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Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation N?F?+N2F18 (24-DEC-08) Donating Investigator Stephen O'Gorman, Case Western Reserve University Description
Mice homozygous for this PrmCre transgene are viable and fertile. Embryonic stem cells containing recombinase transgenes that are expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, substantially simplify the production of subtle or conditional mutations in mice. This strain shows that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a cre target transgene in the male germ line, but not in other tissues. This system can be used for reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.Development
The PrmCre transgene was designed with the mouse protamine 1 promoter upstream of a modified Cre recombinase coding sequence (modified to contain a consensus translation start site, 11 codons for a human c-myc epitope, 7 codons for a minimal simian virus 40 nuclear localization signal, and a polyadenylation signal). This transgene was microinjected into pronuclei of fertilized 129/SvJae oocytes, and the resulting transgenic offspring were bred to 129/SvJae mice. Founder line 58 mice (with a single copy of the transgene) were backcrossed to 129Sv/Jae for many generations prior to arrival at The Jackson Laboratory. Upon arrival, mice were bred with 129S1/SvImJ (Stock No. 002448) for approximately two generations to establish the colony.
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
Strains carrying Tg(Prm-cre)58Og allele
007252 B6Ei.129S4-Tg(Prm-cre)58Og/EiJ View Strains carrying Tg(Prm-cre)58Og (1 strain)
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (146 strains)
Cre-lox Systems
JAX® NOTES, Summer 2001; 482. Cre Transgenic Strains for Conditional Mutagenesis.
New 129 Nomenclature Bulletin
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System (Cre-Recombinase Expression: Germline/Embryonic Expression)
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
Research Tools
Cre-lox System
Genetics Research (Mutagenesis and Transgenesis: Cre-lox System)
| Allele Symbol | Tg(Prm-cre)58Og | ||
|---|---|---|---|
| Allele Name | transgene insertion 58, Stephen O'Gorman | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Prm-cre; Prm1cre; PrmCre; | ||
| Strain of Origin | 129S4/SvJae | ||
| Site of Expression | male germ line | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Prm1, protamine 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Prm-cre)58Og, transgene insertion 58, Stephen O'Gorman | ||
| Chromosome | UN | ||
| Gene Common Name(s) | PrmCre; | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse protamine (Prm1) promoter. The transgene directs expression of Cre recombinase in the male germ cells and not in other tissues. [MGI Ref ID J:117978] [MGI Ref ID J:67932] [MGI Ref ID J:98828] | ||
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR, vers. 1
Generic Cre, STD PCR, vers. 1
Helpful Links
Genotyping resources and troubleshooting
O'Gorman S; Dagenais NA; Qian M; Marchuk Y. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 94(26):14602-7. [PubMed: 9405659] [MGI Ref ID J:67932]
O'Gorman S; Sidman RL. 1985. Degeneration of thalamic neurons in Purkinje cell degeneration mutant mice. I. Distribution of neuron loss. J Comp Neurol 234(3):277-97. [PubMed: 3988985] [MGI Ref ID J:7819]
Tg(Prm-cre)58Og relatedAdams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757] [MGI Ref ID J:138227]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Atasoy D; Schoch S; Ho A; Nadasy KA; Liu X; Zhang W; Mukherjee K; Nosyreva ED; Fernandez-Chacon R; Missler M; Kavalali ET; Sudhof TC. 2007. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104(7):2525-30. [PubMed: 17287346] [MGI Ref ID J:117978]
Bark C; Bellinger FP; Kaushal A; Mathews JR; Partridge LD; Wilson MC. 2004. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci 24(40):8796-805. [PubMed: 15470145] [MGI Ref ID J:94005]
Cai CL; Zhou W; Yang L; Bu L; Qyang Y; Zhang X; Li X; Rosenfeld MG; Chen J; Evans S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132(10):2475-87. [PubMed: 15843407] [MGI Ref ID J:98516]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
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Kaeser PS; Kwon HB; Chiu CQ; Deng L; Castillo PE; Sudhof TC. 2008. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28(50):13435-47. [PubMed: 19074017] [MGI Ref ID J:143053]
Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Kimura H; Kwan KM; Zhang Z; Deng JM; Darnay BG; Behringer RR; Nakamura T; de Crombrugghe B; Akiyama H. 2008. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS ONE 3(9):e3174. [PubMed: 18779865] [MGI Ref ID J:143940]
Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746] [MGI Ref ID J:130252]
Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. [PubMed: 15662031] [MGI Ref ID J:98828]
Lee S; Lee DK; Dou Y; Lee J; Lee B; Kwak E; Kong YY; Lee SK; Roeder RG; Lee JW. 2006. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A 103(42):15392-7. [PubMed: 17021013] [MGI Ref ID J:116064]
Li X; Zima AV; Sheikh F; Blatter LA; Chen J. 2005. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res 96(12):1274-81. [PubMed: 15933266] [MGI Ref ID J:110271]
Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. [PubMed: 15798193] [MGI Ref ID J:97635]
Liodis P; Denaxa M; Grigoriou M; Akufo-Addo C; Yanagawa Y; Pachnis V. 2007. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078-89. [PubMed: 17376969] [MGI Ref ID J:119476]
Lou Y; Javed A; Hussain S; Colby J; Frederick D; Pratap J; Xie R; Gaur T; van Wijnen AJ; Jones SN; Stein GS; Lian JB; Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18(3):556-68. [PubMed: 19028669] [MGI Ref ID J:143532]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
O'Donnell N; Zachara NE; Hart GW; Marth JD. 2004. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24(4):1680-90. [PubMed: 14749383] [MGI Ref ID J:93112]
Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. [PubMed: 15607980] [MGI Ref ID J:95316]
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Puckelwartz MJ; Kessler E; Zhang Y; Hodzic D; Randles KN; Morris G; Earley JU; Hadhazy M; Holaska JM; Mewborn SK; Pytel P; McNally EM. 2009. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet 18(4):607-20. [PubMed: 19008300] [MGI Ref ID J:144757]
Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137] [MGI Ref ID J:134477]
Schaff UY; Shih HH; Lorenz M; Sako D; Kriz R; Milarski K; Bates B; Tchernychev B; Shaw GD; Simon SI. 2008. SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1. Eur J Immunol 38(2):550-64. [PubMed: 18196517] [MGI Ref ID J:131282]
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Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred. Expected coat color from breeding is White Bellied Agouti. Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $107.90 Female or Male Homozygous for Tg(Prm-cre)58Og
Pairs /Price (US dollars $) Pair Genotype $215.80 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $140.30 Female or Male Homozygous for Tg(Prm-cre)58Og
Pairs /Price (US dollars $) Pair Genotype $280.60 Homozygous for Tg(Prm-cre)58Og x Homozygous for Tg(Prm-cre)58Og
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.