Strain Name:

STOCK Tg(Trp53A135V)L3Ber/J

Stock Number:

003262

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Tg(Trp53A135V)2Ber/J    (Changed: 15-DEC-04 )
Type Mutant Stock; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF?+2
Generation Definitions
 
Donating InvestigatorDr. Alan Bernstein,   Canadian Institutes of Health Research

Important Note
This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.

Description
Mice homozygous for the (Trp53A135V)2Ber transgene are viable and fertile, but show a high incidence of tumors, particularly lung adenocarcinomas, osteosarcomas, and lymphomas. This strain may serve as a model for Li-Fraumeni syndrome.

Related Strains

Strains carrying   Gnat2cpfl3 allele
003072   ALS/LtJ
006795   B6.Cg-Gnat2cpfl3/Boc
006180   CD10/JlsJ
005052   PN/nBSwUmabJ
002746   SENCARA/PtJ
002747   SENCARB/PtJ
002748   SENCARC/PtJ
006135   STOCK Sgk3fz-ica/McirJ
003773   STOCK Tg(CAG-ECFP)CK6Nagy/J
005645   STOCK Tg(CAG-mRFP1)1F1Hadj/J
004623   STOCK Tg(Fos-lacZ)34Efu/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
View Strains carrying   Gnat2cpfl3     (14 strains)

View Strains carrying other alleles of Trp53     (25 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Achromatopsia 4; ACHM4   (GNAT2)
- Potential model based on transgenic expression of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Adrenocortical Carcinoma, Hereditary; ADCC   (TP53)
Basal Cell Carcinoma, Susceptibility to, 7; BCC7   (TP53)
Breast Cancer   (TP53)
Colorectal Cancer; CRC   (TP53)
Glioma Susceptibility 1; GLM1   (TP53)
Hepatocellular Carcinoma   (TP53)
Li-Fraumeni Syndrome 1; LFS1   (TP53)
Nasopharyngeal Carcinoma   (TP53)
Osteogenic Sarcoma   (TP53)
Pancreatic Cancer   (TP53)
Papilloma of Choroid Plexus   (TP53)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(Trp53A135V)L3Ber/0

        involves: C57BL/6 * CD-1
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • old mice tolerate anesthetics poorly   (MGI Ref ID J:73757)
  • premature aging
    • mice exhibit some phenotypes associated with premature ageing   (MGI Ref ID J:73757)
  • premature death
    • decrease in median and maximal lifespans compared to wild-type controls   (MGI Ref ID J:73757)
  • tumorigenesis
  • decreased tumor incidence
    • mice exhibit a 20% tumor incidence by 18 months of age with most mice remaining tumor free by 18 months of age   (MGI Ref ID J:73757)
  • lung adenocarcinoma   (MGI Ref ID J:73757)
  • homeostasis/metabolism phenotype
  • delayed wound healing
    • at 16 to 18 months of age   (MGI Ref ID J:73757)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • old mice tolerate anesthetics poorly   (MGI Ref ID J:73757)
  • skeleton phenotype
  • kyphosis
    • by 18 to 20 months of age, mice exhibit lordokyphosis   (MGI Ref ID J:73757)
  • lordosis
    • by 18 to 20 months of age, mice exhibit lordokyphosis   (MGI Ref ID J:73757)
  • osteoporosis
    • at 18 months of age   (MGI Ref ID J:73757)
  • adipose tissue phenotype
  • decreased subcutaneous adipose tissue amount
    • at 16 to 18 months of age   (MGI Ref ID J:73757)
  • behavior/neurological phenotype
  • lethargy
    • at 18 to 20 months of age   (MGI Ref ID J:73757)
  • endocrine/exocrine gland phenotype
  • decreased testis weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • growth/size phenotype
  • weight loss
    • at 18 to 20 months of age   (MGI Ref ID J:73757)
  • hematopoietic system phenotype
  • decreased spleen weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • immune system phenotype
  • decreased spleen weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • liver/biliary system phenotype
  • decreased liver weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • muscle phenotype
  • decreased skeletal muscle mass
    • at 18 months of age   (MGI Ref ID J:73757)
  • renal/urinary system phenotype
  • decreased kidney weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • reproductive system phenotype
  • decreased testis weight
    • at 18 months of age   (MGI Ref ID J:73757)
  • integument phenotype
  • alopecia
    • some in older mice   (MGI Ref ID J:73757)
  • decreased subcutaneous adipose tissue amount
    • at 16 to 18 months of age   (MGI Ref ID J:73757)
  • delayed hair regrowth
    • by 18 to 20 months of age, hair growth is observed is diminished compared to in wild-type mice   (MGI Ref ID J:73757)
  • ruffled hair
    • at 18 to 20 months of age   (MGI Ref ID J:73757)
  • sparse hair
    • at 18 to 20 months of age   (MGI Ref ID J:73757)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Adenomas
      Adenomas: lung
      Lymphomas
      Other Tissues/Organs
      Other Tissues/Organs: osteosarcoma

Internal/Organ Research
Skeleton
      Bone

Gnat2cpfl3 related

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Trp53A135V)L3Ber
Allele Name transgene insertion L3, Alan Bernstein
Allele Type Transgenic (random, expressed)
Common Name(s) Tg(Trp53A135V)2Ber; Tg(pL53)3Ber; UL53-3; p53val135; pL53-3;
Strain of OriginCD-1
Expressed Gene Trp53, transformation related protein 53, mouse, laboratory
Promoter Trp53, transformation related protein 53, mouse, laboratory
General Note Additional lines L1 and L2 were produced.

Homozygous transgenic mice are viable and fertile, but show a high incidence of tumors, particularly lung adenocarcinomas, osteosarcomas, and lymphomas.

Molecular Note The transgene contains the mouse transformation related protein 53 promoter and an allele of the mouse Trp53 gene that carries a point mutation in codon 135 (GCG to GTG), resulting in an alanine to valine substitution. The Trp53 promoter drove high levels of transgenic expression in the spleen, thymus, and lymph nodes. Transgenic expression was also reported in the ovaries. Little or no expression was reported to have been observed in the liver and lungs of these mice. [MGI Ref ID J:19870]
 
 
Allele Symbol Gnat2cpfl3
Allele Name cone photoreceptor function loss 3
Allele Type Spontaneous
Strain of Originvarious
Gene Symbol and Name Gnat2, guanine nucleotide binding protein, alpha transducing 2
Chromosome 3
Gene Common Name(s) ACHM4; AW490837; GNATC; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837;
General Note This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428)
Molecular Note A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from aspartic acid to asparagine. [MGI Ref ID J:122428]

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Trp53A135V)L3Ber, Restriction Enzyme Digest


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Harvey M; Vogel H; Morris D; Bradley A; Bernstein A; Donehower LA. 1995. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet 9(3):305-11. [PubMed: 7773294]  [MGI Ref ID J:23262]

Additional References

Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522]  [MGI Ref ID J:122428]

Lavigueur A; Maltby V; Mock D; Rossant J; Pawson T; Bernstein A. 1989. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol 9(9):3982-91. [PubMed: 2476668]  [MGI Ref ID J:19870]

Gnat2cpfl3 related

Alexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW. 2007. Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7. [PubMed: 17515894]  [MGI Ref ID J:121897]

Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. [PubMed: 21124780]  [MGI Ref ID J:167121]

Altimus CM; Guler AD; Alam NM; Arman AC; Prusky GT; Sampath AP; Hattar S. 2010. Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. Nat Neurosci 13(9):1107-12. [PubMed: 20711184]  [MGI Ref ID J:165280]

Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522]  [MGI Ref ID J:122428]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Deng WT; Sakurai K; Liu J; Dinculescu A; Li J; Pang J; Min SH; Chiodo VA; Boye SL; Chang B; Kefalov VJ; Hauswirth WW. 2009. Functional interchangeability of rod and cone transducin alpha-subunits. Proc Natl Acad Sci U S A 106(42):17681-6. [PubMed: 19815523]  [MGI Ref ID J:153749]

Naarendorp F; Esdaille TM; Banden SM; Andrews-Labenski J; Gross OP; Pugh EN Jr. 2010. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci 30(37):12495-507. [PubMed: 20844144]  [MGI Ref ID J:164666]

Nusinowitz S; Ridder WH 3rd; Ramirez J. 2007. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res 84(6):1104-14. [PubMed: 17408617]  [MGI Ref ID J:126462]

Umino Y; Solessio E; Barlow RB. 2008. Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci 28(1):189-98. [PubMed: 18171936]  [MGI Ref ID J:131050]

Wang YV; Weick M; Demb JB. 2011. Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cells. J Neurosci 31(21):7670-81. [PubMed: 21613480]  [MGI Ref ID J:191557]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Tg(Trp53A135V)L3Ber related

Lavigueur A; Maltby V; Mock D; Rossant J; Pawson T; Bernstein A. 1989. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol 9(9):3982-91. [PubMed: 2476668]  [MGI Ref ID J:19870]

Tyner SD; Venkatachalam S; Choi J; Jones S; Ghebranious N; Igelmann H; Lu X; Soron G; Cooper B; Brayton C; Hee Park S; Thompson T; Karsenty G; Bradley A; Donehower LA. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415(6867):45-53. [PubMed: 11780111]  [MGI Ref ID J:73757]

Wang Y; Zhang Z; Lubet R; You M. 2005. Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf. Oncogene 24(18):3042-9. [PubMed: 15846305]  [MGI Ref ID J:98054]

Wang Y; Zhang Z; Lubet RA; You M. 2006. A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. Oncogene 25(8):1277-80. [PubMed: 16247444]  [MGI Ref ID J:107333]

Yao R; Wang Y; D'Agostini F; Izzotti A; Lubet RA; You M; De Flora S. 2005. K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke. Exp Lung Res 31(2):271-81. [PubMed: 15824025]  [MGI Ref ID J:98657]

Zhang Z; Liu Q; Lantry LE; Wang Y; Kelloff GJ; Anderson MW; Wiseman RW; Lubet RA; You M. 2000. A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res 60(4):901-7. [PubMed: 10706103]  [MGI Ref ID J:61217]

Zhang Z; Wang Y; Yao R; Li J; Lubet RA; You M. 2006. p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. Mol Cancer Res 4(6):401-10. [PubMed: 16778087]  [MGI Ref ID J:112187]

Zhang Z; Wang Y; Yao R; Li J; Yan Y; La Regina M; Lemon WL; Grubbs CJ; Lubet RA; You M. 2004. Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. Oncogene 23(21):3841-50. [PubMed: 15021904]  [MGI Ref ID J:89926]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3000.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Important Note

This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.

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