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Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N4F10N1p Donating Investigator Philippe Soriano, Fred Hutchinson Cancer Research Center Appearance
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Related Genotype: a/aDescription
Mice heterozygous or homozygous for the Gtrosa26tm1Sor targeted mutation may be used to test the tissue/cellular expression pattern of the cre transgene in any transgenic strain carrying cre under the regulation of a specific promoter. Cre expression results in the removal of a loxP-flanked DNA segment that prevents expression of a lacZ gene. When crossed with a cre transgenic strain, lacZ is expressed in cells/tissues where cre is expressed.Development
The ROSA26 locus of a gene trap strain was targeted with a ROSA26 reporter (R26R) construct to generate a Cre reporter strain by homologous recombination in AK7 ES cells. The R26R construct was created by subcloning the pROSA26-1 vector, and inserting a splice acceptor sequence (identical to the one used in the original gene trap allele), a neo expression cassette flanked by loxP sites, a lacZ gene and a polyadenylation sequence at a unique site approximately 300-bp 5' of the original gene trap integration site. Transcriptional read-through was prevented with the use of a triple polyadenylation sequence at the 3' end of the neo expression cassette.
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
lacZ Expression Strains
View lacZ Expression Strains (178 strains)
Strains carrying Gt(ROSA)26Sortm1Sor allele
003310 129S-Gt(ROSA)26Sortm1Sor/J 003474 B6.129S4-Gt(ROSA)26Sortm1Sor/J View Strains carrying Gt(ROSA)26Sortm1Sor (2 strains)
Strains carrying other alleles of Gt(ROSA)26Sor
View Strains carrying other alleles of Gt(ROSA)26Sor (47 strains)
Strains carrying other alleles of lacZ
View Strains carrying other alleles of lacZ (34 strains)
Cre-lox Systems
Fluorescent Proteins/lacZ Systems
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
involves: 129S4/SvJaeSor
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:64292)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
lacZ relatedResearch Tools
lacZ Expression
Cre-lox System (loxP-flanked Sequences: Test/Reporter)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene)
Genetics Research (Tissue/Cell Markers: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene)
Research Tools
lacZ Expression
| Allele Symbol | Gt(ROSA)26Sortm1Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Gt(ROSA)26Sor; Gtrosa26tm/Sor; Gtrosa26tm1Sor; R26LacZ; R26R; R26R-lacZ; R26RLacZ; ROSA26-LacZ; ROSA26-loxP; ROSA26fl; ROSA26R; ROSA26Rflox; Rosa26 cre reporter; Rosa26-LoxSTOPLox-LacZ; Rosa26-lacZ cre reporter; Rosa26LacZ; Rosa26stop-LacZ; Rosa26R-lacZ; Rosa26RLacZ; Rosa26RlacZ; Rosa26r-; RosaLoxP; loxP-Stop-loxP lacZ reporter; | ||
| Mutation Made By | Philippe Soriano, Fred Hutchinson Cancer Research Center | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | when crossed to a Cre recombinase-expressing strain, lacZ expression is observed in the cre-expressing tissues | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| Molecular Note | A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a Cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. [MGI Ref ID J:64292] [MGI Ref ID J:92442] | ||
Genotyping Protocols
Gt(ROSA)26Sortm1Sor, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
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