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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation N?F?+N2F18 (24-DEC-08) Donating Investigator Stephen O'Gorman, Case Western Reserve University Description
Mice homozygous for this PrmCre transgene are viable and fertile. Embryonic stem cells containing recombinase transgenes that are expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, substantially simplify the production of subtle or conditional mutations in mice. This strain shows that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a cre target transgene in the male germ line, but not in other tissues. This system can be used for reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.Development
The PrmCre transgene was designed with the mouse protamine 1 promoter upstream of a modified Cre recombinase coding sequence (modified to contain a consensus translation start site, 11 codons for a human c-myc epitope, 7 codons for a minimal simian virus 40 nuclear localization signal, and a polyadenylation signal). This transgene was microinjected into pronuclei of fertilized 129/SvJae oocytes, and the resulting transgenic offspring were bred to 129/SvJae mice. Founder line 58 mice (with a single copy of the transgene) were backcrossed to 129Sv/Jae for many generations prior to arrival at The Jackson Laboratory. Upon arrival, mice were bred with 129S1/SvImJ (Stock No. 002448) for approximately two generations to establish the colony.
Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Prm-cre)58Og allele
007252 B6Ei.129S4-Tg(Prm-cre)58Og/EiJ View Strains carrying Tg(Prm-cre)58Og (1 strain)
Additional Web Information
Cre-lox Systems
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
New 129 Nomenclature Bulletin
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System (Cre-Recombinase Expression: Germline/Embryonic Expression)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Research Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Prm-cre)58Og | ||
|---|---|---|---|
| Allele Name | transgene insertion 58, Stephen O'Gorman | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Prm-cre; Prm1cre; PrmCre; | ||
| Strain of Origin | 129S4/SvJae | ||
| Site of Expression | male germ line | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Prm1, protamine 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Prm-cre)58Og, transgene insertion 58, Stephen O'Gorman | ||
| Chromosome | UN | ||
| Gene Common Name(s) | PrmCre; | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse protamine (Prm1) promoter. The transgene directs expression of Cre recombinase in the male germ cells and not in other tissues. [MGI Ref ID J:117978] [MGI Ref ID J:67932] [MGI Ref ID J:98828] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
O'Gorman S; Dagenais NA; Qian M; Marchuk Y. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 94(26):14602-7. [PubMed: 9405659] [MGI Ref ID J:67932]
O'Gorman S; Sidman RL. 1985. Degeneration of thalamic neurons in Purkinje cell degeneration mutant mice. I. Distribution of neuron loss. J Comp Neurol 234(3):277-97. [PubMed: 3988985] [MGI Ref ID J:7819]
Additional References
Tg(Prm-cre)58Og relatedAdams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757] [MGI Ref ID J:138227]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Atasoy D; Schoch S; Ho A; Nadasy KA; Liu X; Zhang W; Mukherjee K; Nosyreva ED; Fernandez-Chacon R; Missler M; Kavalali ET; Sudhof TC. 2007. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104(7):2525-30. [PubMed: 17287346] [MGI Ref ID J:117978]
Bark C; Bellinger FP; Kaushal A; Mathews JR; Partridge LD; Wilson MC. 2004. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci 24(40):8796-805. [PubMed: 15470145] [MGI Ref ID J:94005]
Cai CL; Zhou W; Yang L; Bu L; Qyang Y; Zhang X; Li X; Rosenfeld MG; Chen J; Evans S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132(10):2475-87. [PubMed: 15843407] [MGI Ref ID J:98516]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
Chandra S; Fornai F; Kwon HB; Yazdani U; Atasoy D; Liu X; Hammer RE; Battaglia G; German DC; Castillo PE; Sudhof TC. 2004. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101(41):14966-71. [PubMed: 15465911] [MGI Ref ID J:93544]
Chau BN; Borges HL; Chen TT; Masselli A; Hunton IC; Wang JY. 2002. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol 4(10):757-65. [PubMed: 12360286] [MGI Ref ID J:80087]
Chen JW; Zhou B; Yu QC; Shin SJ; Jiao K; Schneider MD; Baldwin HS; Bergelson JM. 2006. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res 98(7):923-30. [PubMed: 16543498] [MGI Ref ID J:121400]
Cheng A; Arumugam TV; Liu D; Khatri RG; Mustafa K; Kwak S; Ling HP; Gonzales C; Xin O; Jo DG; Guo Z; Mark RJ; Mattson MP. 2007. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci 27(7):1519-28. [PubMed: 17301160] [MGI Ref ID J:118333]
Crone SA; Quinlan KA; Zagoraiou L; Droho S; Restrepo CE; Lundfald L; Endo T; Setlak J; Jessell TM; Kiehn O; Sharma K. 2008. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60(1):70-83. [PubMed: 18940589] [MGI Ref ID J:145621]
Debruyne JP; Noton E; Lambert CM; Maywood ES; Weaver DR; Reppert SM. 2006. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50(3):465-77. [PubMed: 16675400] [MGI Ref ID J:109634]
Dendouga N; Gao H; Moechars D; Janicot M; Vialard J; McGowan CH. 2005. Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol 25(17):7569-79. [PubMed: 16107704] [MGI Ref ID J:100407]
Dominguez D; Tournoy J; Hartmann D; Huth T; Cryns K; Deforce S; Serneels L; Camacho IE; Marjaux E; Craessaerts K; Roebroek AJ; Schwake M; D'Hooge R; Bach P; Kalinke U; Moechars D; Alzheimer C; Reiss K; Saftig P; De Strooper B. 2005. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35):30797-806. [PubMed: 15987683] [MGI Ref ID J:100925]
Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. [PubMed: 18543318] [MGI Ref ID J:137217]
Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678] [MGI Ref ID J:134633]
Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719] [MGI Ref ID J:112394]
Harada K; Truong AB; Cai T; Khavari PA. 2005. The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol 25(24):11122-30. [PubMed: 16314532] [MGI Ref ID J:103754]
Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241] [MGI Ref ID J:149005]
Hellsten E; Evans JP; Bernard DJ; Janne PA; Nussbaum RL. 2001. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol 240(2):641-53. [PubMed: 11784089] [MGI Ref ID J:73678]
Hodges CA; Cotton CU; Palmert MR; Drumm ML. 2008. Generation of a conditional null allele for Cftr in mice. Genesis 46(10):546-52. [PubMed: 18802965] [MGI Ref ID J:142723]
Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599] [MGI Ref ID J:135241]
Johansson JU; Ericsson J; Janson J; Beraki S; Stanic D; Mandic SA; Wikstrom MA; Hokfelt T; Ogren SO; Rozell B; Berggren PO; Bark C. 2008. An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet 4(11):e1000278. [PubMed: 19043548] [MGI Ref ID J:142096]
Jonassen JA; San Agustin J; Follit JA; Pazour GJ. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-84. [PubMed: 18981227] [MGI Ref ID J:141071]
Kaeser PS; Kwon HB; Chiu CQ; Deng L; Castillo PE; Sudhof TC. 2008. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28(50):13435-47. [PubMed: 19074017] [MGI Ref ID J:143053]
Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Kimura H; Kwan KM; Zhang Z; Deng JM; Darnay BG; Behringer RR; Nakamura T; de Crombrugghe B; Akiyama H. 2008. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS ONE 3(9):e3174. [PubMed: 18779865] [MGI Ref ID J:143940]
Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746] [MGI Ref ID J:130252]
Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. [PubMed: 15662031] [MGI Ref ID J:98828]
Lee S; Lee DK; Dou Y; Lee J; Lee B; Kwak E; Kong YY; Lee SK; Roeder RG; Lee JW. 2006. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A 103(42):15392-7. [PubMed: 17021013] [MGI Ref ID J:116064]
Li X; Zima AV; Sheikh F; Blatter LA; Chen J. 2005. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res 96(12):1274-81. [PubMed: 15933266] [MGI Ref ID J:110271]
Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. [PubMed: 15798193] [MGI Ref ID J:97635]
Liodis P; Denaxa M; Grigoriou M; Akufo-Addo C; Yanagawa Y; Pachnis V. 2007. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078-89. [PubMed: 17376969] [MGI Ref ID J:119476]
Lou Y; Javed A; Hussain S; Colby J; Frederick D; Pratap J; Xie R; Gaur T; van Wijnen AJ; Jones SN; Stein GS; Lian JB; Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18(3):556-68. [PubMed: 19028669] [MGI Ref ID J:143532]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
O'Donnell N; Zachara NE; Hart GW; Marth JD. 2004. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24(4):1680-90. [PubMed: 14749383] [MGI Ref ID J:93112]
Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. [PubMed: 15607980] [MGI Ref ID J:95316]
Penzo-Mendez A; Dy P; Pallavi B; Lefebvre V. 2007. Generation of mice harboring a Sox4 conditional null allele. Genesis 45(12):776-80. [PubMed: 18064674] [MGI Ref ID J:130461]
Puckelwartz MJ; Kessler E; Zhang Y; Hodzic D; Randles KN; Morris G; Earley JU; Hadhazy M; Holaska JM; Mewborn SK; Pytel P; McNally EM. 2009. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet 18(4):607-20. [PubMed: 19008300] [MGI Ref ID J:144757]
Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137] [MGI Ref ID J:134477]
Schaff UY; Shih HH; Lorenz M; Sako D; Kriz R; Milarski K; Bates B; Tchernychev B; Shaw GD; Simon SI. 2008. SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1. Eur J Immunol 38(2):550-64. [PubMed: 18196517] [MGI Ref ID J:131282]
Schoch S; Mittelstaedt T; Kaeser PS; Padgett D; Feldmann N; Chevaleyre V; Castillo PE; Hammer RE; Han W; Schmitz F; Lin W; Sudhof TC. 2006. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J 25(24):5852-63. [PubMed: 17124501] [MGI Ref ID J:119934]
Seidler B; Schmidt A; Mayr U; Nakhai H; Schmid RM; Schneider G; Saur D. 2008. A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A 105(29):10137-42. [PubMed: 18621715] [MGI Ref ID J:140423]
Seymour PA; Freude KK; Dubois CL; Shih HP; Patel NA; Sander M. 2008. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol 323(1):19-30. [PubMed: 18723011] [MGI Ref ID J:141017]
Sharma K; Leonard AE; Lettieri K; Pfaff SL. 2000. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature 406(6795):515-9. [PubMed: 10952312] [MGI Ref ID J:63774]
Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402] [MGI Ref ID J:119477]
St Amand TR; Lu JT; Zamora M; Gu Y; Stricker J; Hoshijima M; Epstein JA; Ross JJ Jr; Ruiz-Lozano P; Chien KR. 2006. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol 291(2):208-17. [PubMed: 16430881] [MGI Ref ID J:107057]
Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815] [MGI Ref ID J:136969]
Starremans PG; Li X; Finnerty PE; Guo L; Takakura A; Neilson EG; Zhou J. 2008. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int 73(12):1394-405. [PubMed: 18385665] [MGI Ref ID J:140012]
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Verhulst PJ; De Smet B; Saels I; Thijs T; Ver Donck L; Moechars D; Peeters TL; Depoortere I. 2008. Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. Gastroenterology 135(4):1267-76. [PubMed: 18657539] [MGI Ref ID J:141985]
Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486] [MGI Ref ID J:100131]
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Williams G; Wood A; Williams EJ; Gao Y; Mercado ML; Katz A; Joseph-McCarthy D; Bates B; Ling HP; Aulabaugh A; Zaccardi J; Xie Y; Pangalos MN; Walsh FS; Doherty P. 2008. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem 283(24):16641-52. [PubMed: 18411262] [MGI Ref ID J:138580]
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Yao J; Le TC; Kos CH; Henderson JM; Allen PG; Denker BM; Pollak MR. 2004. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol 2(6):787-94. [PubMed: 15208719] [MGI Ref ID J:90755]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred. Expected coat color from breeding is White Bellied Agouti. Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $107.90 Female or Male Homozygous for Tg(Prm-cre)58Og
Pairs /Price (US dollars $) Pair Genotype $215.80 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $140.30 Female or Male Homozygous for Tg(Prm-cre)58Og
Pairs /Price (US dollars $) Pair Genotype $280.60 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.