Description

Strain Information

Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Heterozygote x Heterozygote         (Female x Male)   25-SEP-09 Species laboratory mouse Generation N1F30N1F2 (05-NOV-09)

Appearance
agouti
Related Genotype: A/A

Description
The dwarf-Bayer mutation (dwg^Bayer) occurred spontaneously in an embryonic stem cell line during genetic targeting of the insulin receptor gene. The phenotype of the mice resemble drawf grey (dwg, Stock No. 001743) and subsequent characterization determined that the two mutations are allelic. Homozygous mutant mice are grey and smaller in size than wildtype littermates.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of dwg

001743

STOCK dwg/J

View Strains carrying other alleles of dwg     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

dwg^Bayer/dwg^Bayer

        STOCK dwg^Bayer

• lethality-postnatal
• postnatal lethality (MGI Ref ID J:97928)
  • die by 4 weeks of age
• growth/size phenotype
• cachexia (MGI Ref ID J:97928)
  • wasting by 3 weeks of age
• postnatal growth retardation (MGI Ref ID J:97928)
  • reduced growth noticed at two weeks of age
• pigmentation phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:97928)
  • grey coat color noticeable at two weeks of age
• skin/coat/nails phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:97928)
  • grey coat color noticeable at two weeks of age
• vision/eye phenotype
• cataracts (MGI Ref ID J:97928)
  • bilateral cataracts apparent

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

dwg^Bayer/dwg^Bayer

        129S/SvEv-dwg^Bayer

• growth/size phenotype
• postnatal growth retardation (MGI Ref ID J:97928)
  • reduced growth noticed at two weeks of age
• pigmentation phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:97928)
  • grey coat color noticeable at two weeks of age
• skin/coat/nails phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:97928)
  • grey coat color noticeable at two weeks of age

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

dwg^Bayer related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Growth Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Spleen Defects
Thyroid Defects

Internal/Organ Research
Thyroid Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		dwgBayer
Allele Name		dwarf grey Bayer
Allele Type		Spontaneous
Strain of Origin		129S/SvEv
Gene Symbol and Name		dwg, dwarf grey
Chromosome		10
Molecular Note		This mutation arose spontaneously in an ES cell line during a targeted mutagenesis experiment for an unrelated gene (insulin receptor). A noncomplemetation test determined that this mutation is an allele of the original dwg mutation.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

dwg^Bayer related

Davis AC. 2005. Dwarf Grey Bayer, A remutation of the dwg locus MGI Direct Data Submission :.  [MGI Ref ID J:97928]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Heterozygote x Heterozygote         (Female x Male)   25-SEP-09

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

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