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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names FVB/N-TgN(ACTB-Cre)2Mrt (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Dr. Gail Martin, University of California San Francisco Description
This Cre recombinase strain is under the human beta actin gene promoter. This strain expresses Cre recombinase in all cells of the embryo by the blastocyst stage of development. It is useful as a "deletor" mouse for virtually any genomic sequence flanked by loxP sites.
Control Information
| Control | ||
|---|---|---|
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of ACTB
View Strains carrying other alleles of ACTB (13 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(ACTB-cre)2Mrt | ||
|---|---|---|---|
| Allele Name | transgene insertion 2, Gail R Martin | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | A-cre; Act-Cre; TgN(ACTB-cre)2Mrt; actin-cre; beta-actin-Cre; beta-actin::Cre; beta-actin:Cre; creactin; | ||
| Mutation Made By | Dr. Gail Martin, University of California San Francisco | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | all cells of the embryo by the blastocyst stage of development; widespread expression | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | ACTB, actin, beta, human | ||
| Driver Note | ACTB | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. [MGI Ref ID J:46833] | ||
| Gene Symbol and Name | Tg(ACTB-cre)2Mrt, transgene insertion 2, Gail R Martin | ||
| Chromosome | UN | ||
| Gene Common Name(s) | A-cre; Act-Cre; TgN(ACTB-cre)2Mrt; actin-cre; beta-actin-Cre; beta-actin::Cre; beta-actin:Cre; creactin; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Lewandoski M; Meyers EN; Martin GR. 1997. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb Symp Quant Biol 62:159-68. [PubMed: 9598348] [MGI Ref ID J:46833]
Additional References
Moqrich A; Earley TJ; Watson J; Andahazy M; Backus C; Martin-Zanca D; Wright DE; Reichardt LF; Patapoutian A. 2004. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci 7(8):812-8. [PubMed: 15247919] [MGI Ref ID J:92099]
Tg(ACTB-cre)2Mrt relatedAbdulkadir SA; Magee JA; Peters TJ; Kaleem Z; Naughton CK; Humphrey PA; Milbrandt J. 2002. Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22(5):1495-503. [PubMed: 11839815] [MGI Ref ID J:74350]
Altuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 23(4):444-53. [PubMed: 19164450] [MGI Ref ID J:146896]
Amable L; Grankvist N; Largen JW; Ortsater H; Sjoholm A; Honkanen RE. 2011. Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1). J Biol Chem 286(47):40413-22. [PubMed: 21921034] [MGI Ref ID J:178164]
Andoniadou CL; Signore M; Sajedi E; Gaston-Massuet C; Kelberman D; Burns AJ; Itasaki N; Dattani M; Martinez-Barbera JP. 2007. Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development 134(8):1499-508. [PubMed: 17360769] [MGI Ref ID J:135132]
Arnold JS; Werling U; Braunstein EM; Liao J; Nowotschin S; Edelmann W; Hebert JM; Morrow BE. 2006. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133(5):977-87. [PubMed: 16452092] [MGI Ref ID J:105980]
Asai N; Fukuda T; Wu Z; Enomoto A; Pachnis V; Takahashi M; Costantini F. 2006. Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133(22):4507-16. [PubMed: 17050626] [MGI Ref ID J:116089]
Awatramani R; Soriano P; Rodriguez C; Mai JJ; Dymecki SM. 2003. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35(1):70-5. [PubMed: 12923530] [MGI Ref ID J:128980]
Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616] [MGI Ref ID J:130978]
Baba M; Keller JR; Sun HW; Resch W; Kuchen S; Suh HC; Hasumi H; Hasumi Y; Kieffer-Kwon KR; Gonzalez CG; Hughes RM; Klein ME; Oh HF; Bible P; Southon E; Tessarollo L; Schmidt LS; Linehan WM; Casellas R. 2012. The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development. Blood 120(6):1254-61. [PubMed: 22709692] [MGI Ref ID J:189078]
Balciuniene J; Bardwell VJ; Zarkower D. 2006. Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles. Mol Cell Biol 26(23):8984-91. [PubMed: 16982677] [MGI Ref ID J:118110]
Basson MA; Akbulut S; Watson-Johnson J; Simon R; Carroll TJ; Shakya R; Gross I; Martin GR; Lufkin T; McMahon AP; Wilson PD; Costantini FD; Mason IJ; Licht JD. 2005. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 8(2):229-39. [PubMed: 15691764] [MGI Ref ID J:96485]
Bisgrove BW; Makova S; Yost HJ; Brueckner M. 2012. RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol 363(1):166-78. [PubMed: 22233545] [MGI Ref ID J:182770]
Biswas K; Das R; Eggington JM; Qiao H; North SL; Stauffer S; Burkett SS; Martin BK; Southon E; Sizemore SC; Pruss D; Bowles KR; Roa BB; Hunter N; Tessarollo L; Wenstrup RJ; Byrd RA; Sharan SK. 2012. Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet 21(18):3993-4006. [PubMed: 22678057] [MGI Ref ID J:187434]
Bloom AJ; Miller BR; Sanes JR; Diantonio A. 2007. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev 21(20):2593-606. [PubMed: 17901218] [MGI Ref ID J:125702]
Brantley MA Jr; Jain S; Barr EE; Johnson EM Jr; Milbrandt J. 2008. Neurturin-mediated ret activation is required for retinal function. J Neurosci 28(16):4123-35. [PubMed: 18417692] [MGI Ref ID J:134527]
Brown D; Yu BD; Joza N; Benit P; Meneses J; Firpo M; Rustin P; Penninger JM; Martin GR. 2006. Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A 103(26):9918-23. [PubMed: 16788063] [MGI Ref ID J:111066]
Buffelli M; Burgess RW; Feng G; Lobe CG; Lichtman JW; Sanes JR. 2003. Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature 424(6947):430-4. [PubMed: 12879071] [MGI Ref ID J:89596]
Buttermore ED; Dupree JL; Cheng J; An X; Tessarollo L; Bhat MA. 2011. The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci 31(22):8013-8024. [PubMed: 21632923] [MGI Ref ID J:173383]
Buttermore ED; Piochon C; Wallace ML; Philpot BD; Hansel C; Bhat MA. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci 32(14):4724-42. [PubMed: 22492029] [MGI Ref ID J:184009]
Callis TE; Pandya K; Seok HY; Tang RH; Tatsuguchi M; Huang ZP; Chen JF; Deng Z; Gunn B; Shumate J; Willis MS; Selzman CH; Wang DZ. 2009. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 119(9):2772-86. [PubMed: 19726871] [MGI Ref ID J:152696]
Campbell S; Burkly LC; Gao HX; Berman JW; Su L; Browning B; Zheng T; Schiffer L; Michaelson JS; Putterman C. 2006. Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol 176(3):1889-98. [PubMed: 16424220] [MGI Ref ID J:126416]
Chen M; Hsu I; Wolfe A; Radovick S; Huang K; Yu S; Chang C; Messing EM; Yeh S. 2009. Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology 150(1):251-9. [PubMed: 18755802] [MGI Ref ID J:147000]
Chen M; Wolfe A; Wang X; Chang C; Yeh S; Radovick S. 2009. Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. Mol Cell Biochem 321(1-2):145-53. [PubMed: 18953638] [MGI Ref ID J:147191]
Chen M; Yeh CR; Chang HC; Vitkus S; Wen XQ; Bhowmick NA; Wolfe A; Yeh S. 2012. Loss of epithelial oestrogen receptor alpha inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. J Pathol 226(1):17-27. [PubMed: 22069040] [MGI Ref ID J:180158]
Chen MH; Gao N; Kawakami T; Chuang PT. 2005. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol 25(16):7042-53. [PubMed: 16055716] [MGI Ref ID J:131268]
Chen MH; Li YJ; Kawakami T; Xu SM; Chuang PT. 2004. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 18(6):641-59. [PubMed: 15075292] [MGI Ref ID J:89228]
Cheng X; Hsu CM; Currle DS; Hu JS; Barkovich AJ; Monuki ES. 2006. Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci 26(29):7640-9. [PubMed: 16855091] [MGI Ref ID J:110657]
Cheng Y; Buffone MG; Kouadio M; Goodheart M; Page DC; Gerton GL; Davidson I; Wang PJ. 2007. Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol 27(7):2582-9. [PubMed: 17242199] [MGI Ref ID J:121371]
Chia IV; Costantini F. 2005. Mouse axin and axin2/conductin proteins are functionally equivalent in vivo. Mol Cell Biol 25(11):4371-6. [PubMed: 15899843] [MGI Ref ID J:98893]
Chia IV; Kim MJ; Itoh K; Sokol SY; Costantini F. 2009. Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis. Genetics 181(4):1359-68. [PubMed: 19204372] [MGI Ref ID J:147293]
Chizhikov VV; Lindgren AG; Currle DS; Rose MF; Monuki ES; Millen KJ. 2006. The roof plate regulates cerebellar cell-type specification and proliferation. Development 133(15):2793-804. [PubMed: 16790481] [MGI Ref ID J:119033]
Christiansen JR; Kolandaivelu S; Bergo MO; Ramamurthy V. 2011. RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Natl Acad Sci U S A 108(21):8862-6. [PubMed: 21555557] [MGI Ref ID J:171900]
Chuang KH; Altuwaijri S; Li G; Lai JJ; Chu CY; Lai KP; Lin HY; Hsu JW; Keng P; Wu MC; Chang C. 2009. Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J Exp Med 206(5):1181-99. [PubMed: 19414555] [MGI Ref ID J:148491]
Coppola V; Barrick CA; Bobisse S; Rodriguez-Galan MC; Pivetta M; Reynolds D; Howard OM; Palko ME; Esteban PF; Young HA; Rosato A; Tessarollo L. 2006. The scaffold protein cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Mol Cell Biol 26(14):5249-58. [PubMed: 16809763] [MGI Ref ID J:110320]
Cubelos B; Sebastian-Serrano A; Kim S; Moreno-Ortiz C; Redondo JM; Walsh CA; Nieto M. 2008. Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone. Cereb Cortex 18(8):1758-70. [PubMed: 18033766] [MGI Ref ID J:156578]
Currle DS; Cheng X; Hsu CM; Monuki ES. 2005. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. Development 132(15):3549-59. [PubMed: 15975937] [MGI Ref ID J:100435]
Danielian PS; Friesenhahn LB; Faust AM; West JC; Caron AM; Bronson RT; Lees JA. 2008. E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene 27(51):6561-70. [PubMed: 18663357] [MGI Ref ID J:147270]
Diggle CP; Shires M; McRae C; Crellin D; Fisher J; Carr IM; Markham AF; Hayward BE; Asipu A; Bonthron DT. 2010. Both isoforms of ketohexokinase are dispensable for normal growth and development. Physiol Genomics 42A(4):235-43. [PubMed: 20841500] [MGI Ref ID J:166959]
Diril MK; Ratnacaram CK; Padmakumar VC; Du T; Wasser M; Coppola V; Tessarollo L; Kaldis P. 2012. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A 109(10):3826-31. [PubMed: 22355113] [MGI Ref ID J:182141]
Dowdle WE; Robinson JF; Kneist A; Sirerol-Piquer MS; Frints SG; Corbit KC; Zaghloul NA; van Lijnschoten G; Mulders L; Verver DE; Zerres K; Reed RR; Attie-Bitach T; Johnson CA; Garcia-Verdugo JM; Katsanis N; Bergmann C; Reiter JF. 2011. Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet 89(1):94-110. [PubMed: 21763481] [MGI Ref ID J:178421]
Enshell-Seijffers D; Lindon C; Kashiwagi M; Morgan BA. 2010. beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell 18(4):633-42. [PubMed: 20412777] [MGI Ref ID J:160311]
Enshell-Seijffers D; Lindon C; Wu E; Taketo MM; Morgan BA. 2010. {beta}-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc Natl Acad Sci U S A :. [PubMed: 21098273] [MGI Ref ID J:167151]
Eswarakumar VP; Schlessinger J. 2007. Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A 104(10):3937-42. [PubMed: 17360456] [MGI Ref ID J:142946]
Farago AF; Awatramani RB; Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50(2):205-18. [PubMed: 16630833] [MGI Ref ID J:133039]
Ferguson C; Hardy SL; Werner DF; Hileman SM; Delorey TM; Homanics GE. 2007. New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci 8:85. [PubMed: 17927825] [MGI Ref ID J:127877]
Ferguson SM; Raimondi A; Paradise S; Shen H; Mesaki K; Ferguson A; Destaing O; Ko G; Takasaki J; Cremona O; O' Toole E; De Camilli P. 2009. Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell 17(6):811-22. [PubMed: 20059951] [MGI Ref ID J:161127]
Galvao RP; Garcia-Verdugo JM; Alvarez-Buylla A. 2008. Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats. J Neurosci 28(50):13368-83. [PubMed: 19074010] [MGI Ref ID J:143055]
Gao B; Hu J; Stricker S; Cheung M; Ma G; Law KF; Witte F; Briscoe J; Mundlos S; He L; Cheah KS; Chan D. 2009. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458(7242):1196-200. [PubMed: 19252479] [MGI Ref ID J:147878]
Garcia M; Leonardi R; Zhang YM; Rehg JE; Jackowski S. 2012. Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. PLoS One 7(7):e40871. [PubMed: 22815849] [MGI Ref ID J:189609]
Gardiner JR; Jackson AL; Gordon J; Lickert H; Manley NR; Basson MA. 2012. Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development 139(18):3456-66. [PubMed: 22912418] [MGI Ref ID J:187709]
Garrett AM; Weiner JA. 2009. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. J Neurosci 29(38):11723-31. [PubMed: 19776259] [MGI Ref ID J:153046]
Goh AM; Lim CY; Chiam PC; Li L; Mann MB; Mann KM; Menendez S; Lane DP. 2012. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A 109(5):1685-90. [PubMed: 22307631] [MGI Ref ID J:182031]
Gould TW; Yonemura S; Oppenheim RW; Ohmori S; Enomoto H. 2008. The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci 28(9):2131-46. [PubMed: 18305247] [MGI Ref ID J:132854]
Grieshammer U; Lewandoski M; Prevette D; Oppenheim RW; Martin GR. 1998. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Dev Biol 197(2):234-47. [PubMed: 9630749] [MGI Ref ID J:127216]
Hanada R; Leibbrandt A; Hanada T; Kitaoka S; Furuyashiki T; Fujihara H; Trichereau J; Paolino M; Qadri F; Plehm R; Klaere S; Komnenovic V; Mimata H; Yoshimatsu H; Takahashi N; von Haeseler A; Bader M; Kilic SS; Ueta Y; Pifl C; Narumiya S; Penninger JM. 2009. Central control of fever and female body temperature by RANKL/RANK. Nature 462(7272):505-9. [PubMed: 19940926] [MGI Ref ID J:155398]
Hayashi M; Kim SW; Imanaka-Yoshida K; Yoshida T; Abel ED; Eliceiri B; Yang Y; Ulevitch RJ; Lee JD. 2004. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest 113(8):1138-48. [PubMed: 15085193] [MGI Ref ID J:89215]
He B; Deckelbaum RA; Miao D; Lipman ML; Pollak M; Goltzman D; Karaplis AC. 2001. Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles. Endocrinology 142(5):2070-7. [PubMed: 11316774] [MGI Ref ID J:69396]
He Y; Zu T; Benzow KA; Orr HT; Clark HB; Koob MD. 2006. Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits. J Neurosci 26(39):9975-82. [PubMed: 17005861] [MGI Ref ID J:112937]
Hoshi M; Batourina E; Mendelsohn C; Jain S. 2012. Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice. Development 139(13):2405-15. [PubMed: 22627285] [MGI Ref ID J:185532]
Howard S; Deroo T; Fujita Y; Itasaki N. 2011. A Positive Role of Cadherin in Wnt/beta-Catenin Signalling during Epithelial-Mesenchymal Transition. PLoS One 6(8):e23899. [PubMed: 21909376] [MGI Ref ID J:176131]
Jain S; Golden JP; Wozniak D; Pehek E; Johnson EM Jr; Milbrandt J. 2006. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci 26(43):11230-8. [PubMed: 17065462] [MGI Ref ID J:114682]
Jain S; Naughton CK; Yang M; Strickland A; Vij K; Encinas M; Golden J; Gupta A; Heuckeroth R; Johnson EM Jr; Milbrandt J. 2004. Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development 131(21):5503-13. [PubMed: 15469971] [MGI Ref ID J:93262]
Joza N; Oudit GY; Brown D; Benit P; Kassiri Z; Vahsen N; Benoit L; Patel MM; Nowikovsky K; Vassault A; Backx PH; Wada T; Kroemer G; Rustin P; Penninger JM. 2005. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol 25(23):10261-72. [PubMed: 16287843] [MGI Ref ID J:113016]
Kao AW; Eisenhut RJ; Martens LH; Nakamura A; Huang A; Bagley JA; Zhou P; de Luis A; Neukomm LJ; Cabello J; Farese RV Jr; Kenyon C. 2011. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A 108(11):4441-6. [PubMed: 21368173] [MGI Ref ID J:170823]
Kiefer SM; Robbins L; Rauchman M. 2012. Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function. PLoS One 7(8):e43098. [PubMed: 22912798] [MGI Ref ID J:189974]
Kim DS; Matsuda T; Cepko CL. 2008. A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J Neurosci 28(31):7748-64. [PubMed: 18667607] [MGI Ref ID J:139494]
Kim JC; Cook MN; Carey MR; Shen C; Regehr WG; Dymecki SM. 2009. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron 63(3):305-15. [PubMed: 19679071] [MGI Ref ID J:154944]
Klein OD; Minowada G; Peterkova R; Kangas A; Yu BD; Lesot H; Peterka M; Jernvall J; Martin GR. 2006. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell 11(2):181-90. [PubMed: 16890158] [MGI Ref ID J:119280]
Koss M; Bolze A; Brendolan A; Saggese M; Capellini TD; Bojilova E; Boisson B; Prall OW; Elliott DA; Solloway M; Lenti E; Hidaka C; Chang CP; Mahlaoui N; Harvey RP; Casanova JL; Selleri L. 2012. Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell 22(5):913-26. [PubMed: 22560297] [MGI Ref ID J:184521]
Krimpenfort P; Ijpenberg A; Song JY; van der Valk M; Nawijn M; Zevenhoven J; Berns A. 2007. p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature 448(7156):943-6. [PubMed: 17713536] [MGI Ref ID J:125189]
Kriz V; Mares J; Wentzel P; Funa NS; Calounova G; Zhang XQ; Forsberg-Nilsson K; Forsberg M; Welsh M. 2007. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Dev Dyn 236(9):2485-92. [PubMed: 17676633] [MGI Ref ID J:124188]
Kuslak SL; Thielen JL; Marker PC. 2007. The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134(3):557-65. [PubMed: 17202188] [MGI Ref ID J:119935]
Kuznetsov S; Pellegrini M; Shuda K; Fernandez-Capetillo O; Liu Y; Martin BK; Burkett S; Southon E; Pati D; Tessarollo L; West SC; Donovan PJ; Nussenzweig A; Sharan SK. 2007. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol 176(5):581-92. [PubMed: 17312021] [MGI Ref ID J:119835]
Kuznetsov SG; Haines DC; Martin BK; Sharan SK. 2009. Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res 69(3):863-72. [PubMed: 19155299] [MGI Ref ID J:144977]
Lai JJ; Lai KP; Chuang KH; Chang P; Yu IC; Lin WJ; Chang C. 2009. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest 119(12):3739-51. [PubMed: 19907077] [MGI Ref ID J:155101]
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Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
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Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry The strain originated on and is currently on an FVB/N background. Homozygotes are viable and fertile. Expected coat color from breeding:Albino Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.