Strain Name:

B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J

Stock Number:

003244

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Availability:

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Mice homozygous for both targeted mutations lack both interlekin-1 beta type 1 receptor (IL1R1) and tumor necrosis factor alpha p55 (type 1) receptor (TNFR1). They exhibit reduced inflammatory responses and delayed-type hypersensitivity response. They are also susceptible to Listeria monocytogenes infection and have defects in Peyer's patch development, splenic architecture, formation of germinal centers and liver regeneration.

Description

Strain Information

Former Names Tnfr1    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   29-JUL-08
Maintain by HOM HOM x HOM HOM.
Specieslaboratory mouse
GenerationF?+19N1F16 (24-MAR-11)
Generation Definitions
 
Donating InvestigatorDr. Jacques Peschon,   Amgen

Appearance
white-bellied agouti
Related Genotype: Aw/Aw

Description
Mice homozygous for both targeted mutations (called TNFRp55(-/-)-IL-1RI(-/-), TNFR1/IL1R1 or IL-1R1/TNFR1 KO) are viable and fertile, lacking both interlekin-1 beta type 1 receptor (IL1R1) and tumor necrosis factor alpha p55 (type 1) receptor (TNFR1). Double homozygotes exhibit characteristics of both the single "knockouts" including reduced inflammatory responses, reduced delayed-type hypersensitivity response, and remain highly susceptible to infection by Listeria monocytogenes. Homozygous mutant mice also have defects in Peyer's patch development, splenic architecture, formation of germinal centers and liver regeneration. Furthermore, IL-1R1/TNFR1 KO mice exhibit alterations in rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS) (a sleep phenotype different from that observed for mice singly homozygous for one or the other of these cytokine receptors), as well as differences in NREMS and REMS following sleep deprivation compared to control mice.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il1r1tm1Imx allele
003245   B6.129S7-Il1r1tm1Imx/J
View Strains carrying   Il1r1tm1Imx     (1 strain)

Strains carrying   Tnfrsf1atm1Imx allele
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
003242   C57BL/6-Tnfrsf1atm1Imx/J
View Strains carrying   Tnfrsf1atm1Imx     (2 strains)

Strains carrying other alleles of Il1r1
003018   B6;129S1-Il1r1tm1Roml/J
005078   NOD.Cg-Il1r1tm1Roml/HetJ
View Strains carrying other alleles of Il1r1     (2 strains)

Strains carrying other alleles of Tnfrsf1a
002818   B6.129-Tnfrsf1atm1Mak/J
View Strains carrying other alleles of Tnfrsf1a     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Multiple Sclerosis, Susceptibility to, 5; MS5   (TNFRSF1A)
Periodic Fever, Familial, Autosomal Dominant   (TNFRSF1A)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il1r1tm1Imx/Il1r1tm1Imx Tnfrsf1atm1Imx/Tnfrsf1atm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal chemokine level
    • there is 2-fold less levels of Cxcl1 (KC) found in the bronchoalveolar lavage fluid of lungs infected with E. coli compared to infected wild-type mice   (MGI Ref ID J:126652)
  • decreased interleukin-6 secretion
    • into the aqueous humor following induction of uveitis   (MGI Ref ID J:115094)
  • decreased susceptibility to experimental autoimmune uveoretinitis
    • following reverse passive Arthus reaction to induce uveitis, mice exhibit reduced cellular infiltration into the anterior and posterior segments and IL6 secretion into the aqueous humor compared with wild-type mice   (MGI Ref ID J:115094)
  • impaired neutrophil recruitment
    • lungs infected with E. coli have decreased amounts of neutrophils that emigrate from the alveolar septae   (MGI Ref ID J:126652)
    • neutrophil numbers in circulation or sequestered within the alveolar septae are similar to wild-type   (MGI Ref ID J:126652)
  • increased susceptibility to bacterial infection
    • mice have 4 log greater bacterial penetration of the dental pulp eight days after experimental bacterial infection   (MGI Ref ID J:58851)
  • lung inflammation
    • patchy pulmonary inflammation occurs spontaneously in about 2/3rd of mice   (MGI Ref ID J:126652)
    • infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue   (MGI Ref ID J:126652)
    • eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas   (MGI Ref ID J:126652)
    • interstitial pneumonia
      • lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma   (MGI Ref ID J:126652)
  • osteomyelitis
    • osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene   (MGI Ref ID J:58851)
    • the osteolytic lesions continue to be larger for at least 38 days after inoculation   (MGI Ref ID J:58851)
  • skeleton phenotype
  • increased bone resorption
    • there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp   (MGI Ref ID J:58851)
    • osteoclast activity of the molars is 5-fold higher than in wild-types 7 days after bacterial inoculation   (MGI Ref ID J:58851)
  • osteomyelitis
    • osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene   (MGI Ref ID J:58851)
    • the osteolytic lesions continue to be larger for at least 38 days after inoculation   (MGI Ref ID J:58851)
  • respiratory system phenotype
  • lung inflammation
    • patchy pulmonary inflammation occurs spontaneously in about 2/3rd of mice   (MGI Ref ID J:126652)
    • infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue   (MGI Ref ID J:126652)
    • eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas   (MGI Ref ID J:126652)
    • interstitial pneumonia
      • lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma   (MGI Ref ID J:126652)
  • homeostasis/metabolism phenotype
  • abnormal chemokine level
    • there is 2-fold less levels of Cxcl1 (KC) found in the bronchoalveolar lavage fluid of lungs infected with E. coli compared to infected wild-type mice   (MGI Ref ID J:126652)
  • hematopoietic system phenotype
  • impaired neutrophil recruitment
    • lungs infected with E. coli have decreased amounts of neutrophils that emigrate from the alveolar septae   (MGI Ref ID J:126652)
    • neutrophil numbers in circulation or sequestered within the alveolar septae are similar to wild-type   (MGI Ref ID J:126652)
  • craniofacial phenotype
  • dental pulp necrosis
    • mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation   (MGI Ref ID J:58851)
    • complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation   (MGI Ref ID J:58851)
  • growth/size/body phenotype
  • dental pulp necrosis
    • mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation   (MGI Ref ID J:58851)
    • complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation   (MGI Ref ID J:58851)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Il1r1tm1Imx related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Tnfrsf1atm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il1r1tm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-1R1-; IL-1R-; IL-1RI KO; IL-R1-; Il1r1tm1jmx; Il1rtm1Imx; RIko;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Il1r1, interleukin 1 receptor, type I
Chromosome 1
Gene Common Name(s) CD121A; D2S1473; IL-1 receptor alpha chain; IL-1R-alpha; IL-1R1; IL-iR; IL1R; IL1RA; Il1r-1; P80;
Molecular Note A neomycin resistance cassette replaced two exons of the gene, which encode amino acids 4 - 225 of the mature protein. [MGI Ref ID J:43088]
 
Allele Symbol Tnfrsf1atm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (Null/Knockout)
Common Name(s) Preschon Tnfrsf1a-; TNF-alpha-R1; TNFR1-; TNFR-; TNFRI-; Tnfrsf1atm1Imx; p55 KO; p55-;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of OriginC57BL/6
Gene Symbol and Name Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
Chromosome 6
Gene Common Name(s) CD120a; FPF; MS5; TBP1; TNF receptor alpha chain; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-alpha-R1; TNF-alphaR1; TNFAR; TNFR-1; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRI; TNFRp55; TNFalpha-R1; Tnfr-2; Tnfr1; p55; p55-R; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. [MGI Ref ID J:110548] [MGI Ref ID J:45147]

Genotyping

Genotyping Information

Genotyping Protocols

Il1r1tm1Imx-Alternate 1, Standard PCR
Tnfrsf1atm1Imx,

Separated MCA


Tnfrsf1atm1Imx, High Resolution Melting
Tnfrsf1atm1Imx, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Glaccum MB; Stocking KL; Charrier K; Smith JL; Willis CR; Maliszewski C ; Livingston DJ ; Peschon JJ ; Morrissey PJ. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-71. [PubMed: 9317135]  [MGI Ref ID J:43088]

Mizgerd JP; Spieker MR; Doerschuk CM. 2001. Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol 166(6):4042-8. [PubMed: 11238652]  [MGI Ref ID J:126652]

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Il1r1tm1Imx related

Abcouwer SF; Norman J; Fink G; Carter G; Lustig RJ; Souba WW. 1996. Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice. Surgery 120(2):255-63; discussion 263-4. [PubMed: 8751591]  [MGI Ref ID J:114173]

Abdalla H; Srinivasan L; Shah S; Mayer-Barber KD; Sher A; Sutterwala FS; Briken V. 2012. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1beta and IL-18 secretion but not to pyroptosis. PLoS One 7(7):e40722. [PubMed: 22911706]  [MGI Ref ID J:189888]

Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70-9. [PubMed: 22201681]  [MGI Ref ID J:184390]

Allen RG; Lafuse WP; Powell ND; Webster Marketon JI; Stiner-Jones LM; Sheridan JF; Bailey MT. 2012. Stressor-Induced Increase in Microbicidal Activity of Splenic Macrophages Is Dependent upon Peroxynitrite Production. Infect Immun 80(10):3429-37. [PubMed: 22825446]  [MGI Ref ID J:187596]

Andoh T; Kishi H; Motoki K; Nakanishi K; Kuraishi Y; Muraguchi A. 2008. Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice. J Immunol 180(4):2322-8. [PubMed: 18250441]  [MGI Ref ID J:131996]

Andre R; Moggs JG; Kimber I; Rothwell NJ; Pinteaux E. 2006. Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia 53(5):477-83. [PubMed: 16358337]  [MGI Ref ID J:156138]

Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. [PubMed: 18941239]  [MGI Ref ID J:140719]

Baccarella A; Fontana MF; Chen EC; Kim CC. 2013. Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun 81(12):4431-42. [PubMed: 24042114]  [MGI Ref ID J:202330]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Basu A; Lazovic J; Krady JK; Mauger DT; Rothstein RP; Smith MB; Levison SW. 2005. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25(1):17-29. [PubMed: 15678109]  [MGI Ref ID J:105286]

Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. [PubMed: 21741932]  [MGI Ref ID J:176323]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Bluthe RM; Laye S; Michaud B; Combe C; Dantzer R; Parnet P. 2000. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12(12):4447-56. [PubMed: 11122355]  [MGI Ref ID J:112148]

Boettcher S; Ziegler P; Schmid MA; Takizawa H; van Rooijen N; Kopf M; Heikenwalder M; Manz MG. 2012. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J Immunol 188(12):5824-8. [PubMed: 22586037]  [MGI Ref ID J:188869]

Bonnet MC; Preukschat D; Welz PS; van Loo G; Ermolaeva MA; Bloch W; Haase I; Pasparakis M. 2011. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity 35(4):572-82. [PubMed: 22000287]  [MGI Ref ID J:177639]

Brinster C; Shevach EM. 2008. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J Leukoc Biol 84(2):480-7. [PubMed: 18477692]  [MGI Ref ID J:138445]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Campbell K; Gifford T; Sriramarao P. 2000. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood 95(1):263-9. [PubMed: 10607711]  [MGI Ref ID J:110254]

Bulua AC; Simon A; Maddipati R; Pelletier M; Park H; Kim KY; Sack MN; Kastner DL; Siegel RM. 2011. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208(3):519-33. [PubMed: 21282379]  [MGI Ref ID J:176847]

Bunt SK; Yang L; Sinha P; Clements VK; Leips J; Ostrand-Rosenberg S. 2007. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67(20):10019-26. [PubMed: 17942936]  [MGI Ref ID J:126013]

Cai S; Batra S; Wakamatsu N; Pacher P; Jeyaseelan S. 2012. NLRC4 inflammasome-mediated production of IL-1beta modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol 188(11):5623-35. [PubMed: 22547706]  [MGI Ref ID J:188721]

Carmi Y; Dotan S; Rider P; Kaplanov I; White MR; Baron R; Abutbul S; Huszar M; Dinarello CA; Apte RN; Voronov E. 2013. The Role of IL-1beta in the Early Tumor Cell-Induced Angiogenic Response. J Immunol 190(7):3500-9. [PubMed: 23475218]  [MGI Ref ID J:194907]

Cassel SL; Janczy JR; Bing X; Wilson SP; Olivier AK; Otero JE; Iwakura Y; Shayakhmetov DM; Bassuk AG; Abu-Amer Y; Brogden KA; Burns TL; Sutterwala FS; Ferguson PJ. 2014. Inflammasome-independent IL-1beta mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A 111(3):1072-7. [PubMed: 24395802]  [MGI Ref ID J:206468]

Ceballos-Olvera I; Sahoo M; Miller MA; Del Barrio L; Re F. 2011. Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1beta is deleterious. PLoS Pathog 7(12):e1002452. [PubMed: 22241982]  [MGI Ref ID J:183297]

Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168(4):1396-403. [PubMed: 16565512]  [MGI Ref ID J:107324]

Chamberlain J; Francis S; Brookes Z; Shaw G; Graham D; Alp NJ; Dower S; Crossman DC. 2009. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE 4(4):e5073. [PubMed: 19347044]  [MGI Ref ID J:148173]

Chamberlain J; Wheatcroft M; Arnold N; Lupton H; Crossman DC; Gunn J; Francis S. 2010. A novel mouse model of in situ stenting. Cardiovasc Res 85(1):38-44. [PubMed: 19633315]  [MGI Ref ID J:172559]

Chen CJ; Kono H; Golenbock D; Reed G; Akira S; Rock KL. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 13(7):851-6. [PubMed: 17572686]  [MGI Ref ID J:125088]

Chen CJ; Shi Y; Hearn A; Fitzgerald K; Golenbock D; Reed G; Akira S; Rock KL. 2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116(8):2262-71. [PubMed: 16886064]  [MGI Ref ID J:113110]

Chen Q; Sen G; Snapper CM. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177(9):6044-51. [PubMed: 17056530]  [MGI Ref ID J:140525]

Chen VL; Surana NK; Duan J; Kasper DL. 2013. Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in salmonella infection. PLoS One 8(6):e65405. [PubMed: 23750260]  [MGI Ref ID J:204259]

Chen YT; Chen FY; Vijmasi T; Stephens DN; Gallup M; McNamara NA. 2013. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One 8(10):e77286. [PubMed: 24143217]  [MGI Ref ID J:209118]

Chen YT; Lazarev S; Bahrami AF; Noble LB; Chen FY; Zhou D; Gallup M; Yadav M; McNamara NA. 2012. Interleukin-1 receptor mediates the interplay between CD4(+) T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjogren's syndrome. Lab Invest 92(4):556-70. [PubMed: 22231738]  [MGI Ref ID J:181948]

Chen YT; Nikulina K; Lazarev S; Bahrami AF; Noble LB; Gallup M; McNamara NA. 2010. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjogren's syndrome. Am J Pathol 177(3):1333-43. [PubMed: 20696775]  [MGI Ref ID J:163691]

Cho JS; Guo Y; Ramos RI; Hebroni F; Plaisier SB; Xuan C; Granick JL; Matsushima H; Takashima A; Iwakura Y; Cheung AL; Cheng G; Lee DJ; Simon SI; Miller LS. 2012. Neutrophil-derived IL-1beta is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog 8(11):e1003047. [PubMed: 23209417]  [MGI Ref ID J:195003]

Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. [PubMed: 20364087]  [MGI Ref ID J:161481]

Chung Y; Chang SH; Martinez GJ; Yang XO; Nurieva R; Kang HS; Ma L; Watowich SS; Jetten AM; Tian Q; Dong C. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87. [PubMed: 19362022]  [MGI Ref ID J:147961]

Claycomb RJ; Hewett SJ; Hewett JA. 2012. Neuromodulatory role of endogenous interleukin-1beta in acute seizures: possible contribution of cyclooxygenase-2. Neurobiol Dis 45(1):234-42. [PubMed: 21856425]  [MGI Ref ID J:179846]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Dapito DH; Mencin A; Gwak GY; Pradere JP; Jang MK; Mederacke I; Caviglia JM; Khiabanian H; Adeyemi A; Bataller R; Lefkowitch JH; Bower M; Friedman R; Sartor RB; Rabadan R; Schwabe RF. 2012. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21(4):504-16. [PubMed: 22516259]  [MGI Ref ID J:189330]

Dekaris I; Zhu SN; Dana MR. 1999. TNF-alpha regulates corneal Langerhans cell migration. J Immunol 162(7):4235-9. [PubMed: 10201952]  [MGI Ref ID J:111008]

Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31(1):110-21. [PubMed: 19576795]  [MGI Ref ID J:151628]

Elinav E; Strowig T; Kau AL; Henao-Mejia J; Thaiss CA; Booth CJ; Peaper DR; Bertin J; Eisenbarth SC; Gordon JI; Flavell RA. 2011. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell 145(5):745-57. [PubMed: 21565393]  [MGI Ref ID J:173245]

Ermann J; Staton T; Glickman JN; de Waal Malefyt R; Glimcher LH. 2014. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. Proc Natl Acad Sci U S A 111(25):E2559-66. [PubMed: 24927559]  [MGI Ref ID J:212092]

Fogal B; Li J; Lobner D; McCullough LD; Hewett SJ. 2007. System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury. J Neurosci 27(38):10094-105. [PubMed: 17881516]  [MGI Ref ID J:145224]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

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Wang M; Crisostomo PR; Markel TA; Wang Y; Meldrum DR. 2008. Mechanisms of sex differences in TNFR2-mediated cardioprotection. Circulation 118(14 Suppl):S38-45. [PubMed: 18824767]  [MGI Ref ID J:158041]

Wang Q; Chang L; Rowan MJ; Anwyl R. 2007. Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus. Neuroscience 144(1):110-8. [PubMed: 17055173]  [MGI Ref ID J:117954]

Wang Q; Wu J; Rowan MJ; Anwyl R. 2005. Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor. Eur J Neurosci 22(11):2827-32. [PubMed: 16324117]  [MGI Ref ID J:104311]

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Wiede F; Roomberg A; Cretney E; Lechner A; Fromm P; Wren L; Smyth MJ; Korner H. 2009. Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice. J Leukoc Biol 85(1):108-16. [PubMed: 18948547]  [MGI Ref ID J:144623]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThe strain is maintained by mating mice homozygous for both targeted mutations together (HOM HOM x HOM HOM). Expected coat color from breeding is White Bellied Agouti or Black.
Mating SystemHomozygote x Homozygote         (Female x Male)   29-JUL-08
Maintain by HOM HOM x HOM HOM.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx x Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx x Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
Surgical and Preconditioning Services
JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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