Strain Name:


Stock Number:


Order this mouse


Repository- Live

Common Names: p55-;    
Homozygous p55 (Tnfrsf1atm1Imx) mice show defects in resistance to intracellular pathogens and are resistant to the lethal effects of LPS . These mice are useful in studies of tumor necrosis factor (TNF) signaling on various biological effects including inflammatory responses.


Strain Information

Former Names Tnfr1    (Changed: 15-DEC-04 )
Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN3F4 (17-JUN-15)
Generation Definitions
Donating InvestigatorDr. Jacques Peschon,   Amgen

Mice homozygous for the Tnfrsf1atm1Imx targeted mutation (formerly Tnfr1tm1Imx, p55 deficient) show defects in resistance to intracellular pathogens and are resistant to the lethal effects of LPS administration in conjunction with D-galactosamine. Pulmonary inflammatory responses are diminished in p55 deficient mice. There are also defects in Peyer's patch development, splenic architecture, formation of germinal centers, and liver regeneration. TNFRSF1 deficient mice display increased susceptibility to atherosclerosis when maintained on a high fat diet.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tnfrsf1atm1Imx allele
003243   B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
024314   NOD.Cg-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/J
View Strains carrying   Tnfrsf1atm1Imx     (3 strains)

Strains carrying other alleles of Tnfrsf1a
002818   B6.129-Tnfrsf1atm1Mak/J
View Strains carrying other alleles of Tnfrsf1a     (1 strain)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Periodic Fever, Familial, Autosomal Dominant
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Multiple Sclerosis, Susceptibility to, 5; MS5   (TNFRSF1A)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


  • immune system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • decreased inflammatory response
    • decreased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control   (MGI Ref ID J:45147)
    • decreased susceptibility to endotoxin shock
      • exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS)   (MGI Ref ID J:45147)
  • increased circulating tumor necrosis factor level
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • increased susceptibility to bacterial infection
    • 100% of mice succumb to a sublethal dose of Listeria monocytogenes 4 days post-infection   (MGI Ref ID J:45147)
  • lung inflammation
    • lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
    • reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • homeostasis/metabolism phenotype
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
  • increased circulating tumor necrosis factor level
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • hematopoietic system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • liver/biliary system phenotype
  • abnormal oval cell physiology
    • reduced oval cell response to a choline deficient diet and ethionine in the drinking water   (MGI Ref ID J:66448)
  • tumorigenesis
  • decreased tumor incidence
    • lower incidence of tumors after 9 months on a choline deficient diet and ethionine in the drinking water   (MGI Ref ID J:66448)
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • nervous system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells 23% lower than controls after epileptic stimulation   (MGI Ref ID J:112713)
  • abnormal nervous system physiology   (MGI Ref ID J:112713)
    • abnormal cerebellar granule cell precursor proliferation
      • 25% increased labelling with BrdU of mature cells in the gubgranular zone/granule cell layer   (MGI Ref ID J:112713)
    • abnormal glutamate-mediated receptor currents
      • increased glutamate currents   (MGI Ref ID J:152590)
    • decreased susceptibility to dopaminergic neuron neurotoxicity
      • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
  • respiratory system phenotype
  • abnormal airway responsiveness   (MGI Ref ID J:143836)
    • fail to develop airway hyper responsiveness after "OVA" sensitization   (MGI Ref ID J:120174)
  • abnormal respiratory mechanics
    • peak inspiratory pressure is not affected by 2 hours of high stretch ventilation whereas controls experience rapid increases after 80-90 minutes   (MGI Ref ID J:143836)
  • lung inflammation
    • lower levels of Il5, Il12, Il13, and Ifn-gamma in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
    • reduced numbers of T-alpha,beta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • integument phenotype
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • cellular phenotype
  • abnormal cerebellar granule cell precursor proliferation
    • 25% increased labelling with BrdU of mature cells in the gubgranular zone/granule cell layer   (MGI Ref ID J:112713)
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 63% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)


  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice   (MGI Ref ID J:160543)
  • immune system phenotype
  • abnormal chemokine secretion
    • TNF-stimulated peritoneal macrophages produce less CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • abnormal follicular dendritic cell morphology
    • mice lack an intact follicular dendritic cell network and defined B- and T-cell zones unlike in wild-type mice   (MGI Ref ID J:160543)
  • abnormal macrophage physiology
    • TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • decreased circulating interleukin-6 level
    • following LPS challenge   (MGI Ref ID J:160543)
  • decreased interleukin-6 secretion
    • TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells   (MGI Ref ID J:160543)
  • decreased susceptibility to endotoxin shock
    • mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice   (MGI Ref ID J:160543)
  • increased circulating tumor necrosis factor level
    • following LPS challenge   (MGI Ref ID J:160543)
  • homeostasis/metabolism phenotype
  • decreased circulating interleukin-6 level
    • following LPS challenge   (MGI Ref ID J:160543)
  • increased circulating tumor necrosis factor level
    • following LPS challenge   (MGI Ref ID J:160543)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells   (MGI Ref ID J:160543)


        involves: C57BL/6
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • no mice treated with TNF die unlike wild-type mice   (MGI Ref ID J:210950)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice infected with Listeria monocytogenes die unlike wild-type mice   (MGI Ref ID J:210950)
  • immune system phenotype
  • impaired humoral immune response
    • mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice   (MGI Ref ID J:210950)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice infected with Listeria monocytogenes die unlike wild-type mice   (MGI Ref ID J:210950)
  • cellular phenotype
  • increased sensitivity to induced cell death
    • in mouse embryonic fibroblasts exposed to hypoxia   (MGI Ref ID J:173568)
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice   (MGI Ref ID J:210950)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal immune system physiology   (MGI Ref ID J:45147)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services for customized breeding options.


        involves: 129S2/SvPas
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • no mice treated with TNF die unlike all wild-type mice   (MGI Ref ID J:210950)
  • immune system phenotype
  • decreased circulating interleukin-6 level
    • decreased induction in TNF-treated mice   (MGI Ref ID J:210950)
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice   (MGI Ref ID J:210950)
  • decreased circulating interleukin-6 level
    • decreased induction in TNF-treated mice   (MGI Ref ID J:210950)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tnfrsf1atm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tnfrsf1atm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (Null/Knockout)
Common Name(s) Preschon Tnfrsf1a-; TNF-alpha-R1; TNFR1-; TNFR-; TNFRI-; Tnfrsf1atm1Imx; p55 KO; p55-;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of OriginC57BL/6
Gene Symbol and Name Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
Chromosome 6
Gene Common Name(s) CD120a; FPF; MS5; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR-1; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRI; TNFRp55; TNFalpha-R1; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. [MGI Ref ID J:110548] [MGI Ref ID J:45147]


Genotyping Information

Genotyping Protocols

Tnfrsf1atm1Imx-Alternate 3, High Resolution Melting

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Riehl TE; Newberry RD; Lorenz RG; Stenson WF. 2004. TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. Am J Physiol Gastrointest Liver Physiol 286(1):G166-73. [PubMed: 14525729]  [MGI Ref ID J:87602]

Tnfrsf1atm1Imx related

Adolph TE; Tomczak MF; Niederreiter L; Ko HJ; Bock J; Martinez-Naves E; Glickman JN; Tschurtschenthaler M; Hartwig J; Hosomi S; Flak MB; Cusick JL; Kohno K; Iwawaki T; Billmann-Born S; Raine T; Bharti R; Lucius R; Kweon MN; Marciniak SJ; Choi A; Hagen SJ; Schreiber S; Rosenstiel P; Kaser A; Blumberg RS. 2013. Paneth cells as a site of origin for intestinal inflammation. Nature 503(7475):272-6. [PubMed: 24089213]  [MGI Ref ID J:206084]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Allam R; Darisipudi MN; Rupanagudi KV; Lichtnekert J; Tschopp J; Anders HJ. 2011. Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1{beta} Secretion by Activating the NLRP3 Inflammasome. J Immunol 186(5):2714-8. [PubMed: 21278344]  [MGI Ref ID J:169383]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Arnott CH; Scott KA; Moore RJ; Robinson SC; Thompson RG; Balkwill FR. 2004. Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene 23(10):1902-10. [PubMed: 14661063]  [MGI Ref ID J:89088]

Artis D; Humphreys NE; Bancroft AJ; Rothwell NJ; Potten CS; Grencis RK. 1999. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190(7):953-62. [PubMed: 10510085]  [MGI Ref ID J:115088]

Balosso S; Ravizza T; Pierucci M; Calcagno E; Invernizzi R; Di Giovanni G; Esposito E; Vezzani A. 2009. Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: implications for seizure susceptibility. Neuroscience 161(1):293-300. [PubMed: 19285115]  [MGI Ref ID J:152590]

Baluk P; Yao LC; Feng J; Romano T; Jung SS; Schreiter JL; Yan L; Shealy DJ; McDonald DM. 2009. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest 119(10):2954-64. [PubMed: 19759514]  [MGI Ref ID J:154641]

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Barrios B; Baez NS; Reynolds D; Iribarren P; Cejas H; Young HA; Rodriguez-Galan MC. 2014. Abrogation of TNFalpha production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9(2):e90116. [PubMed: 24587231]  [MGI Ref ID J:214472]

Baseta JG; Stutman O. 2000. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. J Immunol 165(10):5621-30. [PubMed: 11067918]  [MGI Ref ID J:112282]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Beamer CA; Holian A. 2007. Antigen-presenting cell population dynamics during murine silicosis. Am J Respir Cell Mol Biol 37(6):729-38. [PubMed: 17641296]  [MGI Ref ID J:141645]

Belisle SE; Tisoncik JR; Korth MJ; Carter VS; Proll SC; Swayne DE; Pantin-Jackwood M; Tumpey TM; Katze MG. 2010. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 84(24):12576-88. [PubMed: 20926563]  [MGI Ref ID J:166538]

Berta T; Park CK; Xu ZZ; Xie RG; Liu T; Lu N; Liu YC; Ji RR. 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest 124(3):1173-86. [PubMed: 24531553]  [MGI Ref ID J:209726]

Bertok S; Wilson MR; Dorr AD; Dokpesi JO; O'Dea KP; Marczin N; Takata M. 2011. Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice. Am J Physiol Lung Cell Mol Physiol 300(5):L781-9. [PubMed: 21378027]  [MGI Ref ID J:174247]

Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. [PubMed: 18192488]  [MGI Ref ID J:134193]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Blaauboer SM; Gabrielle VD; Jin L. 2014. MPYS/STING-mediated TNF-alpha, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol 192(1):492-502. [PubMed: 24307739]  [MGI Ref ID J:207163]

Boone DL; Turer EE; Lee EG; Ahmad RC; Wheeler MT; Tsui C; Hurley P; Chien M; Chai S; Hitotsumatsu O; McNally E; Pickart C; Ma A. 2004. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5(10):1052-60. [PubMed: 15334086]  [MGI Ref ID J:92694]

Borges VM; Vandivier RW; McPhillips KA; Kench JA; Morimoto K; Groshong SD; Richens TR; Graham BB; Muldrow AM; Van Heule L; Henson PM; Janssen WJ. 2009. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol 297(4):L586-95. [PubMed: 19648283]  [MGI Ref ID J:154222]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Stachnick G; Castaneda D; Nayar J; Sriramarao P. 2001. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol 24(3):304-11. [PubMed: 11245629]  [MGI Ref ID J:114289]

Bruce AJ; Boling W; Kindy MS; Peschon J; Kraemer PJ; Carpenter MK; Holtsberg FW; Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2(7):788-94. [PubMed: 8673925]  [MGI Ref ID J:33864]

Bulua AC; Simon A; Maddipati R; Pelletier M; Park H; Kim KY; Sack MN; Kastner DL; Siegel RM. 2011. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208(3):519-33. [PubMed: 21282379]  [MGI Ref ID J:176847]

Calder CJ; Nicholson LB; Dick AD. 2005. A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol 175(10):6286-93. [PubMed: 16272279]  [MGI Ref ID J:119347]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Campbell LA; Nosaka T; Rosenfeld ME; Yaraei K; Kuo CC. 2005. Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice. Infect Immun 73(5):3164-5. [PubMed: 15845526]  [MGI Ref ID J:97619]

Campos-Neto A; Ovendale P; Bement T; Koppi TA; Fanslow WC; Rossi MA; Alderson MR. 1998. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 160(5):2037-41. [PubMed: 9498737]  [MGI Ref ID J:123032]

Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. [PubMed: 21641402]  [MGI Ref ID J:173471]

Cataisson C; Pearson AJ; Torgerson S; Nedospasov SA; Yuspa SH. 2005. Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo. J Immunol 174(3):1686-92. [PubMed: 15661932]  [MGI Ref ID J:96402]

Chandrasekharan UM; Siemionow M; Unsal M; Yang L; Poptic E; Bohn J; Ozer K; Zhou Z; Howe PH; Penn M; DiCorleto PE. 2007. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood 109(5):1938-44. [PubMed: 17068152]  [MGI Ref ID J:145363]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Chen H; Koupenova M; Yang D; Sume SS; Trackman PC; Ravid K. 2011. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-alpha signaling. Exp Hematol 39(5):525-30. [PubMed: 21320567]  [MGI Ref ID J:177966]

Chen LW; Egan L; Li ZW; Greten FR; Kagnoff MF; Karin M. 2003. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-81. [PubMed: 12692538]  [MGI Ref ID J:83313]

Chen MC; Mudge CS; Klumpp DJ. 2006. Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis. Am J Physiol Renal Physiol 291(4):F741-9. [PubMed: 16622179]  [MGI Ref ID J:144913]

Chen SE; Gerken E; Zhang Y; Zhan M; Mohan RK; Li AS; Reid MB; Li YP. 2005. Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle. Am J Physiol Cell Physiol 289(5):C1179-87. [PubMed: 16079187]  [MGI Ref ID J:104990]

Chen SE; Jin B; Li YP. 2007. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292(5):C1660-71. [PubMed: 17151142]  [MGI Ref ID J:125884]

Chiu H; Gardner CR; Dambach DM; Brittingham JA; Durham SK; Laskin JD; Laskin DL. 2003. Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense. Am J Physiol Gastrointest Liver Physiol 285(5):G959-66. [PubMed: 12842828]  [MGI Ref ID J:86545]

Choi S; Park YS; Koga T; Treloar A; Kim KC. 2011. TNF-alpha is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol 44(2):255-60. [PubMed: 20448050]  [MGI Ref ID J:183356]

Choksi S; Lin Y; Pobezinskaya Y; Chen L; Park C; Morgan M; Li T; Jitkaew S; Cao X; Kim YS; Kim HS; Levitt P; Shih G; Birre M; Deng CX; Liu ZG. 2011. A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2. Mol Cell 42(5):597-609. [PubMed: 21658601]  [MGI Ref ID J:173568]

Chopra M; Lang I; Salzmann S; Pachel C; Kraus S; Bauerlein CA; Brede C; Garrote AL; Mattenheimer K; Ritz M; Schwinn S; Graf C; Schafer V; Frantz S; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One 8(9):e75737. [PubMed: 24098720]  [MGI Ref ID J:207733]

Chopra M; Riedel SS; Biehl M; Krieger S; von Krosigk V; Bauerlein CA; Brede C; Jordan Garrote AL; Kraus S; Schafer V; Ritz M; Mattenheimer K; Degla A; Mottok A; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6):1296-303. [PubMed: 23385062]  [MGI Ref ID J:198326]

Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. [PubMed: 18931327]  [MGI Ref ID J:159269]

Cliffe LJ; Potten CS; Booth CE; Grencis RK. 2007. An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection. Infect Immun 75(4):1556-64. [PubMed: 17242061]  [MGI Ref ID J:119507]

Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol 9(10):2344-57. [PubMed: 17506816]  [MGI Ref ID J:148669]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Cowley SC; Sedgwick JD; Elkins KL. 2007. Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth. J Immunol 179(11):7709-19. [PubMed: 18025217]  [MGI Ref ID J:155094]

Crisostomo PR; Wang M; Herring CM; Markel TA; Meldrum KK; Lillemoe KD; Meldrum DR. 2007. Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1). J Mol Cell Cardiol 42(1):142-9. [PubMed: 17070836]  [MGI Ref ID J:119659]

Crowe CR; Chen K; Pociask DA; Alcorn JF; Krivich C; Enelow RI; Ross TM; Witztum JL; Kolls JK. 2009. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol 183(8):5301-10. [PubMed: 19783685]  [MGI Ref ID J:153826]

Cunha TM; Verri WA Jr; Silva JS; Poole S; Cunha FQ; Ferreira SH. 2005. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A 102(5):1755-60. [PubMed: 15665080]  [MGI Ref ID J:96111]

Cusson N; Oikemus S; Kilpatrick ED; Cunningham L; Kelliher M. 2002. The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 196(1):15-26. [PubMed: 12093867]  [MGI Ref ID J:120699]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

D'Mello C ; Le T ; Swain MG. 2009. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci 29(7):2089-102. [PubMed: 19228962]  [MGI Ref ID J:146590]

Dapito DH; Mencin A; Gwak GY; Pradere JP; Jang MK; Mederacke I; Caviglia JM; Khiabanian H; Adeyemi A; Bataller R; Lefkowitch JH; Bower M; Friedman R; Sartor RB; Rabadan R; Schwabe RF. 2012. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21(4):504-16. [PubMed: 22516259]  [MGI Ref ID J:189330]

De Paepe ME; Gundavarapu S; Tantravahi U; Pepperell JR; Haley SA; Luks FI; Mao Q. 2008. Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development. Am J Pathol 173(1):42-56. [PubMed: 18535181]  [MGI Ref ID J:137382]

Deepe GS Jr; Buesing WR. 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immunol 188(1):334-44. [PubMed: 22102723]  [MGI Ref ID J:180361]

Dela Pena A; Leclercq I; Field J; George J; Jones B; Farrell G. 2005. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 129(5):1663-74. [PubMed: 16285964]  [MGI Ref ID J:124937]

Di Giuseppe M; Gambelli F; Hoyle GW; Lungarella G; Studer SM; Richards T; Yousem S; McCurry K; Dauber J; Kaminski N; Leikauf G; Ortiz LA. 2009. Systemic inhibition of NF-kappaB activation protects from silicosis. PLoS One 4(5):e5689. [PubMed: 19479048]  [MGI Ref ID J:149316]

Dragomir AC; Sun R; Mishin V; Hall LB; Laskin JD; Laskin DL. 2012. Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicol Sci 127(2):609-19. [PubMed: 22461450]  [MGI Ref ID J:185729]

Drayton DL; Bonizzi G; Ying X; Liao S; Karin M; Ruddle NH. 2004. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol 173(10):6161-8. [PubMed: 15528353]  [MGI Ref ID J:94289]

Duerrschmid C; Crawford JR; Reineke E; Taffet GE; Trial J; Entman ML; Haudek SB. 2013. TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. J Mol Cell Cardiol 57:59-67. [PubMed: 23337087]  [MGI Ref ID J:213255]

Edelblum KL; Goettel JA; Koyama T; McElroy SJ; Yan F; Polk DB. 2008. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem 283(43):29485-94. [PubMed: 18713739]  [MGI Ref ID J:142557]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Elizur A; Adair-Kirk TL; Kelley DG; Griffin GL; Demello DE; Senior RM. 2008. Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine. Am J Respir Cell Mol Biol 38(1):8-15. [PubMed: 17673686]  [MGI Ref ID J:143000]

Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114(1):71-7. [PubMed: 10620118]  [MGI Ref ID J:127060]

Feng Y; Teitelbaum DH. 2012. Epidermal growth factor/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 302(2):G236-49. [PubMed: 22075779]  [MGI Ref ID J:183319]

Feng Y; Teitelbaum DH. 2013. Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J Physiol 591(Pt 15):3709-23. [PubMed: 23753529]  [MGI Ref ID J:212137]

Fenger C; Drojdahl N; Wirenfeldt M; Sylvest L; Jorgensen OS; Meldgaard M; Lambertsen KL; Finsen B. 2006. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia 54(6):591-605. [PubMed: 16927297]  [MGI Ref ID J:156117]

Fickert P; Thueringer A; Moustafa T; Silbert D; Gumhold J; Tsybrovskyy O; Lebofsky M; Jaeschke H; Denk H; Trauner M. 2010. The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice. Lab Invest 90(6):844-52. [PubMed: 20368698]  [MGI Ref ID J:160746]

Finsterbusch M; Voisin MB; Beyrau M; Williams TJ; Nourshargh S. 2014. Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. J Exp Med 211(7):1307-14. [PubMed: 24913232]  [MGI Ref ID J:214447]

Flaherty MP; Guo Y; Tiwari S; Rezazadeh A; Hunt G; Sanganalmath SK; Tang XL; Bolli R; Dawn B. 2008. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol 45(6):735-41. [PubMed: 18824172]  [MGI Ref ID J:143321]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

Fu YX; Huang G; Matsumoto M; Molina H; Chaplin DD. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc Natl Acad Sci U S A 94(11):5739-43. [PubMed: 9159143]  [MGI Ref ID J:78647]

Fujii T; Kitaura H; Kimura K; Hakami ZW; Takano-Yamamoto T. 2012. IL-4 inhibits TNF-alpha-mediated osteoclast formation by inhibition of RANKL expression in TNF-alpha-activated stromal cells and direct inhibition of TNF-alpha-activated osteoclast precursors via a T-cell-independent mechanism in vivo. Bone 51(4):771-80. [PubMed: 22776139]  [MGI Ref ID J:192396]

Gardner CR; Laskin JD; Dambach DM; Chiu H; Durham SK; Zhou P; Bruno M; Gerecke DR; Gordon MK; Laskin DL. 2003. Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators. Toxicol Appl Pharmacol 192(2):119-30. [PubMed: 14550746]  [MGI Ref ID J:132377]

Garlet GP; Cardoso CR; Campanelli AP; Ferreira BR; Avila-Campos MJ; Cunha FQ; Silva JS. 2007. The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 147(1):128-38. [PubMed: 17177972]  [MGI Ref ID J:116678]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Cruceta J; Graves BD; Einhorn TA. 2001. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169(3):285-94. [PubMed: 11455125]  [MGI Ref ID J:70467]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Tsay A; Fitch J; Barnes GL; Graves DT; Einhorn TA. 2003. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 18(9):1584-92. [PubMed: 12968667]  [MGI Ref ID J:111507]

Goluszko E; Deng C; Poussin MA; Christadoss P. 2002. Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis. J Neuroimmunol 122(1-2):85-93. [PubMed: 11777546]  [MGI Ref ID J:102961]

Gomez MI; Lee A; Reddy B; Muir A; Soong G; Pitt A; Cheung A; Prince A. 2004. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 10(8):842-8. [PubMed: 15247912]  [MGI Ref ID J:91608]

Goretsky T; Dirisina R; Sinh P; Mittal N; Managlia E; Williams DB; Posca D; Ryu H; Katzman RB; Barrett TA. 2012. p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD. Am J Pathol 181(4):1306-15. [PubMed: 22863952]  [MGI Ref ID J:188612]

Grdina DJ; Murley JS; Miller RC; Mauceri HJ; Sutton HG; Li JJ; Woloschak GE; Weichselbaum RR. 2013. A survivin-associated adaptive response in radiation therapy. Cancer Res 73(14):4418-28. [PubMed: 23651635]  [MGI Ref ID J:199011]

Greenfeld CR; Roby KF; Pepling ME; Babus JK; Terranova PF; Flaws JA. 2007. Tumor Necrosis Factor (TNF) Receptor Type 2 Is an Important Mediator of TNF alpha Function in the Mouse Ovary. Biol Reprod 76(2):224-31. [PubMed: 17065602]  [MGI Ref ID J:121169]

Guevara Patino JA; Ivanov VN; Lacy E; Elkon KB; Marino MW; Nikolic-Zugic J. 2000. TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. J Immunol 164(4):1689-94. [PubMed: 10657611]  [MGI Ref ID J:60398]

Guma M; Stepniak D; Shaked H; Spehlmann ME; Shenouda S; Cheroutre H; Vicente-Suarez I; Eckmann L; Kagnoff MF; Karin M. 2011. Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med 208(9):1889-900. [PubMed: 21825016]  [MGI Ref ID J:177595]

Guo G; Morrissey J; McCracken R; Tolley T; Liapis H; Klahr S. 2001. Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis. Am J Physiol Renal Physiol 280(5):F777-85. [PubMed: 11292619]  [MGI Ref ID J:69294]

Hanawa N; Shinohara M; Saberi B; Gaarde WA; Han D; Kaplowitz N. 2008. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283(20):13565-77. [PubMed: 18337250]  [MGI Ref ID J:137109]

Harrison-Findik DD; Klein E; Evans J; Gollan J. 2009. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-{alpha} signaling. Am J Physiol Gastrointest Liver Physiol 296(1):G112-8. [PubMed: 19008338]  [MGI Ref ID J:143085]

He P; Zhong Z; Lindholm K; Berning L; Lee W; Lemere C; Staufenbiel M; Li R; Shen Y. 2007. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol 178(5):829-41. [PubMed: 17724122]  [MGI Ref ID J:134832]

He S; Liang Y; Shao F; Wang X. 2011. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 108(50):20054-9. [PubMed: 22123964]  [MGI Ref ID J:180434]

Hildebrand F; Pape HC; Harwood P; Wittwer T; Krettek C; van Griensven M. 2004. Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents. Clin Exp Immunol 138(2):221-9. [PubMed: 15498030]  [MGI Ref ID J:93785]

Hill GR; Teshima T; Gerbitz A; Pan L; Cooke KR; Brinson YS; Crawford JM; Ferrara JL. 1999. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest 104(4):459-67. [PubMed: 10449438]  [MGI Ref ID J:115293]

Hill GR; Teshima T; Rebel VI; Krijanovski OI; Cooke KR; Brinson YS; Ferrara JL. 2000. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol 164(2):656-63. [PubMed: 10623807]  [MGI Ref ID J:59298]

Huang L; Zhang R; Wu J; Chen J; Grosjean F; Satlin LH; Klein JD; Sands JM; Striker GE; Tan J; Zheng F. 2011. Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-alpha and its receptor 1. Kidney Int 79(6):613-23. [PubMed: 21150875]  [MGI Ref ID J:186880]

Iizuka K; Chaplin DD; Wang Y; Wu Q; Pegg LE; Yokoyama WM; Fu YX. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci U S A 96(11):6336-40. [PubMed: 10339588]  [MGI Ref ID J:55470]

Ilg RC; Davies MH; Powers MR. 2005. Altered retinal neovascularization in TNF receptor-deficient mice. Curr Eye Res 30(11):1003-13. [PubMed: 16282134]  [MGI Ref ID J:104652]

Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJ; Bonde S; Kokaia Z; Jacobsen SE; Lindvall O. 2006. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26(38):9703-12. [PubMed: 16988041]  [MGI Ref ID J:112713]

Ismail N; Stevenson HL; Walker DH. 2006. Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infect Immun 74(3):1846-56. [PubMed: 16495559]  [MGI Ref ID J:107384]

Jessup HK; Brewer AW; Omori M; Rickel EA; Budelsky AL; Yoon BR; Ziegler SF; Comeau MR. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol 181(6):4311-9. [PubMed: 18768889]  [MGI Ref ID J:139079]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Ji R; Tian S; Lu HJ; Lu Q; Zheng Y; Wang X; Ding J; Li Q; Lu Q. 2013. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol 191(12):6165-77. [PubMed: 24244024]  [MGI Ref ID J:207107]

Johnson BL 3rd; Goetzman HS; Prakash PS; Caldwell CC. 2013. Mechanisms underlying mouse TNF-alpha stimulated neutrophil derived microparticle generation. Biochem Biophys Res Commun 437(4):591-6. [PubMed: 23850678]  [MGI Ref ID J:210776]

Jones MR; Simms BT; Lupa MM; Kogan MS; Mizgerd JP. 2005. Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 175(11):7530-5. [PubMed: 16301661]  [MGI Ref ID J:122167]

Jun JC; Kertesy S; Jones MB; Marinis JM; Cobb BA; Tigno-Aranjuez JT; Abbott DW. 2013. Innate immune-directed NF-kappaB signaling requires site-specific NEMO ubiquitination. Cell Rep 4(2):352-61. [PubMed: 23871670]  [MGI Ref ID J:202106]

Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. [PubMed: 12133972]  [MGI Ref ID J:120707]

Kanehiro A; Lahn M; Makela MJ; Dakhama A; Joetham A; Rha YH; Born W; Gelfand EW. 2002. Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells. J Immunol 169(8):4190-7. [PubMed: 12370348]  [MGI Ref ID J:120174]

Kaushal N; Ramesh V; Gozal D. 2012. TNF-alpha and temporal changes in sleep architecture in mice exposed to sleep fragmentation. PLoS One 7(9):e45610. [PubMed: 23029133]  [MGI Ref ID J:191991]

Keller C; Keller P; Giralt M; Hidalgo J; Pedersen BK. 2004. Exercise normalises overexpression of TNF-alpha in knockout mice. Biochem Biophys Res Commun 321(1):179-82. [PubMed: 15358232]  [MGI Ref ID J:91303]

Kim YK; Oh SY; Jeon SG; Park HW; Lee SY; Chun EY; Bang B; Lee HS; Oh MH; Kim YS; Kim JH; Gho YS; Cho SH; Min KU; Kim YY; Zhu Z. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 178(8):5375-82. [PubMed: 17404323]  [MGI Ref ID J:145264]

Kitaura H; Sands MS; Aya K; Zhou P; Hirayama T; Uthgenannt B; Wei S; Takeshita S; Novack DV; Silva MJ; Abu-Amer Y; Ross FP; Teitelbaum SL. 2004. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol 173(8):4838-46. [PubMed: 15470024]  [MGI Ref ID J:93717]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

Knight B; Yeoh GC; Husk KL; Ly T; Abraham LJ; Yu C; Rhim JA; Fausto N. 2000. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice J Exp Med 192(12):1809-18. [PubMed: 11120777]  [MGI Ref ID J:66448]

Kociok N; Radetzky S; Krohne TU; Gavranic C; Joussen AM. 2006. Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice. Invest Ophthalmol Vis Sci 47(11):5057-65. [PubMed: 17065527]  [MGI Ref ID J:123086]

Koni PA; Flavell RA. 1998. A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta. J Exp Med 187(12):1977-83. [PubMed: 9625757]  [MGI Ref ID J:110881]

Kostyk AG; Dahl KM; Wynes MW; Whittaker LA; Weiss DJ; Loi R; Riches DW. 2006. Regulation of Chemokine Expression by NaCl Occurs Independently of Cystic Fibrosis Transmembrane Conductance Regulator in Macrophages. Am J Pathol 169(1):12-20. [PubMed: 16816357]  [MGI Ref ID J:110175]

Kovalenko A; Kim JC; Kang TB; Rajput A; Bogdanov K; Dittrich-Breiholz O; Kracht M; Brenner O; Wallach D. 2009. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206(10):2161-77. [PubMed: 19720838]  [MGI Ref ID J:153779]

KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. [PubMed: 17242058]  [MGI Ref ID J:119508]

Kurrelmeyer KM; Michael LH; Baumgarten G; Taffet GE; Peschon JJ; Sivasubramanian N; Entman ML; Mann DL. 2000. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A 97(10):5456-61. [PubMed: 10779546]  [MGI Ref ID J:62223]

Kyo Y; Kato K; Park YS; Gajghate S; Umehara T; Lillehoj EP; Suzaki H; Kim KC. 2012. Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae. Am J Respir Cell Mol Biol 46(2):149-56. [PubMed: 22298528]  [MGI Ref ID J:191908]

Laing GD; Clissa PB; Theakston RD; Moura-da-Silva AM; Taylor MJ. 2003. Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis. Eur J Immunol 33(12):3458-63. [PubMed: 14635056]  [MGI Ref ID J:87138]

Lambertsen KL; Clausen BH; Babcock AA; Gregersen R; Fenger C; Nielsen HH; Haugaard LS; Wirenfeldt M; Nielsen M; Dagnaes-Hansen F; Bluethmann H; Faergeman NJ; Meldgaard M; Deierborg T; Finsen B. 2009. Microglia protect neurons against ischemia by synthesis of tumor necrosis factor. J Neurosci 29(5):1319-30. [PubMed: 19193879]  [MGI Ref ID J:155658]

Lammermann T; Afonso PV; Angermann BR; Wang JM; Kastenmuller W; Parent CA; Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498(7454):371-5. [PubMed: 23708969]  [MGI Ref ID J:198733]

Laskin DL; Chen L; Hankey PA; Laskin JD. 2010. Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol 88(2):373-82. [PubMed: 20453108]  [MGI Ref ID J:163944]

Lee LN; Dias P; Han D; Yoon S; Shea A; Zakharov V; Parham D; Sarawar SR. 2010. A mouse model of lethal synergism between influenza virus and Haemophilus influenzae. Am J Pathol 176(2):800-11. [PubMed: 20042666]  [MGI Ref ID J:156599]

Lehmann W; Edgar CM; Wang K; Cho TJ; Barnes GL; Kakar S; Graves DT; Rueger JM; Gerstenfeld LC; Einhorn TA. 2005. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone 36(2):300-10. [PubMed: 15780956]  [MGI Ref ID J:104852]

Leon LR; Dineen S; Blaha MD; Rodriguez-Fernandez M; Clarke DC. 2013. Attenuated thermoregulatory, metabolic, and liver acute phase protein response to heat stroke in TNF receptor knockout mice. Am J Physiol Regul Integr Comp Physiol 305(12):R1421-32. [PubMed: 24133099]  [MGI Ref ID J:208308]

Leon LR; White AA; Kluger MJ. 1998. Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice. Am J Physiol 275(1 Pt 2):R269-77. [PubMed: 9688988]  [MGI Ref ID J:48865]

Li B; Vincent A; Cates J; Brantley-Sieders DM; Polk DB; Young PP. 2009. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res 69(1):338-48. [PubMed: 19118019]  [MGI Ref ID J:143025]

Li CL; Jiang J; Fan YQ; Fu GS; Wang JA; Fan WM. 2009. Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice. Chin Med J (Engl) 122(5):566-70. [PubMed: 19323909]  [MGI Ref ID J:151019]

Liang SC; Nickerson-Nutter C; Pittman DD; Carrier Y; Goodwin DG; Shields KM; Lambert AJ; Schelling SH; Medley QG; Ma HL; Collins M; Dunussi-Joannopoulos K; Fouser LA. 2010. IL-22 induces an acute-phase response. J Immunol 185(9):5531-8. [PubMed: 20870942]  [MGI Ref ID J:165199]

Liao S; Ruddle NH. 2006. Synchrony of high endothelial venules and lymphatic vessels revealed by immunization. J Immunol 177(5):3369-79. [PubMed: 16920978]  [MGI Ref ID J:139499]

Lipke AB; Matute-Bello G; Herrero R; Wong VA; Mongovin SM; Martin TR. 2011. Death receptors mediate the adverse effects of febrile-range hyperthermia on the outcome of lipopolysaccharide-induced lung injury. Am J Physiol Lung Cell Mol Physiol 301(1):L60-70. [PubMed: 21515659]  [MGI Ref ID J:175952]

Liu JY; Brass DM; Hoyle GW; Brody AR. 1998. TNF-alpha receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am J Pathol 153(6):1839-47. [PubMed: 9846974]  [MGI Ref ID J:51349]

Lobito AA; Kimberley FC; Muppidi JR; Komarow H; Jackson AJ; Hull KM; Kastner DL; Screaton GR; Siegel RM. 2006. Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS). Blood 108(4):1320-7. [PubMed: 16684962]  [MGI Ref ID J:139197]

Lorenz RG; Chaplin DD; McDonald KG; McDonough JS; Newberry RD. 2003. Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin beta Receptor, and TNF Receptor I Function. J Immunol 170(11):5475-82. [PubMed: 12759424]  [MGI Ref ID J:83455]

Lu B; Lu Y; Moser AH; Shigenaga JK; Grunfeld C; Feingold KR. 2008. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 295(6):E1502-9. [PubMed: 18940942]  [MGI Ref ID J:144645]

Lu B; Sims PJ; Wiedmer T; Moser AH; Shigenaga JK; Grunfeld C; Feingold KR. 2007. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Biochim Biophys Acta 1771(9):1177-85. [PubMed: 17590392]  [MGI Ref ID J:127023]

Lucey EC; Keane J; Kuang PP; Snider GL; Goldstein RH. 2002. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest 82(1):79-85. [PubMed: 11796828]  [MGI Ref ID J:126680]

Lukacs-Kornek V; Malhotra D; Fletcher AL; Acton SE; Elpek KG; Tayalia P; Collier AR; Turley SJ. 2011. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol 12(11):1096-104. [PubMed: 21926986]  [MGI Ref ID J:177695]

Lundberg P; Welander P; Openshaw H; Nalbandian C; Edwards C; Moldawer L; Cantin E. 2003. A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice. J Virol 77(21):11661-73. [PubMed: 14557652]  [MGI Ref ID J:86189]

Luther SA; Lopez T; Bai W; Hanahan D; Cyster JG. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12(5):471-81. [PubMed: 10843380]  [MGI Ref ID J:110548]

Mandik-Nayak L; Huang G; Sheehan KC; Erikson J; Chaplin DD. 2001. Signaling Through TNF Receptor p55 in TNF-alpha-Deficient Mice Alters the CXCL13/CCL19/CCL21 Ratio in the Spleen and Induces Maturation and Migration of Anergic B Cells into the B Cell Follicle. J Immunol 167(4):1920-8. [PubMed: 11489971]  [MGI Ref ID J:70819]

Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 108(16):6567-72. [PubMed: 21464320]  [MGI Ref ID J:171365]

Mascia F; Lam G; Keith C; Garber C; Steinberg SM; Kohn E; Yuspa SH. 2013. Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci Transl Med 5(199):199ra110. [PubMed: 23966299]  [MGI Ref ID J:213463]

Matsumoto M; Fu YX; Molina H; Huang G; Kim J; Thomas DA; Nahm MH; Chaplin DD. 1997. Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. J Exp Med 186(12):1997-2004. [PubMed: 9396768]  [MGI Ref ID J:44877]

Matsumoto M; Mariathasan S; Nahm MH; Baranyay F; Peschon JJ; Chaplin DD. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271(5253):1289-91. [PubMed: 8638112]  [MGI Ref ID J:63530]

Mazzon E; Cuzzocrea S. 2008. Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress. Am J Physiol Gastrointest Liver Physiol 294(5):G1268-80. [PubMed: 18308862]  [MGI Ref ID J:136584]

McBride S; Hoebe K; Georgel P; Janssen E. 2006. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 177(9):6122-8. [PubMed: 17056539]  [MGI Ref ID J:140522]

McComb S; Cessford E; Alturki NA; Joseph J; Shutinoski B; Startek JB; Gamero AM; Mossman KL; Sad S. 2014. Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proc Natl Acad Sci U S A 111(31):E3206-13. [PubMed: 25049377]  [MGI Ref ID J:212237]

McComb S; Cheung HH; Korneluk RG; Wang S; Krishnan L; Sad S. 2012. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ 19(11):1791-801. [PubMed: 22576661]  [MGI Ref ID J:204788]

McElroy SJ; Prince LS; Weitkamp JH; Reese J; Slaughter JC; Polk DB. 2011. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 301(4):G656-66. [PubMed: 21737776]  [MGI Ref ID J:178021]

Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. [PubMed: 15514106]  [MGI Ref ID J:96316]

Meng Y; Beckett MA; Liang H; Mauceri HJ; van Rooijen N; Cohen KS; Weichselbaum RR. 2010. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res 70(4):1534-43. [PubMed: 20145121]  [MGI Ref ID J:157610]

Mizgerd JP; Lupa MM; Hjoberg J; Vallone JC; Warren HB; Butler JP; Silverman ES. 2004. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am J Physiol Lung Cell Mol Physiol 286(6):L1302-10. [PubMed: 14966082]  [MGI Ref ID J:108146]

Mizgerd JP; Peschon JJ; Doerschuk CM. 2000. Roles of tumor necrosis factor receptor signaling during murine escherichia coli pneumonia Am J Respir Cell Mol Biol 22(1):85-91. [PubMed: 10615069]  [MGI Ref ID J:59773]

Mizgerd JP; Spieker MR; Doerschuk CM. 2001. Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol 166(6):4042-8. [PubMed: 11238652]  [MGI Ref ID J:126652]

Monden Y; Kubota T; Inoue T; Tsutsumi T; Kawano S; Ide T; Tsutsui H; Sunagawa K. 2007. Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction. Am J Physiol Heart Circ Physiol 293(1):H743-53. [PubMed: 17416608]  [MGI Ref ID J:126031]

Morio LA; Chiu H; Sprowles KA; Zhou P; Heck DE; Gordon MK; Laskin DL. 2001. Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 172(1):44-51. [PubMed: 11264022]  [MGI Ref ID J:125470]

Moulin M; Anderton H; Voss AK; Thomas T; Wong WW; Bankovacki A; Feltham R; Chau D; Cook WD; Silke J; Vaux DL. 2012. IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J 31(7):1679-91. [PubMed: 22327219]  [MGI Ref ID J:182515]

Mounzer RH; Svendsen OS; Baluk P; Bergman CM; Padera TP; Wiig H; Jain RK; McDonald DM; Ruddle NH. 2010. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood 116(12):2173-82. [PubMed: 20566898]  [MGI Ref ID J:164499]

Nadeau S; Filali M; Zhang J; Kerr BJ; Rivest S; Soulet D; Iwakura Y; de Rivero Vaccari JP; Keane RW; Lacroix S. 2011. Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1{beta} and TNF: Implications for Neuropathic Pain. J Neurosci 31(35):12533-12542. [PubMed: 21880915]  [MGI Ref ID J:176222]

Nakazawa T; Nakazawa C; Matsubara A; Noda K; Hisatomi T; She H; Michaud N; Hafezi-Moghadam A; Miller JW; Benowitz LI. 2006. Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci 26(49):12633-41. [PubMed: 17151265]  [MGI Ref ID J:116761]

Nandakumar KS; Holmdahl R. 2006. Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18. [PubMed: 16688680]  [MGI Ref ID J:115066]

Neels JG; Badeanlou L; Hester KD; Samad F. 2009. Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis. J Biol Chem 284(31):20692-8. [PubMed: 19494115]  [MGI Ref ID J:153182]

Neels JG; Pandey M; Hotamisligil GS; Samad F. 2006. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol 168(2):435-44. [PubMed: 16436658]  [MGI Ref ID J:106303]

Newberry RD; McDonough JS; McDonald KG; Lorenz RG. 2002. Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytes. J Immunol 168(10):4988-97. [PubMed: 11994450]  [MGI Ref ID J:127286]

Newton K; Dugger DL; Wickliffe KE; Kapoor N; de Almagro MC; Vucic D; Komuves L; Ferrando RE; French DM; Webster J; Roose-Girma M; Warming S; Dixit VM. 2014. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science 343(6177):1357-60. [PubMed: 24557836]  [MGI Ref ID J:209137]

Ngo VN; Korner H; Gunn MD; Schmidt KN; Riminton DS; Cooper MD; Browning JL; Sedgwick JD; Cyster JG. 1999. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 189(2):403-12. [PubMed: 9892622]  [MGI Ref ID J:52941]

Nisoli E; Briscini L; Giordano A; Tonello C; Wiesbrock SM; Uysal KT; Cinti S; Carruba MO; Hotamisligil GS. 2000. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci U S A 97(14):8033-8. [PubMed: 10884431]  [MGI Ref ID J:126631]

Noti M; Corazza N; Tuffin G; Schoonjans K; Brunner T. 2010. Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner. FASEB J 24(5):1340-6. [PubMed: 20056718]  [MGI Ref ID J:162367]

Nowak M; Gaines GC; Rosenberg J; Minter R; Bahjat FR; Rectenwald J; MacKay SL; Edwards CK 3rd; Moldawer LL. 2000. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol 278(5):R1202-9. [PubMed: 10801288]  [MGI Ref ID J:114276]

Oberholzer A; Oberholzer C; Bahjat FR; Edwards CK 3rd; Moldawer LL. 2001. Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality. J Endotoxin Res 7(5):375-80. [PubMed: 11753206]  [MGI Ref ID J:117350]

Oikawa D; Akai R; Iwawaki T. 2010. Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes. FEBS Lett 584(5):1066-70. [PubMed: 20146926]  [MGI Ref ID J:157925]

Ortiz LA; Lasky J; Lungarella G; Cavarra E; Martorana P; Banks WA; Peschon JJ; Schmidts HL; Brody AR; Friedman M. 1999. Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20(4):825-33. [PubMed: 10101016]  [MGI Ref ID J:56008]

Page DM; Roberts EM; Peschon JJ; Hedrick SM. 1998. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol 160(1):120-33. [PubMed: 9551964]  [MGI Ref ID J:110946]

Pamir N; McMillen TS; Kaiyala KJ; Schwartz MW; LeBoeuf RC. 2009. Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status. Endocrinology 150(9):4124-34. [PubMed: 19477937]  [MGI Ref ID J:158146]

Pan W; Kastin AJ. 2002. TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice. Exp Neurol 174(2):193-200. [PubMed: 11922661]  [MGI Ref ID J:75855]

Pan W; Yu C; Hsuchou H; Zhang Y; Kastin AJ. 2008. Neuroinflammation facilitates LIF entry into brain: role of TNF. Am J Physiol Cell Physiol 294(6):C1436-42. [PubMed: 18385284]  [MGI Ref ID J:136622]

Panthel K; Faller G; Haas R. 2003. Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity. Infect Immun 71(2):794-800. [PubMed: 12540559]  [MGI Ref ID J:81703]

Park JM; Ng VH; Maeda S; Rest RF; Karin M. 2004. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 200(12):1647-55. [PubMed: 15611291]  [MGI Ref ID J:95336]

Park SH; Park-Min KH; Chen J; Hu X; Ivashkiv LB. 2011. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol 12(7):607-15. [PubMed: 21602809]  [MGI Ref ID J:174318]

Pronk CJ; Veiby OP; Bryder D; Jacobsen SE. 2011. Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. J Exp Med 208(8):1563-70. [PubMed: 21768269]  [MGI Ref ID J:177605]

Pryhuber GS; Huyck HL; Baggs R; Oberdorster G; Finkelstein JN. 2003. Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice. Toxicol Sci 72(1):150-7. [PubMed: 12604844]  [MGI Ref ID J:126224]

Pryhuber GS; O'Brien DP; Baggs R; Phipps R; Huyck H; Sanz I; Nahm MH. 2000. Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. Am J Physiol Lung Cell Mol Physiol 278(5):L1082-90. [PubMed: 10781441]  [MGI Ref ID J:62347]

Qin L; Wu X; Block ML; Liu Y; Breese GR; Hong JS; Knapp DJ; Crews FT. 2007. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55(5):453-62. [PubMed: 17203472]  [MGI Ref ID J:156104]

Quinton LJ; Jones MR; Robson BE; Mizgerd JP. 2009. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun 77(6):2417-26. [PubMed: 19289507]  [MGI Ref ID J:149372]

Rasmussen CA; Pace JL; Banerjee S; Phillips TA; Hunt JS. 1999. Trophoblastic cell lines generated from tumour necrosis factor receptor-deficient mice reveal specific functions for the two tumour necrosis factor receptors. Placenta 20(2-3):213-22. [PubMed: 10195744]  [MGI Ref ID J:54170]

Rezzoug F; Huang Y; Tanner MK; Wysoczynski M; Schanie CL; Chilton PM; Ratajczak MZ; Fugier-Vivier IJ; Ildstad ST. 2008. TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function. J Immunol 180(1):49-57. [PubMed: 18097003]  [MGI Ref ID J:130880]

Riehl TE; Newberry RD; Lorenz RG; Stenson WF. 2004. TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. Am J Physiol Gastrointest Liver Physiol 286(1):G166-73. [PubMed: 14525729]  [MGI Ref ID J:87602]

Roby KF; Son DS; Terranova PF. 1999. Alterations of events related to ovarian function in tumor necrosis factor receptor type I knockout mice. Biol Reprod 61(6):1616-21. [PubMed: 10570011]  [MGI Ref ID J:58728]

Rosenfeld ME; Prichard L; Shiojiri N; Fausto N. 2000. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. Am J Pathol 156(3):997-1007. [PubMed: 10702415]  [MGI Ref ID J:60742]

Rountree RB; Willis CR; Dinh H; Blumberg H; Bailey K; Dean C Jr; Peschon JJ; Holland PM. 2010. RIP4 regulates epidermal differentiation and cutaneous inflammation. J Invest Dermatol 130(1):102-12. [PubMed: 19626033]  [MGI Ref ID J:159585]

Rudick CN; Bryce PJ; Guichelaar LA; Berry RE; Klumpp DJ. 2008. Mast cell-derived histamine mediates cystitis pain. PLoS ONE 3(5):e2096. [PubMed: 18461160]  [MGI Ref ID J:136218]

Russo BC; Horzempa J; O'Dee DM; Schmitt DM; Brown MJ; Carlson PE Jr; Xavier RJ; Nau GJ. 2011. A Francisella tularensis Locus Required for Spermine Responsiveness Is Necessary for Virulence. Infect Immun 79(9):3665-76. [PubMed: 21670171]  [MGI Ref ID J:175717]

Salomon R; Hoffmann E; Webster RG. 2007. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A 104(30):12479-81. [PubMed: 17640882]  [MGI Ref ID J:123301]

Sam H; Su Z; Stevenson MM. 1999. Deficiency in tumor necrosis factor alpha activity does not impair early protective Th1 responses against blood-stage malaria. Infect Immun 67(5):2660-4. [PubMed: 10225939]  [MGI Ref ID J:55976]

Samad F; Uysal KT; Wiesbrock SM; Pandey M; Hotamisligil GS; Loskutoff DJ. 1999. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A 96(12):6902-7. [PubMed: 10359811]  [MGI Ref ID J:55722]

Schreyer SA; Chua SC Jr; LeBoeuf RC. 1998. Obesity and diabetes in TNF-alpha receptor- deficient mice. J Clin Invest 102(2):402-11. [PubMed: 9664082]  [MGI Ref ID J:48696]

Schreyer SA; Peschon JJ; LeBoeuf RC. 1996. Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55. J Biol Chem 271(42):26174-8. [PubMed: 8824264]  [MGI Ref ID J:110801]

Schworer SA; Smirnova II; Kurbatova I; Bagina U; Churova M; Fowler T; Roy AL; Degterev A; Poltorak A. 2014. Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. J Biol Chem 289(20):14422-33. [PubMed: 24706750]  [MGI Ref ID J:214121]

Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124]  [MGI Ref ID J:118778]

Sethi JK; Xu H; Uysal KT; Wiesbrock SM; Scheja L; Hotamisligil GS. 2000. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Lett 469(1):77-82. [PubMed: 10708760]  [MGI Ref ID J:60998]

Shukla M; Yang S; Milla C; Panoskaltsis-Mortari A; Blazar BR; Haddad IY. 2005. Absence of host tumor necrosis factor receptor 1 attenuates manifestations of idiopathic pneumonia syndrome. Am J Physiol Lung Cell Mol Physiol 288(5):L942-9. [PubMed: 15608149]  [MGI Ref ID J:115461]

Simeonova PP; Gallucci RM; Hulderman T; Wilson R; Kommineni C; Rao M; Luster MI. 2001. The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. Toxicol Appl Pharmacol 177(2):112-20. [PubMed: 11740910]  [MGI Ref ID J:125461]

Simon A; Park H; Maddipati R; Lobito AA; Bulua AC; Jackson AJ; Chae JJ; Ettinger R; de Koning HD; Cruz AC; Kastner DL; Komarow H; Siegel RM. 2010. Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A 107(21):9801-6. [PubMed: 20457915]  [MGI Ref ID J:160543]

Smith JR; Hart PH; Coster DJ; Williams KA. 1998. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 39(3):658-61. [PubMed: 9501881]  [MGI Ref ID J:46231]

Smith S; Skerrett SJ; Chi EY; Jonas M; Mohler K; Wilson CB. 1998. The locus of tumor necrosis factor-alpha action in lung inflammation. Am J Respir Cell Mol Biol 19(6):881-91. [PubMed: 9843922]  [MGI Ref ID J:52096]

Smoak KA; Aloor JJ; Madenspacher J; Merrick BA; Collins JB; Zhu X; Cavigiolio G; Oda MN; Parks JS; Fessler MB. 2010. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metab 11(6):493-502. [PubMed: 20519121]  [MGI Ref ID J:160911]

Soloviova K; Puliaiev M; Haas M; Via CS. 2013. In Vivo Maturation of Allo-Specific CD8 CTL and Prevention of Lupus-like Graft-versus-Host Disease Is Critically Dependent on T Cell Signaling through the TNF p75 Receptor But Not the TNF p55 Receptor. J Immunol 190(9):4562-72. [PubMed: 23526821]  [MGI Ref ID J:195525]

Sriram K; Matheson JM; Benkovic SA; Miller DB; Luster MI; O'Callaghan JP. 2006. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB J 20(6):670-82. [PubMed: 16581975]  [MGI Ref ID J:107903]

Sriram K; Matheson JM; Benkovic SA; Miller DB; Luster MI; O'Callaghan JP. 2002. Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J 16(11):1474-6. [PubMed: 12205053]  [MGI Ref ID J:78637]

Steinberg GR; Michell BJ; van Denderen BJ; Watt MJ; Carey AL; Fam BC; Andrikopoulos S; Proietto J; Gorgun CZ; Carling D; Hotamisligil GS; Febbraio MA; Kay TW; Kemp BE. 2006. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab 4(6):465-74. [PubMed: 17141630]  [MGI Ref ID J:129774]

Strutt TM; McKinstry KK; Dibble JP; Winchell C; Kuang Y; Curtis JD; Huston G; Dutton RW; Swain SL. 2010. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16(5):558-64, 1p following 564. [PubMed: 20436484]  [MGI Ref ID J:160609]

Sullivan PG; Bruce-Keller AJ; Rabchevsky AG; Christakos S; Clair DK; Mattson MP; Scheff SW. 1999. Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci 19(15):6248-56. [PubMed: 10414954]  [MGI Ref ID J:110921]

Sumagin R; Kuebel JM; Sarelius IH. 2011. Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1. Am J Physiol Cell Physiol 301(4):C804-13. [PubMed: 21653902]  [MGI Ref ID J:177623]

Suresh M; Gao X; Fischer C; Miller NE; Tewari K. 2004. Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection. J Virol 78(8):3906-18. [PubMed: 15047807]  [MGI Ref ID J:89104]

Suvannavejh GC; Lee HO; Padilla J; Dal Canto MC; Barrett TA; Miller SD. 2000. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis Cell Immunol 205(1):24-33. [PubMed: 11078604]  [MGI Ref ID J:65846]

Szretter KJ; Gangappa S; Lu X; Smith C; Shieh WJ; Zaki SR; Sambhara S; Tumpey TM; Katz JM. 2007. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol 81(6):2736-44. [PubMed: 17182684]  [MGI Ref ID J:153325]

Tang W; Lu Y; Tian QY; Zhang Y; Guo FJ; Liu GY; Syed NM; Lai Y; Lin EA; Kong L; Su J; Yin F; Ding AH; Zanin-Zhorov A; Dustin ML; Tao J; Craft J; Yin Z; Feng JQ; Abramson SB; Yu XP; Liu CJ. 2011. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332(6028):478-84. [PubMed: 21393509]  [MGI Ref ID J:171041]

Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157]  [MGI Ref ID J:106721]

Taylor RT; Lugering A; Newell KA; Williams IR. 2004. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol 173(12):7183-9. [PubMed: 15585839]  [MGI Ref ID J:94865]

Teh HS; Seebaran A; Teh SJ. 2000. TNF receptor 2-deficient CD8 T cells are resistant to Fas/Fas ligand-induced cell death. J Immunol 165(9):4814-21. [PubMed: 11046004]  [MGI Ref ID J:118924]

Theiss AL; Simmons JG; Jobin C; Lund PK. 2005. Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 280(43):36099-109. [PubMed: 16141211]  [MGI Ref ID J:102699]

Toda K; Hayashi Y; Saibara T. 2010. Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice. Biochim Biophys Acta 1801(6):655-64. [PubMed: 20226875]  [MGI Ref ID J:165383]

Tomita K; Tamiya G; Ando S; Ohsumi K; Chiyo T; Mizutani A; Kitamura N; Toda K; Kaneko T; Horie Y; Han JY; Kato S; Shimoda M; Oike Y; Tomizawa M; Makino S; Ohkura T; Saito H; Kumagai N; Nagata H; Ishii H; Hibi T. 2006. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 55(3):415-24. [PubMed: 16174657]  [MGI Ref ID J:135782]

Torrado E; Adusumilli S; Fraga AG; Small PL; Castro AG; Pedrosa J. 2007. Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection. Infect Immun 75(8):3979-88. [PubMed: 17517872]  [MGI Ref ID J:123376]

Unterholzner L; Keating SE; Baran M; Horan KA; Jensen SB; Sharma S; Sirois CM; Jin T; Latz E; Xiao TS; Fitzgerald KA; Paludan SR; Bowie AG. 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11(11):997-1004. [PubMed: 20890285]  [MGI Ref ID J:166541]

Uysal KT; Wiesbrock SM; Hotamisligil GS. 1998. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology 139(12):4832-8. [PubMed: 9832419]  [MGI Ref ID J:110666]

Uysal KT; Wiesbrock SM; Marino MW; Hotamisligil GS. 1997. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389(6651):610-4. [PubMed: 9335502]  [MGI Ref ID J:43280]

Vaira S; Alhawagri M; Anwisye I; Kitaura H; Faccio R; Novack DV. 2008. RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest 118(6):2088-97. [PubMed: 18464930]  [MGI Ref ID J:137682]

Valerio A; Cardile A; Cozzi V; Bracale R; Tedesco L; Pisconti A; Palomba L; Cantoni O; Clementi E; Moncada S; Carruba MO; Nisoli E. 2006. TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest 116(10):2791-8. [PubMed: 16981010]  [MGI Ref ID J:115008]

Van Hauwermeiren F; Armaka M; Karagianni N; Kranidioti K; Vandenbroucke RE; Loges S; Van Roy M; Staelens J; Puimege L; Palagani A; Berghe WV; Victoratos P; Carmeliet P; Libert C; Kollias G. 2013. Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest 123(6):2590-603. [PubMed: 23676465]  [MGI Ref ID J:210950]

Varanasi V; Avanesyan L; Schumann DM; Chervonsky AV. 2012. Cytotoxic mechanisms employed by mouse t cells to destroy pancreatic beta-cells. Diabetes 61(11):2862-70. [PubMed: 22773667]  [MGI Ref ID J:190161]

Vasudevan NT; Mohan ML; Gupta MK; Martelli EE; Hussain AK; Qin Y; Chandrasekharan UM; Young D; Feldman AM; Sen S; Dorn GW 2nd; Dicorleto PE; Naga Prasad SV. 2013. Gbetagamma-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor alpha-induced cardiac beta-adrenergic receptor dysfunction. Circulation 128(4):377-87. [PubMed: 23785004]  [MGI Ref ID J:218735]

Vazquez-Torres A; Fantuzzi G; Edwards CK 3rd; Dinarello CA; Fang FC. 2001. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc Natl Acad Sci U S A 98(5):2561-5. [PubMed: 11226278]  [MGI Ref ID J:126397]

Vicente R; Coma M; Busquets S; Moore-Carrasco R; Lopez-Soriano FJ; Argiles JM; Felipe A. 2004. The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways. FEBS Lett 572(1-3):189-94. [PubMed: 15304346]  [MGI Ref ID J:119328]

Villar SR; Ronco MT; Fernandez Bussy R; Roggero E; Lepletier A; Manarin R; Savino W; Perez AR; Bottasso O. 2013. Tumor necrosis factor-alpha regulates glucocorticoid synthesis in the adrenal glands of Trypanosoma cruzi acutely-infected mice. the role of TNF-R1. PLoS One 8(5):e63814. [PubMed: 23717489]  [MGI Ref ID J:200836]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

Volejnikova S; Marks SC Jr; Graves DT. 2002. Tumor necrosis factor modulates apoptosis of monocytes in areas of developmentally regulated bone remodeling. J Bone Miner Res 17(6):991-7. [PubMed: 12054175]  [MGI Ref ID J:112343]

Volk A; Li J; Xin J; You D; Zhang J; Liu X; Xiao Y; Breslin P; Li Z; Wei W; Schmidt R; Li X; Zhang Z; Kuo PC; Nand S; Zhang J; Chen J; Zhang J. 2014. Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML. J Exp Med 211(6):1093-108. [PubMed: 24842373]  [MGI Ref ID J:213732]

Waldner MJ; Wirtz S; Jefremow A; Warntjen M; Neufert C; Atreya R; Becker C; Weigmann B; Vieth M; Rose-John S; Neurath MF. 2010. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med 207(13):2855-68. [PubMed: 21098094]  [MGI Ref ID J:176868]

Wang M; Crisostomo PR; Markel TA; Wang Y; Meldrum DR. 2008. Mechanisms of sex differences in TNFR2-mediated cardioprotection. Circulation 118(14 Suppl):S38-45. [PubMed: 18824767]  [MGI Ref ID J:158041]

Wang Q; Chang L; Rowan MJ; Anwyl R. 2007. Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus. Neuroscience 144(1):110-8. [PubMed: 17055173]  [MGI Ref ID J:117954]

Wang Q; Wu J; Rowan MJ; Anwyl R. 2005. Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor. Eur J Neurosci 22(11):2827-32. [PubMed: 16324117]  [MGI Ref ID J:104311]

Wang Y; Huang G; Wang J; Molina H; Chaplin DD; Fu YX. 2000. Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin Eur J Immunol 30(8):2226-34. [PubMed: 10940914]  [MGI Ref ID J:63948]

Wang Y; Wang J; Sun Y; Wu Q; Fu YX. 2001. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells J Immunol 166(1):330-7. [PubMed: 11123309]  [MGI Ref ID J:66397]

Warren GL; Hulderman T; Jensen N; McKinstry M; Mishra M; Luster MI; Simeonova PP. 2002. Physiological role of tumor necrosis factor alpha in traumatic muscle injury. FASEB J 16(12):1630-2. [PubMed: 12207010]  [MGI Ref ID J:119897]

Wei S; Kitaura H; Zhou P; Ross FP; Teitelbaum SL. 2005. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest 115(2):282-90. [PubMed: 15668736]  [MGI Ref ID J:95955]

Wiede F; Roomberg A; Cretney E; Lechner A; Fromm P; Wren L; Smyth MJ; Korner H. 2009. Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice. J Leukoc Biol 85(1):108-16. [PubMed: 18948547]  [MGI Ref ID J:144623]

Williams JM; Duckworth CA; Watson AJ; Frey MR; Miguel JC; Burkitt MD; Sutton R; Hughes KR; Hall LJ; Caamano JH; Campbell BJ; Pritchard DM. 2013. A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Dis Model Mech 6(6):1388-99. [PubMed: 24046352]  [MGI Ref ID J:205156]

Wilson MR; Goddard ME; O'Dea KP; Choudhury S; Takata M. 2007. Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. Am J Physiol Lung Cell Mol Physiol 293(1):L60-8. [PubMed: 17435079]  [MGI Ref ID J:143836]

Woodfin A; Voisin MB; Imhof BA; Dejana E; Engelhardt B; Nourshargh S. 2009. Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood 113(24):6246-57. [PubMed: 19211506]  [MGI Ref ID J:149379]

Woodworth JS; Wu Y; Behar SM. 2008. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol 181(12):8595-603. [PubMed: 19050279]  [MGI Ref ID J:142057]

Worthington JJ; Samuelson LC; Grencis RK; McLaughlin JT. 2013. Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion. PLoS Pathog 9(1):e1003122. [PubMed: 23349631]  [MGI Ref ID J:195851]

Wright TW; Pryhuber GS; Chess PR; Wang Z; Notter RH; Gigliotti F. 2004. TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia. J Immunol 172(4):2511-21. [PubMed: 14764724]  [MGI Ref ID J:132425]

Xiao Y; Li H; Zhang J; Volk A; Zhang S; Wei W; Zhang S; Breslin P; Zhang J. 2011. TNF-alpha/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood 118(23):6057-67. [PubMed: 21989986]  [MGI Ref ID J:179087]

Xu ZZ; Zhang L; Liu T; Park JY; Berta T; Yang R; Serhan CN; Ji RR. 2010. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med 16(5):592-7, 1p following 597. [PubMed: 20383154]  [MGI Ref ID J:161538]

Yamada Y; Kirillova I; Peschon JJ; Fausto N. 1997. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A 94(4):1441-6. [PubMed: 9037072]  [MGI Ref ID J:38601]

Yamada Y; Webber EM; Kirillova I; Peschon JJ; Fausto N. 1998. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology 28(4):959-70. [PubMed: 9755232]  [MGI Ref ID J:106554]

Yang G; Badeanlou L; Bielawski J; Roberts AJ; Hannun YA; Samad F. 2009. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab 297(1):E211-24. [PubMed: 19435851]  [MGI Ref ID J:151166]

Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465]  [MGI Ref ID J:127080]

Zakharova M; Ziegler HK. 2005. Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. J Immunol 175(8):5024-33. [PubMed: 16210605]  [MGI Ref ID J:119097]

Zhan M; Jin B; Chen SE; Reecy JM; Li YP. 2007. TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38 MAPK and myogenesis. J Cell Sci 120(Pt 4):692-701. [PubMed: 17264149]  [MGI Ref ID J:120759]

Zhan Y; Cheers C. 1998. Control of IL-12 and IFN-gamma production in response to live or dead bacteria by TNF and other factors. J Immunol 161(3):1447-53. [PubMed: 9686610]  [MGI Ref ID J:112078]

Zhang B; Hirahashi J; Cullere X; Mayadas TN. 2003. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem 278(31):28443-54. [PubMed: 12736263]  [MGI Ref ID J:120441]

Zhang L; Peppel K; Sivashanmugam P; Orman ES; Brian L; Exum ST; Freedman NJ. 2007. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 27(5):1087-94. [PubMed: 17442899]  [MGI Ref ID J:128059]

Zhang X; Sejas DP; Qiu Y; Williams DA; Pang Q. 2007. Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci 120(Pt 9):1572-83. [PubMed: 17405815]  [MGI Ref ID J:124053]

Zhao J; Kim KD; Yang X; Auh S; Fu YX; Tang H. 2008. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A 105(21):7528-33. [PubMed: 18490660]  [MGI Ref ID J:136311]

Zhao Y; Wilson D; Matthews S; Yap GS. 2007. Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling. Infect Immun 75(10):4799-803. [PubMed: 17682046]  [MGI Ref ID J:125278]

Zheng L; Fisher G; Miller RE; Peschon J; Lynch DH; Lenardo MJ. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377(6547):348-51. [PubMed: 7566090]  [MGI Ref ID J:28944]

Zhou H; Lapointe BM; Clark SR; Zbytnuik L; Kubes P. 2006. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol 177(11):8103-10. [PubMed: 17114485]  [MGI Ref ID J:140683]

Zhou J; Zhang M; Atherton SS. 2007. Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci 48(4):1691-700. [PubMed: 17389501]  [MGI Ref ID J:123256]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $205.90Female or MaleHomozygous for Tnfrsf1atm1Imx  
Price per Pair (US dollars $)Pair Genotype
$411.80Homozygous for Tnfrsf1atm1Imx x Homozygous for Tnfrsf1atm1Imx  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $267.70Female or MaleHomozygous for Tnfrsf1atm1Imx  
Price per Pair (US dollars $)Pair Genotype
$535.40Homozygous for Tnfrsf1atm1Imx x Homozygous for Tnfrsf1atm1Imx  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.