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- Description
- Phenotype
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N4F10N1p Donating Investigator Philippe Soriano, Fred Hutchinson Cancer Research Center Appearance
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Related Genotype: a/aDescription
Mice heterozygous or homozygous for the Gtrosa26tm1Sor targeted mutation may be used to test the tissue/cellular expression pattern of the cre transgene in any transgenic strain carrying cre under the regulation of a specific promoter. Cre expression results in the removal of a loxP-flanked DNA segment that prevents expression of a lacZ gene. When crossed with a cre transgenic strain, lacZ is expressed in cells/tissues where cre is expressed.Development
The ROSA26 locus of a gene trap strain was targeted with a ROSA26 reporter (R26R) construct to generate a Cre reporter strain by homologous recombination in AK7 ES cells. The R26R construct was created by subcloning the pROSA26-1 vector, and inserting a splice acceptor sequence (identical to the one used in the original gene trap allele), a neo expression cassette flanked by loxP sites, a lacZ gene and a polyadenylation sequence at a unique site approximately 300-bp 5' of the original gene trap integration site. Transcriptional read-through was prevented with the use of a triple polyadenylation sequence at the 3' end of the neo expression cassette.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (183 strains)
003310 129S-Gt(ROSA)26Sortm1Sor/J 003474 B6.129S4-Gt(ROSA)26Sortm1Sor/J 009427 FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
Additional Web Information
Cre-lox Systems
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
involves: 129S4/SvJaeSor
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:64292)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gt(ROSA)26Sortm1Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Gt(ROSA)26Sor; Gtrosa26tm/Sor; Gtrosa26tm1Sor; R26-Cond-lacZ; R26-floxstop-lacZ; R26LacZ; R26R; R26R-lacZ; R26RLacZ; ROSA26-LacZ; ROSA26-loxP; ROSA26fl; ROSA26R; ROSA26Rflox; Rosa26 cre reporter; Rosa26-LoxSTOPLox-LacZ; Rosa26-lacZ cre reporter; Rosa26LacZ; Rosa26stop-LacZ; Rosa26R-lacZ; Rosa26RLacZ; Rosa26RlacZ; Rosa26r-; RosaLoxP; loxP-Stop-loxP lacZ reporter; | ||
| Mutation Made By | Philippe Soriano, Mount Sinai School of Medicine | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | when crossed to a Cre recombinase-expressing strain, lacZ expression is observed in the cre-expressing tissues | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| Molecular Note | A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a Cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. [MGI Ref ID J:64292] [MGI Ref ID J:92442] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sortm1Sor, STD PCR, vers. 1
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain [letter] Nat Genet 21(1):70-1. [PubMed: 9916792] [MGI Ref ID J:64292]
Additional References
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Ruppel KM; Willison D; Kataoka H; Wang A; Zheng YW; Cornelissen I; Yin L; Xu SM; Coughlin SR. 2005. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A 102(23):8281-6. [PubMed: 15919816] [MGI Ref ID J:99731]
Schneider A; Zhang Y; Guan Y; Davis LS; Breyer MD. 2003. Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice. Am J Physiol Renal Physiol 284(2):F411-7. [PubMed: 12529277] [MGI Ref ID J:83044]
Shao X; Somlo S; Igarashi P. 2002. Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 13(7):1837-46. [PubMed: 12089379] [MGI Ref ID J:82531]
Theis M; de Wit C; Schlaeger TM; Eckardt D; Kruger O; Doring B; Risau W; Deutsch U; Pohl U; Willecke K. 2001. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 29(1):1-13. [PubMed: 11135457] [MGI Ref ID J:78662]
Gt(ROSA)26Sortm1Sor relatedAbe M; Ruest LB; Clouthier DE. 2007. Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice. Int J Dev Biol 51(2):97-105. [PubMed: 17294360] [MGI Ref ID J:118663]
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Agarwal N; Offermanns S; Kuner R. 2004. Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis 38(3):122-9. [PubMed: 15048809] [MGI Ref ID J:89764]
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Akimoto M; Filippova E; Gage PJ; Zhu X; Craft CM; Swaroop A. 2004. Transgenic mice expressing Cre-recombinase specifically in M- or S-cone photoreceptors. Invest Ophthalmol Vis Sci 45(1):42-7. [PubMed: 14691152] [MGI Ref ID J:87301]
Akyol A; Hinoi T; Feng Y; Bommer GT; Glaser TM; Fearon ER. 2008. Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods 5(3):231-3. [PubMed: 18264107] [MGI Ref ID J:148161]
Algul H; Treiber M; Lesina M; Nakhai H; Saur D; Geisler F; Pfeifer A; Paxian S; Schmid RM. 2007. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest 117(6):1490-501. [PubMed: 17525802] [MGI Ref ID J:122194]
Alizadeh A; Fitch KR; Niswender CM; McKnight GS; Barsh GS. 2008. Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements. Pigment Cell Melanoma Res 21(1):63-9. [PubMed: 18353144] [MGI Ref ID J:132975]
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Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
Andoniadou CL; Signore M; Sajedi E; Gaston-Massuet C; Kelberman D; Burns AJ; Itasaki N; Dattani M; Martinez-Barbera JP. 2007. Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development 134(8):1499-508. [PubMed: 17360769] [MGI Ref ID J:135132]
Anthony TE; Klein C; Fishell G; Heintz N. 2004. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881-90. [PubMed: 15046721] [MGI Ref ID J:89775]
Armaka M; Apostolaki M; Jacques P; Kontoyiannis DL; Elewaut D; Kollias G. 2008. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205(2):331-7. [PubMed: 18250193] [MGI Ref ID J:131930]
Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Arnold SJ; Huang GJ; Cheung AF; Era T; Nishikawa S; Bikoff EK; Molnar Z; Robertson EJ; Groszer M. 2008. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev 22(18):2479-84. [PubMed: 18794345] [MGI Ref ID J:138764]
Asano T; Niimura F; Pastan I; Fogo AB; Ichikawa I; Matsusaka T. 2005. Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. J Am Soc Nephrol 16(8):2257-62. [PubMed: 15987751] [MGI Ref ID J:126591]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Backman M; Machon O; Mygland L; van den Bout CJ; Zhong W; Taketo MM; Krauss S. 2005. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1):155-68. [PubMed: 15708565] [MGI Ref ID J:96233]
Balordi F; Fishell G. 2007. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci 27(52):14248-59. [PubMed: 18160632] [MGI Ref ID J:130973]
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Banares S; Zeh K; Krajewska M; Kermer P; Baribault H; Reed JC; Krajewski S. 2005. Novel pan-neuronal Cre-transgenic line for conditional ablation of genes in the nervous system. Genesis 42(1):6-16. [PubMed: 15828007] [MGI Ref ID J:99342]
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Bierie B; Stover DG; Abel TW; Chytil A; Gorska AE; Aakre M; Forrester E; Yang L; Wagner KU; Moses HL. 2008. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res 68(6):1809-19. [PubMed: 18339861] [MGI Ref ID J:133311]
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Bradley CK; Takano EA; Hall MA; Gothert JR; Harvey AR; Begley CG; van Eekelen JA. 2006. The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci 23(7):1677-89. [PubMed: 16623824] [MGI Ref ID J:108070]
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Cai CL; Martin JC; Sun Y; Cui L; Wang L; Ouyang K; Yang L; Bu L; Liang X; Zhang X; Stallcup WB; Denton CP; McCulloch A; Chen J; Evans SM. 2008. A myocardial lineage derives from Tbx18 epicardial cells. Nature 454(7200):104-8. [PubMed: 18480752] [MGI Ref ID J:137459]
Cali G; Zannini M; Rubini P; Tacchetti C; D'Andrea B; Affuso A; Wintermantel T; Boussadia O; Terracciano D; Silberschmidt D; Amendola E; De Felice M; Schutz G; Kemler R; Di Lauro R; Nitsch L. 2007. Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation. Endocrinology 148(6):2737-46. [PubMed: 17347311] [MGI Ref ID J:122323]
Calmont A; Wandzioch E; Tremblay KD; Minowada G; Kaestner KH; Martin GR; Zaret KS. 2006. An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell 11(3):339-48. [PubMed: 16950125] [MGI Ref ID J:112804]
Carriere C; Seeley ES; Goetze T; Longnecker DS; Korc M. 2007. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 104(11):4437-42. [PubMed: 17360542] [MGI Ref ID J:120054]
Casper KB; Jones K; McCarthy KD. 2007. Characterization of astrocyte-specific conditional knockouts. Genesis 45(5):292-9. [PubMed: 17457931] [MGI Ref ID J:121777]
Caulin C; Nguyen T; Longley MA; Zhou Z; Wang XJ; Roop DR. 2004. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res 64(15):5054-8. [PubMed: 15289303] [MGI Ref ID J:91877]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Chang W; Lin Z; Kulessa H; Hebert J; Hogan BL; Wu DK. 2008. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet 4(4):e1000050. [PubMed: 18404215] [MGI Ref ID J:136636]
Charles MA; Mortensen AH; Potok MA; Camper SA. 2008. Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility. Genesis 46(10):507-14. [PubMed: 18802953] [MGI Ref ID J:142726]
Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. [PubMed: 17582330] [MGI Ref ID J:126581]
Chen J; Kwon CH; Lin L; Li Y; Parada LF. 2009. Inducible site-specific recombination in neural stem/progenitor cells. Genesis 47(2):122-31. [PubMed: 19117051] [MGI Ref ID J:147310]
Chen L; Guo Q; Li JY. 2009. Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development 136(8):1317-26. [PubMed: 19279136] [MGI Ref ID J:147282]
Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. [PubMed: 17601530] [MGI Ref ID J:124119]
Chen YT; Liu P; Bradley A. 2004. Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes. Mol Cell Biol 24(22):9930-41. [PubMed: 15509795] [MGI Ref ID J:94223]
Cheon SS; Wei Q; Gurung A; Youn A; Bright T; Poon R; Whetstone H; Guha A; Alman BA. 2006. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J 20(6):692-701. [PubMed: 16581977] [MGI Ref ID J:129713]
Chi CL; Martinez S; Wurst W; Martin GR. 2003. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130(12):2633-44. [PubMed: 12736208] [MGI Ref ID J:83255]
Chizhikov VV; Lindgren AG; Currle DS; Rose MF; Monuki ES; Millen KJ. 2006. The roof plate regulates cerebellar cell-type specification and proliferation. Development 133(15):2793-804. [PubMed: 16790481] [MGI Ref ID J:119033]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
Choudhary B; Zhou J; Li P; Thomas S; Kaartinen V; Sucov HM. 2009. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47(2):115-21. [PubMed: 19165826] [MGI Ref ID J:147389]
Christoffels VM; Grieskamp T; Norden J; Mommersteeg MT; Rudat C; Kispert A. 2009. Tbx18 and the fate of epicardial progenitors. Nature 458(7240):E8-9; discussion E9-10. [PubMed: 19369973] [MGI Ref ID J:147421]
Christoffels VM; Mommersteeg MT; Trowe MO; Prall OW; de Gier-de Vries C; Soufan AT; Bussen M; Schuster-Gossler K; Harvey RP; Moorman AF; Kispert A. 2006. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res 98(12):1555-63. [PubMed: 16709898] [MGI Ref ID J:122633]
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| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.