Strain Name:

129/Sv-Lyntm1Sor/J

Stock Number:

003204

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Philippe Soriano,   Mount Sinai School of Medicine

Appearance
white-bellied agouti
Related Genotype: Aw/Aw

Description
Mice homozygous for the Lyntm1Sor targeted mutation are viable and fertile. However, age-related autoimmunity has been observed in homozygotes which may make it preferable to maintain the strain heterozygously, at least on a 129 background. Lyn-deficient mice are useful in analyzing the role of Lyn in B cell antigen receptor (BCR) signaling. Mutant mice have a reduced number of peripheral B cells with a greater proportion of immature cells and a higher than normal turnover rate. Aged homozygotes develop splenomegaly, produce autoantibodies, and have an expanded population of B lymphoblasts of the B1 lineage. Splenic B cells from young homozygotes initiate early BCR signaling events, although in a delayed fashion. B cells exhibit an enhanced MAP kinase activation and an increased proliferative response to BCR engagement.

Control Information

  Control
   Wild-type from the colony
   002448 129S1/SvImJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lyntm1Sor allele
003515   B6.129S4-Lyntm1Sor/J
View Strains carrying   Lyntm1Sor     (1 strain)

Additional Web Information

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Lyntm1Sor/Lyntm1Sor

        involves: 129S4/SvJae
  • immune system phenotype
  • decreased B cell number
    • mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice   (MGI Ref ID J:42037)
    • peripheral B cell numbers are reduced by 50% to 70% of wild-type   (MGI Ref ID J:42037)
    • B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments   (MGI Ref ID J:42037)
    • decreased mature B cell number   (MGI Ref ID J:42037)
  • enlarged lymph nodes
    • at 14 weeks of age, splenomegaly is often accompanied by enlargments of the lymph nodes with lymphoblasts and plasma cells   (MGI Ref ID J:42037)
    • blast cells within the lymph node are activated and have a B1 identity   (MGI Ref ID J:42037)
  • enlarged spleen
    • at 14 weeks of age   (MGI Ref ID J:42037)
  • increased B cell proliferation
    • B cell proliferation is more sensitive to anti-IgM than wild-type B cells   (MGI Ref ID J:42037)
  • increased anti-double stranded DNA antibody level
    • mice develop anti-dsDNA antibodies around 16 weeks of age unlike wild-type mice   (MGI Ref ID J:42037)
  • hematopoietic system phenotype
  • decreased B cell number
    • mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice   (MGI Ref ID J:42037)
    • peripheral B cell numbers are reduced by 50% to 70% of wild-type   (MGI Ref ID J:42037)
    • B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments   (MGI Ref ID J:42037)
    • decreased mature B cell number   (MGI Ref ID J:42037)
  • enlarged spleen
    • at 14 weeks of age   (MGI Ref ID J:42037)
  • increased B cell proliferation
    • B cell proliferation is more sensitive to anti-IgM than wild-type B cells   (MGI Ref ID J:42037)

Lyntm1Sor/Lyntm1Sor

        involves: 129S4/SvJaeSor
  • immune system phenotype
  • abnormal chemokine level
    • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice   (MGI Ref ID J:80658)
    • however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal   (MGI Ref ID J:80658)
    • abnormal circulating chemokine level
      • increased levels of a number of chemokines at 6 months of age   (MGI Ref ID J:200745)
  • abnormal circulating cytokine level
    • increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age   (MGI Ref ID J:200745)
    • high levels of circulating B-cell activating factor   (MGI Ref ID J:200745)
    • abnormal circulating chemokine level
      • increased levels of a number of chemokines at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interferon-gamma level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-12 level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-17 level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-6 level
      • at 6 months of age   (MGI Ref ID J:200745)
  • abnormal dendritic cell physiology
    • splenic dendritic cells produce more proinflammatory cytokines and more chemokines   (MGI Ref ID J:200745)
    • CD11chi DCs are hyperresponsive to cytokine stimulation   (MGI Ref ID J:200745)
  • abnormal macrophage physiology
    • fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells   (MGI Ref ID J:80658)
    • however, response to zymosan and macrophage recruitment are normal   (MGI Ref ID J:80658)
    • abnormal microglial cell physiology
      • fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice   (MGI Ref ID J:80658)
  • decreased B cell number   (MGI Ref ID J:200745)
    • decreased mature B cell number
      • peripheral B cell numbers are reduced by almost 10-fold   (MGI Ref ID J:146161)
      • decreased follicular B cell number
        • reduced by about 10-fold in the spleen   (MGI Ref ID J:146161)
      • decreased marginal zone B cell number
        • reduced numbers in the spleen   (MGI Ref ID J:146161)
    • decreased transitional stage B cell number
      • reduced numbers of T1 and T2 B cells are found in the spleen   (MGI Ref ID J:146161)
  • glomerulonephritis
    • mice develop severe glomerulonephritis around 8 months of age   (MGI Ref ID J:146161)
    • disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli   (MGI Ref ID J:146161)
    • glomerulonephritis without interstitial inflammation is seen by 8-10 months of age   (MGI Ref ID J:200745)
  • increased B cell proliferation
    • B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS   (MGI Ref ID J:146161)
  • increased IgA level
    • mice have elevated levels of IgA in sera   (MGI Ref ID J:146161)
  • increased IgM level
    • mice have elevated levels of IgM in sera   (MGI Ref ID J:146161)
  • increased autoantibody level
    • high levels of autoreactive antibodies in the serum   (MGI Ref ID J:200745)
    • increased anti-double stranded DNA antibody level
      • serum levels of anti-dsDNA antibodies increase with age with high levels occurring by 12 months of age   (MGI Ref ID J:146161)
      • levels of anti-dsDNA antibodies are below those of age-matched Lyn null homozygotes   (MGI Ref ID J:146161)
  • increased plasma cell number
    • increase in the number of CD19lo/- CD138hi plasma cells in the spleen   (MGI Ref ID J:200745)
  • liver inflammation
    • IgG depositions in the liver occur in older mice though no associated pathology is observed   (MGI Ref ID J:146161)
  • myeloid hyperplasia   (MGI Ref ID J:146161)
  • spleen hyperplasia
    • mice develop splenomegaly with age due to myeloid hyperplasia   (MGI Ref ID J:146161)
  • nervous system phenotype
  • abnormal microglial cell physiology
    • fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice   (MGI Ref ID J:80658)
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • deposition of C3 in the glomeruli   (MGI Ref ID J:200745)
    • glomerulonephritis
      • mice develop severe glomerulonephritis around 8 months of age   (MGI Ref ID J:146161)
      • disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli   (MGI Ref ID J:146161)
      • glomerulonephritis without interstitial inflammation is seen by 8-10 months of age   (MGI Ref ID J:200745)
    • glomerulosclerosis   (MGI Ref ID J:146161)
    • mesangial cell interposition
      • mesangial interposition in peripheral capillary loops   (MGI Ref ID J:146161)
    • renal glomerulus hypertrophy
      • enlarged glomeruli   (MGI Ref ID J:146161)
  • liver/biliary system phenotype
  • liver inflammation
    • IgG depositions in the liver occur in older mice though no associated pathology is observed   (MGI Ref ID J:146161)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells   (MGI Ref ID J:80658)
    • however, response to zymosan and macrophage recruitment are normal   (MGI Ref ID J:80658)
    • abnormal microglial cell physiology
      • fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice   (MGI Ref ID J:80658)
  • abnormal proerythroblast morphology
    • the ratio of Kit+ to Kit- proerythroblasts is increased compared to in wild-type mice   (MGI Ref ID J:146561)
  • decreased B cell number   (MGI Ref ID J:200745)
    • decreased mature B cell number
      • peripheral B cell numbers are reduced by almost 10-fold   (MGI Ref ID J:146161)
      • decreased follicular B cell number
        • reduced by about 10-fold in the spleen   (MGI Ref ID J:146161)
      • decreased marginal zone B cell number
        • reduced numbers in the spleen   (MGI Ref ID J:146161)
    • decreased transitional stage B cell number
      • reduced numbers of T1 and T2 B cells are found in the spleen   (MGI Ref ID J:146161)
  • increased B cell proliferation
    • B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS   (MGI Ref ID J:146161)
  • increased IgA level
    • mice have elevated levels of IgA in sera   (MGI Ref ID J:146161)
  • increased IgM level
    • mice have elevated levels of IgM in sera   (MGI Ref ID J:146161)
  • increased erythroid progenitor cell number
    • mice exhibit an accumulation of erythroid progenitor cells in the Kit+CD71high compartment compared to in wild-type mice   (MGI Ref ID J:146561)
  • increased plasma cell number
    • increase in the number of CD19lo/- CD138hi plasma cells in the spleen   (MGI Ref ID J:200745)
  • myeloid hyperplasia   (MGI Ref ID J:146161)
  • spleen hyperplasia
    • mice develop splenomegaly with age due to myeloid hyperplasia   (MGI Ref ID J:146161)
  • homeostasis/metabolism phenotype
  • abnormal chemokine level
    • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice   (MGI Ref ID J:80658)
    • however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal   (MGI Ref ID J:80658)
    • abnormal circulating chemokine level
      • increased levels of a number of chemokines at 6 months of age   (MGI Ref ID J:200745)
  • abnormal circulating cytokine level
    • increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age   (MGI Ref ID J:200745)
    • high levels of circulating B-cell activating factor   (MGI Ref ID J:200745)
    • abnormal circulating chemokine level
      • increased levels of a number of chemokines at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interferon-gamma level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-12 level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-17 level
      • at 6 months of age   (MGI Ref ID J:200745)
    • increased circulating interleukin-6 level
      • at 6 months of age   (MGI Ref ID J:200745)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lyntm1Sor/Lyntm1Sor

        B6.129S4-Lyntm1Sor
  • immune system phenotype
  • abnormal inflammatory response
    • following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit a modest reduction in hemorrhages compared to the thrombohemorrhagic vasculitis observed in wild-type mice   (MGI Ref ID J:113463)

Lyntm1Sor/Lyntm1Sor

        involves: 129S4/SvJaeSor * C57BL/6
  • immune system phenotype
  • decreased B cell number
    • bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice   (MGI Ref ID J:71174)
    • circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice   (MGI Ref ID J:71174)
    • decreased mature B cell number   (MGI Ref ID J:71174)
      • decreased B-1 B cell number   (MGI Ref ID J:71174)
  • enlarged spleen   (MGI Ref ID J:71174)
  • glomerulonephritis   (MGI Ref ID J:71174)
  • increased B cell proliferation
    • in response to BCR ligation   (MGI Ref ID J:71174)
    • however, B cell proliferation in response to LPS stimulation is normal   (MGI Ref ID J:71174)
  • increased IgA level   (MGI Ref ID J:71174)
  • increased IgG level
    • in the serum and kidney deposits   (MGI Ref ID J:71174)
    • increased IgG1 level   (MGI Ref ID J:71174)
    • increased IgG2b level   (MGI Ref ID J:71174)
  • increased IgM level   (MGI Ref ID J:71174)
  • increased anti-double stranded DNA antibody level   (MGI Ref ID J:71174)
  • increased susceptibility to systemic lupus erythematosus   (MGI Ref ID J:71174)
  • renal/urinary system phenotype
  • glomerulonephritis   (MGI Ref ID J:71174)
  • hematopoietic system phenotype
  • decreased B cell number
    • bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice   (MGI Ref ID J:71174)
    • circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice   (MGI Ref ID J:71174)
    • decreased mature B cell number   (MGI Ref ID J:71174)
      • decreased B-1 B cell number   (MGI Ref ID J:71174)
  • enlarged spleen   (MGI Ref ID J:71174)
  • increased B cell proliferation
    • in response to BCR ligation   (MGI Ref ID J:71174)
    • however, B cell proliferation in response to LPS stimulation is normal   (MGI Ref ID J:71174)
  • increased IgA level   (MGI Ref ID J:71174)
  • increased IgG level
    • in the serum and kidney deposits   (MGI Ref ID J:71174)
    • increased IgG1 level   (MGI Ref ID J:71174)
    • increased IgG2b level   (MGI Ref ID J:71174)
  • increased IgM level   (MGI Ref ID J:71174)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lyntm1Sor related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Immunodeficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lyntm1Sor
Allele Name targeted mutation 1, Philippe Soriano
Allele Type Targeted (Null/Knockout)
Common Name(s) Lyn-;
Mutation Made ByDr. Philippe Soriano,   Mount Sinai School of Medicine
Strain of Origin129S4/SvJaeSor
ES Cell Line NameAK7
ES Cell Line Strain129S4/SvJaeSor
Gene Symbol and Name Lyn, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Chromosome 4
Gene Common Name(s) AA407514; Hck-2; JTK8; expressed sequence AA407514; hemopoietic cell kinase 2; p53Lyn; p56Lyn;
Molecular Note A neomycin resistance cassette replaced exons 3 - 7 of the gene. No transcript for the targeted gene was detected on Northern blots from homozygous mutant mouse bone marrow cells. [MGI Ref ID J:102647] [MGI Ref ID J:42037]

Genotyping

Genotyping Information

Genotyping Protocols

Lyntm1Sor, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Chan VW; Meng F; Soriano P; DeFranco AL; Lowell CA. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7(1):69-81. [PubMed: 9252121]  [MGI Ref ID J:42037]

Additional References

Lyntm1Sor related

Agosti V; Karur V; Sathyanarayana P; Besmer P; Wojchowski DM. 2009. A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol 37(2):159-71. [PubMed: 19100679]  [MGI Ref ID J:146561]

Allman D; Lindsley RC; DeMuth W; Rudd K; Shinton SA; Hardy RR. 2001. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 167(12):6834-40. [PubMed: 11739500]  [MGI Ref ID J:112116]

Barouch-Bentov R; Che J; Lee CC; Yang Y; Herman A; Jia Y; Velentza A; Watson J; Sternberg L; Kim S; Ziaee N; Miller A; Jackson C; Fujimoto M; Young M; Batalov S; Liu Y; Warmuth M; Wiltshire T; Cooke MP; Sauer K. 2009. A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Mol Cell 33(1):43-52. [PubMed: 19150426]  [MGI Ref ID J:146161]

Borneo J; Munugalavadla V; Sims EC; Vemula S; Orschell CM; Yoder M; Kapur R. 2007. Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors. Exp Hematol 35(7):1026-37. [PubMed: 17588471]  [MGI Ref ID J:123081]

Cai H; Smith DA; Memarzadeh S; Lowell CA; Cooper JA; Witte ON. 2011. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A 108(16):6579-84. [PubMed: 21464326]  [MGI Ref ID J:171364]

Cain JA; Xiang Z; O'Neal J; Kreisel F; Colson A; Luo H; Hennighausen L; Tomasson MH. 2007. Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage. Blood 109(9):3906-14. [PubMed: 17218386]  [MGI Ref ID J:145325]

Chan VW; Lowell CA; DeFranco AL. 1998. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol 8(10):545-53. [PubMed: 9601638]  [MGI Ref ID J:146423]

Chan VW; Mecklenbrauker I; Su I; Texido G; Leitges M; Carsetti R; Lowell CA; Rajewsky K; Miyake K; Tarakhovsky A. 1998. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med 188(1):93-101. [PubMed: 9653087]  [MGI Ref ID J:115145]

Chari R; Kim S; Murugappan S; Sanjay A; Daniel JL; Kunapuli SP. 2009. Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood 114(14):3056-63. [PubMed: 19587372]  [MGI Ref ID J:153266]

Cho MJ; Pestina TI; Steward SA; Lowell CA; Jackson CW; Gartner TK. 2002. Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. Blood 99(7):2442-7. [PubMed: 11895777]  [MGI Ref ID J:115368]

Chu CL; Lowell CA. 2005. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol 175(5):2880-9. [PubMed: 16116174]  [MGI Ref ID J:113243]

Contreras CM; Halcomb KE; Randle L; Hinman RM; Gutierrez T; Clarke SH; Satterthwaite AB. 2007. Btk regulates multiple stages in the development and survival of B-1 cells. Mol Immunol 44(10):2719-28. [PubMed: 17207856]  [MGI Ref ID J:118704]

Crowley MT; Costello PS; Fitzer-Attas CJ; Turner M; Meng F; Lowell C; Tybulewicz VL; DeFranco AL. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med 186(7):1027-39. [PubMed: 9314552]  [MGI Ref ID J:78301]

Du C; Sriram S. 2002. Increased Severity of Experimental Allergic Encephalomyelitis in lyn(-/-) Mice in the Absence of Elevated Proinflammatory Cytokine Response in the Central Nervous System. J Immunol 168(6):3105-12. [PubMed: 11884485]  [MGI Ref ID J:75323]

Evangelista V; Pamuklar Z; Piccoli A; Manarini S; Dell'elba G; Pecce R; Martelli N; Federico L; Rojas M; Berton G; Lowell CA; Totani L; Smyth SS. 2007. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood 109(6):2461-9. [PubMed: 17095622]  [MGI Ref ID J:145358]

Falanga YT; Chaimowitz NS; Charles N; Finkelman FD; Pullen NA; Barbour S; Dholaria K; Faber T; Kolawole M; Huang B; Odom S; Rivera J; Carlyon J; Conrad DH; Spiegel S; Oskeritzian CA; Ryan JJ. 2012. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol 188(9):4360-8. [PubMed: 22450804]  [MGI Ref ID J:188465]

Fitzer-Attas CJ; Lowry M; Crowley MT; Finn AJ; Meng F; DeFranco AL; Lowell CA. 2000. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med 191(4):669-81. [PubMed: 10684859]  [MGI Ref ID J:78302]

Frossi B; Rivera J; Hirsch E; Pucillo C. 2007. Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol 178(4):2549-55. [PubMed: 17277164]  [MGI Ref ID J:143971]

Fumagalli L; Campa CC; Germena G; Lowell CA; Hirsch E; Berton G. 2013. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol 190(7):3648-60. [PubMed: 23447687]  [MGI Ref ID J:194836]

Goldenberg-Furmanov M; Stein I; Pikarsky E; Rubin H; Kasem S; Wygoda M; Weinstein I; Reuveni H; Ben-Sasson SA. 2004. Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts. Cancer Res 64(3):1058-66. [PubMed: 14871838]  [MGI Ref ID J:88436]

Gomez G; Gonzalez-Espinosa C; Odom S; Baez G; Cid ME; Ryan JJ; Rivera J. 2005. Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol 175(11):7602-10. [PubMed: 16301670]  [MGI Ref ID J:122154]

Grewal PK; Boton M; Ramirez K; Collins BE; Saito A; Green RS; Ohtsubo K; Chui D; Marth JD. 2006. ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling. Mol Cell Biol 26(13):4970-81. [PubMed: 16782884]  [MGI Ref ID J:110325]

Gross AJ; Lyandres JR; Panigrahi AK; Prak ET; DeFranco AL. 2009. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol 182(9):5382-92. [PubMed: 19380785]  [MGI Ref ID J:150309]

Gross AJ; Proekt I; DeFranco AL. 2011. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol 41(12):3645-55. [PubMed: 21928281]  [MGI Ref ID J:179511]

Guo B; Blair D; Chiles TC; Lowell CA; Rothstein TL. 2007. Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol 178(8):4726-30. [PubMed: 17404251]  [MGI Ref ID J:145207]

Guo B; Rothstein TL. 2013. A novel Lyn-protein kinase Cdelta/epsilon-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling. Eur J Immunol 43(6):1643-50. [PubMed: 23457006]  [MGI Ref ID J:198141]

Guo B; Rothstein TL. 2013. IL-4 upregulates Igalpha and Igbeta protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation. J Immunol 191(2):670-7. [PubMed: 23776171]  [MGI Ref ID J:205452]

Gutierrez T; Halcomb KE; Coughran AJ; Li QZ; Satterthwaite AB. 2010. Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice. Eur J Immunol 40(7):1897-905. [PubMed: 20394076]  [MGI Ref ID J:165938]

Gutierrez T; Mayeux JM; Ortega SB; Karandikar NJ; Li QZ; Rakheja D; Zhou XJ; Satterthwaite AB. 2013. IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn(-/-) mice. Eur J Immunol 43(2):382-93. [PubMed: 23169140]  [MGI Ref ID J:192815]

Han J; Zhang G; Welch EJ; Liang Y; Fu J; Vogel SM; Lowell CA; Du X; Cheresh DA; Malik AB; Li Z. 2013. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood 122(25):4140-9. [PubMed: 24108461]  [MGI Ref ID J:206479]

Hasegawa M; Fujimoto M; Poe JC; Steeber DA; Lowell CA; Tedder TF. 2001. A cd19-dependent signaling pathway regulates autoimmunity in lyn-deficient mice. J Immunol 167(5):2469-78. [PubMed: 11509585]  [MGI Ref ID J:71174]

Hernandez-Hansen V; Mackay GA; Lowell CA; Wilson BS; Oliver JM. 2004. The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 75(1):143-51. [PubMed: 14525964]  [MGI Ref ID J:87475]

Hernandez-Hansen V; Smith AJ; Surviladze Z; Chigaev A; Mazel T; Kalesnikoff J; Lowell CA; Krystal G; Sklar LA; Wilson BS; Oliver JM. 2004. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 173(1):100-12. [PubMed: 15210764]  [MGI Ref ID J:90928]

Hirahashi J; Mekala D; Van Ziffle J; Xiao L; Saffaripour S; Wagner DD; Shapiro SD; Lowell C; Mayadas TN. 2006. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 25(2):271-83. [PubMed: 16872848]  [MGI Ref ID J:113463]

Hong H; Kitaura J; Xiao W; Horejsi V; Ra C; Lowell CA; Kawakami Y; Kawakami T. 2007. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 110(7):2511-9. [PubMed: 17513616]  [MGI Ref ID J:147024]

Hua Z; Gross AJ; Lamagna C; Ramos-Hernandez N; Scapini P; Ji M; Shao H; Lowell CA; Hou B; DeFranco AL. 2014. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol 192(3):875-85. [PubMed: 24379120]  [MGI Ref ID J:207303]

Iwaki S; Tkaczyk C; Satterthwaite AB; Halcomb K; Beaven MA; Metcalfe DD; Gilfillan AM. 2005. Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit. J Biol Chem 280(48):40261-70. [PubMed: 16176929]  [MGI Ref ID J:132405]

Jakus Z; Simon E; Frommhold D; Sperandio M; Mocsai A. 2009. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med 206(3):577-93. [PubMed: 19273622]  [MGI Ref ID J:147080]

Kannan S; Huang H; Seeger D; Audet A; Chen Y; Huang C; Gao H; Li S; Wu M. 2009. Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS ONE 4(3):e4891. [PubMed: 19305493]  [MGI Ref ID J:147465]

Karur VG; Lowell CA; Besmer P; Agosti V; Wojchowski DM. 2006. Lyn kinase promotes erythroblast expansion and late-stage development. Blood 108(5):1524-32. [PubMed: 16705093]  [MGI Ref ID J:138064]

Kawakami Y; Kitaura J; Hartman SE; Lowell CA; Siraganian RP; Kawakami T. 2000. Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A 97(13):7423-8. [PubMed: 10852954]  [MGI Ref ID J:126402]

Kawakami Y; Kitaura J; Satterthwaite AB; Kato RM; Asai K; Hartman SE; Maeda-Yamamoto M; Lowell CA; Rawlings DJ; Witte ON; Kawakami T. 2000. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol 165(3):1210-9. [PubMed: 10903718]  [MGI Ref ID J:120482]

Kennedy DJ; Kuchibhotla S; Westfall KM; Silverstein RL; Morton RE; Febbraio M. 2011. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res 89(3):604-13. [PubMed: 21088116]  [MGI Ref ID J:186882]

Kim S; Kunapuli SP. 2011. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. J Biol Chem 286(27):24170-9. [PubMed: 21592972]  [MGI Ref ID J:174988]

Lamagna C; Hu Y; DeFranco AL; Lowell CA. 2014. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol 192(3):919-28. [PubMed: 24376269]  [MGI Ref ID J:207305]

Lamagna C; Scapini P; van Ziffle JA; Defranco AL; Lowell CA. 2013. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A 110(35):E3311-20. [PubMed: 23940344]  [MGI Ref ID J:200745]

Lannutti BJ; Minear J; Blake N; Drachman JG. 2006. Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 25(23):3316-24. [PubMed: 16418722]  [MGI Ref ID J:144143]

Lee JY; Lowell CA; Lemay DG; Youn HS; Rhee SH; Sohn KH; Jang B; Ye J; Chung JH; Hwang DH. 2005. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol 70(8):1231-40. [PubMed: 16140274]  [MGI Ref ID J:102647]

Lee LJ; Lo FS; Erzurumlu RS. 2005. NMDA receptor-dependent regulation of axonal and dendritic branching. J Neurosci 25(9):2304-11. [PubMed: 15745956]  [MGI Ref ID J:98614]

Li G; Fox J 3rd; Liu Z; Liu J; Gao GF; Jin Y; Gao H; Wu M. 2013. Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models. J Immunol 191(11):5359-70. [PubMed: 24127553]  [MGI Ref ID J:207032]

Li X; Zhou X; Ye Y; Li Y; Li J; Privratsky B; Wu E; Gao H; Huang C; Wu M. 2014. Lyn regulates inflammatory responses in Klebsiella pneumoniae infection via the p38/NF-kappaB pathway. Eur J Immunol 44(3):763-73. [PubMed: 24338528]  [MGI Ref ID J:209291]

Li Z; Zhang G; Liu J; Stojanovic A; Ruan C; Lowell CA; Du X. 2010. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem 285(17):12559-70. [PubMed: 20189992]  [MGI Ref ID J:178438]

Liu J; Fitzgerald ME; Berndt MC; Jackson CW; Gartner TK. 2006. Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood 108(8):2596-603. [PubMed: 16788103]  [MGI Ref ID J:139466]

Liu J; Pestina TI; Berndt MC; Jackson CW; Gartner TK. 2005. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood 106(8):2750-6. [PubMed: 15985541]  [MGI Ref ID J:119538]

Lovewell RR; Hayes SM; O'Toole GA; Berwin B. 2014. Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment. Am J Physiol Lung Cell Mol Physiol 306(7):L698-707. [PubMed: 24487390]  [MGI Ref ID J:210183]

Majeed M; Caveggion E; Lowell CA; Berton G. 2001. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol 70(5):801-11. [PubMed: 11698501]  [MGI Ref ID J:124460]

Meng F; Lowell CA. 1998. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J 17(15):4391-403. [PubMed: 9687507]  [MGI Ref ID J:114192]

Meng F; Lowell CA. 1997. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 185(9):1661-70. [PubMed: 9151903]  [MGI Ref ID J:78300]

Mermel CH; McLemore ML; Liu F; Pereira S; Woloszynek J; Lowell CA; Link DC. 2006. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood 108(8):2562-8. [PubMed: 16772601]  [MGI Ref ID J:139473]

Ming Z; Hu Y; Xiang J; Polewski P; Newman PJ; Newman DK. 2011. Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood 117(14):3903-6. [PubMed: 21297004]  [MGI Ref ID J:172845]

Mocsai A; Abram CL; Jakus Z; Hu Y; Lanier LL; Lowell CA. 2006. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7(12):1326-33. [PubMed: 17086186]  [MGI Ref ID J:116120]

Moore KJ; El Khoury J; Medeiros LA; Terada K; Geula C; Luster AD; Freeman MW. 2002. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem 277(49):47373-9. [PubMed: 12239221]  [MGI Ref ID J:80658]

Murphy AJ; Bijl N; Yvan-Charvet L; Welch CB; Bhagwat N; Reheman A; Wang Y; Shaw JA; Levine RL; Ni H; Tall AR; Wang N. 2013. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med 19(5):586-94. [PubMed: 23584088]  [MGI Ref ID J:198517]

Nelson MP; Christmann BS; Werner JL; Metz AE; Trevor JL; Lowell CA; Steele C. 2011. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol 186(4):2372-81. [PubMed: 21220696]  [MGI Ref ID J:169168]

Nelson MP; Metz AE; Li S; Lowell CA; Steele C. 2009. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun 77(5):1790-7. [PubMed: 19255189]  [MGI Ref ID J:148185]

Nunomura S; Gon Y; Yoshimaru T; Kashiwakura J; Kawakami T; Ra C. 2010. FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors. Eur J Immunol 40(4):1205-17. [PubMed: 20101614]  [MGI Ref ID J:159195]

O'Laughlin-Bunner B; Radosevic N; Taylor ML; Shivakrupa; DeBerry C; Metcalfe DD; Zhou M; Lowell C; Linnekin D. 2001. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 98(2):343-50. [PubMed: 11435302]  [MGI Ref ID J:70417]

Orschell CM; Borneo J; Munugalavadla V; Ma P; Sims E; Ramdas B; Yoder MC; Kapur R. 2008. Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Exp Hematol 36(5):655-66. [PubMed: 18346837]  [MGI Ref ID J:136094]

Parameswaran N; Enyindah-Asonye G; Bagheri N; Shah NB; Gupta N. 2013. Spatial Coupling of JNK Activation to the B Cell Antigen Receptor by Tyrosine-Phosphorylated Ezrin. J Immunol 190(5):2017-26. [PubMed: 23338238]  [MGI Ref ID J:193491]

Parravicini V; Gadina M; Kovarova M; Odom S; Gonzalez-Espinosa C; Furumoto Y; Saitoh S; Samelson LE; O'Shea JJ; Rivera J. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3(8):741-8. [PubMed: 12089510]  [MGI Ref ID J:109153]

Paul R; Obermaier B; Van Ziffle J; Angele B; Pfister HW; Lowell CA; Koedel U. 2008. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol 84(4):1141-50. [PubMed: 18625913]  [MGI Ref ID J:140230]

Peng C; Chen Y; Shan Y; Zhang H; Guo Z; Li D; Li S. 2012. LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells. PLoS One 7(6):e38614. [PubMed: 22675576]  [MGI Ref ID J:187845]

Pereira S; Zhou M; Mocsai A; Lowell C. 2001. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol 166(6):4115-23. [PubMed: 11238661]  [MGI Ref ID J:126135]

Poderycki M; Tomimori Y; Ando T; Xiao W; Maeda-Yamamoto M; Sauer K; Kawakami Y; Kawakami T. 2010. A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. J Immunol 184(1):84-93. [PubMed: 19949072]  [MGI Ref ID J:159041]

Ruschmann J; Ho V; Antignano F; Kuroda E; Lam V; Ibaraki M; Snyder K; Kim C; Flavell RA; Kawakami T; Sly L; Turhan AG; Krystal G. 2010. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Exp Hematol 38(5):392-402, 402.e1. [PubMed: 20304029]  [MGI Ref ID J:164034]

Satterthwaite AB; Lowell CA; Khan WN; Sideras P; Alt FW; Witte ON. 1998. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med 188(5):833-44. [PubMed: 9730885]  [MGI Ref ID J:50288]

Satterthwaite AB; Willis F; Kanchanastit P; Fruman D; Cantley LC; Helgason CD; Humphries RK; Lowell CA; Simon M; Leitges M; Tarakhovsky A; Tedder TF; Lesche R; Wu H; Witte ON. 2000. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A 97(12):6687-92. [PubMed: 10829070]  [MGI Ref ID J:62717]

Scapini P; Hu Y; Chu CL; Migone TS; Defranco AL; Cassatella MA; Lowell CA. 2010. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 207(8):1757-73. [PubMed: 20624892]  [MGI Ref ID J:163472]

Scapini P; Lamagna C; Hu Y; Lee K; Tang Q; Defranco AL; Lowell CA. 2011. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A 108(41):E823-32. [PubMed: 21911371]  [MGI Ref ID J:177380]

Schram BR; Tze LE; Ramsey LB; Liu J; Najera L; Vegoe AL; Hardy RR; Hippen KL; Farrar MA; Behrens TW. 2008. B cell receptor Basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunol 180(7):4728-41. [PubMed: 18354197]  [MGI Ref ID J:133383]

Seo Sj; Buckler J; Erikson J. 2001. Novel roles for lyn in b cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded dna ig transgenic mice. J Immunol 166(6):3710-6. [PubMed: 11238611]  [MGI Ref ID J:67891]

Severin S; Pollitt AY; Navarro-Nunez L; Nash CA; Mourao-Sa D; Eble JA; Senis YA; Watson SP. 2011. Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. J Biol Chem 286(6):4107-16. [PubMed: 21098033]  [MGI Ref ID J:169492]

Shahaf G; Gross AJ; Sternberg-Simon M; Kaplan D; Defranco AL; Mehr R. 2012. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol 42(2):511-21. [PubMed: 22057631]  [MGI Ref ID J:179824]

Shao B; Wahrenbrock MG; Yao L; David T; Coughlin SR; Xia L; Varki A; McEver RP. 2011. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood 118(15):4015-23. [PubMed: 21860019]  [MGI Ref ID J:178397]

Shao B; Yago T; Coghill PA; Klopocki AG; Mehta-D'souza P; Schmidtke DW; Rodgers W; McEver RP. 2012. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin alphaLbeta2. J Biol Chem 287(23):19585-98. [PubMed: 22511754]  [MGI Ref ID J:186204]

Shih TA; Roederer M; Nussenzweig MC. 2002. Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol 3(4):399-406. [PubMed: 11896394]  [MGI Ref ID J:75653]

Shimomura Y; Ogawa A; Kawada M; Sugimoto K; Mizoguchi E; Shi HN; Pillai S; Bhan AK; Mizoguchi A. 2008. A unique B2 B cell subset in the intestine. J Exp Med 205(6):1343-55. [PubMed: 18519649]  [MGI Ref ID J:137039]

Sperber BR; Boyle-Walsh EA; Engleka MJ; Gadue P; Peterson AC; Stein PL; Scherer SS; McMorris FA. 2001. A unique role for Fyn in CNS myelination. J Neurosci 21(6):2039-47. [PubMed: 11245687]  [MGI Ref ID J:109485]

Subramanian A; Hegde S; Correll PH; Paulson RF. 2006. Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility. Leuk Res 30(9):1141-9. [PubMed: 16527351]  [MGI Ref ID J:112835]

Whyburn LR; Halcomb KE; Contreras CM; Lowell CA; Witte ON; Satterthwaite AB. 2003. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol 171(4):1850-8. [PubMed: 12902486]  [MGI Ref ID J:84810]

Xiao W; Ando T; Wang HY; Kawakami Y; Kawakami T. 2010. Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Blood 116(26):6003-13. [PubMed: 20858858]  [MGI Ref ID J:167395]

Xiao W; Hong H; Kawakami Y; Lowell CA; Kawakami T. 2008. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest 118(3):924-34. [PubMed: 18246197]  [MGI Ref ID J:135267]

Xiao W; Kashiwakura J; Hong H; Yasudo H; Ando T; Maeda-Yamamoto M; Wu D; Kawakami Y; Kawakami T. 2011. Phospholipase C-beta3 Regulates FcvarepsilonRI-Mediated Mast Cell Activation by Recruiting the Protein Phosphatase SHP-1. Immunity 34(6):893-904. [PubMed: 21683628]  [MGI Ref ID J:174006]

Xiao W; Nishimoto H; Hong H; Kitaura J; Nunomura S; Maeda-Yamamoto M; Kawakami Y; Lowell CA; Ra C; Kawakami T. 2005. Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol 175(10):6885-92. [PubMed: 16272347]  [MGI Ref ID J:119693]

Yago T; Shao B; Miner JJ; Yao L; Klopocki AG; Maeda K; Coggeshall KM; McEver RP. 2010. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood 116(3):485-94. [PubMed: 20299514]  [MGI Ref ID J:162825]

Yin H; Liu J; Li Z; Berndt MC; Lowell CA; Du X. 2008. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood 112(4):1139-46. [PubMed: 18550847]  [MGI Ref ID J:139181]

Yu CC; Yen TS; Lowell CA; DeFranco AL. 2001. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol 11(1):34-8. [PubMed: 11166177]  [MGI Ref ID J:95660]

Zarbock A; Abram CL; Hundt M; Altman A; Lowell CA; Ley K. 2008. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med 205(10):2339-47. [PubMed: 18794338]  [MGI Ref ID J:140111]

Zhu M; Liu Y; Koonpaew S; Granillo O; Zhang W. 2004. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med 200(8):991-1000. [PubMed: 15477350]  [MGI Ref ID J:93951]

Zhu Z; Li R; Li H; Zhou T; Davis RS. 2013. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci U S A 110(14):E1282-90. [PubMed: 23509253]  [MGI Ref ID J:194234]

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

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Cryorecovery* $2525.00
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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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