Strain Name:

C.129S2(B6)-Ciitatm1Ccum/J

Stock Number:

003238

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C.129S2(B6)-C2tatm1Ccum/J    (Changed: 26-MAR-07 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain B6,129S-C2tatm1Ccum (129S2 derived D3 ES cell line)
 
Donating InvestigatorDr. Richard A. Flavell,   Yale University School of Medicine

Description
Mice homozygous for the targeted mutation are viable and fertile when housed under specific pathogen-free conditions. Mice do not express conventional MHC class II molecules on the surface of splenic B cells and dendritic cells. In addition, interferon gamma stimulated peritoneal macrophages and somatic tissues from homozygous mutant mice do not express MHC class II molecules. The levels of invarient chain and H2m gene transcripts are substantially decreased in class II transactivator deficient mice. Homozygous mice have very few mature CD4 T cells in the periphery despite MHC class II expression in the thymus.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ciitatm1Ccum allele
003239   B6.129S2-Ciitatm1Ccum/J
005356   NOD.129(B6)-B2mtm1Unc Ciitatm1Ccum/BhsJ
004448   NOD.129S2(B6)-Ciitatm1Ccum/FlvJ
View Strains carrying   Ciitatm1Ccum     (3 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Bare Lymphocyte Syndrome, Type II
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Rheumatoid Arthritis; RA   (CIITA)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ciitatm1Ccum/Ciitatm1Ccum

        involves: 129S2/SvPas * C57BL/6J
  • immune system phenotype
  • abnormal T cell differentiation   (MGI Ref ID J:64283)
  • abnormal cytokine secretion
    • spleen and lymph node cells produced no measurable cytokines at 8 weeks after infection   (MGI Ref ID J:64283)
  • abnormal dendritic cell physiology
    • Bone marrow-derived mutant dendritic cells in culture differentiate in response to GM-CSF despite absence of MHC class II molecules; however, when stimulated with LPS of CpG display about a 2-fold increase in IL-10 expression compared to wild-type   (MGI Ref ID J:96421)
  • abnormal lymphocyte physiology   (MGI Ref ID J:96421)
    • abnormal B cell physiology
      • the expression of IL-10 after stimulation with LPS of IL-4 for 3 days is enhanced in mutant B cells by about 2-3 fold   (MGI Ref ID J:96421)
      • abnormal level of surface class II molecules
        • MHC class II molecules are not detected in organs of mutants, except for interdigitating reticular cells where expression is not induced by interferon-gamma injection   (MGI Ref ID J:31601)
        • bone marrow-derived dendritic cells do not express MHC class II molecules   (MGI Ref ID J:96421)
        • abnormal MHC II cell surface expression on macrophages
          • macrophages do not express MHC II cell surface expression on interferon-gamma stimulation   (MGI Ref ID J:31601)
    • abnormal T cell physiology   (MGI Ref ID J:31601)
      • abnormal CD4-positive, alpha-beta T cell physiology
        • CD4+ T cell responses are significantly reduced to allogeneic stimulation   (MGI Ref ID J:31601)
        • when day 16 fetal liver cells are transferred into wild-type mice, CD4+ T cell development is normal and when wild-type fetal cells are transferred into homozygotes, CD4+ T cells fail to mature   (MGI Ref ID J:31601)
      • decreased T cell proliferation
        • T cells proliferate poorly in response to keyhole limpet hemocyanin stimulation compared to wild-type   (MGI Ref ID J:31601)
  • abnormal popliteal lymph node morphology
    • total numbers of cells in lymph nodes of null increased only slightly after infection with L. amazonensis compared with an 8-fold increase in size of wild-type   (MGI Ref ID J:64283)
  • altered susceptibility to infection   (MGI Ref ID J:64283)
    • decreased susceptibility to parasitic infection
      • after infection with L. Amazonensis, mice show no lesion development up to 11 weeks post infection, reduced cellular infiltration, lower parasite load and few cells in the popliteal lymph nodes draining the foot   (MGI Ref ID J:64283)
      • after infection with L. amazonensis, infected cells contained tightly packed organisms with few parasitophorous vacuole visible whereas infected macrophages in wild-type mice contained only a few organisms which are preferentially located at the edge of parasitophorous vacuoles   (MGI Ref ID J:64283)
    • increased susceptibility to parasitic infection
      • lesions become significantly larger with higher parasitic burdens 16 weeks after infection with L. major, compared to eventual lesion resolution in wild-type mice   (MGI Ref ID J:64283)
  • decreased CD4-positive, alpha beta T cell number
    • mice have reduced numbers of mature CD4+ T cells in the periphery   (MGI Ref ID J:31601)
  • increased CD4-positive, alpha beta T cell number
    • in spleen cells, there is a 4.5-fold increase of CD4+CD69high cells in mutants at 8 weeks after parasite infection   (MGI Ref ID J:64283)
  • increased CD8-positive, alpha-beta T cell number
    • in spleen cell, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection   (MGI Ref ID J:64283)
  • hematopoietic system phenotype
  • abnormal T cell differentiation   (MGI Ref ID J:64283)
  • abnormal lymphocyte physiology   (MGI Ref ID J:96421)
    • abnormal B cell physiology
      • the expression of IL-10 after stimulation with LPS of IL-4 for 3 days is enhanced in mutant B cells by about 2-3 fold   (MGI Ref ID J:96421)
      • abnormal level of surface class II molecules
        • MHC class II molecules are not detected in organs of mutants, except for interdigitating reticular cells where expression is not induced by interferon-gamma injection   (MGI Ref ID J:31601)
        • bone marrow-derived dendritic cells do not express MHC class II molecules   (MGI Ref ID J:96421)
        • abnormal MHC II cell surface expression on macrophages
          • macrophages do not express MHC II cell surface expression on interferon-gamma stimulation   (MGI Ref ID J:31601)
    • abnormal T cell physiology   (MGI Ref ID J:31601)
      • abnormal CD4-positive, alpha-beta T cell physiology
        • CD4+ T cell responses are significantly reduced to allogeneic stimulation   (MGI Ref ID J:31601)
        • when day 16 fetal liver cells are transferred into wild-type mice, CD4+ T cell development is normal and when wild-type fetal cells are transferred into homozygotes, CD4+ T cells fail to mature   (MGI Ref ID J:31601)
      • decreased T cell proliferation
        • T cells proliferate poorly in response to keyhole limpet hemocyanin stimulation compared to wild-type   (MGI Ref ID J:31601)
  • decreased CD4-positive, alpha beta T cell number
    • mice have reduced numbers of mature CD4+ T cells in the periphery   (MGI Ref ID J:31601)
  • increased CD4-positive, alpha beta T cell number
    • in spleen cells, there is a 4.5-fold increase of CD4+CD69high cells in mutants at 8 weeks after parasite infection   (MGI Ref ID J:64283)
  • increased CD8-positive, alpha-beta T cell number
    • in spleen cell, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection   (MGI Ref ID J:64283)

Ciitatm1Ccum/Ciitatm1Ccum

        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • abnormal level of surface class II molecules
    • class II surface expression in the cortex and medulla of the thymus is very patchy   (MGI Ref ID J:67941)
    • unactivated or activated B cells do not express class II on the surface   (MGI Ref ID J:67941)
    • class II expression is absent on CD11c+ dendritic cells   (MGI Ref ID J:67941)
  • hematopoietic system phenotype
  • abnormal level of surface class II molecules
    • class II surface expression in the cortex and medulla of the thymus is very patchy   (MGI Ref ID J:67941)
    • unactivated or activated B cells do not express class II on the surface   (MGI Ref ID J:67941)
    • class II expression is absent on CD11c+ dendritic cells   (MGI Ref ID J:67941)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      MHC class II associated invariant chain deficient
      MHC class II defects
      MHC class II deficient
      T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      T cell deficiency

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class II associated invariant chain deficiency
      MHC class II defects
      T cell deficiency

Ciitatm1Ccum related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class II defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ciitatm1Ccum
Allele Name targeted mutation 1, Cheong-Hee Chang
Allele Type Targeted (Null/Knockout)
Common Name(s) C2tatm1Ccum; CIITA C-; CIITA-; MHC classII-;
Mutation Made ByDr. Cheong-Hee Chang,   Indiana University
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Ciita, class II transactivator
Chromosome 16
Gene Common Name(s) C2TA; C2ta; CIITAIV; EG669998; Gm9475; MHC2TA; NLRA; predicted gene 9475; predicted gene, EG669998;
Molecular Note A genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. [MGI Ref ID J:31601]

Genotyping

Genotyping Information

Genotyping Protocols

Ciitatm1Ccum, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Fikrig E; Barthold SW; Chen M; Chang CH; Flavell RA. 1997. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. J Immunol 159(11):5682-6. [PubMed: 9548512]  [MGI Ref ID J:109903]

Additional References

Ciitatm1Ccum related

Aichinger M; Wu C; Nedjic J; Klein L. 2013. Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. J Exp Med 210(2):287-300. [PubMed: 23382543]  [MGI Ref ID J:196474]

Benito AI; Milner LA; Leisenring W; Deeg HJ; Woolfrey AE. 2001. Absence of major histocompatibility class II expression does not impair hematopoiesis in mice. Exp Hematol 29(9):1070-5. [PubMed: 11532347]  [MGI Ref ID J:111611]

Benlagha K; Park SH; Guinamard R; Forestier C; Karlsson L; Chang CH; Bendelac A. 2004. Mechanisms governing B cell developmental defects in invariant chain-deficient mice. J Immunol 172(4):2076-83. [PubMed: 14764672]  [MGI Ref ID J:87989]

Broxmeyer HE; Cooper S; Hangoc G; Chang CH. 2006. Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins. Exp Hematol 34(8):1078-84. [PubMed: 16863914]  [MGI Ref ID J:111903]

Buch T; Polic B; Clausen BE; Weiss S; Akilli-Ozturk O; Chang CH; Flavell R; Schulz A; Jonjic S; Waisman A; Forster I. 2006. MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency. Blood 107(4):1434-44. [PubMed: 16254146]  [MGI Ref ID J:129309]

Chang CH; Guerder S; Hong SC; van Ewijk W; Flavell RA. 1996. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity 4(2):167-78. [PubMed: 8624807]  [MGI Ref ID J:31601]

Chen L; Jay DC; Fairbanks JD; He X; Jensen PE. 2011. An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol 187(12):6463-72. [PubMed: 22084437]  [MGI Ref ID J:180389]

Choi EY; Jung KC; Park HJ; Chung DH; Song JS; Yang SD; Simpson E; Park SH. 2005. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23(4):387-96. [PubMed: 16226504]  [MGI Ref ID J:113276]

Chou SD; Khan AN; Magner WJ; Tomasi TB. 2005. Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. Int Immunol 17(11):1483-94. [PubMed: 16210330]  [MGI Ref ID J:104221]

Clausen BE; Waldburger JM; Schwenk F; Barras E; Mach B; Rajewsky K; Forster I; Reith W. 1998. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8(2):143-55. [PubMed: 9491996]  [MGI Ref ID J:67941]

Creusot RJ; Yaghoubi SS; Kodama K; Dang DN; Dang VH; Breckpot K; Thielemans K; Gambhir SS; Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127(2):176-87. [PubMed: 18337172]  [MGI Ref ID J:133579]

Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432]  [MGI Ref ID J:124622]

Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863]  [MGI Ref ID J:139094]

Elliott EA; Drake JR; Amigorena S; Elsemore J; Webster P; Mellman I; Flavell RA. 1994. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med 179(2):681-94. [PubMed: 8294875]  [MGI Ref ID J:65917]

Eppert BL; Wortham BW; Flury JL; Borchers MT. 2013. Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol 190(3):1331-40. [PubMed: 23264660]  [MGI Ref ID J:192605]

Gourley T; Roys S; Lukacs NW; Kunkel SL; Flavell RA; Chang CH. 1999. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Immunity 10(3):377-86. [PubMed: 10204493]  [MGI Ref ID J:54057]

Gourley TS; Patel DR; Nickerson K; Hong SC; Chang CH. 2002. Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator. J Immunol 168(9):4414-9. [PubMed: 11970984]  [MGI Ref ID J:112146]

Green EA; Wong FS; Eshima K; Mora C; Flavell RA. 2000. Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells. J Exp Med 191(2):225-38. [PubMed: 10637268]  [MGI Ref ID J:59409]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Hinterberger M; Aichinger M; da Costa OP; Voehringer D; Hoffmann R; Klein L. 2010. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol 11(6):512-9. [PubMed: 20431619]  [MGI Ref ID J:160615]

Jay DC; Reed-Loisel LM; Jensen PE. 2008. Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J Immunol 180(5):2805-14. [PubMed: 18292501]  [MGI Ref ID J:131725]

Kuipers H; Soullie T; Hammad H; Willart M; Kool M; Hijdra D; Hoogsteden HC; Lambrecht BN. 2009. Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells. J Leukoc Biol 85(1):64-70. [PubMed: 18923103]  [MGI Ref ID J:143272]

Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. [PubMed: 16081800]  [MGI Ref ID J:107508]

Lauvau G; Vijh S; Kong P; Horng T; Kerksiek K; Serbina N; Tuma RA; Pamer EG. 2001. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science 294(5547):1735-9. [PubMed: 11721060]  [MGI Ref ID J:133596]

Lee YJ; Jeon YK; Kang BH; Chung DH; Park CG; Shin HY; Jung KC; Park SH. 2010. Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. J Exp Med 207(1):237-46, S1-7. [PubMed: 20038602]  [MGI Ref ID J:156545]

Li W; Kim MG; Gourley TS; McCarthy BP; Sant'Angelo DB; Chang CH. 2005. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 23(4):375-86. [PubMed: 16226503]  [MGI Ref ID J:113275]

Li W; Sofi MH; Yeh N; Sehra S; McCarthy BP; Patel DR; Brutkiewicz RR; Kaplan MH; Chang CH. 2007. Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med 204(9):2145-57. [PubMed: 17724129]  [MGI Ref ID J:126084]

Ling W; Zhang J; Yuan Z; Ren G; Zhang L; Chen X; Rabson AB; Roberts AI; Wang Y; Shi Y. 2014. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 74(5):1576-87. [PubMed: 24452999]  [MGI Ref ID J:208149]

Mora C; Wong FS; Chang CH; Flavell RA. 1999. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. J Immunol 162(8):4576-88. [PubMed: 10201997]  [MGI Ref ID J:106081]

Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. [PubMed: 22908323]  [MGI Ref ID J:191814]

Otten LA; Leibundgut-Landmann S; Huarte J; Kos-Braun IC; Lavanchy C; Barras E; Borisch B; Steimle V; Acha-Orbea H; Reith W. 2006. Revisiting the specificity of the MHC class II transactivator CIITA in vivo. Eur J Immunol 36(6):1548-58. [PubMed: 16703565]  [MGI Ref ID J:152061]

Patel DR; Kaplan MH; Chang CH. 2004. Altered Th1 cell differentiation programming by CIITA deficiency. J Immunol 173(9):5501-8. [PubMed: 15494498]  [MGI Ref ID J:93745]

Pihlgren M; Silva AB; Madani R; Giriens V; Waeckerle-Men Y; Fettelschoss A; Hickman DT; Lopez-Deber MP; Ndao DM; Vukicevic M; Buccarello AL; Gafner V; Chuard N; Reis P; Piorkowska K; Pfeifer A; Kundig TM; Muhs A; Johansen P. 2013. TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. Blood 121(1):85-94. [PubMed: 23144170]  [MGI Ref ID J:192819]

Qiao Y; Zhu L; Sofi H; Lapinski PE; Horai R; Mueller K; Stritesky GL; He X; Teh HS; Wiest DL; Kappes DJ; King PD; Hogquist KA; Schwartzberg PL; Sant'Angelo DB; Chang CH. 2012. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A 109(40):16264-9. [PubMed: 22988097]  [MGI Ref ID J:190112]

Romagnoli PA; Premenko-Lanier MF; Loria GD; Altman JD. 2013. CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs. PLoS One 8(2):e56999. [PubMed: 23441229]  [MGI Ref ID J:199409]

Rubino SJ; Geddes K; Magalhaes JG; Streutker C; Philpott DJ; Girardin SE. 2013. Constitutive induction of intestinal Tc17 cells in the absence of hematopoietic cell-specific MHC class II expression. Eur J Immunol 43(11):2896-906. [PubMed: 23881368]  [MGI Ref ID J:203009]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Sofi MH; Liu Z; Zhu L; Yu Q; Kaplan MH; Chang CH. 2010. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol 47(6):1262-8. [PubMed: 20080304]  [MGI Ref ID J:158374]

Soong L; Chang CH; Sun J; Longley BJ Jr; Ruddle NH; Flavell RA; McMahon-Pratt D. 1997. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J Immunol 158(11):5374-83. [PubMed: 9164958]  [MGI Ref ID J:64283]

Taniguchi RT; Devoss JJ; Moon JJ; Sidney J; Sette A; Jenkins MK; Anderson MS. 2012. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A 109(20):7847-52. [PubMed: 22552229]  [MGI Ref ID J:184783]

Tazawa H; Irei T; Tanaka Y; Igarashi Y; Tashiro H; Ohdan H. 2013. Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates. Blood 122(15):2582-90. [PubMed: 23943651]  [MGI Ref ID J:203264]

Trautmann T; Kozik JH; Carambia A; Richter K; Lischke T; Schwinge D; Mittrucker HW; Lohse AW; Oxenius A; Wiegard C; Herkel J. 2014. CD4+ T-cell help is required for effective CD8+ T cell-mediated resolution of acute viral hepatitis in mice. PLoS One 9(1):e86348. [PubMed: 24466045]  [MGI Ref ID J:212565]

Winer DA; Winer S; Shen L; Wadia PP; Yantha J; Paltser G; Tsui H; Wu P; Davidson MG; Alonso MN; Leong HX; Glassford A; Caimol M; Kenkel JA; Tedder TF; McLaughlin T; Miklos DB; Dosch HM; Engleman EG. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17(5):610-7. [PubMed: 21499269]  [MGI Ref ID J:171607]

Xu Y; Luchsinger L; Lucey EC; Smith BD. 2011. The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis. Am J Respir Cell Mol Biol 44(6):898-905. [PubMed: 20705943]  [MGI Ref ID J:185026]

Xu Y; McDonald J; Perloff E; Buttice G; Schreiber BM; Smith BD. 2007. Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Mol Immunol 44(7):1720-32. [PubMed: 16982097]  [MGI Ref ID J:115938]

Yang SJ; Ahn S; Park CS; Holmes KL; Westrup J; Chang CH; Kim MG. 2006. The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development. Int Immunol 18(5):729-39. [PubMed: 16569676]  [MGI Ref ID J:108547]

Yee CS; Yao Y; Li P; Klemsz MJ; Blum JS; Chang CH. 2004. Cathepsin E: a novel target for regulation by class II transactivator. J Immunol 172(9):5528-34. [PubMed: 15100295]  [MGI Ref ID J:89650]

Yee CS; Yao Y; Xu Q; McCarthy B; Sun-Lin D; Tone M; Waldmann H; Chang CH. 2005. Enhanced production of IL-10 by dendritic cells deficient in CIITA. J Immunol 174(3):1222-9. [PubMed: 15661876]  [MGI Ref ID J:96421]

Young HY; Zucker P; Flavell RA; Jevnikar AM; Singh B. 2004. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78(4):509-15. [PubMed: 15446308]  [MGI Ref ID J:107051]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Use restrictions apply, see Policy on Licensing and Use Restrictions.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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