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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N?+5p
Generation DefinitionsDonating Investigator Philippe Soriano, Mount Sinai School of Medicine Appearance
white-bellied agouti
Related Genotype: Aw/AwDescription
Mice heterozygous or homozygous for the Gtrosa26tm1Sor targeted mutation may be used to test the tissue/cellular expression pattern of the cre transgene in any transgenic strain carrying cre under the regulation of a specific promoter. Cre expression results in the removal of a loxP-flanked DNA segment that prevents expression of a lacZ gene. When crossed with a cre transgenic strain, lacZ is expressed in cells/tissues where cre is expressed. The 129-Gtrosa26tm1Sor strain is particularly useful for this purpose because the ROSA26 promoter leads to generalized expression of lacZ during development or in the adult.Development
The ROSA26 locus of a gene trap strain was targeted with a ROSA26 reporter (R26R) construct to generate a Cre reporter strain by homologous recombination in 129S4/SvJaeSor-derived AK7 ES cells. The R26R construct was created by subcloning the pROSA26-1 vector, and inserting a splice acceptor sequence (identical to the one used in the original gene trap allele), a neo expression cassette flanked by loxP sites, a lacZ gene and a polyadenylation sequence at a unique site approximately 300-bp 5' of the original gene trap integration site. Transcriptional read-through was prevented with the use of a triple polyadenylation sequence at the 3' end of the neo expression cassette. Upon arrival at The Jackson Laboratory, mutant mice were crossed to Stock No. 002448 (129S1/SvImJ) for more than 6 generations.
Control Information
| Control | ||
|---|---|---|
| See control note: | Wildtype mice from the colony should be used as controls. 129S3/SvImJ mice (Stock No. 002448) may serve as an approximate control as the Gtrosa26tm1Sor targeted mutation is currently being backcrossed to this strain (currently N?+1). The background of the original imported strain was 129S4/SvJaeSor which is a match to the AK7 ES cell line used. | |
| Wild-type from the colony | ||
| 002448 129S1/SvImJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (245 strains)
003474 B6.129S4-Gt(ROSA)26Sortm1Sor/J 003309 B6;129S4-Gt(ROSA)26Sortm1Sor/J 009427 FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
New 129 Nomenclature Bulletin
Phenotype
Phenotype Information
assigned by genotype
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
involves: 129S4/SvJaeSor
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:64292)
This mouse can be used to support research in many areas including:
Research Tools
lacZ Expression
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System: ubiquitously expressed lox-STOP-lox-LacZ transgene
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Gt(ROSA)26Sortm1Sor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Philippe Soriano | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Gt(ROSA)26Sor; Gt(ROSA)26Sortm1(LacZ)Cos; Gtrosa26tm/Sor; Gtrosa26tm1Sor; LSL-LacZ; R26-Cond-lacZ; R26-LNL-LacZ; R26-floxstop-lacZ; R26LacZ; R26R; R26R-lacZ; R26RLacZ; R26RZ; ROSA26-LacZ; ROSA26-flox-STOP-flox-lacZ; ROSA26-loxP; ROSA26::LNL::LacZ; ROSA26fl; ROSA26R; ROSA26Rflox; ROSA26XneorXlacZ; Rosa-LoxP-Stop-LoxP-LacZ; Rosa26 cre reporter; Rosa26-LacZloxP; Rosa26-LoxSTOPLox-LacZ; Rosa26-lacZ cre reporter; Rosa26LacZ; Rosa26stop-LacZ; Rosa26R-lacZ; Rosa26RLacZ; Rosa26RlacZ; Rosa26loxP-STOP-lacZ; Rosa26r-; RosaLoxP; loxP-Stop-loxP lacZ reporter; | ||
| Mutation Made By | Philippe Soriano, Mount Sinai School of Medicine | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | when crossed to a Cre recombinase-expressing strain, lacZ expression is observed in the cre-expressing tissues | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Molecular Note | A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. [MGI Ref ID J:64292] [MGI Ref ID J:94076] | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
References
References provided by MGI
Selected Reference(s)
Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain [letter] Nat Genet 21(1):70-1. [PubMed: 9916792] [MGI Ref ID J:64292]
Additional References
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Ruest LB; Dager M; Yanagisawa H; Charite J; Hammer RE; Olson EN; Yanagisawa M; Clouthier DE. 2003. Dhand-cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev Biol 257(2):263-77. [PubMed: 12729557] [MGI Ref ID J:83364]
Ruest LB; Hammer RE; Yanagisawa M; Clouthier DE. 2003. Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis 37(4):188-94. [PubMed: 14666512] [MGI Ref ID J:87355]
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Bao X; Moseman EA; Saito H; Petryanik B; Thiriot A; Hatakeyama S; Ito Y; Kawashima H; Yamaguchi Y; Lowe JB; von Andrian UH; Fukuda M. 2010. Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity 33(5):817-29. [PubMed: 21093315] [MGI Ref ID J:167007]
Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
Baranova O; Miranda LF; Pichiule P; Dragatsis I; Johnson RS; Chavez JC. 2007. Neuron-specific inactivation of the hypoxia inducible factor 1alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 27(23):6320-32. [PubMed: 17554006] [MGI Ref ID J:121971]
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Barnabe-Heider F; Goritz C; Sabelstrom H; Takebayashi H; Pfrieger FW; Meletis K; Frisen J. 2010. Origin of new glial cells in intact and injured adult spinal cord. Cell Stem Cell 7(4):470-82. [PubMed: 20887953] [MGI Ref ID J:165657]
Barnes RM; Firulli BA; Conway SJ; Vincentz JW; Firulli AB. 2010. Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn 239(11):3086-97. [PubMed: 20882677] [MGI Ref ID J:165398]
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Battiste J; Helms AW; Kim EJ; Savage TK; Lagace DC; Mandyam CD; Eisch AJ; Miyoshi G; Johnson JE. 2007. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 134(2):285-93. [PubMed: 17166924] [MGI Ref ID J:117032]
Bazigou E; Xie S; Chen C; Weston A; Miura N; Sorokin L; Adams R; Muro AF; Sheppard D; Makinen T. 2009. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell 17(2):175-86. [PubMed: 19686679] [MGI Ref ID J:152968]
Behr B; Panetta NJ; Longaker MT; Quarto N. 2010. Different endogenous threshold levels of Fibroblast Growth Factor-ligands determine the healing potential of frontal and parietal bones. Bone 47(2):281-94. [PubMed: 20472108] [MGI Ref ID J:163361]
Behr R; Sackett SD; Bochkis IM; Le PP; Kaestner KH. 2007. Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. Dev Biol 306(2):636-45. [PubMed: 17488644] [MGI Ref ID J:134427]
Belforte JE; Zsiros V; Sklar ER; Jiang Z; Yu G; Li Y; Quinlan EM; Nakazawa K. 2010. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci 13(1):76-83. [PubMed: 19915563] [MGI Ref ID J:156785]
Belvindrah R; Graus-Porta D; Goebbels S; Nave KA; Muller U. 2007. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27(50):13854-65. [PubMed: 18077697] [MGI Ref ID J:130562]
Benninger Y; Thurnherr T; Pereira JA; Krause S; Wu X; Chrostek-Grashoff A; Herzog D; Nave KA; Franklin RJ; Meijer D; Brakebusch C; Suter U; Relvas JB. 2007. Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol 177(6):1051-61. [PubMed: 17576798] [MGI Ref ID J:134927]
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885] [MGI Ref ID J:150767]
Bergami M; Rimondini R; Santi S; Blum R; Gotz M; Canossa M. 2008. Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci U S A 105(40):15570-5. [PubMed: 18832146] [MGI Ref ID J:143452]
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