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Description
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N4F10N1p Donating Investigator Philippe Soriano, Fred Hutchinson Cancer Research Center Appearance
black
Related Genotype: a/aDescription
Mice heterozygous or homozygous for the Gtrosa26tm1Sor targeted mutation may be used to test the tissue/cellular expression pattern of the cre transgene in any transgenic strain carrying cre under the regulation of a specific promoter. Cre expression results in the removal of a loxP-flanked DNA segment that prevents expression of a lacZ gene. When crossed with a cre transgenic strain, lacZ is expressed in cells/tissues where cre is expressed.Development
The ROSA26 locus of a gene trap strain was targeted with a ROSA26 reporter (R26R) construct to generate a Cre reporter strain by homologous recombination in AK7 ES cells. The R26R construct was created by subcloning the pROSA26-1 vector, and inserting a splice acceptor sequence (identical to the one used in the original gene trap allele), a neo expression cassette flanked by loxP sites, a lacZ gene and a polyadenylation sequence at a unique site approximately 300-bp 5' of the original gene trap integration site. Transcriptional read-through was prevented with the use of a triple polyadenylation sequence at the 3' end of the neo expression cassette.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (178 strains)
003310 129S-Gt(ROSA)26Sortm1Sor/J 003474 B6.129S4-Gt(ROSA)26Sortm1Sor/J
Additional Web Information
Cre-lox Systems
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
involves: 129S4/SvJaeSor
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:64292)
This mouse can be used to support research in many areas including:
lacZ relatedResearch Tools
lacZ Expression
Cre-lox System (loxP-flanked Sequences: Test/Reporter)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene)
Genetics Research (Tissue/Cell Markers: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene)
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gt(ROSA)26Sortm1Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Gt(ROSA)26Sor; Gtrosa26tm/Sor; Gtrosa26tm1Sor; R26LacZ; R26R; R26R-lacZ; R26RLacZ; ROSA26-LacZ; ROSA26-loxP; ROSA26fl; ROSA26R; ROSA26Rflox; Rosa26 cre reporter; Rosa26-LoxSTOPLox-LacZ; Rosa26-lacZ cre reporter; Rosa26LacZ; Rosa26stop-LacZ; Rosa26R-lacZ; Rosa26RLacZ; Rosa26RlacZ; Rosa26r-; RosaLoxP; loxP-Stop-loxP lacZ reporter; | ||
| Mutation Made By | Philippe Soriano, Fred Hutchinson Cancer Research Center | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | when crossed to a Cre recombinase-expressing strain, lacZ expression is observed in the cre-expressing tissues | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| Molecular Note | A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a Cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. [MGI Ref ID J:64292] [MGI Ref ID J:92442] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sortm1Sor, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain [letter] Nat Genet 21(1):70-1. [PubMed: 9916792] [MGI Ref ID J:64292]
Additional References
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Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
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Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Arnold SJ; Huang GJ; Cheung AF; Era T; Nishikawa S; Bikoff EK; Molnar Z; Robertson EJ; Groszer M. 2008. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev 22(18):2479-84. [PubMed: 18794345] [MGI Ref ID J:138764]
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Backman M; Machon O; Mygland L; van den Bout CJ; Zhong W; Taketo MM; Krauss S. 2005. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1):155-68. [PubMed: 15708565] [MGI Ref ID J:96233]
Balordi F; Fishell G. 2007. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci 27(52):14248-59. [PubMed: 18160632] [MGI Ref ID J:130973]
Bamji SX; Shimazu K; Kimes N; Huelsken J; Birchmeier W; Lu B; Reichardt LF. 2003. Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40(4):719-31. [PubMed: 14622577] [MGI Ref ID J:86623]
Banares S; Zeh K; Krajewska M; Kermer P; Baribault H; Reed JC; Krajewski S. 2005. Novel pan-neuronal Cre-transgenic line for conditional ablation of genes in the nervous system. Genesis 42(1):6-16. [PubMed: 15828007] [MGI Ref ID J:99342]
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Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
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Calmont A; Wandzioch E; Tremblay KD; Minowada G; Kaestner KH; Martin GR; Zaret KS. 2006. An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell 11(3):339-48. [PubMed: 16950125] [MGI Ref ID J:112804]
Carriere C; Seeley ES; Goetze T; Longnecker DS; Korc M. 2007. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 104(11):4437-42. [PubMed: 17360542] [MGI Ref ID J:120054]
Casper KB; Jones K; McCarthy KD. 2007. Characterization of astrocyte-specific conditional knockouts. Genesis 45(5):292-9. [PubMed: 17457931] [MGI Ref ID J:121777]
Caulin C; Nguyen T; Longley MA; Zhou Z; Wang XJ; Roop DR. 2004. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res 64(15):5054-8. [PubMed: 15289303] [MGI Ref ID J:91877]
Chang W; Lin Z; Kulessa H; Hebert J; Hogan BL; Wu DK. 2008. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet 4(4):e1000050. [PubMed: 18404215] [MGI Ref ID J:136636]
Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. [PubMed: 17582330] [MGI Ref ID J:126581]
Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. [PubMed: 17601530] [MGI Ref ID J:124119]
Chen YT; Liu P; Bradley A. 2004. Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes. Mol Cell Biol 24(22):9930-41. [PubMed: 15509795] [MGI Ref ID J:94223]
Cheon SS; Wei Q; Gurung A; Youn A; Bright T; Poon R; Whetstone H; Guha A; Alman BA. 2006. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J 20(6):692-701. [PubMed: 16581977] [MGI Ref ID J:129713]
Chi CL; Martinez S; Wurst W; Martin GR. 2003. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130(12):2633-44. [PubMed: 12736208] [MGI Ref ID J:83255]
Chizhikov VV; Lindgren AG; Currle DS; Rose MF; Monuki ES; Millen KJ. 2006. The roof plate regulates cerebellar cell-type specification and proliferation. Development 133(15):2793-804. [PubMed: 16790481] [MGI Ref ID J:119033]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
Christoffels VM; Mommersteeg MT; Trowe MO; Prall OW; de Gier-de Vries C; Soufan AT; Bussen M; Schuster-Gossler K; Harvey RP; Moorman AF; Kispert A. 2006. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res 98(12):1555-63. [PubMed: 16709898] [MGI Ref ID J:122633]
Claxton S; Kostourou V; Jadeja S; Chambon P; Hodivala-Dilke K; Fruttiger M. 2008. Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis 46(2):74-80. [PubMed: 18257043] [MGI Ref ID J:135315]
Colak D; Mori T; Brill MS; Pfeifer A; Falk S; Deng C; Monteiro R; Mummery C; Sommer L; Gotz M. 2008. Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci 28(2):434-46. [PubMed: 18184786] [MGI Ref ID J:131092]
Coppola V; Barrick CA; Southon EA; Celeste A; Wang K; Chen B; Haddad el-B; Yin J; Nussenzweig A; Subramaniam A; Tessarollo L. 2004. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131(20):5185-95. [PubMed: 15459109] [MGI Ref ID J:93578]
Cuellar TL; Davis TH; Nelson PT; Loeb GB; Harfe BD; Ullian E; McManus MT. 2008. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A 105(14):5614-9. [PubMed: 18385371] [MGI Ref ID J:133780]
Currle DS; Cheng X; Hsu CM; Monuki ES. 2005. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. Development 132(15):3549-59. [PubMed: 15975937] [MGI Ref ID J:100435]
Damiani D; Alexander JJ; O'Rourke JR; McManus M; Jadhav AP; Cepko CL; Hauswirth WW; Harfe BD; Strettoi E. 2008. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 28(19):4878-87. [PubMed: 18463241] [MGI Ref ID J:135193]
Davis MA; Reynolds AB. 2006. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell 10(1):21-31. [PubMed: 16399075] [MGI Ref ID J:105283]
Davis S; Miura S; Hill C; Mishina Y; Klingensmith J. 2004. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 270(1):47-63. [PubMed: 15136140] [MGI Ref ID J:92179]
De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3(1):e1516. [PubMed: 18231602] [MGI Ref ID J:131535]
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