Strain Name:

B6.129P2-Prlrtm1Cnp/J

Stock Number:

003142

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129P2 via E14-1 ES cell line
 
Donating InvestigatorDr. Paul A. Kelly,   Faculte de Medecine Necker

Appearance
black
Related Genotype: a/a

Description
There is complete female sterility due to abberant estrous cycles, abnormal preimplantation development of eggs, no implantation of blastocysts, lack of pseudopregnancy. Males show slightly delayed fertility. Mammary development is markedly affected. Homozygotes have no mammary development and do not lactate. Heterozygotes are unable to lactate after the first pregnancies, but attain some degree of lactation as they age or after multiple pregnancies. Serum prolactin levels are increased 60 - 100 fold in both males and females. Maternal behavior is diminished in pimiparous and nulliparous animals. Bone remodelling is decreased in homozygote mutants.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Thyroid Carcinoma, Familial Medullary; MTC
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Multiple Fibroadenomas of the Breast; MFAB   (PRLR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Prlrtm1Cnp/Prlr+

        B6.129P2-Prlrtm1Cnp/J
  • nervous system phenotype
  • abnormal neuron proliferation
    • at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice   (MGI Ref ID J:83248)
  • cellular phenotype
  • abnormal neuron proliferation
    • at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice   (MGI Ref ID J:83248)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Prlrtm1Cnp/Prlr+

        either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
  • behavior/neurological phenotype
  • abnormal maternal nurturing
    • some mothers scattered their pups, often burying them in sawdust   (MGI Ref ID J:38093)
    • abnormal pup retrieval
      • when the mother reformed the nest, a pup was often left outside and not retrieved, whereas the others were suckled   (MGI Ref ID J:38093)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • failure of lactation attributable after first, but not subsequent, pregancies   (MGI Ref ID J:38093)
  • abnormal mammary gland development
    • impaired development after first, but not subsequent, pregnancies   (MGI Ref ID J:38093)
  • integument phenotype
  • abnormal lactation
    • failure of lactation attributable after first, but not subsequent, pregancies   (MGI Ref ID J:38093)
  • abnormal mammary gland development
    • impaired development after first, but not subsequent, pregnancies   (MGI Ref ID J:38093)

Prlrtm1Cnp/Prlr+

        involves: 129P2/OlaHsd
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • mice exhibit normal spatial learning in a Morris water maze test   (MGI Ref ID J:83247)
    • abnormal maternal behavior
      • virgin female require 4 days to develop full maternal behavior towards fostered pups compared with 1 or 2 days for wild-type mice   (MGI Ref ID J:83247)
      • abnormal pup retrieval
        • virgin females take 4 to 5 days of daily exposure sessions to fostered pups to retrieve them compared with 1 or 2 daily exposure sessions for wild-type mice   (MGI Ref ID J:83247)
  • taste/olfaction phenotype
  • *normal* taste/olfaction phenotype
    • mice exhibit normal olfaction   (MGI Ref ID J:83247)
  • integument phenotype
  • abnormal hair cycle
    • intermediate timing of molting relative to homozygotes and wild-type mice   (MGI Ref ID J:70207)

Prlrtm1Cnp/Prlr+

        involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland development
    • at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice   (MGI Ref ID J:70408)
  • integument phenotype
  • abnormal mammary gland development
    • at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice   (MGI Ref ID J:70408)

Prlrtm1Cnp/Prlrtm1Cnp

        either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
  • behavior/neurological phenotype
  • abnormal sexual interaction
    • females showed increased mating frequency   (MGI Ref ID J:38093)
  • endocrine/exocrine gland phenotype
  • decreased primary ovarian follicle number
    • reduced number of primary follicles   (MGI Ref ID J:38093)
  • reproductive system phenotype
  • abnormal oogenesis
    • immature oocytes were released from the ovary   (MGI Ref ID J:38093)
  • abnormal reproductive system physiology
    • fertilization was impaired   (MGI Ref ID J:38093)
    • defective pre-implantation embryonic development   (MGI Ref ID J:38093)
    • mating did not induce pseudopregnancy   (MGI Ref ID J:38093)
    • abnormal oviduct environment   (MGI Ref ID J:38093)
    • abnormal ovulation
      • fewer than normal eggs are ovulated   (MGI Ref ID J:38093)
    • abnormal uterine environment   (MGI Ref ID J:38093)
      • abnormal decidualization
        • the uterus was refractory to implantation, though occasional implanted blastocysts were observed   (MGI Ref ID J:38093)
        • fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts   (MGI Ref ID J:38093)
    • female infertility   (MGI Ref ID J:38093)
    • male infertility
      • on a mixed background, 3 of 15 males were infertile 3 of 15 males were infertile   (MGI Ref ID J:38093)
    • reduced male fertility
      • on a mixed background, 5 of 15 males were showed impaired fertility 5 of 15 males were showed impaired fertility   (MGI Ref ID J:38093)
  • decreased primary ovarian follicle number
    • reduced number of primary follicles   (MGI Ref ID J:38093)
  • embryogenesis phenotype
  • abnormal decidualization
    • the uterus was refractory to implantation, though occasional implanted blastocysts were observed   (MGI Ref ID J:38093)
    • fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts   (MGI Ref ID J:38093)

Prlrtm1Cnp/Prlrtm1Cnp

        involves: 129P2/OlaHsd
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • mice exhibit normal spatial learning in a Morris water maze test   (MGI Ref ID J:83247)
    • abnormal maternal behavior
      • virgin females fail to develop full maternal behavior towards fostered pups even after 6 days of exposure compared with wild-type mice that require only 1-2 days of exposure   (MGI Ref ID J:83247)
      • abnormal pup retrieval
        • virgin females take 6 days of daily exposure sessions to fostered pups to retrieve them if they retrieve them at all compared with 1 or 2 daily exposure sessions for wild-type mice   (MGI Ref ID J:83247)
  • growth/size/body phenotype
  • decreased body weight
    • female mice exhibit decreased body weight compared with wild-type mice   (MGI Ref ID J:95779)
    • however, male mice exhibit normal body weight   (MGI Ref ID J:95779)
    • slow postnatal weight gain
      • after 4 months, female mice exhibit deficient weight gain compared with wild-type mice   (MGI Ref ID J:95779)
  • skeleton phenotype
  • decreased bone mineral density
    • slightly in female mice but not male mice   (MGI Ref ID J:95779)
  • taste/olfaction phenotype
  • *normal* taste/olfaction phenotype
    • mice exhibit normal olfaction   (MGI Ref ID J:83247)
  • integument phenotype
  • abnormal coat/ hair morphology
    • mice have longer hair compared with wild-type mice   (MGI Ref ID J:70207)
    • coarse hair
      • slightly after G2   (MGI Ref ID J:70207)
  • abnormal hair cycle
    • after G2, hair replacement is advanced compared to in wild-type mice   (MGI Ref ID J:70207)
    • after G2, mice no longer exhibit sexual dimorphism in fiber eruption unlike in wild-type mice   (MGI Ref ID J:70207)

Prlrtm1Cnp/Prlrtm1Cnp

        involves: 129/Sv * 129P2/OlaHsd * C57BL/6
  • skeleton phenotype
  • abnormal bone ossification
    • bone formation is decreased 60% compared to in wild-type mice   (MGI Ref ID J:52026)
    • the distance between mineralization fronts is decreased compared to in wild-type mice   (MGI Ref ID J:52026)
    • abnormal bone mineralization
      • trabecular and cortical long bone mineral apposition rates are less than in wild-type mice   (MGI Ref ID J:52026)
      • however, mineralizing and osteoblast surfaces are normal   (MGI Ref ID J:52026)
    • delayed bone ossification
      • in the calvaria at E18.5   (MGI Ref ID J:52026)
  • decreased bone mass
    • at 4 months of age as measured by bone mineral density and bone mineral content   (MGI Ref ID J:52026)
  • homeostasis/metabolism phenotype
  • abnormal circulating calcium level   (MGI Ref ID J:52026)
  • decreased circulating estradiol level
    • in female mice   (MGI Ref ID J:52026)
  • decreased circulating progesterone level
    • in female mice   (MGI Ref ID J:52026)
  • increased circulating parathyroid hormone level   (MGI Ref ID J:52026)
  • increased circulating prolactin level

Prlrtm1Cnp/Prlrtm1Cnp

        involves: 129P2/OlaHsd * 129S2/SvPas
  • reproductive system phenotype
  • abnormal prostate gland epithelium morphology
    • prostate epithelial content is reduced compared to in wild-type mice   (MGI Ref ID J:84352)
    • however, no difference is observed in castrated mice   (MGI Ref ID J:84352)
  • abnormal prostate gland ventral lobe morphology
    • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice   (MGI Ref ID J:84352)
  • increased prostate gland weight
    • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice   (MGI Ref ID J:84352)
  • increased seminal vesicle weight
    • in mature, but not young, mice   (MGI Ref ID J:84352)
  • male infertility
    • more mice exhibit total infertility than wild-type mice   (MGI Ref ID J:84352)
  • reduced male fertility
    • latency to first litter conceived by male mice is delayed compared to for wild-type mice   (MGI Ref ID J:84352)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • mice exhibit normal IgA tear composition and strain sensitivity to conjunctivitis   (MGI Ref ID J:66544)
    • abnormal lacrimal gland morphology
      • male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density   (MGI Ref ID J:66544)
      • however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology   (MGI Ref ID J:66544)
  • endocrine/exocrine gland phenotype
  • abnormal Harderian gland morphology
    • male mice exhibit a 10% increase in acinar cell density compared with wild-type mice   (MGI Ref ID J:66544)
    • however, the Harderian gland in female mice is normal   (MGI Ref ID J:66544)
  • abnormal Harderian gland physiology
    • male and female mice exhibit a decrease in solid porphyrin accretions compared with wild-type mice   (MGI Ref ID J:66544)
  • abnormal lacrimal gland morphology
    • male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density   (MGI Ref ID J:66544)
    • however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology   (MGI Ref ID J:66544)
  • abnormal prostate gland epithelium morphology
    • prostate epithelial content is reduced compared to in wild-type mice   (MGI Ref ID J:84352)
    • however, no difference is observed in castrated mice   (MGI Ref ID J:84352)
  • abnormal prostate gland ventral lobe morphology
    • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice   (MGI Ref ID J:84352)
  • increased prostate gland weight
    • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice   (MGI Ref ID J:84352)
  • increased seminal vesicle weight
    • in mature, but not young, mice   (MGI Ref ID J:84352)

Prlrtm1Cnp/Prlrtm1Cnp

        involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
  • endocrine/exocrine gland phenotype
  • abnormal pancreatic islet morphology
    • islet density is increased in weanling males and adult male and female mice compared to in wild-type mice   (MGI Ref ID J:106829)
    • decreased pancreatic beta cell mass
      • beta cell fraction and mass are reduced in male and female mice compared to in wild-type mice   (MGI Ref ID J:106829)
    • small pancreatic islets
      • islet size in weanling males is decreased compared to in wild-type mice   (MGI Ref ID J:106829)
      • however, adult male and female mice exhibit normal islet size   (MGI Ref ID J:106829)
  • decreased insulin secretion
    • islet insulin content is reduced compared to in wild-type cells   (MGI Ref ID J:106829)
    • insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice   (MGI Ref ID J:106829)
  • growth/size/body phenotype
  • decreased body weight
    • in female, but not male mice, at 27 to 37 weeks of age   (MGI Ref ID J:67354)
    • in female and male mice at 42 to 76 weeks of age   (MGI Ref ID J:67354)
    • female mice exhibit a greater reduction in body weight than male mice   (MGI Ref ID J:67354)
    • slow postnatal weight gain
      • in male and female mice   (MGI Ref ID J:67354)
  • homeostasis/metabolism phenotype
  • decreased circulating leptin level
    • in female, but not male, mice at 7 to 9 months of age   (MGI Ref ID J:67354)
  • decreased insulin secretion
    • islet insulin content is reduced compared to in wild-type cells   (MGI Ref ID J:106829)
    • insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice   (MGI Ref ID J:106829)
  • impaired glucose tolerance
  • adipose tissue phenotype
  • decreased abdominal fat pad weight
    • in male and female mice at 8 to 9 months of age   (MGI Ref ID J:67354)

Prlrtm1Cnp/Prlrtm1Cnp

        involves: 129/Sv * 129P2/OlaHsd
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • on a predominantly 129/Sv background, male mice exhibit normal reproductive morphology and fertility   (MGI Ref ID J:85593)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • on a predominantly 129/Sv background, follicle stimulating hormone, luteinizing hormone, and testosterone plasma levels are normal   (MGI Ref ID J:85593)
    • decreased body temperature   (MGI Ref ID J:101609)
    • decreased thyroxine level
      • serum-free T4 levels are lower than in wild-type mice   (MGI Ref ID J:101609)
  • endocrine/exocrine gland phenotype
  • abnormal thyroid gland morphology
    • at 2, 4, and 5 months of age, thyroid gland weight is increased compared to in wild-type mice   (MGI Ref ID J:101609)
    • mice exhibit an increase in mucus cell-like structures in the thyroid gland compared to in wild-type mice   (MGI Ref ID J:101609)
  • tumorigenesis
  • increased thyroid carcinoma incidence
    • mice develop medullary thyroid carcinomas unlike wild-type mice   (MGI Ref ID J:101609)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Prlrtm1Cnp related

Cancer Research
Growth Factors/Receptors/Cytokines

Developmental Biology Research
Skeletal Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Mammary Gland Defects
Pancreas Defects

Neurobiology Research
Behavioral and Learning Defects

Reproductive Biology Research
Endocrine Deficiencies Affecting Gonads
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Prlrtm1Cnp
Allele Name targeted mutation 1, Paul A Kelly
Allele Type Targeted (knock-out)
Common Name(s) PRLRko; Prlr-;
Mutation Made ByDr. Paul Kelly,   Faculte de Medecine Necker
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Prlr, prolactin receptor
Chromosome 15
Gene Common Name(s) AI987712; HPRL; MFAB; Pr-1; Pr-3; Prlr-rs1; RATPRLR; expressed sequence AI987712; hPRLrI; prolactin receptor 1; prolactin receptor 3; prolactin receptor related sequence 1;
Molecular Note A neomycin cassette was inserted into exon 5, creating an in-frame stop codon. Northern, Western, and binding data all demonstrate the lack of a functional receptor in homozygous mutant animals. [MGI Ref ID J:38093]

Genotyping

Genotyping Information

Genotyping Protocols

Prlrtm1Cnp, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Ormandy CJ; Camus A; Barra J; Damotte D; Lucas B; Buteau H; Edery M; Brousse N; Babinet C; Binart N; Kelly PA. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11(2):167-78. [PubMed: 9009200]  [MGI Ref ID J:38093]

Additional References

Prlrtm1Cnp related

Adan N; Guzman-Morales J; Ledesma-Colunga MG; Perales-Canales SI; Quintanar-Stephano A; Lopez-Barrera F; Mendez I; Moreno-Carranza B; Triebel J; Binart N; Martinez de la Escalera G; Thebault S; Clapp C. 2013. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. J Clin Invest 123(9):3902-13. [PubMed: 23908112]  [MGI Ref ID J:201633]

Allan GJ; Tonner E; Barber MC; Travers MT; Shand JH; Vernon RG; Kelly PA; Binart N; Flint DJ. 2002. Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor. Endocrinology 143(11):4310-9. [PubMed: 12399427]  [MGI Ref ID J:80470]

Arnold E; Thebault S; Baeza-Cruz G; Arredondo Zamarripa D; Adan N; Quintanar-Stephano A; Condes-Lara M; Rojas-Piloni G; Binart N; Martinez de la Escalera G; Clapp C. 2014. The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. J Neurosci 34(5):1868-78. [PubMed: 24478366]  [MGI Ref ID J:206956]

Auffret J; Freemark M; Carre N; Mathieu Y; Tourrel-Cuzin C; Lombes M; Movassat J; Binart N. 2013. Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period. Am J Physiol Endocrinol Metab 305(10):E1309-18. [PubMed: 24064341]  [MGI Ref ID J:205003]

Bachelot A; Beaufaron J; Servel N; Kedzia C; Monget P; Kelly PA; Gibori G; Binart N. 2009. Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes. Am J Physiol Endocrinol Metab 297(3):E676-84. [PubMed: 19531635]  [MGI Ref ID J:152499]

Bachelot A; Carre N; Mialon O; Matelot M; Servel N; Monget P; Ahtiainen P; Huhtaniemi I; Binart N. 2013. The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. Am J Physiol Endocrinol Metab 305(7):E845-52. [PubMed: 23921141]  [MGI Ref ID J:203878]

Baran N; Kelly PA; Binart N. 2002. Characterization of a prolactin-regulated gene in reproductive tissues usingthe prolactin receptor knockout mouse model. Biol Reprod 66(4):1210-8. [PubMed: 11906943]  [MGI Ref ID J:75701]

Belugin S; Diogenes AR; Patil MJ; Ginsburg E; Henry MA; Akopian AN. 2013. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. J Biol Chem 288(48):34943-55. [PubMed: 24142695]  [MGI Ref ID J:204967]

Bigsby RM; Caperell-Grant A. 2011. The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis. Carcinogenesis 32(8):1162-6. [PubMed: 21606321]  [MGI Ref ID J:174984]

Binart N; Helloco C; Ormandy CJ; Barra J; Clement-Lacroix P; Baran N; Kelly PA. 2000. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration. Endocrinology 141(7):2691-7. [PubMed: 10875275]  [MGI Ref ID J:115329]

Binart N; Imbert-Bollore P; Baran N; Viglietta C; Kelly PA. 2003. A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice. Mol Endocrinol 17(6):1066-74. [PubMed: 12624115]  [MGI Ref ID J:83628]

Binart N; Melaine N; Pineau C; Kercret H; Touzalin AM; Imbert-Bollore P; Kelly PA; Jegou B. 2003. Male reproductive function is not affected in prolactin receptor-deficient mice. Endocrinology 144(9):3779-82. [PubMed: 12933648]  [MGI Ref ID J:85593]

Bouchard B; Ormandy CJ; Di Santo JP; Kelly PA. 1999. Immune system development and function in prolactin receptor-deficient mice. J Immunol 163(2):576-82. [PubMed: 10395643]  [MGI Ref ID J:56163]

Brisken C; Kaur S; Chavarria TE; Binart N; Sutherland RL; Weinberg RA; Kelly PA; Ormandy CJ. 1999. Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol 210(1):96-106. [PubMed: 10364430]  [MGI Ref ID J:55578]

Chen CC; Stairs DB; Boxer RB; Belka GK; Horseman ND; Alvarez JV; Chodosh LA. 2012. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes Dev 26(19):2154-68. [PubMed: 23028142]  [MGI Ref ID J:188260]

Clement-Lacroix P; Ormandy C; Lepescheux L; Ammann P; Damotte D; Goffin V; Bouchard B; Amling M; Gaillard-Kelly M; Binart N; Baron R; Kelly PA. 1999. Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice. Endocrinology 140(1):96-105. [PubMed: 9886812]  [MGI Ref ID J:52026]

Costanza M; Musio S; Abou-Hamdan M; Binart N; Pedotti R. 2013. Prolactin is not required for the development of severe chronic experimental autoimmune encephalomyelitis. J Immunol 191(5):2082-8. [PubMed: 23885109]  [MGI Ref ID J:205822]

Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice. J Endocrinol 191(2):415-25. [PubMed: 17088411]  [MGI Ref ID J:114701]

Craven AJ; Ormandy CJ; Robertson FG; Wilkins RJ; Kelly PA; Nixon AJ; Pearson AJ. 2001. Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice. Endocrinology 142(6):2533-9. [PubMed: 11356702]  [MGI Ref ID J:70207]

Devi YS; Shehu A; Stocco C; Halperin J; Le J; Seibold AM; Lahav M; Binart N; Gibori G. 2009. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150(7):3327-35. [PubMed: 19342455]  [MGI Ref ID J:151799]

Fleenor D; Oden J; Kelly PA; Mohan S; Alliouachene S; Pende M; Wentz S; Kerr J; Freemark M. 2005. Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology 146(1):103-12. [PubMed: 15388648]  [MGI Ref ID J:95779]

Flint DJ; Binart N; Boumard S; Kopchick JJ; Kelly P. 2006. Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J Endocrinol 191(1):101-11. [PubMed: 17065393]  [MGI Ref ID J:114956]

Freemark M; Avril I; Fleenor D; Driscoll P; Petro A; Opara E; Kendall W; Oden J; Bridges S; Binart N; Breant B; Kelly PA. 2002. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology 143(4):1378-85. [PubMed: 11897695]  [MGI Ref ID J:106829]

Freemark M; Fleenor D; Driscoll P; Binart N; Kelly P. 2001. Body weight and fat deposition in prolactin receptor-deficient mice. Endocrinology 142(2):532-7. [PubMed: 11159821]  [MGI Ref ID J:67354]

Gallego MI; Binart N; Robinson GW; Okagaki R; Coschigano KT; Perry J; Kopchick JJ; Oka T; Kelly PA; Hennighausen L. 2001. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 229(1):163-75. [PubMed: 11133161]  [MGI Ref ID J:66900]

Grimm SL; Seagroves TN; Kabotyanski EB; Hovey RC; Vonderhaar BK; Lydon JP; Miyoshi K; Hennighausen L; Ormandy CJ; Lee AV; Stull MA; Wood TL; Rosen JM. 2002. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol 16(12):2675-91. [PubMed: 12456789]  [MGI Ref ID J:125450]

Grosdemouge I; Bachelot A; Lucas A; Baran N; Kelly PA; Binart N. 2003. Effects of deletion of the prolactin receptor on ovarian gene expression. Reprod Biol Endocrinol 1:12. [PubMed: 12646063]  [MGI Ref ID J:102442]

Halperin J; Devi SY; Elizur S; Stocco C; Shehu A; Rebourcet D; Unterman TG; Leslie ND; Le J; Binart N; Gibori G. 2008. Prolactin Signaling through the Short Form of Its Receptor Represses Forkhead Transcription Factor FOXO3 and Its Target Gene Galt Causing a Severe Ovarian Defect. Mol Endocrinol 22(2):513-22. [PubMed: 17975019]  [MGI Ref ID J:130265]

Harris J; Stanford PM; Sutherland K; Oakes SR; Naylor MJ; Robertson FG; Blazek KD; Kazlauskas M; Hilton HN; Wittlin S; Alexander WS; Lindeman GJ; Visvader JE; Ormandy CJ. 2006. Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol 20(5):1177-87. [PubMed: 16469767]  [MGI Ref ID J:108377]

Hilton HN; Stanford PM; Harris J; Oakes SR; Kaplan W; Daly RJ; Ormandy CJ. 2008. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta 1783(3):383-93. [PubMed: 18190796]  [MGI Ref ID J:133423]

Huang C. 2013. Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive beta-cell responses during pregnancy. J Physiol 591(Pt 5):1325-38. [PubMed: 23247113]  [MGI Ref ID J:207359]

Huang C; Snider F; Cross JC. 2009. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology 150(4):1618-26. [PubMed: 19036882]  [MGI Ref ID J:158082]

Hughes E; Huang C. 2011. Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation. Endocrinology 152(3):847-55. [PubMed: 21239436]  [MGI Ref ID J:173881]

Kedzia C; Lacroix L; Ameur N; Ragot T; Kelly PA; Caillou B; Binart N. 2005. Medullary thyroid carcinoma arises in the absence of prolactin signaling. Cancer Res 65(18):8497-503. [PubMed: 16166330]  [MGI Ref ID J:101609]

Le Provost F; Miyoshi K; Vilotte JL; Bierie B; Robinson GW; Hennighausen L. 2005. SOCS3 promotes apoptosis of mammary differentiated cells. Biochem Biophys Res Commun 338(4):1696-701. [PubMed: 16289036]  [MGI Ref ID J:104012]

Lindeman GJ; Wittlin S; Lada H; Naylor MJ; Santamaria M; Zhang JG; Starr R; Hilton DJ; Alexander WS; Ormandy CJ; Visvader J. 2001. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 15(13):1631-6. [PubMed: 11445538]  [MGI Ref ID J:70408]

Long W; Wagner KU; Lloyd KC; Binart N; Shillingford JM; Hennighausen L; Jones FE. 2003. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development 130(21):5257-68. [PubMed: 12954715]  [MGI Ref ID J:86319]

Lucas BK; Ormandy CJ; Binart N; Bridges RS; Kelly PA. 1998. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology 139(10):4102-7. [PubMed: 9751488]  [MGI Ref ID J:83247]

Mak GK; Enwere EK; Gregg C; Pakarainen T; Poutanen M; Huhtaniemi I; Weiss S. 2007. Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci 10(8):1003-11. [PubMed: 17603480]  [MGI Ref ID J:124216]

Mak GK; Weiss S. 2010. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nat Neurosci 13(6):753-8. [PubMed: 20453850]  [MGI Ref ID J:161454]

McClellan KA; Robertson FG; Kindblom J; Wennbo H; Tornell J; Bouchard B; Kelly PA; Ormandy CJ. 2001. Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice Invest Ophthalmol Vis Sci 42(1):23-30. [PubMed: 11133844]  [MGI Ref ID J:66544]

Nilsson L; Binart N; Bohlooly-Y M; Bramnert M; Egecioglu E; Kindblom J; Kelly PA; Kopchick JJ; Ormandy CJ; Ling C; Billig H. 2005. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun 331(4):1120-6. [PubMed: 15882993]  [MGI Ref ID J:98282]

Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ. 2007. Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene 26(4):543-53. [PubMed: 16862169]  [MGI Ref ID J:117839]

Pasek RC; Gannon M. 2013. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab 305(11):E1327-38. [PubMed: 24085033]  [MGI Ref ID J:204991]

Patil MJ; Green DP; Henry MA; Akopian AN. 2013. Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice. Neuroscience 253:132-41. [PubMed: 23994182]  [MGI Ref ID J:207435]

Patil MJ; Ruparel SB; Henry MA; Akopian AN. 2013. Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain. Am J Physiol Endocrinol Metab 305(9):E1154-64. [PubMed: 24022869]  [MGI Ref ID J:204510]

Reese J; Binart N; Brown N; Ma WG; Paria BC; Das SK; Kelly PA; Dey SK. 2000. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology 141(5):1872-81. [PubMed: 10803598]  [MGI Ref ID J:61911]

Riedlinger G; Okagaki R; Wagner KU; Rucker EB 3rd; Oka T; Miyoshi K; Flaws JA; Hennighausen L. 2002. Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol Reprod 66(2):438-44. [PubMed: 11804960]  [MGI Ref ID J:108582]

Robertson FG; Harris J; Naylor MJ; Oakes SR; Kindblom J; Dillner K; Wennbo H; Tornell J; Kelly PA; Green J; Ormandy CJ. 2003. Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology 144(7):3196-205. [PubMed: 12810576]  [MGI Ref ID J:84352]

Schuff KG; Hentges ST; Kelly MA; Binart N; Kelly PA; Iuvone PM; Asa SL; Low MJ. 2002. Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. J Clin Invest 110(7):973-81. [PubMed: 12370275]  [MGI Ref ID J:79683]

Shingo T; Gregg C; Enwere E; Fujikawa H; Hassam R; Geary C; Cross JC; Weiss S. 2003. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299(5603):117-20. [PubMed: 12511652]  [MGI Ref ID J:83248]

Viengchareun S; Servel N; Feve B; Freemark M; Lombes M; Binart N. 2008. Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2. PLoS ONE 3(2):e1535. [PubMed: 18253483]  [MGI Ref ID J:132155]

Zhou J; Chehab R; Tkalcevic J; Naylor MJ; Harris J; Wilson TJ; Tsao S; Tellis I; Zavarsek S; Xu D; Lapinskas EJ; Visvader J; Lindeman GJ; Thomas R; Ormandy CJ; Hertzog PJ; Kola I; Pritchard MA. 2005. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J 24(3):635-44. [PubMed: 15650748]  [MGI Ref ID J:96237]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)