Strain Name:

D2.129P2(B6)-Nr5a1tm1Klp/EiJ

Stock Number:

003219

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names D2.129P2(B6)-Nr5a1tm1Klp    (Changed: 05-APR-07 )
Ftzf1    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain DBA/2J
Donor Strain B6;129P-Ftzf1tm1Klp (129P2 derived E14TG2a ES cell line)
 
Donating InvestigatorDr. Keith L. Parker,   Univ Texas Southwestern Medical Center

Appearance
dilute brown
Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad

Description
Mice homozygous for the Nr5a1tm1Klp (formerly Ftzf1tm1Klp) targeted mutation exhibit adrenal and gonadal agenesis. There is also an absence of the ventromedial hypothalamic nucleus leading to impaired expression of gonadotrope specific markers.

Control Information

  Control
   Heterozygote from the colony
   See control note: Wildtype mice from the colony or DBA/2J mice (Stock No. 000671) may be used as controls.
   000671 DBA/2J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Nr5a1
007041   B6Ei.129P2-Nr5a1tm2Klp/EiJ
007042   D2.129P2(B6)-Nr5a1tm2Klp/EiJ
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
View Strains carrying other alleles of Nr5a1     (4 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
46,xy Sex Reversal 3; SRXY3   (NR5A1)
Nuclear Receptor Subfamily 5, Group A, Member 1; NR5A1   (NR5A1)
Premature Ovarian Failure 7; POF7   (NR5A1)
Spermatogenic Failure 8; SPGF8   (NR5A1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Nr5a1tm1Klp/Nr5a1tm1Klp

        involves: 129P2/OlaHsd * C57BL/6 * DBA/2
  • mortality/aging
  • complete postnatal lethality
    • animals die within 8 days of birth due to adrenal insufficiency   (MGI Ref ID J:35576)
  • partial postnatal lethality
    • most untreated homozygotes die within 3 days of birth; one lived to 8 days of age; with daily corticosteroid treatment, 50% of null animals survive to weaning age   (MGI Ref ID J:28763)
  • premature death
    • 16% of homozygotes survive for more than a month with corticosteroid intervention   (MGI Ref ID J:28763)
  • endocrine/exocrine gland phenotype
  • absent adrenal gland
    • a consequence of apoptosis within the developing adrenal gland: apparent at E11.5   (MGI Ref ID J:35576)
  • agonadal
    • a consequence of apoptosis in both sexes: apparent in the genital ridge at E12   (MGI Ref ID J:35576)
    • absent ovary
      • females lacked ovaries   (MGI Ref ID J:35576)
    • absent testes
      • males lacked testes   (MGI Ref ID J:35576)
  • reproductive system phenotype
  • abnormal primary sex determination   (MGI Ref ID J:35576)
    • agonadal
      • a consequence of apoptosis in both sexes: apparent in the genital ridge at E12   (MGI Ref ID J:35576)
      • absent ovary
        • females lacked ovaries   (MGI Ref ID J:35576)
      • absent testes
        • males lacked testes   (MGI Ref ID J:35576)
  • secondary sex reversal
    • genotypic males develop uteri, vagina and oviducts: apparent at E12   (MGI Ref ID J:35576)
    • external genitalia of genotypic males are female   (MGI Ref ID J:35576)
  • embryogenesis phenotype
  • abnormal gonadal ridge morphology
    • apoptosis in both sexes: apparent in the genital ridge at E12   (MGI Ref ID J:35576)

Nr5a1tm1Klp/Nr5a1tm1Klp

        involves: 129P2/OlaHsd * C57BL/6 * FVB
  • nervous system phenotype
  • abnormal hypothalamus morphology
    • impaired terminal differentiation of ventromedial hypothalamic nucleus neurons   (MGI Ref ID J:83384)
  • abnormal innervation
    • neonates exhibit a loss of ventromedial hypothalamic nucleus projections to both the bed nucleus of stria terminalis and amygdala, but maintain limited projections to the anterior hypothalamus   (MGI Ref ID J:83384)
  • abnormal neuron differentiation
    • expression of early and late ventromedial hypothalamic nucleus markers is altered indicating impaired terminal differentiation of ventromedial hypothalamic nucleus neurons   (MGI Ref ID J:83384)
  • cellular phenotype
  • abnormal neuron differentiation
    • expression of early and late ventromedial hypothalamic nucleus markers is altered indicating impaired terminal differentiation of ventromedial hypothalamic nucleus neurons   (MGI Ref ID J:83384)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Nr5a1tm1Klp related

Developmental Biology Research
Neurodevelopmental Defects

Endocrine Deficiency Research
Hypothalamus/Pituitary Defects

Neurobiology Research
Neurodevelopmental Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
Endocrine Deficiencies Affecting Gonads
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Nr5a1tm1Klp
Allele Name targeted mutation 1, Keith L Parker
Allele Type Targeted (Null/Knockout)
Common Name(s) Ftz-F1; Ftz-F1-; Ftzf1tm1Klp; SF-1; Sf1-; Sf-; sf-1-;
Mutation Made ByDr. Keith Parker,   Univ Texas Southwestern Medical Center
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Nr5a1, nuclear receptor subfamily 5, group A, member 1
Chromosome 2
Gene Common Name(s) AD4BP; Ad4BP/SF-1; ELP; FTZ1; FTZF1; Ftz-F1; Ftzf1; POF7; SF-1; SF1; SPGF8; SRXY3; adrenal 4-binding protein; fushi tarazu 1 factor homolog, (Drosophila); steroidogenic factor 1;
Molecular Note A neomycin cassette was inserted into exon 4, which disrupted sequences encoding the second zinc finger of the DNA binding domain. [MGI Ref ID J:35576]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Luo X; Ikeda Y; Parker KL. 1994. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77(4):481-90. [PubMed: 8187173]  [MGI Ref ID J:35576]

Additional References

Ingraham HA; Lala DS; Ikeda Y; Luo X; Shen WH; Nachtigal MW; Abbud R; Nilson JH; Parker KL. 1994. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 8(19):2302-12. [PubMed: 7958897]  [MGI Ref ID J:20830]

Nr5a1tm1Klp related

Babu PS; Bavers DL; Beuschlein F; Shah S; Jeffs B; Jameson JL; Hammer GD. 2002. Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Endocrinology 143(2):665-73. [PubMed: 11796523]  [MGI Ref ID J:74975]

Bland ML; Fowkes RC; Ingraham HA. 2004. Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol 18(4):941-52. [PubMed: 14726490]  [MGI Ref ID J:89122]

Bland ML; Jamieson CA; Akana SF; Bornstein SR; Eisenhofer G; Dallman MF; Ingraham HA. 2000. Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response Proc Natl Acad Sci U S A 97(26):14488-93. [PubMed: 11121051]  [MGI Ref ID J:66576]

Brennan J; Capel B. 2004. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 5(7):509-21. [PubMed: 15211353]  [MGI Ref ID J:90770]

Brown AE; Mani S; Tobet SA. 1999. The preoptic area/anterior hypothalamus of different strains of mice: sex differences and development. Brain Res Dev Brain Res 115(2):171-82. [PubMed: 10407134]  [MGI Ref ID J:56360]

Buaas FW; Val P; Swain A. 2009. The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet 18(16):2989-3001. [PubMed: 19457926]  [MGI Ref ID J:150743]

Budefeld T; Tobet SA; Majdic G. 2011. Altered position of cell bodies and fibers in the ventromedial region in SF-1 knockout mice. Exp Neurol 232(2):176-84. [PubMed: 21906594]  [MGI Ref ID J:178372]

Cao G; Zhao L; Stangl H; Hasegawa T; Richardson JA; Parker KL; Hobbs HH. 1999. Developmental and hormonal regulation of murine scavenger receptor, class B, type 1. Mol Endocrinol 13(9):1460-73. [PubMed: 10478838]  [MGI Ref ID J:57052]

Cooke HJ; Saunders PT. 2002. Mouse models of male infertility. Nat Rev Genet 3(10):790-801. [PubMed: 12360237]  [MGI Ref ID J:79958]

Correa SM; Washburn LL; Kahlon RS; Musson MC; Bouma GJ; Eicher EM; Albrecht KH. 2012. Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet 8(4):e1002569. [PubMed: 22496664]  [MGI Ref ID J:183829]

Davis AM; Seney ML; Stallings NR; Zhao L; Parker KL; Tobet SA. 2004. Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. J Neurobiol 60(4):424-36. [PubMed: 15307147]  [MGI Ref ID J:104979]

Dellovade TL; Young M; Ross EP; Henderson R; Caron K; Parker K; Tobet SA. 2000. Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes J Comp Neurol 423(4):579-89. [PubMed: 10880989]  [MGI Ref ID J:63148]

Gut P; Huber K; Lohr J; Bruhl B; Oberle S; Treier M; Ernsberger U; Kalcheim C; Unsicker K. 2005. Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells. Development 132(20):4611-9. [PubMed: 16176945]  [MGI Ref ID J:101728]

Ikeda Y; Luo X; Abbud R; Nilson JH; Parker KL. 1995. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 9(4):478-86. [PubMed: 7659091]  [MGI Ref ID J:112439]

Ingraham HA; Lala DS; Ikeda Y; Luo X; Shen WH; Nachtigal MW; Abbud R; Nilson JH; Parker KL. 1994. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 8(19):2302-12. [PubMed: 7958897]  [MGI Ref ID J:20830]

Jeyasuria P; Ikeda Y; Jamin SP; Zhao L; De Rooij DG; Themmen AP; Behringer RR; Parker KL. 2004. Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Mol Endocrinol 18(7):1610-9. [PubMed: 15118069]  [MGI Ref ID J:91352]

Karpova T; Presley J; Manimaran RR; Scherrer SP; Tejada L; Peterson KR; Heckert LL. 2005. A FTZ-F1-containing yeast artificial chromosome recapitulates expression of steroidogenic factor 1 in vivo. Mol Endocrinol 19(10):2549-63. [PubMed: 15961510]  [MGI Ref ID J:105635]

Keeney DS; Ikeda Y; Waterman MR; Parker KL. 1995. Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Mol Endocrinol 9(8):1091-8. [PubMed: 7476982]  [MGI Ref ID J:27992]

Kim KW; Jo YH; Zhao L; Stallings NR; Chua SC Jr; Parker KL. 2008. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol 22(8):1950-61. [PubMed: 18511494]  [MGI Ref ID J:138418]

Kim KW; Li S; Zhao H; Peng B; Tobet SA; Elmquist JK; Parker KL; Zhao L. 2010. CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function. Mol Endocrinol 24(6):1240-50. [PubMed: 20339005]  [MGI Ref ID J:162263]

Kim KW; Zhao L; Donato J Jr; Kohno D; Xu Y; Elias CF; Lee C; Parker KL; Elmquist JK. 2011. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 108(26):10673-8. [PubMed: 21636788]  [MGI Ref ID J:173306]

Knoll JG; Wolfe CA; Tobet SA. 2007. Estrogen modulates neuronal movements within the developing preoptic area-anterior hypothalamus. Eur J Neurosci 26(5):1091-9. [PubMed: 17767488]  [MGI Ref ID J:127257]

Kurrasch DM; Cheung CC; Lee FY; Tran PV; Hata K; Ingraham HA. 2007. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci 27(50):13624-34. [PubMed: 18077674]  [MGI Ref ID J:130568]

Lichtenauer UD; Duchniewicz M; Kolanczyk M; Hoeflich A; Hahner S; Else T; Bicknell AB; Zemojtel T; Stallings NR; Schulte DM; Kamps MP; Hammer GD; Scheele JS; Beuschlein F. 2007. Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology 148(2):693-704. [PubMed: 17082260]  [MGI Ref ID J:129552]

Luo X; Ikeda Y; Lala D; Rice D; Wong M; Parker KL. 1999. Steroidogenic factor 1 (SF-1) is essential for endocrine development and function. J Steroid Biochem Mol Biol 69(1-6):13-8. [PubMed: 10418976]  [MGI Ref ID J:56097]

Luo X; Ikeda Y; Lala DS; Baity LA; Meade JC; Parker KL. 1995. A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res 21(1-2):517-24. [PubMed: 7588417]  [MGI Ref ID J:31106]

Luo X; Ikeda Y; Schlosser DA; Parker KL. 1995. Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. Mol Endocrinol 9(9):1233-9. [PubMed: 7491115]  [MGI Ref ID J:28763]

Majdic G; Young M; Gomez-Sanchez E; Anderson P; Szczepaniak LS; Dobbins RL; McGarry JD; Parker KL. 2002. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143(2):607-14. [PubMed: 11796516]  [MGI Ref ID J:74977]

Martin LJ; Tremblay JJ. 2010. Nuclear receptors in leydig cell gene expression and function. Biol Reprod 83(1):3-14. [PubMed: 20375256]  [MGI Ref ID J:161974]

Naz RK; Rajesh C. 2005. Gene knockouts that cause female infertility: search for novel contraceptive targets Front Biosci 10:2447-2459. [PubMed: 15970507]  [MGI Ref ID J:103183]

Park SY; Meeks JJ; Raverot G; Pfaff LE; Weiss J; Hammer GD; Jameson JL. 2005. Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. Development 132(10):2415-23. [PubMed: 15829514]  [MGI Ref ID J:98517]

Park SY; Tong M; Jameson JL. 2007. Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development. Endocrinology 148(8):3704-10. [PubMed: 17495005]  [MGI Ref ID J:129625]

Pazin DE; Albrecht KH. 2009. Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation. Dev Dyn 238(11):2877-90. [PubMed: 19842175]  [MGI Ref ID J:153731]

Pelusi C; Ikeda Y; Zubair M; Parker KL. 2008. Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells. Biol Reprod 79(6):1074-83. [PubMed: 18703422]  [MGI Ref ID J:145805]

Roy A; Matzuk MM. 2006. Deconstructing mammalian reproduction: using knockouts to define fertility pathways. Reproduction 131(2):207-19. [PubMed: 16452715]  [MGI Ref ID J:108425]

Segal JP; Stallings NR; Lee CE; Zhao L; Socci N; Viale A; Harris TM; Soares MB; Childs G; Elmquist JK; Parker KL; Friedman JM. 2005. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci 25(16):4181-8. [PubMed: 15843621]  [MGI Ref ID J:145979]

Tran PV; Lee MB; Marin O; Xu B; Jones KR; Reichardt LF; Rubenstein JR; Ingraham HA. 2003. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci 22(4):441-53. [PubMed: 12727442]  [MGI Ref ID J:83384]

Val P; Martinez-Barbera JP; Swain A. 2007. Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134(12):2349-58. [PubMed: 17537799]  [MGI Ref ID J:135126]

Wang D; Ikeda Y; Parker KL; Enders GC. 1997. Germ cell nuclear antigen (GCNA1) expression does not require a gonadal environment or steroidogenic factor 1: examination of GCNA1 in ectopic germ cells and in Ftz-F1 null mice. Mol Reprod Dev 48(2):154-8. [PubMed: 9291464]  [MGI Ref ID J:42707]

Winnay JN; Xu J; O'Malley BW; Hammer GD. 2006. Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function. Endocrinology 147(3):1322-32. [PubMed: 16339206]  [MGI Ref ID J:106985]

Wolfe CA; Van Doren M; Walker HJ; Seney ML; McClellan KM; Tobet SA. 2005. Sex differences in the location of immunochemically defined cell populations in the mouse preoptic area/anterior hypothalamus. Brain Res Dev Brain Res 157(1):34-41. [PubMed: 15939083]  [MGI Ref ID J:99320]

Zhao L; Kim KW; Ikeda Y; Anderson KK; Beck L; Chase S; Tobet SA; Parker KL. 2008. Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22(6):1403-15. [PubMed: 18372344]  [MGI Ref ID J:136159]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is maintained by mating heterozygous breeder pairs.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Heterozygote from the colony
   See control note: Wildtype mice from the colony or DBA/2J mice (Stock No. 000671) may be used as controls.
   000671 DBA/2J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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