Strain Name: |
D2.129P2(B6)-Nr5a1tm1Klp/EiJ |
|---|---|
Stock Number: |
003219 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
D2.129P2(B6)-Nr5a1tm1Klp (Changed: 05-APR-07
) |
|
Ftzf1 (Changed: 15-DEC-04
) | |
| Genes & Alleles | Nr5a1; Nr5a1tm1Klp; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Background Strain DBA/2J Donor Strain B6;129P-Ftzf1tm1Klp (129P2 derived E14TG2a ES cell line) Donating Investigator Keith Parker, Univ Texas Southwestern Medical Center Generation N12+ Appearance
dilute brown
Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5adStrain Description
Mice homozygous for the Nr5a1tm1Klp (formerly Ftzf1tm1Klp) targeted mutation exhibit adrenal and gonadal agenesis. There is also an absence of the ventromedial hypothalamic nucleus leading to impaired expression of gonadotrope specific markers.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Nr5a1tm1Klp | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Keith L Parker | ||
| Common Name(s) | Ftz-F1; Ftz-F1-; Ftzf1tm1Klp; SF-1; Sf1-; Sf-; sf-1-; | ||
| Mutation Made By | Keith Parker, Univ Texas Southwestern Medical Center | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14TG2a | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Nr5a1, nuclear receptor subfamily 5, group A, member 1 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AD4BP; Ad4BP/SF-1; ELP; FTZ1; FTZF1; Ftz-F1; Ftzf1; SF-1; SF1; adrenal 4-binding protein; fushi tarazu 1 factor homolog, (Drosophila); steroidogenic factor 1; | ||
| Molecular Note | A neomycin cassette was inserted into exon 4, which disrupted sequences encoding the second zinc finger of the DNA binding domain. [MGI Ref ID J:35576] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Nr5a1tm1Klp | Heterozygote from the colony | |
| Nr5a1tm1Klp | 000671 DBA/2J | |
| Wildtype mice from the colony or DBA/2J mice (Stock No. 000671) may be used as controls. | ||
| Considerations for Choosing Controls | ||
Colony Maintenance
| Breeding & Husbandry | This strain is maintained by mating heterozygous breeder pairs. |
|---|
Related Strains
Strains carrying other alleles of Nr5a1
007041 B6Ei.129P2-Nr5a1tm2Klp/EiJ 007042 D2.129P2(B6)-Nr5a1tm2Klp/EiJ 006364 FVB-Tg(Nr5a1-cre)2Lowl/J View Strains carrying other alleles of Nr5a1 (3 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Nr5a1tm1Klp related
Developmental Biology Research
Neurodevelopmental Defects
Endocrine Deficiency Research
Hypothalamus/Pituitary Defects
Neurobiology Research
Neurodevelopmental Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
Endocrine Deficiencies Affecting Gonads
Fertility Defects
References
Selected Reference(s)
Additional ReferencesLuo X; Ikeda Y; Parker KL. 1994. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77(4):481-90. [PubMed: 8187173] [MGI Ref ID J:35576]
Price and Supply Information
| Strain Name: | D2.129P2(B6)-Nr5a1tm1Klp/EiJ |
| Stock Number: | 003219 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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