Description

Strain Information

Former Names B6.129S7-Ifngrtm1Agt/J    (Changed: 03-JAN-05 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Background Strain C57BL/6J Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2) Generation N10F15 (20-DEC-06)   Donating Investigator IMR Colony,   The Jackson Laboratory

Description
Mice homozygous for the Ifngr1^tm1 targeted mutation are viable and fertile with no overt abnormalities. They have normal T cell responses but are defective in natural resistance, evidenced by an increased susceptibility to infection by Listeria monocytogenes and vaccinia virus.

Development
A targeting vector containing a neo cassette was used to disrupt exon 5. The construct was electroporated into 129S7/SvEvBrd-Hprt1⁺ derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric male animals were crossed to 129SvEv female mice, and then backcrossed to C57BL/6J for 10 generations.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

Strains carrying   Ifngr1^tm1Agt allele

002702	129-Ifngr1tm1Agt/J
007077	CByJ.129S7(B6)-Ifngr1tm1Agt/J

View Strains carrying   Ifngr1^tm1Agt     (2 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Ifngr1^tm1Agt/Ifngr1^tm1Agt

        involves: 129S7/SvEvBrd

• immune system phenotype
• increased susceptibility to viral infection (MGI Ref ID J:81243)
  • slightly more susceptible to MCMV viral infection than controls

Ifngr1^tm1Agt/Ifngr1^tm1Agt

        involves: 129S7/SvEvBrd * C57BL/6

• immune system phenotype
• abnormal immune cell physiology (MGI Ref ID J:99347)
  • splenocytes proliferate against the antigen and a mitogen more vigorously than those from wild-type
• increased interferon-gamma secretion (MGI Ref ID J:99347)
  • stimulation of splenocytes with an antigen or a mitogen induces a higher production of IFN-gamma than in wild-type
• increased interleukin-6 secretion (MGI Ref ID J:99347)
  • stimulation of splenocytes with an antigen induces a higher production of IL-4, IL-6, IL-13 and IFN-gamma than in wild-type
  • stimulation of splenocytes with a mitogen induces a higher production of IL-13
• increased susceptibility to experimental autoimmune uveoretinitis (MGI Ref ID J:99347)
  • exhibit increased incidence and severity of induced experimental autoimmune uveoretinitis compared to wild-type (59.3% vs. 40% of wild-type)
  • upon uveoretinitis induction, see a significant infiltration of eosinophils into the eyes compared to wild-type
• liver/biliary system phenotype
• *normal* liver/biliary system phenotype (MGI Ref ID J:120559)
  • mice show no liver injury on treatment with HBsAg-specific Th1 cells and HBsAg

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Ifngr1^tm1Agt related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information

Allele Symbol		Ifngr1tm1Agt
Allele Name		targeted mutation 1, Michel Aguet
Allele Type		Targeted (knock-out)
Common Name(s)		IFN-gamma R-; IFN-gamma R<0>; IFN-gamma-R KO; IFN-gammaR KO; IFN-gammaR-; IFN-gammaR1-; IFN-gammaR0; IFN-gammaRalpha_; IFNgR KO; IFNgammaR KO; IFn type II receptor; Ifngr-; Ifngr1-;
Mutation Made By		Michel Aguet,   Swiss Inst. for Experimental Cancer Res.
Strain of Origin		129S7/SvEvBrd-Hprt1<+>
ES Cell Line Name		AB1
ES Cell Line Strain		129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name		Ifngr1, interferon gamma receptor 1
Chromosome		10
Gene Common Name(s)		CD119; FLJ45734; IFN-gamma R; IFN-gammaR; IFNGR; Ifgr; Nktar;
Molecular Note		Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. [MGI Ref ID J:61321] [MGI Ref ID J:63815] [MGI Ref ID J:96036]

Genotyping

Genotyping Information

Genotyping Protocols

Ifngr1^tm1Agt, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Huang S; Hendriks W; Althage A; Hemmi S; Bluethmann H; Kamijo R; Vilcek J; Zinkernagel RM; Aguet M. 1993. Immune response in mice that lack the interferon-gamma receptor [see comments] Science 259(5102):1742-5. [PubMed: 8456301]  [MGI Ref ID J:63815]

Additional References

Anfossi N; Robbins SH; Ugolini S; Georgel P; Hoebe K; Bouneaud C; Ronet C; Kaser A; DiCioccio CB; Tomasello E; Blumberg RS; Beutler B; Reiner SL; Alexopoulou L; Lantz O; Raulet DH; Brossay L; Vivier E. 2004. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol 173(6):3773-82. [PubMed: 15356124]  [MGI Ref ID J:92767]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Feng CG; Collazo-Custodio CM; Eckhaus M; Hieny S; Belkaid Y; Elkins K; Jankovic D; Taylor GA; Sher A. 2004. Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol 172(2):1163-8. [PubMed: 14707092]  [MGI Ref ID J:87364]

Gadjeva M; Verschoor A; Brockman MA; Jezak H; Shen LM; Knipe DM; Carroll MC. 2002. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. J Immunol 169(10):5489-95. [PubMed: 12421924]  [MGI Ref ID J:80067]

Hancock WW; Szaba FM; Berggren KN; Parent MA; Mullarky IK; Pearl J; Cooper AM; Ely KH; Woodland DL; Kim IJ; Blackman MA; Johnson LL; Smiley ST. 2004. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A 101(9):3005-10. [PubMed: 14976252]  [MGI Ref ID J:88648]

Kamijo R; Le J; Shapiro D; Havell EA; Huang S; Aguet M; Bosland M; Vilcek J. 1993. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J Exp Med 178(4):1435-40. [PubMed: 8376946]  [MGI Ref ID J:47412]

Townsend MJ; Weinmann AS; Matsuda JL; Salomon R; Farnham PJ; Biron CA; Gapin L; Glimcher LH. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20(4):477-94. [PubMed: 15084276]  [MGI Ref ID J:89776]

Ifngr1^tm1Agt related

Abril C; Engels M; Liman A; Hilbe M; Albini S; Franchini M; Suter M; Ackermann M. 2004. Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice. J Virol 78(7):3644-53. [PubMed: 15016885]  [MGI Ref ID J:89073]

Alimi E; Huang S; Brazillet MP; Charreire J. 1998. Experimental autoimmune thyroiditis (EAT) in mice lacking the IFN-gamma receptor gene. Eur J Immunol 28(1):201-8. [PubMed: 9485200]  [MGI Ref ID J:45901]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. [PubMed: 17534845]  [MGI Ref ID J:122272]

Amani V; Vigario AM; Belnoue E; Marussig M; Fonseca L; Mazier D; Renia L. 2000. Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection Eur J Immunol 30(6):1646-55. [PubMed: 10898501]  [MGI Ref ID J:62732]

Andersson A; Dai WJ; Di Santo JP; Brombacher F. 1998. Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells. J Immunol 161(10):5600-6. [PubMed: 9820538]  [MGI Ref ID J:115035]

Anguita J; Thomas V; Samanta S; Persinski R; Hernanz C; Barthold SW; Fikrig E. 2001. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. J Immunol 167(6):3383-90. [PubMed: 11544329]  [MGI Ref ID J:118032]

Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. [PubMed: 10411532]  [MGI Ref ID J:56503]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. [PubMed: 16177303]  [MGI Ref ID J:104232]

Barton ES; Lutzke ML; Rochford R; Virgin HW th. 2005. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol 79(22):14149-60. [PubMed: 16254350]  [MGI Ref ID J:102489]

Batten M; Li J; Yi S; Kljavin NM; Danilenko DM; Lucas S; Lee J; de Sauvage FJ; Ghilardi N. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7(9):929-36. [PubMed: 16906167]  [MGI Ref ID J:112662]

Becskei A; Grusby MJ. 2007. Contribution of IL-12R mediated feedback loop to Th1 cell differentiation. FEBS Lett 581(27):5199-206. [PubMed: 17950290]  [MGI Ref ID J:127745]

Berner V; Liu H; Zhou Q; Alderson KL; Sun K; Weiss JM; Back TC; Longo DL; Blazar BR; Wiltrout RH; Welniak LA; Redelman D; Murphy WJ. 2007. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 13(3):354-60. [PubMed: 17334371]  [MGI Ref ID J:121706]

Biondo C; Midiri A; Gambuzza M; Gerace E; Falduto M; Galbo R; Bellantoni A; Beninati C; Teti G; Leanderson T; Mancuso G. 2008. IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis. J Immunol 181(1):566-73. [PubMed: 18566423]  [MGI Ref ID J:137360]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Blasius AL; Giurisato E; Cella M; Schreiber RD; Shaw AS; Colonna M. 2006. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 177(5):3260-5. [PubMed: 16920966]  [MGI Ref ID J:139501]

Bohatschek M; Kloss CU; Hristova M; Pfeffer K; Raivich G. 2004. Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2. J Comp Neurol 470(4):382-99. [PubMed: 14961564]  [MGI Ref ID J:109424]

Boyman O; Hefti HP; Conrad C; Nickoloff BJ; Suter M; Nestle FO. 2004. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med 199(5):731-6. [PubMed: 14981113]  [MGI Ref ID J:90470]

Brillard E; Pallandre JR; Chalmers D; Ryffel B; Radlovic A; Seilles E; Rohrlich PS; Pivot X; Tiberghien P; Saas P; Borg C. 2007. Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. Exp Hematol 35(3):416-25. [PubMed: 17309822]  [MGI Ref ID J:123184]

Brisebois M; Zehntner SP; Estrada J; Owens T; Fournier S. 2006. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J Immunol 177(4):2403-11. [PubMed: 16888002]  [MGI Ref ID J:138386]

Brown N; Jacobs M; Parida SK; Botha T; Santos A; Fick L; Gicquel B; Jackson M; Quesniaux V; Ryffel B. 2005. Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection. Infect Immun 73(1):666-70. [PubMed: 15618214]  [MGI Ref ID J:94835]

Car BD; Eng VM; Schnyder B; Ozmen L; Huang S; Gallay P; Heumann D; Aguet M; Ryffel B. 1994. Interferon gamma receptor deficient mice are resistant to endotoxic shock. J Exp Med 179(5):1437-44. [PubMed: 8163930]  [MGI Ref ID J:17878]

Caturegli P; Hejazi M; Suzuki K; Dohan O; Carrasco N; Kohn LD; Rose NR. 2000. Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid. Proc Natl Acad Sci U S A 97(4):1719-24. [PubMed: 10677524]  [MGI Ref ID J:126141]

Cenci E; Mencacci A; Del Sero G; d'Ostiani CF; Mosci P; Bacci A; Montagnoli C; Kopf M; Romani L. 1998. IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection. J Immunol 161(7):3543-50. [PubMed: 9759875]  [MGI Ref ID J:115201]

Chen GH; McDonald RA; Wells JC; Huffnagle GB; Lukacs NW; Toews GB. 2005. The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans. Infect Immun 73(3):1788-96. [PubMed: 15731080]  [MGI Ref ID J:96679]

Ching S; He L; Lai W; Quan N. 2005. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun 19(2):127-37. [PubMed: 15664785]  [MGI Ref ID J:105351]

Cohn L; Herrick C; Niu N; Homer R; Bottomly K. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166(4):2760-7. [PubMed: 11160342]  [MGI Ref ID J:126916]

Cone RE; Li X; Sharafieh R; O'Rourke J; Vella AT. 2007. The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120(1):112-9. [PubMed: 17052246]  [MGI Ref ID J:122316]

Conrad C; Boyman O; Tonel G; Tun-Kyi A; Laggner U; de Fougerolles A; Kotelianski V; Gardner H; Nestle FO. 2007. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13(7):836-42. [PubMed: 17603494]  [MGI Ref ID J:125083]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Coyle AJ; Tsuyuki S; Bertrand C; Huang S; Aguet M; Alkan SS; Anderson GP. 1996. Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 156(8):2680-5. [PubMed: 8609383]  [MGI Ref ID J:110684]

Dai WJ; Bartens W; Kohler G; Hufnagel M; Kopf M; Brombacher F. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. J Immunol 158(11):5297-304. [PubMed: 9164949]  [MGI Ref ID J:40632]

Day SL; Ramshaw IA; Ramsay AJ; Ranasinghe C. 2008. Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy. J Immunol 180(11):7158-66. [PubMed: 18490714]  [MGI Ref ID J:136349]

Deckert-Schluter M; Bluethmann H; Kaefer N; Rang A; Schluter D. 1999. Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis. Am J Pathol 154(5):1549-61. [PubMed: 10329607]  [MGI Ref ID J:114203]

Delisle JS; Gaboury L; Belanger MP; Tasse E; Yagita H; Perreault C. 2008. Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hosts. Blood 112(5):2111-9. [PubMed: 18552211]  [MGI Ref ID J:138728]

Drennan MB; Stijlemans B; Van den Abbeele J; Quesniaux VJ; Barkhuizen M; Brombacher F; De Baetselier P; Ryffel B; Magez S. 2005. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol 175(4):2501-9. [PubMed: 16081822]  [MGI Ref ID J:107495]

Dunn GP; Bruce AT; Sheehan KC; Shankaran V; Uppaluri R; Bui JD; Diamond MS; Koebel CM; Arthur C; White JM; Schreiber RD. 2005. A critical function for type I interferons in cancer immunoediting. Nat Immunol 6(7):722-9. [PubMed: 15951814]  [MGI Ref ID J:99146]

Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. [PubMed: 10754318]  [MGI Ref ID J:123432]

Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. [PubMed: 11884466]  [MGI Ref ID J:126678]

Ebrahimi B; Dutia BM; Brownstein DG; Nash AA. 2001. Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout mice. Am J Pathol 158(6):2117-25. [PubMed: 11395389]  [MGI Ref ID J:114409]

Echtenacher B; Freudenberg MA; Jack RS; Mannel DN. 2001. Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun 69(12):7271-6. [PubMed: 11705897]  [MGI Ref ID J:73132]

El Fakhry Y; Achbarou A; Desportes I; Mazier D. 2001. Resistance to Encephalitozoon intestinalis is associated with interferon-gamma and interleukin-2 cytokines in infected mice. Parasite Immunol 23(6):297-303. [PubMed: 11412382]  [MGI Ref ID J:103905]

Eng VM; Car BD; Schnyder B; Lorenz M; Lugli S; Aguet M; Anderson TD; Ryffel B; Quesniaux VF. 1995. The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo. J Exp Med 181(5):1893-8. [PubMed: 7722464]  [MGI Ref ID J:24954]

Eriksson U; Kurrer MO; Bingisser R; Eugster HP; Saremaslani P; Follath F; Marsch S; Widmer U. 2001. Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction. Circulation 103(1):18-21. [PubMed: 11136679]  [MGI Ref ID J:133483]

Espejo C; Penkowa M; Saez-Torres I; Hidalgo J; Garcia A; Montalban X; Martinez-Caceres EM. 2002. Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis. Exp Neurol 177(1):21-31. [PubMed: 12429207]  [MGI Ref ID J:79181]

Evans AG; Moser JM; Krug LT; Pozharskaya V; Mora AL; Speck SH. 2008. A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. J Exp Med 205(3):669-84. [PubMed: 18332178]  [MGI Ref ID J:133376]

Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. [PubMed: 17372191]  [MGI Ref ID J:120115]

Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. [PubMed: 16493042]  [MGI Ref ID J:129422]

Fiette L; Aubert C; Muller U; Huang S; Aguet M; Brahic M; Bureau JF. 1995. Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. J Exp Med 181(6):2069-76. [PubMed: 7759999]  [MGI Ref ID J:25679]

Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387]  [MGI Ref ID J:99143]

Foulds KE; Rotte MJ; Paley MA; Singh B; Douek DC; Hill BJ; O'Shea JJ; Watford WT; Seder RA; Wu CY. 2008. IFN-gamma mediates the death of Th1 cells in a paracrine manner. J Immunol 180(2):842-9. [PubMed: 18178823]  [MGI Ref ID J:130963]

Fukushima A; Yamaguchi T; Ishida W; Fukata K; Udaka K; Ueno H. 2005. Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses. Immunogenetics 57(5):337-43. [PubMed: 15902435]  [MGI Ref ID J:99347]

Gangadharan B; Hoeve MA; Allen JE; Ebrahimi B; Rhind SM; Dutia BM; Nash AA. 2008. Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages. J Leukoc Biol 84(1):50-8. [PubMed: 18436582]  [MGI Ref ID J:137747]

Gao Y; Grassi F; Ryan MR; Terauchi M; Page K; Yang X; Weitzmann MN; Pacifici R. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32. [PubMed: 17173138]  [MGI Ref ID J:117462]

Geserick P; Kaiser F; Klemm U; Kaufmann SH; Zerrahn J. 2004. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol 16(10):1535-48. [PubMed: 15351786]  [MGI Ref ID J:93660]

Gil MP; Bohn E; O'Guin AK; Ramana CV; Levine B; Stark GR; Virgin HW; Schreiber RD. 2001. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 98(12):6680-5. [PubMed: 11390995]  [MGI Ref ID J:81243]

Glickstein L; Edelstein M; Dong JZ. 2001. Gamma interferon is not required for arthritis resistance in the murine lyme disease model. Infect Immun 69(6):3737-43. [PubMed: 11349038]  [MGI Ref ID J:69540]

Goes N; Urmson J; Hobart M; Halloran PF. 1996. The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium. Transplantation 62(12):1889-94. [PubMed: 8990382]  [MGI Ref ID J:37405]

Grob P; Schijns VE; van den Broek MF; Cox SP; Ackermann M; Suter M. 1999. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol 73(6):4748-54. [PubMed: 10233935]  [MGI Ref ID J:110066]

Gupta S; Pablo AM; Jiang Xc; Wang N; Tall AR; Schindler C. 1997. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest 99(11):2752-61. [PubMed: 9169506]  [MGI Ref ID J:40921]

Guy-Grand D; DiSanto JP; Henchoz P; Malassis-Seris M; Vassalli P. 1998. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol 28(2):730-44. [PubMed: 9521083]  [MGI Ref ID J:114275]

Gysemans CA; Pavlovic D; Bouillon R; Eizirik DL; Mathieu C. 2001. Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction. Diabetologia 44(5):567-74. [PubMed: 11380074]  [MGI Ref ID J:107148]

Haas C; Ryffel B; Le Hir M. 1997. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J Immunol 158(11):5484-91. [PubMed: 9164971]  [MGI Ref ID J:40633]

Haas C; Ryffel B; Le Hir M. 1998. IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol 160(8):3713-8. [PubMed: 9558072]  [MGI Ref ID J:111168]

Haas C; Ryffel B; LeHir M. 1995. Crescentic glomerulonephritis in interferon-gamma receptor deficient mice. J Inflamm 47(4):206-213. [PubMed: 9144077]  [MGI Ref ID J:40531]

Hancock WW; Szaba FM; Berggren KN; Parent MA; Mullarky IK; Pearl J; Cooper AM; Ely KH; Woodland DL; Kim IJ; Blackman MA; Johnson LL; Smiley ST. 2004. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A 101(9):3005-10. [PubMed: 14976252]  [MGI Ref ID J:88648]

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Schijns VE; Haagmans BL; Horzinek MC. 1995. IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice. J Immunol 155(5):2525-32. [PubMed: 7650382]  [MGI Ref ID J:28197]

Schijns VE; Haagmans BL; Rijke EO; Huang S; Aguet M; Horzinek MC. 1994. IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J Immunol 153(5):2029-37. [PubMed: 8051408]  [MGI Ref ID J:19758]

Schijns VE; Haagmans BL; Wierda CM; Kruithof B; Heijnen IA; Alber G; Horzinek MC. 1998. Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160(8):3958-64. [PubMed: 9558103]  [MGI Ref ID J:46942]

Schijns VE; Wierda CM; van Hoeij M; Horzinek MC. 1996. Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12. J Immunol 157(2):815-21. [PubMed: 8752933]  [MGI Ref ID J:34040]

Schwarting A; Moore K; Wada T; Tesch G; Yoon HJ; Kelley VR. 1998. IFN-gamma limits macrophage expansion in MRL-Fas(lpr) autoimmune interstitial nephritis: a negative regulatory pathway. J Immunol 160(8):4074-81. [PubMed: 9558118]  [MGI Ref ID J:111003]

Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. [PubMed: 16393956]  [MGI Ref ID J:126599]

Sewnath ME; Van Der Poll T; Van Noorden CJ; Ten Kate FJ; Gouma DJ. 2002. Endogenous interferon gamma protects against cholestatic liver injury in mice. Hepatology 36(6):1466-77. [PubMed: 12447873]  [MGI Ref ID J:106209]

Shankaran V; Ikeda H; Bruce AT; White JM; Swanson PE; Old LJ; Schreiber RD. 2001. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410(6832):1107-11. [PubMed: 11323675]  [MGI Ref ID J:80176]

Shaw MH; Freeman GJ; Scott MF; Fox BA; Bzik DJ; Belkaid Y; Yap GS. 2006. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol 176(12):7263-71. [PubMed: 16751369]  [MGI Ref ID J:132232]

Shen H; Iwasaki A. 2006. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 116(8):2237-43. [PubMed: 16878177]  [MGI Ref ID J:113124]

Shresta S; Kyle JL; Snider HM; Basavapatna M; Beatty PR; Harris E. 2004. Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. J Virol 78(6):2701-10. [PubMed: 14990690]  [MGI Ref ID J:88819]

Shresta S; Sharar KL; Prigozhin DM; Snider HM; Beatty PR; Harris E. 2005. Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. J Immunol 175(6):3946-54. [PubMed: 16148142]  [MGI Ref ID J:116690]

Skoberne M; Geginat G. 2002. Efficient in vivo presentation of Listeria monocytogenes- derived CD4 and CD8 T cell epitopes in the absence of IFN-gamma. J Immunol 168(4):1854-60. [PubMed: 11823519]  [MGI Ref ID J:74477]

Spiller S; Elson G; Ferstl R; Dreher S; Mueller T; Freudenberg M; Daubeuf B; Wagner H; Kirschning CJ. 2008. TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J Exp Med 205(8):1747-54. [PubMed: 18644971]  [MGI Ref ID J:138218]

Sporri R; Joller N; Albers U; Hilbi H; Oxenius A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol 176(10):6162-71. [PubMed: 16670325]  [MGI Ref ID J:131762]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Sun R; Gao B. 2004. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology 127(5):1525-39. [PubMed: 15521020]  [MGI Ref ID J:107757]

Swihart K; Fruth U; Messmer N; Hug K; Behin R; Huang S; Del Giudice G; Aguet M; Louis JA. 1995. Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J Exp Med 181(3):961-71. [PubMed: 7869054]  [MGI Ref ID J:23339]

Szabo SJ; Kim ST; Costa GL; Zhang X; Fathman CG; Glimcher LH. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100(6):655-69. [PubMed: 10761931]  [MGI Ref ID J:61321]

Szalay G; Ladel CH; Blum C; Kaufmann SH. 1996. IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice. J Immunol 157(11):4746-50. [PubMed: 8943375]  [MGI Ref ID J:37042]

Tay CH; Welsh RM. 1997. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J Virol 71(1):267-75. [PubMed: 8985346]  [MGI Ref ID J:37971]

Templeton SP; Perlman S. 2008. Role of IFN-gamma responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice. J Neuroimmunol 194(1-2):18-26. [PubMed: 18082272]  [MGI Ref ID J:131907]

Tran EH; Prince EN; Owens T. 2000. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164(5):2759-68. [PubMed: 10679118]  [MGI Ref ID J:60605]

Tsuji M; Miyahira Y; Nussenzweig RS; Aguet M; Reichel M; Zavala F. 1995. Development of antimalaria immunity in mice lacking IFN-gamma receptor. J Immunol 154(10):5338-44. [PubMed: 7537305]  [MGI Ref ID J:25111]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760]  [MGI Ref ID J:129273]

Valaperti A; Marty RR; Kania G; Germano D; Mauermann N; Dirnhofer S; Leimenstoll B; Blyszczuk P; Dong C; Mueller C; Hunziker L; Eriksson U. 2008. CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J Immunol 180(4):2686-95. [PubMed: 18250481]  [MGI Ref ID J:131968]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

Van den Steen PE; Deroost K; Aelst IV; Geurts N; Martens E; Struyf S; Nie CQ; Hansen DS; Matthys P; Damme JV; Opdenakker G. 2008. CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines. Eur J Immunol 38(4):1082-95. [PubMed: 18383042]  [MGI Ref ID J:133766]

Vermeire K; Heremans H; Vandeputte M; Huang S; Billiau A; Matthys P. 1997. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol 158(11):5507-13. [PubMed: 9164974]  [MGI Ref ID J:40635]

Viero C; Mechaly I; Aptel H; Puech S; Valmier J; Bancel F; Dayanithi G. 2006. Rapid inhibition of Ca(2+) influx by neurosteroids in murine embryonic sensory neurones Cell Calcium 40(4):383-91. [PubMed: 16769113]  [MGI Ref ID J:110866]

Vila-del Sol V; Diaz-Munoz MD; Fresno M. 2007. Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. J Leukoc Biol 81(1):272-83. [PubMed: 17035338]  [MGI Ref ID J:117247]

Vollstedt S; Arnold S; Schwerdel C; Franchini M; Alber G; Di Santo JP; Ackermann M; Suter M. 2004. Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1. J Virol 78(8):3846-50. [PubMed: 15047800]  [MGI Ref ID J:89128]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating System	Homozygote x Homozygote         (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Tel: 800.422.6423 or 207.288.5845
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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.