Strain Name:

B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J

Stock Number:

003243

Availability:

Level 4

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
GenerationB6N4F?+26 (11-JAN-08)
 
Donating Investigator Jacques Peschon,   Amgen

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for both the Tnfrsf1atm1Imx and Tnfrsf1btm1Imx targeted mutations (p55 and p75 deficient) are viable and fertile. Double homozygous mutant mice fail to bind TNF. Thymus, spleen, and other lymphoid tissue are normal, indicating that TNF is not required for normal development of these organs.

Development
The double mutant mice lacking both Tnfrsf1a (p55) and Tnfrsf1b (p75) were generated by intercrossing the singly deficient mice. According to the donating investigator, the Tnfrsf1b mutation (129S7/SvEvBrd background) was moved onto the Tnfrsf1a background (C57BL/6) by successive backcrosses to the latter (to N4). For the Tnfrsf1a mutation, a PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). For the Tnfrsf1b mutation, a PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tnfrsf1atm1Imx allele
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
003242   C57BL/6-Tnfrsf1atm1Imx/J
View Strains carrying   Tnfrsf1atm1Imx     (2 strains)

Strains carrying   Tnfrsf1btm1Imx allele
003246   B6.129S7-Tnfrsf1btm1Imx/J
View Strains carrying   Tnfrsf1btm1Imx     (1 strain)

Strains carrying other alleles of Tnfrsf1a
002818   B6.129-Tnfrsf1atm1Mak/J
View Strains carrying other alleles of Tnfrsf1a     (1 strain)

Strains carrying other alleles of Tnfrsf1b
002620   B6.129S2-Tnfrsf1btm1Mwm/J
View Strains carrying other alleles of Tnfrsf1b     (1 strain)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

Tnfrsf1atm1Imx/Tnfrsf1atm1Imx Tnfrsf1btm1Imx/Tnfrsf1btm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • decreased inflammatory response (MGI Ref ID J:45147)
    • M. faeni- induced neutrophil accumulation in the lung is decreased as compared to control, however monocyte and lymphocyte levels are comparable to control
  • decreased susceptibility to endotoxin shock (MGI Ref ID J:45147)
    • exhibits resistance to a lethal LPS dose plus hepatoxin D-gal (increases sensitivity to LPS)
  • increased circulating tumor necrosis factor level (MGI Ref ID J:45147)
    • two hours post lipopolysaccharide (LPS) challenge serum levels are 15-20 fold higher than controls, however, TNF kinetics and activity are not altered
  • increased susceptibility to bacterial infection (MGI Ref ID J:58851)
    • mice have 3 log greater bacterial penetration of the dental pulp eight days after experimental bacterial infection
  • osteomyelitis (MGI Ref ID J:58851)
    • osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp
    • the osteolytic lesions continue to be larger for at least 38 days after innoculation
  • homeostasis/metabolism phenotype
  • increased circulating tumor necrosis factor level (MGI Ref ID J:45147)
    • two hours post lipopolysaccharide (LPS) challenge serum levels are 15-20 fold higher than controls, however, TNF kinetics and activity are not altered
  • cellular phenotype
  • necrosis (MGI Ref ID J:58851)
    • mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation
    • complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation
  • skeleton phenotype
  • increased bone resorption (MGI Ref ID J:58851)
    • there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp
    • osteoclast activity of the molars is almost 2-fold higher than in wild-types 7 days after bacterial inoculation
  • osteomyelitis (MGI Ref ID J:58851)
    • osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp
    • the osteolytic lesions continue to be larger for at least 38 days after innoculation

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Parkinson's Disease (resistance to MPTP)

Tnfrsf1atm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Inflammation

Tnfrsf1btm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol Tnfrsf1atm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Common Name(s) TNF-alpha-R1; TNFR1-; TNFR-; TNFRI-; Tnfrsf1atm1Imx; p55 KO; p55-;
Mutation Made By Jacques Peschon,   Amgen
Strain of OriginC57BL/6
Gene Symbol and Name Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
Chromosome 6
Gene Common Name(s) CD120a; FPF; MGC19588; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR1; TNFR55; TNFR60; TNFRI; TNFRp55; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. [MGI Ref ID J:110548] [MGI Ref ID J:45147]
 
Allele Symbol Tnfrsf1btm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Common Name(s) TNFR2-; TNFRII-; TNFbeta ko; Tnfrsf1btm1Imx; p75 KO; p75-;
Mutation Made By Jacques Peschon,   Amgen
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Tnfrsf1b, tumor necrosis factor receptor superfamily, member 1b
Chromosome 4
Gene Common Name(s) CD120b; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-alphaR2; TNFBR; TNFR1B; TNFR2; TNFR80; TNFRII; Tnfr-1; Tnfr2; p75; p75 TNFR; p75TNFR; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. [MGI Ref ID J:45147]

Genotyping

Genotyping Information

Genotyping Protocols

Tnfrsf1atm1Imx, STD PCR, vers. 1
Tnfrsf1btm1Imx, , vers. 1
Tnfrsf1btm1Imx, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Cruceta J; Graves BD; Einhorn TA. 2001. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169(3):285-94. [PubMed: 11455125]  [MGI Ref ID J:70467]

Kassiotis G; Kollias G. 2001. Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (TNF) at the p55 TNF Receptor Level. Implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 193(4):427-34. [PubMed: 11181695]  [MGI Ref ID J:67610]

Tnfrsf1atm1Imx related

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Arnott CH; Scott KA; Moore RJ; Robinson SC; Thompson RG; Balkwill FR. 2004. Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene 23(10):1902-10. [PubMed: 14661063]  [MGI Ref ID J:89088]

Artis D; Humphreys NE; Bancroft AJ; Rothwell NJ; Potten CS; Grencis RK. 1999. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190(7):953-62. [PubMed: 10510085]  [MGI Ref ID J:115088]

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Baseta JG; Stutman O. 2000. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. J Immunol 165(10):5621-30. [PubMed: 11067918]  [MGI Ref ID J:112282]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. [PubMed: 18192488]  [MGI Ref ID J:134193]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Boone DL; Turer EE; Lee EG; Ahmad RC; Wheeler MT; Tsui C; Hurley P; Chien M; Chai S; Hitotsumatsu O; McNally E; Pickart C; Ma A. 2004. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5(10):1052-60. [PubMed: 15334086]  [MGI Ref ID J:92694]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Stachnick G; Castaneda D; Nayar J; Sriramarao P. 2001. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol 24(3):304-11. [PubMed: 11245629]  [MGI Ref ID J:114289]

Bruce AJ; Boling W; Kindy MS; Peschon J; Kraemer PJ; Carpenter MK; Holtsberg FW; Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2(7):788-94. [PubMed: 8673925]  [MGI Ref ID J:33864]

Calder CJ; Nicholson LB; Dick AD. 2005. A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol 175(10):6286-93. [PubMed: 16272279]  [MGI Ref ID J:119347]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Campbell LA; Nosaka T; Rosenfeld ME; Yaraei K; Kuo CC. 2005. Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice. Infect Immun 73(5):3164-5. [PubMed: 15845526]  [MGI Ref ID J:97619]

Campos-Neto A; Ovendale P; Bement T; Koppi TA; Fanslow WC; Rossi MA; Alderson MR. 1998. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 160(5):2037-41. [PubMed: 9498737]  [MGI Ref ID J:123032]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Chen LW; Egan L; Li ZW; Greten FR; Kagnoff MF; Karin M. 2003. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-81. [PubMed: 12692538]  [MGI Ref ID J:83313]

Chen SE; Gerken E; Zhang Y; Zhan M; Mohan RK; Li AS; Reid MB; Li YP. 2005. Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle. Am J Physiol Cell Physiol 289(5):C1179-87. [PubMed: 16079187]  [MGI Ref ID J:104990]

Chen SE; Jin B; Li YP. 2007. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292(5):C1660-71. [PubMed: 17151142]  [MGI Ref ID J:125884]

Chiu H; Gardner CR; Dambach DM; Brittingham JA; Durham SK; Laskin JD; Laskin DL. 2003. Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense. Am J Physiol Gastrointest Liver Physiol 285(5):G959-66. [PubMed: 12842828]  [MGI Ref ID J:86545]

Cliffe LJ; Potten CS; Booth CE; Grencis RK. 2007. An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection. Infect Immun 75(4):1556-64. [PubMed: 17242061]  [MGI Ref ID J:119507]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Crisostomo PR; Wang M; Herring CM; Markel TA; Meldrum KK; Lillemoe KD; Meldrum DR. 2007. Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1). J Mol Cell Cardiol 42(1):142-9. [PubMed: 17070836]  [MGI Ref ID J:119659]

Cunha TM; Verri WA Jr; Silva JS; Poole S; Cunha FQ; Ferreira SH. 2005. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A 102(5):1755-60. [PubMed: 15665080]  [MGI Ref ID J:96111]

Cusson N; Oikemus S; Kilpatrick ED; Cunningham L; Kelliher M. 2002. The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 196(1):15-26. [PubMed: 12093867]  [MGI Ref ID J:120699]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

De Paepe ME; Gundavarapu S; Tantravahi U; Pepperell JR; Haley SA; Luks FI; Mao Q. 2008. Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development. Am J Pathol 173(1):42-56. [PubMed: 18535181]  [MGI Ref ID J:137382]

Dela Pena A; Leclercq I; Field J; George J; Jones B; Farrell G. 2005. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 129(5):1663-74. [PubMed: 16285964]  [MGI Ref ID J:124937]

Drayton DL; Bonizzi G; Ying X; Liao S; Karin M; Ruddle NH. 2004. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol 173(10):6161-8. [PubMed: 15528353]  [MGI Ref ID J:94289]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114(1):71-7. [PubMed: 10620118]  [MGI Ref ID J:127060]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

Fu YX; Huang G; Matsumoto M; Molina H; Chaplin DD. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc Natl Acad Sci U S A 94(11):5739-43. [PubMed: 9159143]  [MGI Ref ID J:78647]

Gardner CR; Laskin JD; Dambach DM; Chiu H; Durham SK; Zhou P; Bruno M; Gerecke DR; Gordon MK; Laskin DL. 2003. Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators. Toxicol Appl Pharmacol 192(2):119-30. [PubMed: 14550746]  [MGI Ref ID J:132377]

Garlet GP; Cardoso CR; Campanelli AP; Ferreira BR; Avila-Campos MJ; Cunha FQ; Silva JS. 2007. The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 147(1):128-38. [PubMed: 17177972]  [MGI Ref ID J:116678]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Cruceta J; Graves BD; Einhorn TA. 2001. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169(3):285-94. [PubMed: 11455125]  [MGI Ref ID J:70467]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Tsay A; Fitch J; Barnes GL; Graves DT; Einhorn TA. 2003. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 18(9):1584-92. [PubMed: 12968667]  [MGI Ref ID J:111507]

Goluszko E; Deng C; Poussin MA; Christadoss P. 2002. Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis. J Neuroimmunol 122(1-2):85-93. [PubMed: 11777546]  [MGI Ref ID J:102961]

Gomez MI; Lee A; Reddy B; Muir A; Soong G; Pitt A; Cheung A; Prince A. 2004. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 10(8):842-8. [PubMed: 15247912]  [MGI Ref ID J:91608]

Greenfeld CR; Roby KF; Pepling ME; Babus JK; Terranova PF; Flaws JA. 2007. Tumor Necrosis Factor (TNF) Receptor Type 2 Is an Important Mediator of TNF alpha Function in the Mouse Ovary. Biol Reprod 76(2):224-31. [PubMed: 17065602]  [MGI Ref ID J:121169]

Guevara Patino JA; Ivanov VN; Lacy E; Elkon KB; Marino MW; Nikolic-Zugic J. 2000. TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. J Immunol 164(4):1689-94. [PubMed: 10657611]  [MGI Ref ID J:60398]

Guo G; Morrissey J; McCracken R; Tolley T; Liapis H; Klahr S. 2001. Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis. Am J Physiol Renal Physiol 280(5):F777-85. [PubMed: 11292619]  [MGI Ref ID J:69294]

Hanawa N; Shinohara M; Saberi B; Gaarde WA; Han D; Kaplowitz N. 2008. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283(20):13565-77. [PubMed: 18337250]  [MGI Ref ID J:137109]

He P; Zhong Z; Lindholm K; Berning L; Lee W; Lemere C; Staufenbiel M; Li R; Shen Y. 2007. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol 178(5):829-41. [PubMed: 17724122]  [MGI Ref ID J:134832]

Hildebrand F; Pape HC; Harwood P; Wittwer T; Krettek C; van Griensven M. 2004. Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents. Clin Exp Immunol 138(2):221-9. [PubMed: 15498030]  [MGI Ref ID J:93785]

Hill GR; Teshima T; Gerbitz A; Pan L; Cooke KR; Brinson YS; Crawford JM; Ferrara JL. 1999. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest 104(4):459-67. [PubMed: 10449438]  [MGI Ref ID J:115293]

Hill GR; Teshima T; Rebel VI; Krijanovski OI; Cooke KR; Brinson YS; Ferrara JL. 2000. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol 164(2):656-63. [PubMed: 10623807]  [MGI Ref ID J:59298]

Iizuka K; Chaplin DD; Wang Y; Wu Q; Pegg LE; Yokoyama WM; Fu YX. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci U S A 96(11):6336-40. [PubMed: 10339588]  [MGI Ref ID J:55470]

Ilg RC; Davies MH; Powers MR. 2005. Altered retinal neovascularization in TNF receptor-deficient mice. Curr Eye Res 30(11):1003-13. [PubMed: 16282134]  [MGI Ref ID J:104652]

Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJ; Bonde S; Kokaia Z; Jacobsen SE; Lindvall O. 2006. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26(38):9703-12. [PubMed: 16988041]  [MGI Ref ID J:112713]

Ismail N; Stevenson HL; Walker DH. 2006. Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infect Immun 74(3):1846-56. [PubMed: 16495559]  [MGI Ref ID J:107384]

Jessup HK; Brewer AW; Omori M; Rickel EA; Budelsky AL; Yoon BR; Ziegler SF; Comeau MR. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol 181(6):4311-9. [PubMed: 18768889]  [MGI Ref ID J:139079]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Jones MR; Simms BT; Lupa MM; Kogan MS; Mizgerd JP. 2005. Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 175(11):7530-5. [PubMed: 16301661]  [MGI Ref ID J:122167]

Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. [PubMed: 12133972]  [MGI Ref ID J:120707]

Kanehiro A; Lahn M; Makela MJ; Dakhama A; Joetham A; Rha YH; Born W; Gelfand EW. 2002. Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells. J Immunol 169(8):4190-7. [PubMed: 12370348]  [MGI Ref ID J:120174]

Keller C; Keller P; Giralt M; Hidalgo J; Pedersen BK. 2004. Exercise normalises overexpression of TNF-alpha in knockout mice. Biochem Biophys Res Commun 321(1):179-82. [PubMed: 15358232]  [MGI Ref ID J:91303]

Kitaura H; Sands MS; Aya K; Zhou P; Hirayama T; Uthgenannt B; Wei S; Takeshita S; Novack DV; Silva MJ; Abu-Amer Y; Ross FP; Teitelbaum SL. 2004. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol 173(8):4838-46. [PubMed: 15470024]  [MGI Ref ID J:93717]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

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