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The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names FVB/N-TgN(ACTB-Cre)2Mrt    (Changed: 15-DEC-04 )
Type Transgenic;
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Specieslaboratory mouse
Donating InvestigatorDr. Gail Martin,   University of California San Francisco

This transgenic strain expresses Cre recombinase under the control of the human beta actin gene promoter. Cre recombinase activity is detected in all cells of the embryo by the blastocyst stage of development. It is useful as a "deletor" mouse for virtually any genomic sequence flanked by loxP sites. Homozygotes are viable and fertile.

A transgenic insert designed by Drs. Mark Lewandoski and Gail R. Martin (University of California, San Francisco) containing Cre recombinase under the control of the human beta-actin promoter was injected into fertilized FVB/N mouse eggs. Founder line 2 was subsequently established. The mice were maintained on the FVB/N background.

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(ACTB-cre)2Mrt allele
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
View Strains carrying   Tg(ACTB-cre)2Mrt     (1 strain)

View Strains carrying other alleles of ACTB     (13 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(ACTB-cre)2Mrt
Allele Name transgene insertion 2, Gail R Martin
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) A-cre; Act-Cre; TgN(ACTB-cre)2Mrt; actin-cre; beta-actin-Cre; beta-actin::Cre; beta-actin:Cre; creactin;
Mutation Made ByDr. Gail Martin,   University of California San Francisco
Strain of OriginFVB/N
Site of Expressionall cells of the embryo by the blastocyst stage of development; widespread expression
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter ACTB, actin, beta, human
Driver Note ACTB
Molecular Note This transgene expresses Cre recombinase under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. [MGI Ref ID J:46833]


Genotyping Information

Genotyping Protocols

Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Lewandoski M; Meyers EN; Martin GR. 1997. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb Symp Quant Biol 62:159-68. [PubMed: 9598348]  [MGI Ref ID J:46833]

Additional References

Moqrich A; Earley TJ; Watson J; Andahazy M; Backus C; Martin-Zanca D; Wright DE; Reichardt LF; Patapoutian A. 2004. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci 7(8):812-8. [PubMed: 15247919]  [MGI Ref ID J:92099]

Tg(ACTB-cre)2Mrt related

Abdulkadir SA; Magee JA; Peters TJ; Kaleem Z; Naughton CK; Humphrey PA; Milbrandt J. 2002. Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22(5):1495-503. [PubMed: 11839815]  [MGI Ref ID J:74350]

Agrawal P; Wang M; Kim S; Lewis AE; Bush JO. 2014. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn 243(11):1470-6. [PubMed: 25073978]  [MGI Ref ID J:216216]

Akbay EA; Moslehi J; Christensen CL; Saha S; Tchaicha JH; Ramkissoon SH; Stewart KM; Carretero J; Kikuchi E; Zhang H; Cohoon TJ; Murray S; Liu W; Uno K; Fisch S; Jones K; Gurumurthy S; Gliser C; Choe S; Keenan M; Son J; Stanley I; Losman JA; Padera R; Bronson RT; Asara JM; Abdel-Wahab O; Amrein PC; Fathi AT; Danial NN; Kimmelman AC; Kung AL; Ligon KL; Yen KE; Kaelin WG Jr; Bardeesy N; Wong KK. 2014. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev 28(5):479-90. [PubMed: 24589777]  [MGI Ref ID J:209629]

Ali SR; Hippenmeyer S; Saadat LV; Luo L; Weissman IL; Ardehali R. 2014. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A 111(24):8850-5. [PubMed: 24876275]  [MGI Ref ID J:211645]

Altuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 23(4):444-53. [PubMed: 19164450]  [MGI Ref ID J:146896]

Amable L; Grankvist N; Largen JW; Ortsater H; Sjoholm A; Honkanen RE. 2011. Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1). J Biol Chem 286(47):40413-22. [PubMed: 21921034]  [MGI Ref ID J:178164]

Andoniadou CL; Signore M; Sajedi E; Gaston-Massuet C; Kelberman D; Burns AJ; Itasaki N; Dattani M; Martinez-Barbera JP. 2007. Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development 134(8):1499-508. [PubMed: 17360769]  [MGI Ref ID J:135132]

Arnold JS; Werling U; Braunstein EM; Liao J; Nowotschin S; Edelmann W; Hebert JM; Morrow BE. 2006. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133(5):977-87. [PubMed: 16452092]  [MGI Ref ID J:105980]

Asai N; Fukuda T; Wu Z; Enomoto A; Pachnis V; Takahashi M; Costantini F. 2006. Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133(22):4507-16. [PubMed: 17050626]  [MGI Ref ID J:116089]

Awatramani R; Soriano P; Rodriguez C; Mai JJ; Dymecki SM. 2003. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35(1):70-5. [PubMed: 12923530]  [MGI Ref ID J:128980]

Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616]  [MGI Ref ID J:130978]

Baba M; Keller JR; Sun HW; Resch W; Kuchen S; Suh HC; Hasumi H; Hasumi Y; Kieffer-Kwon KR; Gonzalez CG; Hughes RM; Klein ME; Oh HF; Bible P; Southon E; Tessarollo L; Schmidt LS; Linehan WM; Casellas R. 2012. The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development. Blood 120(6):1254-61. [PubMed: 22709692]  [MGI Ref ID J:189078]

Balciuniene J; Bardwell VJ; Zarkower D. 2006. Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles. Mol Cell Biol 26(23):8984-91. [PubMed: 16982677]  [MGI Ref ID J:118110]

Basson MA; Akbulut S; Watson-Johnson J; Simon R; Carroll TJ; Shakya R; Gross I; Martin GR; Lufkin T; McMahon AP; Wilson PD; Costantini FD; Mason IJ; Licht JD. 2005. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 8(2):229-39. [PubMed: 15691764]  [MGI Ref ID J:96485]

Bisgrove BW; Makova S; Yost HJ; Brueckner M. 2012. RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol 363(1):166-78. [PubMed: 22233545]  [MGI Ref ID J:182770]

Biswas K; Das R; Eggington JM; Qiao H; North SL; Stauffer S; Burkett SS; Martin BK; Southon E; Sizemore SC; Pruss D; Bowles KR; Roa BB; Hunter N; Tessarollo L; Wenstrup RJ; Byrd RA; Sharan SK. 2012. Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet 21(18):3993-4006. [PubMed: 22678057]  [MGI Ref ID J:187434]

Bloom AJ; Miller BR; Sanes JR; Diantonio A. 2007. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev 21(20):2593-606. [PubMed: 17901218]  [MGI Ref ID J:125702]

Brantley MA Jr; Jain S; Barr EE; Johnson EM Jr; Milbrandt J. 2008. Neurturin-mediated ret activation is required for retinal function. J Neurosci 28(16):4123-35. [PubMed: 18417692]  [MGI Ref ID J:134527]

Brown D; Yu BD; Joza N; Benit P; Meneses J; Firpo M; Rustin P; Penninger JM; Martin GR. 2006. Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A 103(26):9918-23. [PubMed: 16788063]  [MGI Ref ID J:111066]

Buckley DM; Burroughs-Garcia J; Lewandoski M; Waters ST. 2013. Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. PLoS One 8(2):e56214. [PubMed: 23418536]  [MGI Ref ID J:197199]

Buffelli M; Burgess RW; Feng G; Lobe CG; Lichtman JW; Sanes JR. 2003. Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature 424(6947):430-4. [PubMed: 12879071]  [MGI Ref ID J:89596]

Buttermore ED; Dupree JL; Cheng J; An X; Tessarollo L; Bhat MA. 2011. The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci 31(22):8013-8024. [PubMed: 21632923]  [MGI Ref ID J:173383]

Buttermore ED; Piochon C; Wallace ML; Philpot BD; Hansel C; Bhat MA. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci 32(14):4724-42. [PubMed: 22492029]  [MGI Ref ID J:184009]

Callis TE; Pandya K; Seok HY; Tang RH; Tatsuguchi M; Huang ZP; Chen JF; Deng Z; Gunn B; Shumate J; Willis MS; Selzman CH; Wang DZ. 2009. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 119(9):2772-86. [PubMed: 19726871]  [MGI Ref ID J:152696]

Campbell S; Burkly LC; Gao HX; Berman JW; Su L; Browning B; Zheng T; Schiffer L; Michaelson JS; Putterman C. 2006. Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol 176(3):1889-98. [PubMed: 16424220]  [MGI Ref ID J:126416]

Chang C; Lee SO; Yeh S; Chang TM. 2014. Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver. Oncogene 33(25):3225-34. [PubMed: 23873027]  [MGI Ref ID J:212618]

Chen M; Hsu I; Wolfe A; Radovick S; Huang K; Yu S; Chang C; Messing EM; Yeh S. 2009. Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology 150(1):251-9. [PubMed: 18755802]  [MGI Ref ID J:147000]

Chen M; Wolfe A; Wang X; Chang C; Yeh S; Radovick S. 2009. Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. Mol Cell Biochem 321(1-2):145-53. [PubMed: 18953638]  [MGI Ref ID J:147191]

Chen M; Yeh CR; Chang HC; Vitkus S; Wen XQ; Bhowmick NA; Wolfe A; Yeh S. 2012. Loss of epithelial oestrogen receptor alpha inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. J Pathol 226(1):17-27. [PubMed: 22069040]  [MGI Ref ID J:180158]

Chen MH; Gao N; Kawakami T; Chuang PT. 2005. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol 25(16):7042-53. [PubMed: 16055716]  [MGI Ref ID J:131268]

Chen MH; Li YJ; Kawakami T; Xu SM; Chuang PT. 2004. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 18(6):641-59. [PubMed: 15075292]  [MGI Ref ID J:89228]

Cheng X; Hsu CM; Currle DS; Hu JS; Barkovich AJ; Monuki ES. 2006. Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci 26(29):7640-9. [PubMed: 16855091]  [MGI Ref ID J:110657]

Cheng Y; Buffone MG; Kouadio M; Goodheart M; Page DC; Gerton GL; Davidson I; Wang PJ. 2007. Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol 27(7):2582-9. [PubMed: 17242199]  [MGI Ref ID J:121371]

Chia IV; Costantini F. 2005. Mouse axin and axin2/conductin proteins are functionally equivalent in vivo. Mol Cell Biol 25(11):4371-6. [PubMed: 15899843]  [MGI Ref ID J:98893]

Chia IV; Kim MJ; Itoh K; Sokol SY; Costantini F. 2009. Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis. Genetics 181(4):1359-68. [PubMed: 19204372]  [MGI Ref ID J:147293]

Chizhikov VV; Lindgren AG; Currle DS; Rose MF; Monuki ES; Millen KJ. 2006. The roof plate regulates cerebellar cell-type specification and proliferation. Development 133(15):2793-804. [PubMed: 16790481]  [MGI Ref ID J:119033]

Christiansen JR; Kolandaivelu S; Bergo MO; Ramamurthy V. 2011. RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Natl Acad Sci U S A 108(21):8862-6. [PubMed: 21555557]  [MGI Ref ID J:171900]

Chuang KH; Altuwaijri S; Li G; Lai JJ; Chu CY; Lai KP; Lin HY; Hsu JW; Keng P; Wu MC; Chang C. 2009. Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J Exp Med 206(5):1181-99. [PubMed: 19414555]  [MGI Ref ID J:148491]

Coppola V; Barrick CA; Bobisse S; Rodriguez-Galan MC; Pivetta M; Reynolds D; Howard OM; Palko ME; Esteban PF; Young HA; Rosato A; Tessarollo L. 2006. The scaffold protein cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Mol Cell Biol 26(14):5249-58. [PubMed: 16809763]  [MGI Ref ID J:110320]

Cubelos B; Sebastian-Serrano A; Kim S; Moreno-Ortiz C; Redondo JM; Walsh CA; Nieto M. 2008. Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone. Cereb Cortex 18(8):1758-70. [PubMed: 18033766]  [MGI Ref ID J:156578]

Currle DS; Cheng X; Hsu CM; Monuki ES. 2005. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. Development 132(15):3549-59. [PubMed: 15975937]  [MGI Ref ID J:100435]

Danielian PS; Friesenhahn LB; Faust AM; West JC; Caron AM; Bronson RT; Lees JA. 2008. E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene 27(51):6561-70. [PubMed: 18663357]  [MGI Ref ID J:147270]

Diggle CP; Shires M; McRae C; Crellin D; Fisher J; Carr IM; Markham AF; Hayward BE; Asipu A; Bonthron DT. 2010. Both isoforms of ketohexokinase are dispensable for normal growth and development. Physiol Genomics 42A(4):235-43. [PubMed: 20841500]  [MGI Ref ID J:166959]

Diril MK; Ratnacaram CK; Padmakumar VC; Du T; Wasser M; Coppola V; Tessarollo L; Kaldis P. 2012. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A 109(10):3826-31. [PubMed: 22355113]  [MGI Ref ID J:182141]

Dowdle WE; Robinson JF; Kneist A; Sirerol-Piquer MS; Frints SG; Corbit KC; Zaghloul NA; van Lijnschoten G; Mulders L; Verver DE; Zerres K; Reed RR; Attie-Bitach T; Johnson CA; Garcia-Verdugo JM; Katsanis N; Bergmann C; Reiter JF. 2011. Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet 89(1):94-110. [PubMed: 21763481]  [MGI Ref ID J:178421]

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Pirity MK; Wang WL; Wolf LV; Tamm ER; Schreiber-Agus N; Cvekl A. 2007. Rybp, a polycomb complex-associated protein, is required for mouse eye development. BMC Dev Biol 7:39. [PubMed: 17470285]  [MGI Ref ID J:134428]

Pitera JE; Turmaine M; Woolf AS; Scambler PJ. 2012. Generation of mice with a conditional null fraser syndrome 1 (Fras1) allele. Genesis 50(12):892-8. [PubMed: 22730198]  [MGI Ref ID J:190659]

Platt RJ; Chen S; Zhou Y; Yim MJ; Swiech L; Kempton HR; Dahlman JE; Parnas O; Eisenhaure TM; Jovanovic M; Graham DB; Jhunjhunwala S; Heidenreich M; Xavier RJ; Langer R; Anderson DG; Hacohen N; Regev A; Feng G; Sharp PA; Zhang F. 2014. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. Cell 159(2):440-55. [PubMed: 25263330]  [MGI Ref ID J:213550]

Prasad T; Wang X; Gray PA; Weiner JA. 2008. A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development 135(24):4153-64. [PubMed: 19029045]  [MGI Ref ID J:142349]

Prasad T; Weiner JA. 2011. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the gamma-Protocadherins. Front Mol Neurosci 4:54. [PubMed: 22275881]  [MGI Ref ID J:190261]

Proctor JM; Zang K; Wang D; Wang R; Reichardt LF. 2005. Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci 25(43):9940-8. [PubMed: 16251442]  [MGI Ref ID J:102190]

Raimondi A; Ferguson SM; Lou X; Armbruster M; Paradise S; Giovedi S; Messa M; Kono N; Takasaki J; Cappello V; O'Toole E; Ryan TA; De Camilli P. 2011. Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron 70(6):1100-14. [PubMed: 21689597]  [MGI Ref ID J:175247]

Ratajczak CK; Asada M; Allen GC; McMahon DG; Muglia LM; Smith D; Bhattacharyya S; Muglia LJ. 2012. Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reprod Fertil Dev 24(5):759-67. [PubMed: 22697126]  [MGI Ref ID J:188253]

Rauch SM; Huen K; Miller MC; Chaudry H; Lau M; Sanes JR; Johanson CE; Stopa EG; Burgess RW. 2011. Changes in brain beta-amyloid deposition and aquaporin 4 levels in response to altered agrin expression in mice. J Neuropathol Exp Neurol 70(12):1124-37. [PubMed: 22082664]  [MGI Ref ID J:220073]

Rheault MN; Kren SM; Thielen BK; Mesa HA; Crosson JT; Thomas W; Sado Y; Kashtan CE; Segal Y. 2004. Mouse model of X-linked Alport syndrome. J Am Soc Nephrol 15(6):1466-74. [PubMed: 15153557]  [MGI Ref ID J:102306]

Robertson SD; Plummer NW; de Marchena J; Jensen P. 2013. Developmental origins of central norepinephrine neuron diversity. Nat Neurosci :. [PubMed: 23852112]  [MGI Ref ID J:198264]

Rodriguez CI; Cheng JG; Liu L; Stewart CL. 2004. Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Endocrinology 145(3):1410-8. [PubMed: 14657014]  [MGI Ref ID J:105566]

Rowan S; Cepko CL. 2004. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 271(2):388-402. [PubMed: 15223342]  [MGI Ref ID J:91498]

Sajedi E; Gaston-Massuet C; Signore M; Andoniadou CL; Kelberman D; Castro S; Etchevers HC; Gerrelli D; Dattani MT; Martinez-Barbera JP. 2008. Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech 1(4-5):241-54. [PubMed: 19093031]  [MGI Ref ID J:142649]

Salles-Crawley II; Monkman JH; Ahnstrom J; Lane DA; Crawley JT. 2014. Vessel wall BAMBI contributes to hemostasis and thrombus stability. Blood 123(18):2873-81. [PubMed: 24627527]  [MGI Ref ID J:210879]

Scheijen B; Bronk M; van der Meer T; Bernards R. 2003. Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol 23(10):3656-68. [PubMed: 12724423]  [MGI Ref ID J:83303]

Schmouth JF; Castellarin M; Laprise S; Banks KG; Bonaguro RJ; McInerny SC; Borretta L; Amirabbasi M; Korecki AJ; Portales-Casamar E; Wilson G; Dreolini L; Jones SJ; Wasserman WW; Goldowitz D; Holt RA; Simpson EM. 2013. Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice. BMC Biol 11:106. [PubMed: 24124870]  [MGI Ref ID J:205141]

Shapiro-Shelef M; Lin KI; McHeyzer-Williams LJ; Liao J; McHeyzer-Williams MG; Calame K. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19(4):607-20. [PubMed: 14563324]  [MGI Ref ID J:101890]

Shen J; Walsh CA. 2005. Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol 25(9):3639-47. [PubMed: 15831469]  [MGI Ref ID J:97642]

Shen S; Lau J; Zhu M; Zou J; Fuller D; Li QJ; Zhang W. 2009. The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. Blood 114(1):74-84. [PubMed: 19401562]  [MGI Ref ID J:150304]

Shen S; Zhu M; Lau J; Chuck M; Zhang W. 2009. The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol 182(9):5596-604. [PubMed: 19380807]  [MGI Ref ID J:147946]

Shibazaki S; Yu Z; Nishio S; Tian X; Thomson RB; Mitobe M; Louvi A; Velazquez H; Ishibe S; Cantley LG; Igarashi P; Somlo S. 2008. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17(11):1505-16. [PubMed: 18263604]  [MGI Ref ID J:135301]

Shim K; Minowada G; Coling DE; Martin GR. 2005. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell 8(4):553-64. [PubMed: 15809037]  [MGI Ref ID J:98303]

Siggers P; Carre GA; Bogani D; Warr N; Wells S; Hilton H; Esapa C; Hajihosseini MK; Greenfield A. 2014. A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal. PLoS One 9(6):e100447. [PubMed: 24956260]  [MGI Ref ID J:216825]

Simin K; Hill R; Song Y; Zhang Q; Bash R; Cardiff RD; Yin C; Xiao A; McCarthy K; van Dyke T. 2005. Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol 70:283-90. [PubMed: 16869764]  [MGI Ref ID J:116748]

Simrick S; Szumska D; Gardiner JR; Jones K; Sagar K; Morrow B; Bhattacharya S; Basson MA. 2012. Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling. Dev Dyn 241(8):1310-24. [PubMed: 22674535]  [MGI Ref ID J:185606]

Smith-Hicks CL; Sizer KC; Powers JF; Tischler AS; Costantini F. 2000. C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. EMBO J 19(4):612-22. [PubMed: 10675330]  [MGI Ref ID J:60659]

Song Y; Gilbert D; O'Sullivan TN; Yang C; Pan W; Fathalizadeh A; Lu L; Haines DC; Martin PL; Van Dyke T. 2013. Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues. PLoS One 8(12):e80459. [PubMed: 24312475]  [MGI Ref ID J:221017]

Srinivas S; Watanabe T; Lin CS; William CM; Tanabe Y; Jessell TM; Costantini F. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1(1):4. [PubMed: 11299042]  [MGI Ref ID J:80963]

Stafford DA; Brunet LJ; Khokha MK; Economides AN; Harland RM. 2011. Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 138(5):1005-14. [PubMed: 21303853]  [MGI Ref ID J:169133]

Stafford DA; Monica SD; Harland RM. 2014. Follistatin interacts with Noggin in the development of the axial skeleton. Mech Dev 131:78-85. [PubMed: 24514266]  [MGI Ref ID J:208423]

Stankunas K; Bayle JH; Gestwicki JE; Lin YM; Wandless TJ; Crabtree GR. 2003. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell 12(6):1615-24. [PubMed: 14690613]  [MGI Ref ID J:100153]

Steinecke A; Gampe C; Zimmer G; Rudolph J; Bolz J. 2014. EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development 141(2):460-71. [PubMed: 24381199]  [MGI Ref ID J:206575]

Sterky FH; Lee S; Wibom R; Olson L; Larsson NG. 2011. Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A 108(31):12937-42. [PubMed: 21768369]  [MGI Ref ID J:176022]

Stickens D; Behonick DJ; Ortega N; Heyer B; Hartenstein B; Yu Y; Fosang AJ; Schorpp-Kistner M; Angel P; Werb Z. 2004. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development 131(23):5883-95. [PubMed: 15539485]  [MGI Ref ID J:94460]

Stuckey DW; Di Gregorio A; Clements M; Rodriguez TA. 2011. Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One 6(3):e17620. [PubMed: 21445260]  [MGI Ref ID J:171680]

Tang N; Marshall WF; McMahon M; Metzger RJ; Martin GR. 2011. Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science 333(6040):342-5. [PubMed: 21764747]  [MGI Ref ID J:174194]

Taranova OV; Magness ST; Fagan BM; Wu Y; Surzenko N; Hutton SR; Pevny LH. 2006. SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev 20(9):1187-202. [PubMed: 16651659]  [MGI Ref ID J:108452]

Thaxton C; Pillai AM; Pribisko AL; Labasque M; Dupree JL; Faivre-Sarrailh C; Bhat MA. 2010. In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons. J Neurosci 30(14):4868-76. [PubMed: 20371806]  [MGI Ref ID J:159621]

Tian E; Kimura C; Takeda N; Aizawa S; Matsuo I. 2002. Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol 242(2):204-23. [PubMed: 11820816]  [MGI Ref ID J:74631]

Trichas G; Joyce B; Crompton LA; Wilkins V; Clements M; Tada M; Rodriguez TA; Srinivas S. 2011. Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm. PLoS Biol 9(2):e1001019. [PubMed: 21364967]  [MGI Ref ID J:170681]

Tsai MY; Yeh SD; Wang RS; Yeh S; Zhang C; Lin HY; Tzeng CR; Chang C. 2006. Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells. Proc Natl Acad Sci U S A 103(50):18975-80. [PubMed: 17142319]  [MGI Ref ID J:118270]

Tsai WC; Yang LY; Chen YC; Kao YH; Lin YK; Chen SA; Cheng CF; Chen YJ. 2013. Ablation of the androgen receptor gene modulates atrial electrophysiology and arrhythmogenesis with calcium protein dysregulation. Endocrinology 154(8):2833-42. [PubMed: 23748361]  [MGI Ref ID J:201773]

Uesaka T; Nagashimada M; Enomoto H. 2013. GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. J Neurosci 33(41):16372-82. [PubMed: 24107967]  [MGI Ref ID J:202753]

Uesaka T; Nagashimada M; Yonemura S; Enomoto H. 2008. Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. J Clin Invest 118(5):1890-8. [PubMed: 18414682]  [MGI Ref ID J:135153]

Valdez G; Heyer MP; Feng G; Sanes JR. 2014. The role of muscle microRNAs in repairing the neuromuscular junction. PLoS One 9(3):e93140. [PubMed: 24664281]  [MGI Ref ID J:215060]

Ventura A; Young AG; Winslow MM; Lintault L; Meissner A; Erkeland SJ; Newman J; Bronson RT; Crowley D; Stone JR; Jaenisch R; Sharp PA; Jacks T. 2008. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132(5):875-86. [PubMed: 18329372]  [MGI Ref ID J:134861]

Voronina VA; Kozlov S; Mathers PH; Lewandoski M. 2005. Conditional alleles for activation and inactivation of the mouse Rx homeobox gene. Genesis 41(4):160-4. [PubMed: 15789424]  [MGI Ref ID J:97314]

Wang C; Pan Y; Wang B. 2007. A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype. Dev Dyn 236(3):769-76. [PubMed: 17266131]  [MGI Ref ID J:118340]

Wang C; Pan Y; Wang B. 2010. Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 137(12):2001-9. [PubMed: 20463034]  [MGI Ref ID J:161408]

Wang L; Magdaleno S; Tabas I; Jackowski S. 2005. Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a). Mol Cell Biol 25(8):3357-63. [PubMed: 15798219]  [MGI Ref ID J:97657]

Warren SA; Briggs LE; Zeng H; Chuang J; Chang EI; Terada R; Li M; Swanson MS; Lecker SH; Willis MS; Spinale FG; Maupin-Furlowe J; McMullen JR; Moss RL; Kasahara H. 2012. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation 126(22):2575-88. [PubMed: 23095280]  [MGI Ref ID J:210147]

Weiner JA; Koo SJ; Nicolas S; Fraboulet S; Pfaff SL; Pourquie O; Sanes JR. 2004. Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci 27(1):59-69. [PubMed: 15345243]  [MGI Ref ID J:93205]

Wodarczyk C; Rowe I; Chiaravalli M; Pema M; Qian F; Boletta A. 2009. A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4(9):e7137. [PubMed: 19774080]  [MGI Ref ID J:153606]

Woo DK; Green PD; Santos JH; D'Souza AD; Walther Z; Martin WD; Christian BE; Chandel NS; Shadel GS. 2012. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol 180(1):24-31. [PubMed: 22056359]  [MGI Ref ID J:180188]

Xiang H; Noonan EJ; Wang J; Duan H; Ma L; Michie S; Boxer LM. 2011. The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. Leukemia 25(9):1484-93. [PubMed: 21606958]  [MGI Ref ID J:175730]

Xiang H; Wang J; Boxer LM. 2006. Role of the Cyclic AMP Response Element in the bcl-2 Promoter in the Regulation of Endogenous Bcl-2 Expression and Apoptosis in Murine B Cells. Mol Cell Biol 26(22):8599-606. [PubMed: 16982684]  [MGI Ref ID J:114637]

Xiao A; Wu H; Pandolfi PP; Louis DN; Van Dyke T. 2002. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1(2):157-68. [PubMed: 12086874]  [MGI Ref ID J:77132]

Yang B; Gillespie A; Carlson EJ; Epstein CJ; Verkman AS. 2001. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem 276(4):2775-9. [PubMed: 11035038]  [MGI Ref ID J:94003]

Yang C; McLeod AJ; Cotton AM; de Leeuw CN; Laprise S; Banks KG; Simpson EM; Brown CJ. 2012. Targeting of >1.5 Mb of human DNA into the mouse X chromosome reveals presence of cis-acting regulators of epigenetic silencing. Genetics 192(4):1281-93. [PubMed: 23023002]  [MGI Ref ID J:193936]

Yang F; Gell K; van der Heijden GW; Eckardt S; Leu NA; Page DC; Benavente R; Her C; Hoog C; McLaughlin KJ; Wang PJ. 2008. Meiotic failure in male mice lacking an X-linked factor. Genes Dev 22(5):682-91. [PubMed: 18316482]  [MGI Ref ID J:131722]

Ye M; Iwasaki H; Laiosa CV; Stadtfeld M; Xie H; Heck S; Clausen B; Akashi K; Graf T. 2003. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19(5):689-99. [PubMed: 14614856]  [MGI Ref ID J:174583]

Yeh JR; Ju R; Brdlik CM; Zhang W; Zhang Y; Matyskiela ME; Shotwell JD; Crews CM. 2006. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A 103(27):10379-84. [PubMed: 16790550]  [MGI Ref ID J:111701]

Yeh S; Hu YC; Wang PH; Xie C; Xu Q; Tsai MY; Dong Z; Wang RS; Lee TH; Chang C. 2003. Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198(12):1899-908. [PubMed: 14676301]  [MGI Ref ID J:87193]

Yeh S; Tsai MY; Xu Q; Mu XM; Lardy H; Huang KE; Lin H; Yeh SD; Altuwaijri S; Zhou X; Xing L; Boyce BF; Hung MC; Zhang S; Gan L; Chang C; Hung MC. 2002. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A 99(21):13498-503. [PubMed: 12370412]  [MGI Ref ID J:81789]

Yin H; Copley CO; Goodrich LV; Deans MR. 2012. Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One 7(2):e31988. [PubMed: 22363783]  [MGI Ref ID J:185311]

Yu K; Xu J; Liu Z; Sosic D; Shao J; Olson EN; Towler DA; Ornitz DM. 2003. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130(13):3063-74. [PubMed: 12756187]  [MGI Ref ID J:90391]

Zhang C; Yeh S; Chen YT; Wu CC; Chuang KH; Lin HY; Wang RS; Chang YJ; Mendis-Handagama C; Hu L; Lardy H; Chang C. 2006. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. Proc Natl Acad Sci U S A 103(47):17718-23. [PubMed: 17095600]  [MGI Ref ID J:117118]

Zhang J; Wright KD; Mahoney Rogers AA; Barrett MM; Shim K. 2014. Compensatory regulation of the size of the inner ear in response to excess induction of otic progenitors by fibroblast growth factor signaling. Dev Dyn 243(10):1317-27. [PubMed: 24847848]  [MGI Ref ID J:214309]

Zhang M; Angata T; Cho JY; Miller M; Broide DH; Varki A. 2007. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood 109(10):4280-7. [PubMed: 17272508]  [MGI Ref ID J:204811]

Zhang Y; Stehling-Sun S; Lezon-Geyda K; Juneja SC; Coillard L; Chatterjee G; Wuertzer CA; Camargo F; Perkins AS. 2011. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood 118(14):3853-61. [PubMed: 21666053]  [MGI Ref ID J:178429]

Zhong W; Jiang MM; Schonemann MD; Meneses JJ; Pedersen RA; Jan LY; Jan YN. 2000. Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A 97(12):6844-9. [PubMed: 10841580]  [MGI Ref ID J:62712]

Zhou J; McCarrey JR; Wang PJ. 2013. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Biol Reprod 88(6):159. [PubMed: 23677977]  [MGI Ref ID J:199138]

Zhou J; Pan J; Eckardt S; Leu NA; McLaughlin KJ; Wang PJ. 2011. Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis. Mol Reprod Dev 78(4):241-9. [PubMed: 21308854]  [MGI Ref ID J:171521]

Zhou XZ; Huang P; Shi R; Lee TH; Lu G; Zhang Z; Bronson R; Lu KP. 2011. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest 121(4):1266-82. [PubMed: 21436583]  [MGI Ref ID J:171997]

Zhu H; Zhao J; Zhou W; Li H; Zhou R; Zhang L; Zhao H; Cao J; Zhu X; Hu H; Ma G; He L; Yao Z; Yao L; Guo X. 2012. Ndrg2 regulates vertebral specification in differentiating somites. Dev Biol 369(2):308-18. [PubMed: 22819676]  [MGI Ref ID J:187603]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes. Expected coat color from breeding:Albino

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2225.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2892.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.