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- Description
- Disease & phenotype
- Genes & alleles
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Description
Strain Information
Former Names C57BL/6-Tg(ACTB-EGFP)1Osb/J (Changed: 08-MAY-08 ) C57BL/6-Tg(ACTbEGFP)1Osb/J (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder. Species laboratory mouse Generation N?+34 (17-SEP-12)
Generation DefinitionsDonating Investigator Dr. Masaru Okabe, Osaka University Appearance
black
Related Genotype: a/aDescription
This transgenic mouse line with an "enhanced" GFP (EGFP) cDNA under the control of a chicken beta-actin promoter and cytomegalovirus enhancer makes all of the tissues, with the exception of erythrocytes and hair, appear green under excitation light. Note that the donating investigator reports that mice homozygous for this transgene die within the first two weeks following birth.Of note, it has been the experience at The Jackson Laboratory that Stock No. 006567 (C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ) demonstrates the highest proportion of GFP expressing cell populations in bone marrow, thymus, spleen and peripheral blood when compared to Stock No. 003291 (C57BL/6-Tg(CAG-EGFP)1Osb/J) and Stock No. 007075 (CByJ.B6-Tg(CAG-EGFP)1Osb/J).
View the pdf document on GFP Expressing Lymphocyte Populations in C57BL/6-Tg(CAG-EGFP)1Osb/J, C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ and CByJ.B6-Tg(CAG-EGFP)1Osb/J.
Development
The EcoRI sites included in the PCR primers were used to introduce the amplified EGFP cDNA into a pCAGGS expression vector containing the chicken beta-actin promoter and cytomegalovirus enhancer, beta-actin intron and bovine globin poly-adenylation signal. The entire insert with the promoter and coding sequence was excised with Bam-HI and SalI and gel-purified. This strain was generated in C57BL/6 mice.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (357 strains)
007075 CByJ.B6-Tg(CAG-EGFP)1Osb/J 017619 NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
Additional Web Information
Fluorescent Proteins/lacZ Systems
JAX® NOTES, Fall 2002; 487. Green Fluorescent Protein (GFP) Transgenic Mice Poster Available.
JAX® NOTES, Summer 2002; 486. Visualizing JAX® Mice Strains Carrying Fluorescent Proteins.
Phenotype
Phenotype Information
assigned by genotype
Tg(CAG-EGFP)1Osb/0
C57BL/6-Tg(CAG-EGFP)1Osb/J
- normal phenotype
- no abnormal phenotype detected
Tg(CAG-EGFP)1Osb/Tg(CAG-EGFP)1Osb
C57BL/6-Tg(CAG-EGFP)1Osb/J
- mortality/aging
- complete prenatal lethality
- homozygous transgenic mice die in the embryonic stage, putatively due to integration site effect (MGI Ref ID J:87298)
This mouse can be used to support research in many areas including:
GFP relatedResearch Tools
Cardiovascular Research
Fluorescent Proteins
Genetics Research
Tissue/Cell Markers
Reproductive Biology Research
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(CAG-EGFP)1Osb | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Research Institute for Microbial Diseases, Osaka University | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | (ACTbEGFP)10sb; GFP; Ten(ACTbEGFP)1Osb; Tg(ACTB-EGFP)1Osb; Tg(ACTbEGFP)1Osb; Tg(CAG-EGFP)1Osb; TgN(ACTbEGFP)1Osb; TgN(beta-act-EFGP)01Osb; beta-actin-GFP; pCAGGS-GFP; | ||
| Mutation Made By | Dr. Masaru Okabe, Osaka University | ||
| Strain of Origin | B6C3F2 | ||
| Site of Expression | All tissues, with the exception of erythrocytes and hair, appear green under excitation light. | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | ACTB, actin, beta, chicken | ||
| Gene Symbol and Name | Tg(CAG-EGFP)1Osb, transgene insertion 1, Research Institute for Microbial Diseases, Osaka University | ||
| Chromosome | UN | ||
| Gene Common Name(s) | (ACTbEGFP)10sb; GFP; Tg(ACTB-EGFP)1Osb; Tg(ACTbEGFP)1Osb; TgN(ACTbEGFP)1Osb; TgN(beta-act-EFGP)01Osb; | ||
| Molecular Note | cDNA encoding enhanced green fluorescent protein (EGFP) was adjoined to the chicken beta actin promoter and cytomegalovirus enhancer. A bovine globin polyadenylation signal was also included in the construct. [MGI Ref ID J:87415] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fluorescent Proteins (Generic GFP), Melt Curve Analysis
Fluorescent Proteins (Generic GFP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Okabe M; Ikawa M; Kominami K; Nakanishi T; Nishimune Y. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407(3):313-9. [PubMed: 9175875] [MGI Ref ID J:87415]
Additional References
Klebanoff CA; Finkelstein SE; Surman DR; Lichtman MK; Gattinoni L; Theoret MR; Grewal N; Spiess PJ; Antony PA; Palmer DC; Tagaya Y; Rosenberg SA; Waldmann TA; Restifo NP. 2004. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci U S A 101(7):1969-74. [PubMed: 14762166] [MGI Ref ID J:90388]
Liu Z; Martin LJ. 2003. Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. J Comp Neurol 459(4):368-91. [PubMed: 12687705] [MGI Ref ID J:83153]
Maxwell JR; Rossi RJ; McSorley SJ; Vella AT. 2004. T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation. J Immunol 172(1):248-59. [PubMed: 14688332] [MGI Ref ID J:87095]
Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354] [MGI Ref ID J:91367]
Wu YP; Proia RL. 2004. Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc Natl Acad Sci U S A 101(22):8425-30. [PubMed: 15155903] [MGI Ref ID J:90687]
Yagi T; McMahon EJ; Takikita S; Mohri I; Matsushima GK; Suzuki K. 2004. Fate of donor hematopoietic cells in demyelinating mutant mouse, twitcher, following transplantation of GFP+ bone marrow cells. Neurobiol Dis 16(1):98-109. [PubMed: 15207267] [MGI Ref ID J:91240]
Tg(CAG-EGFP)1Osb relatedAghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747] [MGI Ref ID J:112935]
Amano K; Okigaki M; Adachi Y; Fujiyama S; Mori Y; Kosaki A; Iwasaka T; Matsubara H. 2004. Mechanism for IL-1 beta-mediated neovascularization unmasked by IL-1 beta knock-out mice. J Mol Cell Cardiol 36(4):469-80. [PubMed: 15081307] [MGI Ref ID J:101965]
Amin AH; Abd Elmageed ZY; Nair D; Partyka MI; Kadowitz PJ; Belmadani S; Matrougui K. 2010. Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice. Lab Invest 90(7):985-96. [PubMed: 20440273] [MGI Ref ID J:162143]
Ando S; Abe R; Sasaki M; Murata J; Inokuma D; Shimizu H. 2009. Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer. Am J Pathol 174(2):595-601. [PubMed: 19131588] [MGI Ref ID J:144196]
Anghelina M; Krishnan P; Moldovan L; Moldovan NI. 2006. Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am J Pathol 168(2):529-41. [PubMed: 16436667] [MGI Ref ID J:106289]
Auda-Boucher G; Rouaud T; Lafoux A; Levitsky D; Huchet-Cadiou C; Feron M; Guevel L; Talon S; Fontaine-Perus J; Gardahaut MF. 2007. Fetal muscle-derived cells can repair dystrophic muscles in mdx mice. Exp Cell Res 313(5):997-1007. [PubMed: 17275812] [MGI Ref ID J:119767]
Azuma K; Ichimura K; Mita T; Nakayama S; Jin WL; Hirose T; Fujitani Y; Sumiyoshi K; Shimada K; Daida H; Sakai T; Mitsumata M; Kawamori R; Watada H. 2009. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta. Biochem Biophys Res Commun 380(3):620-6. [PubMed: 19285011] [MGI Ref ID J:147062]
Badders NM; Goel S; Clark RJ; Klos KS; Kim S; Bafico A; Lindvall C; Williams BO; Alexander CM. 2009. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One 4(8):e6594. [PubMed: 19672307] [MGI Ref ID J:152469]
Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Am J Pathol 178(1):161-74. [PubMed: 21224054] [MGI Ref ID J:168235]
Barroca V; Mouthon MA; Lewandowski D; Brunet de la Grange P; Gauthier LR; Pflumio F; Boussin FD; Arwert F; Riou L; Allemand I; Romeo PH; Fouchet P. 2012. Impaired functionality and homing of Fancg-deficient hematopoietic stem cells. Hum Mol Genet 21(1):121-35. [PubMed: 21968513] [MGI Ref ID J:178857]
Beleut M; Rajaram RD; Caikovski M; Ayyanan A; Germano D; Choi Y; Schneider P; Brisken C. 2010. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A 107(7):2989-94. [PubMed: 20133621] [MGI Ref ID J:157571]
Bentzon JF; Sondergaard CS; Kassem M; Falk E. 2007. Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice. Circulation 116(18):2053-61. [PubMed: 17938286] [MGI Ref ID J:142997]
Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426] [MGI Ref ID J:132002]
Bi Y; Ehirchiou D; Kilts TM; Inkson CA; Embree MC; Sonoyama W; Li L; Leet AI; Seo BM; Zhang L; Shi S; Young MF. 2007. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13(10):1219-27. [PubMed: 17828274] [MGI Ref ID J:129922]
Bradshaw G; Gutierrez A; Miyake JH; Davis KR; Li AC; Glass CK; Curtiss LK; Davis RA. 2005. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Proc Natl Acad Sci U S A 102(31):11029-34. [PubMed: 16043712] [MGI Ref ID J:118732]
Bratincsak A; Brownstein MJ; Cassiani-Ingoni R; Pastorino S; Szalayova I; Toth ZE; Key S; Nemeth K; Pickel J; Mezey E. 2007. CD45-positive blood cells give rise to uterine epithelial cells in mice. Stem Cells 25(11):2820-6. [PubMed: 17656643] [MGI Ref ID J:148664]
Bruscia EM; Price JE; Cheng EC; Weiner S; Caputo C; Ferreira EC; Egan ME; Krause DS. 2006. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proc Natl Acad Sci U S A 103(8):2965-70. [PubMed: 16481627] [MGI Ref ID J:107307]
Cao C; Lawrence DA; Strickland DK; Zhang L. 2005. A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood 106(9):3234-41. [PubMed: 16002427] [MGI Ref ID J:123904]
Carlson EC; Lin M; Liu CY; Kao WW; Perez VL; Pearlman E. 2007. Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem 282(49):35502-9. [PubMed: 17911102] [MGI Ref ID J:128992]
Carreres MI; Escalante A; Murillo B; Chauvin G; Gaspar P; Vegar C; Herrera E. 2011. Transcription factor foxd1 is required for the specification of the temporal retina in mammals. J Neurosci 31(15):5673-81. [PubMed: 21490208] [MGI Ref ID J:170971]
Cheng C; Xia CH; Li L; White TW; Niimi J; Gong X. 2008. Gap junction communication influences intercellular protein distribution in the lens. Exp Eye Res 86(6):966-74. [PubMed: 18462719] [MGI Ref ID J:136989]
Chinnery HR; Carlson EC; Sun Y; Lin M; Burnett SH; Perez VL; McMenamin PG; Pearlman E. 2009. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. J Immunol 182(5):2738-44. [PubMed: 19234168] [MGI Ref ID J:146258]
Chinnery HR; Humphries T; Clare A; Dixon AE; Howes K; Moran CB; Scott D; Zakrzewski M; Pearlman E; McMenamin PG. 2008. Turnover of bone marrow-derived cells in the irradiated mouse cornea. Immunology 125(4):541-8. [PubMed: 18540963] [MGI Ref ID J:144440]
Chung SS; Wang X; Wolgemuth DJ. 2009. Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis. Development 136(12):2091-100. [PubMed: 19465599] [MGI Ref ID J:149525]
Ciarloni L; Mallepell S; Brisken C. 2007. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A 104(13):5455-60. [PubMed: 17369357] [MGI Ref ID J:120116]
Corti S; Nizzardo M; Nardini M; Donadoni C; Salani S; Simone C; Falcone M; Riboldi G; Govoni A; Bresolin N; Comi GP. 2010. Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Hum Mol Genet 19(19):3782-96. [PubMed: 20650960] [MGI Ref ID J:163630]
Dietze KK; Zelinskyy G; Gibbert K; Schimmer S; Francois S; Myers L; Sparwasser T; Hasenkrug KJ; Dittmer U. 2011. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A 108(6):2420-5. [PubMed: 21262821] [MGI Ref ID J:169103]
Dykstra B; Olthof S; Schreuder J; Ritsema M; de Haan G. 2011. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 208(13):2691-703. [PubMed: 22110168] [MGI Ref ID J:179054]
Fang J; Zhang WC; Yamashita T; Gao J; Zhu MS; Zuo J. 2012. Outer hair cell-specific prestin-CreERT2 knockin mouse lines. Genesis 50(2):124-31. [PubMed: 21954035] [MGI Ref ID J:182720]
Fang S; Wei J; Pentinmikko N; Leinonen H; Salven P. 2012. Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. PLoS Biol 10(10):e1001407. [PubMed: 23091420] [MGI Ref ID J:194015]
Fazel S; Cimini M; Chen L; Li S; Angoulvant D; Fedak P; Verma S; Weisel RD; Keating A; Li RK. 2006. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116(7):1865-77. [PubMed: 16823487] [MGI Ref ID J:111717]
Finnberg NK; Hart LS; Dolloff NG; Rodgers ZB; Dicker DT; El-Deiry WS. 2011. High-Resolution Imaging and Antitumor Effects of GFP(+) Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors. Am J Pathol 179(5):2169-76. [PubMed: 21975022] [MGI Ref ID J:177442]
Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. [PubMed: 23467088] [MGI Ref ID J:194916]
Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387] [MGI Ref ID J:99143]
Follenzi A; Raut S; Merlin S; Sarkar R; Gupta S. 2012. Role of bone marrow transplantation for correcting hemophilia A in mice. Blood 119(23):5532-42. [PubMed: 22368271] [MGI Ref ID J:186576]
Fritzell JA Jr; Mao Q; Gundavarapu S; Pasquariello T; Aliotta JM; Ayala A; Padbury JF; De Paepe ME. 2009. Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice. Am J Respir Cell Mol Biol 40(5):575-87. [PubMed: 18988921] [MGI Ref ID J:160864]
Gilchrist DS; Ure J; Hook L; Medvinsky A. 2003. Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice. Genesis 36(3):168-76. [PubMed: 12872249] [MGI Ref ID J:135901]
Gillette-Ferguson I; Daehnel K; Hise AG; Sun Y; Carlson E; Diaconu E; McGarry HF; Taylor MJ; Pearlman E. 2007. Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Infect Immun 75(12):5908-15. [PubMed: 17875630] [MGI Ref ID J:127654]
Gocheva V; Wang HW; Gadea BB; Shree T; Hunter KE; Garfall AL; Berman T; Joyce JA. 2010. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24(3):241-55. [PubMed: 20080943] [MGI Ref ID J:156936]
Grathwohl SA; Kalin RE; Bolmont T; Prokop S; Winkelmann G; Kaeser SA; Odenthal J; Radde R; Eldh T; Gandy S; Aguzzi A; Staufenbiel M; Mathews PM; Wolburg H; Heppner FL; Jucker M. 2009. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 12(11):1361-3. [PubMed: 19838177] [MGI Ref ID J:154603]
Gross DA; Chappert P; Leboeuf M; Monteilhet V; Van Wittenberghe L; Danos O; Davoust J. 2006. Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products. Blood 108(6):1841-8. [PubMed: 16741251] [MGI Ref ID J:138060]
Guo JK; Ardito TA; Kashgarian M; Krause DS. 2006. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney Int 70(5):910-3. [PubMed: 16850025] [MGI Ref ID J:136487]
Guo JK; Cheng EC; Wang L; Swenson ES; Ardito TA; Kashgarian M; Cantley LG; Krause DS. 2007. The commonly used beta-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis. Transgenic Res 16(6):829-34. [PubMed: 17594530] [MGI Ref ID J:129056]
Guo K; Mogen J; Struzzi S; Zhang Y. 2009. Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol 296(5):R1339-47. [PubMed: 19193947] [MGI Ref ID J:148045]
Hagensen MK; Shim J; Falk E; Bentzon JF. 2011. Flanking recipient vasculature, not circulating progenitor cells, contributes to endothelium and smooth muscle in murine allograft vasculopathy. Arterioscler Thromb Vasc Biol 31(4):808-13. [PubMed: 21233450] [MGI Ref ID J:184171]
Hagensen MK; Shim J; Thim T; Falk E; Bentzon JF. 2010. Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation 121(7):898-905. [PubMed: 20142446] [MGI Ref ID J:170440]
Haridass D; Yuan Q; Becker PD; Cantz T; Iken M; Rothe M; Narain N; Bock M; Norder M; Legrand N; Wedemeyer H; Weijer K; Spits H; Manns MP; Cai J; Deng H; Di Santo JP; Guzman CA; Ott M. 2009. Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol 175(4):1483-92. [PubMed: 19717639] [MGI Ref ID J:153069]
Hauser AE; Junt T; Mempel TR; Sneddon MW; Kleinstein SH; Henrickson SE; von Andrian UH; Shlomchik MJ; Haberman AM. 2007. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26(5):655-67. [PubMed: 17509908] [MGI Ref ID J:123545]
Heikenwalder M; Kurrer MO; Margalith I; Kranich J; Zeller N; Haybaeck J; Polymenidou M; Matter M; Bremer J; Jackson WS; Lindquist S; Sigurdson CJ; Aguzzi A. 2008. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity 29(6):998-1008. [PubMed: 19100703] [MGI Ref ID J:142638]
Highfill SL; Rodriguez PC; Zhou Q; Goetz CA; Koehn BH; Veenstra R; Taylor PA; Panoskaltsis-Mortari A; Serody JS; Munn DH; Tolar J; Ochoa AC; Blazar BR. 2010. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 116(25):5738-47. [PubMed: 20807889] [MGI Ref ID J:167423]
Hooper AT; Butler JM; Nolan DJ; Kranz A; Iida K; Kobayashi M; Kopp HG; Shido K; Petit I; Yanger K; James D; Witte L; Zhu Z; Wu Y; Pytowski B; Rosenwaks Z; Mittal V; Sato TN; Rafii S. 2009. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 4(3):263-74. [PubMed: 19265665] [MGI Ref ID J:149917]
Ikawa T; Hirose S; Masuda K; Kakugawa K; Satoh R; Shibano-Satoh A; Kominami R; Katsura Y; Kawamoto H. 2010. An essential developmental checkpoint for production of the T cell lineage. Science 329(5987):93-6. [PubMed: 20595615] [MGI Ref ID J:161354]
Ioannidou K; Anderson KI; Strachan D; Edgar JM; Barnett SC. 2012. Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS One 7(1):e30775. [PubMed: 22303455] [MGI Ref ID J:184214]
Ito A; Suganami T; Yamauchi A; Degawa-Yamauchi M; Tanaka M; Kouyama R; Kobayashi Y; Nitta N; Yasuda K; Hirata Y; Kuziel WA; Takeya M; Kanegasaki S; Kamei Y; Ogawa Y. 2008. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 283(51):35715-23. [PubMed: 18977759] [MGI Ref ID J:143770]
Itoi M; Tsukamoto N; Yoshida H; Amagai T. 2007. Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol 19(8):953-64. [PubMed: 17625108] [MGI Ref ID J:124645]
Iwata H; Manabe I; Fujiu K; Yamamoto T; Takeda N; Eguchi K; Furuya A; Kuro-o M; Sata M; Nagai R. 2010. Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation 122(20):2048-57. [PubMed: 21041690] [MGI Ref ID J:179478]
Jensen KB; Collins CA; Nascimento E; Tan DW; Frye M; Itami S; Watt FM. 2009. Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell 4(5):427-39. [PubMed: 19427292] [MGI Ref ID J:149833]
Jiao JW; Feldheim DA; Chen DF. 2008. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. Proc Natl Acad Sci U S A 105(25):8778-83. [PubMed: 18562299] [MGI Ref ID J:137200]
Jost M; Maillard C; Lecomte J; Lambert V; Tjwa M; Blaise P; Alvarez Gonzalez ML; Bajou K; Blacher S; Motte P; Humblet C; Defresne MP; Thiry M; Frankenne F; Gothot A; Carmeliet P; Rakic JM; Foidart JM; Noel A. 2007. Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I. Am J Pathol 171(4):1369-80. [PubMed: 17717143] [MGI Ref ID J:125522]
Kataru RP; Jung K; Jang C; Yang H; Schwendener RA; Baik JE; Han SH; Alitalo K; Koh GY. 2009. Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 113(22):5650-9. [PubMed: 19346498] [MGI Ref ID J:148892]
Kawasaki T; Ito K; Hirata T. 2006. Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract. Development 133(5):845-53. [PubMed: 16439477] [MGI Ref ID J:106022]
Kim S; Roopra A; Alexander CM. 2012. A phenotypic mouse model of basaloid breast tumors. PLoS One 7(2):e30979. [PubMed: 22347416] [MGI Ref ID J:185233]
Kirberg J; Bosco N; Deloulme JC; Ceredig R; Agenes F. 2008. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection. J Immunol 181(2):1207-14. [PubMed: 18606674] [MGI Ref ID J:137464]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX1
Colony Maintenance
Breeding & Husbandry This strain is maintained by mating a hemizygous carrier with a C57BL/6J mouse. Mice homozygous for this transgene are not viable. Expected coat color from breeding:Black Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 5 weeks $251.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 6 weeks $256.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 7 weeks $261.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 8 weeks $266.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 9 weeks $271.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 10 weeks $276.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 11 weeks $281.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 12 weeks $286.90 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb
Price per Pair (US dollars $) Pair Genotype $277.30 C57BL/6J (000664) x Hemizygous for Tg(CAG-EGFP)1Osb $275.80 Hemizygous for Tg(CAG-EGFP)1Osb x C57BL/6J (000664) Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
- Strains that must be genotyped are not available until five to seven weeks of age.
| Pricing for International shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 5 weeks $327.50 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 6 weeks $334.00 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 7 weeks $340.50 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 8 weeks $347.00 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 9 weeks $353.50 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 10 weeks $360.00 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 11 weeks $366.50 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb 12 weeks $373.00 Female or Male Hemizygous for Tg(CAG-EGFP)1Osb
Price per Pair (US dollars $) Pair Genotype $360.50 C57BL/6J (000664) x Hemizygous for Tg(CAG-EGFP)1Osb $358.60 Hemizygous for Tg(CAG-EGFP)1Osb x C57BL/6J (000664) Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Strains that must be genotyped are not available until five to seven weeks of age.
- Strains that require genotyping are only offered at five weeks of age and older. The time required for sample collection, assay, reporting, and completion of USDA documentation required for international purchases make distribution of younger mice prohibitive. Mice at a precise age in days, littermates and retired breeders are also available. Mice older than 10 weeks of age can be requested by contacting JAX® Mice & Services.
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Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.