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Strain Name:

C57BL/6-Tnfrsf1atm1Imx/J

Stock Number:

003242

Availability:

Repository- Live

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General Terms and Conditions

Former Name      Tnfr1    (Changed: 15-DEC-04 )
Genes & Alleles   Tnfrsf1a;   Tnfrsf1atm1Imx;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Targeted Mutation
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Donating Investigator Jacques Peschon,   Amgen
GenerationN1F15N1F3 (08-JAN-08)

Strain Description
Mice homozygous for the Tnfrsf1atm1Imx targeted mutation (formerly Tnfr1tm1Imx, p55 deficient) show defects in resistance to intracellular pathogens and are resistant to the lethal effects of LPS administration in conjunction with D-galactosamine. Pulmonary inflammatory responses are diminished in p55 deficient mice. There are also defects in Peyer's patch development, splenic architecture, formation of germinal centers, and liver regeneration. TNFRSF1 deficient mice display increased susceptibility to atherosclerosis when maintained on a high fat diet.

Related Disease (OMIM) Terms

NOTPeriodic Fever, Familial, Autosomal Dominant
Mammalian Phenotype Terms assigned by genotype

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        C57BL/6-Tnfrsf1atm1Imx
  • immune system phenotype
  • decreased inflammatory response (MGI Ref ID J:45147)
    • decreased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control
  • decreased susceptibility to endotoxin shock (MGI Ref ID J:45147)
    • exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS)
  • increased circulating tumor necrosis factor level (MGI Ref ID J:45147)
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered
  • increased susceptibility to bacterial infection (MGI Ref ID J:45147)
    • 100% of mice succumb to a sublethal dose of Listeria monocytogenes 4 days post-infection
  • homeostasis/metabolism phenotype
  • increased circulating tumor necrosis factor level (MGI Ref ID J:45147)
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal immune system physiology (MGI Ref ID J:45147)

Gene & Allele Details

Allele Symbol Tnfrsf1atm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Common Name(s) TNF-alpha-R1; TNFR1-; TNFR-; TNFRI-; Tnfrsf1atm1Imx; p55 KO; p55-;
Mutation Made By Jacques Peschon,   Amgen
Strain of OriginC57BL/6
Gene Symbol and Name Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
Chromosome 6
Gene Common Name(s) CD120a; FPF; MGC19588; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR1; TNFR55; TNFR60; TNFRI; TNFRp55; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. [MGI Ref ID J:110548] [MGI Ref ID J:45147]

Control Information

  Allele   Control
 Tnfrsf1atm1Imx  000664 C57BL/6J
 
  Considerations for Choosing Controls

Genotyping Protocols

Tnfrsf1atm1Imx

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying   Tnfrsf1atm1Imx allele
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
View Strains carrying   Tnfrsf1atm1Imx     (2 strains)

Strains carrying other alleles of Tnfrsf1a
002818   B6.129-Tnfrsf1atm1Mak/J
View Strains carrying other alleles of Tnfrsf1a     (1 strain)

Animal Health Reports

Room Number           AX12

Research Applications

This mouse can be used to support research in many areas including:

Tnfrsf1atm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Inflammation

References

Selected Reference(s)

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Price and Supply Information

Strain Name: C57BL/6-Tnfrsf1atm1Imx/J
Stock Number: 003242

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Induced Mutant Resource Colony collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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