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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names 129-Tg(Prm-cre)58Og/J (Changed: 25-MAR-10 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N?F?+N2F21 (24-MAR-11)
Generation DefinitionsDonating Investigator Dr. Stephen O'Gorman, Case Western Reserve University Description
Mice homozygous for this PrmCre transgene are viable and fertile. Embryonic stem cells containing recombinase transgenes that are expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, substantially simplify the production of subtle or conditional mutations in mice. This strain shows that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a cre target transgene in the male germ line, but not in other tissues. This system can be used for reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The PrmCre transgene was designed with the mouse protamine 1 promoter upstream of a modified Cre recombinase coding sequence (modified to contain a consensus translation start site, 11 codons for a human c-myc epitope, 7 codons for a minimal simian virus 40 nuclear localization signal, and a polyadenylation signal). This transgene was microinjected into pronuclei of fertilized 129/SvJae oocytes, and the resulting transgenic offspring were bred to 129/SvJae mice. Founder line 58 mice (with a single copy of the transgene) were backcrossed to 129Sv/Jae for many generations prior to arrival at The Jackson Laboratory. Upon arrival, mice were bred with 129S1/SvImJ (Stock No. 002448) for approximately two generations to establish the colony.
Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Prm-cre)58Og allele
007252 B6Ei.129S4-Tg(Prm-cre)58Og/EiJ View Strains carrying Tg(Prm-cre)58Og (1 strain)
Additional Web Information
Introduction to Cre-lox technology
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
New 129 Nomenclature Bulletin
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Prm-cre)58Og | ||
|---|---|---|---|
| Allele Name | transgene insertion 58, Stephen O'Gorman | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Prm-cre; Prm1cre; PrmCre; TgNPro:Cre; | ||
| Strain of Origin | 129S4/SvJae | ||
| Site of Expression | male germ line | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Prm1, protamine 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Prm-cre)58Og, transgene insertion 58, Stephen O'Gorman | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Prm-cre; Prm1cre; PrmCre; | ||
| Driver Note | Prm1 | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse protamine (Prm1) promoter. The transgene directs expression of Cre recombinase in the male germ cells and not in other tissues. [MGI Ref ID J:67932] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
O'Gorman S; Dagenais NA; Qian M; Marchuk Y. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 94(26):14602-7. [PubMed: 9405659] [MGI Ref ID J:67932]
Additional References
Tg(Prm-cre)58Og relatedAdams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757] [MGI Ref ID J:138227]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Atasoy D; Schoch S; Ho A; Nadasy KA; Liu X; Zhang W; Mukherjee K; Nosyreva ED; Fernandez-Chacon R; Missler M; Kavalali ET; Sudhof TC. 2007. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104(7):2525-30. [PubMed: 17287346] [MGI Ref ID J:117978]
Baek WY; de Crombrugghe B; Kim JE. 2010. Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone 46(4):920-8. [PubMed: 20026264] [MGI Ref ID J:162059]
Bark C; Bellinger FP; Kaushal A; Mathews JR; Partridge LD; Wilson MC. 2004. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci 24(40):8796-805. [PubMed: 15470145] [MGI Ref ID J:94005]
Batista F; Lu L; Williams SA; Stanley P. 2012. Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis. Biol Reprod 86(6):179. [PubMed: 22492969] [MGI Ref ID J:185823]
Bharti K; Gasper M; Ou J; Brucato M; Clore-Gronenborn K; Pickel J; Amheiter H. 2012. A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development PLoS Genet :1-59. [MGI Ref ID J:182723]
Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. [PubMed: 20596238] [MGI Ref ID J:175338]
Brade T; Kumar S; Cunningham TJ; Chatzi C; Zhao X; Cavallero S; Li P; Sucov HM; Ruiz-Lozano P; Duester G. 2011. Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development 138(1):139-48. [PubMed: 21138976] [MGI Ref ID J:167039]
Brenner S; Drewel D; Steinbart T; Weisel F; Hartel E; Potzsch S; Welzel H; Brandl A; Yu P; Mudde GC; Schweizer A; Nitschke L; Winkler TH. 2011. A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO J 30(13):2705-18. [PubMed: 21623346] [MGI Ref ID J:174233]
Cai CL; Zhou W; Yang L; Bu L; Qyang Y; Zhang X; Li X; Rosenfeld MG; Chen J; Evans S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132(10):2475-87. [PubMed: 15843407] [MGI Ref ID J:98516]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
Chandra S; Fornai F; Kwon HB; Yazdani U; Atasoy D; Liu X; Hammer RE; Battaglia G; German DC; Castillo PE; Sudhof TC. 2004. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101(41):14966-71. [PubMed: 15465911] [MGI Ref ID J:93544]
Chang YF; Lee-Chang JS; Harris KY; Sinha-Hikim AP; Rao MK. 2011. Role of beta-catenin in post-meiotic male germ cell differentiation. PLoS One 6(11):e28039. [PubMed: 22125654] [MGI Ref ID J:180951]
Chang YF; Lee-Chang JS; Imam JS; Buddavarapu KC; Subaran SS; Sinha-Hikim AP; Gorospe M; Rao MK. 2012. Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proc Natl Acad Sci U S A 109(15):5750-5. [PubMed: 22447776] [MGI Ref ID J:183553]
Chau BN; Borges HL; Chen TT; Masselli A; Hunton IC; Wang JY. 2002. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol 4(10):757-65. [PubMed: 12360286] [MGI Ref ID J:80087]
Chen JW; Zhou B; Yu QC; Shin SJ; Jiao K; Schneider MD; Baldwin HS; Bergelson JM. 2006. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res 98(7):923-30. [PubMed: 16543498] [MGI Ref ID J:121400]
Cheng A; Arumugam TV; Liu D; Khatri RG; Mustafa K; Kwak S; Ling HP; Gonzales C; Xin O; Jo DG; Guo Z; Mark RJ; Mattson MP. 2007. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci 27(7):1519-28. [PubMed: 17301160] [MGI Ref ID J:118333]
Cheng H; Zheng M; Peter AK; Kimura K; Li X; Ouyang K; Shen T; Cui L; Frank D; Dalton ND; Gu Y; Frey N; Peterson KL; Evans SM; Knowlton KU; Sheikh F; Chen J. 2011. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet 20(9):1751-62. [PubMed: 21303826] [MGI Ref ID J:170494]
Crone SA; Quinlan KA; Zagoraiou L; Droho S; Restrepo CE; Lundfald L; Endo T; Setlak J; Jessell TM; Kiehn O; Sharma K. 2008. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60(1):70-83. [PubMed: 18940589] [MGI Ref ID J:145621]
Crone SA; Viemari JC; Droho S; Mrejeru A; Ramirez JM; Sharma K. 2012. Irregular Breathing in Mice following Genetic Ablation of V2a Neurons. J Neurosci 32(23):7895-906. [PubMed: 22674265] [MGI Ref ID J:185186]
Debbache J; Zaidi MR; Davis S; Guo T; Bismuth K; Wang X; Skuntz S; Maric D; Pickel J; Meltzer P; Merlino G; Arnheiter H. 2012. In vivo Role of Alternative Splicing and Serine Phosphorylation of the Microphthalmia-associated Transcription Factor MITF. Genetics :. [PubMed: 22367038] [MGI Ref ID J:182722]
Debruyne JP; Noton E; Lambert CM; Maywood ES; Weaver DR; Reppert SM. 2006. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50(3):465-77. [PubMed: 16675400] [MGI Ref ID J:109634]
Dendouga N; Gao H; Moechars D; Janicot M; Vialard J; McGowan CH. 2005. Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol 25(17):7569-79. [PubMed: 16107704] [MGI Ref ID J:100407]
Dickendesher TL; Baldwin KT; Mironova YA; Koriyama Y; Raiker SJ; Askew KL; Wood A; Geoffroy CG; Zheng B; Liepmann CD; Katagiri Y; Benowitz LI; Geller HM; Giger RJ. 2012. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci 15(5):703-12. [PubMed: 22406547] [MGI Ref ID J:191258]
Dominguez D; Tournoy J; Hartmann D; Huth T; Cryns K; Deforce S; Serneels L; Camacho IE; Marjaux E; Craessaerts K; Roebroek AJ; Schwake M; D'Hooge R; Bach P; Kalinke U; Moechars D; Alzheimer C; Reiss K; Saftig P; De Strooper B. 2005. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35):30797-806. [PubMed: 15987683] [MGI Ref ID J:100925]
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Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. [PubMed: 20206616] [MGI Ref ID J:160493]
Fernandes HB; Catches JS; Petralia RS; Copits BA; Xu J; Russell TA; Swanson GT; Contractor A. 2009. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 63(6):818-29. [PubMed: 19778510] [MGI Ref ID J:155003]
Francis SM; Bergsied J; Isaac CE; Coschi CH; Martens AL; Hojilla CV; Chakrabarti S; Dimattia GE; Khoka R; Wang JY; Dick FA. 2009. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol 29(16):4455-66. [PubMed: 19506017] [MGI Ref ID J:151417]
Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678] [MGI Ref ID J:134633]
Gao Z; Huang Z; Olivey HE; Gurbuxani S; Crispino JD; Svensson EC. 2010. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 29(2):457-68. [PubMed: 20010697] [MGI Ref ID J:156475]
Garcia-Galiano D; van Ingen Schenau D; Leon S; Krajnc-Franken MA; Manfredi-Lozano M; Romero-Ruiz A; Navarro VM; Gaytan F; van Noort PI; Pinilla L; Blomenrohr M; Tena-Sempere M. 2012. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 153(1):316-28. [PubMed: 22067321] [MGI Ref ID J:181650]
Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719] [MGI Ref ID J:112394]
Guan X; Shi X; Li X; Chang B; Wang Y; Li D; Chan L. 2012. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab 303(7):E853-64. [PubMed: 22829581] [MGI Ref ID J:189593]
Harada K; Truong AB; Cai T; Khavari PA. 2005. The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol 25(24):11122-30. [PubMed: 16314532] [MGI Ref ID J:103754]
Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241] [MGI Ref ID J:149005]
Hellsten E; Evans JP; Bernard DJ; Janne PA; Nussbaum RL. 2001. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol 240(2):641-53. [PubMed: 11784089] [MGI Ref ID J:73678]
Hodges CA; Cotton CU; Palmert MR; Drumm ML. 2008. Generation of a conditional null allele for Cftr in mice. Genesis 46(10):546-52. [PubMed: 18802965] [MGI Ref ID J:142723]
Howng SY; Avila RL; Emery B; Traka M; Lin W; Watkins T; Cook S; Bronson R; Davisson M; Barres BA; Popko B. 2010. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev 24(3):301-11. [PubMed: 20080941] [MGI Ref ID J:156938]
Hu X; Atzler D; Xu X; Zhang P; Guo H; Lu Z; Fassett J; Schwedhelm E; Boger RH; Bache RJ; Chen Y. 2011. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol 31(7):1540-6. [PubMed: 21493890] [MGI Ref ID J:182373]
Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599] [MGI Ref ID J:135241]
Johansson JU; Ericsson J; Janson J; Beraki S; Stanic D; Mandic SA; Wikstrom MA; Hokfelt T; Ogren SO; Rozell B; Berggren PO; Bark C. 2008. An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet 4(11):e1000278. [PubMed: 19043548] [MGI Ref ID J:142096]
Jonassen JA; San Agustin J; Follit JA; Pazour GJ. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-84. [PubMed: 18981227] [MGI Ref ID J:141071]
Jones-Mason ME; Zhao X; Kappes D; Lasorella A; Iavarone A; Zhuang Y. 2012. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348-61. [PubMed: 22425249] [MGI Ref ID J:187334]
Kaeser PS; Deng L; Chavez AE; Liu X; Castillo PE; Sudhof TC. 2009. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 64(2):227-39. [PubMed: 19874790] [MGI Ref ID J:155764]
Kaeser PS; Kwon HB; Chiu CQ; Deng L; Castillo PE; Sudhof TC. 2008. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28(50):13435-47. [PubMed: 19074017] [MGI Ref ID J:143053]
Karamitros D; Kotantaki P; Lygerou Z; Veiga-Fernandes H; Pachnis V; Kioussis D; Taraviras S. 2010. Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol 184(5):2432-41. [PubMed: 20107189] [MGI Ref ID J:159657]
Kim IS; Lee M; Park KC; Jeon Y; Park JH; Hwang EJ; Jeon TI; Ko S; Lee H; Baek SH; Kim KI. 2012. Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell 46(3):260-73. [PubMed: 22516971] [MGI Ref ID J:188023]
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Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Kimura H; Kwan KM; Zhang Z; Deng JM; Darnay BG; Behringer RR; Nakamura T; de Crombrugghe B; Akiyama H. 2008. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS ONE 3(9):e3174. [PubMed: 18779865] [MGI Ref ID J:143940]
Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746] [MGI Ref ID J:130252]
Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. [PubMed: 15662031] [MGI Ref ID J:98828]
Lee S; Lee DK; Dou Y; Lee J; Lee B; Kwak E; Kong YY; Lee SK; Roeder RG; Lee JW. 2006. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A 103(42):15392-7. [PubMed: 17021013] [MGI Ref ID J:116064]
Leland S; Nagarajan P; Polyzos A; Thomas S; Samaan G; Donnell R; Marchetti F; Venkatachalam S. 2009. Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proc Natl Acad Sci U S A 106(31):12776-81. [PubMed: 19617567] [MGI Ref ID J:151880]
Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. [PubMed: 19479052] [MGI Ref ID J:149315]
Li H; Wang Z; Wang B; Guo Q; Dolios G; Tabuchi K; Hammer RE; Sudhof TC; Wang R; Zheng H. 2010. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem 285(40):30598-605. [PubMed: 20693289] [MGI Ref ID J:166379]
Li X; Zima AV; Sheikh F; Blatter LA; Chen J. 2005. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res 96(12):1274-81. [PubMed: 15933266] [MGI Ref ID J:110271]
Li Z; Cai X; Cai CL; Wang J; Zhang W; Petersen BE; Yang FC; Xu M. 2011. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118(17):4509-18. [PubMed: 21803851] [MGI Ref ID J:178415]
Liang X; Sun Y; Ye M; Scimia MC; Cheng H; Martin J; Wang G; Rearden A; Wu C; Peterson KL; Powell HC; Evans SM; Chen J. 2009. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation 120(7):568-76. [PubMed: 19652092] [MGI Ref ID J:167114]
Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. [PubMed: 15798193] [MGI Ref ID J:97635]
Ling H; Zhang T; Pereira L; Means CK; Cheng H; Gu Y; Dalton ND; Peterson KL; Chen J; Bers D; Heller Brown J. 2009. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest 119(5):1230-40. [PubMed: 19381018] [MGI Ref ID J:149675]
Liodis P; Denaxa M; Grigoriou M; Akufo-Addo C; Yanagawa Y; Pachnis V. 2007. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078-89. [PubMed: 17376969] [MGI Ref ID J:119476]
Lou Y; Javed A; Hussain S; Colby J; Frederick D; Pratap J; Xie R; Gaur T; van Wijnen AJ; Jones SN; Stein GS; Lian JB; Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18(3):556-68. [PubMed: 19028669] [MGI Ref ID J:143532]
Lozovatsky L; Abayasekara N; Piawah S; Walther Z. 2009. CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell 20(21):4489-99. [PubMed: 19726564] [MGI Ref ID J:164479]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
Marchlik E; Thakker P; Carlson T; Jiang Z; Ryan M; Marusic S; Goutagny N; Kuang W; Askew GR; Roberts V; Benoit S; Zhou T; Ling V; Pfeifer R; Stedman N; Fitzgerald KA; Lin LL; Hall JP. 2010. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol 88(6):1171-80. [PubMed: 20651301] [MGI Ref ID J:166476]
Mark MD; Maejima T; Kuckelsberg D; Yoo JW; Hyde RA; Shah V; Gutierrez D; Moreno RL; Kruse W; Noebels JL; Herlitze S. 2011. Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26. [PubMed: 21411672] [MGI Ref ID J:170451]
Masubuchi S; Gao T; O'Neill A; Eckel-Mahan K; Newton AC; Sassone-Corsi P. 2010. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A :. [PubMed: 20080691] [MGI Ref ID J:156530]
Morabito MV; Abbas AI; Hood JL; Kesterson RA; Jacobs MM; Kump DS; Hachey DL; Roth BL; Emeson RB. 2010. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol Dis 39(2):169-80. [PubMed: 20394819] [MGI Ref ID J:163043]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred. Expected coat color from breeding is White Bellied Agouti. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(Prm-cre)58Og
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(Prm-cre)58Og
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.