Strain Name:

B6.129S7-Il1r1tm1Imx/J

Stock Number:

003245

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IL-1 receptor KO mice exhibit altered innate immune and inflammatory responses and show multiple effects on physiological systems and behavior.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2)
GenerationN5+N2F2 (06-OCT-09)
Generation Definitions
 
Donating InvestigatorDr. Jacques Peschon,   Amgen

Appearance
black
Related Genotype: a/a

Description
   Interleukin 1 receptor, type I, is a receptor for interleukin 1 (IL1), which affects many cytokine induced immune and inflammatory responses. Mice homozygous for the Il1rtm1Imx targeted mutation therefore fail to respond to IL1 and exhibit an altered immune response to many different target proteins. Some effects seen from knocking out this receptor include defective responses to certain inflammatory agents such as turpentine and altered response to various pathogenic organisms such as S. aureus and C. pneumoniae.
   Other observed effects include enhanced glucose homeostasis, enhanced insulin sensitivity of adipose tissue, reduction in diet-induced systemic atherosclerosis, improved restoration of normal skin architecture in wounds, increased incidence of acute convulsive seizures induced by pentylenetetrazole, and a decrease in anxiety-related behaviors.

Development
A null mutation in Il1r1 was generated by homologous recombination in 129/SvEv AB1 ES cells using a replacement vector in which a 2.4 kb EcoR1-Pst1 fragment encompassing two exons was replaced with a PGKneo cassette. Targeted mutant mice were backcrossed 5 times to C57BL/6 prior to importation.

In March 2011, a 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. 26 of 27 markers throughout the genome indicate a C57BL/6 genetic background. One marker at ~100 Mbp of chromosome 9 is segregating for an allele-type other than C57BL/6 or 129S. In addition, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background or a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il1r1tm1Imx allele
003244   B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
View Strains carrying   Il1r1tm1Imx     (1 strain)

Strains carrying other alleles of Il1r1
003018   B6;129S1-Il1r1tm1Roml/J
005078   NOD.Cg-Il1r1tm1Roml/HetJ
View Strains carrying other alleles of Il1r1     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il1r1tm1Imx/Il1r1tm1Imx

        B6.129S7-Il1r1tm1Imx/J
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • following S. aureus infection   (MGI Ref ID J:125570)
  • immune system phenotype
  • decreased circulating interleukin-18 level
    • 24 hours following S. aureus infection   (MGI Ref ID J:125570)
  • decreased circulating interleukin-6 level
    • 4 and 24 hours following S. aureus infection   (MGI Ref ID J:125570)
  • decreased interleukin-6 secretion
    • in spleen cells stimulated with formalin-killed S. aureus infection for 48 hours   (MGI Ref ID J:125570)
    • within wound fluids on days 1, 3, 5, 10, and 14 of wound healing   (MGI Ref ID J:148779)
  • decreased tumor necrosis factor secretion
    • in spleen cells stimulated with formalin-killed S. aureus infection   (MGI Ref ID J:125570)
  • increased circulating interleukin-1 beta level
    • 96 hours following S. aureus infection   (MGI Ref ID J:125570)
  • increased circulating interleukin-18 level
    • 96 hours following S. aureus infection   (MGI Ref ID J:125570)
  • increased susceptibility to bacterial infection
    • following S. aureus infection, mice exhibit severe septicemia, increased weight loss, increased frequency and severity of arthritis, increased bacterial load, and decreased survival compared with wild-type mice   (MGI Ref ID J:125570)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • following S. aureus infection   (MGI Ref ID J:125570)
  • increased susceptibility to induced arthritis
    • following S. aureus infection   (MGI Ref ID J:125570)
  • sepsis
    • following S. aureus infection   (MGI Ref ID J:125570)
  • homeostasis/metabolism phenotype
  • abnormal vascular wound healing
    • following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice   (MGI Ref ID J:107324)
    • neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow   (MGI Ref ID J:107324)
  • decreased circulating interleukin-18 level
    • 24 hours following S. aureus infection   (MGI Ref ID J:125570)
  • decreased circulating interleukin-6 level
    • 4 and 24 hours following S. aureus infection   (MGI Ref ID J:125570)
  • decreased transforming growth factor level
    • within wound fluids on day 1 of wound healing   (MGI Ref ID J:148779)
  • enhanced wound healing
    • after wound healing, mice exhibit decreased scar width and depth compared with wild-type mice   (MGI Ref ID J:148779)
    • deep tissue wounds exhibit 3-fold less fibrosis compared to in wild-type mice   (MGI Ref ID J:148779)
    • however, mice exhibit normal cellular infiltration and tensile strength of skin wounds   (MGI Ref ID J:148779)
  • impaired glucose tolerance
    • following glucose challenge, older mice exhibit impaired plasma glucose elimination compared with wild-type mice   (MGI Ref ID J:108634)
  • increased circulating insulin level
    • 2-fold in 9 and 11 month old mice   (MGI Ref ID J:108634)
  • increased circulating insulin-like growth factor I level
    • in older mice   (MGI Ref ID J:108634)
  • increased circulating interleukin-1 beta level
    • 96 hours following S. aureus infection   (MGI Ref ID J:125570)
  • increased circulating interleukin-18 level
    • 96 hours following S. aureus infection   (MGI Ref ID J:125570)
  • increased circulating leptin level
    • 2-fold in 9 and 11 month old mice   (MGI Ref ID J:108634)
  • increased respiratory quotient
    • during the first half of the dark cycle   (MGI Ref ID J:108634)
  • insulin resistance
    • in older mice   (MGI Ref ID J:108634)
  • growth/size/body phenotype
  • abnormal lean body mass
    • older mice exhibit a decrease in percentage lean body mass but an increase in absolute lean body mass compared with wild-type mice   (MGI Ref ID J:108634)
  • increased body length
    • in older mice   (MGI Ref ID J:108634)
  • increased body weight
    • after 5 to 6 months   (MGI Ref ID J:108634)
    • increased body mass index
      • in older mice   (MGI Ref ID J:108634)
  • increased growth rate
    • in older mice   (MGI Ref ID J:108634)
  • increased percent body fat
    • in older mice   (MGI Ref ID J:108634)
  • increased susceptibility to age related obesity   (MGI Ref ID J:108634)
  • increased total body fat amount
    • 2-fold at 9 months of age   (MGI Ref ID J:108634)
    • however, mice exhibit normal body fat at 4 months of age   (MGI Ref ID J:108634)
  • weight loss
    • following S. aureus infection   (MGI Ref ID J:125570)
  • adipose tissue phenotype
  • increased abdominal fat pad weight
    • at 19 months, intra-abdominal fat mass is increased 1.5- to 1.7-fold compared with wild-type mice   (MGI Ref ID J:108634)
  • increased gonadal fat pad weight
    • in older mice   (MGI Ref ID J:108634)
  • increased inguinal fat pad weight
    • in older mice   (MGI Ref ID J:108634)
  • increased mesenteric fat pad weight
    • in older mice   (MGI Ref ID J:108634)
  • increased percent body fat
    • in older mice   (MGI Ref ID J:108634)
  • increased retroperitoneal fat pad weight
    • in older mice   (MGI Ref ID J:108634)
  • increased total body fat amount
    • 2-fold at 9 months of age   (MGI Ref ID J:108634)
    • however, mice exhibit normal body fat at 4 months of age   (MGI Ref ID J:108634)
  • skeleton phenotype
  • increased susceptibility to induced arthritis
    • following S. aureus infection   (MGI Ref ID J:125570)
  • behavior/neurological phenotype
  • abnormal food intake
    • preobese mice exhibit mild leptin resistance compared with wild-type mice   (MGI Ref ID J:108634)
  • decreased anxiety-related response
    • mice exhibit reduced latency to drink in a novelty-induced hypophagia test compared with wild-type mice   (MGI Ref ID J:150445)
    • mice spend more time in the open arms of an elevated plus maze compared with wild-type mice   (MGI Ref ID J:150445)
    • mice exhibit increased latency to enter into the dark chamber in a light/dark test compared with wild-type mice   (MGI Ref ID J:150445)
  • enhanced contextual conditioning behavior   (MGI Ref ID J:150445)
  • hypoactivity
    • during the dark phase at 4 months   (MGI Ref ID J:108634)
  • liver/biliary system phenotype
  • increased liver weight
    • in older mice   (MGI Ref ID J:108634)
  • cardiovascular system phenotype
  • abnormal vascular wound healing
    • following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice   (MGI Ref ID J:107324)
    • neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow   (MGI Ref ID J:107324)
  • nervous system phenotype
  • abnormal nervous system electrophysiology
    • following administration of kainate, Purkinje cells fail to exhibit an increase in firing rate unlike wild-type cells   (MGI Ref ID J:145169)

Il1r1tm1Imx/Il1r1tm1Imx

        B6.129S7-Il1r1tm1Imx
  • immune system phenotype
  • *normal* immune system phenotype
    • mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice   (MGI Ref ID J:173245)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Il1r1tm1Imx/Il1r1tm1Imx

        involves: 129 * C57BL/6
  • homeostasis/metabolism phenotype
  • decreased circulating interleukin-6 level
    • no IL-6 is detected in sera of mice injected with IL-1alpha   (MGI Ref ID J:43088)
  • immune system phenotype
  • decreased circulating interleukin-6 level
    • no IL-6 is detected in sera of mice injected with IL-1alpha   (MGI Ref ID J:43088)
  • increased susceptibility to bacterial infection
    • mice have 3 log greater bacterial penetration of the dental pulp eight days after bacterial innoculation   (MGI Ref ID J:58851)
  • osteomyelitis
    • osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp   (MGI Ref ID J:58851)
    • the osteolytic lesions continue to be larger for at least 38 days post inoculation   (MGI Ref ID J:58851)
  • cellular phenotype
  • necrosis
    • mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation   (MGI Ref ID J:58851)
    • complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation   (MGI Ref ID J:58851)
  • skeleton phenotype
  • increased bone resorption
    • there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp   (MGI Ref ID J:58851)
    • osteoclast activity of the molars is 2-fold higher than in wild-types 7 days after bacterial inoculation   (MGI Ref ID J:58851)
  • osteomyelitis
    • osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp   (MGI Ref ID J:58851)
    • the osteolytic lesions continue to be larger for at least 38 days post inoculation   (MGI Ref ID J:58851)

Il1r1tm1Imx/Il1r1tm1Imx

        involves: 129S7/SvEvBrd
  • craniofacial phenotype
  • delayed tooth eruption
    • mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice   (MGI Ref ID J:103141)
  • immune system phenotype
  • abnormal neutrophil physiology
    • neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls   (MGI Ref ID J:113110)
  • hematopoietic system phenotype
  • abnormal neutrophil physiology
    • neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls   (MGI Ref ID J:113110)

Il1r1tm1Imx/Il1r1tm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • mice treated with IL1b, either intraperitoneally or intracerebroventricularly, fail to exhibit a decrease in social exploration, immobility, decrease in body weight, or reduced food intake compared with similarly treated wild-type mice   (MGI Ref ID J:112148)
    • pretreatment with TNFbp attenuates depressive effect of LPS unlike in similarly treated wild-type mice   (MGI Ref ID J:112148)
    • however, behavioral response to LPS treatment is normal   (MGI Ref ID J:112148)
  • decreased blood urea nitrogen level
    • following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen levels at 48 and 72 hours compared with wild-type mice   (MGI Ref ID J:112999)
  • decreased circulating creatinine level
    • following ischemic/reperfusion injury, mice exhibit reduced serum creatinine levels at 48 and 72 hours compared with wild-type mice   (MGI Ref ID J:112999)
  • decreased susceptibility to kidney reperfusion injury
    • following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen and creatinine levels at 48 and 72 hours with reduced polymorphonuclear leukocyte infiltration compared with wild-type mice   (MGI Ref ID J:112999)
    • however, tubular damage is normal   (MGI Ref ID J:112999)
  • immune system phenotype
  • abnormal neutrophil physiology
    • following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice   (MGI Ref ID J:112999)
  • decreased susceptibility to experimental autoimmune uveoretinitis
    • following reverse passive Arthus reaction to induce uveitis, mice exhibit reduced cellular infiltration into the anterior and posterior segments compared with wild-type mice   (MGI Ref ID J:115094)
  • renal/urinary system phenotype
  • decreased susceptibility to kidney reperfusion injury
    • following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen and creatinine levels at 48 and 72 hours with reduced polymorphonuclear leukocyte infiltration compared with wild-type mice   (MGI Ref ID J:112999)
    • however, tubular damage is normal   (MGI Ref ID J:112999)
  • growth/size/body phenotype
  • increased body weight
    • in some experiments   (MGI Ref ID J:112148)
  • hematopoietic system phenotype
  • abnormal neutrophil physiology
    • following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice   (MGI Ref ID J:112999)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il1r1tm1Imx related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il1r1tm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (knock-out)
Common Name(s) IL-1R1-; IL-1R-; IL-1RI KO; IL-R1-; Il1r1tm1jmx; Il1rtm1Imx; RIko;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Il1r1, interleukin 1 receptor, type I
Chromosome 1
Gene Common Name(s) CD121A; D2S1473; IL-1 receptor alpha chain; IL-1R-alpha; IL-iR; IL1R; IL1RA; Il1r-1; P80;
Molecular Note A neomycin resistance cassette replaced two exons of the gene, which encode amino acids 4 - 225 of the mature protein. [MGI Ref ID J:43088]

Genotyping

Genotyping Information

Genotyping Protocols

Il1r1tm1Imx,

Separated MCA


Il1r1tm1Imx, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Glaccum MB; Stocking KL; Charrier K; Smith JL; Willis CR; Maliszewski C ; Livingston DJ ; Peschon JJ ; Morrissey PJ. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-71. [PubMed: 9317135]  [MGI Ref ID J:43088]

Additional References

Il1r1tm1Imx related

Abcouwer SF; Norman J; Fink G; Carter G; Lustig RJ; Souba WW. 1996. Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice. Surgery 120(2):255-63; discussion 263-4. [PubMed: 8751591]  [MGI Ref ID J:114173]

Abdalla H; Srinivasan L; Shah S; Mayer-Barber KD; Sher A; Sutterwala FS; Briken V. 2012. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1beta and IL-18 secretion but not to pyroptosis. PLoS One 7(7):e40722. [PubMed: 22911706]  [MGI Ref ID J:189888]

Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70-9. [PubMed: 22201681]  [MGI Ref ID J:184390]

Allen RG; Lafuse WP; Powell ND; Webster Marketon JI; Stiner-Jones LM; Sheridan JF; Bailey MT. 2012. Stressor-Induced Increase in Microbicidal Activity of Splenic Macrophages Is Dependent upon Peroxynitrite Production. Infect Immun 80(10):3429-37. [PubMed: 22825446]  [MGI Ref ID J:187596]

Andoh T; Kishi H; Motoki K; Nakanishi K; Kuraishi Y; Muraguchi A. 2008. Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice. J Immunol 180(4):2322-8. [PubMed: 18250441]  [MGI Ref ID J:131996]

Andre R; Moggs JG; Kimber I; Rothwell NJ; Pinteaux E. 2006. Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia 53(5):477-83. [PubMed: 16358337]  [MGI Ref ID J:156138]

Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. [PubMed: 18941239]  [MGI Ref ID J:140719]

Baccarella A; Fontana MF; Chen EC; Kim CC. 2013. Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun 81(12):4431-42. [PubMed: 24042114]  [MGI Ref ID J:202330]

Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. [PubMed: 18329246]  [MGI Ref ID J:137505]

Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. [PubMed: 12122068]  [MGI Ref ID J:124246]

Basu A; Lazovic J; Krady JK; Mauger DT; Rothstein RP; Smith MB; Levison SW. 2005. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25(1):17-29. [PubMed: 15678109]  [MGI Ref ID J:105286]

Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. [PubMed: 21741932]  [MGI Ref ID J:176323]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Bluthe RM; Laye S; Michaud B; Combe C; Dantzer R; Parnet P. 2000. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12(12):4447-56. [PubMed: 11122355]  [MGI Ref ID J:112148]

Boettcher S; Ziegler P; Schmid MA; Takizawa H; van Rooijen N; Kopf M; Heikenwalder M; Manz MG. 2012. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J Immunol 188(12):5824-8. [PubMed: 22586037]  [MGI Ref ID J:188869]

Bonnet MC; Preukschat D; Welz PS; van Loo G; Ermolaeva MA; Bloch W; Haase I; Pasparakis M. 2011. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity 35(4):572-82. [PubMed: 22000287]  [MGI Ref ID J:177639]

Brinster C; Shevach EM. 2008. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J Leukoc Biol 84(2):480-7. [PubMed: 18477692]  [MGI Ref ID J:138445]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Campbell K; Gifford T; Sriramarao P. 2000. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood 95(1):263-9. [PubMed: 10607711]  [MGI Ref ID J:110254]

Bulua AC; Simon A; Maddipati R; Pelletier M; Park H; Kim KY; Sack MN; Kastner DL; Siegel RM. 2011. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208(3):519-33. [PubMed: 21282379]  [MGI Ref ID J:176847]

Bunt SK; Yang L; Sinha P; Clements VK; Leips J; Ostrand-Rosenberg S. 2007. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67(20):10019-26. [PubMed: 17942936]  [MGI Ref ID J:126013]

Cai S; Batra S; Wakamatsu N; Pacher P; Jeyaseelan S. 2012. NLRC4 inflammasome-mediated production of IL-1beta modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol 188(11):5623-35. [PubMed: 22547706]  [MGI Ref ID J:188721]

Carmi Y; Dotan S; Rider P; Kaplanov I; White MR; Baron R; Abutbul S; Huszar M; Dinarello CA; Apte RN; Voronov E. 2013. The Role of IL-1beta in the Early Tumor Cell-Induced Angiogenic Response. J Immunol 190(7):3500-9. [PubMed: 23475218]  [MGI Ref ID J:194907]

Cassel SL; Janczy JR; Bing X; Wilson SP; Olivier AK; Otero JE; Iwakura Y; Shayakhmetov DM; Bassuk AG; Abu-Amer Y; Brogden KA; Burns TL; Sutterwala FS; Ferguson PJ. 2014. Inflammasome-independent IL-1beta mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A 111(3):1072-7. [PubMed: 24395802]  [MGI Ref ID J:206468]

Ceballos-Olvera I; Sahoo M; Miller MA; Del Barrio L; Re F. 2011. Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1beta is deleterious. PLoS Pathog 7(12):e1002452. [PubMed: 22241982]  [MGI Ref ID J:183297]

Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168(4):1396-403. [PubMed: 16565512]  [MGI Ref ID J:107324]

Chamberlain J; Francis S; Brookes Z; Shaw G; Graham D; Alp NJ; Dower S; Crossman DC. 2009. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE 4(4):e5073. [PubMed: 19347044]  [MGI Ref ID J:148173]

Chamberlain J; Wheatcroft M; Arnold N; Lupton H; Crossman DC; Gunn J; Francis S. 2010. A novel mouse model of in situ stenting. Cardiovasc Res 85(1):38-44. [PubMed: 19633315]  [MGI Ref ID J:172559]

Chen CJ; Kono H; Golenbock D; Reed G; Akira S; Rock KL. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 13(7):851-6. [PubMed: 17572686]  [MGI Ref ID J:125088]

Chen CJ; Shi Y; Hearn A; Fitzgerald K; Golenbock D; Reed G; Akira S; Rock KL. 2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116(8):2262-71. [PubMed: 16886064]  [MGI Ref ID J:113110]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Chen Q; Sen G; Snapper CM. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177(9):6044-51. [PubMed: 17056530]  [MGI Ref ID J:140525]

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Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Petrasek J; Bala S; Csak T; Lippai D; Kodys K; Menashy V; Barrieau M; Min SY; Kurt-Jones EA; Szabo G. 2012. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest 122(10):3476-89. [PubMed: 22945633]  [MGI Ref ID J:191666]

Pindjakova J; Hanley SA; Duffy MM; Sutton CE; Weidhofer GA; Miller MN; Nath KA; Mills KH; Ceredig R; Griffin MD. 2012. Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction. Kidney Int 81(4):379-90. [PubMed: 21975862]  [MGI Ref ID J:196500]

Provoost S; Maes T; Pauwels NS; Vanden Berghe T; Vandenabeele P; Lambrecht BN; Joos GF; Tournoy KG. 2011. NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol 187(6):3331-7. [PubMed: 21844393]  [MGI Ref ID J:179240]

Qian J; Zhu L; Li Q; Belevych N; Chen Q; Zhao F; Herness S; Quan N. 2012. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109(30):12189-94. [PubMed: 22778412]  [MGI Ref ID J:186478]

Rad R; Brenner L; Krug A; Voland P; Mages J; Lang R; Schwendy S; Reindl W; Dossumbekova A; Ballhorn W; Wagner H; Schmid RM; Bauer S; Prinz C. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133(1):150-163.e3. [PubMed: 17631139]  [MGI Ref ID J:128297]

Rankin AL; Mumm JB; Murphy E; Turner S; Yu N; McClanahan TK; Bourne PA; Pierce RH; Kastelein R; Pflanz S. 2010. IL-33 induces IL-13-dependent cutaneous fibrosis. J Immunol 184(3):1526-35. [PubMed: 20042577]  [MGI Ref ID J:159528]

Rijneveld AW; Florquin S; Branger J; Speelman P; Van Deventer SJ; van Der Poll T. 2001. Tnf-alpha compensates for the impaired host defense of il-1 type i receptor-deficient mice during pneumococcal pneumonia. J Immunol 167(9):5240-6. [PubMed: 11673538]  [MGI Ref ID J:72672]

Robinson KM; Choi SM; McHugh KJ; Mandalapu S; Enelow RI; Kolls JK; Alcorn JF. 2013. Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1beta production in mice. J Immunol 191(10):5153-9. [PubMed: 24089191]  [MGI Ref ID J:206343]

Rosenzweig HL; Martin TM; Planck SR; Galster K; Jann MM; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol 84(2):529-36. [PubMed: 18495787]  [MGI Ref ID J:138433]

Russo BC; Horzempa J; O'Dee DM; Schmitt DM; Brown MJ; Carlson PE Jr; Xavier RJ; Nau GJ. 2011. A Francisella tularensis Locus Required for Spermine Responsiveness Is Necessary for Virulence. Infect Immun 79(9):3665-76. [PubMed: 21670171]  [MGI Ref ID J:175717]

Russo HM; Wickenheiser KJ; Luo W; Ohman MK; Franchi L; Wright AP; Bodary PF; Nunez G; Eitzman DT. 2010. P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue. Circ Res 107(3):388-97. [PubMed: 20558823]  [MGI Ref ID J:175038]

Sanders CJ; Moore DA 3rd; Williams IR; Gewirtz AT. 2008. Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol 180(11):7184-92. [PubMed: 18490717]  [MGI Ref ID J:136347]

Schepers K; Pietras EM; Reynaud D; Flach J; Binnewies M; Garg T; Wagers AJ; Hsiao EC; Passegue E. 2013. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 13(3):285-99. [PubMed: 23850243]  [MGI Ref ID J:201668]

Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. [PubMed: 17229673]  [MGI Ref ID J:121446]

Schmidt MA; Wisor JP. 2012. Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence. Neurosci Lett 513(2):209-13. [PubMed: 22387068]  [MGI Ref ID J:182682]

Schnyder-Candrian S; Quesniaux VF; Di Padova F; Maillet I; Noulin N; Couillin I; Moser R; Erard F; Vargaftig BB; Ryffel B; Schnyder B. 2005. Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol 175(1):262-9. [PubMed: 15972657]  [MGI Ref ID J:100580]

Schultz MJ; Rijneveld AW; Florquin S; Edwards CK; Dinarello CA; van der Poll T. 2002. Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol 282(2):L285-90. [PubMed: 11792633]  [MGI Ref ID J:108270]

Sewnath ME; Van Der Poll T; Ten Kate FJ; Van Noorden CJ; Gouma DJ. 2002. Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin. Hepatology 35(1):149-58. [PubMed: 11786971]  [MGI Ref ID J:105837]

Shaftel SS; Carlson TJ; Olschowka JA; Kyrkanides S; Matousek SB; O'Banion MK. 2007. Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci 27(35):9301-9. [PubMed: 17728444]  [MGI Ref ID J:124945]

Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. 2007. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595-604. [PubMed: 17549256]  [MGI Ref ID J:122022]

Sheahan T; Morrison TE; Funkhouser W; Uematsu S; Akira S; Baric RS; Heise MT. 2008. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog 4(12):e1000240. [PubMed: 19079579]  [MGI Ref ID J:162707]

Shirazi R; Palsdottir V; Collander J; Anesten F; Vogel H; Langlet F; Jaschke A; Schurmann A; Prevot V; Shao R; Jansson JO; Skibicka KP. 2013. Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc Natl Acad Sci U S A 110(40):16199-16204. [PubMed: 24048027]  [MGI Ref ID J:201127]

Simsa-Maziel S; Zaretsky J; Reich A; Koren Y; Shahar R; Monsonego-Ornan E. 2013. IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab 305(1):E15-21. [PubMed: 23592480]  [MGI Ref ID J:199202]

Skyberg JA; Thornburg T; Kochetkova I; Layton W; Callis G; Rollins MF; Riccardi C; Becker T; Golden S; Pascual DW. 2012. IFN-gamma-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis. J Leukoc Biol 92(2):375-87. [PubMed: 22636321]  [MGI Ref ID J:186167]

Su SB; Silver PB; Grajewski RS; Agarwal RK; Tang J; Chan CC; Caspi RR. 2005. Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 175(10):6303-10. [PubMed: 16272281]  [MGI Ref ID J:119346]

Sun Y; Chandra J; Mukherjee P; Szczotka-Flynn L; Ghannoum MA; Pearlman E. 2010. A murine model of contact lens-associated fusarium keratitis. Invest Ophthalmol Vis Sci 51(3):1511-6. [PubMed: 19875664]  [MGI Ref ID J:160415]

Tanikawa T; Wilke CM; Kryczek I; Chen GY; Kao J; Nunez G; Zou W. 2012. Interleukin-10 ablation promotes tumor development, growth, and metastasis. Cancer Res 72(2):420-9. [PubMed: 22123924]  [MGI Ref ID J:181148]

Tarallo V; Hirano Y; Gelfand BD; Dridi S; Kerur N; Kim Y; Cho WG; Kaneko H; Fowler BJ; Bogdanovich S; Albuquerque RJ; Hauswirth WW; Chiodo VA; Kugel JF; Goodrich JA; Ponicsan SL; Chaudhuri G; Murphy MP; Dunaief JL; Ambati BK; Ogura Y; Yoo JW; Lee DK; Provost P; Hinton DR; Nunez G; Baffi JZ; Kleinman ME; Ambati J. 2012. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149(4):847-59. [PubMed: 22541070]  [MGI Ref ID J:186198]

Tchaptchet S; Gumenscheimer M; Kalis C; Freudenberg N; Holscher C; Kirschning CJ; Lamers M; Galanos C; Freudenberg MA. 2012. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS One 7(6):e39155. [PubMed: 22745710]  [MGI Ref ID J:187937]

Thomay AA; Daley JM; Sabo E; Worth PJ; Shelton LJ; Harty MW; Reichner JS; Albina JE. 2009. Disruption of interleukin-1 signaling improves the quality of wound healing. Am J Pathol 174(6):2129-36. [PubMed: 19389930]  [MGI Ref ID J:148779]

Thompson AL; Johnson BT; Sempowski GD; Gunn MD; Hou B; Defranco AL; Staats HF. 2012. Maximal Adjuvant Activity of Nasally Delivered IL-1alpha Requires Adjuvant-Responsive CD11c+ Cells and Does Not Correlate with Adjuvant-Induced In Vivo Cytokine Production. J Immunol 188(6):2834-46. [PubMed: 22345651]  [MGI Ref ID J:181839]

Togbe D; Aurore G; Noulin N; Quesniaux VF; Schnyder-Candrian S; Schnyder B; Vasseur V; Akira S; Hoebe K; Beutler B; Ryffel B; Couillin I. 2006. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab Invest 86(11):1126-35. [PubMed: 16983331]  [MGI Ref ID J:114842]

Touzani O; Boutin H; LeFeuvre R; Parker L; Miller A; Luheshi G; Rothwell N. 2002. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J Neurosci 22(1):38-43. [PubMed: 11756486]  [MGI Ref ID J:112422]

Turnbull AV; Prehar S; Kennedy AR; Little RA; Hopkins SJ. 2003. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 144(5):1894-906. [PubMed: 12697697]  [MGI Ref ID J:115710]

Ueda Y; Cain DW; Kuraoka M; Kondo M; Kelsoe G. 2009. IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. J Immunol 182(10):6477-84. [PubMed: 19414802]  [MGI Ref ID J:150293]

Ulland TK; Janowski AM; Buchan BW; Faron M; Cassel SL; Jones BD; Sutterwala FS. 2013. Francisella tularensis Live Vaccine Strain Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation. Infect Immun 81(1):201-8. [PubMed: 23115038]  [MGI Ref ID J:190664]

Veliz Rodriguez T; Moalli F; Polentarutti N; Paroni M; Bonavita E; Anselmo A; Nebuloni M; Mantero S; Jaillon S; Bragonzi A; Mantovani A; Riva F; Garlanda C. 2012. Role of Toll Interleukin-1 Receptor (IL-1R) 8, a Negative Regulator of IL-1R/Toll-Like Receptor Signaling, in Resistance to Acute Pseudomonas aeruginosa Lung Infection. Infect Immun 80(1):100-9. [PubMed: 22025515]  [MGI Ref ID J:178959]

Vincent JA; Mohr S. 2007. Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56(1):224-30. [PubMed: 17192486]  [MGI Ref ID J:121933]

Vonarbourg C; Mortha A; Bui VL; Hernandez PP; Kiss EA; Hoyler T; Flach M; Bengsch B; Thimme R; Holscher C; Honig M; Pannicke U; Schwarz K; Ware CF; Finke D; Diefenbach A. 2010. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 33(5):736-51. [PubMed: 21093318]  [MGI Ref ID J:167005]

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Wohleb ES; Patterson JM; Sharma V; Quan N; Godbout JP; Sheridan JF. 2014. Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior. J Neurosci 34(7):2583-91. [PubMed: 24523548]  [MGI Ref ID J:206939]

Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain may be maintained by homozygous sibling matings. Expected coat color from breeding is black.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $177.00Female or MaleHomozygous for Il1r1tm1Imx  
Price per Pair (US dollars $)Pair Genotype
$354.00Homozygous for Il1r1tm1Imx x Homozygous for Il1r1tm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $230.10Female or MaleHomozygous for Il1r1tm1Imx  
Price per Pair (US dollars $)Pair Genotype
$460.20Homozygous for Il1r1tm1Imx x Homozygous for Il1r1tm1Imx  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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