Strain Name: |
B6.Cg-Myo7ash1-8J/J |
|---|---|
Stock Number: |
003184 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Myo7a; Myo7ash1-8J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain C57BL/6J Donor Strain B6;SJL-TgN(c17lacZ)226Bri Generation N10F13p Appearance
black, tremors
Related Genotype: a/a Myo7ash1-8J/Myo7ash1-8J
black, unaffected
Related Genotype: a/a Myo7ash1-8J/+Strain Description
Myo7ash1-8J homozygous mice circle and bob their heads; heterozygotes are behaviorally normal. Homozygotes of both sexes are viable and fertile (Samples 2000). The hearing of Myo7ash1-8J mutants has not been examined. However, other Myo7a mutations, whose behavioral phenotypes are virtually identical to that of Myo7ash1-J, are associated with deafness.Mutations in the human ortholog of Myo7a, MYO7A, have been characterized in pedigrees of patients having Usher syndrome type 1 (USH1), an autosomal recessive disorder characterized by profound deafness, vestibular dysfunction and progressive retinitis pigmentosa (Weil et al., 1995; Weston et al., 1996; Adato et al., 1997; Levy et al., 1997; Liu et al., 1998; Espinos et al., 1998; Cuevas et al., 1998, 1999; Janecke et al., 1999). MYO7A mutations have also been identified in patients with autosomal dominant non-syndromic deafness (Liu et al., 1997) and autosomal recessive isolated deafness (Liu et al., 1997; Weil et al., 1997).
Strain Development
The Myo7ash1-8J mutation occurred spontaneously on B6,SJL-TgN(c177lacZ)226Bri while the latter was being bred in the Importation facility at The Jackson Laboratory. Myo7ash1-8J was transferred to the C57BL/6J background by seven rounds of backcross-intercross breeding; homozygous males produced by mating heterozygous sibs were bred to C57BL/6J females to yield the next generation of heterozygotes. The colony was genotyped for TgN(c177lacZ)226Bri in March, 2000 and verified free of the transgene.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Myo7ash1-8J | ||
|---|---|---|---|
| Allele Name | shaker 1, 8 Jackson | ||
| Strain of Origin | B6;SJL-Tg(c177-lacZ)226Bri/J | ||
| Gene Symbol and Name | Myo7a, myosin VIIa | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | DFNA11; DFNB2; MYOVIIA; MYU7A; Myo7; NSRD2; USH1B; myosin VII; neuroscience mutagenesis facility, 371; nmf371; sh-1; sh1; shaker 1; | ||
| General Note |
Genetic Background:The 266Bri stock on which Myo7ash1-8J arose was homozygous for a lacZ transgene. The mutation was not the result of the transgene integration, as not all animals exhibited the neurological phenotype. | ||
| Molecular Note | This phenotypic mutant was shown to be an allelic to Myo7ash1 by complementation testing. [MGI Ref ID J:77937] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Myo7ash1-8J | Heterozygote from the colony | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Myo7a
005468 C57BL/6J-Myo7ash1-11J/J 000619 FS/EiJ 000271 SH1/LeJ 002919 STOCK Myo7ash1-7J/J View Strains carrying other alleles of Myo7a (4 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Myo7ash1-8J related
Mouse/Human Gene Homologs
Usher syndrome, type IB (deafness, neurosensory, autosomal recessive, 2, and deafness, autosomal dominant nonsyndromic sensorineural, 11)
Neurobiology Research
Tremor Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.Cg-Myo7ash1-8J/J |
| Stock Number: | 003184 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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