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Type Mutant Stock; Species laboratory mouse Generation N1+F28 (07-DEC-07) Appearance
agouti
Related Genotype: A/ADescription
The dwarf-Bayer mutation (dwgBayer) occurred spontaneously in an embryonic stem cell line during genetic targeting of the insulin receptor gene. The phenotype of the mice resemble drawf grey (dwg, Stock No. 001743) and subsequent characterization determined that the two mutations are allelic. Homozygous mutant mice are grey and smaller in size than wildtype littermates.
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Strains carrying other alleles of dwg
001743 STOCK dwg/J View Strains carrying other alleles of dwg (1 strain)
Mammalian Phenotype Terms assigned by genotype
dwgBayer/dwgBayer
STOCK dwgBayer
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:97928)
- die by 4 weeks of age
- growth/size phenotype
- cachexia (MGI Ref ID J:97928)
- wasting by 3 weeks of age
- postnatal growth retardation (MGI Ref ID J:97928)
- reduced growth noticed at two weeks of age
- pigmentation phenotype
- abnormal coat color (MGI Ref ID J:97928)
- grey coat color noticeable at two weeks of age
- skin/coat/nails phenotype
- abnormal coat color (MGI Ref ID J:97928)
- grey coat color noticeable at two weeks of age
- vision/eye phenotype
- cataracts (MGI Ref ID J:97928)
- bilateral cataracts apparent
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
dwgBayer/dwgBayer
129S/SvEv-dwgBayer
- growth/size phenotype
- postnatal growth retardation (MGI Ref ID J:97928)
- reduced growth noticed at two weeks of age
- pigmentation phenotype
- abnormal coat color (MGI Ref ID J:97928)
- grey coat color noticeable at two weeks of age
- skin/coat/nails phenotype
- abnormal coat color (MGI Ref ID J:97928)
- grey coat color noticeable at two weeks of age
Research Applications
This mouse can be used to support research in many areas including:dwgBayer related
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Growth Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Spleen Defects
Thyroid Defects
Internal/Organ Research
Thyroid Defects
| Allele Symbol | dwgBayer | ||
|---|---|---|---|
| Allele Name | dwarf grey Bayer | ||
| Strain of Origin | 129S/SvEv | ||
| Gene Symbol and Name | dwg, dwarf grey | ||
| Chromosome | 10 | ||
| Molecular Note | This mutation arose spontaneously in an ES cell line during a targeted mutagenesis experiment for an unrelated gene (insulin receptor). A noncomplemetation test determined that this mutation is an allele of the original dwg mutation. | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
dwgBayer related
Davis AC. 2005. Dwarf Grey Bayer, A remutation of the dwg locus MGI Direct Data Submission :. [MGI Ref ID J:97928]
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $127.90 Female or Male Heterozygous for dwgBayer tested *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $255.80 Heterozygous for dwgBayer x Heterozygous for dwgBayer tested $149.00 Heterozygous or Wild-type for dwgBayer - +/? x Heterozygous or Wild-type for dwgBayer - +/? untested
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Heterozygous for dwgBayer tested *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $332.60 Heterozygous for dwgBayer x Heterozygous for dwgBayer tested $193.70 Heterozygous or Wild-type for dwgBayer - +/? x Heterozygous or Wild-type for dwgBayer - +/? untested
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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