JAX Mice Database - 003118 STOCK Ces1c<e> Foxn1<nu>/J

Strain Name:	STOCK Ces1c^e Foxn1^nu/J
Stock Number:	003118
Availability:	Cryopreserved - Ready for recovery

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Es1^e Foxn1^nu/J (Changed: 03-NOV-10 )

Hfh11^nu (Changed: 15-DEC-04 )

Type Mutant Stock; Spontaneous Mutation;

Additional information on Genetically Engineered and Mutant Mice.

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Species laboratory mouse

Generation ?+F1p (09-NOV-05)
Generation Definitions

Description
Mice homozygous for Ces1c^e are viable and fertile and exhibit no apparent defect.
Ces1c^e was discovered in a screen of progeny of triethylenemelamine (TEM) treated male mice for mutations at specific loci, but appears to have pre-existed in the male. The screen employed analysis of blood and kidney homogenates by "standard starch gel electrophoresis techniques" and focused on enzymes known to differ in electrophoretic mobility between the parental strains (DBA/2J and C57BL/6J). Ces1c^e was initially thought to be a null allele, but characterization of homozygous F2 mice demonstrated presence of a faint band migrating between those of the parental strains, which was not perceived in the presence of either parental band. Thus, Ces1c^e was shown to be a hypomorphic electrophoretic variant (Soares 1979).
The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1^nu, formerly Hfh11^nu) are abnormal hair growth and defective development of the thymic epithelium. Although the mice appear hairless, they are born with functional but faulty hair growth follicles. Hair growth cycles and patterns are evident especially in pigmented mice but the faulty follicles do not allow the hair to properly erupt. Homozygous pups can be identified as young as 24 hours by their lack of whiskers or poorly developed crinkled whiskers. Nude mice are also athymic caused by a developmental failure of the thymic anlage. Consequently, homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. However there is not a defect in T-cell precursors and under the right conditions some functional mature T cells can be found especially in adult mice. Because of a defect in helper T-cell activity, responses to thymus-dependent antigens when detectable are primarily limited to IgM. Homozygous nude mice show partial defect in B cell development probably due to absence of functional T cells. Other endocrine and neurological deficiences have been reported. The use of nude mice has reduced the number of thymectomy procedures required in research projects. Females are not effective breeders. Ovulation starts late at 2.5 months and ends early at 4 months.
Development
Ces1c^e was discovered in a specific-locus mutation screen of progeny of triethylenemelamine (TEM) mutagenized male DBA/2J mice, but appears to have been a pre-existing, spontaneous mutation. Although the TEM-treated parent was unavailable for genotyping, three lines of evidence suggest he was a heterozygous carrier of the mutation: 7 of 13 (54%) of his immediate offspring were heterozygous for Ces1c^e; he was mated within 2 weeks after TEM treatment, so these progeny were generated from sperm that were either sperm or late spermatids when exposed, ruling out a clustering effect due to mutagenesis at the spermatogonial stage; and the seven Ces1c^e/+ offspring occurred among litters of three dams (Soares 1979).
Mice of a strain/stock bearing Ces1c^e, called ES-IE, were imported from Dr. Soares, then at NIEH, by Dr. Eva Eicher. The original stock was maintained by sister-brother inbreeding. In 1982, Ces1c^e/Ces1c^e males of this stock were bred to C57BL/6J females to produce embryos for cryopreservation. These heterozygous embryos were assigned Stock No. 000785. In 1995, mice were recovered from the cryopreserved embryos to generate an F2 generation, from which mice homozygous for both Ces1c^e and a (nonagouti) were selected and bred to generate embryos for cryopreservation. These embryos, which are segregating for Tyrp1^b and Myo5a^d, were designated STOCK a/a Ces1c^e/Ces1c^e and retained Stock No. 000785.
STOCK Ces1c^e/Ces1c^e Foxn1^nu/+ (Stock No. 003118) was generated by mating a STOCK a/a Ces1c^e/Ces1c^e (Stock No. 00785) female to a C57BL/6J-Foxn1^nu/Foxn1^nu male, then selecting Ces1c^e homozygotes from the F2 as colony founders. Embryos were generated for cryopreservation by crossing Foxn1^nu/+ or Foxn1^nu/Foxn1^nu females to Foxn1^nu/+ or Foxn1^nu/Foxn1^nu males at generation F4+.

Related Strains

Strains carrying Foxn1^nu allele

000819 B6.Cg-Foxn1^nu/J

000711 CByJ.Cg-Foxn1^nu/J

007850 J:NU

002019 NU/J

View Strains carrying Foxn1^nu (4 strains)

Strains carrying other alleles of Ces1c

001604 B6.Cg-Ces1c^b Ces1e^h Gusb^h/J

001601 B6.YBR-Ces1c^b Ces1e^h/CvJ

000785 B6;D2-a Ces1c^e/EiJ

014096 C57BL/6-Ces1c^tm1.1Loc/J

002503 ROP/Le-Os Ces1c^a/+ Ces1c^a/J

002974 STOCK Ces1c^e H2^d/J

View Strains carrying other alleles of Ces1c (6 strains)

Strains carrying other alleles of Foxn1

000820 AKR/J-Foxn1^nu-str/J

012941 B6.129(SJL)-Foxn1^tm1.1Dmsu/J

000521 B6.AK-Foxn1^nu-str/J

000819 B6.Cg-Foxn1^nu/J

000711 CByJ.Cg-Foxn1^nu/J

007850 J:NU

002019 NU/J

View Strains carrying other alleles of Foxn1 (7 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

T-Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy - Models with phenotypic similarity to human disease where etiologies involve orthologs.¹

¹ Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Foxn1^nu/Foxn1^nu
involves: albino stock
mortality/aging

premature death

most die within a few weeks of weaning (MGI Ref ID J:30772)

integument phenotype

hairless

mice fail to grow a first coat of hair (MGI Ref ID J:30772)

Foxn1^nu/Foxn1^nu
Background Not Specified
mortality/aging

partial postnatal lethality

some mice die within 1 week of birth (MGI Ref ID J:5043)

55% mortality within 2 weeks (MGI Ref ID J:5043)

premature death

100% mortality by 25 weeks (MGI Ref ID J:5043)

endocrine/exocrine gland phenotype

small ovary (MGI Ref ID J:5043)

growth/size phenotype

decreased body size (MGI Ref ID J:5043)

decreased body weight (MGI Ref ID J:5043)

postnatal growth retardation (MGI Ref ID J:5043)

liver/biliary system phenotype

abnormal liver morphology

liver lobes were atrophied and covered with red scars (MGI Ref ID J:5043)

variable degrees of severity, typically increasing with age at time of death (MGI Ref ID J:5043)

reproductive system phenotype

abnormal estrous cycle

many females exhibited continuous dioestrus and metaoestrus phases (MGI Ref ID J:5043)

asthenozoospermia (MGI Ref ID J:5043)

coiled sperm flagellum

many sperm had coiled tails (MGI Ref ID J:5043)

female infertility

severely reduced fertility (MGI Ref ID J:5043)

reduced male fertility (MGI Ref ID J:5043)

small ovary (MGI Ref ID J:5043)

hematopoietic system phenotype

athymia (MGI Ref ID J:5059)

decreased leukocyte cell number (MGI Ref ID J:5059)

immune system phenotype

athymia (MGI Ref ID J:5059)

decreased leukocyte cell number (MGI Ref ID J:5059)

integument phenotype

absent vibrissae

absent at birth (MGI Ref ID J:5043)

hairless

sparse hair growth around 5 weeks of age (MGI Ref ID J:5043)

in some mice, cephalo-caudal migration of an irregular band of short sparse hair (MGI Ref ID J:5043)

short vibrissae

older mice show repeated growth and loss of short and wavy vibrissae (MGI Ref ID J:5043)

thin skin

reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin (MGI Ref ID J:5043)

wavy vibrissae

older mice show repeated growth and loss of short and wavy vibrissae (MGI Ref ID J:5043)

Foxn1^nu/Foxn1^nu
B6.Cg/NTac-Foxn1^nu
immune system phenotype

decreased susceptibility to parasitic infection

mice showed no sign of lesion development for up to 12 to 14 weeks post-infection; after 20 weeks, all lesions remain small (MGI Ref ID J:64283)

Foxn1^nu/Foxn1^nu
involves: BALB/c
homeostasis/metabolism phenotype

ascites

develop within 4-8 weeks of plasma cell transplant; ascites contains many plasma cells, some of which are multinucleated and contain high levels of IgA (MGI Ref ID J:40405)

tumorigenesis

increased plasmacytoma incidence

plasma cells isolated from BALB/c/C57BL/6 mice generate plasmacytomas in pristane-treated BALB/c nude mice within 4-8 weeks (MGI Ref ID J:40405)

cellular phenotype

chromosomal instability

plasmacytomas generated are near-tetraploid and contain the t(12;15) translocation (MGI Ref ID J:40405)

Foxn1^nu/Foxn1^nu
BALB/c-Foxn1^nu
immune system phenotype

abnormal circulating cytokine level

mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice (MGI Ref ID J:50903)

decreased circulating interleukin-2 level

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

decreased circulating interleukin-6 level

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

decreased circulating tumor necrosis factor level

mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and circulating cytokine levels, including TNF, unlike similarly treated wild-type mice (MGI Ref ID J:50903)

decreased interferon-gamma secretion

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

decreased susceptibility to bacterial infection

mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice (MGI Ref ID J:50903)

homeostasis/metabolism phenotype

abnormal circulating cytokine level

mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice (MGI Ref ID J:50903)

decreased circulating interleukin-2 level

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

decreased circulating interleukin-6 level

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

decreased circulating tumor necrosis factor level

mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and circulating cytokine levels, including TNF, unlike similarly treated wild-type mice (MGI Ref ID J:50903)

decreased circulating alanine transaminase level

following exposure to Pseudomonas aerugiosa exotoxin (MGI Ref ID J:50903)

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Foxn1^nu related

Dermatology Research
Skin and Hair Texture Defects

Endocrine Deficiency Research
Adrenal Cortex Defects
Skin Defects
Thyroid Defects

Immunology and Inflammation Research
Immunodeficiency
T cell deficiency

Internal/Organ Research
Thymus Defects

Research Tools
Cancer Research
xenograft/transplant host
Immunology and Inflammation Research
T cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI


Allele Symbol		Foxn1^nu
Allele Name		nude
Allele Type		Spontaneous
Common Name(s)		Foxnl^nu; Whn^-; hairless; nu;
Strain of Origin		albino stock
Gene Symbol and Name		Foxn1, forkhead box N1
Chromosome		11
Gene Common Name(s)		D11Bhm185e; DNA segment, Chr 11, Boehm 185, expressed; FKHL20; HNF-3/forkhead homolog 11; Hfh11; RONU; Rnu; WHN; nu; nude;
General Note		Dr. N.R. Grist found a hairless mutation in mice in the Virus Laboratory, Ruchill Hospital, Glasgow, and passed it on to the Institute of Animal Genetics at Edinburgh for study. Homozygotes are hairless from birth and most die within a few weeks after weaning (J:30772). Body growth rate,viability, and fertility are severely reduced. Hair follicles are normal at birth, but keratinization, which normally occurs in the middle third of the follicle, is faulty and the hairs do not erupt (J:5043). Epidermal keratinization is also faulty (J:466). Application of exogenous keratinocyte growth factor (fibroblast growth factor 7; see Fgf7) normalizes the follicular defect in Hfh11^nu/Hfh11^nu mice (J:27782). The growth retardation and ossification defects in Hfh11^nu homozygous mice was attributed to athymia (J:12665), rather than to hairlessness per se (J:20342).The thymus is almost totally absent (J:5059) due to failure of development of the thymic anlage which arises from the ectoderm of the third pharyngeal pouch. The rudiment remains small and cystic. Another derivative of the third pharyngeal pouch, the parathyroid, is unaffected by the nude mutation (J:6363). Differentiation of the stroma of the thymus into cortical and medullary parts, as recognized by monoclonal antibodies, occurs by embryonic day 13 in wild-type mice. This differentiation does not occur in Hfh11^nu/Hfh11^nu mice (J:7898). Transplantation studies have shown that the thymic rudiment of Hfh11^nu/Hfh11^nu mice fails to attract lymphoid cells, but that lymphoid cells of these mice are quite normal in their ability to populate implanted normal thymuses (J:11959). The thymic rudiment can engender some T-cell subpopulations and produce some factors with important functions (J:30766).Heterozygotes (Hfh11^nu/+) have a thymus about 50 to 80% as large as that of +/+ congenic controls, the size of the difference depending on strain background. The two genotypes can be distinguished by this criterion (J:7330). Hfh11^nu/+ mice also show a greater susceptibility to ocular infection with Herpes simplex virus infection than do +/+ mice (J:12543).Lack of the thymus in homozygotes leads to many defects of the immune system, including depletion of lymphocytes from thymus-dependent areas of lymph nodes and spleen, a much reduced lymphocyte population composed almost entirely of B-cells, relatively normal IgM response to thymus-independent antigens, very poor response to thymus-dependent antigens including failure to reject allogeneic and xenogeneic skin and tumor grafts, and greatly increased susceptibility to infection (J:11959).B cells and bone marrow stem cells are also depressed in nude mice, partly as a secondary effect of the T-cell defect. Peripheral progenmitors of mononuclear phagocytes and granulocytes are, however, abundant, and phagocytic systems are the major defense against infection (J:30766).Viability and fertility of nude mice can be greatly increased by protecting them from infectious organisms, as under specific pathogen-free or germ-free conditions (J:30766). Nude mice are widely used as naturally thymectomized mice in investigations of the role of the thymus in immune reactions.Because of its athymia and its failure to reject xenogeneic grafts, the nude mouse has also been used as a recipient for in vivo culture and study of such grafts. As Holub (J:30766) points out, the proportion of nude mouse papers devoted to studies of the mutation, as opposed to those in which the mouse is used as an athymic culture medium, has sharply declined over time. The nude mouse is regarded as thoroughly understood, and therefore usable as a research tool. Lacunae in the knowledge of the nude mutation still do exist, however. The present revue will largely disregard the extensive literature on nude mice used as tools, and will concentrate on the biology of nude.Various endocrine disorders have been described in nude mice (J:30766). A blunting of the hypothalamus-pituitary-adrenal axis response to stress stmuli has been described that occurs at both the pituitary and adrenal levels (J:12543).The nude mouse may prove to be an interesting neurophysiological model, with reductions in various central nervous system components (J:30766). Microglial cell counts in the supraventricular corpus callosum are less in nude than in normal mice (J:20954). However, cerebellar Purkinje cell and granule cell populations due not seem to be reduced in nude animals (J:20471).Flanagan (J:5043) showed linkage of the nude mutation with Re and Pmp22 on linkage group VII. Recent studies have refined the mapping with respect to successively closer mouse genes (J:4562)(J:1905), and to microsatellite loci (J:24223). As noted above, physical and transcriptional maps have further refined the location of the mutation, making positional cloning possible (J:28409)
Molecular Note		A single base pair (G) deletion in exon 3 introduces a frameshift and a premature stop codon. The encoded protein is predicted to terminate upstream of the DNA-binding domain. [MGI Ref ID J:21194]

Gene Symbol and Name		Ces1c, carboxylesterase 1C
Chromosome		8
Gene Common Name(s)		Ces-N; Ee-1; Es-1; Es-4; Es-N; Es1; Es2; esterase 1; esterase 4; esterase related gene-N;

Genotyping

Genotyping Information

Genotyping Protocols
Foxn1^nu, Pyrosequencing
Foxn1^nu, Restriction Enzyme Digest

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Cordier AC; Haumont SM. 1980. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice. Am J Anat 157(3):227-63. [PubMed: 7405870] [MGI Ref ID J:6363]

Flanagan SP. 1966. 'Nude', a new hairless gene with pleiotropic effects in the mouse. Genet Res 8(3):295-309. [PubMed: 5980117] [MGI Ref ID J:5043]

Hirasawa T; Yamashita H; Makino S. 1998. Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. Exp Anim 47(1):63-7. [PubMed: 9498115] [MGI Ref ID J:46550]

Kaestner KH; Knochel W; Martinez DE. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 14(2):142-6. [PubMed: 10702024] [MGI Ref ID J:59917]

Kaushik A; Kelsoe G; Jaton JC. 1995. The nude mutation results in impaired primary antibody repertoire. Eur J Immunol 25(2):631-634. [PubMed: 7875225] [MGI Ref ID J:23271]

Pantelouris EM. 1968. Absence of thymus in a mouse mutant. Nature 217(126):370-1. [PubMed: 5639157] [MGI Ref ID J:5059]

Segre JA; Nemhauser JL; Taylor BA; Nadeau JH; Lander ES. 1995. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics 28(3):549-59. [PubMed: 7490093] [MGI Ref ID J:28409]

Soares ER. 1979. Identification of a new allele of Es-I segregating in an inbred strain of mice. Biochem Genet 17(7-8):577-83. [PubMed: 540008] [MGI Ref ID J:6287]
Foxn1^nu related

Aikawa T; Whipple CA; Lopez ME; Gunn J; Young A; Lander AD; Korc M. 2008. Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. J Clin Invest 118(1):89-99. [PubMed: 18064304] [MGI Ref ID J:130809]

Akiyama T; Maeda S; Yamane S; Ogino K; Kasai M; Kajiura F; Matsumoto M; Inoue J. 2005. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308(5719):248-51. [PubMed: 15705807] [MGI Ref ID J:97344]

Alferink J; Schittek B; Schonrich G; Hammerling GJ; Arnold B. 1995. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int Immunol 7(2):331-6. [PubMed: 7734426] [MGI Ref ID J:144163]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269] [MGI Ref ID J:110491]

Anderson LH; Boulanger CA; Smith GH; Carmeliet P; Watson CJ. 2011. Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland. Dev Dyn :. [PubMed: 21226063] [MGI Ref ID J:168577]

Anderson MS; Venanzi ES; Chen Z; Berzins SP; Benoist C; Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39. [PubMed: 16111640] [MGI Ref ID J:100515]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029] [MGI Ref ID J:122426]

Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832] [MGI Ref ID J:113320]

Anisimov VN; Zabezhinski MA; Rossolini G; Zaia A; Piantanelli A; Basso A; Piantanelli L. 2001. Long-live euthymic BALB/c-nu mice. II: spontaneous tumors and other pathologies. Mech Ageing Dev 122(5):477-89. [PubMed: 11292513] [MGI Ref ID J:68465]

Ashkar S; Weber GF; Panoutsakopoulou V; Sanchirico ME; Jansson M; Zawaideh S; Rittling SR; Denhardt DT; Glimcher MJ; Cantor H. 2000. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287(5454):860-4. [PubMed: 10657301] [MGI Ref ID J:60284]

Augustin M; Klopp N; Ewald K; Jockusch H. 1998. A multicopy c-Myc transgene as a nuclear label: overgrowth of Myctg50 cells in allophenic mice. Cell Biol Int 22(6):401-11. [PubMed: 10328848] [MGI Ref ID J:127669]

Bakalian A; Delhaye-Bouchaud N; Mariani J. 1995. Quantitative analysis of the Purkinje cell and the granule cell populations in the cerebellum of nude mice. J Neurogenet 9(4):207-18. [PubMed: 7760211] [MGI Ref ID J:24071]

Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest 119(5):1264-74. [PubMed: 19349693] [MGI Ref ID J:149592]

Blackburn CC; Augustine CL; Li R; Harvey RP; Malin MA; Boyd RL; Miller JF; Morahan G. 1996. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors. Proc Natl Acad Sci U S A 93(12):5742-6. [PubMed: 8650163] [MGI Ref ID J:33588]

Blackburn CC; Griffith J; Morahan G. 1995. A high-resolution map of the chromosomal region surrounding the nude gene. Genomics 26(2):308-17. [PubMed: 7601457] [MGI Ref ID J:24223]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439] [MGI Ref ID J:131997]

Blyth K; Vaillant F; Hanlon L; Mackay N; Bell M; Jenkins A; Neil JC; Cameron ER. 2006. Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Res 66(4):2195-201. [PubMed: 16489021] [MGI Ref ID J:106649]

Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. [PubMed: 9820492] [MGI Ref ID J:115026]

Borsutzky S; Kretschmer K; Becker PD; Muhlradt PF; Kirschning CJ; Weiss S; Guzman CA. 2005. The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J Immunol 174(10):6308-13. [PubMed: 15879130] [MGI Ref ID J:99047]

Brandt CR. 1992. Susceptibility of +/+, +/nu and nu/nu BALB/c mice to ocular herpes simplex virus infection. Ophthalmic Res 24(6):332-7. [PubMed: 1287512] [MGI Ref ID J:12543]

Bressenot A; Marchal S; Bezdetnaya L; Garrier J; Guillemin F; Plenat F. 2009. Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. J Histochem Cytochem 57(4):289-300. [PubMed: 19029405] [MGI Ref ID J:154156]

Briat A; Vassaux G. 2008. A new transgenic mouse line to image chemically induced p53 activation in vivo. Cancer Sci 99(4):683-8. [PubMed: 18377420] [MGI Ref ID J:140273]

Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. [PubMed: 22048767] [MGI Ref ID J:179700]

Brissette JL; Li J; Kamimura J; Lee D; Dotto GP. 1996. The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation. Genes Dev 10(17):2212-21. [PubMed: 8804315] [MGI Ref ID J:35264]

Browning JL; Allaire N; Ngam-Ek A; Notidis E; Hunt J; Perrin S; Fava RA. 2005. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity 23(5):539-50. [PubMed: 16286021] [MGI Ref ID J:113284]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572] [MGI Ref ID J:118005]

Byrd LG. 1993. Regional localization of the nu mutation on mouse chromosome 11. Immunogenetics 37(2):157-9. [PubMed: 8423056] [MGI Ref ID J:4562]

Byrom B; Barbet AF; Obwolo M; Mahan SM. 2000. CD8(+) T cell knockout mice are less susceptible to Cowdria ruminantium infection than athymic, CD4(+) T cell knockout, and normal C57BL/6 mice. Vet Parasitol 93(2):159-72. [PubMed: 11035234] [MGI Ref ID J:106232]

Byun S; Lee KW; Jung SK; Lee EJ; Hwang MK; Lim SH; Bode AM; Lee HJ; Dong Z. 2010. Luteolin Inhibits Protein Kinase C{varepsilon} and c-Src Activities and UVB-Induced Skin Cancer. Cancer Res 70(6):2415-23. [PubMed: 20215519] [MGI Ref ID J:157974]

Cai J; Lee J; Kopan R; Ma L. 2009. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol 326(2):420-30. [PubMed: 19103190] [MGI Ref ID J:145163]

Cai J; Ma L. 2011. Msx2 and Foxn1 regulate nail homeostasis. Genesis 49(6):449-59. [PubMed: 21387539] [MGI Ref ID J:173664]

Campbell MR; Nation PN; Andrew SE. 2005. A lack of DNA mismatch repair on an athymic murine background predisposes to hematologic malignancy. Cancer Res 65(7):2626-35. [PubMed: 15805259] [MGI Ref ID J:97357]

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)

Cryorecovery* $1980.00

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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

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Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

	Price (US dollars $)
Cryorecovery*	$1980.00

Pricing for International shipping destinations

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)

Cryorecovery* $2574.00

Animals Provided
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

	Price (US dollars $)
Cryorecovery*	$2574.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

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Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

000819	B6.Cg-Foxn1^nu/J
000711	CByJ.Cg-Foxn1^nu/J
007850	J:NU
002019	NU/J

001604	B6.Cg-Ces1c^b Ces1e^h Gusb^h/J
001601	B6.YBR-Ces1c^b Ces1e^h/CvJ
000785	B6;D2-a Ces1c^e/EiJ
014096	C57BL/6-Ces1c^tm1.1Loc/J
002503	ROP/Le-Os Ces1c^a/+ Ces1c^a/J
002974	STOCK Ces1c^e H2^d/J

000820	AKR/J-Foxn1^nu-str/J
012941	B6.129(SJL)-Foxn1^tm1.1Dmsu/J
000521	B6.AK-Foxn1^nu-str/J
000819	B6.Cg-Foxn1^nu/J
000711	CByJ.Cg-Foxn1^nu/J
007850	J:NU
002019	NU/J

Strain Name:

STOCK Ces1ce Foxn1nu/J

Stock Number:

003118

Availability:

Cryopreserved - Ready for recovery

Strain Information

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Foxn1nu/Foxn1nu

Foxn1nu/Foxn1nu

Foxn1nu/Foxn1nu

Foxn1nu/Foxn1nu

Foxn1nu/Foxn1nu

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Animal Health Reports

Pricing, Supply Level & Notes, Controls

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Standard Supply

Supply Notes

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Standard Supply

Supply Notes

Standard Supply

General Supply Notes

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See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

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Contact information

Contracts Administration

JAX® Mice, Products & Services Conditions of Use

No Warranty

No Liability

STOCK Ces1c^e Foxn1^nu/J

Foxn1^nu/Foxn1^nu

Foxn1^nu/Foxn1^nu

Foxn1^nu/Foxn1^nu

Foxn1^nu/Foxn1^nu

Foxn1^nu/Foxn1^nu

JAX^® Mice, Products & Services Conditions of Use