Strain Name:

B6.129S7-Tnfrsf1btm1Imx/J

Stock Number:

003246

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names Tnfr2    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2)
 
Donating InvestigatorDr. Jacques Peschon,   Amgen

Description
Mice homozygous for a Tnfrsf1btm1Imx targeted mutation (formerly Tnfr2tm1Imx, p75 deficient) are viable and fertile. T cells from homozygous mutant mice display defects in activation induced cell death in vitro and dramatically elevated levels of circulating Tnf following systemic challenge with LPS. Pulmonary neutrophil influx is exacerbated in p75 deficient mice in a model of hypersensitivity pneumonitis.

Development
The p75 mutation was made by homologous recombination in the 129/SvEv derived AB1 ES cell line using a gene replacement vector in which a 1 kb Kas1-BamH1 fragment was replaced with a PGKneo cassette. The resulting null mutation results in a deletion of amino acids 3 - 26. This strain was generated on a 129/SvEv background and is currently at N5 on a C57BL/6 background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tnfrsf1btm1Imx allele
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
View Strains carrying   Tnfrsf1btm1Imx     (1 strain)

Strains carrying other alleles of Tnfrsf1b
002620   B6.129S2-Tnfrsf1btm1Mwm/J
View Strains carrying other alleles of Tnfrsf1b     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Hyperlipidemia, Familial Combined; FCHL
Hypertension, Essential
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tnfrsf1btm1Imx/Tnfrsf1btm1Imx

        B6.129S7-Tnfrsf1btm1Imx
  • skeleton phenotype
  • *normal* skeleton phenotype
    • no increase in bone mineral density   (MGI Ref ID J:135519)
  • respiratory system phenotype
  • *normal* respiratory system phenotype
    • display a rapid increase in peak inspiratory pressure when exposed to high stretch ventilation, as is seen in controls   (MGI Ref ID J:143836)
    • abnormal lung compliance   (MGI Ref ID J:143836)
  • homeostasis/metabolism phenotype
  • abnormal blood gas level
    • decreased arterial pO2 after 2 hours of high stretch ventilation   (MGI Ref ID J:143836)
    • increased arterial pCO2 after 2 hours of high stretch ventilation   (MGI Ref ID J:143836)
  • cardiovascular system phenotype
  • decreased systemic arterial blood pressure
    • drops below 45mm Hg by 70 minutes of high stretch ventilation whereas controls require 90 minutes   (MGI Ref ID J:143836)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tnfrsf1btm1Imx/Tnfrsf1btm1Imx

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells significantly increased relative to controls after epileptic stimulation   (MGI Ref ID J:112713)
  • increased circulating tumor necrosis factor level
    • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • increased inflammatory response
    • increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control   (MGI Ref ID J:45147)
    • lung inflammation
      • increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • normal recovery after superficial injury causes an increased trans-epidermal water loss   (MGI Ref ID J:59056)
    • decreased susceptibility to dopaminergic neuron neurotoxicity
      • 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
    • increased circulating tumor necrosis factor level
      • two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered   (MGI Ref ID J:45147)
  • nervous system phenotype
  • abnormal glutamate-mediated receptor currents
    • increased glutamate currents   (MGI Ref ID J:152590)
  • abnormal microglial cell morphology
    • numbers of microglial cells significantly increased relative to controls after epileptic stimulation   (MGI Ref ID J:112713)
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
  • tumorigenesis
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • respiratory system phenotype
  • lung inflammation
    • increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid   (MGI Ref ID J:120174)
  • hematopoietic system phenotype
  • abnormal microglial cell morphology
    • numbers of microglial cells significantly increased relative to controls after epileptic stimulation   (MGI Ref ID J:112713)
  • integument phenotype
  • increased skin papilloma incidence
    • development after DMPA/TPA treatment is reduced   (MGI Ref ID J:89088)
  • cellular phenotype
  • decreased susceptibility to dopaminergic neuron neurotoxicity
    • 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)   (MGI Ref ID J:78637)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tnfrsf1btm1Imx related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tnfrsf1btm1Imx
Allele Name targeted mutation 1, Immunex Research and Development Corporation
Allele Type Targeted (Null/Knockout)
Common Name(s) TNFR2-; TNFRII-; TNFbeta ko; Tnfrsf1btm1Imx; p75 KO; p75-;
Mutation Made ByDr. Jacques Peschon,   Amgen
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Tnfrsf1b, tumor necrosis factor receptor superfamily, member 1b
Chromosome 4
Gene Common Name(s) CD120b; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-alphaR2; TNFBR; TNFR1B; TNFR2; TNFR80; TNFRII; TNFalpha-R2; Tnfr-1; Tnfr2; p75; p75 TNFR; p75TNFR; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note A PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. [MGI Ref ID J:45147]

Genotyping

Genotyping Information

Genotyping Protocols

Tnfrsf1btm1Imx, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. [PubMed: 9551933]  [MGI Ref ID J:45147]

Additional References

Arnett HA; Mason J; Marino M; Suzuki K; Matsushima GK; Ting JP. 2001. TNFalpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4(11):1116-22. [PubMed: 11600888]  [MGI Ref ID J:72695]

Tnfrsf1btm1Imx related

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Allam R; Darisipudi MN; Rupanagudi KV; Lichtnekert J; Tschopp J; Anders HJ. 2011. Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1{beta} Secretion by Activating the NLRP3 Inflammasome. J Immunol 186(5):2714-8. [PubMed: 21278344]  [MGI Ref ID J:169383]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Arnott CH; Scott KA; Moore RJ; Robinson SC; Thompson RG; Balkwill FR. 2004. Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene 23(10):1902-10. [PubMed: 14661063]  [MGI Ref ID J:89088]

Artis D; Humphreys NE; Bancroft AJ; Rothwell NJ; Potten CS; Grencis RK. 1999. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190(7):953-62. [PubMed: 10510085]  [MGI Ref ID J:115088]

Balosso S; Ravizza T; Pierucci M; Calcagno E; Invernizzi R; Di Giovanni G; Esposito E; Vezzani A. 2009. Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: implications for seizure susceptibility. Neuroscience 161(1):293-300. [PubMed: 19285115]  [MGI Ref ID J:152590]

Baseta JG; Stutman O. 2000. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. J Immunol 165(10):5621-30. [PubMed: 11067918]  [MGI Ref ID J:112282]

Beamer CA; Holian A. 2007. Antigen-presenting cell population dynamics during murine silicosis. Am J Respir Cell Mol Biol 37(6):729-38. [PubMed: 17641296]  [MGI Ref ID J:141645]

Belisle SE; Tisoncik JR; Korth MJ; Carter VS; Proll SC; Swayne DE; Pantin-Jackwood M; Tumpey TM; Katze MG. 2010. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 84(24):12576-88. [PubMed: 20926563]  [MGI Ref ID J:166538]

Berta T; Park CK; Xu ZZ; Xie RG; Liu T; Lu N; Liu YC; Ji RR. 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest 124(3):1173-86. [PubMed: 24531553]  [MGI Ref ID J:209726]

Bertok S; Wilson MR; Dorr AD; Dokpesi JO; O'Dea KP; Marczin N; Takata M. 2011. Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice. Am J Physiol Lung Cell Mol Physiol 300(5):L781-9. [PubMed: 21378027]  [MGI Ref ID J:174247]

Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. [PubMed: 18192488]  [MGI Ref ID J:134193]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Borges VM; Vandivier RW; McPhillips KA; Kench JA; Morimoto K; Groshong SD; Richens TR; Graham BB; Muldrow AM; Van Heule L; Henson PM; Janssen WJ. 2009. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol 297(4):L586-95. [PubMed: 19648283]  [MGI Ref ID J:154222]

Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653]  [MGI Ref ID J:115094]

Broide DH; Stachnick G; Castaneda D; Nayar J; Sriramarao P. 2001. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol 24(3):304-11. [PubMed: 11245629]  [MGI Ref ID J:114289]

Bruce AJ; Boling W; Kindy MS; Peschon J; Kraemer PJ; Carpenter MK; Holtsberg FW; Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2(7):788-94. [PubMed: 8673925]  [MGI Ref ID J:33864]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Chan FK; Shisler J; Bixby JG; Felices M; Zheng L; Appel M; Orenstein J; Moss B; Lenardo MJ. 2003. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem 278(51):51613-21. [PubMed: 14532286]  [MGI Ref ID J:89973]

Chandrasekharan UM; Siemionow M; Unsal M; Yang L; Poptic E; Bohn J; Ozer K; Zhou Z; Howe PH; Penn M; DiCorleto PE. 2007. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood 109(5):1938-44. [PubMed: 17068152]  [MGI Ref ID J:145363]

Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943]  [MGI Ref ID J:58851]

Chen MC; Mudge CS; Klumpp DJ. 2006. Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis. Am J Physiol Renal Physiol 291(4):F741-9. [PubMed: 16622179]  [MGI Ref ID J:144913]

Chen SE; Gerken E; Zhang Y; Zhan M; Mohan RK; Li AS; Reid MB; Li YP. 2005. Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle. Am J Physiol Cell Physiol 289(5):C1179-87. [PubMed: 16079187]  [MGI Ref ID J:104990]

Chen SE; Jin B; Li YP. 2007. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292(5):C1660-71. [PubMed: 17151142]  [MGI Ref ID J:125884]

Chopra M; Lang I; Salzmann S; Pachel C; Kraus S; Bauerlein CA; Brede C; Garrote AL; Mattenheimer K; Ritz M; Schwinn S; Graf C; Schafer V; Frantz S; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One 8(9):e75737. [PubMed: 24098720]  [MGI Ref ID J:207733]

Chopra M; Riedel SS; Biehl M; Krieger S; von Krosigk V; Bauerlein CA; Brede C; Jordan Garrote AL; Kraus S; Schafer V; Ritz M; Mattenheimer K; Degla A; Mottok A; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6):1296-303. [PubMed: 23385062]  [MGI Ref ID J:198326]

Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. [PubMed: 18931327]  [MGI Ref ID J:159269]

Cliffe LJ; Potten CS; Booth CE; Grencis RK. 2007. An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection. Infect Immun 75(4):1556-64. [PubMed: 17242061]  [MGI Ref ID J:119507]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Cowley SC; Sedgwick JD; Elkins KL. 2007. Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth. J Immunol 179(11):7709-19. [PubMed: 18025217]  [MGI Ref ID J:155094]

Crowe CR; Chen K; Pociask DA; Alcorn JF; Krivich C; Enelow RI; Ross TM; Witztum JL; Kolls JK. 2009. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol 183(8):5301-10. [PubMed: 19783685]  [MGI Ref ID J:153826]

Cusson N; Oikemus S; Kilpatrick ED; Cunningham L; Kelliher M. 2002. The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 196(1):15-26. [PubMed: 12093867]  [MGI Ref ID J:120699]

Deepe GS Jr; Buesing WR. 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immunol 188(1):334-44. [PubMed: 22102723]  [MGI Ref ID J:180361]

Di Giuseppe M; Gambelli F; Hoyle GW; Lungarella G; Studer SM; Richards T; Yousem S; McCurry K; Dauber J; Kaminski N; Leikauf G; Ortiz LA. 2009. Systemic inhibition of NF-kappaB activation protects from silicosis. PLoS One 4(5):e5689. [PubMed: 19479048]  [MGI Ref ID J:149316]

Edelblum KL; Goettel JA; Koyama T; McElroy SJ; Yan F; Polk DB. 2008. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem 283(43):29485-94. [PubMed: 18713739]  [MGI Ref ID J:142557]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Elizur A; Adair-Kirk TL; Kelley DG; Griffin GL; Demello DE; Senior RM. 2008. Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine. Am J Respir Cell Mol Biol 38(1):8-15. [PubMed: 17673686]  [MGI Ref ID J:143000]

Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114(1):71-7. [PubMed: 10620118]  [MGI Ref ID J:127060]

Feng Y; Teitelbaum DH. 2012. Epidermal growth factor/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 302(2):G236-49. [PubMed: 22075779]  [MGI Ref ID J:183319]

Feng Y; Teitelbaum DH. 2013. Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J Physiol 591(Pt 15):3709-23. [PubMed: 23753529]  [MGI Ref ID J:212137]

Fenger C; Drojdahl N; Wirenfeldt M; Sylvest L; Jorgensen OS; Meldgaard M; Lambertsen KL; Finsen B. 2006. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia 54(6):591-605. [PubMed: 16927297]  [MGI Ref ID J:156117]

Flaherty MP; Guo Y; Tiwari S; Rezazadeh A; Hunt G; Sanganalmath SK; Tang XL; Bolli R; Dawn B. 2008. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol 45(6):735-41. [PubMed: 18824172]  [MGI Ref ID J:143321]

Fromm PD; Kling J; Mack M; Sedgwick JD; Korner H. 2012. Loss of TNF signaling facilitates the development of a novel Ly-6C(low) macrophage population permissive for Leishmania major infection. J Immunol 188(12):6258-66. [PubMed: 22615203]  [MGI Ref ID J:188958]

Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459]  [MGI Ref ID J:126245]

Fujii T; Kitaura H; Kimura K; Hakami ZW; Takano-Yamamoto T. 2012. IL-4 inhibits TNF-alpha-mediated osteoclast formation by inhibition of RANKL expression in TNF-alpha-activated stromal cells and direct inhibition of TNF-alpha-activated osteoclast precursors via a T-cell-independent mechanism in vivo. Bone 51(4):771-80. [PubMed: 22776139]  [MGI Ref ID J:192396]

Geis C; Graulich M; Wissmann A; Hagenacker T; Thomale J; Sommer C; Schafers M. 2010. Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience 169(1):463-74. [PubMed: 20417692]  [MGI Ref ID J:165239]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Cruceta J; Graves BD; Einhorn TA. 2001. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169(3):285-94. [PubMed: 11455125]  [MGI Ref ID J:70467]

Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Tsay A; Fitch J; Barnes GL; Graves DT; Einhorn TA. 2003. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 18(9):1584-92. [PubMed: 12968667]  [MGI Ref ID J:111507]

Goluszko E; Deng C; Poussin MA; Christadoss P. 2002. Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis. J Neuroimmunol 122(1-2):85-93. [PubMed: 11777546]  [MGI Ref ID J:102961]

Goretsky T; Dirisina R; Sinh P; Mittal N; Managlia E; Williams DB; Posca D; Ryu H; Katzman RB; Barrett TA. 2012. p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD. Am J Pathol 181(4):1306-15. [PubMed: 22863952]  [MGI Ref ID J:188612]

Grdina DJ; Murley JS; Miller RC; Mauceri HJ; Sutton HG; Li JJ; Woloschak GE; Weichselbaum RR. 2013. A survivin-associated adaptive response in radiation therapy. Cancer Res 73(14):4418-28. [PubMed: 23651635]  [MGI Ref ID J:199011]

Guevara Patino JA; Ivanov VN; Lacy E; Elkon KB; Marino MW; Nikolic-Zugic J. 2000. TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. J Immunol 164(4):1689-94. [PubMed: 10657611]  [MGI Ref ID J:60398]

Guma M; Stepniak D; Shaked H; Spehlmann ME; Shenouda S; Cheroutre H; Vicente-Suarez I; Eckmann L; Kagnoff MF; Karin M. 2011. Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med 208(9):1889-900. [PubMed: 21825016]  [MGI Ref ID J:177595]

Guo G; Morrissey J; McCracken R; Tolley T; Liapis H; Klahr S. 2001. Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis. Am J Physiol Renal Physiol 280(5):F777-85. [PubMed: 11292619]  [MGI Ref ID J:69294]

Harrison-Findik DD; Klein E; Evans J; Gollan J. 2009. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-{alpha} signaling. Am J Physiol Gastrointest Liver Physiol 296(1):G112-8. [PubMed: 19008338]  [MGI Ref ID J:143085]

He S; Liang Y; Shao F; Wang X. 2011. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 108(50):20054-9. [PubMed: 22123964]  [MGI Ref ID J:180434]

Hill GR; Teshima T; Rebel VI; Krijanovski OI; Cooke KR; Brinson YS; Ferrara JL. 2000. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol 164(2):656-63. [PubMed: 10623807]  [MGI Ref ID J:59298]

Huang L; Zhang R; Wu J; Chen J; Grosjean F; Satlin LH; Klein JD; Sands JM; Striker GE; Tan J; Zheng F. 2011. Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-alpha and its receptor 1. Kidney Int 79(6):613-23. [PubMed: 21150875]  [MGI Ref ID J:186880]

Iizuka K; Chaplin DD; Wang Y; Wu Q; Pegg LE; Yokoyama WM; Fu YX. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci U S A 96(11):6336-40. [PubMed: 10339588]  [MGI Ref ID J:55470]

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Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJ; Bonde S; Kokaia Z; Jacobsen SE; Lindvall O. 2006. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26(38):9703-12. [PubMed: 16988041]  [MGI Ref ID J:112713]

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Tomita K; Tamiya G; Ando S; Ohsumi K; Chiyo T; Mizutani A; Kitamura N; Toda K; Kaneko T; Horie Y; Han JY; Kato S; Shimoda M; Oike Y; Tomizawa M; Makino S; Ohkura T; Saito H; Kumagai N; Nagata H; Ishii H; Hibi T. 2006. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 55(3):415-24. [PubMed: 16174657]  [MGI Ref ID J:135782]

Turner SJ; La Gruta NL; Stambas J; Diaz G; Doherty PC. 2004. Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells. Proc Natl Acad Sci U S A 101(10):3545-50. [PubMed: 14993609]  [MGI Ref ID J:90265]

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Uysal KT; Wiesbrock SM; Marino MW; Hotamisligil GS. 1997. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389(6651):610-4. [PubMed: 9335502]  [MGI Ref ID J:43280]

Valerio A; Cardile A; Cozzi V; Bracale R; Tedesco L; Pisconti A; Palomba L; Cantoni O; Clementi E; Moncada S; Carruba MO; Nisoli E. 2006. TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest 116(10):2791-8. [PubMed: 16981010]  [MGI Ref ID J:115008]

Varanasi V; Avanesyan L; Schumann DM; Chervonsky AV. 2012. Cytotoxic mechanisms employed by mouse t cells to destroy pancreatic beta-cells. Diabetes 61(11):2862-70. [PubMed: 22773667]  [MGI Ref ID J:190161]

Venkatesh D; Ernandez T; Rosetti F; Batal I; Cullere X; Luscinskas FW; Zhang Y; Stavrakis G; Garcia-Cardena G; Horwitz BH; Mayadas TN. 2013. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment. Immunity 38(5):1025-37. [PubMed: 23623383]  [MGI Ref ID J:203156]

Vicente R; Coma M; Busquets S; Moore-Carrasco R; Lopez-Soriano FJ; Argiles JM; Felipe A. 2004. The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways. FEBS Lett 572(1-3):189-94. [PubMed: 15304346]  [MGI Ref ID J:119328]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

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Waldner MJ; Wirtz S; Jefremow A; Warntjen M; Neufert C; Atreya R; Becker C; Weigmann B; Vieth M; Rose-John S; Neurath MF. 2010. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med 207(13):2855-68. [PubMed: 21098094]  [MGI Ref ID J:176868]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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