Strain Name:

STOCK dwgBayer/J

Stock Number:

003100

Availability:

Repository- Live

Description

Strain Information

Type Mutant Stock;
Specieslaboratory mouse
GenerationN1+F28 (07-DEC-07)

Appearance
agouti
Related Genotype: A/A

Description
The dwarf-Bayer mutation (dwgBayer) occurred spontaneously in an embryonic stem cell line during genetic targeting of the insulin receptor gene. The phenotype of the mice resemble drawf grey (dwg, Stock No. 001743) and subsequent characterization determined that the two mutations are allelic. Homozygous mutant mice are grey and smaller in size than wildtype littermates.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of dwg
001743   STOCK dwg/J
View Strains carrying other alleles of dwg     (1 strain)

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

dwgBayer/dwgBayer

        STOCK dwgBayer
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:97928)
    • die by 4 weeks of age
  • growth/size phenotype
  • cachexia (MGI Ref ID J:97928)
    • wasting by 3 weeks of age
  • postnatal growth retardation (MGI Ref ID J:97928)
    • reduced growth noticed at two weeks of age
  • pigmentation phenotype
  • abnormal coat color (MGI Ref ID J:97928)
    • grey coat color noticeable at two weeks of age
  • skin/coat/nails phenotype
  • abnormal coat color (MGI Ref ID J:97928)
    • grey coat color noticeable at two weeks of age
  • vision/eye phenotype
  • cataracts (MGI Ref ID J:97928)
    • bilateral cataracts apparent

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

dwgBayer/dwgBayer

        129S/SvEv-dwgBayer
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:97928)
    • reduced growth noticed at two weeks of age
  • pigmentation phenotype
  • abnormal coat color (MGI Ref ID J:97928)
    • grey coat color noticeable at two weeks of age
  • skin/coat/nails phenotype
  • abnormal coat color (MGI Ref ID J:97928)
    • grey coat color noticeable at two weeks of age

Research Applications

This mouse can be used to support research in many areas including:

dwgBayer related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Growth Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Spleen Defects
Thyroid Defects

Internal/Organ Research
Thyroid Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol dwgBayer
Allele Name dwarf grey Bayer
Strain of Origin129S/SvEv
Gene Symbol and Name dwg, dwarf grey
Chromosome 10
Molecular Note This mutation arose spontaneously in an ES cell line during a targeted mutagenesis experiment for an unrelated gene (insulin receptor). A noncomplemetation test determined that this mutation is an allele of the original dwg mutation.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

dwgBayer related

Davis AC. 2005. Dwarf Grey Bayer, A remutation of the dwg locus MGI Direct Data Submission :.  [MGI Ref ID J:97928]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $127.90Female or MaleHeterozygous for dwgBayertested
Pairs /Price*Pair Genotype
$255.80Heterozygous for dwgBayer x Heterozygous for dwgBayertested
$149.00Heterozygous or Wild-type for dwgBayer - +/? x Heterozygous or Wild-type for dwgBayer - +/?untested
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $166.30Female or MaleHeterozygous for dwgBayertested
Pairs /Price*Pair Genotype
$332.60Heterozygous for dwgBayer x Heterozygous for dwgBayertested
$193.70Heterozygous or Wild-type for dwgBayer - +/? x Heterozygous or Wild-type for dwgBayer - +/?untested
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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