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- Description
- Phenotype
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Description
Strain Information
Former Names BALB/c-Tg(DO11.10)10Loh/J (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Transgenic; Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain BALB/c Generation N15F?+19 (20-DEC-06) Donating Investigator Kenneth Murphy, Washingston Univ School of Medicine 
Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/TyrcDescription
Mice carrying the MHC class II restricted rearranged T cell receptor transgene, Tg(DO11.10)10Dlo, react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes within 20 hours of treatment indicates that apoptosis in important in the development of antigen-induced tolerance. Use of this rearranged T cell receptor transgene requires H2d background.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(DO11.10)10Dlo allele
003147 B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J View Strains carrying Tg(DO11.10)10Dlo (1 strain)
Additional Web Information
Congenic Nomenclature
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
Mammalian Phenotype Terms assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(DO11.10)10Dlo/?
Background Not Specified
- immune system phenotype
- abnormal thymus cellularity (MGI Ref ID J:70572)
- 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes
- apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas
- 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla
- peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8
- decreased CD4-positive T cell number (MGI Ref ID J:70572)
- CD4+ CD8- TCR
thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide- decreased double-positive T cell number (MGI Ref ID J:70572)
- CD4+CD8+TCR
cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide - hematopoietic system phenotype
- abnormal thymus cellularity (MGI Ref ID J:70572)
- 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes
- apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas
- 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla
- peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8
- decreased CD4-positive T cell number (MGI Ref ID J:70572)
- CD4+ CD8- TCR
thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide- decreased double-positive T cell number (MGI Ref ID J:70572)
- CD4+CD8+TCR
cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide Research Applications
This mouse can be used to support research in many areas including:
Tcra relatedImmunology and Inflammation Research
Rearranged Antigen-Specific T Cell Receptor Transgenes (class II restricted)
Research Tools
Immunology and Inflammation Research (T Cell Receptor Transgenics)
Tcrb relatedHematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Research Tools
Cancer Research (specific T cell deficiency)
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(DO11.10)10Dlo | ||
|---|---|---|---|
| Allele Name | transgene insertion 10, Dennis Y Loh | ||
| Common Name(s) | CO11.10 TCR-alphabeta; DO-11.10; DO-Tg; DO.10 Tg; DO.11; DO.11.10 TCR; DO11; DO11 TCR; DO11.10; DO11.10 TCR; DO11.10 TCR Tg; DO11.10 alphabeta-TCR; DO11.10TCRalphabeta; Do11.10 alphabeta TCR; Do11.10 alphabetaTCR; OVA-TCRtg; Tg(DO11.10)Tcra/Tcrb; TgN(DO11.10)10Dlo; TgN(DO11.10)10Loh; | ||
| Mutation Made By | Dennis Loh, Hoffman LaRoche | ||
| Expressed Gene | Tcrb, T-cell receptor beta chain, mouse, laboratory | ||
| Expressed Gene | Tcra, T-cell receptor alpha chain, mouse, laboratory | ||
| General Note |
Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment. | ||
| Molecular Note | The transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor. [MGI Ref ID J:25536] [MGI Ref ID J:61321] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(DO11.10)10Dlo, QPCR, vers. 2
Tg(DO11.10)10Dlo, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Murphy KM; Heimberger AB; Loh DY. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250(4988):1720-3. [PubMed: 2125367] [MGI Ref ID J:70572]
Additional References
Chen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. [PubMed: 11514601] [MGI Ref ID J:71101]
Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121] [MGI Ref ID J:90986]
Tg(DO11.10)10Dlo related
Abarrategui I; Krangel MS. 2007. Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J 26(20):4380-90. [PubMed: 17882258] [MGI Ref ID J:128344]Agata Y; Tamaki N; Sakamoto S; Ikawa T; Masuda K; Kawamoto H; Murre C. 2007. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 27(6):871-84. [PubMed: 18093539] [MGI Ref ID J:129170]
Al-Shami A; Spolski R; Kelly J; Keane-Myers A; Leonard WJ. 2005. A role for TSLP in the development of inflammation in an asthma model. J Exp Med 202(6):829-39. [PubMed: 16172260] [MGI Ref ID J:107431]
Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712] [MGI Ref ID J:115475]
Aliahmad P; Kaye J. 2008. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 205(1):245-56. [PubMed: 18195075] [MGI Ref ID J:131287]
Ansel KM; Greenwald RJ; Agarwal S; Bassing CH; Monticelli S; Interlandi J; Djuretic IM; Lee DU; Sharpe AH; Alt FW; Rao A. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 5(12):1251-9. [PubMed: 15516924] [MGI Ref ID J:94039]
Artis D; Kane CM; Fiore J; Zaph C; Shapira S; Joyce K; Macdonald A; Hunter C; Scott P; Pearce EJ. 2005. Dendritic cell-intrinsic expression of NF-kappaB1 is required to promote optimal Th2 cell differentiation. J Immunol 174(11):7154-9. [PubMed: 15905559] [MGI Ref ID J:99003]
Au-Yeung BB; Katzman SD; Fowell DJ. 2006. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176(7):3895-9. [PubMed: 16547221] [MGI Ref ID J:129883]
Azzam HS; DeJarnette JB; Huang K; Emmons R; Park CS; Sommers CL; El-Khoury D; Shores EW; Love PE. 2001. Fine tuning of TCR signaling by CD5. J Immunol 166(9):5464-72. [PubMed: 11313384] [MGI Ref ID J:106735]
Banerjee D; Liou HC; Sen R. 2005. c-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity 23(4):445-58. [PubMed: 16226509] [MGI Ref ID J:113281]
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Berenson LS; Gavrieli M; Farrar JD; Murphy TL; Murphy KM. 2006. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol 177(8):5195-203. [PubMed: 17015705] [MGI Ref ID J:139447]
Berenson LS; Yang J; Sleckman BP; Murphy TL; Murphy KM. 2006. Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol 176(8):4616-21. [PubMed: 16585552] [MGI Ref ID J:131224]
Bommireddy R; Babcock GF; Singh RR; Doetschman T. 2008. TGFbeta1 deficiency does not affect the generation and maintenance of CD4(+)CD25(+)FOXP3(+) putative T(reg) cells, but causes their numerical inadequacy and loss of regulatory function. Clin Immunol 127(2):206-13. [PubMed: 18308639] [MGI Ref ID J:133597]
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Chikuma S; Abbas AK; Bluestone JA. 2005. B7-independent inhibition of T cells by CTLA-4. J Immunol 175(1):177-81. [PubMed: 15972645] [MGI Ref ID J:100562]
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