Strain Name:

FVB.Cg-Tg(Myh6-tTA)6Smbf/J

Stock Number:

003170

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Availability:

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Use Restrictions Apply, see Terms of Use
This strain may be useful for generating conditional expression of target genes in cardiac myocytes.

Description

Strain Information

Former Names FVB/N-Tg(MHCAtTA)6Smbf/J    (Changed: 21-NOV-07 )
Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHemizygote x Noncarrier         (Female x Male)   05-OCT-12
Specieslaboratory mouse
Generation?pN1+F2 (21-AUG-14)
Generation Definitions
 
Donating InvestigatorDr. Glenn I. Fishman,   NYU School of Medicine

Appearance
albino
Related Genotype: Tyrc/Tyrc

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Description
This strain expresses the tetracycline-controlled transactivator protein (tTA) under the regulatory control of the rat alpha myosin heavy chain promoter, which directs expression of tTA, specifically, in cardiac myocytes. When these Myh6-tTA (also called 2.9alphatTA or MHCAtTA) transgenic mice are mated to a second transgenic strain carrying a gene of interest coupled to a tetracycline-responsive promoter element (TRE), conditional expression of the target gene in cardiac myocytes may be controlled by the administration of tetracycline or doxycycline.

Development
A transgene in which ~ 2.9kb of 5' flanking sequence from the rat alpha myosin heavy chain gene drives expression of the tetracycline-controlled transactivator (tTA) was microinjected into C57BL/6xCBA F1 hybrid pronuclei. Subsequently, the strain was backcrossed to FVB/N for at least 8 generations.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

Strains carrying other alleles of Myh6
014154   FVB-Tg(Myh6/tetO-Itpr2)4.9Jmol/J
View Strains carrying other alleles of Myh6     (1 strain)

View Strains carrying other alleles of Pde6b     (13 strains)

Strains carrying other alleles of tTA
008079   129S-Ppargtm2Yba/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
009602   B6.129S4(Cg)-Kcnn2tm2Jpad/J
009603   B6.129S4-Kcnn3tm1Jpad/J
008227   B6.129S4-Ppargtm3Yba/J
012359   B6.Cg-Pvalbtm1.1(tTA2)Hze/J
016868   B6.Cg-Ssttm1.2(tTA2)Hze/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003563   B6.Cg-Tg(Cebpb-tTA)5Bjd/J
003767   B6.Cg-Tg(Eno2tTA)5021Nes/J
003763   B6.Cg-Tg(Eno2tTA)5030Nes/J
018306   B6.Cg-Tg(Fos-tTA,Fos-EGFP*)1Mmay/J
005964   B6.Cg-Tg(GFAP-tTA)110Pop/J
002618   B6.Cg-Tg(MMTVtTA)1Mam/J
008284   B6.Cg-Tg(Scg2-tTA)1Jt/J
023970   B6.Cg-Tg(Sirpa-tTA)AUmri/J
023971   B6.Cg-Tg(Sirpa-tTA)SUmri/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
017722   B6.Cg-Tg(Tal1-tTA)19Dgt/J
017754   B6;129-Omptm1(tTA)Gogo/J
007585   B6;129S4-Npytm2Rpa/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
003010   B6;CBA-Tg(Camk2a-tTA)1Mmay/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
010573   B6;SJL-Tg(Prl-tTA)6-5Jek/J
008082   B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
010712   C57BL/6-Tg(Camk2a-tTA)1Stl/J
013585   FVB-Tg(Cdh5-tTA)D5Lbjn/J
005625   FVB-Tg(Pcp2-tTA)3Horr/J
006209   FVB.Cg-Tg(Tal1-tTA)19Dgt/J
005942   FVB/N-Tg(Pf4-tTA/VP16)42Kra/J
004937   NOD.Cg-Tg(Ins2-tTA)1Doi/DoiJ
006999   STOCK Dbttm1Geh Tg(Cebpb-tTA)5Bjd Tg(tetO-DBT)A1Geh/J
008335   STOCK Foxa2tm1.1(rtTa)Moon/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
005701   STOCK Pdx1tm1Macd/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
003271   STOCK Tg(CMV-tTA)3Bjd/J
024854   STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*P301L)#Kha/J
018124   STOCK Tg(Prnp-tTA)F959Sbp/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
003275   STOCK Tg(tetL)1Bjd/J
003274   STOCK Tg(tetNZL)2Bjd/J
016970   STOCK Tg(tetO-HCV)1Mlch/Mmjax
View Strains carrying other alleles of tTA     (46 strains)

Additional Web Information

Tet Expression Systems

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cardiovascular Research
Tet Expression Systems
      tTA/rtTA Expressing Strains

Pde6brd1 related

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Myh6-tTA)6Smbf
Allele Name transgene insertion 6, Section of Myocardial Biology - Fishman Lab
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) 2.9alphatTA; Tg(MHCAtTA)6Smbf; alphaMHC-tTA; alphaMtTA;
Mutation Made ByDr. Glenn Fishman,   NYU School of Medicine
Strain of Origin(C57BL/6 x CBA)F1
Site of ExpressionExpresses tTA in cardiac myocytes.
Expressed Gene tTA, tetracycline-controlled transactivator, E. coli
The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter.
Promoter Myh6, myosin, heavy chain 6, cardiac muscle, alpha, rat
General Note Transgenic line 6 showed the strongest cardiac transgene expression and was used for analysis.

Phenotypic Similarity to Human Syndrome: Cardiomyopathy, Dilated in mice containing the Tg(tetO-Spp1)5Gad and Tg(Myh6-tTA)6Smbf transgenes (J:194810).

Molecular Note The transgene consists of a rat Myh6 promoter and a tetracycline transactivator sequence. Transgene expression in cardiac tissue was confirmed by Northern blot analysis. 2.9 kb of rat Myh6 promoter sequences directs transgene expression in the heart starting at embryonic day E7.5. [MGI Ref ID J:82692]
 
 
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]

Genotyping

Genotyping Information

Genotyping Protocols

Tg(tTA),

MELT


Tg(tTA),

Probe


Tg(tTA), QPCR
Tg(tTA), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Pde6brd1 related

Acosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270]  [MGI Ref ID J:103970]

Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569]  [MGI Ref ID J:151412]

Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735]  [MGI Ref ID J:133024]

Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. [PubMed: 17471069]  [MGI Ref ID J:122802]

Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain 130(Pt 4):1029-42. [PubMed: 17314202]  [MGI Ref ID J:154966]

Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus. J Neurosci 31(46):16833-43. [PubMed: 22090509]  [MGI Ref ID J:177906]

Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. [PubMed: 21124780]  [MGI Ref ID J:167121]

Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. [PubMed: 15451375]  [MGI Ref ID J:92980]

Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. [PubMed: 16626665]  [MGI Ref ID J:109668]

Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. [PubMed: 15003290]  [MGI Ref ID J:121036]

Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol Dis :. [PubMed: 18573342]  [MGI Ref ID J:136304]

Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. [PubMed: 15889014]  [MGI Ref ID J:98579]

Audo I; Bujakowska K; Orhan E; Poloschek CM; Defoort-Dhellemmes S; Drumare I; Kohl S; Luu TD; Lecompte O; Zrenner E; Lancelot ME; Antonio A; Germain A; Michiels C; Audier C; Letexier M; Saraiva JP; Leroy BP; Munier FL; Mohand-Said S; Lorenz B; Friedburg C; Preising M; Kellner U; Renner AB; Moskova-Doumanova V; Berger W; Wissinger B; Hamel CP; Schorderet DF; De Baere E; Sharon D; Banin E; Jacobson SG; Bonneau D; Zanlonghi X; Le Meur G; Casteels I; Koenekoop R; Long VW; Meire F; Prescott K; de Ravel T; Simm. 2012. Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90(2):321-30. [PubMed: 22325361]  [MGI Ref ID J:196741]

Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. [PubMed: 16503160]  [MGI Ref ID J:108601]

BRUCKNER R. 1951. [Slit-lamp microscopy and ophthalmoscopy in rat and mouse.] Doc Ophthalmol 5-6:452-554. [PubMed: 14896883]  [MGI Ref ID J:25576]

Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. [PubMed: 11980879]  [MGI Ref ID J:80080]

Barabas P; Liu A; Xing W; Chen CK; Tong Z; Watt CB; Jones BW; Bernstein PS; Krizaj D. 2013. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A 110(13):5181-6. [PubMed: 23479632]  [MGI Ref ID J:194246]

Barber AC; Hippert C; Duran Y; West EL; Bainbridge JW; Warre-Cornish K; Luhmann UF; Lakowski J; Sowden JC; Ali RR; Pearson RA. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A 110(1):354-9. [PubMed: 23248312]  [MGI Ref ID J:192521]

Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. [PubMed: 16600853]  [MGI Ref ID J:122947]

Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. [PubMed: 864040]  [MGI Ref ID J:5812]

Borowska J; Trenholm S; Awatramani GB. 2011. An intrinsic neural oscillator in the degenerating mouse retina. J Neurosci 31(13):5000-12. [PubMed: 21451038]  [MGI Ref ID J:171202]

Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. [PubMed: 2481314]  [MGI Ref ID J:10184]

Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. [PubMed: 1977087]  [MGI Ref ID J:10777]

Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. [PubMed: 8385352]  [MGI Ref ID J:4366]

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Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. [PubMed: 9054517]  [MGI Ref ID J:39262]

Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408]  [MGI Ref ID J:59343]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

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Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. [PubMed: 23800770]  [MGI Ref ID J:198916]

Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. Invest Ophthalmol Vis Sci 53(2):1066-75. [PubMed: 22169101]  [MGI Ref ID J:191520]

Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. [PubMed: 19131628]  [MGI Ref ID J:143166]

Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A :. [PubMed: 19966223]  [MGI Ref ID J:155817]

Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani GB; Kalloniatis M. 2013. Early remodeling of Muller cells in the rd/rd mouse model of retinal dystrophy. J Comp Neurol 521(11):2439-53. [PubMed: 23348616]  [MGI Ref ID J:200732]

Cohen AI; Blazynski C. 1990. Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors. Vis Neurosci 4(1):43-52. [PubMed: 1702315]  [MGI Ref ID J:78184]

Cornett A; Sucic JF; Hillsburg D; Cyr L; Johnson C; Polanco A; Figuereo J; Cabine K; Russo N; Sturtevant A; Jarvinen MK. 2011. Altered glial gene expression, density, and architecture in the visual cortex upon retinal degeneration. Brain Res 1422:46-56. [PubMed: 21983206]  [MGI Ref ID J:179028]

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Yoshimura T; Ebihara S. 1996. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. J Comp Physiol [A] 178(6):797-802. [PubMed: 8667293]  [MGI Ref ID J:33685]

Yoshimura T; Nishio M; Goto M; Ebihara S. 1994. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). J Biol Rhythms 9(1):51-60. [PubMed: 7949306]  [MGI Ref ID J:19351]

Yoshimura T; Yokota Y; Ishikawa A; Yasuo S; Hayashi N; Suzuki T; Okabayashi N; Namikawa T; Ebihara S. 2002. Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms 17(6):512-9. [PubMed: 12465884]  [MGI Ref ID J:80788]

Zeiss CJ; Johnson EA. 2004. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Invest Ophthalmol Vis Sci 45(3):971-6. [PubMed: 14985319]  [MGI Ref ID J:109731]

Zeiss CJ; Neal J; Johnson EA. 2004. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45(3):964-70. [PubMed: 14985318]  [MGI Ref ID J:88367]

Zencak D; Crippa SV; Tekaya M; Tanger E; Schorderet DE; Munier FL; van Lohuizen M; Arsenijevic Y. 2006. BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 572:209-15. [PubMed: 17249577]  [MGI Ref ID J:154016]

Zencak D; Schouwey K; Chen D; Ekstrom P; Tanger E; Bremner R; van Lohuizen M; Arsenijevic Y. 2013. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 110(7):E593-601. [PubMed: 23359713]  [MGI Ref ID J:194322]

Zeng HY; Lu QJ; Liu Q; Liu KG; Wang NL. 2011. The role of CCR1 expression in the retinal degeneration in rd mice. Curr Eye Res 36(3):264-9. [PubMed: 21275605]  [MGI Ref ID J:179793]

Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. [PubMed: 23221340]  [MGI Ref ID J:194158]

Zhu Y; Tu DC; Denner D; Shane T; Fitzgerald CM; Van Gelder RN. 2007. Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses. Invest Ophthalmol Vis Sci 48(3):1268-75. [PubMed: 17325172]  [MGI Ref ID J:123259]

Tg(Myh6-tTA)6Smbf related

Ainscough JF; Drinkhill MJ; Sedo A; Turner NA; Brooke DA; Balmforth AJ; Ball SG. 2009. Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res 81(3):592-600. [PubMed: 18703536]  [MGI Ref ID J:162208]

Baker AJ; Redfern CH; Harwood MD; Simpson PC; Conklin BR. 2001. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 280(4):H1653-9. [PubMed: 11247776]  [MGI Ref ID J:128598]

Barandon L; Dufourcq P; Costet P; Moreau C; Allieres C; Daret D; Dos Santos P; Daniel Lamaziere JM; Couffinhal T; Duplaa C. 2005. Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning. Circ Res 96(12):1299-306. [PubMed: 15920021]  [MGI Ref ID J:110294]

Berry JM; Le V; Rotter D; Battiprolu PK; Grinsfelder B; Tannous P; Burchfield JS; Czubryt M; Backs J; Olson EN; Rothermel BA; Hill JA. 2011. Reversibility of adverse, calcineurin-dependent cardiac remodeling. Circ Res 109(4):407-17. [PubMed: 21700928]  [MGI Ref ID J:186602]

Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM. 1997. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100(9):2189-95. [PubMed: 9410895]  [MGI Ref ID J:43986]

Burkard N; Rokita AG; Kaufmann SG; Hallhuber M; Wu R; Hu K; Hofmann U; Bonz A; Frantz S; Cartwright EJ; Neyses L; Maier LS; Maier SK; Renne T; Schuh K; Ritter O. 2007. Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res 100(3):e32-44. [PubMed: 17272813]  [MGI Ref ID J:133706]

Burkard N; Williams T; Czolbe M; Blomer N; Panther F; Link M; Fraccarollo D; Widder JD; Hu K; Han H; Hofmann U; Frantz S; Nordbeck P; Bulla J; Schuh K; Ritter O. 2010. Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia/reperfusion. Circulation 122(16):1588-603. [PubMed: 20921441]  [MGI Ref ID J:179484]

Callis TE; Pandya K; Seok HY; Tang RH; Tatsuguchi M; Huang ZP; Chen JF; Deng Z; Gunn B; Shumate J; Willis MS; Selzman CH; Wang DZ. 2009. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 119(9):2772-86. [PubMed: 19726871]  [MGI Ref ID J:152696]

Czubryt MP; McAnally J; Fishman GI; Olson EN. 2003. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A 100(4):1711-6. [PubMed: 12578979]  [MGI Ref ID J:81967]

Dalal S; Zha Q; Daniels CR; Steagall RJ; Joyner WL; Gadeau AP; Singh M; Singh K. 2014. Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol 306(8):H1182-91. [PubMed: 24531809]  [MGI Ref ID J:210479]

Dor Y; Camenisch TD; Itin A; Fishman GI; McDonald JA; Carmeliet P; Keshet E. 2001. A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128(9):1531-8. [PubMed: 11290292]  [MGI Ref ID J:68214]

Elsherif L; Wang X; Grachoff M; Wolska BM; Geenen DL; O'Bryan JP. 2012. Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury. PLoS One 7(1):e30129. [PubMed: 22272284]  [MGI Ref ID J:179877]

Favre J; Gao J; Di Zang A; Remy-Jouet I; Ouvrard-Pascaud A; Dautreaux B; Escoubet B; Thuillez C; Jaisser F; Richard V. 2011. Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression. Am J Physiol Heart Circ Physiol :. [PubMed: 21441311]  [MGI Ref ID J:170305]

Gao MH; Bayat H; Roth DM; Yao Zhou J; Drumm J; Burhan J; Hammond HK. 2002. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res 56(2):197-204. [PubMed: 12393090]  [MGI Ref ID J:132260]

Gellen B; Fernandez-Velasco M; Briec F; Vinet L; LeQuang K; Rouet-Benzineb P; Benitah JP; Pezet M; Palais G; Pellegrin N; Zhang A; Perrier R; Escoubet B; Marniquet X; Richard S; Jaisser F; Gomez AM; Charpentier F; Mercadier JJ. 2008. Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation 117(14):1778-86. [PubMed: 18378612]  [MGI Ref ID J:153299]

Gomez AM; Rueda A; Sainte-Marie Y; Pereira L; Zissimopoulos S; Zhu X; Schaub R; Perrier E; Perrier R; Latouche C; Richard S; Picot MC; Jaisser F; Lai FA; Valdivia HH; Benitah JP. 2009. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 119(16):2179-87. [PubMed: 19364981]  [MGI Ref ID J:166494]

Grunewald M; Avraham I; Dor Y; Bachar-Lustig E; Itin A; Jung S; Chimenti S; Landsman L; Abramovitch R; Keshet E. 2006. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124(1):175-89. [PubMed: 16413490]  [MGI Ref ID J:115908]

Hirotani S; Zhai P; Tomita H; Galeotti J; Marquez JP; Gao S; Hong C; Yatani A; Avila J; Sadoshima J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101(11):1164-74. [PubMed: 17901358]  [MGI Ref ID J:142787]

Huang L; Wolska BM; Montgomery DE; Burkart EM; Buttrick PM; Solaro RJ. 2001. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta. Am J Physiol Cell Physiol 280(5):C1114-20. [PubMed: 11287324]  [MGI Ref ID J:128800]

Jaba IM; Zhuang ZW; Li N; Jiang Y; Martin KA; Sinusas AJ; Papademetris X; Simons M; Sessa WC; Young LH; Tirziu D. 2013. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest 123(4):1718-31. [PubMed: 23454748]  [MGI Ref ID J:197567]

Latouche C; Sainte-Marie Y; Steenman M; Castro Chaves P; Naray-Fejes-Toth A; Fejes-Toth G; Farman N; Jaisser F. 2010. Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart. Endocrinology 151(9):4467-76. [PubMed: 20591974]  [MGI Ref ID J:165690]

Lee P; Morley G; Huang Q; Fischer A; Seiler S; Horner JW; Factor S; Vaidya D; Jalife J; Fishman GI. 1998. Conditional lineage ablation to model human diseases. Proc Natl Acad Sci U S A 95(19):11371-6. [PubMed: 9736743]  [MGI Ref ID J:128617]

Loyer X; Gomez AM; Milliez P; Fernandez-Velasco M; Vangheluwe P; Vinet L; Charue D; Vaudin E; Zhang W; Sainte-Marie Y; Robidel E; Marty I; Mayer B; Jaisser F; Mercadier JJ; Richard S; Shah AM; Benitah JP; Samuel JL; Heymes C. 2008. Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation 117(25):3187-98. [PubMed: 18541744]  [MGI Ref ID J:155077]

Lu S; Crawford GL; Dore J; Anderson SA; Despres D; Horowits R. 2011. Cardiac-specific NRAP overexpression causes right ventricular dysfunction in mice. Exp Cell Res 317(8):1226-37. [PubMed: 21276443]  [MGI Ref ID J:170859]

Maier HJ; Schips TG; Wietelmann A; Kruger M; Brunner C; Sauter M; Klingel K; Bottger T; Braun T; Wirth T. 2012. Cardiomyocyte-specific IkappaB kinase (IKK)/NF-kappaB activation induces reversible inflammatory cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 109(29):11794-9. [PubMed: 22753500]  [MGI Ref ID J:186490]

May D; Gilon D; Djonov V; Itin A; Lazarus A; Gordon O; Rosenberger C; Keshet E. 2008. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A 105(1):282-7. [PubMed: 18162550]  [MGI Ref ID J:131069]

Mayr M; May D; Gordon O; Madhu B; Gilon D; Yin X; Xing Q; Drozdov I; Ainali C; Tsoka S; Xu Q; Griffiths J; Horrevoets A; Keshet E. 2011. Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. J Mol Cell Cardiol 50(6):982-90. [PubMed: 21354174]  [MGI Ref ID J:172827]

McCloskey DT; Turcato S; Wang GY; Turnbull L; Zhu BQ; Bambino T; Nguyen AP; Lovett DH; Nissenson RA; Karliner JS; Baker AJ. 2008. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294(1):H205-12. [PubMed: 17965283]  [MGI Ref ID J:132451]

McCloskey DT; Turnbull L; Swigart PM; Zambon AC; Turcato S; Joho S; Grossman W; Conklin BR; Simpson PC; Baker AJ. 2005. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics 22(1):118-26. [PubMed: 15797971]  [MGI Ref ID J:99311]

Montano MM; Desjardins CL; Doughman YQ; Hsieh YH; Hu Y; Bensinger HM; Wang C; Stelzer JE; Dick TE; Hoit BD; Chandler MP; Yu X; Watanabe M. 2013. Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res 99(1):74-82. [PubMed: 23585471]  [MGI Ref ID J:211395]

Mueller EE; Momen A; Masse S; Zhou YQ; Liu J; Backx PH; Henkelman RM; Nanthakumar K; Stewart DJ; Husain M. 2011. Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovasc Res 89(3):623-33. [PubMed: 21062919]  [MGI Ref ID J:186883]

Mungrue IN; Gros R; You X; Pirani A; Azad A; Csont T; Schulz R; Butany J; Stewart DJ; Husain M. 2002. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 109(6):735-43. [PubMed: 11901182]  [MGI Ref ID J:132082]

Oshima Y; Ouchi N; Sato K; Izumiya Y; Pimentel DR; Walsh K. 2008. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation 117(24):3099-108. [PubMed: 18519848]  [MGI Ref ID J:155080]

Ouvrard-Pascaud A; Sainte-Marie Y; Benitah JP; Perrier R; Soukaseum C; Cat AN; Royer A; Le Quang K; Charpentier F; Demolombe S; Mechta-Grigoriou F; Beggah AT; Maison-Blanche P; Oblin ME; Delcayre C; Fishman GI; Farman N; Escoubet B; Jaisser F. 2005. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 111(23):3025-33. [PubMed: 15939817]  [MGI Ref ID J:112171]

Palais G; Nguyen Dinh Cat A; Friedman H; Panek-Huet N; Millet A; Tronche F; Gellen B; Mercadier JJ; Peterson A; Jaisser F. 2009. Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37(2):140-6. [PubMed: 19141541]  [MGI Ref ID J:157969]

Parra V; Verdejo HE; Iglewski M; Del Campo A; Troncoso R; Jones D; Zhu Y; Kuzmicic J; Pennanen C; Lopez-Crisosto C; Jana F; Ferreira J; Noguera E; Chiong M; Bernlohr DA; Klip A; Hill JA; Rothermel BA; Abel ED; Zorzano A; Lavandero S. 2014. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFkappaB-Opa-1 signaling pathway. Diabetes 63(1):75-88. [PubMed: 24009260]  [MGI Ref ID J:208920]

Redfern CH; Coward P; Degtyarev MY; Lee EK; Kwa AT; Hennighausen L; Bujard H; Fishman GI; Conklin BR. 1999. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol 17(2):165-9. [PubMed: 10052353]  [MGI Ref ID J:95090]

Redfern CH; Degtyarev MY; Kwa AT; Salomonis N; Cotte N; Nanevicz T; Fidelman N; Desai K; Vranizan K; Lee EK; Coward P; Shah N; Warrington JA; Fishman GI; Bernstein D; Baker AJ; Conklin BR. 2000. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A 97(9):4826-31. [PubMed: 10781088]  [MGI Ref ID J:107363]

Renault MA; Robbesyn F; Reant P; Douin V; Daret D; Allieres C; Belloc I; Couffinhal T; Arnal JF; Klingel K; Desgranges C; Dos Santos P; Charpentier F; Gadeau AP. 2010. Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy. Circ Heart Fail 3(3):431-9. [PubMed: 20200330]  [MGI Ref ID J:194810]

Sainte-Marie Y; Nguyen Dinh Cat A; Perrier R; Mangin L; Soukaseum C; Peuchmaur M; Tronche F; Farman N; Escoubet B; Benitah JP; Jaisser F. 2007. Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block. FASEB J 21(12):3133-41. [PubMed: 17517920]  [MGI Ref ID J:134842]

Schiekofer S; Shiojima I; Sato K; Galasso G; Oshima Y; Walsh K. 2006. Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol Genomics 27(2):156-70. [PubMed: 16882883]  [MGI Ref ID J:113653]

Shiojima I; Sato K; Izumiya Y; Schiekofer S; Ito M; Liao R; Colucci WS; Walsh K. 2005. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 115(8):2108-18. [PubMed: 16075055]  [MGI Ref ID J:100144]

Shiojima I; Schiekofer S; Schneider JG; Belisle K; Sato K; Andrassy M; Galasso G; Walsh K. 2012. Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts. Am J Pathol 181(6):1969-76. [PubMed: 23031259]  [MGI Ref ID J:190292]

Sugano Y; Lai NC; Gao MH; Firth AL; Yuan JX; Lew WY; Hammond HK. 2011. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun 405(3):349-55. [PubMed: 21195051]  [MGI Ref ID J:170559]

Tian R; Miao W; Spindler M; Javadpour MM; McKinney R; Bowman JC; Buttrick PM; Ingwall JS. 1999. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery. Proc Natl Acad Sci U S A 96(23):13536-41. [PubMed: 10557356]  [MGI Ref ID J:58525]

Tirziu D; Chorianopoulos E; Moodie KL; Palac RT; Zhuang ZW; Tjwa M; Roncal C; Eriksson U; Fu Q; Elfenbein A; Hall AE; Carmeliet P; Moons L; Simons M. 2007. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 117(11):3188-97. [PubMed: 17975666]  [MGI Ref ID J:127379]

Turnbull L; Zhou HZ; Swigart PM; Turcato S; Karliner JS; Conklin BR; Simpson PC; Baker AJ. 2006. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol 290(3):H1103-9. [PubMed: 16243914]  [MGI Ref ID J:106717]

Vigneron F; Dos Santos P; Lemoine S; Bonnet M; Tariosse L; Couffinhal T; Duplaa C; Jaspard-Vinassa B. 2011. GSK-3beta at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways. Cardiovasc Res 90(1):49-56. [PubMed: 21233250]  [MGI Ref ID J:186008]

Voskas D; Babichev Y; Ling LS; Alami J; Shaked Y; Kerbel RS; Ciruna B; Dumont DJ. 2008. An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. J Leukoc Biol 84(1):59-67. [PubMed: 18443190]  [MGI Ref ID J:137745]

Wang ZV; Deng Y; Gao N; Pedrozo Z; Li DL; Morales CR; Criollo A; Luo X; Tan W; Jiang N; Lehrman MA; Rothermel BA; Lee AH; Lavandero S; Mammen PP; Ferdous A; Gillette TG; Scherer PE; Hill JA. 2014. Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Cell 156(6):1179-92. [PubMed: 24630721]  [MGI Ref ID J:211997]

Wittkopper K; Fabritz L; Neef S; Ort KR; Grefe C; Unsold B; Kirchhof P; Maier LS; Hasenfuss G; Dobrev D; Eschenhagen T; El-Armouche A. 2010. Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest 120(2):617-26. [PubMed: 20071777]  [MGI Ref ID J:156679]

Yang LL; Gros R; Kabir MG; Sadi A; Gotlieb AI; Husain M; Stewart DJ. 2004. Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. Circulation 109(2):255-61. [PubMed: 14718401]  [MGI Ref ID J:131245]

Yu Z; Redfern CS; Fishman GI. 1996. Conditional transgene expression in the heart. Circ Res 79(4):691-7. [PubMed: 8831492]  [MGI Ref ID J:82692]

Ziegler T; Horstkotte J; Schwab C; Pfetsch V; Weinmann K; Dietzel S; Rohwedder I; Hinkel R; Gross L; Lee S; Hu J; Soehnlein O; Franz WM; Sperandio M; Pohl U; Thomas M; Weber C; Augustin HG; Fassler R; Deutsch U; Kupatt C. 2013. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest :. [PubMed: 23863629]  [MGI Ref ID J:201411]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryWhen mating to tet responder animals, doxycycline should be administered to the female to avoid an embryonic lethal phenotype. This strain is fed normal chow diet. Expected coat color from breeding is "Albino."
Mating SystemHemizygote x Noncarrier         (Female x Male)   05-OCT-12
Diet Information LabDiet® 5K20

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Myh6-tTA)6Smbf  
Price per Pair (US dollars $)Pair Genotype
$311.00Hemizygous for Tg(Myh6-tTA)6Smbf x Noncarrier  
$311.00Noncarrier x Hemizygous for Tg(Myh6-tTA)6Smbf  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Myh6-tTA)6Smbf  
Price per Pair (US dollars $)Pair Genotype
$404.30Hemizygous for Tg(Myh6-tTA)6Smbf x Noncarrier  
$404.30Noncarrier x Hemizygous for Tg(Myh6-tTA)6Smbf  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for the retinal degeneration allele Pde6brd1.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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