Strain Name:

C57BL/6-Tnfrsf1atm1Imx/J

Stock Number:

003242

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Availability:

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Homozygous p55 (Tnfrsf1atm1Imx) mice show defects in resistance to intracellular pathogens and are resistant to the lethal effects of LPS . These mice are useful in studies of tumor necrosis factor (TNF) signaling on various biological effects including inflammatory responses.

Description

Strain Information

Former Names Tnfr1    (Changed: 15-DEC-04 )
Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN3F1 (17-JUL-13)
Generation Definitions
 
Donating InvestigatorDr. Jacques Peschon,   Amgen

Description
Mice homozygous for the Tnfrsf1atm1Imx targeted mutation (formerly Tnfr1tm1Imx, p55 deficient) show defects in resistance to intracellular pathogens and are resistant to the lethal effects of LPS administration in conjunction with D-galactosamine. Pulmonary inflammatory responses are diminished in p55 deficient mice. There are also defects in Peyer's patch development, splenic architecture, formation of germinal centers, and liver regeneration. TNFRSF1 deficient mice display increased susceptibility to atherosclerosis when maintained on a high fat diet.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tnfrsf1atm1Imx allele
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
View Strains carrying   Tnfrsf1atm1Imx     (2 strains)

Strains carrying other alleles of Tnfrsf1a
002818   B6.129-Tnfrsf1atm1Mak/J
View Strains carrying other alleles of Tnfrsf1a     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Periodic Fever, Familial, Autosomal Dominant
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Multiple Sclerosis, Susceptibility to, 5; MS5   (TNFRSF1A)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        C57BL/6-Tnfrsf1atm1Imx
  • immune system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • decreased inflammatory response
    • decreased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control   (MGI Ref ID J:45147)
    • decreased susceptibility to endotoxin shock
      • exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS)   (MGI Ref ID J:45147)
  • increased circulating tumor necrosis factor level
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • increased susceptibility to bacterial infection
    • 100% of mice succumb to a sublethal dose of Listeria monocytogenes 4 days post-infection   (MGI Ref ID J:45147)
  • lung inflammation
    • lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
    • reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • homeostasis/metabolism phenotype
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
  • increased circulating tumor necrosis factor level
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • hematopoietic system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • liver/biliary system phenotype
  • abnormal oval cell physiology
    • reduced oval cell response to a choline deficient diet and ethionine in the drinking water   (MGI Ref ID J:66448)
  • tumorigenesis
  • decreased tumor incidence
    • lower incidence of tumors after 9 months on a choline deficient diet and ethionine in the drinking water   (MGI Ref ID J:66448)
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • nervous system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • abnormal nervous system physiology   (MGI Ref ID J:112713)
    • abnormal cerebellar granule cell proliferation
      • 25% increased labelling with BrdU of mature cells in the gubgranular zone/granule cell layer   (MGI Ref ID J:112713)
    • abnormal glutamate-mediated receptor currents
      • increased glutamate currents   (MGI Ref ID J:152590)
    • decreased susceptibility to dopaminergic neuron neurotoxicity
      • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
  • respiratory system phenotype
  • abnormal airway responsiveness   (MGI Ref ID J:143836)
    • fail to develop airway hyper responsiveness after "OVA" sensitization   (MGI Ref ID J:120174)
  • abnormal respiratory mechanics
    • peak inspiratory pressure is not affected by 2 hours of high stretch ventilation whereas controls experience rapid increases after 80-90 minutes   (MGI Ref ID J:143836)
  • lung inflammation
    • lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
    • reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • integument phenotype
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • cellular phenotype
  • abnormal cerebellar granule cell proliferation
    • 25% increased labelling with BrdU of mature cells in the gubgranular zone/granule cell layer   (MGI Ref ID J:112713)
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        C57BL/6-Tnfrsf1atm1Imx/J
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice   (MGI Ref ID J:160543)
  • immune system phenotype
  • abnormal chemokine secretion
    • TNF-stimulated peritoneal macrophages produce less CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • abnormal follicular dendritic cell morphology
    • mice lack an intact follicular dendritic cell network and defined B- and T-cell zones unlike in wild-type mice   (MGI Ref ID J:160543)
  • abnormal macrophage physiology
    • TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • decreased circulating interleukin-6 level
    • following LPS challenge   (MGI Ref ID J:160543)
  • decreased interleukin-6 secretion
    • TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • decreased susceptibility to endotoxin shock
    • mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice   (MGI Ref ID J:160543)
  • increased circulating tumor necrosis factor level
    • following LPS challenge   (MGI Ref ID J:160543)
  • homeostasis/metabolism phenotype
  • decreased circulating interleukin-6 level
    • following LPS challenge   (MGI Ref ID J:160543)
  • increased circulating tumor necrosis factor level
    • following LPS challenge   (MGI Ref ID J:160543)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        involves: C57BL/6
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • no mice treated with TNF die unlike wild-type mice   (MGI Ref ID J:210950)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice infected with Listeria monocytogenes die unlike wild-type mice   (MGI Ref ID J:210950)
  • immune system phenotype
  • impaired humoral immune response
    • mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice   (MGI Ref ID J:210950)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice infected with Listeria monocytogenes die unlike wild-type mice   (MGI Ref ID J:210950)
  • cellular phenotype
  • increased sensitivity to induced cell death
    • in mouse embryonic fibroblasts exposed to hypoxia   (MGI Ref ID J:173568)
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice   (MGI Ref ID J:210950)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal immune system physiology   (MGI Ref ID J:45147)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Tnfrsf1atm1Mak/Tnfrsf1a+

        involves: 129S2/SvPas
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • no mice treated with TNF die unlike all wild-type mice   (MGI Ref ID J:210950)
  • immune system phenotype
  • decreased circulating interleukin-6 level
    • decreased induction in TNF-treated mice   (MGI Ref ID J:210950)
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice   (MGI Ref ID J:210950)
  • decreased circulating interleukin-6 level
    • decreased induction in TNF-treated mice   (MGI Ref ID J:210950)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tnfrsf1atm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tnfrsf1atm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (Null/Knockout)
Common Name(s) Preschon Tnfrsf1a-; TNF-alpha-R1; TNFR1-; TNFR-; TNFRI-; Tnfrsf1atm1Imx; p55 KO; p55-;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of OriginC57BL/6
Gene Symbol and Name Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
Chromosome 6
Gene Common Name(s) CD120a; FPF; MS5; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR-1; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRI; TNFRp55; TNFalpha-R1; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. [MGI Ref ID J:110548] [MGI Ref ID J:45147]

Genotyping

Genotyping Information

Genotyping Protocols

Tnfrsf1atm1Imx,

Separated MCA


Tnfrsf1atm1Imx, High Resolution Melting
Tnfrsf1atm1Imx, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Riehl TE; Newberry RD; Lorenz RG; Stenson WF. 2004. TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. Am J Physiol Gastrointest Liver Physiol 286(1):G166-73. [PubMed: 14525729]  [MGI Ref ID J:87602]

Tnfrsf1atm1Imx related

Adolph TE; Tomczak MF; Niederreiter L; Ko HJ; Bock J; Martinez-Naves E; Glickman JN; Tschurtschenthaler M; Hartwig J; Hosomi S; Flak MB; Cusick JL; Kohno K; Iwawaki T; Billmann-Born S; Raine T; Bharti R; Lucius R; Kweon MN; Marciniak SJ; Choi A; Hagen SJ; Schreiber S; Rosenstiel P; Kaser A; Blumberg RS. 2013. Paneth cells as a site of origin for intestinal inflammation. Nature 503(7475):272-6. [PubMed: 24089213]  [MGI Ref ID J:206084]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Allam R; Darisipudi MN; Rupanagudi KV; Lichtnekert J; Tschopp J; Anders HJ. 2011. Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1{beta} Secretion by Activating the NLRP3 Inflammasome. J Immunol 186(5):2714-8. [PubMed: 21278344]  [MGI Ref ID J:169383]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Arnott CH; Scott KA; Moore RJ; Robinson SC; Thompson RG; Balkwill FR. 2004. Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene 23(10):1902-10. [PubMed: 14661063]  [MGI Ref ID J:89088]

Artis D; Humphreys NE; Bancroft AJ; Rothwell NJ; Potten CS; Grencis RK. 1999. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190(7):953-62. [PubMed: 10510085]  [MGI Ref ID J:115088]

Balosso S; Ravizza T; Pierucci M; Calcagno E; Invernizzi R; Di Giovanni G; Esposito E; Vezzani A. 2009. Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: implications for seizure susceptibility. Neuroscience 161(1):293-300. [PubMed: 19285115]  [MGI Ref ID J:152590]

Baluk P; Yao LC; Feng J; Romano T; Jung SS; Schreiter JL; Yan L; Shealy DJ; McDonald DM. 2009. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest 119(10):2954-64. [PubMed: 19759514]  [MGI Ref ID J:154641]

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Baseta JG; Stutman O. 2000. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. J Immunol 165(10):5621-30. [PubMed: 11067918]  [MGI Ref ID J:112282]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Beamer CA; Holian A. 2007. Antigen-presenting cell population dynamics during murine silicosis. Am J Respir Cell Mol Biol 37(6):729-38. [PubMed: 17641296]  [MGI Ref ID J:141645]

Belisle SE; Tisoncik JR; Korth MJ; Carter VS; Proll SC; Swayne DE; Pantin-Jackwood M; Tumpey TM; Katze MG. 2010. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 84(24):12576-88. [PubMed: 20926563]  [MGI Ref ID J:166538]

Berta T; Park CK; Xu ZZ; Xie RG; Liu T; Lu N; Liu YC; Ji RR. 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest 124(3):1173-86. [PubMed: 24531553]  [MGI Ref ID J:209726]

Bertok S; Wilson MR; Dorr AD; Dokpesi JO; O'Dea KP; Marczin N; Takata M. 2011. Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice. Am J Physiol Lung Cell Mol Physiol 300(5):L781-9. [PubMed: 21378027]  [MGI Ref ID J:174247]

Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. [PubMed: 18192488]  [MGI Ref ID J:134193]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Blaauboer SM; Gabrielle VD; Jin L. 2014. MPYS/STING-mediated TNF-alpha, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol 192(1):492-502. [PubMed: 24307739]  [MGI Ref ID J:207163]

Boone DL; Turer EE; Lee EG; Ahmad RC; Wheeler MT; Tsui C; Hurley P; Chien M; Chai S; Hitotsumatsu O; McNally E; Pickart C; Ma A. 2004. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5(10):1052-60. [PubMed: 15334086]  [MGI Ref ID J:92694]

Borges VM; Vandivier RW; McPhillips KA; Kench JA; Morimoto K; Groshong SD; Richens TR; Graham BB; Muldrow AM; Van Heule L; Henson PM; Janssen WJ. 2009. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol 297(4):L586-95. [PubMed: 19648283]  [MGI Ref ID J:154222]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Stachnick G; Castaneda D; Nayar J; Sriramarao P. 2001. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol 24(3):304-11. [PubMed: 11245629]  [MGI Ref ID J:114289]

Bruce AJ; Boling W; Kindy MS; Peschon J; Kraemer PJ; Carpenter MK; Holtsberg FW; Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2(7):788-94. [PubMed: 8673925]  [MGI Ref ID J:33864]

Bulua AC; Simon A; Maddipati R; Pelletier M; Park H; Kim KY; Sack MN; Kastner DL; Siegel RM. 2011. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208(3):519-33. [PubMed: 21282379]  [MGI Ref ID J:176847]

Calder CJ; Nicholson LB; Dick AD. 2005. A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol 175(10):6286-93. [PubMed: 16272279]  [MGI Ref ID J:119347]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Campbell LA; Nosaka T; Rosenfeld ME; Yaraei K; Kuo CC. 2005. Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice. Infect Immun 73(5):3164-5. [PubMed: 15845526]  [MGI Ref ID J:97619]

Campos-Neto A; Ovendale P; Bement T; Koppi TA; Fanslow WC; Rossi MA; Alderson MR. 1998. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 160(5):2037-41. [PubMed: 9498737]  [MGI Ref ID J:123032]

Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. [PubMed: 21641402]  [MGI Ref ID J:173471]

Chandrasekharan UM; Siemionow M; Unsal M; Yang L; Poptic E; Bohn J; Ozer K; Zhou Z; Howe PH; Penn M; DiCorleto PE. 2007. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood 109(5):1938-44. [PubMed: 17068152]  [MGI Ref ID J:145363]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Chen H; Koupenova M; Yang D; Sume SS; Trackman PC; Ravid K. 2011. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-alpha signaling. Exp Hematol 39(5):525-30. [PubMed: 21320567]  [MGI Ref ID J:177966]

Chen LW; Egan L; Li ZW; Greten FR; Kagnoff MF; Karin M. 2003. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-81. [PubMed: 12692538]  [MGI Ref ID J:83313]

Chen MC; Mudge CS; Klumpp DJ. 2006. Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis. Am J Physiol Renal Physiol 291(4):F741-9. [PubMed: 16622179]  [MGI Ref ID J:144913]

Chen SE; Gerken E; Zhang Y; Zhan M; Mohan RK; Li AS; Reid MB; Li YP. 2005. Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle. Am J Physiol Cell Physiol 289(5):C1179-87. [PubMed: 16079187]  [MGI Ref ID J:104990]

Chen SE; Jin B; Li YP. 2007. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292(5):C1660-71. [PubMed: 17151142]  [MGI Ref ID J:125884]

Chiu H; Gardner CR; Dambach DM; Brittingham JA; Durham SK; Laskin JD; Laskin DL. 2003. Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense. Am J Physiol Gastrointest Liver Physiol 285(5):G959-66. [PubMed: 12842828]  [MGI Ref ID J:86545]

Choi S; Park YS; Koga T; Treloar A; Kim KC. 2011. TNF-alpha is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol 44(2):255-60. [PubMed: 20448050]  [MGI Ref ID J:183356]

Choksi S; Lin Y; Pobezinskaya Y; Chen L; Park C; Morgan M; Li T; Jitkaew S; Cao X; Kim YS; Kim HS; Levitt P; Shih G; Birre M; Deng CX; Liu ZG. 2011. A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2. Mol Cell 42(5):597-609. [PubMed: 21658601]  [MGI Ref ID J:173568]

Chopra M; Lang I; Salzmann S; Pachel C; Kraus S; Bauerlein CA; Brede C; Garrote AL; Mattenheimer K; Ritz M; Schwinn S; Graf C; Schafer V; Frantz S; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One 8(9):e75737. [PubMed: 24098720]  [MGI Ref ID J:207733]

Chopra M; Riedel SS; Biehl M; Krieger S; von Krosigk V; Bauerlein CA; Brede C; Jordan Garrote AL; Kraus S; Schafer V; Ritz M; Mattenheimer K; Degla A; Mottok A; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6):1296-303. [PubMed: 23385062]  [MGI Ref ID J:198326]

Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. [PubMed: 18931327]  [MGI Ref ID J:159269]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Tnfrsf1atm1Imx  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Tnfrsf1atm1Imx x Homozygous for Tnfrsf1atm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Tnfrsf1atm1Imx  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Tnfrsf1atm1Imx x Homozygous for Tnfrsf1atm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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