Strain Name:

C.Cg-Tg(DO11.10)10Dlo/J

Stock Number:

003303

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Availability:

Level 3

Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment. These mice may be useful for studies of T cell selection and death in immune responses and in the generation of tolerance, as well as for studying the mechanisms of apoptosis.

Description

Strain Information

Former Names BALB/c-Tg(DO11.10)10Loh/J    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
Background Strain BALB/c
GenerationN15F?+N3F9 (17-SEP-12)
Generation Definitions
 
Donating InvestigatorDr. Kenneth Murphy,   Washingston Univ School of Medicine

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Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
Mice carrying the MHC class II restricted rearranged T cell receptor transgene, Tg(DO11.10)10Dlo, react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes within 20 hours of treatment indicates that apoptosis in important in the development of antigen-induced tolerance. Use of this rearranged T cell receptor transgene requires H2d background.

Development
Constructs, about 45 to 50 kilobases, made from full genomic TCR rearranged genes from the DO11.10 hybridoma of Kappler and Marrack were co-microinjected into (B6C3F1) female X BALB male embryos. Founder mice were bred back to BALB/c. The Tg(DO11.10)10Dlo transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(DO11.10)10Dlo allele
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
View Strains carrying   Tg(DO11.10)10Dlo     (1 strain)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (46 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
002122   B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
002118   B6.129P2-Tcrbtm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007081   CByJ.129P2(B6)-Tcrbtm1Mom/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
023082   NOD.129P2(Cg)-Tcrbtm1Mom/MnkaJ
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (48 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(DO11.10)10Dlo/?

        Background Not Specified
  • immune system phenotype
  • abnormal thymus physiology
    • 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes   (MGI Ref ID J:70572)
    • apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas   (MGI Ref ID J:70572)
    • 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla   (MGI Ref ID J:70572)
    • peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8   (MGI Ref ID J:70572)
  • decreased CD4-positive T cell number
    • CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide   (MGI Ref ID J:70572)
  • decreased double-positive T cell number
    • CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide   (MGI Ref ID J:70572)
  • hematopoietic system phenotype
  • abnormal thymus physiology
    • 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes   (MGI Ref ID J:70572)
    • apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas   (MGI Ref ID J:70572)
    • 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla   (MGI Ref ID J:70572)
    • peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8   (MGI Ref ID J:70572)
  • decreased CD4-positive T cell number
    • CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide   (MGI Ref ID J:70572)
  • decreased double-positive T cell number
    • CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide   (MGI Ref ID J:70572)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Rearranged Antigen-Specific T Cell Receptor Transgenes
      class II restricted

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Transgenics

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(DO11.10)10Dlo
Allele Name transgene insertion 10, Dennis Y Loh
Allele Type Transgenic (random, expressed)
Common Name(s) CO11.10 TCR-alphabeta; DO-11.10; DO-Tg; DO.10 Tg; DO.11; DO.11.10 TCR; DO11; DO11 TCR; DO11.10; DO11.10 TCR; DO11.10 TCR Tg; DO11.10 alphabeta-TCR; DO11.10TCRalphabeta; Do11.10 alphabeta TCR; Do11.10 alphabetaTCR; OVA-TCRtg; Tg(DO11.10)Tcra/Tcrb; TgN(DO11.10)10Dlo; TgN(DO11.10)10Loh;
Mutation Made ByDr. Dennis Loh,   Hoffman LaRoche
Expressed Gene Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene Tcrb, T cell receptor beta chain, mouse, laboratory
Promoter Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter Tcrb, T cell receptor beta chain, mouse, laboratory
General Note

Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment.

Molecular Note The transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor. [MGI Ref ID J:25536] [MGI Ref ID J:61321]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(DO11.10)10Dlo-Tcra, Separated PCR
Tg(DO11.10)10Dlo-Tcrb QPCR, QPCR
Tg(DO11.10)10Dlo-Tcrb, Separated PCR
Tg(DO11.10)10Dlo, QPCR
Tg(DO11.10)10Dlo, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Murphy KM; Heimberger AB; Loh DY. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250(4988):1720-3. [PubMed: 2125367]  [MGI Ref ID J:70572]

Additional References

Chen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. [PubMed: 11514601]  [MGI Ref ID J:71101]

Parameswaran N; Samuvel DJ; Kumar R; Thatai S; Bal V; Rath S; George A. 2004. Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization. Infect Immun 72(7):3803-11. [PubMed: 15213121]  [MGI Ref ID J:90986]

Tg(DO11.10)10Dlo related

Abarrategui I; Krangel MS. 2007. Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J 26(20):4380-90. [PubMed: 17882258]  [MGI Ref ID J:128344]

Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. [PubMed: 19414806]  [MGI Ref ID J:148317]

Abe BT; Shin DS; Mocholi E; Macian F. 2012. NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res 72(18):4642-51. [PubMed: 22865456]  [MGI Ref ID J:191294]

Abe Y; Kamachi F; Kawamoto T; Makino F; Ito J; Kojima Y; Moustapha Ael D; Usui Y; Yagita H; Takasaki Y; Okumura K; Akiba H. 2013. TIM-4 has dual function in the induction and effector phases of murine arthritis. J Immunol 191(9):4562-72. [PubMed: 24068667]  [MGI Ref ID J:206248]

AbuAttieh M; Rebrovich M; Wettstein PJ; Vuk-Pavlovic Z; Limper AH; Platt JL; Cascalho M. 2007. Fitness of cell-mediated immunity independent of repertoire diversity. J Immunol 178(5):2950-60. [PubMed: 17312140]  [MGI Ref ID J:144104]

Agata Y; Tamaki N; Sakamoto S; Ikawa T; Masuda K; Kawamoto H; Murre C. 2007. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 27(6):871-84. [PubMed: 18093539]  [MGI Ref ID J:129170]

Al-Shami A; Spolski R; Kelly J; Keane-Myers A; Leonard WJ. 2005. A role for TSLP in the development of inflammation in an asthma model. J Exp Med 202(6):829-39. [PubMed: 16172260]  [MGI Ref ID J:107431]

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Alari-Pahissa E; Notario L; Lorente E; Vega-Ramos J; Justel A; Lopez D; Villadangos JA; Lauzurica P. 2012. CD69 does not affect the extent of T cell priming. PLoS One 7(10):e48593. [PubMed: 23119065]  [MGI Ref ID J:192275]

Albacker LA; Karisola P; Chang YJ; Umetsu SE; Zhou M; Akbari O; Kobayashi N; Baumgarth N; Freeman GJ; Umetsu DT; Dekruyff RH. 2010. TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells. J Immunol 185(11):6839-49. [PubMed: 21037090]  [MGI Ref ID J:166143]

Albrecht I; Niesner U; Janke M; Menning A; Loddenkemper C; Kuhl AA; Lepenies I; Lexberg MH; Westendorf K; Hradilkova K; Grun J; Hamann A; Epstein JA; Chang HD; Tokoyoda K; Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol 40(11):2993-3006. [PubMed: 21061432]  [MGI Ref ID J:167626]

Alegre ML; Shiels H; Thompson CB; Gajewski TF. 1998. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol 161(7):3347-56. [PubMed: 9759851]  [MGI Ref ID J:115196]

Aliahmad P; Kaye J. 2008. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 205(1):245-56. [PubMed: 18195075]  [MGI Ref ID J:131287]

Allenspach EJ; Cullinan P; Tong J; Tang Q; Tesciuba AG; Cannon JL; Takahashi SM; Morgan R; Burkhardt JK; Sperling AI. 2001. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15(5):739-50. [PubMed: 11728336]  [MGI Ref ID J:94032]

Ansel KM; Greenwald RJ; Agarwal S; Bassing CH; Monticelli S; Interlandi J; Djuretic IM; Lee DU; Sharpe AH; Alt FW; Rao A. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 5(12):1251-9. [PubMed: 15516924]  [MGI Ref ID J:94039]

Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L. 2007. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol 178(9):5912-20. [PubMed: 17442975]  [MGI Ref ID J:145827]

Artis D; Kane CM; Fiore J; Zaph C; Shapira S; Joyce K; Macdonald A; Hunter C; Scott P; Pearce EJ. 2005. Dendritic cell-intrinsic expression of NF-kappaB1 is required to promote optimal Th2 cell differentiation. J Immunol 174(11):7154-9. [PubMed: 15905559]  [MGI Ref ID J:99003]

Ashino S; Wakita D; Shiohama Y; Iwakura Y; Chamoto K; Ohkuri T; Kitamura H; Nishimura T. 2010. A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness. Int Immunol 22(6):503-13. [PubMed: 20501609]  [MGI Ref ID J:160594]

Atochina O; Da'dara AA; Walker M; Harn DA. 2008. The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo. Immunology 125(1):111-21. [PubMed: 18373667]  [MGI Ref ID J:142776]

Attridge K; Wang CJ; Wardzinski L; Kenefeck R; Chamberlain JL; Manzotti C; Kopf M; Walker LS. 2012. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood 119(20):4656-64. [PubMed: 22442347]  [MGI Ref ID J:185168]

Au-Yeung BB; Katzman SD; Fowell DJ. 2006. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176(7):3895-9. [PubMed: 16547221]  [MGI Ref ID J:129883]

Aubin E; Lemieux R; Bazin R. 2010. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 115(9):1727-34. [PubMed: 19965673]  [MGI Ref ID J:157778]

Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. [PubMed: 21824820]  [MGI Ref ID J:178253]

Avci FY; Li X; Tsuji M; Kasper DL. 2011. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12):1602-9. [PubMed: 22101769]  [MGI Ref ID J:179822]

Azzam HS; DeJarnette JB; Huang K; Emmons R; Park CS; Sommers CL; El-Khoury D; Shores EW; Love PE. 2001. Fine tuning of TCR signaling by CD5. J Immunol 166(9):5464-72. [PubMed: 11313384]  [MGI Ref ID J:106735]

Baba T; Badr Mel S; Tomaru U; Ishizu A; Mukaida N. 2012. Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpalpha+ dendritic cells: a murine model. PLoS One 7(7):e41154. [PubMed: 22815949]  [MGI Ref ID J:189603]

Baba T; Nakamoto Y; Mukaida N. 2009. Crucial contribution of thymic Sirpalpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 183(5):3053-63. [PubMed: 19675159]  [MGI Ref ID J:151848]

Bakocevic N; Worbs T; Davalos-Misslitz A; Forster R. 2010. T cell-dendritic cell interaction dynamics during the induction of respiratory tolerance and immunity. J Immunol 184(3):1317-27. [PubMed: 20042584]  [MGI Ref ID J:159503]

Balasubramani A; Shibata Y; Crawford GE; Baldwin AS; Hatton RD; Weaver CT. 2010. Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity 33(1):35-47. [PubMed: 20643337]  [MGI Ref ID J:162632]

Baldeviano GC; Barin JG; Talor MV; Srinivasan S; Bedja D; Zheng D; Gabrielson K; Iwakura Y; Rose NR; Cihakova D. 2010. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 106(10):1646-55. [PubMed: 20378858]  [MGI Ref ID J:172627]

Banerjee D; Liou HC; Sen R. 2005. c-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity 23(4):445-58. [PubMed: 16226509]  [MGI Ref ID J:113281]

Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. [PubMed: 22869892]  [MGI Ref ID J:191446]

Barin JG; Baldeviano GC; Talor MV; Wu L; Ong S; Quader F; Chen P; Zheng D; Caturegli P; Rose NR; Cihakova D. 2012. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol 42(3):726-36. [PubMed: 22161142]  [MGI Ref ID J:187791]

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Yang J; Yang M; Htut TM; Ouyang X; Hanidu A; Li X; Sellati R; Jiang H; Zhang S; Li H; Zhao J; Ting AT; Mayer L; Unkeless JC; Labadia ME; Hodge M; Li J; Xiong H. 2008. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgammat. Eur J Immunol 38(5):1204-14. [PubMed: 18412165]  [MGI Ref ID J:134148]

Yang Z; Zhang X; Darrah PA; Mosser DM. 2010. The Regulation of Th1 Responses by the p38 MAPK. J Immunol 185(10):6205-13. [PubMed: 20937847]  [MGI Ref ID J:165637]

Yao MW; Lim H; Schust DJ; Choe SE; Farago A; Ding Y; Michaud S; Church GM; Maas RL. 2003. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of hoxa-10 in the preimplantation uterus. Mol Endocrinol 17(4):610-27. [PubMed: 12554760]  [MGI Ref ID J:82683]

Yao W; Zhang Y; Jabeen R; Nguyen ET; Wilkes DS; Tepper RS; Kaplan MH; Zhou B. 2013. Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP. Immunity 38(2):360-72. [PubMed: 23376058]  [MGI Ref ID J:193619]

Yasuda T; Kuwabara T; Nakano H; Aritomi K; Onodera T; Lipp M; Takahama Y; Kakiuchi T. 2007. Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109(2):449-56. [PubMed: 16973962]  [MGI Ref ID J:144008]

Ye Q; Press B; Kissler S; Yang XF; Lu L; Bassing CH; Sleckman BP; Jansson M; Panoutsakopoulou V; Trimble LA; Alt FW; Cantor H. 2002. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med 196(1):87-95. [PubMed: 12093873]  [MGI Ref ID J:77507]

Yin X; Ladi E; Chan SW; Li O; Killeen N; Kappes DJ; Robey EA. 2007. CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. J Immunol 179(11):7358-64. [PubMed: 18025179]  [MGI Ref ID J:154818]

Yokota A; Takeuchi H; Maeda N; Ohoka Y; Kato C; Song SY; Iwata M. 2009. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol 21(4):361-77. [PubMed: 19190084]  [MGI Ref ID J:147108]

Yoshimoto M; Yoder MC; Guevara P; Adkins B. 2013. The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny. PLoS One 8(1):e51587. [PubMed: 23335954]  [MGI Ref ID J:195706]

Yoshimoto T; Min B; Sugimoto T; Hayashi N; Ishikawa Y; Sasaki Y; Hata H; Takeda K; Okumura K; Van Kaer L; Paul WE; Nakanishi K. 2003. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med 197(8):997-1005. [PubMed: 12695491]  [MGI Ref ID J:120694]

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Zahorsky-Reeves JL; Wilkinson JE. 2002. A transgenic mouse strain with antigen-specific T cells (RAG1KO/sf/OVA) demonstrates that the scurfy (sf) mutation causes a defect in T-cell tolerization. Comp Med 52(1):58-62. [PubMed: 11900414]  [MGI Ref ID J:120225]

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Zosky GR; Larcombe AN; White OJ; Burchell JT; von Garnier C; Holt PG; Turner DJ; Wikstrom ME; Sly PD; Stumbles PA. 2009. Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways. Am J Physiol Lung Cell Mol Physiol 297(2):L373-9. [PubMed: 19482896]  [MGI Ref ID J:151339]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $108.50Female or MaleHomozygous for Tg(DO11.10)10Dlo  
4 weeks $108.50Female or MaleHomozygous for Tg(DO11.10)10Dlo  
5 weeks $108.50Female or MaleHomozygous for Tg(DO11.10)10Dlo  
6 weeks $113.75Female or MaleHomozygous for Tg(DO11.10)10Dlo  
7 weeks $119.00Female or MaleHomozygous for Tg(DO11.10)10Dlo  
8 weeks $124.25Female or MaleHomozygous for Tg(DO11.10)10Dlo  
9 weeks $129.50Female or MaleHomozygous for Tg(DO11.10)10Dlo  
10 weeks $134.75Female or MaleHomozygous for Tg(DO11.10)10Dlo  
11 weeks $140.00Female or MaleHomozygous for Tg(DO11.10)10Dlo  
12 weeks $145.25Female or MaleHomozygous for Tg(DO11.10)10Dlo  
Price per Pair (US dollars $)Pair Genotype
$227.50Homozygous for Tg(DO11.10)10Dlo x Homozygous for Tg(DO11.10)10Dlo  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $141.10Female or MaleHomozygous for Tg(DO11.10)10Dlo  
4 weeks $141.10Female or MaleHomozygous for Tg(DO11.10)10Dlo  
5 weeks $141.10Female or MaleHomozygous for Tg(DO11.10)10Dlo  
6 weeks $147.90Female or MaleHomozygous for Tg(DO11.10)10Dlo  
7 weeks $154.70Female or MaleHomozygous for Tg(DO11.10)10Dlo  
8 weeks $161.60Female or MaleHomozygous for Tg(DO11.10)10Dlo  
9 weeks $168.40Female or MaleHomozygous for Tg(DO11.10)10Dlo  
10 weeks $175.20Female or MaleHomozygous for Tg(DO11.10)10Dlo  
11 weeks $182.00Female or MaleHomozygous for Tg(DO11.10)10Dlo  
12 weeks $188.90Female or MaleHomozygous for Tg(DO11.10)10Dlo  
Price per Pair (US dollars $)Pair Genotype
$295.80Homozygous for Tg(DO11.10)10Dlo x Homozygous for Tg(DO11.10)10Dlo  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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