Strain Name:

FVB.Cg-Tg(Myh6-tTA)6Smbf/J

Stock Number:

003170

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names FVB/N-Tg(MHCAtTA)6Smbf/J    (Changed: 21-NOV-07 )
Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN8+N1p
 
Donating Investigator Glenn Fishman,   NYU School of Medicine

Appearance
albino
Related Genotype: Tyrc/Tyrc

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Description
This strain expresses the tetracycline-controlled transactivator protein (tTA) under the regulatory control of the rat alpha myosin heavy chain promoter, which directs expression of tTA, specifically, in cardiac myocytes. When these Myh6-tTA (also called 2.9alphatTA or MHCAtTA) transgenic mice are mated to a second transgenic strain carrying a gene of interest coupled to a tetracycline-responsive promoter element (TRE), conditional expression of the target gene in cardiac myocytes may be controlled by the administration of tetracycline or doxycycline.

Development
A transgene in which ~ 2.9kb of 5' flanking sequence from the rat alpha myosin heavy chain gene drives expression of the tetracycline-controlled transactivator (tTA) was microinjected into C57BL/6xCBA F1 hybrid pronuclei. Subsequently, the strain was backcrossed to FVB/N for at least 8 generations.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
001547   C3Sn.Cg-Cm/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying   Pde6brd1     (74 strains)

View Strains carrying other alleles of Pde6b     (10 strains)

View Strains carrying other alleles of tTA     (22 strains)

Additional Web Information

Tet Expression Systems

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cardiovascular Research
Tet Expression Systems
      tTA/rtTA Expressing Strains

Pde6brd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Tg(Myh6-tTA)6Smbf
Allele Name transgene insertion 6, Section of Myocardial Biology - Fishman Lab
Allele Type Transgenic (random, expressed)
Common Name(s) 2.9alphatTA; Tg(MHCAtTA)6Smbf; alphaMHC-tTA;
Mutation Made By Glenn Fishman,   NYU School of Medicine
Strain of Origin(C57BL/6 x CBA)F1
Site of ExpressionExpresses tTA in cardiac myocytes.
Expressed Gene tTA, tetracycline-controlled transactivator, E. coli
The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter.
Promoter Myh6, myosin, heavy chain 6, cardiac muscle, alpha, rat
General Note Transgenic line 6 showed the strongest cardiac transgene expression and was used for analysis.
Molecular Note The transgene consists of a rat Myh6 promoter and a tetracycline transactivator sequence. Transgene expression in cardiac tissue was confirmed by Northern blot analysis. 2.9 kb of rat Myh6 promoter sequences directs transgene expression in the heart starting at embryonic day E7.5. [MGI Ref ID J:82692]
 
 
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;

Genotyping

Genotyping Information

Genotyping Protocols

Tg(tTA), Melt Curve Analysis
Tg(tTA), QPCR
Tg(tTA), Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Yu Z; Redfern CS; Fishman GI. 1996. Conditional transgene expression in the heart. Circ Res 79(4):691-7. [PubMed: 8831492]  [MGI Ref ID J:82692]

Additional References

Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM. 1997. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100(9):2189-95. [PubMed: 9410895]  [MGI Ref ID J:43986]

Ward NL; Van Slyke P; Sturk C; Cruz M; Dumont DJ. 2004. Angiopoietin 1 expression levels in the myocardium direct coronary vessel development. Dev Dyn 229(3):500-9. [PubMed: 14991706]  [MGI Ref ID J:88848]

Tg(Myh6-tTA)6Smbf related

Baker AJ; Redfern CH; Harwood MD; Simpson PC; Conklin BR. 2001. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 280(4):H1653-9. [PubMed: 11247776]  [MGI Ref ID J:128598]

Barandon L; Dufourcq P; Costet P; Moreau C; Allieres C; Daret D; Dos Santos P; Daniel Lamaziere JM; Couffinhal T; Duplaa C. 2005. Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning. Circ Res 96(12):1299-306. [PubMed: 15920021]  [MGI Ref ID J:110294]

Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM. 1997. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100(9):2189-95. [PubMed: 9410895]  [MGI Ref ID J:43986]

Burkard N; Rokita AG; Kaufmann SG; Hallhuber M; Wu R; Hu K; Hofmann U; Bonz A; Frantz S; Cartwright EJ; Neyses L; Maier LS; Maier SK; Renne T; Schuh K; Ritter O. 2007. Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res 100(3):e32-44. [PubMed: 17272813]  [MGI Ref ID J:133706]

Callis TE; Pandya K; Seok HY; Tang RH; Tatsuguchi M; Huang ZP; Chen JF; Deng Z; Gunn B; Shumate J; Willis MS; Selzman CH; Wang DZ. 2009. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 119(9):2772-86. [PubMed: 19726871]  [MGI Ref ID J:152696]

Dor Y; Camenisch TD; Itin A; Fishman GI; McDonald JA; Carmeliet P; Keshet E. 2001. A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128(9):1531-8. [PubMed: 11290292]  [MGI Ref ID J:68214]

Gao MH; Bayat H; Roth DM; Yao Zhou J; Drumm J; Burhan J; Hammond HK. 2002. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res 56(2):197-204. [PubMed: 12393090]  [MGI Ref ID J:132260]

Gellen B; Fernandez-Velasco M; Briec F; Vinet L; LeQuang K; Rouet-Benzineb P; Benitah JP; Pezet M; Palais G; Pellegrin N; Zhang A; Perrier R; Escoubet B; Marniquet X; Richard S; Jaisser F; Gomez AM; Charpentier F; Mercadier JJ. 2008. Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation 117(14):1778-86. [PubMed: 18378612]  [MGI Ref ID J:153299]

Grunewald M; Avraham I; Dor Y; Bachar-Lustig E; Itin A; Jung S; Chimenti S; Landsman L; Abramovitch R; Keshet E. 2006. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124(1):175-89. [PubMed: 16413490]  [MGI Ref ID J:115908]

Hirotani S; Zhai P; Tomita H; Galeotti J; Marquez JP; Gao S; Hong C; Yatani A; Avila J; Sadoshima J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101(11):1164-74. [PubMed: 17901358]  [MGI Ref ID J:142787]

Huang L; Wolska BM; Montgomery DE; Burkart EM; Buttrick PM; Solaro RJ. 2001. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta. Am J Physiol Cell Physiol 280(5):C1114-20. [PubMed: 11287324]  [MGI Ref ID J:128800]

Lee P; Morley G; Huang Q; Fischer A; Seiler S; Horner JW; Factor S; Vaidya D; Jalife J; Fishman GI. 1998. Conditional lineage ablation to model human diseases. Proc Natl Acad Sci U S A 95(19):11371-6. [PubMed: 9736743]  [MGI Ref ID J:128617]

May D; Gilon D; Djonov V; Itin A; Lazarus A; Gordon O; Rosenberger C; Keshet E. 2008. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A 105(1):282-7. [PubMed: 18162550]  [MGI Ref ID J:131069]

McCloskey DT; Turcato S; Wang GY; Turnbull L; Zhu BQ; Bambino T; Nguyen AP; Lovett DH; Nissenson RA; Karliner JS; Baker AJ. 2008. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294(1):H205-12. [PubMed: 17965283]  [MGI Ref ID J:132451]

McCloskey DT; Turnbull L; Swigart PM; Zambon AC; Turcato S; Joho S; Grossman W; Conklin BR; Simpson PC; Baker AJ. 2005. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics 22(1):118-26. [PubMed: 15797971]  [MGI Ref ID J:99311]

Mungrue IN; Gros R; You X; Pirani A; Azad A; Csont T; Schulz R; Butany J; Stewart DJ; Husain M. 2002. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 109(6):735-43. [PubMed: 11901182]  [MGI Ref ID J:132082]

Redfern CH; Degtyarev MY; Kwa AT; Salomonis N; Cotte N; Nanevicz T; Fidelman N; Desai K; Vranizan K; Lee EK; Coward P; Shah N; Warrington JA; Fishman GI; Bernstein D; Baker AJ; Conklin BR. 2000. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A 97(9):4826-31. [PubMed: 10781088]  [MGI Ref ID J:107363]

Sainte-Marie Y; Nguyen Dinh Cat A; Perrier R; Mangin L; Soukaseum C; Peuchmaur M; Tronche F; Farman N; Escoubet B; Benitah JP; Jaisser F. 2007. Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block. FASEB J 21(12):3133-41. [PubMed: 17517920]  [MGI Ref ID J:134842]

Schiekofer S; Shiojima I; Sato K; Galasso G; Oshima Y; Walsh K. 2006. Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol Genomics 27(2):156-70. [PubMed: 16882883]  [MGI Ref ID J:113653]

Shiojima I; Sato K; Izumiya Y; Schiekofer S; Ito M; Liao R; Colucci WS; Walsh K. 2005. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 115(8):2108-18. [PubMed: 16075055]  [MGI Ref ID J:100144]

Tian R; Miao W; Spindler M; Javadpour MM; McKinney R; Bowman JC; Buttrick PM; Ingwall JS. 1999. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery. Proc Natl Acad Sci U S A 96(23):13536-41. [PubMed: 10557356]  [MGI Ref ID J:58525]

Tirziu D; Chorianopoulos E; Moodie KL; Palac RT; Zhuang ZW; Tjwa M; Roncal C; Eriksson U; Fu Q; Elfenbein A; Hall AE; Carmeliet P; Moons L; Simons M. 2007. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 117(11):3188-97. [PubMed: 17975666]  [MGI Ref ID J:127379]

Turnbull L; Zhou HZ; Swigart PM; Turcato S; Karliner JS; Conklin BR; Simpson PC; Baker AJ. 2006. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol 290(3):H1103-9. [PubMed: 16243914]  [MGI Ref ID J:106717]

Voskas D; Babichev Y; Ling LS; Alami J; Shaked Y; Kerbel RS; Ciruna B; Dumont DJ. 2008. An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. J Leukoc Biol 84(1):59-67. [PubMed: 18443190]  [MGI Ref ID J:137745]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryWhen mating to tet responder animals, doxycycline should be administered to the female to avoid an embryonic lethal phenotype. This strain is fed normal chow diet. Expected coat color from breeding is "Albino."

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery of Strains Needing Progeny Testing.
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.

    Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • This strain is included in the Induced Mutant Resource Colony collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


General Terms and Conditions


Use of the Tet-System may require a license, see Licenses for Strains Using TET-System Technology.

For additional Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

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phone:207-288-6470
fax:207-288-6655

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