Strain Name:

C.129S4-Il2rgtm1Wjl/J

Stock Number:

003169

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain 129S4 via J1 ES cell line
 
Donating InvestigatorDr. Warren J. Leonard,   NHLBI, NIH

Appearance
albino
Related Genotype: Tyrc/Tyrc Tyrp1b/Tyrp1b A/A

Description
Mice homozygous for the Il2rgtm1Wjl targeted mutation are viable and fertile. Mutant mice have hypoplastic thymuses with a 10-fold reduction in the absolute number of lymphocytes. They have a limited number of mature splenic B and T cells, lack NK cells and Peyer's patches, and development of gut-associated intraepithelial lymphocytes is diminished. In vitro studies show defects in NK activity, IL4-directed Ig class switching of thymocytes, and thymocyte mitogenic responses.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Il2rgtm1Wjl     (19 strains)

View Strains carrying other alleles of Il2rg     (9 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Combined Immunodeficiency, X-Linked; CIDX   (IL2RG)
Severe Combined Immunodeficiency, X-Linked; SCIDX1   (IL2RG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Il2rgtm1Wjl/Il2rgtm1Wjl

        B6.129S4-Il2rgtm1Wjl/J
  • immune system phenotype
  • abnormal dendritic cell physiology
    • in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis   (MGI Ref ID J:123902)
    • bone marrow-derived dendritic cells overproduce IL12 and IL10   (MGI Ref ID J:123902)
  • abnormal splenic cell ratio
    • reduced numbers of splenocytes   (MGI Ref ID J:123902)
    • decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen   (MGI Ref ID J:123902)
  • decreased myeloid dendritic cell number
    • the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen   (MGI Ref ID J:123902)
  • hematopoietic system phenotype
  • abnormal splenic cell ratio
    • reduced numbers of splenocytes   (MGI Ref ID J:123902)
    • decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen   (MGI Ref ID J:123902)
  • decreased myeloid dendritic cell number
    • the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen   (MGI Ref ID J:123902)

Il2rgtm1Wjl/Y

        involves: 129S4/SvJae * C57BL/6
  • immune system phenotype
  • abnormal cell-mediated immunity   (MGI Ref ID J:108209)
    • abnormal basophil physiology
      • IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold   (MGI Ref ID J:24117)
    • abnormal mast cell physiology
      • IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold   (MGI Ref ID J:24117)
    • abnormal thymocyte activation
      • marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation   (MGI Ref ID J:24117)
    • decreased T cell proliferation
      • less potent proliferation of splenic T cells to mitogen stimulation   (MGI Ref ID J:24117)
    • decreased immunoglobulin level
      • concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice   (MGI Ref ID J:24117)
    • impaired natural killer cell mediated cytotoxicity
      • no NK cytolytic acitivity detected   (MGI Ref ID J:24117)
  • abnormal immune serum protein physiology   (MGI Ref ID J:108209)
    • decreased immunoglobulin level
      • concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice   (MGI Ref ID J:24117)
    • decreased interferon-gamma secretion
      • IFN-gamma production by stimulated T cells is reduced by a 1000 fold   (MGI Ref ID J:24117)
    • decreased interleukin-2 secretion
      • production of IL-2 by stimulated T cells is reduced by about 40%   (MGI Ref ID J:24117)
    • decreased interleukin-4 secretion
      • production of IL-4 by stimulated T cells is reduced by about 40%   (MGI Ref ID J:24117)
  • abnormal immune system organ morphology   (MGI Ref ID J:108209)
    • abnormal gut-associated lymphoid tissue morphology
      • gut associated lymphoid tissue was absent in the small and large intestine   (MGI Ref ID J:24117)
    • abnormal mesenteric lymph node morphology
      • small, with few follicles and no germinal centers   (MGI Ref ID J:24117)
    • small lymph nodes
      • peripheral lymph nodes are not identifiable   (MGI Ref ID J:24117)
    • small thymus
      • thymus is very small   (MGI Ref ID J:24117)
    • spleen hyperplasia
      • about a 2 fold increase in cellularity at nine weeks of age   (MGI Ref ID J:24117)
    • spleen hypoplasia
      • about a 10 fold reduction in cellularity at three weeks of age   (MGI Ref ID J:24117)
    • thymus cortex hypoplasia
      • cortex is reduced in size   (MGI Ref ID J:24117)
    • thymus hyperplasia
      • after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts   (MGI Ref ID J:108209)
  • abnormal lymphocyte morphology   (MGI Ref ID J:108209)
    • abnormal B cell number
      • after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity   (MGI Ref ID J:108209)
      • decreased immature B cell number
        • absolute numbers are reduced in the spleen   (MGI Ref ID J:24117)
    • abnormal CD4-positive, alpha beta T cell morphology
      • when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells   (MGI Ref ID J:108209)
    • abnormal thymocyte activation
      • marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation   (MGI Ref ID J:24117)
    • absent NK cells
      • NK1.1 positive cells are not detected   (MGI Ref ID J:24117)
    • absent gamma-delta T cells
      • no gamma-delta T cells are found in the thymus or the skin   (MGI Ref ID J:24117)
      • absent gamma-delta intraepithelial T cell
        • no gamma-delta IEL are found in the intestine   (MGI Ref ID J:24117)
    • decreased CD8-positive, alpha-beta T cell number
      • 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen   (MGI Ref ID J:24117)
      • percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age   (MGI Ref ID J:24117)
    • decreased T cell proliferation
      • less potent proliferation of splenic T cells to mitogen stimulation   (MGI Ref ID J:24117)
    • decreased double-negative T cell number
      • there is a reduced number of double-positive T cells in the thymus   (MGI Ref ID J:24117)
    • decreased double-positive T cell number
      • there is a reduced number of double-negative T cells in the thymus   (MGI Ref ID J:24117)
    • decreased single-positive T cell number
      • there is a reduced number of single-postive T cells in the thymus   (MGI Ref ID J:24117)
  • cecum inflammation
    • cecum inflammation is visible in the lamina propia   (MGI Ref ID J:24117)
  • digestive/alimentary phenotype
  • abnormal cecum morphology
    • crypt height is increased and inflammation is visible in the lamina propia   (MGI Ref ID J:24117)
  • cecum inflammation
    • cecum inflammation is visible in the lamina propia   (MGI Ref ID J:24117)
  • hematopoietic system phenotype
  • abnormal basophil physiology
    • IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold   (MGI Ref ID J:24117)
  • abnormal lymphocyte morphology   (MGI Ref ID J:108209)
    • abnormal B cell number
      • after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity   (MGI Ref ID J:108209)
      • decreased immature B cell number
        • absolute numbers are reduced in the spleen   (MGI Ref ID J:24117)
    • abnormal CD4-positive, alpha beta T cell morphology
      • when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells   (MGI Ref ID J:108209)
    • abnormal thymocyte activation
      • marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation   (MGI Ref ID J:24117)
    • absent NK cells
      • NK1.1 positive cells are not detected   (MGI Ref ID J:24117)
    • absent gamma-delta T cells
      • no gamma-delta T cells are found in the thymus or the skin   (MGI Ref ID J:24117)
      • absent gamma-delta intraepithelial T cell
        • no gamma-delta IEL are found in the intestine   (MGI Ref ID J:24117)
    • decreased CD8-positive, alpha-beta T cell number
      • 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen   (MGI Ref ID J:24117)
      • percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age   (MGI Ref ID J:24117)
    • decreased T cell proliferation
      • less potent proliferation of splenic T cells to mitogen stimulation   (MGI Ref ID J:24117)
    • decreased double-negative T cell number
      • there is a reduced number of double-positive T cells in the thymus   (MGI Ref ID J:24117)
    • decreased double-positive T cell number
      • there is a reduced number of double-negative T cells in the thymus   (MGI Ref ID J:24117)
    • decreased single-positive T cell number
      • there is a reduced number of single-postive T cells in the thymus   (MGI Ref ID J:24117)
  • abnormal mast cell physiology
    • IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold   (MGI Ref ID J:24117)
  • decreased immunoglobulin level
    • concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice   (MGI Ref ID J:24117)
  • impaired natural killer cell mediated cytotoxicity
    • no NK cytolytic acitivity detected   (MGI Ref ID J:24117)
  • small thymus
    • thymus is very small   (MGI Ref ID J:24117)
  • spleen hyperplasia
    • about a 2 fold increase in cellularity at nine weeks of age   (MGI Ref ID J:24117)
  • spleen hypoplasia
    • about a 10 fold reduction in cellularity at three weeks of age   (MGI Ref ID J:24117)
  • thymus cortex hypoplasia
    • cortex is reduced in size   (MGI Ref ID J:24117)
  • thymus hyperplasia
    • after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts   (MGI Ref ID J:108209)
  • endocrine/exocrine gland phenotype
  • abnormal thymocyte activation
    • marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation   (MGI Ref ID J:24117)
  • small thymus
    • thymus is very small   (MGI Ref ID J:24117)
  • thymus cortex hypoplasia
    • cortex is reduced in size   (MGI Ref ID J:24117)
  • thymus hyperplasia
    • after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts   (MGI Ref ID J:108209)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Inflammation
      Inflammatory bowel disease

Research Tools
Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Il2rgtm1Wjl related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il2rgtm1Wjl
Allele Name targeted mutation 1, Warren J Leonard
Allele Type Targeted (Null/Knockout)
Common Name(s) CD132-; IL2Rgammanull; Il2rgtm1Wjll; [KO]gammac; gammac-; gc-;
Mutation Made ByDr. Warren Leonard,   NHLBI, NIH
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Il2rg, interleukin 2 receptor, gamma chain
Chromosome X
Gene Common Name(s) Ab2-183; CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gc;
Molecular Note A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. [MGI Ref ID J:24117]

Genotyping

Genotyping Information

Genotyping Protocols

Il2rgtm1Wjl-PROBE,

Probe



Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Cao X; Shores EW; Hu-Li J; Anver MR; Kelsall BL; Russell SM; Drago J; Noguchi M; Grinberg A; Bloom ET; Paul WE; Katz SI; Love PE; Leonard WJ. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2(3):223-38. [PubMed: 7697543]  [MGI Ref ID J:24117]

Additional References

Nakajima H; Leonard WJ. 1997. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice. J Immunol 159(10):4737-44. [PubMed: 9366397]  [MGI Ref ID J:43962]

Il2rgtm1Wjl related

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]  [MGI Ref ID J:142410]

Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes. PLoS One 6(6):e20169. [PubMed: 21695116]  [MGI Ref ID J:174292]

Al-Shami A; Spolski R; Kelly J; Fry T; Schwartzberg PL; Pandey A; Mackall CL; Leonard WJ. 2004. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 200(2):159-68. [PubMed: 15263024]  [MGI Ref ID J:108209]

Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. [PubMed: 22937164]  [MGI Ref ID J:191672]

Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. [PubMed: 20668220]  [MGI Ref ID J:163262]

Arpke RW; Darabi R; Mader TL; Zhang Y; Toyama A; Lonetree CL; Nash N; Lowe DA; Perlingeiro RC; Kyba M. 2013. A New Immuno- Dystrophin-Deficient Model, the NSG-Mdx Mouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation. Stem Cells :. [PubMed: 23606600]  [MGI Ref ID J:199729]

Ashkar AA; Black GP; Wei Q; He H; Liang L; Head JR; Croy BA. 2003. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171(6):2937-44. [PubMed: 12960317]  [MGI Ref ID J:85375]

Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. [PubMed: 22065769]  [MGI Ref ID J:180174]

Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. [PubMed: 23225891]  [MGI Ref ID J:190812]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. [PubMed: 21266536]  [MGI Ref ID J:172780]

Bayer AL; Lee JY; de la Barrera A; Surh CD; Malek TR. 2008. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 181(1):225-34. [PubMed: 18566388]  [MGI Ref ID J:137409]

Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. [PubMed: 24263804]  [MGI Ref ID J:206976]

Bertilaccio MT; Simonetti G; Dagklis A; Rocchi M; Rodriguez TV; Apollonio B; Mantovani A; Ponzoni M; Ghia P; Garlanda C; Caligaris-Cappio F; Muzio M. 2011. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 118(3):660-9. [PubMed: 21652674]  [MGI Ref ID J:174861]

Bezman NA; Chakraborty T; Bender T; Lanier LL. 2011. miR-150 regulates the development of NK and iNKT cells. J Exp Med 208(13):2717-31. [PubMed: 22124110]  [MGI Ref ID J:179053]

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice. Blood 117(11):3076-86. [PubMed: 21252091]  [MGI Ref ID J:170510]

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. [PubMed: 23833235]  [MGI Ref ID J:205706]

Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. [PubMed: 22890824]  [MGI Ref ID J:191833]

Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. [PubMed: 20688981]  [MGI Ref ID J:167433]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. [PubMed: 22246028]  [MGI Ref ID J:180273]

Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. [PubMed: 22048767]  [MGI Ref ID J:179700]

Bucher C; Koch L; Vogtenhuber C; Goren E; Munger M; Panoskaltsis-Mortari A; Sivakumar P; Blazar BR. 2009. IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 114(26):5375-84. [PubMed: 19843883]  [MGI Ref ID J:155701]

Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. [PubMed: 17681665]  [MGI Ref ID J:126691]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280-90. [PubMed: 17182565]  [MGI Ref ID J:141932]

Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32(4):860-73. [PubMed: 24715688]  [MGI Ref ID J:210438]

Chappaz S; Finke D. 2010. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol 184(7):3562-9. [PubMed: 20207995]  [MGI Ref ID J:160069]

Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. [PubMed: 20016601]  [MGI Ref ID J:155800]

Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. [PubMed: 24474774]  [MGI Ref ID J:206650]

Cheng G; Yu A; Dee MJ; Malek TR. 2013. IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development. J Immunol 190(4):1567-75. [PubMed: 23315074]  [MGI Ref ID J:193324]

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Hoglund P; Jacobsen SE; Sitnicka E. 2009. Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development. J Immunol 182(3):1460-8. [PubMed: 19155493]  [MGI Ref ID J:144325]

Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. [PubMed: 23965627]  [MGI Ref ID J:205431]

Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. [PubMed: 21429805]  [MGI Ref ID J:173961]

Civenni G; Walter A; Kobert N; Mihic-Probst D; Zipser M; Belloni B; Seifert B; Moch H; Dummer R; van den Broek M; Sommer L. 2011. Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth. Cancer Res 71(8):3098-109. [PubMed: 21393506]  [MGI Ref ID J:170990]

Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. [PubMed: 23378057]  [MGI Ref ID J:196312]

Constantinides MG; McDonald BD; Verhoef PA; Bendelac A. 2014. A committed precursor to innate lymphoid cells. Nature :. [PubMed: 24509713]  [MGI Ref ID J:205609]

Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. [PubMed: 16582912]  [MGI Ref ID J:112393]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Danner R; Chaudhari SN; Rosenberger J; Surls J; Richie TL; Brumeanu TD; Casares S. 2011. Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells. PLoS One 6(5):e19826. [PubMed: 21611197]  [MGI Ref ID J:172588]

Darabi R; Gehlbach K; Bachoo RM; Kamath S; Osawa M; Kamm KE; Kyba M; Perlingeiro RC. 2008. Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nat Med 14(2):134-43. [PubMed: 18204461]  [MGI Ref ID J:133565]

Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. [PubMed: 23430111]  [MGI Ref ID J:196692]

Davies E; Reid S; Medina MF; Lichty B; Ashkar AA. 2010. IL-15 has innate anti-tumor activity independent of NK and CD8 T cells. J Leukoc Biol 88(3):529-36. [PubMed: 20538758]  [MGI Ref ID J:164922]

Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. [PubMed: 23896410]  [MGI Ref ID J:202360]

Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. [PubMed: 22593616]  [MGI Ref ID J:188965]

Eidenschenk C; Crozat K; Krebs P; Arens R; Popkin D; Arnold CN; Blasius AL; Benedict CA; Moresco EM; Xia Y; Beutler B. 2010. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A :. [PubMed: 20457904]  [MGI Ref ID J:159599]

Eisenring M; vom Berg J; Kristiansen G; Saller E; Becher B. 2010. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8. [PubMed: 20935648]  [MGI Ref ID J:166535]

El Haddad N; Heathcote D; Moore R; Yang S; Azzi J; Mfarrej B; Atkinson M; Sayegh MH; Lee JS; Ashton-Rickardt PG; Abdi R. 2011. Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood 117(4):1176-83. [PubMed: 21076046]  [MGI Ref ID J:168605]

Enquist IB; Good Z; Jubb AM; Fuh G; Wang X; Junttila MR; Jackson EL; Leong KG. 2014. Lymph node-independent liver metastasis in a model of metastatic colorectal cancer. Nat Commun 5:3530. [PubMed: 24667486]  [MGI Ref ID J:210473]

Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. [PubMed: 22617213]  [MGI Ref ID J:185539]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Fiorini E; Ferrero I; Merck E; Favre S; Pierres M; Luther SA; MacDonald HR. 2008. Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. J Immunol 181(12):8199-203. [PubMed: 19050235]  [MGI Ref ID J:142081]

Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. [PubMed: 23467088]  [MGI Ref ID J:194916]

Fontenot JD; Rasmussen JP; Gavin MA; Rudensky AY. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6(11):1142-51. [PubMed: 16227984]  [MGI Ref ID J:112602]

Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. [PubMed: 20729912]  [MGI Ref ID J:166563]

Gill N; Rosenthal KL; Ashkar AA. 2005. NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J Virol 79(7):4470-8. [PubMed: 15767447]  [MGI Ref ID J:97038]

Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. [PubMed: 20671189]  [MGI Ref ID J:162606]

Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. [PubMed: 20495069]  [MGI Ref ID J:161304]

Guimond M; Leonard WJ; Spolski R; Rossi SW; Veenstra RG; Hollander GA; Mackall CL; Blazar BR. 2008. Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood 111(2):969-70. [PubMed: 18182587]  [MGI Ref ID J:130979]

Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. [PubMed: 19136960]  [MGI Ref ID J:144504]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. [PubMed: 23925295]  [MGI Ref ID J:201617]

Hao J; Shi FD; Abdelwahab M; Shi SX; Simard A; Whiteaker P; Lukas R; Zhou Q. 2013. Nicotinic receptor beta2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. PLoS One 8(2):e57495. [PubMed: 23469004]  [MGI Ref ID J:197263]

Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. [PubMed: 22464800]  [MGI Ref ID J:189339]

Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. [PubMed: 20068223]  [MGI Ref ID J:162612]

Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. [PubMed: 19324903]  [MGI Ref ID J:148898]

Holland JD; Gyorffy B; Vogel R; Eckert K; Valenti G; Fang L; Lohneis P; Elezkurtaj S; Ziebold U; Birchmeier W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep 5(5):1214-27. [PubMed: 24290754]  [MGI Ref ID J:206839]

Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. [PubMed: 22343031]  [MGI Ref ID J:184937]

Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. [PubMed: 20601939]  [MGI Ref ID J:162607]

Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. [PubMed: 21926352]  [MGI Ref ID J:178783]

Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. [PubMed: 22753496]  [MGI Ref ID J:186492]

Imtiyaz HZ; Zhou X; Zhang H; Chen D; Hu T; Zhang J. 2009. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation. J Biol Chem 284(15):9917-26. [PubMed: 19203997]  [MGI Ref ID J:149068]

Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. [PubMed: 22558161]  [MGI Ref ID J:187283]

Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. [PubMed: 15920010]  [MGI Ref ID J:142411]

Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. [PubMed: 19802382]  [MGI Ref ID J:154110]

Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. [PubMed: 20072130]  [MGI Ref ID J:162611]

Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. [PubMed: 20505160]  [MGI Ref ID J:163485]

Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. [PubMed: 18852293]  [MGI Ref ID J:141103]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Karst AM; Levanon K; Drapkin R. 2011. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A 108(18):7547-52. [PubMed: 21502498]  [MGI Ref ID J:172047]

Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. [PubMed: 22897850]  [MGI Ref ID J:191823]

Kelly J; Spolski R; Imada K; Bollenbacher J; Lee S; Leonard WJ. 2003. A role for stat5 in CD8(+) T cell homeostasis. J Immunol 170(1):210-7. [PubMed: 12496402]  [MGI Ref ID J:80897]

Kim HJ; Verbinnen B; Tang X; Lu L; Cantor H. 2010. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 467(7313):328-32. [PubMed: 20844537]  [MGI Ref ID J:164663]

Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. [PubMed: 21873530]  [MGI Ref ID J:179333]

Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. [PubMed: 23300950]  [MGI Ref ID J:195822]

King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. [PubMed: 19659776]  [MGI Ref ID J:151390]

Klose CS; Kiss EA; Schwierzeck V; Ebert K; Hoyler T; d'Hargues Y; Goppert N; Croxford AL; Waisman A; Tanriver Y; Diefenbach A. 2013. A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature 494(7436):261-5. [PubMed: 23334414]  [MGI Ref ID J:194555]

Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. [PubMed: 24209604]  [MGI Ref ID J:206743]

Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. [PubMed: 22664870]  [MGI Ref ID J:188934]

Krueger A; von Boehmer H. 2007. Identification of a T lineage-committed progenitor in adult blood. Immunity 26(1):105-16. [PubMed: 17222572]  [MGI Ref ID J:118201]

Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PubMed: 18691745]  [MGI Ref ID J:142409]

Kuroda-Morimoto M; Tanaka H; Hayashi N; Nakahira M; Imai Y; Imamura M; Yasuda K; Yumikura-Futatsugi S; Matsui K; Nakashima T; Sugimura K; Tsutsui H; Sano H; Nakanishi K. 2010. Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. Int Immunol 22(7):561-70. [PubMed: 20497957]  [MGI Ref ID J:161302]

Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. [PubMed: 23686485]  [MGI Ref ID J:204842]

Li L; Wang L; Li L; Wang Z; Ho Y; McDonald T; Holyoake TL; Chen W; Bhatia R. 2012. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib. Cancer Cell 21(2):266-81. [PubMed: 22340598]  [MGI Ref ID J:181458]

Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. [PubMed: 20713716]  [MGI Ref ID J:163745]

Long BR; Stoddart CA. 2012. Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice. J Virol 86(6):3327-36. [PubMed: 22238321]  [MGI Ref ID J:181199]

Lu L; Ikizawa K; Hu D; Werneck MB; Wucherpfennig KW; Cantor H. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26(5):593-604. [PubMed: 17509909]  [MGI Ref ID J:123555]

Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. [PubMed: 19481135]  [MGI Ref ID J:151435]

Ma S; Shukla V; Fang L; Gould KA; Joshi SS; Lu R. 2013. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. J Biol Chem 288(37):26430-40. [PubMed: 23897826]  [MGI Ref ID J:203533]

Ma S; Turetsky A; Trinh L; Lu R. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J Immunol 177(11):7898-904. [PubMed: 17114461]  [MGI Ref ID J:140693]

Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. [PubMed: 20472832]  [MGI Ref ID J:164541]

Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. [PubMed: 18371405]  [MGI Ref ID J:142413]

Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. [PubMed: 23659714]  [MGI Ref ID J:202643]

Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. [PubMed: 22072769]  [MGI Ref ID J:179389]

Martinez-Forero I; Azpilikueta A; Bolanos-Mateo E; Nistal-Villan E; Palazon A; Teijeira A; Perez-Chacon G; Morales-Kastresana A; Murillo O; Jure-Kunkel M; Zapata JM; Melero I. 2013. T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J Immunol 190(12):6694-706. [PubMed: 23690480]  [MGI Ref ID J:204832]

Martins VC; Busch K; Juraeva D; Blum C; Ludwig C; Rasche V; Lasitschka F; Mastitsky SE; Brors B; Hielscher T; Fehling HJ; Rodewald HR. 2014. Cell competition is a tumour suppressor mechanism in the thymus. Nature 509(7501):465-70. [PubMed: 24828041]  [MGI Ref ID J:210588]

Martins VC; Ruggiero E; Schlenner SM; Madan V; Schmidt M; Fink PJ; von Kalle C; Rodewald HR. 2012. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med 209(8):1409-17. [PubMed: 22778389]  [MGI Ref ID J:189166]

Masse GX; Corcuff E; Decaluwe H; Bommhardt U; Lantz O; Buer J; Di Santo JP. 2007. gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells. Eur J Immunol 37(9):2606-16. [PubMed: 17683114]  [MGI Ref ID J:124346]

McCaughtry TM; Etzensperger R; Alag A; Tai X; Kurtulus S; Park JH; Grinberg A; Love P; Feigenbaum L; Erman B; Singer A. 2012. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209(12):2263-76. [PubMed: 23109710]  [MGI Ref ID J:190889]

McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. [PubMed: 20404133]  [MGI Ref ID J:162809]

Merck E; Voyle RB; MacDonald HR. 2009. Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth. J Immunol 182(1):183-92. [PubMed: 19109149]  [MGI Ref ID J:143041]

Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383]  [MGI Ref ID J:87075]

Moro K; Yamada T; Tanabe M; Takeuchi T; Ikawa T; Kawamoto H; Furusawa J; Ohtani M; Fujii H; Koyasu S. 2010. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463(7280):540-4. [PubMed: 20023630]  [MGI Ref ID J:156764]

Morris SC; Orekhova T; Meadows MJ; Heidorn SM; Yang J; Finkelman FD. 2006. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176(9):5299-305. [PubMed: 16621996]  [MGI Ref ID J:131660]

Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. [PubMed: 19535452]  [MGI Ref ID J:153922]

Mukai K; Matsuoka K; Taya C; Suzuki H; Yokozeki H; Nishioka K; Hirokawa K; Etori M; Yamashita M; Kubota T; Minegishi Y; Yonekawa H; Karasuyama H. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23(2):191-202. [PubMed: 16111637]  [MGI Ref ID J:100537]

Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. [PubMed: 22791816]  [MGI Ref ID J:192954]

Nakajima H; Leonard WJ. 1997. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice. J Immunol 159(10):4737-44. [PubMed: 9366397]  [MGI Ref ID J:43962]

Nakajima H; Leonard WJ. 1999. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol 162(2):782-90. [PubMed: 9916699]  [MGI Ref ID J:52019]

Nakajima H; Shores EW; Noguchi M; Leonard WJ. 1997. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 185(2):189-95. [PubMed: 9016868]  [MGI Ref ID J:107159]

Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. [PubMed: 20805496]  [MGI Ref ID J:164365]

Nolte T; Zadeh-Khorasani M; Safarov O; Rueff F; Varga R; Herbach N; Wanke R; Wollenberg A; Mueller T; Gropp R; Wolf E; Siebeck M. 2013. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech 6(1):125-34. [PubMed: 22822046]  [MGI Ref ID J:192789]

Nozad Charoudeh H; Tang Y; Cheng M; Cilio CM; Jacobsen SE; Sitnicka E. 2010. Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood 116(2):183-92. [PubMed: 20421450]  [MGI Ref ID J:162802]

O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. [PubMed: 22392992]  [MGI Ref ID J:182231]

O'Leary JG; Goodarzi M; Drayton DL; von Andrian UH. 2006. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7(5):507-16. [PubMed: 16617337]  [MGI Ref ID J:112596]

O'Sullivan T; Saddawi-Konefka R; Vermi W; Koebel CM; Arthur C; White JM; Uppaluri R; Andrews DM; Ngiow SF; Teng MW; Smyth MJ; Schreiber RD; Bui JD. 2012. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med 209(10):1869-82. [PubMed: 22927549]  [MGI Ref ID J:192935]

Ohteki T; Suzue K; Maki C; Ota T; Koyasu S. 2001. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol 2(12):1138-43. [PubMed: 11702064]  [MGI Ref ID J:125660]

Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. [PubMed: 22430210]  [MGI Ref ID J:193369]

Orr SJ; Roessler S; Quigley L; Chan T; Ford JW; O'Connor GM; McVicar DW. 2010. Implications for gene therapy-limiting expression of IL-2Rgammac delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol 185(3):1393-403. [PubMed: 20592278]  [MGI Ref ID J:162459]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Ozturk F; Li Y; Zhu X; Guda C; Nawshad A. 2013. Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFbeta3-knockout mice alleles: RNA-Seq analysis of TGFbeta3 Mice. BMC Genomics 14:113. [PubMed: 23421592]  [MGI Ref ID J:196701]

Park H; Tsang M; Iritani BM; Bevan MJ. 2014. Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A 111(19):7066-71. [PubMed: 24785297]  [MGI Ref ID J:211065]

Paust S; Gill HS; Wang BZ; Flynn MP; Moseman EA; Senman B; Szczepanik M; Telenti A; Askenase PW; Compans RW; von Andrian UH. 2010. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 11(12):1127-35. [PubMed: 20972432]  [MGI Ref ID J:167327]

Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. [PubMed: 18491294]  [MGI Ref ID J:151386]

Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PubMed: 18563383]  [MGI Ref ID J:138005]

Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. [PubMed: 18785974]  [MGI Ref ID J:140388]

Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. [PubMed: 22340590]  [MGI Ref ID J:181463]

Porcellini S; Traggiai E; Schenk U; Ferrera D; Matteoli M; Lanzavecchia A; Michalak M; Grassi F. 2006. Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-71. [PubMed: 16492806]  [MGI Ref ID J:119147]

Porter BO; Malek TR. 1999. IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development. J Immunol 163(11):5906-12. [PubMed: 10570276]  [MGI Ref ID J:58655]

Price AE; Liang HE; Sullivan BM; Reinhardt RL; Eisley CJ; Erle DJ; Locksley RM. 2010. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A 107(25):11489-94. [PubMed: 20534524]  [MGI Ref ID J:161387]

Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. [PubMed: 23933255]  [MGI Ref ID J:201893]

Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. [PubMed: 19052619]  [MGI Ref ID J:142408]

Ramirez-Carrozzi V; Sambandam A; Luis E; Lin Z; Jeet S; Lesch J; Hackney J; Kim J; Zhou M; Lai J; Modrusan Z; Sai T; Lee W; Xu M; Caplazi P; Diehl L; de Voss J; Balazs M; Gonzalez L Jr; Singh H; Ouyang W; Pappu R. 2011. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12(12):1159-66. [PubMed: 21993848]  [MGI Ref ID J:178967]

Ramsey C; Rubinstein MP; Kim DM; Cho JH; Sprent J; Surh CD. 2008. The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol 180(8):5320-6. [PubMed: 18390713]  [MGI Ref ID J:134238]

Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. [PubMed: 22542847]  [MGI Ref ID J:184798]

Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. [PubMed: 21209895]  [MGI Ref ID J:168312]

Rodgers JT; King KY; Brett JO; Cromie MJ; Charville GW; Maguire KK; Brunson C; Mastey N; Liu L; Tsai CR; Goodell MA; Rando TA. 2014. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature 510(7505):393-6. [PubMed: 24870234]  [MGI Ref ID J:213273]

Rosenberger CM; Clark AE; Treuting PM; Johnson CD; Aderem A. 2008. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A 105(7):2544-9. [PubMed: 18268321]  [MGI Ref ID J:132172]

Rothfuchs AG; Trumstedt C; Wigzell H; Rottenberg ME. 2004. Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling. J Immunol 172(10):6345-53. [PubMed: 15128825]  [MGI Ref ID J:89856]

Sabet-Baktach M; Eggenhofer E; Rovira J; Renner P; Lantow M; Farkas SA; Malaise M; Edtinger K; Shaotang Z; Koehl GE; Dahlke MH; Schlitt HJ; Geissler EK; Kroemer A. 2013. Double deficiency for RORgammat and T-bet drives Th2-mediated allograft rejection in mice. J Immunol 191(8):4440-6. [PubMed: 24058178]  [MGI Ref ID J:206252]

Saint Fleur S; Hoshino A; Kondo K; Egawa T; Fujii H. 2009. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood 114(7):1355-65. [PubMed: 19528538]  [MGI Ref ID J:151722]

Sander S; Calado DP; Srinivasan L; Kochert K; Zhang B; Rosolowski M; Rodig SJ; Holzmann K; Stilgenbauer S; Siebert R; Bullinger L; Rajewsky K. 2012. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22(2):167-79. [PubMed: 22897848]  [MGI Ref ID J:191824]

Sanos SL; Bui VL; Mortha A; Oberle K; Heners C; Johner C; Diefenbach A. 2009. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 10(1):83-91. [PubMed: 19029903]  [MGI Ref ID J:142348]

Schwab I; Biburger M; Kronke G; Schett G; Nimmerjahn F. 2012. IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol 42(4):826-30. [PubMed: 22278120]  [MGI Ref ID J:187786]

Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. [PubMed: 19636062]  [MGI Ref ID J:152910]

Serafini N; Klein Wolterink RG; Satoh-Takayama N; Xu W; Vosshenrich CA; Hendriks RW; Di Santo JP. 2014. Gata3 drives development of RORgammat+ group 3 innate lymphoid cells. J Exp Med 211(2):199-208. [PubMed: 24419270]  [MGI Ref ID J:208346]

Shang L; Hua H; Foo K; Martinez H; Watanabe K; Zimmer M; Kahler DJ; Freeby M; Chung W; LeDuc C; Goland R; Leibel RL; Egli D. 2014. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63(3):923-33. [PubMed: 24227685]  [MGI Ref ID J:208989]

Shukla V; Ma S; Hardy RR; Joshi SS; Lu R. 2013. A role for IRF4 in the development of CLL. Blood 122(16):2848-55. [PubMed: 23926303]  [MGI Ref ID J:203270]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151]  [MGI Ref ID J:109833]

Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. [PubMed: 20615947]  [MGI Ref ID J:162315]

Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. [PubMed: 18453623]  [MGI Ref ID J:142412]

Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. [PubMed: 22371883]  [MGI Ref ID J:183769]

Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. [PubMed: 23643966]  [MGI Ref ID J:202381]

Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. [PubMed: 20671122]  [MGI Ref ID J:167434]

Strowig T; Gurer C; Ploss A; Liu YF; Arrey F; Sashihara J; Koo G; Rice CM; Young JW; Chadburn A; Cohen JI; Munz C. 2009. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 206(6):1423-34. [PubMed: 19487422]  [MGI Ref ID J:149509]

Suzuki K; Nakajima H; Saito Y; Saito T; Leonard WJ; Iwamoto I. 2000. Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. Int Immunol 12(2):123-32. [PubMed: 10653847]  [MGI Ref ID J:60418]

Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. [PubMed: 20634377]  [MGI Ref ID J:165866]

Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. [PubMed: 22279057]  [MGI Ref ID J:180274]

Takatori H; Kanno Y; Watford WT; Tato CM; Weiss G; Ivanov II; Littman DR; O'Shea JJ. 2009. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206(1):35-41. [PubMed: 19114665]  [MGI Ref ID J:144034]

Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. [PubMed: 22611244]  [MGI Ref ID J:188959]

Tanno T; Lim Y; Wang Q; Chesi M; Bergsagel PL; Matthews G; Johnstone RW; Ghosh N; Borrello I; Huff CA; Matsui W. 2014. Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells. Blood 123(5):725-33. [PubMed: 24345755]  [MGI Ref ID J:208701]

Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 209(11):2065-77. [PubMed: 23071255]  [MGI Ref ID J:190897]

Taylor RT; Lugering A; Newell KA; Williams IR. 2004. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol 173(12):7183-9. [PubMed: 15585839]  [MGI Ref ID J:94865]

Thomas MF; Abdul-Wajid S; Panduro M; Babiarz JE; Rajaram M; Woodruff P; Lanier LL; Heissmeyer V; Ansel KM. 2012. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood 120(1):130-42. [PubMed: 22613798]  [MGI Ref ID J:189125]

Thomas SY; Scanlon ST; Griewank KG; Constantinides MG; Savage AK; Barr KA; Meng F; Luster AD; Bendelac A. 2011. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med 208(6):1179-88. [PubMed: 21624939]  [MGI Ref ID J:176822]

Tolar J; Wang X; Braunlin E; McElmurry RT; Nakamura Y; Bell S; Xia L; Zhang J; Hu Q; Panoskaltsis-Mortari A; Zhang J; Blazar BR. 2007. The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia. Exp Hematol 35(4):682-90. [PubMed: 17379078]  [MGI Ref ID J:123112]

Torreggiani E; Matthews BG; Pejda S; Matic I; Horowitz MC; Grcevic D; Kalajzic I. 2013. Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts. PLoS One 8(9):e75204. [PubMed: 24040401]  [MGI Ref ID J:207546]

Touma M; Sun ZY; Clayton LK; Marissen WE; Kruisbeek AM; Wagner G; Reinherz EL. 2007. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol 178(6):3668-79. [PubMed: 17339464]  [MGI Ref ID J:144281]

Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. [PubMed: 19369639]  [MGI Ref ID J:151270]

Unzu C; Melero I; Morales-Kastresana A; Sampedro A; Serrano-Mendioroz I; Azpilikueta A; Ochoa MC; Dubrot J; Martinez-Anso E; Fontanellas A. 2014. Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One 9(1):e85432. [PubMed: 24465560]  [MGI Ref ID J:212341]

Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350]  [MGI Ref ID J:134359]

Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. [PubMed: 21875955]  [MGI Ref ID J:177573]

Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. [PubMed: 20430958]  [MGI Ref ID J:162797]

Wallington-Beddoe CT; Powell JA; Tong D; Pitson SM; Bradstock KF; Bendall LJ. 2014. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res 74(10):2803-15. [PubMed: 24686171]  [MGI Ref ID J:212466]

Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. [PubMed: 24516154]  [MGI Ref ID J:206819]

Waskow C; Bartels S; Schlenner SM; Costa C; Rodewald HR. 2007. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood 109(12):5363-70. [PubMed: 17327401]  [MGI Ref ID J:145426]

Wei C; Zeff R; Goldschneider I. 2000. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. J Immunol 164(4):1961-70. [PubMed: 10657646]  [MGI Ref ID J:60331]

White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. [PubMed: 22406538]  [MGI Ref ID J:184554]

Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60(6):1726-33. [PubMed: 21521873]  [MGI Ref ID J:177952]

Wilhelm C; Hirota K; Stieglitz B; Van Snick J; Tolaini M; Lahl K; Sparwasser T; Helmby H; Stockinger B. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071-7. [PubMed: 21983833]  [MGI Ref ID J:177640]

Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123(3):1032-43. [PubMed: 23454765]  [MGI Ref ID J:196378]

Wu X; Kastin AJ; Hsuchou H; Pan W. 2010. The effects of IL2Rgamma knockout on depression and contextual memory. Behav Brain Res 213(2):319-22. [PubMed: 20438766]  [MGI Ref ID J:161861]

Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. [PubMed: 20686503]  [MGI Ref ID J:166359]

Xie H; Xu J; Hsu JH; Nguyen M; Fujiwara Y; Peng C; Orkin SH. 2014. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 14(1):68-80. [PubMed: 24239285]  [MGI Ref ID J:205522]

Xie Y; Akpinarli A; Maris C; Hipkiss EL; Lane M; Kwon EK; Muranski P; Restifo NP; Antony PA. 2010. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med 207(3):651-67. [PubMed: 20156973]  [MGI Ref ID J:158128]

Xu X; Weiss ID; Zhang HH; Singh SP; Wynn TA; Wilson MS; Farber JM. 2014. Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol 192(4):1778-86. [PubMed: 24442439]  [MGI Ref ID J:209361]

XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. [PubMed: 19805087]  [MGI Ref ID J:153698]

Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106(9):3227-33. [PubMed: 16020505]  [MGI Ref ID J:123902]

Yamauchi T; Takenaka K; Urata S; Shima T; Kikushige Y; Tokuyama T; Iwamoto C; Nishihara M; Iwasaki H; Miyamoto T; Honma N; Nakao M; Matozaki T; Akashi K. 2013. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood 121(8):1316-25. [PubMed: 23293079]  [MGI Ref ID J:194763]

Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. [PubMed: 21724588]  [MGI Ref ID J:175446]

Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74(4):1022-31. [PubMed: 24356421]  [MGI Ref ID J:208172]

Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. [PubMed: 23348745]  [MGI Ref ID J:194482]

Yu G; Xu X; Vu MD; Kilpatrick ED; Li XC. 2006. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 203(8):1851-8. [PubMed: 16864660]  [MGI Ref ID J:124395]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zecher D; Li Q; Oberbarnscheidt MH; Demetris AJ; Shlomchik WD; Rothstein DM; Lakkis FG. 2010. NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells. J Immunol 184(12):6649-57. [PubMed: 20483732]  [MGI Ref ID J:161405]

Zenewicz LA; Yancopoulos GD; Valenzuela DM; Murphy AJ; Stevens S; Flavell RA. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29(6):947-57. [PubMed: 19100701]  [MGI Ref ID J:142640]

Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. [PubMed: 20478526]  [MGI Ref ID J:160523]

Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. [PubMed: 21368761]  [MGI Ref ID J:170816]

Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. [PubMed: 20668064]  [MGI Ref ID J:164245]

Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. [PubMed: 20691153]  [MGI Ref ID J:164900]

Zhou S; Mody D; DeRavin SS; Hauer J; Lu T; Ma Z; Hacein-Bey Abina S; Gray JT; Greene MR; Cavazzana-Calvo M; Malech HL; Sorrentino BP. 2010. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood 116(6):900-8. [PubMed: 20457870]  [MGI Ref ID J:163500]

van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. [PubMed: 23690475]  [MGI Ref ID J:204834]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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