Strain Name:

B6.129S7-Ngftm1Gne/J

Stock Number:

003312

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.129S7-Ngfbtm1Gne/J    (Changed: 12-FEB-08 )
B6.129S7-Ngfbtm1Agt    (Changed: 15-DEC-04 )
B6.129S7-Ngfbtm1Gne    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2)
 
Donating InvestigatorDr. Heidi Phillips,   Genentech, Inc.

Description
Mice homozygous for the disrupted Ngfb gene are born alive, but are smaller, on average, than wild type or heterozygous individuals. They fail to thrive and have a life span of 4 weeks or less, often dying within the first three days of life. Mutant mice are developmentally delayed and exhibit severe cell loss in sympathetic ganglia. They exhibit a more selective cell loss in sensory ganglia, revealing a reduced number of small cells in the dorsal root ganglia (DRG) at 3 days of age, while large cell numbers in the DRG are comparable to wild type mice. Mutant mice also display a decreased responsiveness to pain in comparison to +/+ or +/- littermates. During the first month of life, survival of cholinergic neurons in the basal forebrain does not appear to be affected by absence of NGF, as these cells were observed to differentiate and maintain their phenotype throughout the life span of homozygous mutant mice. Mice heterozygous for the Ngfb gene disruption exhibit normal growth and development and breed normally.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Neuropathy, Hereditary Sensory and Autonomic, Type V; HSAN5   (NGF)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ngftm1Gne/Ngf+

        involves: 129S7/SvEvBrd * C57BL/6
  • behavior/neurological phenotype
  • abnormal pain threshold
    • mutants display a small but significant prolongation in tail flick test   (MGI Ref ID J:17792)
  • nervous system phenotype
  • dorsal root ganglion hypoplasia
    • mutants display a decrease in cell number in the dorsal root ganglia   (MGI Ref ID J:17792)
  • integument phenotype
  • abnormal pain threshold
    • mutants display a small but significant prolongation in tail flick test   (MGI Ref ID J:17792)

Ngftm1Gne/Ngftm1Gne

        involves: 129S7/SvEvBrd * C57BL/6
  • mortality/aging
  • partial postnatal lethality
    • some mutants die within the first 3 days of birth and others are able to ingest some food and survive 1-4 weeks   (MGI Ref ID J:17792)
  • behavior/neurological phenotype
  • abnormal gait
    • some mutants surviving the first week show mild gait abnormalities   (MGI Ref ID J:17792)
  • hypoalgesia
    • unresponsive to tactile stimuli, decrease pain responsiveness in tail flick test, absent pain responsiveness in tail pinch test   (MGI Ref ID J:17792)
  • tremors
    • some mutants surviving the first week develop a tremor, that is most evident during locomotion   (MGI Ref ID J:17792)
  • growth/size/body phenotype
  • decreased body size
    • smaller at birth   (MGI Ref ID J:17792)
    • decreased body weight
      • weights range from 75-95% of the mean weights of controls mutants fail to gain weight   (MGI Ref ID J:17792)
  • postnatal growth retardation
    • homozygotes that survive the first days of life gain weight more slowly and are developmentally delayed   (MGI Ref ID J:17792)
  • vision/eye phenotype
  • blepharoptosis
    • all mutants surviving until eye opening display ptosis   (MGI Ref ID J:17792)
  • delayed eyelid opening
    • delayed opening, blepharoptosis (droopy eyelid)   (MGI Ref ID J:17792)
  • nervous system phenotype
  • abnormal sensory neuron innervation pattern
    • absence of primary sensory afferents in the dermis, epidermis and dorsal horn of spinal cord   (MGI Ref ID J:17792)
  • abnormal sympathetic ganglion morphology   (MGI Ref ID J:17792)
    • absent superior cervical ganglion
      • by P14, superior cervical ganglia are not visible   (MGI Ref ID J:17792)
      • however, the nodose ganglia are normal   (MGI Ref ID J:17792)
    • small superior cervical ganglion
      • superior cervical ganglia are smaller at early postnatal times   (MGI Ref ID J:17792)
  • dorsal root ganglion hypoplasia
    • dorsal root ganglia at P3 contain fewer neuronal profiles; neuronal cell counts from the fourth and fifth lumbar (L4 and L5) ganglia show a 70% reduction   (MGI Ref ID J:17792)
    • lumbar or cervical dorsal root ganglia show a complete absence of small cells in the ganglia but no evidence of cell loss in the large range   (MGI Ref ID J:17792)
  • integument phenotype
  • abnormal hair growth
    • delayed hair growth   (MGI Ref ID J:17792)
  • hypoalgesia
    • unresponsive to tactile stimuli, decrease pain responsiveness in tail flick test, absent pain responsiveness in tail pinch test   (MGI Ref ID J:17792)

Ngftm1Gne/Ngftm1Gne

        involves: 129S7/SvEvBrd
  • nervous system phenotype
  • *normal* nervous system phenotype
    • despite defects in the dorsal root ganglion, mice exhibit normal peroneal nerves   (MGI Ref ID J:154926)
    • abnormal dorsal root ganglion morphology
      • at E14.5, small diameter neurons in the dorsal root ganglion are eliminated unlike in wild-type mice   (MGI Ref ID J:154926)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ngftm1Gne related

Cancer Research
Genes Regulating Growth and Proliferation
Growth Factors/Receptors/Cytokines

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Neurodegeneration
Neurodevelopmental Defects
Neurotrophic Factor Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ngftm1Gne
Allele Name targeted mutation 1, Genentech
Allele Type Targeted (Null/Knockout)
Common Name(s) NGF-; Ngfbtm1;
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Ngf, nerve growth factor
Chromosome 3
Gene Common Name(s) Beta-NGF; HSAN5; NGFB; Ngfb; nerve growth factor, beta;
Molecular Note Replacement of a 150 bp fragment of the Ngfb gene, including the exon IV splice acceptor site and 130-bp of NGF coding sequence including the translation start site, with a CMV-neomycin cassette. [MGI Ref ID J:17792]

Genotyping

Genotyping Information

Genotyping Protocols

Generic Neo Melt Curve Analysis, Melt Curve Analysis
Generic Neo Melt Curve Analysis, Melt Curve Analysis
Ngftm1Gne, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Crowley C; Spencer SD; Nishimura MC; Chen KS; Pitts-Meek S; Armanini MP; Ling LH; MacMahon SB; Shelton DL; Levinson AD; Phillips HS. 1994. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76(6):1001-11. [PubMed: 8137419]  [MGI Ref ID J:17792]

Additional References

Glebova NO; Ginty DD. 2004. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24(3):743-51. [PubMed: 14736860]  [MGI Ref ID J:87702]

Ngftm1Gne related

Andres R; Herraez-Baranda LA; Thompson J; Wyatt S; Davies AM. 2008. Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Neurosci Lett 431(3):241-6. [PubMed: 18162309]  [MGI Ref ID J:141631]

Brennan C; Rivas-Plata K; Landis SC. 1999. The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo. Nat Neurosci 2(8):699-705. [PubMed: 10412058]  [MGI Ref ID J:56521]

Chen KS; Nishimura MC; Armanini MP; Crowley C; Spencer SD; Phillips HS. 1997. Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci 17(19):7288-96. [PubMed: 9295375]  [MGI Ref ID J:43081]

Deppmann CD; Mihalas S; Sharma N; Lonze BE; Niebur E; Ginty DD. 2008. A model for neuronal competition during development. Science 320(5874):369-73. [PubMed: 18323418]  [MGI Ref ID J:133953]

Dissen GA; Romero C; Hirshfield AN; Ojeda SR. 2001. Nerve growth factor is required for early follicular development in the mammalian ovary. Endocrinology 142(5):2078-86. [PubMed: 11316775]  [MGI Ref ID J:69395]

Forgie A; Kuehnel F; Wyatt S; Davies AM. 2000. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. Eur J Neurosci 12(2):670-6. [PubMed: 10712647]  [MGI Ref ID J:89412]

Frade JM; Barde YA. 1999. Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. Development 126(4):683-90. [PubMed: 9895316]  [MGI Ref ID J:51990]

Francis N; Farinas I; Brennan C; Rivas-Plata K; Backus C; Reichardt L; Landis S. 1999. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors. Dev Biol 210(2):411-27. [PubMed: 10357900]  [MGI Ref ID J:69120]

Fundin BT; Silos-Santiago I; Ernfors P; Fagan AM; Aldskogius H ; DeChiara TM ; Phillips HS ; Barbacid M ; Yancopoulos GD ; Rice FL. 1997. Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol 190(1):94-116. [PubMed: 9331334]  [MGI Ref ID J:43425]

Glebova NO; Ginty DD. 2004. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24(3):743-51. [PubMed: 14736860]  [MGI Ref ID J:87702]

Guo T; Mandai K; Condie BG; Wickramasinghe SR; Capecchi MR; Ginty DD. 2011. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci 14(1):31-6. [PubMed: 21151121]  [MGI Ref ID J:170402]

Harrison SM; Davis BM; Nishimura M; Albers KM; Jones ME; Phillips HS. 2004. Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF. Brain Res Mol Brain Res 122(2):116-25. [PubMed: 15010204]  [MGI Ref ID J:91239]

Kerr B; Garcia-Rudaz C; Dorfman M; Paredes A; Ojeda SR. 2009. NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. Reproduction 138(1):131-40. [PubMed: 19357131]  [MGI Ref ID J:152505]

Lazaridis I; Charalampopoulos I; Alexaki VI; Avlonitis N; Pediaditakis I; Efstathopoulos P; Calogeropoulou T; Castanas E; Gravanis A. 2011. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol 9(4):e1001051. [PubMed: 21541365]  [MGI Ref ID J:173911]

Luo W; Wickramasinghe SR; Savitt JM; Griffin JW; Dawson TM; Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54(5):739-54. [PubMed: 17553423]  [MGI Ref ID J:126484]

Mandai K; Guo T; St Hillaire C; Meabon JS; Kanning KC; Bothwell M; Ginty DD. 2009. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63(5):614-27. [PubMed: 19755105]  [MGI Ref ID J:154926]

Middleton G; Davies AM. 2001. Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development 128(23):4715-28. [PubMed: 11731452]  [MGI Ref ID J:72722]

Oh WJ; Gu C. 2013. Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron 80(2):458-69. [PubMed: 24139045]  [MGI Ref ID J:207212]

Patel TD; Jackman A; Rice FL; Kucera J; Snider WD. 2000. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo [see comments] Neuron 25(2):345-57. [PubMed: 10719890]  [MGI Ref ID J:60772]

Phillips HS; Nishimura M; Armanini MP; Chen K; Albers KM; Davis BM. 2004. Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance. Brain Res Mol Brain Res 124(1):1-11. [PubMed: 15093680]  [MGI Ref ID J:90594]

Rice FL; Albers KM; Davis BM; Silos-Santiago I; Wilkinson GA; LeMaster AM; Ernfors P; Smeyne RJ; Aldskogius H; Phillips HS; Barbacid M; DeChiara TM; Yancopoulos GD; Dunne CE; Fundin BT. 1998. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol 198(1):57-81. [PubMed: 9640332]  [MGI Ref ID J:107715]

Sedy J; Szeder V; Walro JM; Ren ZG; Nanka O; Tessarollo L; Sieber-Blum M; Grim M; Kucera J. 2004. Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn 231(3):551-63. [PubMed: 15376326]  [MGI Ref ID J:93853]

Siao CJ; Lorentz CU; Kermani P; Marinic T; Carter J; McGrath K; Padow VA; Mark W; Falcone DJ; Cohen-Gould L; Parrish DC; Habecker BA; Nykjaer A; Ellenson LH; Tessarollo L; Hempstead BL. 2012. ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med 209(12):2291-305. [PubMed: 23091165]  [MGI Ref ID J:190893]

Suo D; Park J; Harrington AW; Zweifel LS; Mihalas S; Deppmann CD. 2014. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci 17(1):36-45. [PubMed: 24270184]  [MGI Ref ID J:207835]

White FA; Silos-Santiago I; Molliver DC; Nishimura M; Phillips H; Barbacid M; Snider WD. 1996. Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. J Neurosci 16(15):4662-72. [PubMed: 8764654]  [MGI Ref ID J:34321]

Wickramasinghe SR; Alvania RS; Ramanan N; Wood JN; Mandai K; Ginty DD. 2008. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 58(4):532-45. [PubMed: 18498735]  [MGI Ref ID J:145293]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & Husbandry3/31/00: per Debbie Mayo: B6 x +/- or +/- x B6 The investigator maintains the strain by backcrossing heterozygotes to C57BL/6. Homozygotes die by 4 weeks of age.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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