Description

Strain Information

Former Names Tnfr1    (Changed: 15-DEC-04 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote         (Female x Male) Maintain by HOM HOM x HOM HOM. Species laboratory mouse Generation F?+19N1F11 (31-DEC-07)   Donating Investigator Jacques Peschon,   Amgen

Appearance
white-bellied agouti
Related Genotype: A^w/A^w

Description
Mice homozygous for both targeted mutations (called TNFRp55(-/-)-IL-1RI(-/-), TNFR1/IL1R1 or IL-1R1/TNFR1 KO) are viable and fertile, lacking both interlekin-1 beta type 1 receptor (IL1R1) and tumor necrosis factor alpha p55 (type 1) receptor (TNFR1). Double homozygotes exhibit characteristics of both the single "knockouts" including reduced inflammatory responses, reduced delayed-type hypersensitivity response, and remain highly susceptible to infection by Listeria monocytogenes. Homozygous mutant mice also have defects in Peyer's patch development, splenic architecture, formation of germinal centers and liver regeneration. Furthermore, IL-1R1/TNFR1 KO mice exhibit alterations in rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS) (a sleep phenotype different from that observed for mice singly homozygous for one or the other of these cytokine receptors), as well as differences in NREMS and REMS following sleep deprivation compared to control mice.

Control Information

Related Strains

Strains carrying   Il1r1^tm1Imx allele

003245

B6.129S7-Il1r1tm1Imx/J

View Strains carrying   Il1r1^tm1Imx     (1 strain)

Strains carrying   Tnfrsf1a^tm1Imx allele

003243	B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
003242	C57BL/6-Tnfrsf1atm1Imx/J

View Strains carrying   Tnfrsf1a^tm1Imx     (2 strains)

Strains carrying other alleles of Il1r1

003018	B6;129S1-Il1r1tm1Roml/J
005078	NOD.Cg-Il1r1tm1Roml/HetJ

View Strains carrying other alleles of Il1r1     (2 strains)

Strains carrying other alleles of Tnfrsf1a

002818

B6.129-Tnfrsf1atm1Mak/J

View Strains carrying other alleles of Tnfrsf1a     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Il1r1^tm1Imx/Il1r1^tm1Imx Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx

        involves: 129 * C57BL/6

• immune system phenotype
• abnormal chemokine level (MGI Ref ID J:126652)
  • there is 2-fold less levels of Cxcl1 (KC) found in the bronchoalveolar lavage fluid of lungs infected with E. coli compared to infected wild-type mice
• impaired neutrophil recruitment (MGI Ref ID J:126652)
  • lungs infected with E. coli have decreased amounts of neutrophils that emigrate from the alveolar septae
  • neutrophil numbers in circulation or sequestered within the alveolar septae are similar to wild-type
• increased susceptibility to bacterial infection (MGI Ref ID J:58851)
  • mice have 4 log greater bacterial penetration of the dental pulp eight days after experimental bacterial infection
• lung inflammation (MGI Ref ID J:126652)
  • patchy pulmonary inflammation occurs spontaneously in about 2/3^rd of mice
  • infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue
  • eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas
• interstitial pneumonia (MGI Ref ID J:126652)
  • lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma
• osteomyelitis (MGI Ref ID J:58851)
  • osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene
  • the osteolytic lesions continue to be larger for at least 38 days after inoculation
• skeleton phenotype
• increased bone resorption (MGI Ref ID J:58851)
  • there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp
  • osteoclast activity of the molars is 5-fold higher than in wild-types 7 days after bacterial inoculation
• osteomyelitis (MGI Ref ID J:58851)
  • osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene
  • the osteolytic lesions continue to be larger for at least 38 days after inoculation
• cellular phenotype
• necrosis (MGI Ref ID J:58851)
  • mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation
  • complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation
• respiratory system phenotype
• lung inflammation (MGI Ref ID J:126652)
  • patchy pulmonary inflammation occurs spontaneously in about 2/3^rd of mice
  • infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue
  • eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas
• interstitial pneumonia (MGI Ref ID J:126652)
  • lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Il1r1^tm1Imx related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Tnfrsf1a^tm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information

Genotyping

Genotyping Information

Genotyping Protocols

Il1r1^tm1Imx, SEP PCR, vers. 2
Tnfrsf1a^tm1Imx, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Glaccum MB; Stocking KL; Charrier K; Smith JL; Willis CR; Maliszewski C ; Livingston DJ ; Peschon JJ ; Morrissey PJ. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-71. [PubMed: 9317135]  [MGI Ref ID J:43088]

Mizgerd JP; Spieker MR; Doerschuk CM. 2001. Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol 166(6):4042-8. [PubMed: 11238652]  [MGI Ref ID J:126652]

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Il1r1^tm1Imx related

Abcouwer SF; Norman J; Fink G; Carter G; Lustig RJ; Souba WW. 1996. Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice. Surgery 120(2):255-63; discussion 263-4. [PubMed: 8751591]  [MGI Ref ID J:114173]

Andoh T; Kishi H; Motoki K; Nakanishi K; Kuraishi Y; Muraguchi A. 2008. Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice. J Immunol 180(4):2322-8. [PubMed: 18250441]  [MGI Ref ID J:131996]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Basu A; Lazovic J; Krady JK; Mauger DT; Rothstein RP; Smith MB; Levison SW. 2005. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25(1):17-29. [PubMed: 15678109]  [MGI Ref ID J:105286]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Bluthe RM; Laye S; Michaud B; Combe C; Dantzer R; Parnet P. 2000. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12(12):4447-56. [PubMed: 11122355]  [MGI Ref ID J:112148]

Brinster C; Shevach EM. 2008. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J Leukoc Biol 84(2):480-7. [PubMed: 18477692]  [MGI Ref ID J:138445]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Campbell K; Gifford T; Sriramarao P. 2000. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood 95(1):263-9. [PubMed: 10607711]  [MGI Ref ID J:110254]

Bunt SK; Yang L; Sinha P; Clements VK; Leips J; Ostrand-Rosenberg S. 2007. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67(20):10019-26. [PubMed: 17942936]  [MGI Ref ID J:126013]

Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168(4):1396-403. [PubMed: 16565512]  [MGI Ref ID J:107324]

Chen CJ; Kono H; Golenbock D; Reed G; Akira S; Rock KL. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 13(7):851-6. [PubMed: 17572686]  [MGI Ref ID J:125088]

Chen CJ; Shi Y; Hearn A; Fitzgerald K; Golenbock D; Reed G; Akira S; Rock KL. 2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116(8):2262-71. [PubMed: 16886064]  [MGI Ref ID J:113110]

Chen Q; Sen G; Snapper CM. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177(9):6044-51. [PubMed: 17056530]  [MGI Ref ID J:140525]

Dekaris I; Zhu SN; Dana MR. 1999. TNF-alpha regulates corneal Langerhans cell migration. J Immunol 162(7):4235-9. [PubMed: 10201952]  [MGI Ref ID J:111008]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

Garcia MC; Wernstedt I; Berndtsson A; Enge M; Bell M; Hultgren O; Horn M; Ahren B; Enerback S; Ohlsson C; Wallenius V; Jansson JO. 2006. Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes 55(5):1205-13. [PubMed: 16644674]  [MGI Ref ID J:108634]

Grcevic D; Lee SK; Marusic A; Lorenzo JA. 2000. Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis. J Immunol 165(8):4231-8. [PubMed: 11035056]  [MGI Ref ID J:119159]

Haq M; Norman J; Saba SR; Ramirez G; Rabb H. 1998. Role of IL-1 in renal ischemic reperfusion injury. J Am Soc Nephrol 9(4):614-9. [PubMed: 9555664]  [MGI Ref ID J:112999]

Hebert G; Mingam R; Arsaut J; Dantzer R; Demotes-Mainard J. 2005. A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice. Brain Res Mol Brain Res 136(1-2):267-70. [PubMed: 15893609]  [MGI Ref ID J:99360]

Huang H; Wise GE. 2000. Delay of tooth eruption in null mice devoid of the type I IL-1R gene. Eur J Oral Sci 108(4):297-302. [PubMed: 10946764]  [MGI Ref ID J:103141]

Hultgren OH; Svensson L; Tarkowski A. 2002. Critical role of signaling through IL-1 receptor for development of arthritis and sepsis during Staphylococcus aureus infection. J Immunol 168(10):5207-12. [PubMed: 11994477]  [MGI Ref ID J:125570]

Irikura VM; Lagraoui M; Hirsh D. 2002. The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor. J Immunol 169(1):393-8. [PubMed: 12077269]  [MGI Ref ID J:123841]

Islam Z; Pestka JJ. 2003. Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. Toxicol Sci 74(1):93-102. [PubMed: 12773775]  [MGI Ref ID J:126517]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Jones MR; Simms BT; Lupa MM; Kogan MS; Mizgerd JP. 2005. Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 175(11):7530-5. [PubMed: 16301661]  [MGI Ref ID J:122167]

Kalns J; Scruggs J; Millenbaugh N; Vivekananda J; Shealy D; Eggers J; Kiel J. 2002. TNF Receptor 1, IL-1 Receptor, and iNOS Genetic Knockout Mice Are Not Protected from Anthrax Infection. Biochem Biophys Res Commun 292(1):41-4. [PubMed: 11890668]  [MGI Ref ID J:75694]

Kato A; Gabay C; Okaya T; Lentsch AB. 2002. Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion. Am J Pathol 161(5):1797-803. [PubMed: 12414526]  [MGI Ref ID J:79907]

Kawai T; Adachi O; Ogawa T; Takeda K; Akira S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11(1):115-22. [PubMed: 10435584]  [MGI Ref ID J:91224]

King M; Pearson T; Shultz LD; Leif J; Bottino R; Trucco M; Atkinson MA; Wasserfall C; Herold KC; Woodland RT; Schmidt MR; Woda BA; Thompson MJ; Rossini AA; Greiner DL. 2008. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 126(3):303-14. [PubMed: 18096436]  [MGI Ref ID J:131635]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

Koo JW; Duman RS. 2008. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105(2):751-6. [PubMed: 18178625]  [MGI Ref ID J:131025]

Laing GD; Clissa PB; Theakston RD; Moura-da-Silva AM; Taylor MJ. 2003. Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis. Eur J Immunol 33(12):3458-63. [PubMed: 14635056]  [MGI Ref ID J:87138]

Lazovic J; Basu A; Lin HW; Rothstein RP; Krady JK; Smith MB; Levison SW. 2005. Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke 36(10):2226-31. [PubMed: 16179572]  [MGI Ref ID J:114428]

Lind MH; Rozell B; Wallin RP; van Hogerlinden M; Ljunggren HG; Toftgard R; Sur I. 2004. Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Proc Natl Acad Sci U S A 101(14):4972-7. [PubMed: 15044707]  [MGI Ref ID J:89239]

Lorenzo JA; Naprta A; Rao Y; Alander C; Glaccum M; Widmer M; Gronowicz G; Kalinowski J; Pilbeam CC. 1998. Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy. Endocrinology 139(6):3022-5. [PubMed: 9607815]  [MGI Ref ID J:108815]

Lu B; Sims PJ; Wiedmer T; Moser AH; Shigenaga JK; Grunfeld C; Feingold KR. 2007. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Biochim Biophys Acta 1771(9):1177-85. [PubMed: 17590392]  [MGI Ref ID J:127023]

Miller LS; O'Connell RM; Gutierrez MA; Pietras EM; Shahangian A; Gross CE; Thirumala A; Cheung AL; Cheng G; Modlin RL. 2006. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24(1):79-91. [PubMed: 16413925]  [MGI Ref ID J:113315]

Nambu A; Nakae S; Iwakura Y. 2006. IL-1{beta}, but not IL-1{alpha}, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses. Int Immunol 18(5):701-12. [PubMed: 16569679]  [MGI Ref ID J:108548]

Nandakumar KS; Holmdahl R. 2006. Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18. [PubMed: 16688680]  [MGI Ref ID J:115066]

Norman JG; Fink GW; Sexton C; Carter G. 1996. Transgenic animals demonstrate a role for the IL-1 receptor in regulating IL-1beta gene expression at steady-state and during the systemic stress induced by acute pancreatitis. J Surg Res 63(1):231-6. [PubMed: 8661203]  [MGI Ref ID J:110751]

Noulin N; Quesniaux VF; Schnyder-Candrian S; Schnyder B; Maillet I; Robert T; Vargaftig BB; Ryffel B; Couillin I. 2005. Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol 175(10):6861-9. [PubMed: 16272344]  [MGI Ref ID J:119696]

Peck-Palmer OM; Unsinger J; Chang KC; Davis CG; McDunn JE; Hotchkiss RS. 2008. Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol 83(4):1009-18. [PubMed: 18211965]  [MGI Ref ID J:134048]

Rad R; Brenner L; Krug A; Voland P; Mages J; Lang R; Schwendy S; Reindl W; Dossumbekova A; Ballhorn W; Wagner H; Schmid RM; Bauer S; Prinz C. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133(1):150-163.e3. [PubMed: 17631139]  [MGI Ref ID J:128297]

Rijneveld AW; Florquin S; Branger J; Speelman P; Van Deventer SJ; van Der Poll T. 2001. Tnf-alpha compensates for the impaired host defense of il-1 type i receptor-deficient mice during pneumococcal pneumonia. J Immunol 167(9):5240-6. [PubMed: 11673538]  [MGI Ref ID J:72672]

Rosenzweig HL; Martin TM; Planck SR; Galster K; Jann MM; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol 84(2):529-36. [PubMed: 18495787]  [MGI Ref ID J:138433]

Sanders CJ; Moore DA rd; Williams IR; Gewirtz AT. 2008. Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol 180(11):7184-92. [PubMed: 18490717]  [MGI Ref ID J:136347]

Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. [PubMed: 17229673]  [MGI Ref ID J:121446]

Schnyder-Candrian S; Quesniaux VF; Di Padova F; Maillet I; Noulin N; Couillin I; Moser R; Erard F; Vargaftig BB; Ryffel B; Schnyder B. 2005. Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol 175(1):262-9. [PubMed: 15972657]  [MGI Ref ID J:100580]

Schultz MJ; Rijneveld AW; Florquin S; Edwards CK; Dinarello CA; van der Poll T. 2002. Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 282(2):L285-90. [PubMed: 11792633]  [MGI Ref ID J:108270]

Sewnath ME; Van Der Poll T; Ten Kate FJ; Van Noorden CJ; Gouma DJ. 2002. Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin. Hepatology 35(1):149-58. [PubMed: 11786971]  [MGI Ref ID J:105837]

Shaftel SS; Carlson TJ; Olschowka JA; Kyrkanides S; Matousek SB; O'Banion MK. 2007. Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci 27(35):9301-9. [PubMed: 17728444]  [MGI Ref ID J:124945]

Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. 2007. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595-604. [PubMed: 17549256]  [MGI Ref ID J:122022]

Su SB; Silver PB; Grajewski RS; Agarwal RK; Tang J; Chan CC; Caspi RR. 2005. Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 175(10):6303-10. [PubMed: 16272281]  [MGI Ref ID J:119346]

Togbe D; Aurore G; Noulin N; Quesniaux VF; Schnyder-Candrian S; Schnyder B; Vasseur V; Akira S; Hoebe K; Beutler B; Ryffel B; Couillin I. 2006. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab Invest 86(11):1126-35. [PubMed: 16983331]  [MGI Ref ID J:114842]

Touzani O; Boutin H; LeFeuvre R; Parker L; Miller A; Luheshi G; Rothwell N. 2002. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J Neurosci 22(1):38-43. [PubMed: 11756486]  [MGI Ref ID J:112422]

Turnbull AV; Prehar S; Kennedy AR; Little RA; Hopkins SJ. 2003. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 144(5):1894-906. [PubMed: 12697697]  [MGI Ref ID J:115710]

Vincent JA; Mohr S. 2007. Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56(1):224-30. [PubMed: 17192486]  [MGI Ref ID J:121933]

Wei S; Kitaura H; Zhou P; Ross FP; Teitelbaum SL. 2005. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest 115(2):282-90. [PubMed: 15668736]  [MGI Ref ID J:95955]

Xie C; Qin X; Jonnala G; Gong Y; Yan M; Zong P; Zhou XJ; Mohan C. 2007. Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56. [PubMed: 17500042]  [MGI Ref ID J:123515]

Zare F; Bokarewa M; Nenonen N; Bergstrom T; Alexopoulou L; Flavell RA; Tarkowski A. 2004. Arthritogenic properties of double-stranded (viral) RNA. J Immunol 172(9):5656-63. [PubMed: 15100310]  [MGI Ref ID J:89689]

Zare F; Magnusson M; Mollers LN; Jin T; Tarkowski A; Bokarewa M. 2008. Single-stranded polyinosinic acid oligonucleotides trigger leukocyte production of proteins belonging to fibrinolytic and coagulation cascades. J Leukoc Biol 84(3):741-7. [PubMed: 18562486]  [MGI Ref ID J:138145]

Zhou S; Halle A; Kurt-Jones EA; Cerny AM; Porpiglia E; Rogers M; Golenbock DT; Finberg RW. 2008. Lymphocytic Choriomeningitis Virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J Neuroimmunol 194(1-2):70-82. [PubMed: 18295350]  [MGI Ref ID J:132676]

Zwijnenburg PJ; Van Der Poll T; Florquin S; Roord JJ; Van Furth AM. 2003. IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis. J Immunol 170(9):4724-30. [PubMed: 12707352]  [MGI Ref ID J:83019]

Tnfrsf1a^tm1Imx related

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & Husbandry	The strain is maintained by mating mice homozygous for both targeted mutations together (HOM HOM x HOM HOM). Expected coat color from breeding is White Bellied Agouti or Black.
Mating System	Homozygote x Homozygote         (Female x Male)
	Maintain by HOM HOM x HOM HOM.
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$104.80	Female or Male	Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx

Pairs /Price*	Pair Genotype
$209.60	Homozygous for Tnfrsf1atm1Imx, Homozygous for Il1r1tm1Imx x Homozygous for Tnfrsf1atm