092]  [MGI Ref ID J:179841]

Park KS; Martelotto LG; Peifer M; Sos ML; Karnezis AN; Mahjoub MR; Bernard K; Conklin JF; Szczepny A; Yuan J; Guo R; Ospina B; Falzon J; Bennett S; Brown TJ; Markovic A; Devereux WL; Ocasio CA; Chen JK; Stearns T; Thomas RK; Dorsch M; Buonamici S; Watkins DN; Peacock CD; Sage J. 2011. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med 17(11):1504-8. [PubMed: 21983857]  [MGI Ref ID J:178123]

Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. [PubMed: 18591670]  [MGI Ref ID J:137825]

Pierucci-Alves F; Clark AM; Russell LD. 2001. A developmental study of the Desert hedgehog-null mouse testis. Biol Reprod 65(5):1392-402. [PubMed: 11673255]  [MGI Ref ID J:108687]

Pogoriler J; Millen K; Utset M; Du W. 2006. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development 133(19):3929-37. [PubMed: 16943274]  [MGI Ref ID J:115956]

Radzikinas K; Aven L; Jiang Z; Tran T; Paez-Cortez J; Boppidi K; Lu J; Fine A; Ai X. 2011. A Shh/miR-206/BDNF Cascade Coordinates Innervation and Formation of Airway Smooth Muscle. J Neurosci 31(43):15407-15. [PubMed: 22031887]  [MGI Ref ID J:177268]

Rawlins EL; Hogan BL. 2005. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 233(4):1378-85. [PubMed: 15973734]  [MGI Ref ID J:119848]

Read TA; Fogarty MP; Markant SL; McLendon RE; Wei Z; Ellison DW; Febbo PG; Wechsler-Reya RJ. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15(2):135-47. [PubMed: 19185848]  [MGI Ref ID J:144811]

Reiter JF; Skarnes WC. 2006. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev 20(1):22-7. [PubMed: 16357211]  [MGI Ref ID J:103820]

Renault MA; Chapouly C; Yao Q; Larrieu-Lahargue F; Vandierdonck S; Reynaud A; Petit M; Jaspard-Vinassa B; Belloc I; Traiffort E; Ruat M; Duplaa C; Couffinhal T; Desgranges C; Gadeau AP. 2013. Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circ Res 112(5):762-70. [PubMed: 23343527]  [MGI Ref ID J:213333]

Riccomagno MM; Martinu L; Mulheisen M; Wu DK; Epstein DJ. 2002. Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev 16(18):2365-78. [PubMed: 12231626]  [MGI Ref ID J:79100]

Riccomagno MM; Takada S; Epstein DJ. 2005. Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev 19(13):1612-23. [PubMed: 15961523]  [MGI Ref ID J:99408]

Rohatgi R; Milenkovic L; Scott MP. 2007. Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836):372-6. [PubMed: 17641202]  [MGI Ref ID J:123161]

Romer JT; Kimura H; Magdaleno S; Sasai K; Fuller C; Baines H; Connelly M; Stewart CF; Gould S; Rubin LL; Curran T. 2004. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 6(3):229-40. [PubMed: 15380514]  [MGI Ref ID J:93535]

Roper RJ; Baxter LL; Saran NG; Klinedinst DK; Beachy PA; Reeves RH. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc Natl Acad Sci U S A 103(5):1452-6. [PubMed: 16432181]  [MGI Ref ID J:105996]

Saarikangas J; Mattila PK; Varjosalo M; Bovellan M; Hakanen J; Calzada-Wack J; Tost M; Jennen L; Rathkolb B; Hans W; Horsch M; Hyvonen ME; Perala N; Fuchs H; Gailus-Durner V; Esposito I; Wolf E; de Angelis MH; Frilander MJ; Savilahti H; Sariola H; SainioK; Lehtonen S; Taipale J; Salminen M; Lappalainen P. 2011. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci 124(Pt 8):1245-55. [PubMed: 21406566]  [MGI Ref ID J:182970]

Schneider FT; Schanzer A; Czupalla CJ; Thom S; Engels K; Schmidt MH; Plate KH; Liebner S. 2010. Sonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium. Am J Pathol 177(1):404-14. [PubMed: 20508033]  [MGI Ref ID J:162106]

Seidel K; Ahn CP; Lyons D; Nee A; Ting K; Brownell I; Cao T; Carano RA; Curran T; Schober M; Fuchs E; Joyner A; Martin GR; de Sauvage FJ; Klein OD. 2010. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 137(22):3753-61. [PubMed: 20978073]  [MGI Ref ID J:167067]

Sekiguchi H; Ii M; Jujo K; Renault MA; Thorne T; Clarke T; Ito A; Tanaka T; Klyachko E; Tabata Y; Hagiwara N; Losordo D. 2012. Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein. Lab Invest 92(4):532-42. [PubMed: 22330336]  [MGI Ref ID J:181988]

Sengupta R; Dubuc A; Ward S; Yang L; Northcott P; Woerner BM; Kroll K; Luo J; Taylor MD; Wechsler-Reya RJ; Rubin JB. 2012. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res 72(1):122-32. [PubMed: 22052462]  [MGI Ref ID J:181045]

Shibukawa Y; Young B; Wu C; Yamada S; Long F; Pacifici M; Koyama E. 2007. Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236(2):426-34. [PubMed: 17191253]  [MGI Ref ID J:117221]

Shikata Y; Okada T; Hashimoto M; Ellis T; Matsumaru D; Shiroishi T; Ogawa M; Wainwright B; Motoyama J. 2011. Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Dev Biol 349(2):147-59. [PubMed: 20969845]  [MGI Ref ID J:168035]

Sicklick JK; Li YX; Melhem A; Schmelzer E; Zdanowicz M; Huang J; Caballero M; Fair JH; Ludlow JW; McClelland RE; Reid LM; Diehl AM. 2006. Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol 290(5):G859-70. [PubMed: 16322088]  [MGI Ref ID J:111078]

Singh N; Dutka T; Devenney BM; Kawasaki K; Reeves RH; Richtsmeier JT. 2015. Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology. Dis Model Mech 8(3):271-9. [PubMed: 25540129]  [MGI Ref ID J:219589]

Stottmann RW; Tran PV; Turbe-Doan A; Beier DR. 2009. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol 335(1):166-78. [PubMed: 19732765]  [MGI Ref ID J:154376]

Stottmann RW; Turbe-Doan A; Tran P; Kratz LE; Moran JL; Kelley RI; Beier DR. 2011. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS Genet 7(9):e1002224. [PubMed: 21912524]  [MGI Ref ID J:177287]

Su CY; Bay SN; Mariani LE; Hillman MJ; Caspary T. 2012. Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development 139(21):4062-71. [PubMed: 23014696]  [MGI Ref ID J:188997]

Svard J; Henricson KH; Persson-Lek M; Rozell B; Lauth M; Bergstrom A; Ericson J; Toftgard R; Teglund S. 2006. Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell 10(2):187-97. [PubMed: 16459298]  [MGI Ref ID J:105832]

Tang JY; Xiao TZ; Oda Y; Chang KS; Shpall E; Wu A; So PL; Hebert J; Bikle D; Epstein EH Jr. 2011. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila) 4(5):744-51. [PubMed: 21436386]  [MGI Ref ID J:194585]

Tang X; Kim AL; Feith DJ; Pegg AE; Russo J; Zhang H; Aszterbaum M; Kopelovich L; Epstein EH Jr; Bickers DR; Athar M. 2004. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest 113(6):867-75. [PubMed: 15067319]  [MGI Ref ID J:89218]

Tenzen T; Allen BL; Cole F; Kang JS; Krauss RS; McMahon AP. 2006. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10(5):647-56. [PubMed: 16647304]  [MGI Ref ID J:108747]

Tian H; Tenzen T; McMahon AP. 2004. Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 131(16):4021-33. [PubMed: 15269168]  [MGI Ref ID J:92058]

Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. [PubMed: 16968775]  [MGI Ref ID J:113717]

Uziel T; Karginov FV; Xie S; Parker JS; Wang YD; Gajjar A; He L; Ellison D; Gilbertson RJ; Hannon G; Roussel MF. 2009. The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci U S A 106(8):2812-7. [PubMed: 19196975]  [MGI Ref ID J:146492]

Uziel T; Zindy F; Xie S; Lee Y; Forget A; Magdaleno S; Rehg JE; Calabrese C; Solecki D; Eberhart CG; Sherr SE; Plimmer S; Clifford SC; Hatten ME; McKinnon PJ; Gilbertson RJ; Curran T; Sherr CJ; Roussel MF. 2005. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19(22):2656-67. [PubMed: 16260494]  [MGI Ref ID J:102702]

Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB. 2014. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26(1):33-47. [PubMed: 24954133]  [MGI Ref ID J:213713]

Vogt A; Hebert J; Hwang J; Lu Y; Epstein EH. 2005. Anti-rejection drug treatment increases Basal cell carcinoma burden in ptch1+/- mice. J Invest Dermatol 124(1):263-7. [PubMed: 15654983]  [MGI Ref ID J:95379]

Wakabayashi Y; Mao JH; Brown K; Girardi M; Balmain A. 2007. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature 445(7129):761-5. [PubMed: 17230190]  [MGI Ref ID J:118622]

Wall DS; Mears AJ; McNeill B; Mazerolle C; Thurig S; Wang Y; Kageyama R; Wallace VA. 2009. Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184(1):101-12. [PubMed: 19124651]  [MGI Ref ID J:146198]

Walton KD; Kolterud A; Czerwinski MJ; Bell MJ; Prakash A; Kushwaha J; Grosse AS; Schnell S; Gumucio DL. 2012. Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi. Proc Natl Acad Sci U S A 109(39):15817-22. [PubMed: 23019366]  [MGI Ref ID J:190319]

Wang Q; Huang C; Zeng F; Xue M; Zhang X. 2010. Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol 177(6):3100-11. [PubMed: 20971735]  [MGI Ref ID J:167645]

Wang YP; Dakubo G; Howley P; Campsall KD; Mazarolle CJ; Shiga SA; Lewis PM; McMahon AP; Wallace VA. 2002. Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci 5(9):831-2. [PubMed: 12195432]  [MGI Ref ID J:78708]

Wanshura LE; Galvin KE; Ye H; Fernandez-Zapico ME; Wetmore C. 2011. Sequential activation of snail1 and N-myc modulates sonic hedgehog-induced transformation of neural cells. Cancer Res 71(15):5336-45. [PubMed: 21646478]  [MGI Ref ID J:174223]

Weiss WA; Israel M; Cobbs C; Holland E; James CD; Louis DN; Marks C; McClatchey AI; Roberts T; Van Dyke T; Wetmore C; Chiu IM; Giovannini M; Guha A; Higgins RJ; Marino S; Radovanovic I; Reilly K; Aldape K. 2002. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21(49):7453-63. [PubMed: 12386807]  [MGI Ref ID J:79667]

Wetmore C; Eberhart DE; Curran T. 2001. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-6. [PubMed: 11212243]  [MGI Ref ID J:67452]

Wetmore C; Eberhart DE; Curran T. 2000. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched Cancer Res 60(8):2239-46. [PubMed: 10786690]  [MGI Ref ID J:61727]

Wong SY; Reiter JF. 2011. From the Cover: Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A 108(10):4093-8. [PubMed: 21321207]  [MGI Ref ID J:170482]

Woo WM; Zhen HH; Oro AE. 2012. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev 26(11):1235-46. [PubMed: 22661232]  [MGI Ref ID J:184827]

Wu X; Northcott PA; Dubuc A; Dupuy AJ; Shih DJ; Witt H; Croul S; Bouffet E; Fults DW; Eberhart CG; Garzia L; Van Meter T; Zagzag D; Jabado N; Schwartzentruber J; Majewski J; Scheetz TE; Pfister SM; Korshunov A; Li XN; Scherer SW; Cho YJ; Akagi K; MacDonald TJ; Koster J; McCabe MG; Sarver AL; Collins VP; Weiss WA; Largaespada DA; Collier LS; Taylor MD. 2012. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482(7386):529-33. [PubMed: 22343890]  [MGI Ref ID J:181542]

Xu J; Qi X; Gong J; Yu M; Zhang F; Sha H; Gao X. 2012. Fstl1 antagonizes BMP signaling and regulates ureter development. PLoS One 7(4):e32554. [PubMed: 22485132]  [MGI Ref ID J:187117]

Xu J; Weng Z; Arumugam A; Tang X; Chaudhary SC; Li C; Christiano AM; Elmets CA; Bickers DR; Athar M. 2014. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch(+/-) Mice. Am J Pathol 184(5):1529-40. [PubMed: 24631180]  [MGI Ref ID J:208129]

Yun JS; Rust JM; Ishimaru T; Diaz E. 2007. A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation. Mol Cell Biol 27(23):8178-89. [PubMed: 17893326]  [MGI Ref ID J:129050]

Zeng H; Hoover AN; Liu A. 2010. PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Dev Biol 339(2):418-28. [PubMed: 20067783]  [MGI Ref ID J:159120]

Zhang W; Kang JS; Cole F; Yi MJ; Krauss RS. 2006. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell 10(5):657-65. [PubMed: 16647303]  [MGI Ref ID J:108746]

Zhang XM; Ramalho-Santos M; McMahon AP. 2001. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106(2):781-92. [PubMed: 11517919]  [MGI Ref ID J:175111]

Zhao H; Ayrault O; Zindy F; Kim JH; Roussel MF. 2008. Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22(6):722-727. [PubMed: 18347090]  [MGI Ref ID J:132983]

Zhulyn O; Hui CC. 2015. Sufu and Kif7 in limb patterning and development. Dev Dyn 244(3):468-78. [PubMed: 25581370]  [MGI Ref ID J:219584]

Zindy F; Kawauchi D; Lee Y; Ayrault O; Ben Merzoug L; McKinnon PJ; Ventura A; Roussel MF. 2014. Role of the miR-17 approximately 92 cluster family in cerebellar and medulloblastoma development. Biol Open 3(7):597-605. [PubMed: 24928431]  [MGI Ref ID J:214730]

Zindy F; Uziel T; Ayrault O; Calabrese C; Valentine M; Rehg JE; Gilbertson RJ; Sherr CJ; Roussel MF. 2007. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67(6):2676-84. [PubMed: 17363588]  [MGI Ref ID J:120317]

Zurawel RH; Allen C; Wechsler-Reya R; Scott MP; Raffel C. 2000. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer 28(1):77-81. [PubMed: 10738305]  [MGI Ref ID J:61188]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, heterozygous mice are bred with wildtype mice from the colony. Homozygotes die in utero. Expected coat color from breeding is Black,Gray.
Mating System+/+ sibling x Heterozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHeterozygous for Ptch1tm1Mps  
Price per Pair (US dollars $)Pair Genotype
$313.00Heterozygous for Ptch1tm1Mps x Wild-type for Ptch1tm1Mps  
$313.00Wild-type for Ptch1tm1Mps x Heterozygous for Ptch1tm1Mps  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHeterozygous for Ptch1tm1Mps  
Price per Pair (US dollars $)Pair Genotype
$406.90Heterozygous for Ptch1tm1Mps x Wild-type for Ptch1tm1Mps  
$406.90Wild-type for Ptch1tm1Mps x Heterozygous for Ptch1tm1Mps  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   Wild-type from the colony
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is segregating the coat color allele dilute (Myo5ad). Mice can be either black or dilute grey.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.