Description

Strain Information

Former Names B6;129S2-Srb1tm1Kri    (Changed: 15-DEC-04 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System +/+ sibling x Heterozygote         (Female x Male) Species laboratory mouse Generation F?+18 (08-JAN-08)   Donating Investigator Monty Krieger,   Massachusetts Institute of Technology

Description
The class B, type I scavenger receptor (Srb1 or Scarb1) is a cell surface HDL receptor that can recognize the apolipoproteins on the surface of the HDL particle. It plays a key role in determining the levels of plasma lipoprotein cholesterol (primarily HDL) and the accumulation of cholesterol stores in the adrenal gland.In this strain plasma cholesterol (primarily HDL) concentrations increase by 31% in heterozygotes and 125% in homozygotes, as compared to wild type controls. Also, cholesterol levels in adrenal tissue in heterozygous and homozygous mutants decrease by 42% and 72% respectively, relative to wild type controls. The plasma concentration of Apoa-I, the major protein in HDL, is unchanged in mutant animals, relative to wild type controls.Homozygous females are infertile; homozygous males are fertile. Please note that the donating investigator reports that the number of homozygotes resulting from a cross between heterozygotes is significantly lower than what the expected Mendelian ratio would predict.

Development
The strain was made with replacement of a portion of the first coding exon (including the initiator ATG and sequences encoding a putative membrane spanning region) with a neomycin resistance gene.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Scarb1^tm1Kri allele

004362

B6;129-Scarb1tm1Kri Apoetm1Unc/J

View Strains carrying   Scarb1^tm1Kri     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Scarb1^tm1Kri/Scarb1⁺

        involves: 129S2/SvPas * C57BL/6

• homeostasis/metabolism phenotype
• abnormal lipid homeostasis (MGI Ref ID J:44187)
• abnormal cholesterol level (MGI Ref ID J:44187)
• increased circulating cholesterol level (MGI Ref ID J:44187)
  • plasma cholesterol concentration increased by ~31%
• endocrine/exocrine gland phenotype
• abnormal adrenal gland physiology (MGI Ref ID J:44187)
  • cholesterol content decreased by 42%

Scarb1^tm1Kri/Scarb1^tm1Kri

        involves: 129S2/SvPas * C57BL/6

• homeostasis/metabolism phenotype
• abnormal lipid homeostasis (MGI Ref ID J:44187)
• abnormal cholesterol level (MGI Ref ID J:44187)
• abnormal circulating cholesterol level (MGI Ref ID J:73138)
  • plasma total cholesterol is abnormally high
  • most of the cholesterol is found as abnormally large particles
• increased circulating cholesterol level (MGI Ref ID J:44187)
  • plasma concentrations are 125% of control values
  • concentration increase is due to formation of large particles containing apolipoprotein A-1
• endocrine/exocrine gland phenotype
• abnormal adrenal gland physiology (MGI Ref ID J:44187)
  • cholesterol content is 72% lower than normal
• lethality-prenatal/perinatal
• perinatal lethality (MGI Ref ID J:105226)
  • the occasional offspring produced by homozygous mothers die soon after birth
• prenatal lethality (MGI Ref ID J:105226)
  • the majority of harvested one cell embryos had abnormal,nonrefractile morphology
  • in vitro development of embryos arrests by the 2 cell stage
• reproductive system phenotype
• abnormal oocyte morphology (MGI Ref ID J:105226)
  • some superovulated oocytes have an abnormal morphology
• female infertility (MGI Ref ID J:105226)
  • only occasionally will a pup be born
  • inactivation of the apolipoprotein A-1 gene or administration of the cholesterol-lowering drug probucol restored fertility
  • inactivation of the apolipoprotein A-1 gene or administration of the cholesterol-lowering drug probucol restored fertility
• hematopoietic system phenotype
• abnormal erythrocyte morphology (MGI Ref ID J:75090)
  • red blood cells with cytoplasmic irregularities
  • mitochondria present in about 15% of red blood cells
• macrocytosis (MGI Ref ID J:75090)
• poikilocytosis (MGI Ref ID J:75090)
  • sometimes
• anemia (MGI Ref ID J:75090)
  • mild
  • exacerbated on a high cholesterol diet

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Scarb1^tm1Kri/Scarb1^tm1Kri

        B6.129S2-Scarb1^tm1Kri

• reproductive system phenotype
• female infertility (MGI Ref ID J:73138)
  • only occasionally is a pup born

Scarb1^tm1Kri/Scarb1^tm1Kri

        involves: 129S2/SvPas

• cardiovascular system phenotype
• abnormal blood vessel healing (MGI Ref ID J:118063)
  • reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
  • mice exhibit a 44% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice
• homeostasis/metabolism phenotype
• abnormal blood vessel healing (MGI Ref ID J:118063)
  • reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
  • mice exhibit a 44% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Scarb1^tm1Kri related

Cardiovascular Research
Hypercholesterolemia

Metabolism Research
Lipid Metabolism

Reproductive Biology Research
Fertility Defects (females only)

Genes & Alleles

Gene & Allele Information

Allele Symbol		Scarb1tm1Kri
Allele Name		targeted mutation 1, Monty Krieger
Allele Type		Targeted (knock-out)
Common Name(s)		SR-BI; SR-BI-; srb1-; srbI-;
Mutation Made By		Monty Krieger,   Massachusetts Institute of Technology
Strain of Origin		129S2/SvPas
ES Cell Line Name		D3
ES Cell Line Strain		129S2/SvPas
Gene Symbol and Name		Scarb1, scavenger receptor class B, member 1
Chromosome		5
Gene Common Name(s)		AI120173; CD36L1; CLA-1; CLA1; D5Ertd460e; DNA segment, Chr 5, ERATO Doi 460, expressed; MGC138242; SR-B1; SR-BI; SRB1; SRBI; Srb1; expressed sequence AI120173; scavenger receptor class B1;
Molecular Note		Replacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette. [MGI Ref ID J:44187]

Genotyping

Genotyping Information

Genotyping Protocols

Scarb1^tm1Kri, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Rigotti A; Trigatti BL; Penman M; Rayburn H; Herz J; Krieger M. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A 94(23):12610-5. [PubMed: 9356497]  [MGI Ref ID J:44187]

Additional References

Scarb1^tm1Kri related

Adorni MP; Zimetti F; Billheimer JT; Wang N; Rader DJ; Phillips MC; Rothblat GH. 2007. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48(11):2453-62. [PubMed: 17761631]  [MGI Ref ID J:127358]

Altmann SW; Davis HR; Yao X; Laverty M; Compton DS; Zhu L; Crona JH; Caplen MA; Hoos LM; Tetzloff G; Priestley T; Burnett DA; Strader CD; Graziano MP. 2002. The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption. Biochim Biophys Acta 1580(1):77-93. [PubMed: 11923102]  [MGI Ref ID J:75435]

Braun A; Trigatti BL; Post MJ; Sato K; Simons M; Edelberg JM; Rosenberg RD; Schrenzel M; Krieger M. 2002. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res 90(3):270-6. [PubMed: 11861414]  [MGI Ref ID J:109751]

Braun A; Zhang S; Miettinen HE; Ebrahim S; Holm TM; Vasile E; Post MJ; Yoerger DM; Picard MH; Krieger JL; Andrews NC; Simons M; Krieger M. 2003. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse. Proc Natl Acad Sci U S A 100(12):7283-8. [PubMed: 12771386]  [MGI Ref ID J:83785]

Bravo I; Amigo L; Cohen DE; Nervi F; Rigotti A; Francone O; Zanlungo S. 2007. Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse. Biochim Biophys Acta 1770(6):979-88. [PubMed: 17399905]  [MGI Ref ID J:121757]

Brodeur MR; Luangrath V; Bourret G; Falstrault L; Brissette L. 2005. Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. J Lipid Res 46(4):687-96. [PubMed: 15654132]  [MGI Ref ID J:98578]

Cai L; Ji A; de Beer FC; Tannock LR; van der Westhuyzen DR. 2008. SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance. J Clin Invest 118(1):364-75. [PubMed: 18064300]  [MGI Ref ID J:130849]

Callow MJ; Dudoit S; Gong EL; Speed TP; Rubin EM. 2000. Microarray expression profiling identifies genes with altered expression in HDL-deficient mice. Genome Res 10(12):2022-9. [PubMed: 11116096]  [MGI Ref ID J:115384]

Drover VA; Nguyen DV; Bastie CC; Darlington YF; Abumrad NA; Pessin JE; London E; Sahoo D; Phillips MC. 2008. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem 283(19):13108-15. [PubMed: 18332148]  [MGI Ref ID J:137082]

Harder C; Lau P; Meng A; Whitman SC; McPherson R. 2007. Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice. Arterioscler Thromb Vasc Biol 27(4):858-64. [PubMed: 17272756]  [MGI Ref ID J:128221]

Hoekstra M; Meurs I; Koenders M; Out R; Hildebrand RB; Kruijt JK; Van Eck M; Van Berkel TJ. 2008. Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting. J Lipid Res 49(4):738-45. [PubMed: 18204096]  [MGI Ref ID J:133584]

Holm TM; Braun A; Trigatti BL; Brugnara C; Sakamoto M; Krieger M; Andrews NC. 2002. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood 99(5):1817-24. [PubMed: 11861300]  [MGI Ref ID J:75090]

Karackattu SL; Picard MH; Krieger M. 2005. Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 25(4):803-8. [PubMed: 15692099]  [MGI Ref ID J:110023]

Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 26(3):548-54. [PubMed: 16397139]  [MGI Ref ID J:127979]

Kocher O; Yesilaltay A; Shen CH; Zhang S; Daniels K; Pal R; Chen J; Krieger M. 2008. Influence of PDZK1 on lipoprotein metabolism and atherosclerosis. Biochim Biophys Acta 1782(5):310-6. [PubMed: 18342019]  [MGI Ref ID J:136729]

Lee JY; Badeau RM; Mulya A; Boudyguina E; Gebre AK; Smith TL; Parks JS. 2007. Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice. J Lipid Res 48(5):1052-61. [PubMed: 17272829]  [MGI Ref ID J:121837]

Li XA; Guo L; Asmis R; Nikolova-Karakashian M; Smart EJ. 2006. Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death. Circ Res 98(7):e60-5. [PubMed: 16574909]  [MGI Ref ID J:121399]

Li XA; Guo L; Dressman JL; Asmis R; Smart EJ. 2005. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem 280(19):19087-96. [PubMed: 15749707]  [MGI Ref ID J:99934]

Ma K; Forte T; Otvos JD; Chan L. 2005. Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models. Arterioscler Thromb Vasc Biol 25(1):149-54. [PubMed: 15539616]  [MGI Ref ID J:109812]

Mardones P; Quinones V; Amigo L; Moreno M; Miquel JF; Schwarz M; Miettinen HE; Trigatti B; Krieger M; VanPatten S; Cohen DE; Rigotti A. 2001. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J Lipid Res 42(2):170-80. [PubMed: 11181745]  [MGI Ref ID J:68352]

Mardones P; Strobel P; Miranda S; Leighton F; Quinones V; Amigo L; Rozowski J; Krieger M; Rigotti A. 2002. Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice. J Nutr 132(3):443-9. [PubMed: 11880569]  [MGI Ref ID J:75363]

Meurs I; Hoekstra M; van Wanrooij EJ; Hildebrand RB; Kuiper J; Kuipers F; Hardeman MR; Van Berkel TJ; Van Eck M. 2005. HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes. Exp Hematol 33(11):1309-19. [PubMed: 16263415]  [MGI Ref ID J:102414]

Miettinen HE; Rayburn H; Krieger M. 2001. Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice. J Clin Invest 108(11):1717-22. [PubMed: 11733567]  [MGI Ref ID J:73138]

Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. [PubMed: 18175806]  [MGI Ref ID J:133757]

Out R; Hoekstra M; Spijkers JA; Kruijt JK; van Eck M; Bos IS; Twisk J; Van Berkel TJ. 2004. Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice. J Lipid Res 45(11):2088-95. [PubMed: 15314100]  [MGI Ref ID J:94153]

Out R; Kruijt JK; Rensen PC; Hildebrand RB; de Vos P; Van Eck M; Van Berkel TJ. 2004. Scavenger receptor BI plays a role in facilitating chylomicron metabolism. J Biol Chem 279(18):18401-6. [PubMed: 14970197]  [MGI Ref ID J:124241]

Seetharam D; Mineo C; Gormley AK; Gibson LL; Vongpatanasin W; Chambliss KL; Hahner LD; Cummings ML; Kitchens RL; Marcel YL; Rader DJ; Shaul PW. 2006. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res 98(1):63-72. [PubMed: 16339487]  [MGI Ref ID J:118063]

Tanigawa H; Billheimer JT; Tohyama J; Zhang Y; Rothblat G; Rader DJ. 2007. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation 116(11):1267-73. [PubMed: 17709636]  [MGI Ref ID J:139845]

Trigatti B; Rayburn H; Vinals M; Braun A; Miettinen H; Penman M; Hertz M; Schrenzel M; Amigo L; Rigotti A; Krieger M. 1999. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Natl Acad Sci U S A 96(16):9322-7. [PubMed: 10430941]  [MGI Ref ID J:105226]

Van Eck M; Bos IS; Hildebrand RB; Van Rij BT; Van Berkel TJ. 2004. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am J Pathol 165(3):785-94. [PubMed: 15331403]  [MGI Ref ID J:92320]

Van Eck M; Hoekstra M; Hildebrand RB; Yaong Y; Stengel D; Kruijt JK; Sattler W; Tietge UJ; Ninio E; Van Berkel TJ; Pratico D. 2007. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL. Arterioscler Thromb Vasc Biol 27(11):2413-9. [PubMed: 17717299]  [MGI Ref ID J:134874]

Van Eck M; Hoekstra M; Out R; Bos IS; Kruijt JK; Hildebrand RB; Van Berkel TJ. 2008. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. J Lipid Res 49(1):136-46. [PubMed: 17954936]  [MGI Ref ID J:130302]

Van Eck M; Twisk J; Hoekstra M; Van Rij BT; Van der Lans CA; Bos IS; Kruijt JK; Kuipers F; Van Berkel TJ. 2003. Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J Biol Chem 278(26):23699-705. [PubMed: 12639961]  [MGI Ref ID J:84112]

Vishnyakova TG; Kurlander R; Bocharov AV; Baranova IN; Chen Z; Abu-Asab MS; Tsokos M; Malide D; Basso F; Remaley A; Csako G; Eggerman TL; Patterson AP. 2006. CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells. Proc Natl Acad Sci U S A 103(45):16888-93. [PubMed: 17071747]  [MGI Ref ID J:117112]

Wang MD; Kiss RS; Franklin V; McBride HM; Whitman SC; Marcel YL. 2007. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48(3):633-45. [PubMed: 17148552]  [MGI Ref ID J:120283]

Wang X; Collins HL; Ranalletta M; Fuki IV; Billheimer JT; Rothblat GH; Tall AR; Rader DJ. 2007. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117(8):2216-24. [PubMed: 17657311]  [MGI Ref ID J:123959]

Williams DL; Wong JS; Hamilton RL. 2002. SR-BI is required for microvillar channel formation and the localization of HDL particles to the surface of adrenocortical cells in vivo. J Lipid Res 43(4):544-9. [PubMed: 11907136]  [MGI Ref ID J:75696]

Xie C; Richardson JA; Turley SD; Dietschy JM. 2006. Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein. J Lipid Res 47(5):953-63. [PubMed: 16461760]  [MGI Ref ID J:109000]

Yancey PG; Jerome WG; Yu H; Griffin EE; Cox BE; Babaev VR; Fazio S; Linton MF. 2007. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res 48(5):1140-9. [PubMed: 17299204]  [MGI Ref ID J:121848]

Yesilaltay A; Kocher O; Pal R; Leiva A; Quinones V; Rigotti A; Krieger M. 2006. PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function. J Biol Chem 281(39):28975-80. [PubMed: 16867981]  [MGI Ref ID J:116925]

Yu H; Zhang W; Yancey PG; Koury MJ; Zhang Y; Fazio S; Linton MF. 2006. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. Arterioscler Thromb Vasc Biol 26(1):150-6. [PubMed: 16269665]  [MGI Ref ID J:127962]

Yvan-Charvet L; Pagler TA; Wang N; Senokuchi T; Brundert M; Li H; Rinninger F; Tall AR. 2008. SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. J Lipid Res 49(1):107-14. [PubMed: 17960026]  [MGI Ref ID J:130277]

Zhang S; Picard MH; Vasile E; Zhu Y; Raffai RL; Weisgraber KH; Krieger M. 2005. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111(25):3457-64. [PubMed: 15967843]  [MGI Ref ID J:114611]

Zhang W; Yancey PG; Su YR; Babaev VR; Zhang Y; Fazio S; Linton MF. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 108(18):2258-63. [PubMed: 14581413]  [MGI Ref ID J:103014]

Zhang Y; Da Silva JR; Reilly M; Billheimer JT; Rothblat GH; Rader DJ. 2005. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 115(10):2870-4. [PubMed: 16200214]  [MGI Ref ID J:101524]

van der Velde AE; Vrins CL; van den Oever K; Seemann I; Oude Elferink RP; van Eck M; Kuipers F; Groen AK. 2008. Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol 295(1):G203-G208. [PubMed: 18511744]  [MGI Ref ID J:137834]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & Husbandry	The strain originated on a mixed B6,129 background and is currently on the same background. Homozygous females are infertile; homozygous males are fertile. Please note that the donating investigator reports that the number of homozygotes resulting from a cross between heterozygotes is significantly lower than what the expected Mendelian ratio would predict. Expected coat color from breeding:Black, Agouti
Mating System	+/+ sibling x Heterozygote         (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.