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Strain Name:

WLC.C-H2d.GR-Mtv2/MorJ

Stock Number:

003153

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      WLC-2/d    (Changed: 15-DEC-04 )
      WLC.C2-H2d.GR-Mtv2/Mor    (Changed: 15-DEC-04 )
      WLC.Cg-H2d.GR-Mtv2/Mor    (Changed: 15-DEC-04 )
Genes & Alleles   H2;   H2d;   Mtv2;   ;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Major Histocompatibility Congenic
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
GenerationF?+3p (19-DEC-04)

Strain Description
The GR strain carries five endogenous proviral copies of mouse mammary tumor virus (MMTV) including Mtv2. In GR, Mtv2 causes mammary carcinomas in 100% of breeding females prior to one year of age. Mtv2 deletes T cells carrying V beta 14 in the presence of MHC class II I-E (Ferrick 1992). This double congenic carries the GR Mtv2 locus in an exogenous and endogenous MMTV-free genetic background (WLC/MorJ, Stock No. 002600) and in an H2d background. This congenic represents a model for studying MMTV-induced mammary tumorigenesis in the absence of multiple endogenous proviruses (Morris 1986). Mammary tumor incidence has not been confirmed at The Jackson Laboratory.

Strain Development
WLC/MorJ (Stock #002600) was derived from inbreeding MMTV-free wild mice from Lake Casitas, CA. WLC/MorJ represents a endogenous and exogenous MMTV-free genetic background. WLC/MorJ is not permissive for MMTV expression. To permit expression, WLC/MorJ was made congenic for the BALB/c H2d locus. The Mtv2 locus has not been fully backcrossed to WLC/MorJ; it is believed to be 94% congenic (Morris, personal communication). The Jackson Laboratory received the colony in 1997.

Gene & Allele Details

Allele Symbol H2d
Allele Name d variant
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
General Note The d variant has been observed in the following strains: DBA/2, DBA/2J BALB/c, BALB/cByJ, BALB/cJ, C57BLKS, NZB
Gene Symbol and Name Mtv2, mammary tumor virus locus 2
Chromosome 18
Gene Common Name(s) Mtv-2;

Related Strains

View Strains carrying   H2d     (13 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Mammary Gland Tumors)

H2d related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

References

Additional References

Price and Supply Information

Strain Name: WLC.C-H2d.GR-Mtv2/MorJ
Stock Number: 003153

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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