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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6;SWJ-TgN(TIMP3LacZ)7Jeb (Changed: 15-DEC-04 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Donating Investigator Jean Bennett, Scheie Eye Institute Description
These transgenic mice show no phenotypic defects. LacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. LacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated.
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (178 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
lacZ relatedResearch Tools
lacZ Expression
Genetics Research (Tissue/Cell Markers: multiple)
Reproductive Biology Research
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(TIMP3-lacZ)7Jeb | ||
|---|---|---|---|
| Allele Name | transgene insertion 7, Jean Bennett | ||
| Allele Type | Transgenic (Reporter) | ||
| Site of Expression | Eye, specifically in the corneal endothelium and ganglion cell layer, kidney, choroid plexus, testes and ovaries,gingiva, bone and the hair follicles of the skin. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Promoter | TIMP3, TIMP metallopeptidase inhibitor 3, human | ||
| General Note | Transgenic mice on a B6;SWJ background show no phenotypic defects. lacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. lacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated. | ||
| Molecular Note | The transgene contains the beta-galactosidase gene under control of the tissue inhibitor of metalloproteinase 3 (Timp3) promoter. [MGI Ref ID J:93002] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic LacZ Melt Curve Analysis, MCA, vers. 2
Generic LacZ, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Zeng Y; Rosborough RC; Li Y; Gupta AR; Bennett J. 1998. Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene. Dev Dyn 211(3):228-37. [PubMed: 9520110] [MGI Ref ID J:93002]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
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